ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.07384917
2	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.49825943
3	DNA deamination (GO:0045006)	5.34497034
4	regulation of regulatory T cell differentiation (GO:0045589)	5.31538330
5	cellular response to ATP (GO:0071318)	4.76713816
6	fucose catabolic process (GO:0019317)	4.42421876
7	L-fucose metabolic process (GO:0042354)	4.42421876
8	L-fucose catabolic process (GO:0042355)	4.42421876
9	positive regulation of interleukin-17 production (GO:0032740)	4.24614320
10	negative regulation of B cell apoptotic process (GO:0002903)	4.07819354
11	positive regulation of isotype switching (GO:0045830)	4.03337013
12	regulation of immunoglobulin secretion (GO:0051023)	4.00228192
13	positive regulation of DNA recombination (GO:0045911)	3.99989829
14	regulation of isotype switching to IgG isotypes (GO:0048302)	3.99953815
15	purine-containing compound salvage (GO:0043101)	3.95988771
16	maturation of 5.8S rRNA (GO:0000460)	3.89915329
17	negative regulation of telomere maintenance (GO:0032205)	3.84973366
18	maturation of SSU-rRNA (GO:0030490)	3.79834100
19	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.65947716
20	positive regulation of defense response to virus by host (GO:0002230)	3.63364522
21	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.63318439
22	GMP metabolic process (GO:0046037)	3.51801887
23	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.51740391
24	glycerophospholipid catabolic process (GO:0046475)	3.49665979
25	rRNA modification (GO:0000154)	3.45363707
26	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.30615544
27	ribosomal small subunit assembly (GO:0000028)	3.28101656
28	water-soluble vitamin biosynthetic process (GO:0042364)	3.27555762
29	behavioral response to nicotine (GO:0035095)	3.25081381
30	cytidine metabolic process (GO:0046087)	3.22380357
31	cytidine catabolic process (GO:0006216)	3.22380357
32	cytidine deamination (GO:0009972)	3.22380357
33	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.20623923
34	parturition (GO:0007567)	3.20332834
35	rRNA catabolic process (GO:0016075)	3.19227573
36	rRNA processing (GO:0006364)	3.17464674
37	mannosylation (GO:0097502)	3.13780311
38	protein K63-linked deubiquitination (GO:0070536)	3.13166807
39	proteasome assembly (GO:0043248)	3.10499814
40	rRNA metabolic process (GO:0016072)	3.10272975
41	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.08954537
42	positive regulation of B cell mediated immunity (GO:0002714)	3.07314140
43	positive regulation of immunoglobulin mediated immune response (GO:0002891)	3.07314140
44	positive regulation of immunoglobulin production (GO:0002639)	3.05994585
45	ATP synthesis coupled proton transport (GO:0015986)	3.02956126
46	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.02956126
47	rRNA methylation (GO:0031167)	3.02918481
48	folic acid-containing compound biosynthetic process (GO:0009396)	3.00538626
49	positive regulation of prostaglandin secretion (GO:0032308)	2.98312697
50	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.97872398
51	GDP-mannose metabolic process (GO:0019673)	2.90989730
52	purine nucleotide salvage (GO:0032261)	2.90692883
53	fucosylation (GO:0036065)	2.90437623
54	regulation of B cell apoptotic process (GO:0002902)	2.89696639
55	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.88370737
56	positive regulation of fatty acid transport (GO:2000193)	2.87252644
57	piRNA metabolic process (GO:0034587)	2.85889223
58	negative regulation of heart rate (GO:0010459)	2.85338958
59	signal peptide processing (GO:0006465)	2.84766127
60	regulation of defense response to virus by host (GO:0050691)	2.83361261
61	activated T cell proliferation (GO:0050798)	2.82727295
62	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.81909061
63	IMP biosynthetic process (GO:0006188)	2.79779979
64	platelet dense granule organization (GO:0060155)	2.79089422
65	cellular response to exogenous dsRNA (GO:0071360)	2.77649768
66	urate metabolic process (GO:0046415)	2.70788619
67	pteridine-containing compound biosynthetic process (GO:0042559)	2.69813143
68	valine metabolic process (GO:0006573)	2.67351219
69	serotonin receptor signaling pathway (GO:0007210)	2.67059481
70	interferon-gamma production (GO:0032609)	2.65818639
71	ribosome biogenesis (GO:0042254)	2.63910708
72	positive regulation of T-helper 1 type immune response (GO:0002827)	2.63767235
