EEF1A1P27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle tissue regeneration (GO:0043403)9.36441476
2muscle filament sliding (GO:0030049)9.04929632
3actin-myosin filament sliding (GO:0033275)9.04929632
4negative regulation of skeletal muscle tissue development (GO:0048642)8.69574003
5regulation of skeletal muscle contraction (GO:0014819)8.39015702
6response to muscle activity (GO:0014850)7.90968495
7actin-mediated cell contraction (GO:0070252)7.31379527
8cellular response to dexamethasone stimulus (GO:0071549)6.02825634
9response to activity (GO:0014823)5.83766154
10response to dexamethasone (GO:0071548)5.55612845
11striated muscle adaptation (GO:0014888)5.16710016
12dosage compensation (GO:0007549)5.03806155
13actin filament-based movement (GO:0030048)4.87758832
14protein K6-linked ubiquitination (GO:0085020)4.87700254
15response to testosterone (GO:0033574)4.50053128
16protein trimerization (GO:0070206)4.39119200
17regulation of muscle hypertrophy (GO:0014743)4.38034725
18muscle adaptation (GO:0043500)4.25070783
19positive regulation of histone H3-K4 methylation (GO:0051571)4.20952856
20skeletal muscle contraction (GO:0003009)4.15132544
21regulation of relaxation of muscle (GO:1901077)4.13277357
22negative regulation of organelle assembly (GO:1902116)3.96440911
23cellular response to glucocorticoid stimulus (GO:0071385)3.66986032
24regulation of centriole replication (GO:0046599)3.60269280
25response to electrical stimulus (GO:0051602)3.53868951
26cellular response to corticosteroid stimulus (GO:0071384)3.44511556
27negative regulation of fatty acid biosynthetic process (GO:0045717)3.42369886
28positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.31673710
29cytidine deamination (GO:0009972)3.30837093
30cytidine metabolic process (GO:0046087)3.30837093
31cytidine catabolic process (GO:0006216)3.30837093
32positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.30765990
33tissue regeneration (GO:0042246)3.29199995
34myotube cell development (GO:0014904)3.29146428
35negative regulation of muscle tissue development (GO:1901862)3.27727073
36negative regulation of striated muscle tissue development (GO:0045843)3.25613466
37muscle organ development (GO:0007517)3.21014436
38regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.14077580
39muscle structure development (GO:0061061)3.13870878
40regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.12035240
41positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.09694556
42heparin biosynthetic process (GO:0030210)3.07348072
43heparin metabolic process (GO:0030202)3.07348072
44DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.07252262
45regulation of gene expression by genetic imprinting (GO:0006349)3.06649320
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06393944
47positive regulation of mast cell activation involved in immune response (GO:0033008)3.04561180
48positive regulation of mast cell degranulation (GO:0043306)3.04561180
49protein polyglutamylation (GO:0018095)3.01527241
50negative regulation of muscle organ development (GO:0048635)3.00716757
51DNA deamination (GO:0045006)2.99679117
52negative regulation of histone acetylation (GO:0035067)2.97147182
53muscle system process (GO:0003012)2.92088583
54cullin deneddylation (GO:0010388)2.92031643
55protein deneddylation (GO:0000338)2.83191034
56purine nucleotide salvage (GO:0032261)2.82172216
57muscle contraction (GO:0006936)2.81093205
58negative regulation of peptidyl-lysine acetylation (GO:2000757)2.77831660
59DNA damage response, signal transduction resulting in transcription (GO:0042772)2.73509146
60response to inactivity (GO:0014854)2.72288922
61cellular response to ketone (GO:1901655)2.72116636
62regulation of DNA methylation (GO:0044030)2.69536362
63regulation of histone H3-K9 methylation (GO:0051570)2.69181207
64skeletal muscle fiber development (GO:0048741)2.66050674
65alternative mRNA splicing, via spliceosome (GO:0000380)2.64143677
66positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.62404109
67pyrimidine ribonucleoside catabolic process (GO:0046133)2.61748731
68ATP synthesis coupled proton transport (GO:0015986)2.61328096
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61328096
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60652633
71negative regulation of protein acetylation (GO:1901984)2.59208249
72regulation of T cell mediated cytotoxicity (GO:0001914)2.58802153
73regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.57358972
74behavioral response to nicotine (GO:0035095)2.56386186
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55003847
76RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55003847
77regulation of hypersensitivity (GO:0002883)2.54649342
78regulation of germinal center formation (GO:0002634)2.53994973
79cellular ketone body metabolic process (GO:0046950)2.53184077
80adenosine metabolic process (GO:0046085)2.49322852
81negative regulation of histone methylation (GO:0031061)2.45957974
82sarcoplasmic reticulum calcium ion transport (GO:0070296)2.44993133
83positive regulation of mast cell activation (GO:0033005)2.44394451
84hair cycle (GO:0042633)2.42582600
85molting cycle (GO:0042303)2.42582600
86positive regulation of DNA repair (GO:0045739)2.38326668
87protein-cofactor linkage (GO:0018065)2.36449790
88regulation of sarcomere organization (GO:0060297)2.33481257
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.32086146
90preassembly of GPI anchor in ER membrane (GO:0016254)2.29825917
91response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.28244243
92postreplication repair (GO:0006301)2.27566794
93negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.26951848
94negative regulation of cell killing (GO:0031342)2.26951848
95mitochondrial calcium ion homeostasis (GO:0051560)2.25148565
96response to gravity (GO:0009629)14.3648309
97skeletal muscle adaptation (GO:0043501)12.4602271
98striated muscle atrophy (GO:0014891)12.1393524
99muscle atrophy (GO:0014889)11.1643326
100negative regulation of muscle hypertrophy (GO:0014741)10.1307573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human7.95358024
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.41396975
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.58056868
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.09593127
5TAF15_26573619_Chip-Seq_HEK293_Human3.99520255
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.08128445
7EZH2_22144423_ChIP-Seq_EOC_Human2.88866559
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80330847
9AR_21572438_ChIP-Seq_LNCaP_Human2.76037459
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72095751
11FUS_26573619_Chip-Seq_HEK293_Human2.67183514
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35126098
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32319527
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28207302
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23489546
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07504115
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.04614798
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90590852
19TP53_22573176_ChIP-Seq_HFKS_Human1.89206075
20ER_23166858_ChIP-Seq_MCF-7_Human1.80887756
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.78754335
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78377016
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74112681
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71839334
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.70727908
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55133406
27GBX2_23144817_ChIP-Seq_PC3_Human1.52918560
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49876784
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48596528
30CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.36396800
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35932235
32CEBPB_22108803_ChIP-Seq_LS180_Human1.34216881
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.33731705
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33634488
35P300_19829295_ChIP-Seq_ESCs_Human1.32557116
36ZNF274_21170338_ChIP-Seq_K562_Hela1.24100622
37KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23863098
38VDR_23849224_ChIP-Seq_CD4+_Human1.23220004
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22336362
