EEF1A1P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)5.63900180
2negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 5.57988291
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.43080169
4ribosomal small subunit assembly (GO:0000028)5.19976375
5water-soluble vitamin biosynthetic process (GO:0042364)4.95877027
6piRNA metabolic process (GO:0034587)4.94075125
7rRNA modification (GO:0000154)4.61059512
8positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.57104166
9cytochrome complex assembly (GO:0017004)4.49060441
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.48435071
11negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.45617749
12DNA deamination (GO:0045006)4.36390308
13regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.32283543
14pseudouridine synthesis (GO:0001522)4.28425319
15RNA localization (GO:0006403)4.25325778
16ribosomal small subunit biogenesis (GO:0042274)4.14318085
17megakaryocyte development (GO:0035855)4.12414374
18behavioral response to nicotine (GO:0035095)4.02652725
19proteasome assembly (GO:0043248)3.99103995
20regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.98345631
21positive regulation of translational initiation (GO:0045948)3.97967483
22protein complex biogenesis (GO:0070271)3.97540715
23GTP biosynthetic process (GO:0006183)3.97459687
24energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92412458
25ATP synthesis coupled proton transport (GO:0015986)3.92412458
26regulation of isotype switching to IgG isotypes (GO:0048302)3.89940425
27viral transcription (GO:0019083)3.85361874
28translational termination (GO:0006415)3.77188484
29mitochondrial respiratory chain complex assembly (GO:0033108)3.71474609
30respiratory chain complex IV assembly (GO:0008535)3.67675841
31secretory granule organization (GO:0033363)3.64645447
32signal complex assembly (GO:0007172)3.62681442
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.56608927
34cotranslational protein targeting to membrane (GO:0006613)3.51358417
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.50256852
36protein targeting to ER (GO:0045047)3.48822568
37rRNA methylation (GO:0031167)3.46497943
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45990371
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45990371
40regulation of regulatory T cell differentiation (GO:0045589)3.44674235
41regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.42327829
42regulation of immunoglobulin secretion (GO:0051023)3.37043500
43translation (GO:0006412)3.35361864
44regulation of mitochondrial translation (GO:0070129)3.34664888
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32988908
46protein localization to endoplasmic reticulum (GO:0070972)3.31809531
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31698954
48translational elongation (GO:0006414)3.27928574
49UTP biosynthetic process (GO:0006228)3.27514794
50cullin deneddylation (GO:0010388)3.27361723
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25988075
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24301962
53translational initiation (GO:0006413)3.17783906
54positive regulation of signal transduction by p53 class mediator (GO:1901798)3.16189240
55chaperone-mediated protein transport (GO:0072321)3.14307528
56negative regulation of signal transduction by p53 class mediator (GO:1901797)3.12967604
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.12321916
58termination of RNA polymerase III transcription (GO:0006386)3.12321916
59signal peptide processing (GO:0006465)3.11810398
60cellular component biogenesis (GO:0044085)3.09330791
61protein neddylation (GO:0045116)3.08377878
62regulation of chronic inflammatory response (GO:0002676)3.06683883
63peptidyl-histidine modification (GO:0018202)3.05737901
64platelet dense granule organization (GO:0060155)3.02516678
65rRNA metabolic process (GO:0016072)2.94982879
66rRNA processing (GO:0006364)2.94730476
67protein deneddylation (GO:0000338)2.94065294
68ribonucleoprotein complex biogenesis (GO:0022613)2.89448742
69response to pheromone (GO:0019236)2.86838800
70protein peptidyl-prolyl isomerization (GO:0000413)2.85995523
71DNA methylation involved in gamete generation (GO:0043046)2.84922667
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83566765
73mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83005591
74mitochondrial respiratory chain complex I assembly (GO:0032981)2.83005591
75NADH dehydrogenase complex assembly (GO:0010257)2.83005591
76cellular protein complex disassembly (GO:0043624)2.81641652
77purine nucleoside triphosphate biosynthetic process (GO:0009145)2.80177471
78purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79691154
79ribosomal large subunit biogenesis (GO:0042273)2.79268763
80positive regulation of interleukin-17 production (GO:0032740)2.79111976
81viral life cycle (GO:0019058)2.77184847
82UTP metabolic process (GO:0046051)2.76900156
83electron transport chain (GO:0022900)2.74767314
84positive regulation of isotype switching (GO:0045830)2.71880852
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.70679014
86maturation of SSU-rRNA (GO:0030490)2.70221451
87respiratory electron transport chain (GO:0022904)2.69741088
88regulation of cellular amino acid metabolic process (GO:0006521)2.65575736
89intracellular protein transmembrane import (GO:0044743)2.64249272
90regulation of meiosis I (GO:0060631)2.63217163
91negative regulation of translational initiation (GO:0045947)2.61237819
92fusion of sperm to egg plasma membrane (GO:0007342)2.60810139
93positive regulation of DNA recombination (GO:0045911)2.60801479
94male meiosis I (GO:0007141)2.59646954
95pyrimidine nucleotide catabolic process (GO:0006244)2.55309600
96production of molecular mediator involved in inflammatory response (GO:0002532)2.54743028
97CTP metabolic process (GO:0046036)2.54418032
98CTP biosynthetic process (GO:0006241)2.54418032
99ribosome biogenesis (GO:0042254)2.54415540
100RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53154527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81572014
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.25777599
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.04852665
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.91258145
5VDR_22108803_ChIP-Seq_LS180_Human3.29501289
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.01661380
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.97032629
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.78908806
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70876198
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.56477480
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54587452
12ZNF274_21170338_ChIP-Seq_K562_Hela2.52616257
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.44172700
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35288672
15VDR_23849224_ChIP-Seq_CD4+_Human2.25801696
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09994854
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06994522
18ELK1_19687146_ChIP-ChIP_HELA_Human2.03824314
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.00497013
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.95243433
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.92241928
22FOXP3_21729870_ChIP-Seq_TREG_Human1.89910837
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88121345
24EWS_26573619_Chip-Seq_HEK293_Human1.81051128
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78640518
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.69082443
27MYC_18940864_ChIP-ChIP_HL60_Human1.68570777
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67937225
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59365597
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52916181
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52027787
32GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48382048
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47382684
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43866631
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.43165767
36P300_19829295_ChIP-Seq_ESCs_Human1.43021925
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.42910845
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42910845
39SOX2_19829295_ChIP-Seq_ESCs_Human1.36362005
40NANOG_19829295_ChIP-Seq_ESCs_Human1.36362005
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33679188
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30735128
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28960094
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27250048
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23542314
46TAF15_26573619_Chip-Seq_HEK293_Human1.23216773
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22194962
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.22041259
49TTF2_22483619_ChIP-Seq_HELA_Human1.21797409
50FUS_26573619_Chip-Seq_HEK293_Human1.20921863
51TP53_22573176_ChIP-Seq_HFKS_Human1.19956054
52NCOR_22424771_ChIP-Seq_293T_Human1.17120955
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14476887
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14115357
55AR_20517297_ChIP-Seq_VCAP_Human1.12029203
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11243156
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10916509
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.10713507
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10239438
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09668683
61GATA3_26560356_Chip-Seq_TH2_Human1.08605138
62NANOG_20526341_ChIP-Seq_ESCs_Human1.08132889
63IGF1R_20145208_ChIP-Seq_DFB_Human1.06596500
64TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06447302
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05777291
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.03868323
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03779216
68RNF2_27304074_Chip-Seq_NSC_Mouse1.02907369
69DCP1A_22483619_ChIP-Seq_HELA_Human1.01984391
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01768515
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01629910
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01188030
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01135319
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01043631
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00674853
76EZH2_22144423_ChIP-Seq_EOC_Human1.00660944
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.00210089
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99951147
79TAF2_19829295_ChIP-Seq_ESCs_Human0.98467019
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98047930
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97032551
82MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96895355
83MYC_19829295_ChIP-Seq_ESCs_Human0.96818025
84ER_23166858_ChIP-Seq_MCF-7_Human0.96757520
85ERG_20517297_ChIP-Seq_VCAP_Human0.96402769
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96082741
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96064485
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95262846
89CIITA_25753668_ChIP-Seq_RAJI_Human0.94500288
90ERA_21632823_ChIP-Seq_H3396_Human0.93178366
91BCAT_22108803_ChIP-Seq_LS180_Human0.92570430
92GBX2_23144817_ChIP-Seq_PC3_Human0.92526462
93GABP_19822575_ChIP-Seq_HepG2_Human0.92132243
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.90972982
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88997464
96HOXB7_26014856_ChIP-Seq_BT474_Human0.88638070
97EGR1_19032775_ChIP-ChIP_M12_Human0.88108734
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87902903
99RBPJ_21746931_ChIP-Seq_IB4_Human0.86986600
100HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86630216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue3.68072385
2MP0002102_abnormal_ear_morphology3.27531413
3MP0000372_irregular_coat_pigmentation3.27167998
4MP0006292_abnormal_olfactory_placode3.15695870
5MP0008877_abnormal_DNA_methylation2.60100137
6MP0001835_abnormal_antigen_presentation2.58702958
7MP0008872_abnormal_physiological_respon2.35394842
8MP0002138_abnormal_hepatobiliary_system2.32958567
9MP0005646_abnormal_pituitary_gland2.12522174
10MP0005084_abnormal_gallbladder_morpholo2.09791382
11MP0009379_abnormal_foot_pigmentation2.04232123
12MP0003718_maternal_effect2.01810282
13MP0005645_abnormal_hypothalamus_physiol2.01773702
14MP0002938_white_spotting2.01223928
15MP0005671_abnormal_response_to1.92449890
16MP0001348_abnormal_lacrimal_gland1.88446789
17MP0006072_abnormal_retinal_apoptosis1.78538881
18MP0008875_abnormal_xenobiotic_pharmacok1.75354554
19MP0002876_abnormal_thyroid_physiology1.75018511
20MP0005377_hearing/vestibular/ear_phenot1.73630111
21MP0003878_abnormal_ear_physiology1.73630111
22MP0004885_abnormal_endolymph1.71516096
23MP0002148_abnormal_hypersensitivity_rea1.70555753
24MP0004145_abnormal_muscle_electrophysio1.66193280
25MP0005410_abnormal_fertilization1.61048454
26MP0005551_abnormal_eye_electrophysiolog1.61025287
27MP0002837_dystrophic_cardiac_calcinosis1.58749764
28MP0004147_increased_porphyrin_level1.55901055
29MP0003011_delayed_dark_adaptation1.55583039
30MP0002277_abnormal_respiratory_mucosa1.54567346
31MP0003787_abnormal_imprinting1.47210645
32MP0001873_stomach_inflammation1.46075442
33MP0009333_abnormal_splenocyte_physiolog1.44229124
34MP0000685_abnormal_immune_system1.42782533
35MP0003693_abnormal_embryo_hatching1.41177692
36MP0003195_calcinosis1.41147398
37MP0006036_abnormal_mitochondrial_physio1.40042291
38MP0003186_abnormal_redox_activity1.39619860
39MP0002736_abnormal_nociception_after1.37138691
40MP0005075_abnormal_melanosome_morpholog1.37053357
41MP0009764_decreased_sensitivity_to1.36842143
42MP0008789_abnormal_olfactory_epithelium1.36543878
43MP0003786_premature_aging1.36494843
44MP0005636_abnormal_mineral_homeostasis1.36404497
45MP0008058_abnormal_DNA_repair1.34908228
46MP0006035_abnormal_mitochondrial_morpho1.34493951
47MP0001790_abnormal_immune_system1.31539410
48MP0005387_immune_system_phenotype1.31539410
49MP0004742_abnormal_vestibular_system1.28819471
50MP0004142_abnormal_muscle_tone1.27081758
51MP0003283_abnormal_digestive_organ1.26369519
52MP0005253_abnormal_eye_physiology1.19967808
53MP0001968_abnormal_touch/_nociception1.18957213
54MP0005174_abnormal_tail_pigmentation1.18673845
55MP0001800_abnormal_humoral_immune1.18319463
56MP0002272_abnormal_nervous_system1.17427396
57MP0001986_abnormal_taste_sensitivity1.15075000
58MP0006276_abnormal_autonomic_nervous1.14973451
59MP0005389_reproductive_system_phenotype1.13194658
60MP0005408_hypopigmentation1.10256497
61MP0002006_tumorigenesis1.09147985
62MP0010386_abnormal_urinary_bladder1.07232100
63MP0003806_abnormal_nucleotide_metabolis1.06419600
64MP0004957_abnormal_blastocyst_morpholog1.06335523
65MP0002160_abnormal_reproductive_system1.04462725
66MP0001485_abnormal_pinna_reflex1.02100128
67MP0001984_abnormal_olfaction1.00587960
68MP0001905_abnormal_dopamine_level0.99856672
69MP0002166_altered_tumor_susceptibility0.98767759
70MP0010030_abnormal_orbit_morphology0.97534543
71MP0009785_altered_susceptibility_to0.96734466
72MP0002095_abnormal_skin_pigmentation0.96103533
73MP0001501_abnormal_sleep_pattern0.91031123
74MP0009745_abnormal_behavioral_response0.89344255
75MP0001293_anophthalmia0.89092935
76MP0009046_muscle_twitch0.87862458
77MP0001663_abnormal_digestive_system0.85998875
78MP0004133_heterotaxia0.85567437
79MP0010155_abnormal_intestine_physiology0.85510155
80MP0004019_abnormal_vitamin_homeostasis0.84932026
81MP0002210_abnormal_sex_determination0.84732470
82MP0001119_abnormal_female_reproductive0.84639208
83MP0005000_abnormal_immune_tolerance0.83934115
84MP0008775_abnormal_heart_ventricle0.83621428
85MP0004215_abnormal_myocardial_fiber0.82687615
86MP0001919_abnormal_reproductive_system0.81983532
87MP0005332_abnormal_amino_acid0.81154042
88MP0002163_abnormal_gland_morphology0.80669984
89MP0003866_abnormal_defecation0.80329010
90MP0003567_abnormal_fetal_cardiomyocyte0.79169713
91MP0003936_abnormal_reproductive_system0.78777313
92MP0002638_abnormal_pupillary_reflex0.77211985
93MP0002723_abnormal_immune_serum0.75242799
94MP0000516_abnormal_urinary_system0.73810473
95MP0005367_renal/urinary_system_phenotyp0.73810473
96MP0005394_taste/olfaction_phenotype0.72832500
97MP0005499_abnormal_olfactory_system0.72832500
98MP0002693_abnormal_pancreas_physiology0.72455968
99MP0003252_abnormal_bile_duct0.71938458
100MP0001853_heart_inflammation0.71359740

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.92631200
2Increased CSF lactate (HP:0002490)3.55231040
3Progressive macrocephaly (HP:0004481)3.47264986
4Mitochondrial inheritance (HP:0001427)3.44792022
5Acute encephalopathy (HP:0006846)3.41802801
6Increased hepatocellular lipid droplets (HP:0006565)3.38109182
7Lipid accumulation in hepatocytes (HP:0006561)3.28780168
8Stomatitis (HP:0010280)3.18001867
9Abnormal mitochondria in muscle tissue (HP:0008316)3.12253491
10Pancreatic cysts (HP:0001737)3.08454343
11Abnormality of cells of the erythroid lineage (HP:0012130)2.94271374
12Cerebral hypomyelination (HP:0006808)2.92988509
13Molar tooth sign on MRI (HP:0002419)2.87101140
14Abnormality of midbrain morphology (HP:0002418)2.87101140
15Optic disc pallor (HP:0000543)2.84060901
16Pendular nystagmus (HP:0012043)2.83406270
17Nephronophthisis (HP:0000090)2.81333383
18Reticulocytopenia (HP:0001896)2.81293675
19Renal Fanconi syndrome (HP:0001994)2.81239531
20Methylmalonic acidemia (HP:0002912)2.77149904
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.69706642
22Attenuation of retinal blood vessels (HP:0007843)2.69370362
23Abnormal number of erythroid precursors (HP:0012131)2.68987109
243-Methylglutaconic aciduria (HP:0003535)2.67165119
25Hepatocellular necrosis (HP:0001404)2.66994854
26Pancreatic fibrosis (HP:0100732)2.63133614
27Exertional dyspnea (HP:0002875)2.56202987
28Aplasia/Hypoplasia of the spleen (HP:0010451)2.55117644
29Asplenia (HP:0001746)2.53321470
30True hermaphroditism (HP:0010459)2.53155748
31Hypoproteinemia (HP:0003075)2.51302556
32Congenital, generalized hypertrichosis (HP:0004540)2.51184843
33Abnormality of the renal medulla (HP:0100957)2.46946215
34Congenital stationary night blindness (HP:0007642)2.46430416
35Abnormality of the labia minora (HP:0012880)2.43184502
36Increased serum lactate (HP:0002151)2.39993291
37Abnormality of the renal cortex (HP:0011035)2.35784811
38Cerebral edema (HP:0002181)2.35113677
39Hepatic necrosis (HP:0002605)2.34362259
40Aplastic anemia (HP:0001915)2.31295441
41Hyperglycinemia (HP:0002154)2.30519475
42Decreased central vision (HP:0007663)2.29204563
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28912738
44Macrocytic anemia (HP:0001972)2.27170257
45Agitation (HP:0000713)2.26762347
46IgG deficiency (HP:0004315)2.25032499
47Abolished electroretinogram (ERG) (HP:0000550)2.23790582
48Methylmalonic aciduria (HP:0012120)2.22943369
49Abnormality of renal resorption (HP:0011038)2.21881363
50Abnormal biliary tract physiology (HP:0012439)2.20473513
51Bile duct proliferation (HP:0001408)2.20473513
52Medial flaring of the eyebrow (HP:0010747)2.18458557
53Adrenal hypoplasia (HP:0000835)2.17391147
54Polydipsia (HP:0001959)2.17210967
55Abnormal drinking behavior (HP:0030082)2.17210967
56Abnormal rod and cone electroretinograms (HP:0008323)2.16205656
57Type 2 muscle fiber atrophy (HP:0003554)2.13600929
58Pancytopenia (HP:0001876)2.12260122
59Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12073374
60Supernumerary spleens (HP:0009799)2.11793686
61Lethargy (HP:0001254)2.09210750
62Colon cancer (HP:0003003)2.07676069
63Increased IgM level (HP:0003496)2.07495390
64Keratoconus (HP:0000563)2.04950012
65Increased corneal curvature (HP:0100692)2.04950012
66Hypoplasia of the uterus (HP:0000013)2.03289450
67Short tibia (HP:0005736)2.01041176
68Glycosuria (HP:0003076)2.00226019
69Abnormality of urine glucose concentration (HP:0011016)2.00226019
70Abnormality of alanine metabolism (HP:0010916)1.98946453
71Hyperalaninemia (HP:0003348)1.98946453
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98946453
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.94767791
74Aplasia/Hypoplasia of the fovea (HP:0008060)1.94228209
75Hypoplasia of the fovea (HP:0007750)1.94228209
76Aplasia/hypoplasia of the uterus (HP:0008684)1.91936192
77Polyuria (HP:0000103)1.90713084
78Testicular atrophy (HP:0000029)1.90049008
79Lactic acidosis (HP:0003128)1.88527825
80Sclerocornea (HP:0000647)1.87513522
81Abnormal ciliary motility (HP:0012262)1.86768654
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.86204631
83Abnormality of the phalanges of the 5th finger (HP:0004213)1.85745604
84CNS demyelination (HP:0007305)1.85397767
85Elevated erythrocyte sedimentation rate (HP:0003565)1.85108880
86Leukodystrophy (HP:0002415)1.84371557
87Hypoplasia of the ulna (HP:0003022)1.83649005
88Tubular atrophy (HP:0000092)1.83594573
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82993668
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.81255186
91Large for gestational age (HP:0001520)1.81038225
92Stenosis of the external auditory canal (HP:0000402)1.79014965
93Alveolar cell carcinoma (HP:0006519)1.78874363
94Pallor (HP:0000980)1.78783707
95Abnormality of the ileum (HP:0001549)1.78332054
96Meckel diverticulum (HP:0002245)1.78209314
97Respiratory failure (HP:0002878)1.77390566
98IgM deficiency (HP:0002850)1.77126333
99Aplasia/Hypoplasia of the ulna (HP:0006495)1.74501429
100Respiratory difficulties (HP:0002880)1.74186557

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK14.58879343
2BMPR23.55009959
3NUAK12.89240945
4TIE12.64313336
5PASK2.46740460
6TSSK62.45597044
7GRK12.45351843
8EIF2AK32.43663580
9MST42.39036452
10MAP4K12.32468704
11MAP4K22.28642640
12ADRBK22.24497223
13PRKCI2.22066013
14VRK22.19512767
15FRK2.17395895
16NEK12.04160539
17CDK191.92390037
18TLK11.90687295
19ZAK1.88055347
20STK161.78223674
21WNK41.75123180
22TRIM281.69810646
23BMPR1B1.68815636
24EIF2AK11.57826162
25BUB11.56228665
26MAP3K121.54439241
27TAOK31.53774746
28BCKDK1.52563201
29MAPKAPK31.50727523
30TXK1.47942759
31OXSR11.46353747
32NME21.32455579
33INSRR1.32250238
34WNK31.31014594
35PINK11.28385925
36DAPK31.22139943
37DYRK21.21212886
38STK38L1.17249314
39TAF11.14961629
40PRKCG1.14282687
41PLK31.14198107
42NME11.08021046
43PRKCE1.02287186
44STK391.00739212
45TGFBR11.00327384
46PBK0.97693377
47TEC0.97036665
48ACVR1B0.95047893
49ADRBK10.88470518
50PLK20.85189802
51IKBKB0.81341927
52PIK3CG0.76648800
53VRK10.75438928
54DAPK10.72731113
55TNIK0.72417783
56GRK50.68424044
57FES0.67854371
58PAK30.67639715
59KIT0.67576650
60PDK20.66247889
61FLT30.65990649
62EIF2AK20.62689956
63CSNK1G10.60495656
64PLK40.58661021
65MAP2K60.56953395
66RPS6KA50.56300882
67PRKCD0.53194680
68TGFBR20.53045636
69PTK2B0.51940127
70CSNK1G20.50339386
71MYLK0.49456000
72SRPK10.48774181
73SIK30.47777747
74PRKCQ0.47608922
75NLK0.47350916
76MAPKAPK50.44700575
77CSNK2A10.44176716
78MKNK10.43452537
79CSNK1G30.42585371
80PLK10.42520490
81PRKCZ0.42313337
82ITK0.39683484
83CSNK2A20.39496386
84CDK80.38277365
85LCK0.35255707
86KDR0.34917319
87WNK10.34764689
88GRK70.34041691
89STK30.33971505
90MARK30.33885910
91CSNK1A1L0.33459300
92PDPK10.33225883
93PHKG20.31548590
94PHKG10.31548590
95ATR0.30895301
96PRKCB0.30388988
97AURKB0.30238235
98CSK0.30044954
99CSNK1A10.28539010
100ERBB30.26744968

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.80851857
2Ribosome_Homo sapiens_hsa030103.78409140
3Proteasome_Homo sapiens_hsa030503.38426300
4Allograft rejection_Homo sapiens_hsa053303.09712766
5Autoimmune thyroid disease_Homo sapiens_hsa053202.90097682
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82171111
7Oxidative phosphorylation_Homo sapiens_hsa001902.76414770
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.65558263
9Protein export_Homo sapiens_hsa030602.61096754
10Graft-versus-host disease_Homo sapiens_hsa053322.41967568
11RNA polymerase_Homo sapiens_hsa030202.31704782
12Parkinsons disease_Homo sapiens_hsa050122.31611130
13Type I diabetes mellitus_Homo sapiens_hsa049402.21851004
14RNA degradation_Homo sapiens_hsa030182.10639169
15Phototransduction_Homo sapiens_hsa047441.99568499
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96053778
17One carbon pool by folate_Homo sapiens_hsa006701.81551439
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81122667
19Basal transcription factors_Homo sapiens_hsa030221.66842495
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56824489
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51549744
22Huntingtons disease_Homo sapiens_hsa050161.46392298
23Vitamin B6 metabolism_Homo sapiens_hsa007501.39948504
24Tyrosine metabolism_Homo sapiens_hsa003501.33713269
25RNA transport_Homo sapiens_hsa030131.32507091
26Alzheimers disease_Homo sapiens_hsa050101.29500361
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27953614
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.26345938
29Regulation of autophagy_Homo sapiens_hsa041401.24486227
30Propanoate metabolism_Homo sapiens_hsa006401.22207713