73	positive regulation of activated T cell proliferation (GO:0042104)	2.61871606
74	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.61854672
75	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.59948477
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.58165632
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.58165632
78	histone mRNA metabolic process (GO:0008334)	2.57804351
79	resolution of meiotic recombination intermediates (GO:0000712)	2.57376470
80	tRNA processing (GO:0008033)	2.56462438
81	protein neddylation (GO:0045116)	2.50797755
82	GTP biosynthetic process (GO:0006183)	2.50766482
83	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.50363120
84	ncRNA processing (GO:0034470)	2.46956443
85	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.44700469
86	endothelium development (GO:0003158)	2.44495159
87	protein complex biogenesis (GO:0070271)	2.44324264
88	axoneme assembly (GO:0035082)	2.42221079
89	purine nucleobase biosynthetic process (GO:0009113)	2.42165540
90	iron-sulfur cluster assembly (GO:0016226)	2.42020843
91	metallo-sulfur cluster assembly (GO:0031163)	2.42020843
92	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.41217736
93	detection of light stimulus involved in visual perception (GO:0050908)	2.40790108
94	detection of light stimulus involved in sensory perception (GO:0050962)	2.40790108
95	regulation of prostaglandin secretion (GO:0032306)	2.38086054
96	regulation of memory T cell differentiation (GO:0043380)	2.37711664
97	nucleobase biosynthetic process (GO:0046112)	2.36331566
98	isoprenoid biosynthetic process (GO:0008299)	2.36204713
99	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.36016914
100	preassembly of GPI anchor in ER membrane (GO:0016254)	2.35575956

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.55607872
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.94845433
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.51481371
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45010566
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.68840702
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.68339474
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68184273
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61176260
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.55371600
10	VDR_22108803_ChIP-Seq_LS180_Human	2.50918519
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.41727058
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.41355123
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.34509635
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.32911407
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.32634189
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.30484695
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.29387485
18	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.27240587
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.25725528
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20868087
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.13781337
22	EWS_26573619_Chip-Seq_HEK293_Human	2.13388947
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.09368406
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.97194617
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.96847968
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.94037146
27	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.91076065
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85280410
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.83006655
30	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.82751062
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.79991609
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.72172213
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.67115700
34	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.62906585
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.57727287
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57641409
37	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.56336953
38	GATA3_26560356_Chip-Seq_TH2_Human	1.55682611
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.53306531
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.44266966
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42474999
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.41556688
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39809471
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39809471
45	AR_20517297_ChIP-Seq_VCAP_Human	1.36842166
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33114055
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30345252
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.28982707
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.26883955
50	ER_23166858_ChIP-Seq_MCF-7_Human	1.26705992
51	NCOR_22424771_ChIP-Seq_293T_Human	1.25988159
52	TAF15_26573619_Chip-Seq_HEK293_Human	1.25167825
53	P300_19829295_ChIP-Seq_ESCs_Human	1.23435297
54	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.22873069
55	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21930747
56	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21314111
57	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19294014
58	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.18974524
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16754073
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16754073
61	CBP_20019798_ChIP-Seq_JUKART_Human	1.12083977
62	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12083977
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11949790
64	IGF1R_20145208_ChIP-Seq_DFB_Human	1.10081043
65	ERA_21632823_ChIP-Seq_H3396_Human	1.09474005
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09155788
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.09108815
68	DCP1A_22483619_ChIP-Seq_HELA_Human	1.08837944
69	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.07143596
70	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.04469671
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03691260
72	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02525932
73	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00801645
74	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.00297091
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99757238
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99618033
77	GABP_19822575_ChIP-Seq_HepG2_Human	0.98584422
78	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98460422
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.98342201
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.97109902
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96811252
82	TCF4_22108803_ChIP-Seq_LS180_Human	0.96401907
83	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93507694
84	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93289664
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92102703
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91963713
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91861853
88	MYB_26560356_Chip-Seq_TH2_Human	0.91268245
89	GATA3_26560356_Chip-Seq_TH1_Human	0.91071427
90	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.90826808
91	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.90510882
92	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.88821767
93	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.88747367
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.86836146
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.86652430
96	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.86443760
97	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.86084163
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.86070534
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.85054096
100	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.84756289

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.66951308
2	MP0004885_abnormal_endolymph	3.48488446
3	MP0003300_gastrointestinal_ulcer	3.24588554
4	MP0004147_increased_porphyrin_level	3.13040158
5	MP0003195_calcinosis	2.90914297
6	MP0001790_abnormal_immune_system	2.65780921
7	MP0005387_immune_system_phenotype	2.65780921
8	MP0002138_abnormal_hepatobiliary_system	2.64548318
9	MP0000372_irregular_coat_pigmentation	2.55788111
10	MP0008877_abnormal_DNA_methylation	2.51584385
11	MP0001835_abnormal_antigen_presentation	2.48085223
12	MP0008058_abnormal_DNA_repair	2.43495810
13	MP0003763_abnormal_thymus_physiology	2.32247906
14	MP0008057_abnormal_DNA_replication	2.30819659
15	MP0003567_abnormal_fetal_cardiomyocyte	1.97988398
16	MP0000685_abnormal_immune_system	1.96190799
17	MP0003693_abnormal_embryo_hatching	1.93855885
18	MP0002102_abnormal_ear_morphology	1.91075425
19	MP0002938_white_spotting	1.82061432
20	MP0002148_abnormal_hypersensitivity_rea	1.80296177
21	MP0003724_increased_susceptibility_to	1.79305057
22	MP0002876_abnormal_thyroid_physiology	1.76804124
23	MP0008875_abnormal_xenobiotic_pharmacok	1.75137582
24	MP0001853_heart_inflammation	1.73510774
25	MP0003283_abnormal_digestive_organ	1.73280163
26	MP0005075_abnormal_melanosome_morpholog	1.65966935
27	MP0005377_hearing/vestibular/ear_phenot	1.59094229
28	MP0003878_abnormal_ear_physiology	1.59094229
29	MP0005408_hypopigmentation	1.54064280
30	MP0003866_abnormal_defecation	1.53679723
31	MP0005551_abnormal_eye_electrophysiolog	1.53580878
32	MP0006072_abnormal_retinal_apoptosis	1.53442465
33	MP0000465_gastrointestinal_hemorrhage	1.50994107
34	MP0001873_stomach_inflammation	1.44879018
35	MP0005365_abnormal_bile_salt	1.40372061
36	MP0008872_abnormal_physiological_respon	1.39666875
37	MP0004145_abnormal_muscle_electrophysio	1.38974292
38	MP0005167_abnormal_blood-brain_barrier	1.37367467
39	MP0008775_abnormal_heart_ventricle	1.37333575
40	MP0005084_abnormal_gallbladder_morpholo	1.33177519
41	MP0003786_premature_aging	1.31925190
42	MP0005389_reproductive_system_phenotype	1.26500272
43	MP0004142_abnormal_muscle_tone	1.24821743
44	MP0001800_abnormal_humoral_immune	1.24632156
45	MP0005646_abnormal_pituitary_gland	1.24209647
46	MP0004381_abnormal_hair_follicle	1.23903333
47	MP0002693_abnormal_pancreas_physiology	1.19886514
48	MP0003646_muscle_fatigue	1.19785798
49	MP0002837_dystrophic_cardiac_calcinosis	1.15327017
50	MP0009785_altered_susceptibility_to	1.14114294
51	MP0002420_abnormal_adaptive_immunity	1.13530846
52	MP0002090_abnormal_vision	1.12571559
53	MP0001819_abnormal_immune_cell	1.11417945
54	MP0002736_abnormal_nociception_after	1.11339889
55	MP0006035_abnormal_mitochondrial_morpho	1.10824128
56	MP0010094_abnormal_chromosome_stability	1.09514754
57	MP0003806_abnormal_nucleotide_metabolis	1.09386527
58	MP0002160_abnormal_reproductive_system	1.08641093
59	MP0000613_abnormal_salivary_gland	1.07531881
60	MP0002006_tumorigenesis	1.05206555
61	MP0005220_abnormal_exocrine_pancreas	1.03877342
62	MP0006036_abnormal_mitochondrial_physio	1.02636483
63	MP0001919_abnormal_reproductive_system	1.02471365
64	MP0000358_abnormal_cell_content/	1.02231562
65	MP0003045_fibrosis	1.01448604
66	MP0002723_abnormal_immune_serum	1.01169388
67	MP0000604_amyloidosis	1.00792203
68	MP0005000_abnormal_immune_tolerance	1.00383228
69	MP0005645_abnormal_hypothalamus_physiol	0.96628346
70	MP0005332_abnormal_amino_acid	0.96558861
71	MP0002166_altered_tumor_susceptibility	0.96343940
72	MP0010155_abnormal_intestine_physiology	0.95639323
73	MP0006292_abnormal_olfactory_placode	0.93471883
74	MP0003718_maternal_effect	0.93283206
75	MP0002405_respiratory_system_inflammati	0.90596549
76	MP0001845_abnormal_inflammatory_respons	0.90265851
77	MP0005647_abnormal_sex_gland	0.90256558
78	MP0004742_abnormal_vestibular_system	0.89746759
79	MP0002452_abnormal_antigen_presenting	0.89689648
80	MP0002095_abnormal_skin_pigmentation	0.86908323
81	MP0002163_abnormal_gland_morphology	0.85694761
82	MP0005025_abnormal_response_to	0.83532994
83	MP0002254_reproductive_system_inflammat	0.82661869
84	MP0001661_extended_life_span	0.81615715
85	MP0003638_abnormal_response/metabolism_	0.79993265
86	MP0002210_abnormal_sex_determination	0.79234325
87	MP0001663_abnormal_digestive_system	0.78576153
88	MP0002272_abnormal_nervous_system	0.77031368
89	MP0006276_abnormal_autonomic_nervous	0.76422091
90	MP0000689_abnormal_spleen_morphology	0.74866693
91	MP0001968_abnormal_touch/_nociception	0.71231056
92	MP0000427_abnormal_hair_cycle	0.70351077
93	MP0001929_abnormal_gametogenesis	0.69564161
94	MP0009333_abnormal_splenocyte_physiolog	0.67178748
95	MP0002277_abnormal_respiratory_mucosa	0.67140497
96	MP0005410_abnormal_fertilization	0.66584366
97	MP0001984_abnormal_olfaction	0.65899491
98	MP0005253_abnormal_eye_physiology	0.64944111
99	MP0001905_abnormal_dopamine_level	0.64343520
100	MP0009643_abnormal_urine_homeostasis	0.63727558

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dyschromatopsia (HP:0007641)	5.34885783
2	Visual hallucinations (HP:0002367)	4.35001456
3	Testicular atrophy (HP:0000029)	4.29689293
4	Stomatitis (HP:0010280)	3.83616494
5	Hypoproteinemia (HP:0003075)	3.66175658
6	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.59185594
