ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.35517144
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.39689482
3	proteasome assembly (GO:0043248)	4.17266654
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.16581196
5	ATP synthesis coupled proton transport (GO:0015986)	4.16581196
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.95544061
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.83874861
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.80010440
9	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.80010440
10	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.72189305
11	rRNA modification (GO:0000154)	3.67119927
12	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.66559443
13	protein neddylation (GO:0045116)	3.63624730
14	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.61725198
15	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.60141975
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.56039747
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.51688652
18	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.39083531
19	piRNA metabolic process (GO:0034587)	3.34025709
20	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.29257589
21	ribosomal small subunit assembly (GO:0000028)	3.28664722
22	regulation of cellular amino acid metabolic process (GO:0006521)	3.26859442
23	positive regulation of interleukin-17 production (GO:0032740)	3.22229158
24	chaperone-mediated protein transport (GO:0072321)	3.21287289
25	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.17315808
26	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.17315808
27	isotype switching (GO:0045190)	3.17315808
28	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.16581436
29	positive regulation of defense response to virus by host (GO:0002230)	3.15980720
30	regulation of isotype switching to IgG isotypes (GO:0048302)	3.14900283
31	cullin deneddylation (GO:0010388)	3.13841492
32	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.12949640
33	fucose catabolic process (GO:0019317)	3.12780689
34	L-fucose metabolic process (GO:0042354)	3.12780689
35	L-fucose catabolic process (GO:0042355)	3.12780689
36	termination of RNA polymerase III transcription (GO:0006386)	3.11265418
37	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.11265418
38	rRNA methylation (GO:0031167)	3.11168243
39	preassembly of GPI anchor in ER membrane (GO:0016254)	3.11000404
40	regulation of immunoglobulin secretion (GO:0051023)	3.09678698
41	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.07746603
42	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.07746603
43	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.07746603
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.04265384
45	pseudouridine synthesis (GO:0001522)	3.04139126
46	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.01878733
47	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.01878733
48	protein deneddylation (GO:0000338)	3.00774473
49	protein complex biogenesis (GO:0070271)	2.98016995
50	respiratory chain complex IV assembly (GO:0008535)	2.96860764
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.96274075
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.96274075
53	NADH dehydrogenase complex assembly (GO:0010257)	2.96274075
54	regulation of regulatory T cell differentiation (GO:0045589)	2.95679529
55	positive regulation of prostaglandin secretion (GO:0032308)	2.94940709
56	mannosylation (GO:0097502)	2.93517342
57	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.91871527
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.91811569
59	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.91421623
60	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.91421623
61	GTP biosynthetic process (GO:0006183)	2.90787701
62	tRNA processing (GO:0008033)	2.87672994
63	peptidyl-histidine modification (GO:0018202)	2.87080419
64	regulation of memory T cell differentiation (GO:0043380)	2.86806571
65	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.86140225
66	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83568963
67	negative regulation of ligase activity (GO:0051352)	2.81372789
68	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.81372789
69	cytidine metabolic process (GO:0046087)	2.81343689
70	cytidine catabolic process (GO:0006216)	2.81343689
71	cytidine deamination (GO:0009972)	2.81343689
