ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.76586703
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.71534214
3	cytidine deamination (GO:0009972)	5.61911806
4	cytidine metabolic process (GO:0046087)	5.61911806
5	cytidine catabolic process (GO:0006216)	5.61911806
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.90213816
7	ribosomal small subunit assembly (GO:0000028)	4.68523396
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.08691470
9	ATP synthesis coupled proton transport (GO:0015986)	4.08310938
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.08310938
11	regulation of regulatory T cell differentiation (GO:0045589)	3.79194910
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.60343955
13	platelet dense granule organization (GO:0060155)	3.47507099
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.36313271
15	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.29750416
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.28212927
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.28212927
18	cellular response to interleukin-15 (GO:0071350)	3.27813291
19	positive regulation of defense response to virus by host (GO:0002230)	3.21472726
20	protein neddylation (GO:0045116)	3.20774778
21	response to pheromone (GO:0019236)	3.15005036
22	negative T cell selection (GO:0043383)	3.14660288
23	respiratory electron transport chain (GO:0022904)	3.10722345
24	electron transport chain (GO:0022900)	3.10322651
25	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.02174357
26	regulation of cellular amino acid metabolic process (GO:0006521)	3.01818998
27	L-fucose catabolic process (GO:0042355)	3.00666329
28	fucose catabolic process (GO:0019317)	3.00666329
29	L-fucose metabolic process (GO:0042354)	3.00666329
30	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.00024226
31	behavioral response to nicotine (GO:0035095)	2.99088431
32	protein complex biogenesis (GO:0070271)	2.98537107
33	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.98060812
34	regulation of T cell receptor signaling pathway (GO:0050856)	2.94583355
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.93794487
36	proteasome assembly (GO:0043248)	2.93722555
37	regulation of chronic inflammatory response (GO:0002676)	2.93126037
38	regulation of B cell receptor signaling pathway (GO:0050855)	2.92864910
39	viral transcription (GO:0019083)	2.91358776
40	positive thymic T cell selection (GO:0045059)	2.90792480
41	positive T cell selection (GO:0043368)	2.89537965
42	negative regulation of T cell apoptotic process (GO:0070233)	2.89369340
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.86869683
44	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.85123386
45	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.83990058
46	translational termination (GO:0006415)	2.83580583
47	regulation of T cell mediated cytotoxicity (GO:0001914)	2.81655316
48	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.80028598
49	positive regulation of prostaglandin secretion (GO:0032308)	2.79634443
50	sequestering of actin monomers (GO:0042989)	2.78866835
51	mannosylation (GO:0097502)	2.78786923
52	cotranslational protein targeting to membrane (GO:0006613)	2.78538580
53	protein targeting to ER (GO:0045047)	2.78334188
54	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.77593271
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.77217821
56	translational elongation (GO:0006414)	2.76667392
57	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.76221292
58	GPI anchor metabolic process (GO:0006505)	2.75969474
59	regulation of isotype switching to IgG isotypes (GO:0048302)	2.75900173
60	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.75764028
61	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.74794833
62	respiratory chain complex IV assembly (GO:0008535)	2.74131405
63	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.73697650
64	response to interferon-beta (GO:0035456)	2.73273544
65	positive regulation of calcium-mediated signaling (GO:0050850)	2.71980193
66	negative regulation of mast cell activation (GO:0033004)	2.71242663
67	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.71057235
68	negative regulation by host of viral transcription (GO:0043922)	2.70031637
69	protein localization to endoplasmic reticulum (GO:0070972)	2.69973047
70	actin nucleation (GO:0045010)	2.69018830
71	GPI anchor biosynthetic process (GO:0006506)	2.67667703