7	Hypoplasia of the pons (HP:0012110)	3.57427016
8	Abnormality of the pons (HP:0007361)	3.53256525
9	Congenital stationary night blindness (HP:0007642)	3.42169992
10	Abnormality of the renal cortex (HP:0011035)	3.42161692
11	Reduced antithrombin III activity (HP:0001976)	3.29031908
12	Central scotoma (HP:0000603)	3.27699821
13	Prostate neoplasm (HP:0100787)	3.21967724
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15196791
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.99033291
16	Type I transferrin isoform profile (HP:0003642)	2.98313607
17	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.92871297
18	3-Methylglutaconic aciduria (HP:0003535)	2.89574412
19	Type 2 muscle fiber atrophy (HP:0003554)	2.88268090
20	Autoimmune hemolytic anemia (HP:0001890)	2.87737546
21	Pancreatic cysts (HP:0001737)	2.87476174
22	Elevated erythrocyte sedimentation rate (HP:0003565)	2.86050643
23	IgG deficiency (HP:0004315)	2.85033790
24	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.83047037
25	Abnormality of alanine metabolism (HP:0010916)	2.83047037
26	Hyperalaninemia (HP:0003348)	2.83047037
27	Constricted visual fields (HP:0001133)	2.76789324
28	Increased cerebral lipofuscin (HP:0011813)	2.76340701
29	Abolished electroretinogram (ERG) (HP:0000550)	2.73305275
30	Abnormality of the labia minora (HP:0012880)	2.73304787
31	Abnormality of DNA repair (HP:0003254)	2.70481214
32	Acute necrotizing encephalopathy (HP:0006965)	2.69973760
33	Abnormal protein glycosylation (HP:0012346)	2.67889723
34	Abnormal glycosylation (HP:0012345)	2.67889723
35	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.67889723
36	Abnormal protein N-linked glycosylation (HP:0012347)	2.67889723
37	Increased CSF lactate (HP:0002490)	2.66650150
38	Increased hepatocellular lipid droplets (HP:0006565)	2.66550208
39	Methylmalonic acidemia (HP:0002912)	2.62971127
40	Abnormality of midbrain morphology (HP:0002418)	2.57040892
41	Molar tooth sign on MRI (HP:0002419)	2.57040892
42	Asplenia (HP:0001746)	2.55222233
43	Acute encephalopathy (HP:0006846)	2.52921963
44	Mitochondrial inheritance (HP:0001427)	2.49865717
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.48870029
46	Hypoglycemic coma (HP:0001325)	2.38848214
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.37804892
48	Lipid accumulation in hepatocytes (HP:0006561)	2.37115006
49	Abnormality of the renal medulla (HP:0100957)	2.35695994
50	Autoimmune thrombocytopenia (HP:0001973)	2.34214313
51	Hypomagnesemia (HP:0002917)	2.33110421
52	Progressive macrocephaly (HP:0004481)	2.31997329
53	Muscle fiber atrophy (HP:0100295)	2.24734110
54	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.24647880
55	Polyuria (HP:0000103)	2.21548884
56	Optic disc pallor (HP:0000543)	2.20978185
57	Meckel diverticulum (HP:0002245)	2.17196022
58	Abnormality of T cell physiology (HP:0011840)	2.16883075
59	Methylmalonic aciduria (HP:0012120)	2.16575012
60	Increased serum lactate (HP:0002151)	2.14318910
61	Clubbing of toes (HP:0100760)	2.12881337
62	Abnormality of the ileum (HP:0001549)	2.11820315
63	Renal cortical cysts (HP:0000803)	2.09873949
64	Hyperinsulinemic hypoglycemia (HP:0000825)	2.08606814
65	Hepatic necrosis (HP:0002605)	2.06551456
66	Tubular atrophy (HP:0000092)	2.03864999
67	Attenuation of retinal blood vessels (HP:0007843)	2.02075942
68	Nephronophthisis (HP:0000090)	2.01070682
69	Gout (HP:0001997)	2.00974428
70	Absent thumb (HP:0009777)	1.99578747
71	Metabolic alkalosis (HP:0200114)	1.99550275
72	Hypokalemic alkalosis (HP:0001949)	1.98773226
73	Hyperaldosteronism (HP:0000859)	1.98728209
74	Pancytopenia (HP:0001876)	1.97860532
75	Abnormality of the preputium (HP:0100587)	1.97082431
76	Renal Fanconi syndrome (HP:0001994)	1.97006056
77	Hypoglycemic seizures (HP:0002173)	1.95733523
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.94465031
79	Abnormality of T cells (HP:0002843)	1.94012209
80	Scotoma (HP:0000575)	1.91967648
81	Abnormality of magnesium homeostasis (HP:0004921)	1.91246671
82	Megaloblastic anemia (HP:0001889)	1.88841491
83	Pancreatic fibrosis (HP:0100732)	1.88535351
84	Cerebral edema (HP:0002181)	1.87695666
85	Abnormal biliary tract physiology (HP:0012439)	1.87314487
86	Bile duct proliferation (HP:0001408)	1.87314487
87	Exertional dyspnea (HP:0002875)	1.85527995
88	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.84963415