72	behavioral response to nicotine (GO:0035095)	2.79759707
73	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.78449178
74	ribosomal large subunit biogenesis (GO:0042273)	2.77799673
75	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.76643035
76	platelet dense granule organization (GO:0060155)	2.72015255
77	positive regulation of T-helper 1 type immune response (GO:0002827)	2.69542352
78	tRNA metabolic process (GO:0006399)	2.65699634
79	maturation of 5.8S rRNA (GO:0000460)	2.65690607
80	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.62974629
81	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.60559830
82	electron transport chain (GO:0022900)	2.60532740
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.60443461
84	protein-cofactor linkage (GO:0018065)	2.59958663
85	regulation of T cell mediated cytotoxicity (GO:0001914)	2.58305613
86	respiratory electron transport chain (GO:0022904)	2.57399084
87	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.54603386
88	L-methionine salvage (GO:0071267)	2.54161652
89	L-methionine biosynthetic process (GO:0071265)	2.54161652
90	amino acid salvage (GO:0043102)	2.54161652
91	aldehyde catabolic process (GO:0046185)	2.53878935
92	rRNA processing (GO:0006364)	2.52561105
93	cytochrome complex assembly (GO:0017004)	2.52361406
94	rRNA metabolic process (GO:0016072)	2.51408258
95	tRNA modification (GO:0006400)	2.51321225
96	intracellular protein transmembrane import (GO:0044743)	2.50918347
97	DNA methylation involved in gamete generation (GO:0043046)	2.49487259
98	regulation of mitotic spindle checkpoint (GO:1903504)	2.49154767
99	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.49154767
100	somatic diversification of immunoglobulins (GO:0016445)	2.48943400

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.63834446
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.22028809
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.74625383
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.71009474
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.02822208
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.01914035
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.97582713
8	VDR_23849224_ChIP-Seq_CD4+_Human	2.92488989
9	VDR_22108803_ChIP-Seq_LS180_Human	2.86573745
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.86161916
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.72340261
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.63209813
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.56714358
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.36965045
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.34886024
16	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.32871747
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32338919
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.28543887
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24395653
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.16464591
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.05069870
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.04400396
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.02951197
24	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.01319100
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.92335416
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.84296139
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.81828052
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.80820520
29	EWS_26573619_Chip-Seq_HEK293_Human	1.80646606
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70021422
31	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67351237
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.62254293
33	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.61962765
34	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.59790358
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.58269952
36	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.53010610
37	GATA3_26560356_Chip-Seq_TH2_Human	1.52391503
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.47815618
39	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.46582386
40	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45760532
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39805502
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.38360125
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37688370
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37056036
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37056036
46	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.35919098
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.33807993
48	FUS_26573619_Chip-Seq_HEK293_Human	1.33308650
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.32632871
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31386840
51	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.30012920
52	TTF2_22483619_ChIP-Seq_HELA_Human	1.29018722
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28901459
54	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28586202
55	DCP1A_22483619_ChIP-Seq_HELA_Human	1.26508624
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26112578
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25755205
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24641226
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24641226
60	AR_20517297_ChIP-Seq_VCAP_Human	1.24531371
61	GABP_19822575_ChIP-Seq_HepG2_Human	1.23534645
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22999123
63	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.20150503
64	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.19720733
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.19183602
66	TAF15_26573619_Chip-Seq_HEK293_Human	1.17649826
67	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15148070
68	P300_19829295_ChIP-Seq_ESCs_Human	1.15146481
69	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.12938622
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.11260310
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11218203
72	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.10376624
73	ER_23166858_ChIP-Seq_MCF-7_Human	1.10240397
74	MYB_26560356_Chip-Seq_TH2_Human	1.08794960
75	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.06535103
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05514729
77	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05502482
78	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04586751
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01677175
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.00128383
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99892838
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99601691
83	NCOR_22424771_ChIP-Seq_293T_Human	0.98494372
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98316125
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.97468462
86	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97337680
87	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.95963228
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94923771
89	CBP_20019798_ChIP-Seq_JUKART_Human	0.94923771
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94161356
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93765054
92	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.92976994
93	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92708010
94	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.91461063
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89318578
96	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.88856268
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87935565
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87814230
99	ERG_20517297_ChIP-Seq_VCAP_Human	0.87076856
100	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.86805198

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	3.66910164
2	MP0005671_abnormal_response_to	3.21970693
3	MP0002138_abnormal_hepatobiliary_system	2.91112087
4	MP0008877_abnormal_DNA_methylation	2.87745226
5	MP0002102_abnormal_ear_morphology	2.54379459
6	MP0005084_abnormal_gallbladder_morpholo	2.54129372
7	MP0008875_abnormal_xenobiotic_pharmacok	2.39018679
8	MP0006072_abnormal_retinal_apoptosis	2.30309281
9	MP0004147_increased_porphyrin_level	2.27860594
10	MP0003195_calcinosis	2.26221078
11	MP0005075_abnormal_melanosome_morpholog	2.25073367
12	MP0008872_abnormal_physiological_respon	2.22519258
13	MP0008058_abnormal_DNA_repair	2.21001461
14	MP0002148_abnormal_hypersensitivity_rea	2.15514139
15	MP0000372_irregular_coat_pigmentation	2.13350810
16	MP0000685_abnormal_immune_system	2.11244417
17	MP0003806_abnormal_nucleotide_metabolis	2.06121103
18	MP0006292_abnormal_olfactory_placode	2.01198219
19	MP0001790_abnormal_immune_system	2.00643280
20	MP0005387_immune_system_phenotype	2.00643280
21	MP0001800_abnormal_humoral_immune	1.96040100
22	MP0009785_altered_susceptibility_to	1.95880657
23	MP0003786_premature_aging	1.93999079
24	MP0002166_altered_tumor_susceptibility	1.86015973
25	MP0005000_abnormal_immune_tolerance	1.83951045
26	MP0001986_abnormal_taste_sensitivity	1.80958647
27	MP0001873_stomach_inflammation	1.73989908
28	MP0002006_tumorigenesis	1.68528061
29	MP0001968_abnormal_touch/_nociception	1.65300386
30	MP0003718_maternal_effect	1.63791568
31	MP0003724_increased_susceptibility_to	1.61132616
32	MP0002736_abnormal_nociception_after	1.57644708
33	MP0002723_abnormal_immune_serum	1.54386860
34	MP0009333_abnormal_splenocyte_physiolog	1.53862766
35	MP0009764_decreased_sensitivity_to	1.48645546
36	MP0002452_abnormal_antigen_presenting	1.43296163
37	MP0002876_abnormal_thyroid_physiology	1.41912703
38	MP0008007_abnormal_cellular_replicative	1.38159267
39	MP0003646_muscle_fatigue	1.34317734
40	MP0002420_abnormal_adaptive_immunity	1.32676861
41	MP0005551_abnormal_eye_electrophysiolog	1.32643940
42	MP0001819_abnormal_immune_cell	1.31640053
43	MP0004885_abnormal_endolymph	1.28477617
44	MP0003763_abnormal_thymus_physiology	1.28220434
45	MP0005645_abnormal_hypothalamus_physiol	1.26750220
46	MP0006036_abnormal_mitochondrial_physio	1.26608609
47	MP0010094_abnormal_chromosome_stability	1.22763326
48	MP0005646_abnormal_pituitary_gland	1.20002197
49	MP0008775_abnormal_heart_ventricle	1.18084541
50	MP0001501_abnormal_sleep_pattern	1.17030148
51	MP0004142_abnormal_muscle_tone	1.16752607
52	MP0003866_abnormal_defecation	1.15368322
53	MP0003186_abnormal_redox_activity	1.14475791
54	MP0005253_abnormal_eye_physiology	1.13721664
55	MP0004145_abnormal_muscle_electrophysio	1.12484385
56	MP0003567_abnormal_fetal_cardiomyocyte	1.11847807
57	MP0010155_abnormal_intestine_physiology	1.11707594
58	MP0003693_abnormal_embryo_hatching	1.08489414
59	MP0000689_abnormal_spleen_morphology	1.06889150
60	MP0005389_reproductive_system_phenotype	1.06690143
61	MP0001919_abnormal_reproductive_system	1.05647807
62	MP0003252_abnormal_bile_duct	1.03186841
63	MP0001845_abnormal_inflammatory_respons	1.02282634
64	MP0002938_white_spotting	1.02123655
65	MP0001764_abnormal_homeostasis	1.01849145
66	MP0002398_abnormal_bone_marrow	0.98863798
67	MP0003436_decreased_susceptibility_to	0.98593283
68	MP0001293_anophthalmia	0.98498095
69	MP0006035_abnormal_mitochondrial_morpho	0.96562813
70	MP0002405_respiratory_system_inflammati	0.93646143
71	MP0000716_abnormal_immune_system	0.92145723
72	MP0002933_joint_inflammation	0.91023334
73	MP0002163_abnormal_gland_morphology	0.89755072
74	MP0005636_abnormal_mineral_homeostasis	0.89287871
75	MP0002837_dystrophic_cardiac_calcinosis	0.89243720
76	MP0003787_abnormal_imprinting	0.88528772
77	MP0005332_abnormal_amino_acid	0.88098591
78	MP0005025_abnormal_response_to	0.85541740
79	MP0008469_abnormal_protein_level	0.81642454
80	MP0001905_abnormal_dopamine_level	0.80322263
81	MP0002429_abnormal_blood_cell	0.79560870
82	MP0000465_gastrointestinal_hemorrhage	0.78480581
83	MP0002234_abnormal_pharynx_morphology	0.78413818
84	MP0000427_abnormal_hair_cycle	0.78375442
85	MP0002722_abnormal_immune_system	0.76991231
86	MP0000703_abnormal_thymus_morphology	0.76627175
87	MP0004957_abnormal_blastocyst_morpholog	0.76267472
88	MP0002277_abnormal_respiratory_mucosa	0.75794779
89	MP0000569_abnormal_digit_pigmentation	0.75261751
90	MP0005167_abnormal_blood-brain_barrier	0.75183866
91	MP0002272_abnormal_nervous_system	0.74541173
92	MP0002693_abnormal_pancreas_physiology	0.73172469
93	MP0005410_abnormal_fertilization	0.73040384
94	MP0002928_abnormal_bile_duct	0.72576846
95	MP0004043_abnormal_pH_regulation	0.71214859
96	MP0005365_abnormal_bile_salt	0.69053490
97	MP0002019_abnormal_tumor_incidence	0.68193563
98	MP0005085_abnormal_gallbladder_physiolo	0.67590519
99	MP0008995_early_reproductive_senescence	0.66975187
100	MP0001929_abnormal_gametogenesis	0.66929338

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	3.84773193
2	Stomatitis (HP:0010280)	3.71152703
3	Acute necrotizing encephalopathy (HP:0006965)	3.57282704
4	3-Methylglutaconic aciduria (HP:0003535)	3.35297629
5	Acute encephalopathy (HP:0006846)	3.32363744
6	Increased CSF lactate (HP:0002490)	3.29480939
7	Pancreatic cysts (HP:0001737)	3.29050555
8	Mitochondrial inheritance (HP:0001427)	3.25898083
9	Progressive macrocephaly (HP:0004481)	3.09454380
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.02617547
11	Abolished electroretinogram (ERG) (HP:0000550)	2.95097999
12	Congenital, generalized hypertrichosis (HP:0004540)	2.93715849
13	Type II lissencephaly (HP:0007260)	2.91413489
14	Lipid accumulation in hepatocytes (HP:0006561)	2.89952510
15	Increased hepatocellular lipid droplets (HP:0006565)	2.89200580
16	Hepatocellular necrosis (HP:0001404)	2.81223939
17	Methylmalonic acidemia (HP:0002912)	2.74152511
18	Abnormality of alanine metabolism (HP:0010916)	2.72674358
19	Hyperalaninemia (HP:0003348)	2.72674358
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.72674358
21	Nephronophthisis (HP:0000090)	2.70676064
22	Congenital stationary night blindness (HP:0007642)	2.70230951
23	Hepatic necrosis (HP:0002605)	2.65427076
24	Increased IgM level (HP:0003496)	2.63557625
25	Increased serum lactate (HP:0002151)	2.63467681
26	Elevated erythrocyte sedimentation rate (HP:0003565)	2.62686213
27	Pancreatic fibrosis (HP:0100732)	2.61418555
28	Molar tooth sign on MRI (HP:0002419)	2.60126834
29	Abnormality of midbrain morphology (HP:0002418)	2.60126834
30	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.57225652
31	Abnormality of the renal cortex (HP:0011035)	2.54258749
32	Hypoproteinemia (HP:0003075)	2.48461700
33	Methylmalonic aciduria (HP:0012120)	2.47749953
34	Cerebral edema (HP:0002181)	2.45199874
35	Abnormality of B cell number (HP:0010975)	2.44734042
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.43005480
37	Aplasia/hypoplasia of the uterus (HP:0008684)	2.40471023
38	True hermaphroditism (HP:0010459)	2.39155168
39	Abnormality of the pons (HP:0007361)	2.39079787
40	Renal cortical cysts (HP:0000803)	2.38530893
41	Optic disc pallor (HP:0000543)	2.36708373
42	Abnormality of the prostate (HP:0008775)	2.35360867
43	Abnormality of T cell physiology (HP:0011840)	2.33049729
44	Severe combined immunodeficiency (HP:0004430)	2.32949163
45	Type 2 muscle fiber atrophy (HP:0003554)	2.30595711
46	Lactic acidosis (HP:0003128)	2.30167286
47	Abnormality of the renal medulla (HP:0100957)	2.29382687
48	Renal Fanconi syndrome (HP:0001994)	2.26331690
49	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.23455865
50	Abnormality of T cells (HP:0002843)	2.21951294
51	B lymphocytopenia (HP:0010976)	2.19924258
52	Pancytopenia (HP:0001876)	2.19488156
53	Pendular nystagmus (HP:0012043)	2.15679246
54	Hyperglycinemia (HP:0002154)	2.15403853
55	Delayed CNS myelination (HP:0002188)	2.14029221
56	Hypoplasia of the pons (HP:0012110)	2.13750138
57	Attenuation of retinal blood vessels (HP:0007843)	2.13126937
58	Optic neuritis (HP:0100653)	2.12243655
59	Retrobulbar optic neuritis (HP:0100654)	2.12243655
60	Bile duct proliferation (HP:0001408)	2.12015884
61	Abnormal biliary tract physiology (HP:0012439)	2.12015884
62	Exertional dyspnea (HP:0002875)	2.11827534
63	Type I transferrin isoform profile (HP:0003642)	2.11059969
64	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10322818
65	Lethargy (HP:0001254)	2.09727013
66	Abnormality of serum amino acid levels (HP:0003112)	2.06657066
67	Panhypogammaglobulinemia (HP:0003139)	2.04838191
68	Abnormal rod and cone electroretinograms (HP:0008323)	2.01156019
69	Abnormality of T cell number (HP:0011839)	1.98832117
70	Thyroiditis (HP:0100646)	1.98489263
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.98263866
72	Testicular atrophy (HP:0000029)	1.98077339
73	Constricted visual fields (HP:0001133)	1.97476068
74	Hypothermia (HP:0002045)	1.93683242
75	Increased intramyocellular lipid droplets (HP:0012240)	1.93369279
76	Hypoplasia of the uterus (HP:0000013)	1.92318528
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.92025868
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.92025868
79	Abnormal protein glycosylation (HP:0012346)	1.92025868
80	Abnormal glycosylation (HP:0012345)	1.92025868
81	Hyperglycinuria (HP:0003108)	1.91983664
82	Abnormality of the ileum (HP:0001549)	1.88934077
83	Dyschromatopsia (HP:0007641)	1.88404243
84	Abnormality of glycine metabolism (HP:0010895)	1.88148015
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.88148015
86	T lymphocytopenia (HP:0005403)	1.87559929
87	Abnormal number of erythroid precursors (HP:0012131)	1.86334633
88	Meckel diverticulum (HP:0002245)	1.84129742
89	Chronic diarrhea (HP:0002028)	1.83633692
90	Decreased central vision (HP:0007663)	1.83017626
91	Muscle fiber atrophy (HP:0100295)	1.82881068
92	Aplastic anemia (HP:0001915)	1.80889528
93	Hypomagnesemia (HP:0002917)	1.80183026
94	Colon cancer (HP:0003003)	1.80126657
95	IgM deficiency (HP:0002850)	1.79624763
96	Prostate neoplasm (HP:0100787)	1.79452129
97	Medial flaring of the eyebrow (HP:0010747)	1.79424098
98	Abnormality of methionine metabolism (HP:0010901)	1.78692653
99	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76663991
100	Abnormal drinking behavior (HP:0030082)	1.76002063

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.33721753
2	TLK1	3.31786826
3	ZAK	3.31150839
4	TXK	3.09517270
5	NUAK1	2.90605708
6	TSSK6	2.72036949
7	MAP4K2	2.37780882
8	VRK2	2.35995606
9	ADRBK2	2.35758696
10	TIE1	2.25987925
11	GRK1	2.20223195
12	EIF2AK3	2.18536539
13	MST4	2.15625533
14	BUB1	2.12304952
15	FRK	2.03611824
16	VRK1	1.91775967
17	WNK4	1.83666720
18	STK16	1.71069254
19	BMPR1B	1.62227321
20	OXSR1	1.55180801
21	TEC	1.52277626
22	SRPK1	1.49135785
23	BCKDK	1.45659599
24	PASK	1.44654220
25	STK39	1.43074732
26	FES	1.42892815
27	PLK3	1.40506634
28	NEK1	1.39881421
29	IKBKB	1.39324642
30	MAP3K14	1.36149483
31	PINK1	1.35588005
32	MKNK1	1.32856773
33	WNK3	1.29339080
34	MAP3K12	1.26004611
35	KIT	1.20423042
36	TAF1	1.19938089
37	ITK	1.16604070
38	BMPR2	1.16529562
39	EIF2AK1	1.14869736
40	NME1	1.11836970
41	TRIM28	1.11410006
42	MAP4K1	1.09488211
43	ACVR1B	1.08794656
44	EIF2AK2	1.02265908
45	CDK19	1.01255834
46	ERBB3	0.97987699
47	MAP2K6	0.95841784
48	PDK2	0.95831741
49	PHKG2	0.91072220
50	PHKG1	0.91072220
51	MKNK2	0.85258604
52	FLT3	0.84160608
53	MAPKAPK3	0.81137346
54	TGFBR1	0.80558964
55	DYRK2	0.79059271
56	RPS6KA5	0.78851030
57	IKBKE	0.76370638
58	SYK	0.75860300
59	PLK4	0.73501089
60	PRKCQ	0.72759576
61	INSRR	0.70500762
62	KDR	0.65889668
63	ALK	0.64090192
64	DAPK1	0.63830569
65	PLK2	0.63775417
66	MAPKAPK5	0.62873552
67	CAMKK2	0.61125943
68	GRK6	0.59433374
69	LCK	0.58864264
70	BTK	0.57357944
71	PBK	0.55838246
72	LYN	0.54953549
73	CHUK	0.51740063
74	PLK1	0.51577400
75	MYLK	0.49746807
76	NLK	0.49746693
77	ADRBK1	0.49624101
78	CSF1R	0.48145489
79	ATR	0.47941794
80	PRKCE	0.46484423
81	IGF1R	0.45802927
82	BRSK2	0.45636748
83	SIK3	0.44370962
84	CSNK1G1	0.44244453
85	TNIK	0.43409225
86	CDC7	0.42738711
87	CSNK1G3	0.42507542
88	SCYL2	0.41883726
89	AURKB	0.41438613
90	JAK3	0.36996966
91	TNK2	0.35140375
92	CSNK2A1	0.35118525
93	CSNK2A2	0.33859248
94	CSNK1G2	0.33796705
95	GRK5	0.33754516
96	MUSK	0.32884669
97	TRPM7	0.31270385
98	MAP2K2	0.29804505
99	CSNK1A1	0.28826551
100	HCK	0.27724071

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.94957405
2	Asthma_Homo sapiens_hsa05310	3.75305187
3	Allograft rejection_Homo sapiens_hsa05330	3.18621566
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.05512112
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.99008611
6	Graft-versus-host disease_Homo sapiens_hsa05332	2.57956401
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.44108505
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.43617440
9	RNA polymerase_Homo sapiens_hsa03020	2.37211935
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.35012867
11	Ribosome_Homo sapiens_hsa03010	2.34370431
12	Protein export_Homo sapiens_hsa03060	2.29640625
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.12173654
14	Parkinsons disease_Homo sapiens_hsa05012	2.00859990
15	One carbon pool by folate_Homo sapiens_hsa00670	2.00083962
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.99504650
17	Homologous recombination_Homo sapiens_hsa03440	1.88007613
18	RNA degradation_Homo sapiens_hsa03018	1.73570006
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68411938
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.54629495
21	Propanoate metabolism_Homo sapiens_hsa00640	1.54158357
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.53866555
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.49852318
24	Basal transcription factors_Homo sapiens_hsa03022	1.41171992
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.39182868
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.35522822
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.34655677
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34472438
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.34211563
30	Phototransduction_Homo sapiens_hsa04744	1.27552300
31	Caffeine metabolism_Homo sapiens_hsa00232	1.24778177
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23987798
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.22589780
34	Huntingtons disease_Homo sapiens_hsa05016	1.19774289
35	Mismatch repair_Homo sapiens_hsa03430	1.17364996
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.16740436
37	RNA transport_Homo sapiens_hsa03013	1.15245462
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13244295
39	Spliceosome_Homo sapiens_hsa03040	1.12825547
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11786999
41	Alzheimers disease_Homo sapiens_hsa05010	1.11356384
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.08721641
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04593719
44	Purine metabolism_Homo sapiens_hsa00230	1.03787397
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.01076680
46	Peroxisome_Homo sapiens_hsa04146	0.96700984
47	Base excision repair_Homo sapiens_hsa03410	0.96512984
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96472159
49	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90366850
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89579605
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88000191
52	Viral myocarditis_Homo sapiens_hsa05416	0.86487588
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84758319
54	DNA replication_Homo sapiens_hsa03030	0.83249904
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.81382549
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.79917594
57	Sulfur metabolism_Homo sapiens_hsa00920	0.79502214
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76244606
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73098488
60	Butanoate metabolism_Homo sapiens_hsa00650	0.71860116
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.70719076
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69576665
63	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.67397801
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66562024
65	Leishmaniasis_Homo sapiens_hsa05140	0.58708335
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58598709
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.58346595
68	Herpes simplex infection_Homo sapiens_hsa05168	0.56268925
69	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.54535330
70	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.54103557
71	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.53939597
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53853616
73	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.53732156
74	Metabolic pathways_Homo sapiens_hsa01100	0.53059442
75	Regulation of autophagy_Homo sapiens_hsa04140	0.52006712
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51997481
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51602032
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49194360
79	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49182432
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47473289
81	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.46584381
82	Measles_Homo sapiens_hsa05162	0.46289970
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.43723316
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43705630
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43454244
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43080592
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41799662
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40275770
89	Retinol metabolism_Homo sapiens_hsa00830	0.38016453
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37526054
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36175126
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35884697
93	Glutathione metabolism_Homo sapiens_hsa00480	0.34679410
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32959918
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.32114264
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31005074
97	Fatty acid elongation_Homo sapiens_hsa00062	0.30249337
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30136642
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.29920579
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.28474557

EEF1A1P28

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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