40AR_20517297_ChIP-Seq_VCAP_Human1.19847129
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.17631625
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17250981
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16977496
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15677484
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.12998265
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09898342
47CBP_20019798_ChIP-Seq_JUKART_Human1.09898342
48KDM2B_26808549_Chip-Seq_REH_Human1.09633099
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06901220
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06701242
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06412486
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06112336
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05972603
54RXR_22108803_ChIP-Seq_LS180_Human1.05784947
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05550541
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04762081
57STAT1_20625510_ChIP-Seq_HELA_Human1.04644968
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04320784
59EWS_26573619_Chip-Seq_HEK293_Human0.99903621
60CDX2_22108803_ChIP-Seq_LS180_Human0.99510454
61MYB_26560356_Chip-Seq_TH2_Human0.98857056
62SMAD4_21799915_ChIP-Seq_A2780_Human0.98120927
63TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97102199
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96857620
65EST1_17652178_ChIP-ChIP_JURKAT_Human0.96727162
66ERG_20517297_ChIP-Seq_VCAP_Human0.95410918
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95274825
68GATA3_26560356_Chip-Seq_TH2_Human0.95104256
69RUNX_20019798_ChIP-Seq_JUKART_Human0.94690091
70SRF_21415370_ChIP-Seq_HL-1_Mouse0.94512344
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94492736
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93988489
73SOX2_19829295_ChIP-Seq_ESCs_Human0.93968179
74NANOG_19829295_ChIP-Seq_ESCs_Human0.93968179
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93773176
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93628781
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93353636
78CIITA_25753668_ChIP-Seq_RAJI_Human0.93152455
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91610817
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91595231
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.91261541
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.90889301
83MYC_19829295_ChIP-Seq_ESCs_Human0.90874569
84JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90597555
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89826708
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.89697441
87TCF4_23295773_ChIP-Seq_U87_Human0.88996959
88SALL4_22934838_ChIP-ChIP_CD34+_Human0.87248527
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86567319
90GATA3_26560356_Chip-Seq_TH1_Human0.86468500
91NCOR_22424771_ChIP-Seq_293T_Human0.85528680
92EZH2_27304074_Chip-Seq_ESCs_Mouse0.84127765
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.83883713
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83569640
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82741315
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81752966
97FOXP3_21729870_ChIP-Seq_TREG_Human0.81564150
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.80881562
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.80798401
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80163838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio5.93366641
2MP0000747_muscle_weakness5.37595437
3MP0004036_abnormal_muscle_relaxation4.27030356
4MP0002269_muscular_atrophy3.59023246
5MP0002089_abnormal_postnatal_growth/wei3.55756908
6MP0000749_muscle_degeneration3.26073944
7MP0000759_abnormal_skeletal_muscle3.00712619
8MP0003705_abnormal_hypodermis_morpholog3.00198856
9MP0005083_abnormal_biliary_tract2.70872315
10MP0002108_abnormal_muscle_morphology2.66595063
11MP0002736_abnormal_nociception_after2.61851513
12MP0001968_abnormal_touch/_nociception2.39671931
13MP0005620_abnormal_muscle_contractility2.27200235
14MP0002106_abnormal_muscle_physiology2.26074390
15MP0004087_abnormal_muscle_fiber2.23128560
16MP0004147_increased_porphyrin_level2.21051174
17MP0000566_synostosis2.04470412
18MP0003646_muscle_fatigue2.02457642
19MP0005646_abnormal_pituitary_gland1.99589937
20MP0003959_abnormal_lean_body1.97498367
21MP0003786_premature_aging1.96797873
22MP0005671_abnormal_response_to1.96328593
23MP0001835_abnormal_antigen_presentation1.87161349
24MP0002102_abnormal_ear_morphology1.83270572
25MP0005369_muscle_phenotype1.82554891
26MP0006072_abnormal_retinal_apoptosis1.78970017
27MP0002638_abnormal_pupillary_reflex1.73381321
28MP0001661_extended_life_span1.73328620
29MP0000372_irregular_coat_pigmentation1.69355657
30MP0002095_abnormal_skin_pigmentation1.63968550
31MP0003724_increased_susceptibility_to1.63425777
32MP0002876_abnormal_thyroid_physiology1.54067538
33MP0003045_fibrosis1.51217957
34MP0002837_dystrophic_cardiac_calcinosis1.48918915
35MP0005645_abnormal_hypothalamus_physiol1.42140280
36MP0005670_abnormal_white_adipose1.40525349
37MP0000427_abnormal_hair_cycle1.37010863
38MP0004885_abnormal_endolymph1.35922272
39MP0000733_abnormal_muscle_development1.35122312
40MP0004084_abnormal_cardiac_muscle1.30931711
41MP0000013_abnormal_adipose_tissue1.29782771
42MP0008995_early_reproductive_senescence1.21149098
43MP0001243_abnormal_dermal_layer1.18308525
44MP0004142_abnormal_muscle_tone1.16889933
45MP0008872_abnormal_physiological_respon1.16515598
46MP0004484_altered_response_of1.13351478
47MP0001986_abnormal_taste_sensitivity1.08301334
48MP0003787_abnormal_imprinting0.98564433
49MP0000751_myopathy0.97228041
50MP0002896_abnormal_bone_mineralization0.93667247
51MP0004130_abnormal_muscle_cell0.92308300
52MP0005167_abnormal_blood-brain_barrier0.92256547
53MP0003806_abnormal_nucleotide_metabolis0.92125129
54MP0003950_abnormal_plasma_membrane0.91181939
55MP0002723_abnormal_immune_serum0.90657139
56MP0004043_abnormal_pH_regulation0.90131688
57MP0002277_abnormal_respiratory_mucosa0.89531400
58MP0002166_altered_tumor_susceptibility0.88642799
59MP0003880_abnormal_central_pattern0.88318039
60MP0002138_abnormal_hepatobiliary_system0.88301397
61MP0008875_abnormal_xenobiotic_pharmacok0.84609086
62MP0001800_abnormal_humoral_immune0.84121993
63MP0000750_abnormal_muscle_regeneration0.83954776
64MP0001905_abnormal_dopamine_level0.83854144
65MP0001502_abnormal_circadian_rhythm0.83366532
66MP0001765_abnormal_ion_homeostasis0.82950262
67MP0008877_abnormal_DNA_methylation0.82102845
68MP0000465_gastrointestinal_hemorrhage0.80679876
69MP0005551_abnormal_eye_electrophysiolog0.79255440
70MP0009250_abnormal_appendicular_skeleto0.79061573
71MP0004215_abnormal_myocardial_fiber0.78480375
72MP0004270_analgesia0.78078211
73MP0003763_abnormal_thymus_physiology0.76651753
74MP0005000_abnormal_immune_tolerance0.75265505
75MP0003937_abnormal_limbs/digits/tail_de0.73734561
76MP0001486_abnormal_startle_reflex0.72758638
77MP0009780_abnormal_chondrocyte_physiolo0.72399619
78MP0005253_abnormal_eye_physiology0.72250982
79MP0000467_abnormal_esophagus_morphology0.72145070
80MP0000631_abnormal_neuroendocrine_gland0.71874840
81MP0000685_abnormal_immune_system0.69009699
82MP0009745_abnormal_behavioral_response0.67392877
83MP0002148_abnormal_hypersensitivity_rea0.67174816
84MP0002733_abnormal_thermal_nociception0.66809087
85MP0001501_abnormal_sleep_pattern0.66661230
86MP0002822_catalepsy0.65337747
87MP0005360_urolithiasis0.64975291
88MP0005334_abnormal_fat_pad0.64942717
89MP0002006_tumorigenesis0.64694296
90MP0005423_abnormal_somatic_nervous0.63147436
91MP0008775_abnormal_heart_ventricle0.61588965
92MP0001819_abnormal_immune_cell0.61573590
93MP0008789_abnormal_olfactory_epithelium0.61464014
94MP0002115_abnormal_skeleton_extremities0.60665358
95MP0002452_abnormal_antigen_presenting0.60118628
96MP0002396_abnormal_hematopoietic_system0.59881833
97MP0002420_abnormal_adaptive_immunity0.59070067
98MP0003866_abnormal_defecation0.59031830
99MP0000230_abnormal_systemic_arterial0.56348796
100MP0005452_abnormal_adipose_tissue0.55350578

Predicted human phenotypes

RankGene SetZ-score
1Palpebral edema (HP:0100540)8.67986561
2Distal arthrogryposis (HP:0005684)7.14940067
3Nemaline bodies (HP:0003798)7.04114952
4Round ear (HP:0100830)6.13038781
5Exercise-induced myalgia (HP:0003738)6.09304749
6Absent phalangeal crease (HP:0006109)6.04423948
7Mask-like facies (HP:0000298)5.99739457
8Muscle fiber inclusion bodies (HP:0100299)5.66049231
9Ulnar deviation of the wrist (HP:0003049)5.65344621
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.60594197
11Calcaneovalgus deformity (HP:0001848)5.22688918
12Abnormal finger flexion creases (HP:0006143)5.19901507
13Deformed tarsal bones (HP:0008119)5.00817731
14Periorbital edema (HP:0100539)4.67260689
15Hyperkalemia (HP:0002153)4.58466612
16Facial edema (HP:0000282)4.48791151
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.14781945
18Abnormality of alanine metabolism (HP:0010916)4.14781945
19Hyperalaninemia (HP:0003348)4.14781945
20Myopathic facies (HP:0002058)4.06906895
21Type 1 muscle fiber predominance (HP:0003803)3.98154729
22Myoglobinuria (HP:0002913)3.59259772
23Exercise-induced muscle cramps (HP:0003710)3.26538220
24Reduced subcutaneous adipose tissue (HP:0003758)3.15717504
25Myotonia (HP:0002486)3.11903660
26Oligomenorrhea (HP:0000876)2.93757022
27Nonprogressive disorder (HP:0003680)2.91621897
28Decreased circulating renin level (HP:0003351)2.91094224
29Abnormality of potassium homeostasis (HP:0011042)2.84563107
30Rhabdomyolysis (HP:0003201)2.78028224
31IgG deficiency (HP:0004315)2.75481182
323-Methylglutaconic aciduria (HP:0003535)2.73842813
33Neoplasm of the heart (HP:0100544)2.65495150
34Fibular aplasia (HP:0002990)2.55501238
35Elevated erythrocyte sedimentation rate (HP:0003565)2.42490780
36Constricted visual fields (HP:0001133)2.38743007
37Conical tooth (HP:0000698)2.34056115
38Abnormality of the calcaneus (HP:0008364)2.33167502
39Congenital stationary night blindness (HP:0007642)2.32263970
40Increased connective tissue (HP:0009025)2.30590924
41Abnormality of the prostate (HP:0008775)2.28283696
42Stenosis of the external auditory canal (HP:0000402)2.26792937
43Supernumerary bones of the axial skeleton (HP:0009144)2.23942962
44Maternal diabetes (HP:0009800)2.15695197
45Stomatitis (HP:0010280)2.11625835
46Metabolic acidosis (HP:0001942)2.10287143
47Mesomelia (HP:0003027)2.06658286
48Abnormality of the parietal bone (HP:0002696)2.06432632
49Abnormality of the peritoneum (HP:0002585)2.05149111
50Increased purine levels (HP:0004368)2.04094430
51Hyperuricemia (HP:0002149)2.04094430
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01616191
53Type 2 muscle fiber atrophy (HP:0003554)1.98044230
54Insulin-resistant diabetes mellitus (HP:0000831)1.96697100
55Pigmentary retinal degeneration (HP:0001146)1.95845973
56Poor speech (HP:0002465)1.94276635
57Hypokalemia (HP:0002900)1.94134373
58Toxemia of pregnancy (HP:0100603)1.93349815
59Metatarsus adductus (HP:0001840)1.92128314
60Difficulty running (HP:0009046)1.88500071
612-3 toe syndactyly (HP:0004691)1.83823674
62Abnormality of the columella (HP:0009929)1.83186451
63Malignant hyperthermia (HP:0002047)1.83105435
64Hyperphosphatemia (HP:0002905)1.82767312
65Congenital sensorineural hearing impairment (HP:0008527)1.82598102
66Supernumerary ribs (HP:0005815)1.82315680
67Muscle stiffness (HP:0003552)1.81606462
68Down-sloping shoulders (HP:0200021)1.81391822
69Abnormal rod and cone electroretinograms (HP:0008323)1.79927614
70Symphalangism affecting the phalanges of the hand (HP:0009773)1.79536790
71Hypoplastic iliac wings (HP:0002866)1.78632573
72Stomach cancer (HP:0012126)1.78374911
73Renal cortical cysts (HP:0000803)1.77385999
74Abolished electroretinogram (ERG) (HP:0000550)1.77376145
75Hypoproteinemia (HP:0003075)1.73129183
76Bell-shaped thorax (HP:0001591)1.69639695
77Tarsal synostosis (HP:0008368)1.69536968
78Decreased subcutaneous fat (HP:0001002)1.69307763
79Abnormality of chloride homeostasis (HP:0011422)1.66928909
80Abnormality of purine metabolism (HP:0004352)1.62917292
81Hyperglycemia (HP:0003074)1.62081499
82Abnormal drinking behavior (HP:0030082)1.61905837
83Polydipsia (HP:0001959)1.61905837
84Abnormality of the phalanges of the 2nd finger (HP:0009541)1.59097886
85Congenital, generalized hypertrichosis (HP:0004540)1.59094431
86Fatigue (HP:0012378)1.58565986
87Paralysis (HP:0003470)1.57244458
88Cerebral palsy (HP:0100021)1.56500387