89	Tubulointerstitial fibrosis (HP:0005576)	1.84675488
90	Polydipsia (HP:0001959)	1.84301612
91	Abnormal drinking behavior (HP:0030082)	1.84301612
92	Abnormality of the prostate (HP:0008775)	1.83326481
93	Abnormal urine output (HP:0012590)	1.83230685
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80662285
95	Azoospermia (HP:0000027)	1.77996640
96	Increased intramyocellular lipid droplets (HP:0012240)	1.77427789
97	Decreased circulating renin level (HP:0003351)	1.76824367
98	Decreased central vision (HP:0007663)	1.76721707
99	Glycosuria (HP:0003076)	1.76553474
100	Abnormality of urine glucose concentration (HP:0011016)	1.76553474

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	5.09519914
2	TXK	3.74357879
3	ZAK	3.51177045
4	MAP4K2	3.18267204
5	GRK1	2.83413299
6	VRK2	2.74793058
7	FRK	2.73174863
8	ADRBK2	2.54891638
9	NUAK1	2.26342540
10	MAP4K1	2.08639050
11	MST4	2.05822472
12	BMPR1B	2.02267353
13	MUSK	2.00148857
14	FES	1.91794620
15	TEC	1.82318492
16	MAP3K12	1.77715549
17	TAF1	1.76927470
18	NEK1	1.67039013
19	TAOK3	1.65432729
20	EIF2AK3	1.55172773
21	ACVR1B	1.52278168
22	WNK3	1.51013778
23	IKBKB	1.49350348
24	TLK1	1.45742479
25	PASK	1.39580299
26	TSSK6	1.36507644
27	MAPKAPK3	1.31457483
28	NME2	1.21761879
29	CDK8	1.21204868
30	CSK	1.19882767
31	BCKDK	1.17978240
32	BUB1	1.15336480
33	DAPK1	1.15181058
34	VRK1	1.15022051
35	NLK	1.14077514
36	TGFBR1	1.10851925
37	MAPKAPK5	1.06098360
38	MKNK1	1.03688673
39	DAPK2	1.03180283
40	PINK1	1.02039264
41	JAK3	1.01274345
42	BTK	0.99487807
43	PLK3	0.99401333
44	PLK4	0.92956523
45	PHKG2	0.90847322
46	PHKG1	0.90847322
47	SYK	0.88929404
48	MYLK	0.84046364
49	OXSR1	0.83522171
50	INSRR	0.83271899
51	MATK	0.81847207
52	CAMK2D	0.80595444
53	MAP3K11	0.79387397
54	ITK	0.79346990
55	KIT	0.75191291
56	DYRK2	0.68050724
57	CSNK1A1L	0.66313068
58	PRKCQ	0.66261955
59	ADRBK1	0.65931762
60	LYN	0.65478931
61	TGFBR2	0.65133284
62	GRK5	0.65066105
63	CHEK2	0.62361356
64	FER	0.62104527
65	BMPR2	0.61224329
66	GRK7	0.56424815
67	CSNK1G1	0.56153634
68	KDR	0.54233175
69	LMTK2	0.52993105
70	CSNK1G3	0.51849629
71	MAP2K6	0.51798954
72	IKBKE	0.51608477
73	CSNK1A1	0.49797524
74	PRKCE	0.49242180
75	LCK	0.47131067
76	EIF2AK2	0.45594690
77	CSNK1G2	0.43512394
78	RPS6KA5	0.43067707
79	IGF1R	0.42948463
80	ALK	0.42111573
81	ATR	0.42063951
82	NEK9	0.41078371
83	PLK1	0.41028919
84	STK39	0.39591172
85	PDK2	0.38904377
86	ATM	0.35790948
87	PTK2B	0.35627360
88	CSNK2A1	0.34647301
89	NME1	0.33895961
90	PAK4	0.33763795
91	IRAK4	0.33340717
92	CSNK2A2	0.32251672
93	CDC7	0.31569812
94	MOS	0.31378006
95	MAP3K13	0.31357083
96	RPS6KB1	0.30738388
97	FLT3	0.30678478
98	PRKACA	0.30344121
99	PLK2	0.30238146
100	WNK4	0.30083926

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.14888766
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.64203946
3	Type I diabetes mellitus_Homo sapiens_hsa04940	2.41395082
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.34214047
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32904309
6	One carbon pool by folate_Homo sapiens_hsa00670	2.31003934
7	Allograft rejection_Homo sapiens_hsa05330	2.24652454
8	Ribosome_Homo sapiens_hsa03010	2.15417370
9	Basal transcription factors_Homo sapiens_hsa03022	2.15355615
10	Homologous recombination_Homo sapiens_hsa03440	2.06655487
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.02625988
12	Protein export_Homo sapiens_hsa03060	2.01830910
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.98474324
14	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.96922373
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.96377426
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.88399099
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80096127
18	Asthma_Homo sapiens_hsa05310	1.79541897
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.74527593
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.72052430
21	Mismatch repair_Homo sapiens_hsa03430	1.71340785
22	RNA degradation_Homo sapiens_hsa03018	1.69782203
23	RNA polymerase_Homo sapiens_hsa03020	1.68821309
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.62054662
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.58238826
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58150539
27	Phototransduction_Homo sapiens_hsa04744	1.53542442
28	Parkinsons disease_Homo sapiens_hsa05012	1.51303519
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.43821049
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.37875270
31	Sulfur metabolism_Homo sapiens_hsa00920	1.36692844
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.35294335
33	RNA transport_Homo sapiens_hsa03013	1.32158681
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.31655000
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.28681237
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.28270059
37	Regulation of autophagy_Homo sapiens_hsa04140	1.25333849
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.22884811
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.18947670
40	Propanoate metabolism_Homo sapiens_hsa00640	1.17986726
41	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.17721244
42	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.16461709
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.15862452
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.15691696
45	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.12266604
46	Purine metabolism_Homo sapiens_hsa00230	1.12029680
47	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.10906962
48	Antigen processing and presentation_Homo sapiens_hsa04612	1.10431545
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.08999957
50	Butanoate metabolism_Homo sapiens_hsa00650	1.08947283
51	Base excision repair_Homo sapiens_hsa03410	1.04367450
52	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.00936835
53	Huntingtons disease_Homo sapiens_hsa05016	0.98115709
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96793667
55	Spliceosome_Homo sapiens_hsa03040	0.96006368
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95869064
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.93898881
58	DNA replication_Homo sapiens_hsa03030	0.92415490
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91226782
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.87073496
61	Fatty acid elongation_Homo sapiens_hsa00062	0.84650969
62	Alzheimers disease_Homo sapiens_hsa05010	0.83481060
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.82865768
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82070067
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79496034
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79106059
67	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76449380
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.75688276
69	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73564424
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73155052
71	ABC transporters_Homo sapiens_hsa02010	0.72688129
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71451851
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.70648880
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69177208
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69132384
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66371756
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.65034594
78	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.64984286
79	Caffeine metabolism_Homo sapiens_hsa00232	0.64074421
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63289131
81	Metabolic pathways_Homo sapiens_hsa01100	0.60512836
82	Fatty acid degradation_Homo sapiens_hsa00071	0.60172152
83	Histidine metabolism_Homo sapiens_hsa00340	0.56993554
84	Retinol metabolism_Homo sapiens_hsa00830	0.56920345
85	Folate biosynthesis_Homo sapiens_hsa00790	0.55686808
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55107201
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.51727230
88	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48629805
89	Glutathione metabolism_Homo sapiens_hsa00480	0.47872789
90	Peroxisome_Homo sapiens_hsa04146	0.47776653
91	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46338416
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41808653
93	Sulfur relay system_Homo sapiens_hsa04122	0.40015298
94	Mineral absorption_Homo sapiens_hsa04978	0.39370920
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37040469
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35404359
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35396018
98	Nicotine addiction_Homo sapiens_hsa05033	0.34483299
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34002055
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.33815912

EEF1A1P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »