EEF1A1P24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.77747288
2response to gravity (GO:0009629)5.69543682
3striated muscle atrophy (GO:0014891)4.71878212
4water-soluble vitamin biosynthetic process (GO:0042364)4.66980188
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.61651935
6ATP synthesis coupled proton transport (GO:0015986)4.61651935
7muscle atrophy (GO:0014889)4.47982186
8skeletal muscle adaptation (GO:0043501)4.42830112
9protein K6-linked ubiquitination (GO:0085020)4.13016118
10regulation of skeletal muscle contraction (GO:0014819)4.01279563
11cytidine deamination (GO:0009972)3.96075566
12cytidine metabolic process (GO:0046087)3.96075566
13cytidine catabolic process (GO:0006216)3.96075566
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.90879335
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.90879335
16negative regulation of muscle hypertrophy (GO:0014741)3.89189194
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86446638
18ribosomal small subunit assembly (GO:0000028)3.81456902
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72630928
20exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.66834671
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.52987050
22NADH dehydrogenase complex assembly (GO:0010257)3.52987050
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52987050
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.50652005
25chaperone-mediated protein transport (GO:0072321)3.47317720
26proteasome assembly (GO:0043248)3.46439211
27protein complex biogenesis (GO:0070271)3.40441072
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.38488296
29regulation of cellular amino acid metabolic process (GO:0006521)3.36395782
30GTP biosynthetic process (GO:0006183)3.34089152
31response to muscle activity (GO:0014850)3.32817835
32regulation of immunoglobulin secretion (GO:0051023)3.32317567
33positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.27865349
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.26561829
35rRNA modification (GO:0000154)3.26288242
36mitochondrial respiratory chain complex assembly (GO:0033108)3.22506546
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.21371682
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15668687
39pseudouridine synthesis (GO:0001522)3.14707635
40signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11391002
41signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11391002
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11391002
43rRNA processing (GO:0006364)3.09291358
44signal transduction involved in DNA integrity checkpoint (GO:0072401)3.05808227
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.05808227
46fucose catabolic process (GO:0019317)3.05486653
47L-fucose metabolic process (GO:0042354)3.05486653
48L-fucose catabolic process (GO:0042355)3.05486653
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05356738
50regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.04766762
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04190823
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04190823
53GDP-mannose metabolic process (GO:0019673)3.03551741
54rRNA metabolic process (GO:0016072)3.02239180
55behavioral response to nicotine (GO:0035095)3.01451666
56signal transduction involved in cell cycle checkpoint (GO:0072395)3.00659444
57purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99944567
58actin-myosin filament sliding (GO:0033275)2.99823536
59muscle filament sliding (GO:0030049)2.99823536
60purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.95522125
61cellular ketone body metabolic process (GO:0046950)2.93150865
62positive regulation of prostaglandin secretion (GO:0032308)2.91057926
63regulation of regulatory T cell differentiation (GO:0045589)2.90444602
64protein deneddylation (GO:0000338)2.89995886
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.89234875
66termination of RNA polymerase III transcription (GO:0006386)2.89234875
67skeletal muscle tissue regeneration (GO:0043403)2.88304077
68rRNA methylation (GO:0031167)2.87802326
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87111209
70negative regulation of ligase activity (GO:0051352)2.87111209
71protein polyglutamylation (GO:0018095)2.84831834
72ATP biosynthetic process (GO:0006754)2.83343064
73regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82362423
74protein neddylation (GO:0045116)2.82274083
75respiratory chain complex IV assembly (GO:0008535)2.80411915
76interferon-gamma production (GO:0032609)2.79415999
77ribosomal large subunit biogenesis (GO:0042273)2.77317615
78maturation of 5.8S rRNA (GO:0000460)2.77099264
79positive regulation of defense response to virus by host (GO:0002230)2.75543004
80cullin deneddylation (GO:0010388)2.73235175
81UTP biosynthetic process (GO:0006228)2.73166057
82negative regulation of skeletal muscle tissue development (GO:0048642)2.70841053
83UTP metabolic process (GO:0046051)2.70112444
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69810217
85ribosome biogenesis (GO:0042254)2.66945216
86sulfation (GO:0051923)2.65708076
87cellular component biogenesis (GO:0044085)2.65649559
88ketone body metabolic process (GO:1902224)2.63918441
89regulation of isotype switching to IgG isotypes (GO:0048302)2.63087011
90piRNA metabolic process (GO:0034587)2.62805401
91DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.60456209
92xenobiotic catabolic process (GO:0042178)2.58040052
93platelet dense granule organization (GO:0060155)2.57334237
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56578838
95positive regulation of cell cycle arrest (GO:0071158)2.56445621
96DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.55502422
97translation (GO:0006412)2.55465839
98tRNA processing (GO:0008033)2.55268595
99cytochrome complex assembly (GO:0017004)2.53325238
100retina homeostasis (GO:0001895)2.51119419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.24989380
2VDR_22108803_ChIP-Seq_LS180_Human4.96851553
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.98840336
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.96584023
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.63927900
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39440060
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.28525612
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.21290201
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66318953
10ZNF274_21170338_ChIP-Seq_K562_Hela2.62968632
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.47540755
12VDR_23849224_ChIP-Seq_CD4+_Human2.44856468
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42267290
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.40331332
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.29348472
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23784592
17TAF15_26573619_Chip-Seq_HEK293_Human2.16421335
18ELK1_19687146_ChIP-ChIP_HELA_Human2.02144746
19FOXP3_21729870_ChIP-Seq_TREG_Human1.96825791
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96396299
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.95571395
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.92729650
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90662232
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90481707
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82392926
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77014631
27FUS_26573619_Chip-Seq_HEK293_Human1.70566684
28EWS_26573619_Chip-Seq_HEK293_Human1.70472270
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69493692
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.69215887
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64767872
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62168382
33TP53_22573176_ChIP-Seq_HFKS_Human1.60060762
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.58083278
35IRF1_19129219_ChIP-ChIP_H3396_Human1.56716118
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53964621
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49677231
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45636419
39MYC_18940864_ChIP-ChIP_HL60_Human1.45445798
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.44383692
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42968113
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42433766
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.39741612
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39388246
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.39067686
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38876722
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33019300
48ER_23166858_ChIP-Seq_MCF-7_Human1.32087414
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31515254
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.26883634
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25412363
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24145885
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23712058
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23171453
55IGF1R_20145208_ChIP-Seq_DFB_Human1.19794316
56DCP1A_22483619_ChIP-Seq_HELA_Human1.18104501
57AR_20517297_ChIP-Seq_VCAP_Human1.17153383
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16615940
59P300_19829295_ChIP-Seq_ESCs_Human1.16612959
60TTF2_22483619_ChIP-Seq_HELA_Human1.16515869
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16014899
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12535688
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11523418
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10893966
65CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10279936
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07495230
67NCOR_22424771_ChIP-Seq_293T_Human1.06967418
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06405041
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.06405041
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05387001
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03337948
72NANOG_19829295_ChIP-Seq_ESCs_Human1.03328362
73SOX2_19829295_ChIP-Seq_ESCs_Human1.03328362
74AR_21572438_ChIP-Seq_LNCaP_Human0.98769940
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98108210
76ERG_20517297_ChIP-Seq_VCAP_Human0.97607330
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.97048927
78MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96951535
79GATA3_26560356_Chip-Seq_TH2_Human0.96788316
80FOXH1_21741376_ChIP-Seq_EPCs_Human0.96525263
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95655783
82CBP_20019798_ChIP-Seq_JUKART_Human0.95655783
83TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95335408
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94484222
85STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94054395
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93473228
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92669598
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91739724
89BCAT_22108803_ChIP-Seq_LS180_Human0.91515528
90CDX2_22108803_ChIP-Seq_LS180_Human0.91200363
91NANOG_20526341_ChIP-Seq_ESCs_Human0.90136105
92MYC_19829295_ChIP-Seq_ESCs_Human0.89424797
93MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88635795
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88580477
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87974155
96TCF4_22108803_ChIP-Seq_LS180_Human0.87183221
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84286533
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83989749
99GATA3_21878914_ChIP-Seq_MCF-7_Human0.80758940
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80537656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.61119414
2MP0004145_abnormal_muscle_electrophysio3.11846579
3MP0002638_abnormal_pupillary_reflex2.95055101
4MP0002102_abnormal_ear_morphology2.77581962
5MP0005671_abnormal_response_to2.71472823
6MP0005360_urolithiasis2.54425465
7MP0001835_abnormal_antigen_presentation2.42618404
8MP0004147_increased_porphyrin_level2.42297679
9MP0008875_abnormal_xenobiotic_pharmacok2.41088143
10MP0006072_abnormal_retinal_apoptosis2.38219180
11MP0003646_muscle_fatigue2.33609845
12MP0005645_abnormal_hypothalamus_physiol2.26119744
13MP0005084_abnormal_gallbladder_morpholo2.22950697
14MP0000747_muscle_weakness2.20117197
15MP0008872_abnormal_physiological_respon2.19070624
16MP0002139_abnormal_hepatobiliary_system2.09951779
17MP0008877_abnormal_DNA_methylation2.05440716
18MP0003195_calcinosis2.02053156
19MP0005085_abnormal_gallbladder_physiolo2.01076965
20MP0000685_abnormal_immune_system1.87533097
21MP0003786_premature_aging1.85947394
22MP0002736_abnormal_nociception_after1.80370180
23MP0005167_abnormal_blood-brain_barrier1.80092037
24MP0000372_irregular_coat_pigmentation1.77799662
25MP0003718_maternal_effect1.76831530
26MP0001968_abnormal_touch/_nociception1.76584944
27MP0003252_abnormal_bile_duct1.70441920
28MP0002876_abnormal_thyroid_physiology1.69024894
29MP0004885_abnormal_endolymph1.64573212
30MP0003806_abnormal_nucleotide_metabolis1.63820243
31MP0001873_stomach_inflammation1.63648388
32MP0002089_abnormal_postnatal_growth/wei1.62408103
33MP0003283_abnormal_digestive_organ1.60446340
34MP0002148_abnormal_hypersensitivity_rea1.55920121
35MP0004036_abnormal_muscle_relaxation1.52524263
36MP0001790_abnormal_immune_system1.46790444
37MP0005387_immune_system_phenotype1.46790444
38MP0005083_abnormal_biliary_tract1.43161407
39MP0005551_abnormal_eye_electrophysiolog1.41970065
40MP0002277_abnormal_respiratory_mucosa1.40439010
41MP0005253_abnormal_eye_physiology1.31650818
42MP0008058_abnormal_DNA_repair1.30910800
43MP0004043_abnormal_pH_regulation1.29307640
44MP0010155_abnormal_intestine_physiology1.27355004
45MP0006292_abnormal_olfactory_placode1.27294594
46MP0003959_abnormal_lean_body1.23020989
47MP0006035_abnormal_mitochondrial_morpho1.20144931
48MP0000427_abnormal_hair_cycle1.19501631
49MP0001800_abnormal_humoral_immune1.18650274
50MP0002837_dystrophic_cardiac_calcinosis1.17522519
51MP0009764_decreased_sensitivity_to1.15432615
52MP0001348_abnormal_lacrimal_gland1.14123677
53MP0009333_abnormal_splenocyte_physiolog1.10786736
54MP0002166_altered_tumor_susceptibility1.10573464
55MP0004142_abnormal_muscle_tone1.08442395
56MP0004019_abnormal_vitamin_homeostasis1.06254674
57MP0009785_altered_susceptibility_to1.02240996
58MP0006036_abnormal_mitochondrial_physio1.01562104
59MP0002269_muscular_atrophy1.01177184
60MP0001905_abnormal_dopamine_level1.00842551
61MP0005636_abnormal_mineral_homeostasis1.00133149
62MP0001986_abnormal_taste_sensitivity0.99784756
63MP0002006_tumorigenesis0.99438881
64MP0005389_reproductive_system_phenotype0.97087848
65MP0003866_abnormal_defecation0.97044834
66MP0005000_abnormal_immune_tolerance0.95798187
67MP0005332_abnormal_amino_acid0.92915497
68MP0004957_abnormal_blastocyst_morpholog0.92899259
69MP0001661_extended_life_span0.92887870
70MP0002723_abnormal_immune_serum0.92277448
71MP0002095_abnormal_skin_pigmentation0.90981989
72MP0008995_early_reproductive_senescence0.90775125
73MP0000013_abnormal_adipose_tissue0.90351916
74MP0002160_abnormal_reproductive_system0.89939509
75MP0005365_abnormal_bile_salt0.89379594
76MP0005379_endocrine/exocrine_gland_phen0.86862194
77MP0001765_abnormal_ion_homeostasis0.84367345
78MP0001666_abnormal_nutrient_absorption0.83214265
79MP0003937_abnormal_limbs/digits/tail_de0.82767442
80MP0005075_abnormal_melanosome_morpholog0.82283244
81MP0001919_abnormal_reproductive_system0.81783999
82MP0002938_white_spotting0.81456296
83MP0004215_abnormal_myocardial_fiber0.80594860
84MP0001501_abnormal_sleep_pattern0.80588697
85MP0002106_abnormal_muscle_physiology0.79925086
86MP0010329_abnormal_lipoprotein_level0.78130394
87MP0001764_abnormal_homeostasis0.77586026
88MP0000631_abnormal_neuroendocrine_gland0.75873315
89MP0002420_abnormal_adaptive_immunity0.75330271
90MP0000465_gastrointestinal_hemorrhage0.74493062
91MP0001819_abnormal_immune_cell0.72936069
92MP0000569_abnormal_digit_pigmentation0.72837706
93MP0005646_abnormal_pituitary_gland0.72238166
94MP0001529_abnormal_vocalization0.71933839
95MP0003724_increased_susceptibility_to0.71628478
96MP0005620_abnormal_muscle_contractility0.71276466
97MP0002693_abnormal_pancreas_physiology0.69607275
98MP0001119_abnormal_female_reproductive0.68560775
99MP0003011_delayed_dark_adaptation0.68012541
100MP0002272_abnormal_nervous_system0.67927548

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)3.67351162
2Acute necrotizing encephalopathy (HP:0006965)3.53226539
33-Methylglutaconic aciduria (HP:0003535)3.41567777
4Increased CSF lactate (HP:0002490)3.34226978
5Mitochondrial inheritance (HP:0001427)3.31489936
6Acute encephalopathy (HP:0006846)3.25571089
7Congenital stationary night blindness (HP:0007642)3.22422122
8Absent phalangeal crease (HP:0006109)3.20435820
9Progressive macrocephaly (HP:0004481)3.12163288
10Increased hepatocellular lipid droplets (HP:0006565)3.07454891
11Hepatic necrosis (HP:0002605)3.05181826
12IgG deficiency (HP:0004315)3.01027470
13Lipid accumulation in hepatocytes (HP:0006561)2.96616984
14Abnormal mitochondria in muscle tissue (HP:0008316)2.92097753
15Abnormality of the renal cortex (HP:0011035)2.91530455
16Stomatitis (HP:0010280)2.89157727
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.84403537
18Abnormality of alanine metabolism (HP:0010916)2.84403537
19Hyperalaninemia (HP:0003348)2.84403537
20Hepatocellular necrosis (HP:0001404)2.81773945
21Distal arthrogryposis (HP:0005684)2.81753643
22Methylmalonic acidemia (HP:0002912)2.79325736
23Renal cortical cysts (HP:0000803)2.72813239
24Abolished electroretinogram (ERG) (HP:0000550)2.69073067
25Abnormal finger flexion creases (HP:0006143)2.67826484
26Renal Fanconi syndrome (HP:0001994)2.64898672
27Increased serum lactate (HP:0002151)2.64745703
28Congenital, generalized hypertrichosis (HP:0004540)2.62775819
29Decreased circulating renin level (HP:0003351)2.62620921
30Methylmalonic aciduria (HP:0012120)2.59421364
31Ulnar deviation of the wrist (HP:0003049)2.58635217
32Pancreatic cysts (HP:0001737)2.57326488
33Round ear (HP:0100830)2.56804845
34Delayed CNS myelination (HP:0002188)2.55008847
35Cerebral edema (HP:0002181)2.54112327
36Abnormality of urine glucose concentration (HP:0011016)2.53339257
37Glycosuria (HP:0003076)2.53339257
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47786487
39Abnormality of midbrain morphology (HP:0002418)2.41508698
40Molar tooth sign on MRI (HP:0002419)2.41508698
41Hypoplasia of the pons (HP:0012110)2.40069849
42Abnormality of the pons (HP:0007361)2.37649255
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36840763
44Nephronophthisis (HP:0000090)2.34277019
45Optic disc pallor (HP:0000543)2.28321960
46Dicarboxylic aciduria (HP:0003215)2.28264744
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28264744
48Aplasia/hypoplasia of the uterus (HP:0008684)2.27957202
49Lactic acidosis (HP:0003128)2.27124845
50Nemaline bodies (HP:0003798)2.26512655
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24998324
52Metabolic acidosis (HP:0001942)2.23286217
53Colon cancer (HP:0003003)2.23233844
54Abnormal rod and cone electroretinograms (HP:0008323)2.19313389
55Abnormality of the renal medulla (HP:0100957)2.18124933
56Lethargy (HP:0001254)2.17793355
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.17165156
58Elevated erythrocyte sedimentation rate (HP:0003565)2.16626725
59Hypoglycemic coma (HP:0001325)2.12909341
60Pancreatic fibrosis (HP:0100732)2.10855458
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.10210944
62Hyperglycinemia (HP:0002154)2.08866491
63Abnormality of vitamin B metabolism (HP:0004340)2.08151516
64Generalized aminoaciduria (HP:0002909)2.07962893
65Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07902336
66Abnormality of the prostate (HP:0008775)2.04962339
67Hypobetalipoproteinemia (HP:0003563)2.04812124
68Hypoproteinemia (HP:0003075)2.03626235
69True hermaphroditism (HP:0010459)2.01797420
70Type II lissencephaly (HP:0007260)2.00074272
71Abnormality of serum amino acid levels (HP:0003112)1.99708874
72Prostate neoplasm (HP:0100787)1.97589040
73Exertional dyspnea (HP:0002875)1.95762975
74Type I transferrin isoform profile (HP:0003642)1.93420419
75Attenuation of retinal blood vessels (HP:0007843)1.91194921
76Hypoplasia of the uterus (HP:0000013)1.90094011
77Chorioretinal atrophy (HP:0000533)1.89449426
78Abnormality of methionine metabolism (HP:0010901)1.88170840
79Decreased central vision (HP:0007663)1.87524839
80Abnormality of macular pigmentation (HP:0008002)1.85582775
81Pendular nystagmus (HP:0012043)1.84666994
82Mask-like facies (HP:0000298)1.83754909
83Stomach cancer (HP:0012126)1.83179215
84Abnormal biliary tract physiology (HP:0012439)1.83026687
85Bile duct proliferation (HP:0001408)1.83026687
86Abnormal drinking behavior (HP:0030082)1.82721924
87Polydipsia (HP:0001959)1.82721924
88Confusion (HP:0001289)1.81374569
89Alkalosis (HP:0001948)1.80976440
90Abnormality of the labia minora (HP:0012880)1.79663885
91Oral leukoplakia (HP:0002745)1.76032403
92Periorbital edema (HP:0100539)1.75614342
93Respiratory failure (HP:0002878)1.75167047
94Abnormal albumin level (HP:0012116)1.74902629
95Hypoalbuminemia (HP:0003073)1.74902629
96Reticulocytopenia (HP:0001896)1.74560917
97Metabolic alkalosis (HP:0200114)1.74413181
98Conjunctival hamartoma (HP:0100780)1.73559911
99Exercise intolerance (HP:0003546)1.72797546
100Absent thumb (HP:0009777)1.72585130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.27166726
2TLK14.09045730
3NUAK13.44288360
4VRK23.09725136
5TXK3.09539584
6TIE12.75881462
7MAP4K22.42708314
8FRK2.26053251
9WNK42.18206279
10VRK12.17458105
11ADRBK21.99860522
12GRK11.97468649
13MST41.96404044
14TAF11.93093698
15PHKG21.92039587
16PHKG11.92039587
17BUB11.83703740
18TSSK61.75374815
19TAOK31.71012521
20STK161.66487282
21EIF2AK31.63797180
22PINK11.61310390
23PASK1.47592279
24BMPR1B1.42810492
25BCKDK1.33255028
26OBSCN1.31514671
27SRPK11.30065528
28CAMKK21.22371965
29FES1.21968597
30TEC1.20435577
31CSNK1G31.17639200
32CSNK1G11.10661185
33PBK1.09986372
34TRIM281.06956944
35PLK31.01446281
36CSNK1G20.99871222
37MAP2K60.96440021
38STK390.93488717
39MAP4K10.92397644
40EIF2AK20.92161750
41RPS6KA50.92106176
42MAP3K120.92042082
43IKBKB0.90478545
44ACVR1B0.89398546
45PIK3CG0.87971233
46ITK0.86121574
47NME10.86047825
48CSNK1A1L0.85551884
49NME20.85334161
50OXSR10.84051832
51PDK20.83058016
52FER0.82873351
53TGFBR10.81485984
54MKNK10.81070833
55WNK30.76791832
56IRAK10.75383249
57TNIK0.74658478
58EIF2AK10.74178581
59NLK0.72363832
60DAPK10.72074134
61INSRR0.71587903
62MKNK20.67247035
63DYRK20.63211299
64JAK30.63087778
65CHEK20.62974838
66PRKCQ0.57817819
67KIT0.57670606
68MAPK130.57006338
69AURKA0.53424678
70FGFR20.53189762
71MAP3K40.52255804
72MAP2K20.51869254
73ATR0.50986743
74PIK3CA0.50022497
75MAP3K140.47230523
76STK40.46361525
77SYK0.45271176
78MAPKAPK50.43734091
79MAP2K70.41823218
80CCNB10.41812017
81GRK60.37621996
82ERBB30.37461547
83CSNK1A10.35470959
84MYLK0.34561983
85WNK10.33926092
86DAPK30.33651540
87EPHA30.33182853
88ALK0.32660804
89CSNK2A10.31963913
90CHUK0.31941291
91LCK0.31641164
92IGF1R0.30683935
93PRKCA0.30154824
94ADRBK10.30130401
95PRKACA0.29987257
96STK30.29308454
97PRKCG0.29301432
98NEK10.29044419
99PLK10.28847559
100MAPKAPK30.28624117

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.08579887
2Asthma_Homo sapiens_hsa053103.01595365
3Ribosome_Homo sapiens_hsa030102.84160247
4Allograft rejection_Homo sapiens_hsa053302.48987591
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.43352578
6Oxidative phosphorylation_Homo sapiens_hsa001902.38734952
7Autoimmune thyroid disease_Homo sapiens_hsa053202.28836632
8RNA polymerase_Homo sapiens_hsa030202.25004062
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15217338
10Nitrogen metabolism_Homo sapiens_hsa009102.01939211
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98383299
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.95325358
13Parkinsons disease_Homo sapiens_hsa050121.92870859
14Protein export_Homo sapiens_hsa030601.86982780
15Type I diabetes mellitus_Homo sapiens_hsa049401.85777792
16Sulfur metabolism_Homo sapiens_hsa009201.85682103
17Graft-versus-host disease_Homo sapiens_hsa053321.84376418
18Systemic lupus erythematosus_Homo sapiens_hsa053221.82755094
19RNA degradation_Homo sapiens_hsa030181.80501571
20Linoleic acid metabolism_Homo sapiens_hsa005911.56662895
21Regulation of autophagy_Homo sapiens_hsa041401.56452599
22Caffeine metabolism_Homo sapiens_hsa002321.54686417
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41393560
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39988329
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37788178
26Homologous recombination_Homo sapiens_hsa034401.37334142
27Fat digestion and absorption_Homo sapiens_hsa049751.33717353
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.33603121
29Basal transcription factors_Homo sapiens_hsa030221.32294614
30Primary immunodeficiency_Homo sapiens_hsa053401.31581497
31Tryptophan metabolism_Homo sapiens_hsa003801.30050121
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29749828
33Mismatch repair_Homo sapiens_hsa034301.28792493
34Antigen processing and presentation_Homo sapiens_hsa046121.22634502
35Peroxisome_Homo sapiens_hsa041461.21533518
36Propanoate metabolism_Homo sapiens_hsa006401.20968436
37Alzheimers disease_Homo sapiens_hsa050101.20209503
38One carbon pool by folate_Homo sapiens_hsa006701.19000395
39Fanconi anemia pathway_Homo sapiens_hsa034601.18103422
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17618687
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17079692
42Huntingtons disease_Homo sapiens_hsa050161.13686028
43Purine metabolism_Homo sapiens_hsa002301.12697930
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11678908
45Vitamin digestion and absorption_Homo sapiens_hsa049771.10394134
46Spliceosome_Homo sapiens_hsa030401.09368127
47Pyrimidine metabolism_Homo sapiens_hsa002401.05114782
48Arginine biosynthesis_Homo sapiens_hsa002201.04832688
49Butanoate metabolism_Homo sapiens_hsa006501.03233883
50Phototransduction_Homo sapiens_hsa047441.02286506
51RNA transport_Homo sapiens_hsa030131.01631886
52Selenocompound metabolism_Homo sapiens_hsa004501.00007015
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93988884
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93643773
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92900571
56Cardiac muscle contraction_Homo sapiens_hsa042600.91044491
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89868444
58Chemical carcinogenesis_Homo sapiens_hsa052040.89197607
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86310120
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84953325
61Glutathione metabolism_Homo sapiens_hsa004800.84828458
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.83367913
63Ether lipid metabolism_Homo sapiens_hsa005650.81024439
64Nucleotide excision repair_Homo sapiens_hsa034200.80756462
65Rheumatoid arthritis_Homo sapiens_hsa053230.78895346
66Arachidonic acid metabolism_Homo sapiens_hsa005900.78451095
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76333140
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72660187
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72288412
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70330921
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66600136
72Retinol metabolism_Homo sapiens_hsa008300.61808560
73DNA replication_Homo sapiens_hsa030300.58870593
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57023305
75Metabolic pathways_Homo sapiens_hsa011000.56040425
76Alcoholism_Homo sapiens_hsa050340.54841056
77Base excision repair_Homo sapiens_hsa034100.52455791
78Pyruvate metabolism_Homo sapiens_hsa006200.49792047
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48938124
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46902027
81Hematopoietic cell lineage_Homo sapiens_hsa046400.46241633
82Tight junction_Homo sapiens_hsa045300.45508045
83Non-homologous end-joining_Homo sapiens_hsa034500.45003532
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.44566256
85Mineral absorption_Homo sapiens_hsa049780.41644975
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41600972
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40179028
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39986757
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.39001446
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.38830994
91Arginine and proline metabolism_Homo sapiens_hsa003300.36574290
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36290182
93Vitamin B6 metabolism_Homo sapiens_hsa007500.33844935
94Fatty acid elongation_Homo sapiens_hsa000620.31555942
95Olfactory transduction_Homo sapiens_hsa047400.31002479
96Carbon metabolism_Homo sapiens_hsa012000.30137905
97Epstein-Barr virus infection_Homo sapiens_hsa051690.29374594
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.29195497
99Viral myocarditis_Homo sapiens_hsa054160.29180157
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28083312

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