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.65875936
73	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65246884
74	NADH dehydrogenase complex assembly (GO:0010257)	2.65246884
75	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65246884
76	positive regulation of interleukin-8 secretion (GO:2000484)	2.64939053
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.64916252
78	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.64916252
79	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.64916252
80	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.64294757
81	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.64191128
82	positive regulation of cell killing (GO:0031343)	2.63377435
83	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.62942697
84	regulation of alpha-beta T cell proliferation (GO:0046640)	2.62125859
85	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.62064791
86	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.62064791
87	regulation of interleukin-8 secretion (GO:2000482)	2.61599030
88	negative thymic T cell selection (GO:0045060)	2.61185380
89	regulation of activation of Janus kinase activity (GO:0010533)	2.60935794
90	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.59357422
91	maturation of SSU-rRNA (GO:0030490)	2.58961020
92	DNA demethylation (GO:0080111)	2.58571780
93	cytochrome complex assembly (GO:0017004)	2.56905620
94	metallo-sulfur cluster assembly (GO:0031163)	2.56772987
95	iron-sulfur cluster assembly (GO:0016226)	2.56772987
96	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.56721737
97	termination of RNA polymerase III transcription (GO:0006386)	2.56721737
98	pyrimidine nucleoside catabolic process (GO:0046135)	2.54671786
99	regulation of cell killing (GO:0031341)	2.51494876
100	preassembly of GPI anchor in ER membrane (GO:0016254)	2.51156320

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.59142276
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.52572486
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.22536361
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.00584444
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.99824663
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.95447448
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.88152082
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.82762550
9	VDR_22108803_ChIP-Seq_LS180_Human	2.79755800
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.72320622
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60532954
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58998071
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.47818195
14	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.44301407
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.39638611
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.37344417
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37201889
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.36269240
19	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.20301198
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.13293599
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.13221857
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.96463420
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.95340088
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.91590651
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.90525319
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79799311
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78009625
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.67372102
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.65517837
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63616254
31	MYB_26560356_Chip-Seq_TH2_Human	1.61861610
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.58715747
33	GATA3_26560356_Chip-Seq_TH2_Human	1.56320640
34	EWS_26573619_Chip-Seq_HEK293_Human	1.56184156
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.52604685
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50323909
37	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50323909
38	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49513157
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.47937026
40	AR_20517297_ChIP-Seq_VCAP_Human	1.45538529
41	FUS_26573619_Chip-Seq_HEK293_Human	1.43522329
42	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38710686
43	RUNX_20019798_ChIP-Seq_JUKART_Human	1.36274894
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36101432
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34772261
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34772261
47	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.34065407
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32134650
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31446685
50	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.31075284
51	P300_19829295_ChIP-Seq_ESCs_Human	1.28709767
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.27267021
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24012090
54	GATA3_27048872_Chip-Seq_THYMUS_Human	1.23049906
55	NCOR_22424771_ChIP-Seq_293T_Human	1.22635435
56	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.22469394
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.22388411
58	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21591994
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21503543
60	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.20994802
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19744380
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19373844
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19086163
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18790981
65	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17115082
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17105282
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.15702824
68	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15702824
69	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.15427119
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15039091
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14882581
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14228059
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11258721
74	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.10579107
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09670894
76	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09410540
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08830527
78	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.05388834
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05160795
80	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04258303
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.03593545
82	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02932389
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02852547
84	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.01492977
85	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01226451
86	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.01105989
87	ERG_20517297_ChIP-Seq_VCAP_Human	1.01046576
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00805811
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.99623645
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99512356
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.98887152
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98495817
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98253893
94	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.95761929
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93477292
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93454506
97	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93280948
98	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92636294
99	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92147710
100	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91516187

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.66087443
2	MP0001835_abnormal_antigen_presentation	3.14028933
3	MP0009785_altered_susceptibility_to	2.67354364
4	MP0006072_abnormal_retinal_apoptosis	2.42122368
5	MP0005075_abnormal_melanosome_morpholog	2.35174352
6	MP0002102_abnormal_ear_morphology	2.32193760
7	MP0001873_stomach_inflammation	2.23131933
8	MP0003763_abnormal_thymus_physiology	2.15812406
9	MP0001800_abnormal_humoral_immune	2.04575233
10	MP0002148_abnormal_hypersensitivity_rea	2.04541821
11	MP0002166_altered_tumor_susceptibility	2.04065044
12	MP0005000_abnormal_immune_tolerance	1.96660950
13	MP0005645_abnormal_hypothalamus_physiol	1.95004988
14	MP0002876_abnormal_thyroid_physiology	1.92314323
15	MP0006292_abnormal_olfactory_placode	1.91308889
16	MP0009333_abnormal_splenocyte_physiolog	1.89346293
17	MP0000372_irregular_coat_pigmentation	1.89195789
18	MP0004147_increased_porphyrin_level	1.86188300
19	MP0008872_abnormal_physiological_respon	1.82183956
20	MP0006082_CNS_inflammation	1.78628630
21	MP0008877_abnormal_DNA_methylation	1.78115458
22	MP0000685_abnormal_immune_system	1.75563270
23	MP0003866_abnormal_defecation	1.75150421
24	MP0009379_abnormal_foot_pigmentation	1.74650170
25	MP0002723_abnormal_immune_serum	1.73823287
26	MP0002006_tumorigenesis	1.72921950
27	MP0003011_delayed_dark_adaptation	1.71786992
28	MP0008875_abnormal_xenobiotic_pharmacok	1.68591186
29	MP0001790_abnormal_immune_system	1.66721682
30	MP0005387_immune_system_phenotype	1.66721682
31	MP0003195_calcinosis	1.65629430
32	MP0002420_abnormal_adaptive_immunity	1.64640133
33	MP0005551_abnormal_eye_electrophysiolog	1.64548779
34	MP0001819_abnormal_immune_cell	1.61658882
35	MP0005084_abnormal_gallbladder_morpholo	1.54306584
36	MP0002837_dystrophic_cardiac_calcinosis	1.52135702
37	MP0002138_abnormal_hepatobiliary_system	1.51351542
38	MP0005025_abnormal_response_to	1.50775158
39	MP0003646_muscle_fatigue	1.50704267
40	MP0005253_abnormal_eye_physiology	1.50032359
41	MP0002452_abnormal_antigen_presenting	1.46812205
42	MP0002163_abnormal_gland_morphology	1.45123719
43	MP0001968_abnormal_touch/_nociception	1.44753663
44	MP0010155_abnormal_intestine_physiology	1.43418884
45	MP0002736_abnormal_nociception_after	1.40400129
46	MP0002277_abnormal_respiratory_mucosa	1.37038755
47	MP0003806_abnormal_nucleotide_metabolis	1.31543318
48	MP0001986_abnormal_taste_sensitivity	1.30139542
49	MP0003724_increased_susceptibility_to	1.28076075
50	MP0002933_joint_inflammation	1.26651515
51	MP0001845_abnormal_inflammatory_respons	1.20053206
52	MP0002398_abnormal_bone_marrow	1.19879882
53	MP0000716_abnormal_immune_system	1.19795725
54	MP0005646_abnormal_pituitary_gland	1.19552019
55	MP0005379_endocrine/exocrine_gland_phen	1.18701831
56	MP0008995_early_reproductive_senescence	1.17549860
57	MP0010386_abnormal_urinary_bladder	1.16676467
58	MP0001919_abnormal_reproductive_system	1.16434471
59	MP0003786_premature_aging	1.16337825
60	MP0000689_abnormal_spleen_morphology	1.13980984
61	MP0003283_abnormal_digestive_organ	1.12205032
62	MP0001905_abnormal_dopamine_level	1.11675251
63	MP0009764_decreased_sensitivity_to	1.08462924
64	MP0005360_urolithiasis	1.08445738
65	MP0005389_reproductive_system_phenotype	1.08210211
66	MP0002095_abnormal_skin_pigmentation	1.07853780
67	MP0004142_abnormal_muscle_tone	1.04638777
68	MP0002405_respiratory_system_inflammati	1.04371901
69	MP0004885_abnormal_endolymph	1.03301181
70	MP0003878_abnormal_ear_physiology	1.02060131
71	MP0005377_hearing/vestibular/ear_phenot	1.02060131
72	MP0002234_abnormal_pharynx_morphology	1.00345110
73	MP0002722_abnormal_immune_system	0.98304090
74	MP0004145_abnormal_muscle_electrophysio	0.96793530
75	MP0002693_abnormal_pancreas_physiology	0.95441295
76	MP0000703_abnormal_thymus_morphology	0.94353558
77	MP0002638_abnormal_pupillary_reflex	0.93151597
78	MP0008058_abnormal_DNA_repair	0.92874781
79	MP0008469_abnormal_protein_level	0.91399146
80	MP0002429_abnormal_blood_cell	0.90102818
81	MP0001764_abnormal_homeostasis	0.89325072
82	MP0005636_abnormal_mineral_homeostasis	0.88968543
83	MP0003252_abnormal_bile_duct	0.88450775
84	MP0005410_abnormal_fertilization	0.88357297
85	MP0003136_yellow_coat_color	0.87681481
86	MP0001501_abnormal_sleep_pattern	0.86830953
87	MP0005174_abnormal_tail_pigmentation	0.86745874
88	MP0006276_abnormal_autonomic_nervous	0.86569224
89	MP0002419_abnormal_innate_immunity	0.84182486
90	MP0003436_decreased_susceptibility_to	0.83749880
91	MP0005085_abnormal_gallbladder_physiolo	0.83061524
92	MP0002938_white_spotting	0.81776832
93	MP0003880_abnormal_central_pattern	0.77752703
94	MP0005332_abnormal_amino_acid	0.74009323
95	MP0003567_abnormal_fetal_cardiomyocyte	0.73538848
96	MP0000465_gastrointestinal_hemorrhage	0.73439433
97	MP0009745_abnormal_behavioral_response	0.72898452
98	MP0006036_abnormal_mitochondrial_physio	0.72673155
99	MP0002272_abnormal_nervous_system	0.72531195
100	MP0001765_abnormal_ion_homeostasis	0.71029818

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.15110466
2	Aplastic anemia (HP:0001915)	3.73485079
3	Severe combined immunodeficiency (HP:0004430)	3.58942332
4	Mitochondrial inheritance (HP:0001427)	3.53953011
5	Acute necrotizing encephalopathy (HP:0006965)	3.45979102
6	Hypoproteinemia (HP:0003075)	3.41905911
7	Congenital stationary night blindness (HP:0007642)	3.41828045
8	T lymphocytopenia (HP:0005403)	3.32780300
9	Abnormality of T cell number (HP:0011839)	3.31197437
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.22453614
11	Increased hepatocellular lipid droplets (HP:0006565)	3.21677540
12	Increased CSF lactate (HP:0002490)	3.19298516
13	Thyroiditis (HP:0100646)	3.10499553
14	Pancreatic cysts (HP:0001737)	3.10364572
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.07516158
16	3-Methylglutaconic aciduria (HP:0003535)	3.03303136
17	Lipid accumulation in hepatocytes (HP:0006561)	3.03183515
18	Attenuation of retinal blood vessels (HP:0007843)	3.02818924
19	Abnormality of B cell number (HP:0010975)	3.02023885
20	Hepatocellular necrosis (HP:0001404)	3.00501027
21	Progressive macrocephaly (HP:0004481)	2.97461906
22	Stomatitis (HP:0010280)	2.95769134
23	Acute encephalopathy (HP:0006846)	2.94412276
24	Methylmalonic acidemia (HP:0002912)	2.90718466
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.86767081
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81603104
27	Hepatic necrosis (HP:0002605)	2.79406995
28	Abnormality of T cells (HP:0002843)	2.77400578
29	Increased IgM level (HP:0003496)	2.76337650
30	Renal cortical cysts (HP:0000803)	2.75769304
31	B lymphocytopenia (HP:0010976)	2.71356608
32	Renal Fanconi syndrome (HP:0001994)	2.69154601
33	Abolished electroretinogram (ERG) (HP:0000550)	2.69039151
34	Combined immunodeficiency (HP:0005387)	2.67411237
35	Autoimmune hemolytic anemia (HP:0001890)	2.63965379
36	Increased intramyocellular lipid droplets (HP:0012240)	2.63170015
37	Abnormal rod and cone electroretinograms (HP:0008323)	2.59285155
38	Optic disc pallor (HP:0000543)	2.57295109
39	Abnormality of the prostate (HP:0008775)	2.56323609
40	Constricted visual fields (HP:0001133)	2.55498477
41	Abnormality of the renal cortex (HP:0011035)	2.54929742
42	Abnormality of eosinophils (HP:0001879)	2.53088675
43	True hermaphroditism (HP:0010459)	2.47387428
44	Abnormality of midbrain morphology (HP:0002418)	2.46246666
45	Molar tooth sign on MRI (HP:0002419)	2.46246666
46	Pancreatic fibrosis (HP:0100732)	2.45958250
47	Methylmalonic aciduria (HP:0012120)	2.43455237
48	Congenital, generalized hypertrichosis (HP:0004540)	2.39403697
49	Decreased central vision (HP:0007663)	2.39220265
50	Increased serum lactate (HP:0002151)	2.37260849
51	Cerebral edema (HP:0002181)	2.33121168
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.32643668
53	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.27712084
54	Abnormality of macular pigmentation (HP:0008002)	2.21912796
55	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21347655
56	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21347655
57	Increased muscle lipid content (HP:0009058)	2.19577778
58	Lactic acidosis (HP:0003128)	2.16864086
59	Exertional dyspnea (HP:0002875)	2.16627738
60	Nephronophthisis (HP:0000090)	2.15251171
61	Type I transferrin isoform profile (HP:0003642)	2.10204577
62	Abnormality of T cell physiology (HP:0011840)	2.08556136
63	Pancytopenia (HP:0001876)	2.06358839
64	Panhypogammaglobulinemia (HP:0003139)	2.06249442
65	Abnormality of alanine metabolism (HP:0010916)	2.06080802
66	Hyperalaninemia (HP:0003348)	2.06080802
67	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.06080802
68	Eosinophilia (HP:0001880)	2.04862234
69	Lethargy (HP:0001254)	2.02933753
70	Type 2 muscle fiber atrophy (HP:0003554)	2.02383121
71	Abnormal number of erythroid precursors (HP:0012131)	2.00412637
72	Chronic diarrhea (HP:0002028)	1.98885431
73	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96241671
74	IgM deficiency (HP:0002850)	1.94223412
75	Glycosuria (HP:0003076)	1.94176328
76	Abnormality of urine glucose concentration (HP:0011016)	1.94176328
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.93478526
78	Type II lissencephaly (HP:0007260)	1.93173838
79	Asplenia (HP:0001746)	1.92549180
80	Abnormality of vitamin B metabolism (HP:0004340)	1.90360225
81	Abnormality of cells of the erythroid lineage (HP:0012130)	1.89991712
82	Medial flaring of the eyebrow (HP:0010747)	1.89743129
83	Aplasia/hypoplasia of the uterus (HP:0008684)	1.89506468
84	Ketosis (HP:0001946)	1.88314157
85	Stomach cancer (HP:0012126)	1.88282882
86	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.86911718
87	Oral leukoplakia (HP:0002745)	1.86609815
88	Hypoalbuminemia (HP:0003073)	1.86412676
89	Abnormal albumin level (HP:0012116)	1.86412676
90	Abnormal protein glycosylation (HP:0012346)	1.86264452
91	Abnormal glycosylation (HP:0012345)	1.86264452
92	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.86264452
93	Abnormal protein N-linked glycosylation (HP:0012347)	1.86264452
94	Abnormality of the renal medulla (HP:0100957)	1.85891579
95	Abnormality of the pons (HP:0007361)	1.85271734
96	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.84315917
97	Dicarboxylic aciduria (HP:0003215)	1.84315917
98	Keratoconus (HP:0000563)	1.82049862
99	Increased corneal curvature (HP:0100692)	1.82049862
100	Pendular nystagmus (HP:0012043)	1.78919131

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	5.13757711
2	MAP4K2	3.11669506
3	KDR	3.05467895
4	TAOK3	2.90453770
5	TESK2	2.90078593
6	ADRBK2	2.49194347
7	ZAK	2.44534171
8	BCKDK	2.42121991
9	GRK1	2.35998142
10	TLK1	2.34894810
11	NUAK1	2.29638878
12	VRK2	2.29347127
13	FRK	2.17885083
14	MAP4K1	2.05631750
15	CDK19	1.99677800
16	KIT	1.90544264
17	FES	1.85284512
18	MST4	1.71356116
19	PASK	1.63104886
20	ITK	1.59623514
21	TEC	1.59197215
22	MAP3K12	1.58193517
23	VRK1	1.52431321
24	PINK1	1.40042406
25	BMPR1B	1.35083414
26	IKBKB	1.34071601
27	EIF2AK3	1.33885833
28	GRK6	1.32555585
29	STK16	1.31531228
30	SYK	1.28245275
31	WNK4	1.27246742
32	WNK3	1.25832216
33	TIE1	1.20690147
34	INSRR	1.16261290
35	IKBKE	1.08429461
36	OXSR1	1.01631279
37	TRIM28	1.00899867
38	PRKCQ	0.99237439
39	MUSK	0.95598381
40	BMPR2	0.95174347
41	SCYL2	0.93143793
42	LCK	0.92493657
43	BUB1	0.91994546
44	MAPKAPK3	0.85646400
45	DAPK1	0.82234211
46	ACVR1B	0.81768775
47	MAP2K6	0.80059874
48	CAMKK2	0.79935192
49	LIMK1	0.79379312
50	GRK7	0.78343819
51	LYN	0.77464427
52	DAPK2	0.74595447
53	ERBB3	0.74124401
54	BTK	0.74024837
55	CSF1R	0.73886246
56	MYLK	0.69634594
57	STK39	0.65009323
58	ADRBK1	0.62373816
59	CSK	0.61312080
60	RPS6KA5	0.60382490
61	TBK1	0.59848360
62	RPS6KA4	0.59407683
63	DYRK2	0.59028805
64	MAPK13	0.58184422
65	NME1	0.57948717
66	FLT3	0.55116484
67	JAK3	0.53913989
68	CSNK1G1	0.52972145
69	NLK	0.52866108
70	IGF1R	0.51506020
71	SRPK1	0.50397104
72	ZAP70	0.49225829
73	PHKG1	0.48608060
74	PHKG2	0.48608060
75	CSNK1G3	0.46668786
76	PRKCE	0.45795820
77	GRK5	0.45162250
78	TESK1	0.44012858
79	TGFBR1	0.43716474
80	TAF1	0.43428340
81	PIK3CG	0.43406317
82	PIM1	0.41604058
83	OBSCN	0.40608510
84	PRKACA	0.39966758
85	PRKCA	0.39238868
86	MAP3K4	0.38881784
87	PLK3	0.38683683
88	EIF2AK2	0.38490563
89	MATK	0.37436114
90	CSNK1G2	0.35186515
91	DAPK3	0.33571964
92	MAP3K14	0.33108485
93	PIK3CA	0.32632303
94	BCR	0.31825541
95	TRPM7	0.31532404
96	CSNK2A1	0.29579295
97	CSNK1A1	0.27549769
98	HCK	0.27460602
99	MAP3K11	0.25800898
100	CSNK2A2	0.25581475

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.75333356
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.64913465
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.28254366
4	Ribosome_Homo sapiens_hsa03010	3.07104343
5	Allograft rejection_Homo sapiens_hsa05330	2.84626552
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.81641333
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.80359289
8	Asthma_Homo sapiens_hsa05310	2.59927776
9	Parkinsons disease_Homo sapiens_hsa05012	2.59668523
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.45963918
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.34701781
12	Protein export_Homo sapiens_hsa03060	2.32173576
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.25345605
14	RNA polymerase_Homo sapiens_hsa03020	2.03459796
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.98006020
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91461821
17	Phototransduction_Homo sapiens_hsa04744	1.85539291
18	Alzheimers disease_Homo sapiens_hsa05010	1.64052033
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.62057052
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.61636693
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57783950
22	Huntingtons disease_Homo sapiens_hsa05016	1.53963436
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.48535245
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.48231912
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.39219504
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37388298
27	RNA degradation_Homo sapiens_hsa03018	1.29148602
28	Homologous recombination_Homo sapiens_hsa03440	1.25633002
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25116206
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.22217738
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19173303
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18308149
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17226089
34	Propanoate metabolism_Homo sapiens_hsa00640	1.16274906
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.13512738
36	Peroxisome_Homo sapiens_hsa04146	1.12075225
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.10285137
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.05661457
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03591169
40	Caffeine metabolism_Homo sapiens_hsa00232	1.01355521
41	Butanoate metabolism_Homo sapiens_hsa00650	0.98942307
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97847044
43	Sulfur metabolism_Homo sapiens_hsa00920	0.95769126
44	One carbon pool by folate_Homo sapiens_hsa00670	0.92827980
45	Basal transcription factors_Homo sapiens_hsa03022	0.89490630
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89274316
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.84755723
48	Purine metabolism_Homo sapiens_hsa00230	0.84182711
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.84059464
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82039344
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.81445493
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80323756
53	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79956311
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.77825870
55	Viral myocarditis_Homo sapiens_hsa05416	0.77221762
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76495048
57	Fanconi anemia pathway_Homo sapiens_hsa03460	0.76209204
58	Retinol metabolism_Homo sapiens_hsa00830	0.73717812
59	Regulation of autophagy_Homo sapiens_hsa04140	0.72120670
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71871190
61	Olfactory transduction_Homo sapiens_hsa04740	0.71402441
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.70545783
63	Mismatch repair_Homo sapiens_hsa03430	0.70050341
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69688371
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67765753
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65503308
67	Measles_Homo sapiens_hsa05162	0.59621383
68	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58455191
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.57485233
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.57315022
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.57189094
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.55288172
73	Metabolic pathways_Homo sapiens_hsa01100	0.55157285
74	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54256770
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53783452
76	RNA transport_Homo sapiens_hsa03013	0.52405109
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50935542
78	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49708293
79	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.48713836
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.48150525
81	Taste transduction_Homo sapiens_hsa04742	0.47107135
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46164104
83	Spliceosome_Homo sapiens_hsa03040	0.44638381
84	Fatty acid elongation_Homo sapiens_hsa00062	0.43568346
85	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42562030
86	Base excision repair_Homo sapiens_hsa03410	0.40145349
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38901307
88	Herpes simplex infection_Homo sapiens_hsa05168	0.36711226
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.36287180
90	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.35151984
91	Nicotine addiction_Homo sapiens_hsa05033	0.34784235
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33727361
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33062479
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32793212
95	Glutathione metabolism_Homo sapiens_hsa00480	0.29784338
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27356247
97	Non-homologous end-joining_Homo sapiens_hsa03450	0.26956137
98	Leishmaniasis_Homo sapiens_hsa05140	0.26843560
99	Salivary secretion_Homo sapiens_hsa04970	0.23843710
100	DNA replication_Homo sapiens_hsa03030	0.22329879

EEF1A1P22

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »