ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.57585902
2	ATP synthesis coupled proton transport (GO:0015986)	4.64218886
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.64218886
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.44425583
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.27086001
6	positive regulation of prostaglandin secretion (GO:0032308)	4.11685827
7	proteasome assembly (GO:0043248)	4.06010466
8	ribosomal small subunit assembly (GO:0000028)	3.80163744
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.78947782
10	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.51537242
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.51537242
12	behavioral response to nicotine (GO:0035095)	3.48809364
13	rRNA modification (GO:0000154)	3.48761591
14	protein neddylation (GO:0045116)	3.46847974
15	fucose catabolic process (GO:0019317)	3.37035411
16	L-fucose metabolic process (GO:0042354)	3.37035411
17	L-fucose catabolic process (GO:0042355)	3.37035411
18	viral transcription (GO:0019083)	3.34824761
19	piRNA metabolic process (GO:0034587)	3.33289076
20	regulation of prostaglandin secretion (GO:0032306)	3.31159122
21	protein complex biogenesis (GO:0070271)	3.30969045
22	translational termination (GO:0006415)	3.29294621
23	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.28755757
24	respiratory chain complex IV assembly (GO:0008535)	3.27298414
25	platelet dense granule organization (GO:0060155)	3.23416943
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.21641142
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.19856771
28	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.18244479
29	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13976249
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.13167639
31	ribosomal large subunit biogenesis (GO:0042273)	3.11224075
32	positive regulation of fatty acid transport (GO:2000193)	3.09962097
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09231893
34	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09231893
35	NADH dehydrogenase complex assembly (GO:0010257)	3.09231893
36	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.08494746
37	pseudouridine synthesis (GO:0001522)	3.07348968
38	translational elongation (GO:0006414)	3.04787232
39	maturation of SSU-rRNA (GO:0030490)	3.04348122
40	cotranslational protein targeting to membrane (GO:0006613)	3.03202198
41	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.02103218
42	GTP biosynthetic process (GO:0006183)	2.99811422
43	positive regulation of icosanoid secretion (GO:0032305)	2.98762228
44	protein targeting to ER (GO:0045047)	2.98509583
45	chaperone-mediated protein transport (GO:0072321)	2.94711585
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.90960892
47	positive regulation of defense response to virus by host (GO:0002230)	2.90352792
48	tRNA processing (GO:0008033)	2.88205167
49	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.87511303
50	isotype switching (GO:0045190)	2.87511303
51	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.87511303
52	indolalkylamine metabolic process (GO:0006586)	2.87058899
53	regulation of mitotic spindle checkpoint (GO:1903504)	2.86686190
54	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.86686190
55	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.86518547
56	regulation of regulatory T cell differentiation (GO:0045589)	2.85899610
57	cytochrome complex assembly (GO:0017004)	2.85623047
58	rRNA methylation (GO:0031167)	2.84951765
59	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.83390418
60	protein localization to endoplasmic reticulum (GO:0070972)	2.82902978
61	termination of RNA polymerase III transcription (GO:0006386)	2.82796703
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.82796703
63	protein K6-linked ubiquitination (GO:0085020)	2.82059455
64	cytidine metabolic process (GO:0046087)	2.80363782
65	cytidine catabolic process (GO:0006216)	2.80363782
66	cytidine deamination (GO:0009972)	2.80363782
67	translation (GO:0006412)	2.78559443
68	replication fork processing (GO:0031297)	2.76600229
69	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75410238
70	electron transport chain (GO:0022900)	2.72907708
71	rRNA metabolic process (GO:0016072)	2.72692878
72	tryptophan catabolic process (GO:0006569)	2.72517584
73	indole-containing compound catabolic process (GO:0042436)	2.72517584
74	indolalkylamine catabolic process (GO:0046218)	2.72517584
75	translational initiation (GO:0006413)	2.71205517
76	rRNA processing (GO:0006364)	2.71188138
77	negative regulation of mast cell activation (GO:0033004)	2.70419565
78	protein-cofactor linkage (GO:0018065)	2.69624758
79	regulation of immunoglobulin secretion (GO:0051023)	2.69415172
80	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.69277464
81	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.69277464
82	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.69277464
83	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.68685998
84	rRNA catabolic process (GO:0016075)	2.67586605
85	regulation of memory T cell differentiation (GO:0043380)	2.67001505
86	respiratory electron transport chain (GO:0022904)	2.66232342
87	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66052782
88	cullin deneddylation (GO:0010388)	2.65515467
89	tryptophan metabolic process (GO:0006568)	2.64929348
90	regulation of cellular amino acid metabolic process (GO:0006521)	2.64018252
91	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.63628871
92	regulation of isotype switching to IgG isotypes (GO:0048302)	2.63267135
93	maturation of 5.8S rRNA (GO:0000460)	2.63183759
94	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.61172279
95	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.58171568
96	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.58171568
97	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.57628119
98	tRNA metabolic process (GO:0006399)	2.55740422
99	hydrogen ion transmembrane transport (GO:1902600)	2.52711918
100	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.52322845

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.07337493
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.06167696
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.85581261
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.49191932
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.98155832
6	VDR_22108803_ChIP-Seq_LS180_Human	2.95571960
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91571108
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.84086342
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.77966754
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.72216324
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.52645056
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.52165439
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.51852010
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46903781
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.45806417
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.25278869
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.22515221
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16761491
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01893087
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99358972
21	EWS_26573619_Chip-Seq_HEK293_Human	1.96667147
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87091964
23	FUS_26573619_Chip-Seq_HEK293_Human	1.77952653
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.77874251
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74320348
26	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.73234994
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71034396
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.68539206
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.66855135
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.62627156
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.61974987
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58543125
33	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.57918970
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57269175
35	P300_19829295_ChIP-Seq_ESCs_Human	1.56045831
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.51275587
37	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.50674261
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.50513511
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50089754
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49235134
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.48226074
42	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.48149623
43	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.46218059
44	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.46200002
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43872981
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43872981
47	GATA3_26560356_Chip-Seq_TH2_Human	1.40882976
48	ER_23166858_ChIP-Seq_MCF-7_Human	1.39506828
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.39472135
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33670610
51	AR_20517297_ChIP-Seq_VCAP_Human	1.32978916
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32612519
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31320248
54	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.30944465
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30057218
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30057218
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29986963
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29930148
59	IGF1R_20145208_ChIP-Seq_DFB_Human	1.29190360
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24534629
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24193415
62	TTF2_22483619_ChIP-Seq_HELA_Human	1.22758017
63	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.18722776
64	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17213122
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16616712
66	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16270982
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14897766
68	NCOR_22424771_ChIP-Seq_293T_Human	1.13153698
69	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13097234
70	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11154847
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06727956
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04631502
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02252034
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01134073
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.01134073
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00390994
77	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97966374
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96979028
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96460472
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96059940
81	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.96036563
82	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95916829
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95390011
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94861215
85	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.94820004
86	MYB_26560356_Chip-Seq_TH2_Human	0.94094150
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93044835
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93033217
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.91664016
90	TCF4_22108803_ChIP-Seq_LS180_Human	0.89595620
91	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.88248116
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.87870039
93	BCAT_22108803_ChIP-Seq_LS180_Human	0.87619547
94	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.87584420
95	MYC_19829295_ChIP-Seq_ESCs_Human	0.87365971
96	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87136641
97	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87098608
98	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.86931536
99	DCP1A_22483619_ChIP-Seq_HELA_Human	0.86922924
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.86908939

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.55326276
2	MP0001835_abnormal_antigen_presentation	2.97328872
3	MP0005671_abnormal_response_to	2.93517197
4	MP0004147_increased_porphyrin_level	2.68372772
5	MP0008877_abnormal_DNA_methylation	2.64991180
6	MP0002138_abnormal_hepatobiliary_system	2.49448975
7	MP0004885_abnormal_endolymph	2.41586985
8	MP0001968_abnormal_touch/_nociception	2.41155665
9	MP0006072_abnormal_retinal_apoptosis	2.40736391
10	MP0006292_abnormal_olfactory_placode	2.27003857
11	MP0008872_abnormal_physiological_respon	2.18960452
12	MP0003195_calcinosis	1.99879192
13	MP0008058_abnormal_DNA_repair	1.99760981
14	MP0000372_irregular_coat_pigmentation	1.92419785
15	MP0002736_abnormal_nociception_after	1.88601578
16	MP0008875_abnormal_xenobiotic_pharmacok	1.88550933
17	MP0003806_abnormal_nucleotide_metabolis	1.79253320
18	MP0005084_abnormal_gallbladder_morpholo	1.76370679
19	MP0002148_abnormal_hypersensitivity_rea	1.73778085
20	MP0003283_abnormal_digestive_organ	1.67818409
21	MP0005646_abnormal_pituitary_gland	1.63572918
22	MP0001800_abnormal_humoral_immune	1.59988951
23	MP0003718_maternal_effect	1.59673192
24	MP0002277_abnormal_respiratory_mucosa	1.59474485
25	MP0009333_abnormal_splenocyte_physiolog	1.58234167
26	MP0003011_delayed_dark_adaptation	1.55691543
27	MP0005360_urolithiasis	1.54524025
28	MP0009785_altered_susceptibility_to	1.54369287
29	MP0000685_abnormal_immune_system	1.54146957
30	MP0002876_abnormal_thyroid_physiology	1.52772685
31	MP0005075_abnormal_melanosome_morpholog	1.48718410
32	MP0003786_premature_aging	1.46469714
33	MP0005645_abnormal_hypothalamus_physiol	1.46353335
34	MP0001501_abnormal_sleep_pattern	1.43025071
35	MP0002938_white_spotting	1.41333226
36	MP0005253_abnormal_eye_physiology	1.41292907
37	MP0003866_abnormal_defecation	1.37352869
38	MP0001986_abnormal_taste_sensitivity	1.37265739
39	MP0009764_decreased_sensitivity_to	1.34153518
40	MP0001790_abnormal_immune_system	1.33445266
41	MP0005387_immune_system_phenotype	1.33445266
42	MP0001905_abnormal_dopamine_level	1.33228764
43	MP0002837_dystrophic_cardiac_calcinosis	1.31129230
44	MP0001873_stomach_inflammation	1.30958094
45	MP0003252_abnormal_bile_duct	1.30175195
46	MP0005551_abnormal_eye_electrophysiolog	1.29859826
47	MP0005000_abnormal_immune_tolerance	1.27573735
48	MP0006036_abnormal_mitochondrial_physio	1.21830676
49	MP0002723_abnormal_immune_serum	1.20061684
50	MP0000569_abnormal_digit_pigmentation	1.19586273
51	MP0005085_abnormal_gallbladder_physiolo	1.17002361
52	MP0004142_abnormal_muscle_tone	1.14523382
53	MP0009379_abnormal_foot_pigmentation	1.14237663
54	MP0004145_abnormal_muscle_electrophysio	1.12496178
55	MP0000465_gastrointestinal_hemorrhage	1.12292552
56	MP0002638_abnormal_pupillary_reflex	1.10057164
57	MP0002452_abnormal_antigen_presenting	1.08927764
58	MP0002166_altered_tumor_susceptibility	1.08709797
59	MP0003693_abnormal_embryo_hatching	1.08054404
60	MP0003763_abnormal_thymus_physiology	1.04652581
61	MP0001819_abnormal_immune_cell	1.03661687
62	MP0001919_abnormal_reproductive_system	1.02861967
63	MP0002006_tumorigenesis	1.02860060
64	MP0008995_early_reproductive_senescence	1.02626418
65	MP0002420_abnormal_adaptive_immunity	1.01263815
66	MP0000383_abnormal_hair_follicle	1.00725856
67	MP0003186_abnormal_redox_activity	0.98922427
68	MP0000631_abnormal_neuroendocrine_gland	0.98051002
69	MP0000427_abnormal_hair_cycle	0.97892796
70	MP0005389_reproductive_system_phenotype	0.96949529
71	MP0003724_increased_susceptibility_to	0.95997833
72	MP0010155_abnormal_intestine_physiology	0.94512567
73	MP0002163_abnormal_gland_morphology	0.93494849
74	MP0002751_abnormal_autonomic_nervous	0.91786702
75	MP0001765_abnormal_ion_homeostasis	0.91034735
76	MP0005167_abnormal_blood-brain_barrier	0.90972535
77	MP0001845_abnormal_inflammatory_respons	0.90713879
78	MP0005636_abnormal_mineral_homeostasis	0.89575181
79	MP0005332_abnormal_amino_acid	0.89527947
80	MP0000538_abnormal_urinary_bladder	0.87355335
81	MP0003638_abnormal_response/metabolism_	0.86000304
82	MP0005379_endocrine/exocrine_gland_phen	0.84388093
83	MP0010386_abnormal_urinary_bladder	0.83927336
84	MP0000689_abnormal_spleen_morphology	0.83875012
85	MP0002693_abnormal_pancreas_physiology	0.83007285
86	MP0003787_abnormal_imprinting	0.81238080
87	MP0003567_abnormal_fetal_cardiomyocyte	0.77905593
88	MP0010094_abnormal_chromosome_stability	0.77703610
89	MP0002272_abnormal_nervous_system	0.76329399
90	MP0000566_synostosis	0.75640328
91	MP0001293_anophthalmia	0.74837226
92	MP0000230_abnormal_systemic_arterial	0.74631231
93	MP0009697_abnormal_copulation	0.73995113
94	MP0002398_abnormal_bone_marrow	0.73961045
95	MP0004133_heterotaxia	0.73394955
96	MP0000716_abnormal_immune_system	0.73124095
97	MP0002928_abnormal_bile_duct	0.72926086
98	MP0005365_abnormal_bile_salt	0.72743726
99	MP0001529_abnormal_vocalization	0.72650775
100	MP0001764_abnormal_homeostasis	0.72449135

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.60825630
2	IgG deficiency (HP:0004315)	3.44874375
3	Pancreatic cysts (HP:0001737)	3.31571933
4	Stomatitis (HP:0010280)	3.25614487
5	Mitochondrial inheritance (HP:0001427)	3.23131043
6	Acute encephalopathy (HP:0006846)	3.19417467
7	Increased CSF lactate (HP:0002490)	3.17846700
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14351479
9	Progressive macrocephaly (HP:0004481)	3.08659886
10	Methylmalonic acidemia (HP:0002912)	2.93836375
11	Abnormality of the renal cortex (HP:0011035)	2.87164971
12	Congenital stationary night blindness (HP:0007642)	2.79379564
13	Increased hepatocellular lipid droplets (HP:0006565)	2.77065688
14	Hypothermia (HP:0002045)	2.75947885
15	Renal cortical cysts (HP:0000803)	2.75140501
16	Lipid accumulation in hepatocytes (HP:0006561)	2.73347198
17	Abnormal number of erythroid precursors (HP:0012131)	2.72199064
18	Pancreatic fibrosis (HP:0100732)	2.68588215
19	Hepatocellular necrosis (HP:0001404)	2.66075040
20	Nephronophthisis (HP:0000090)	2.64592414
21	Abnormality of the labia minora (HP:0012880)	2.63207802
22	Abnormality of midbrain morphology (HP:0002418)	2.63090004
23	Molar tooth sign on MRI (HP:0002419)	2.63090004
24	Hepatic necrosis (HP:0002605)	2.62279368
25	Stomach cancer (HP:0012126)	2.61018229
26	Elevated erythrocyte sedimentation rate (HP:0003565)	2.58674634
27	Abolished electroretinogram (ERG) (HP:0000550)	2.58628180
28	Abnormality of the pons (HP:0007361)	2.57705236
29	True hermaphroditism (HP:0010459)	2.55824764
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54946716
31	Abnormality of alanine metabolism (HP:0010916)	2.54946716
32	Hyperalaninemia (HP:0003348)	2.54946716
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.50937646
34	Hypoplasia of the pons (HP:0012110)	2.43817691
35	Increased serum lactate (HP:0002151)	2.42742957
36	Optic disc pallor (HP:0000543)	2.39896936
37	Abnormality of the renal medulla (HP:0100957)	2.35249513
38	Reduced antithrombin III activity (HP:0001976)	2.33986716
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.32189424
40	Methylmalonic aciduria (HP:0012120)	2.31737574
41	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29329509
42	Cerebral edema (HP:0002181)	2.24883224
43	Congenital, generalized hypertrichosis (HP:0004540)	2.22781307
44	Hypoproteinemia (HP:0003075)	2.21979624
45	3-Methylglutaconic aciduria (HP:0003535)	2.18054478
46	Reticulocytopenia (HP:0001896)	2.16974696
47	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.16271093
48	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.16271093
49	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.15224922
50	Abnormality of the prostate (HP:0008775)	2.14774685
51	Attenuation of retinal blood vessels (HP:0007843)	2.14509349
52	Hypoglycemic seizures (HP:0002173)	2.13865186
53	Meckel diverticulum (HP:0002245)	2.13708117
54	Abnormality of the ileum (HP:0001549)	2.12534120
55	Renal Fanconi syndrome (HP:0001994)	2.08353821
56	Lactic acidosis (HP:0003128)	2.08311148
57	Polydipsia (HP:0001959)	2.08217458
58	Abnormal drinking behavior (HP:0030082)	2.08217458
59	Hyperglycinemia (HP:0002154)	2.06708253
60	Type II lissencephaly (HP:0007260)	2.06207101
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.03960758
62	Absent/shortened dynein arms (HP:0200106)	2.02820522
63	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.02820522
64	Colon cancer (HP:0003003)	2.00206743
65	Lethargy (HP:0001254)	1.99266822
66	Polyuria (HP:0000103)	1.98878281
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98483711
68	Abnormality of vitamin B metabolism (HP:0004340)	1.97914440
69	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.96897105
70	Asplenia (HP:0001746)	1.96415209
71	Panhypogammaglobulinemia (HP:0003139)	1.95850431
72	Abnormal rod and cone electroretinograms (HP:0008323)	1.95552474
73	Abnormality of serum amino acid levels (HP:0003112)	1.95362502
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.94202083
75	Type 2 muscle fiber atrophy (HP:0003554)	1.94171209
76	Exertional dyspnea (HP:0002875)	1.94157794
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.94107009
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.94107009
79	Abnormal protein glycosylation (HP:0012346)	1.94107009
80	Abnormal glycosylation (HP:0012345)	1.94107009
81	Increased intramyocellular lipid droplets (HP:0012240)	1.91523732
82	Abnormality of B cell number (HP:0010975)	1.90998333
83	Macrocytic anemia (HP:0001972)	1.90407658
84	Decreased circulating renin level (HP:0003351)	1.90273904
85	Type I transferrin isoform profile (HP:0003642)	1.88709968
86	Pendular nystagmus (HP:0012043)	1.87437901
87	Prostate neoplasm (HP:0100787)	1.86309547
88	Abnormality of T cell physiology (HP:0011840)	1.86189595
89	Constricted visual fields (HP:0001133)	1.85200060
90	Leukodystrophy (HP:0002415)	1.84759676
91	Abnormality of urine glucose concentration (HP:0011016)	1.82867015
92	Glycosuria (HP:0003076)	1.82867015
93	Abnormality of T cells (HP:0002843)	1.81260128
94	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80006472
95	Medial flaring of the eyebrow (HP:0010747)	1.79727065
96	Severe combined immunodeficiency (HP:0004430)	1.78788740
97	Hypoplasia of the uterus (HP:0000013)	1.76359765
98	Hypomagnesemia (HP:0002917)	1.76328150
99	Hyperglycinuria (HP:0003108)	1.75871220
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.72903293

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.38397244
2	ZAK	3.92103753
3	NUAK1	3.15745552
4	MAP4K2	2.92620742
5	TAOK3	2.68216638
6	MST4	2.54837075
7	ADRBK2	2.51109252
8	VRK2	2.38302306
9	TXK	2.19845777
10	GRK1	2.09983351
11	BUB1	2.08414425
12	BMPR1B	2.04315330
13	WNK4	1.99641798
14	TSSK6	1.82326982
15	EIF2AK3	1.81527536
16	FRK	1.77805675
17	PINK1	1.75859922
18	PASK	1.66180937
19	OXSR1	1.61446471
20	VRK1	1.60591158
21	TIE1	1.59069404
22	STK39	1.56923070
23	STK16	1.55093115
24	BCKDK	1.45894642
25	TEC	1.43655101
26	KIT	1.30407814
27	SRPK1	1.26048863
28	ACVR1B	1.22814249
29	TGFBR1	1.21575868
30	PBK	1.19476922
31	TRIM28	1.18955515
32	WNK3	1.16333436
33	MAP2K6	1.15645629
34	IKBKB	1.14600928
35	INSRR	1.12162989
36	CDK19	1.07548705
37	PLK3	1.03006994
38	MKNK1	1.01820889
39	TAF1	1.01586620
40	MAP4K1	0.99080586
41	ITK	0.97270164
42	PLK4	0.94837346
43	MKNK2	0.93227608
44	DYRK2	0.90240180
45	PNCK	0.88789785
46	GRK6	0.88233587
47	IKBKE	0.81590612
48	FES	0.81338687
49	TNIK	0.79420907
50	EIF2AK2	0.79360596
51	CSNK1G1	0.77184794
52	DAPK2	0.77048642
53	RPS6KA5	0.77045996
54	ERBB3	0.76065394
55	SYK	0.75141866
56	PHKG1	0.74876113
57	PHKG2	0.74876113
58	MAPK13	0.74118421
59	NEK1	0.70745544
60	NLK	0.69936741
61	ADRBK1	0.69710909
62	FLT3	0.63861924
63	MAP3K14	0.62937694
64	CSNK1G3	0.62766272
65	MAP3K12	0.58784766
66	CDK8	0.57397118
67	CSNK1G2	0.57085592
68	PRKCE	0.57079130
69	RPS6KA4	0.55614301
70	PRKCQ	0.55023702
71	LYN	0.54953151
72	BTK	0.51094303
73	ATR	0.51036728
74	PIK3CG	0.50931462
75	MAP2K2	0.50394533
76	LCK	0.47518755
77	WEE1	0.45808709
78	NME1	0.42768019
79	PLK2	0.42766457
80	IGF1R	0.42562739
81	DAPK1	0.42358014
82	BMPR2	0.40662595
83	CCNB1	0.40156324
84	CSF1R	0.39586830
85	EIF2AK1	0.39513320
86	BRSK2	0.39167051
87	ABL2	0.38120255
88	PRKCG	0.37253273
89	CSNK1A1L	0.36871691
90	CHUK	0.36755530
91	MUSK	0.36560686
92	MYLK	0.35925945
93	GRK7	0.35237603
94	FGFR2	0.34352570
95	OBSCN	0.33923073
96	PLK1	0.33869669
97	PIM1	0.33665695
98	MATK	0.33619147
99	CDC7	0.33504111
100	CSNK2A1	0.33077181

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.54067629
2	Proteasome_Homo sapiens_hsa03050	3.24949702
3	Ribosome_Homo sapiens_hsa03010	3.24219071
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.05117112
5	Allograft rejection_Homo sapiens_hsa05330	2.87842166
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79551830
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.67867316
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.38835097
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.30563257
10	RNA polymerase_Homo sapiens_hsa03020	2.20935107
11	Parkinsons disease_Homo sapiens_hsa05012	2.19827244
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.10967337
13	Protein export_Homo sapiens_hsa03060	2.05195631
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.92435881
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88293431
16	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.83516930
17	One carbon pool by folate_Homo sapiens_hsa00670	1.81903279
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.80358662
19	Basal transcription factors_Homo sapiens_hsa03022	1.75296381
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.67814506
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.60376049
22	RNA degradation_Homo sapiens_hsa03018	1.54585740
23	Homologous recombination_Homo sapiens_hsa03440	1.52001115
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.37547995
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34165445
26	Huntingtons disease_Homo sapiens_hsa05016	1.31214712
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.30551165
28	Alzheimers disease_Homo sapiens_hsa05010	1.29934682
29	Propanoate metabolism_Homo sapiens_hsa00640	1.28438753
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.26223246
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25362789
32	Non-homologous end-joining_Homo sapiens_hsa03450	1.24327369
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23805035
34	Phototransduction_Homo sapiens_hsa04744	1.22290848
35	Mismatch repair_Homo sapiens_hsa03430	1.17738937
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13517883
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.13258520
38	RNA transport_Homo sapiens_hsa03013	1.10490462
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.07986583
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07757095
41	Butanoate metabolism_Homo sapiens_hsa00650	1.05378000
42	Caffeine metabolism_Homo sapiens_hsa00232	1.00223507
43	Spliceosome_Homo sapiens_hsa03040	0.99708346
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.99027053
45	Purine metabolism_Homo sapiens_hsa00230	0.97750390
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.97387755
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.97367910
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97257002
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96886950
50	Sulfur metabolism_Homo sapiens_hsa00920	0.94920065
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94479295
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.91718433
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.87218955
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81805974
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80753842
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79075595
57	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78521978
58	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.78299533
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77927703
60	DNA replication_Homo sapiens_hsa03030	0.77321932
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.76687062
62	Regulation of autophagy_Homo sapiens_hsa04140	0.73135150
63	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.72806108
64	Base excision repair_Homo sapiens_hsa03410	0.72099434
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71101573
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70797882
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.69148245
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68415874
69	Viral myocarditis_Homo sapiens_hsa05416	0.66097103
70	Peroxisome_Homo sapiens_hsa04146	0.65023492
71	Sulfur relay system_Homo sapiens_hsa04122	0.64076344
72	Glutathione metabolism_Homo sapiens_hsa00480	0.63379668
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62647409
74	Retinol metabolism_Homo sapiens_hsa00830	0.61340585
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61026382
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.60766621
77	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60019545
78	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.58475162
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57162328
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51663542
81	Metabolic pathways_Homo sapiens_hsa01100	0.51529510
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50400880
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49876301
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49188910
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47728774
86	Olfactory transduction_Homo sapiens_hsa04740	0.46615471
87	Leishmaniasis_Homo sapiens_hsa05140	0.46291737
88	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.44062226
89	Folate biosynthesis_Homo sapiens_hsa00790	0.42297251
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.42121255
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41282338
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36464817
93	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.36373108
94	Herpes simplex infection_Homo sapiens_hsa05168	0.33696881
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.32813296
96	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32541012
97	Taste transduction_Homo sapiens_hsa04742	0.27676034
98	Fatty acid elongation_Homo sapiens_hsa00062	0.26329885
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.26045402
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.24547571

EEF1A1P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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