31Cardiac muscle contraction_Homo sapiens_hsa042601.21680042
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19904378
33Homologous recombination_Homo sapiens_hsa034401.19103504
34Linoleic acid metabolism_Homo sapiens_hsa005911.18860209
35Pyrimidine metabolism_Homo sapiens_hsa002401.11596197
36Antigen processing and presentation_Homo sapiens_hsa046121.09842319
37Nitrogen metabolism_Homo sapiens_hsa009101.06499336
38Rheumatoid arthritis_Homo sapiens_hsa053231.03496197
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01594621
40Purine metabolism_Homo sapiens_hsa002300.98629849
41Mismatch repair_Homo sapiens_hsa034300.96644818
42Primary immunodeficiency_Homo sapiens_hsa053400.95167785
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.92588192
44Peroxisome_Homo sapiens_hsa041460.91056793
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90689744
46Fanconi anemia pathway_Homo sapiens_hsa034600.88501813
47Sulfur relay system_Homo sapiens_hsa041220.86765569
48Caffeine metabolism_Homo sapiens_hsa002320.85217802
49Butanoate metabolism_Homo sapiens_hsa006500.84572021
50DNA replication_Homo sapiens_hsa030300.84420084
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84117571
52Tryptophan metabolism_Homo sapiens_hsa003800.83219202
53Glutathione metabolism_Homo sapiens_hsa004800.83131393
54Hematopoietic cell lineage_Homo sapiens_hsa046400.82532243
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80658419
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80103386
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79432683
58Nucleotide excision repair_Homo sapiens_hsa034200.77317465
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.73367160
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73085120
61Chemical carcinogenesis_Homo sapiens_hsa052040.69463334
62Viral myocarditis_Homo sapiens_hsa054160.66033949
63Fat digestion and absorption_Homo sapiens_hsa049750.65374097
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65054837
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64830999
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64820454
67Base excision repair_Homo sapiens_hsa034100.63707657
68T cell receptor signaling pathway_Homo sapiens_hsa046600.61511369
69Olfactory transduction_Homo sapiens_hsa047400.60875887
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59431852
71Retinol metabolism_Homo sapiens_hsa008300.56717119
72Metabolic pathways_Homo sapiens_hsa011000.54239009
73Arachidonic acid metabolism_Homo sapiens_hsa005900.54018401
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51032847
75Ether lipid metabolism_Homo sapiens_hsa005650.47319742
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46331397
77Collecting duct acid secretion_Homo sapiens_hsa049660.45786623
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45682449
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.45604462
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45484762
81Sulfur metabolism_Homo sapiens_hsa009200.42993585
82Mineral absorption_Homo sapiens_hsa049780.42594964
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.42223856
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41505828
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.41321074
86Spliceosome_Homo sapiens_hsa030400.40525771
87Folate biosynthesis_Homo sapiens_hsa007900.39467903
88Glycerolipid metabolism_Homo sapiens_hsa005610.38032740
89Epstein-Barr virus infection_Homo sapiens_hsa051690.37819005
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.33252564
91Nicotine addiction_Homo sapiens_hsa050330.33152605
92Systemic lupus erythematosus_Homo sapiens_hsa053220.31962268
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.31460511
94beta-Alanine metabolism_Homo sapiens_hsa004100.30999833
95Fatty acid degradation_Homo sapiens_hsa000710.30140606
96TGF-beta signaling pathway_Homo sapiens_hsa043500.30019500
97Pyruvate metabolism_Homo sapiens_hsa006200.28703861
98Selenocompound metabolism_Homo sapiens_hsa004500.28148149
99Fatty acid metabolism_Homo sapiens_hsa012120.28022473
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26468226

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