89Abnormality of macular pigmentation (HP:0008002)1.55104544
90Pulmonary embolism (HP:0002204)1.54111487
91Synostosis involving bones of the lower limbs (HP:0009138)1.53222778
92Synostosis involving bones of the feet (HP:0009140)1.53222778
93Hypoalphalipoproteinemia (HP:0003233)1.52978744
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.49411062
95Attenuation of retinal blood vessels (HP:0007843)1.49211195
96Prostate neoplasm (HP:0100787)1.48337761
97Muscle fiber atrophy (HP:0100295)1.48101524
98Generalized aminoaciduria (HP:0002909)1.47693276
99Short phalanx of the thumb (HP:0009660)1.47153802
100Abnormality of the renal cortex (HP:0011035)1.46236559

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG24.38614667
2PHKG14.38614667
3TIE14.16650003
4OBSCN3.67141008
5TXK2.96782525
6TLK12.92283606
7MAP4K22.86866643
8JAK32.57544436
9WNK42.44656772
10SCYL22.42828583
11MAP3K122.39839490
12NUAK12.31113746
13WNK11.81967963
14TAOK31.77218936
15ADRBK21.66140274
16PIK3CA1.63826591
17CAMKK21.60302769
18BCKDK1.51969863
19IRAK11.49642642
20ZAK1.46394383
21MAPK131.42176540
22TYRO31.41339911
23MAP4K11.40495295
24BMPR21.39030861
25TEC1.38196059
26PINK11.31650993
27FES1.29799129
28MAP2K21.28674814
29MUSK1.22473229
30CCNB11.19468802
31TESK21.13446078
32TRPM71.12422387
33GRK61.10961600
34PIK3CG1.09141296
35STK161.07352465
36LIMK11.05317422
37MAP3K141.02728651
38GRK11.01361931
39MYLK1.00915283
40ITK0.98650869
41CHEK20.94315024
42CDK40.94155396
43FRK0.93304992
44EIF2AK20.92337509
45OXSR10.90883254
46CAMK2G0.90385512
47KIT0.90128844
48CAMK1D0.89637097
49FGFR20.83777775
50CSNK1G20.82260990
51MST40.78235685
52CSF1R0.76203880
53DAPK20.75112078
54IKBKB0.72666439
55MAPK70.71419926
56CSNK1G10.71259557
57EIF2AK30.71197900
58SYK0.69204939
59AURKA0.68253502
60ILK0.68108975
61CASK0.67061250
62STK390.66860738
63PDK20.65216902
64CSNK1A1L0.64995174
65INSRR0.64359779
66CSNK1G30.61467420
67PRKG10.57681827
68DYRK20.55911530
69DAPK10.55716749
70MAPKAPK30.52627287
71FGFR30.51634505
72MARK30.50138945
73BTK0.48013063
74RPS6KA50.47484935
75PIM10.45270945
76PRKCE0.44459951
77SGK10.40024887
78LCK0.39901968
79MAPK120.39691645
80IGF1R0.39503314
81PRKCQ0.39455250
82DYRK1B0.38451590
83MAP2K30.37708963
84IKBKE0.37175639
85CAMK10.34994417
86ADRBK10.33207536
87CDK190.32753772
88VRK20.32498075
89SGK20.32348919
90SGK2230.32176143
91SGK4940.32176143
92ERBB30.31878124
93CAMK1G0.31473815
94EPHA30.30861378
95LYN0.30738362
96KDR0.29235628
97FLT30.29070792
98CAMKK10.28978915
99ABL10.28862301
100PAK60.28184250

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.05878782
2Allograft rejection_Homo sapiens_hsa053303.66320926
3Autoimmune thyroid disease_Homo sapiens_hsa053203.49344180
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.38491512
5Graft-versus-host disease_Homo sapiens_hsa053323.25111160
6Regulation of autophagy_Homo sapiens_hsa041403.07962253
7Tight junction_Homo sapiens_hsa045302.66008657
8Type I diabetes mellitus_Homo sapiens_hsa049402.63746544
9Proteasome_Homo sapiens_hsa030502.53001261
10Nitrogen metabolism_Homo sapiens_hsa009102.48071883
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35890871
12Antigen processing and presentation_Homo sapiens_hsa046122.31408488
13Ribosome_Homo sapiens_hsa030102.05463313
14Viral myocarditis_Homo sapiens_hsa054161.72170100
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61084118
16Primary immunodeficiency_Homo sapiens_hsa053401.59743593
17Rheumatoid arthritis_Homo sapiens_hsa053231.57975682
18Oxidative phosphorylation_Homo sapiens_hsa001901.57557443
19Cardiac muscle contraction_Homo sapiens_hsa042601.41137574
20Oxytocin signaling pathway_Homo sapiens_hsa049211.36626026
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33488516
22Morphine addiction_Homo sapiens_hsa050321.30131055
23RNA degradation_Homo sapiens_hsa030181.29634259
24Circadian entrainment_Homo sapiens_hsa047131.25364675
25Arginine biosynthesis_Homo sapiens_hsa002201.21290089
26Systemic lupus erythematosus_Homo sapiens_hsa053221.21098282
27Circadian rhythm_Homo sapiens_hsa047101.19595905
28Protein export_Homo sapiens_hsa030601.19309278
29Parkinsons disease_Homo sapiens_hsa050121.18783533
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13904996
31Renin secretion_Homo sapiens_hsa049241.05539917
32Calcium signaling pathway_Homo sapiens_hsa040201.05478137
33Leishmaniasis_Homo sapiens_hsa051401.01292205
34GABAergic synapse_Homo sapiens_hsa047271.00284445
35Alzheimers disease_Homo sapiens_hsa050101.00185639
36Maturity onset diabetes of the young_Homo sapiens_hsa049500.98730688
37T cell receptor signaling pathway_Homo sapiens_hsa046600.94603012
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93456507
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93326032
40Olfactory transduction_Homo sapiens_hsa047400.93076498
41Spliceosome_Homo sapiens_hsa030400.92091226
42Phototransduction_Homo sapiens_hsa047440.90483934
43Gastric acid secretion_Homo sapiens_hsa049710.90318084
44One carbon pool by folate_Homo sapiens_hsa006700.85745744
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83839514
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79833355
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79546679
48Serotonergic synapse_Homo sapiens_hsa047260.78719480
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.76988470
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76436780
51Insulin secretion_Homo sapiens_hsa049110.73051407
52Chemical carcinogenesis_Homo sapiens_hsa052040.70809048
53Nicotine addiction_Homo sapiens_hsa050330.69493878
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69450636
55Fanconi anemia pathway_Homo sapiens_hsa034600.69188564
56Salivary secretion_Homo sapiens_hsa049700.68405196
57Linoleic acid metabolism_Homo sapiens_hsa005910.66791393
58Dopaminergic synapse_Homo sapiens_hsa047280.66556590
59Staphylococcus aureus infection_Homo sapiens_hsa051500.64755107
60Taste transduction_Homo sapiens_hsa047420.64229889
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60804468
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59708558
63Basal transcription factors_Homo sapiens_hsa030220.57981460
64Hematopoietic cell lineage_Homo sapiens_hsa046400.56336510
65Cholinergic synapse_Homo sapiens_hsa047250.54884615
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.54008858
67Caffeine metabolism_Homo sapiens_hsa002320.53462846
68RNA polymerase_Homo sapiens_hsa030200.53384171
69Glucagon signaling pathway_Homo sapiens_hsa049220.53349758
70Huntingtons disease_Homo sapiens_hsa050160.52191297
71Herpes simplex infection_Homo sapiens_hsa051680.51378245
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50345653
73Platelet activation_Homo sapiens_hsa046110.48867799
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47153713
75Epstein-Barr virus infection_Homo sapiens_hsa051690.46830646
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46030103
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45664933
78Pancreatic secretion_Homo sapiens_hsa049720.45639419
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45121678
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44499051
81Amphetamine addiction_Homo sapiens_hsa050310.43713919
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43377740
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42141824
84Collecting duct acid secretion_Homo sapiens_hsa049660.41314334
85Tryptophan metabolism_Homo sapiens_hsa003800.37758552
86Purine metabolism_Homo sapiens_hsa002300.36864664
87RNA transport_Homo sapiens_hsa030130.35015017
88Dilated cardiomyopathy_Homo sapiens_hsa054140.34820586
89Ether lipid metabolism_Homo sapiens_hsa005650.34210219
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34180079
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30249594
92Wnt signaling pathway_Homo sapiens_hsa043100.29136240
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28572534
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27301306
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26915567
96Arachidonic acid metabolism_Homo sapiens_hsa005900.26216968
97Measles_Homo sapiens_hsa051620.25709910
98Toxoplasmosis_Homo sapiens_hsa051450.23952071
99Homologous recombination_Homo sapiens_hsa034400.23535265
100Oocyte meiosis_Homo sapiens_hsa041140.23529233

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