ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.82084984
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.19186603
3	ATP synthesis coupled proton transport (GO:0015986)	4.11244039
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.11244039
5	water-soluble vitamin biosynthetic process (GO:0042364)	4.02964917
6	ribosomal small subunit assembly (GO:0000028)	4.00568966
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.87893416
8	protein complex biogenesis (GO:0070271)	3.62606784
9	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.56330837
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.55219703
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.55219703
12	NADH dehydrogenase complex assembly (GO:0010257)	3.55219703
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53308082
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53308082
15	proteasome assembly (GO:0043248)	3.51638232
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.47740235
17	regulation of cellular amino acid metabolic process (GO:0006521)	3.38329011
18	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.35340596
19	preassembly of GPI anchor in ER membrane (GO:0016254)	3.33483212
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29733137
21	cytidine deamination (GO:0009972)	3.26020051
22	cytidine metabolic process (GO:0046087)	3.26020051
23	cytidine catabolic process (GO:0006216)	3.26020051
24	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.25509162
25	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.24845920
26	mannosylation (GO:0097502)	3.23364718
27	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.18028065
28	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.18028065
29	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.18028065
30	protein-cofactor linkage (GO:0018065)	3.17877380
31	behavioral response to nicotine (GO:0035095)	3.16851561
32	positive regulation of prostaglandin secretion (GO:0032308)	3.15962005
33	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.13490308
34	termination of RNA polymerase III transcription (GO:0006386)	3.13490308
35	GTP biosynthetic process (GO:0006183)	3.11745872
36	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.11632054
37	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.11632054
38	protein neddylation (GO:0045116)	3.10337536
39	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.08576232
40	electron transport chain (GO:0022900)	3.07811345
41	respiratory electron transport chain (GO:0022904)	3.05113488
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.04474028
43	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.02400786
44	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.02400786
45	platelet dense granule organization (GO:0060155)	3.02179849
46	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.00592370
47	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.98589647
48	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.98065859
49	L-fucose catabolic process (GO:0042355)	2.96111185
50	fucose catabolic process (GO:0019317)	2.96111185
51	L-fucose metabolic process (GO:0042354)	2.96111185
52	ribosomal large subunit biogenesis (GO:0042273)	2.94767629
53	protein deneddylation (GO:0000338)	2.94756104
54	adenosine metabolic process (GO:0046085)	2.94100240
55	rRNA modification (GO:0000154)	2.90674777
56	cullin deneddylation (GO:0010388)	2.89077867
57	pseudouridine synthesis (GO:0001522)	2.84208304
58	negative regulation of ligase activity (GO:0051352)	2.82544065
59	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.82544065
60	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.82012882
61	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.81984888
62	regulation of isotype switching to IgG isotypes (GO:0048302)	2.78987404
63	regulation of regulatory T cell differentiation (GO:0045589)	2.78788198
64	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.77807143
65	respiratory chain complex IV assembly (GO:0008535)	2.77263531
66	positive regulation of defense response to virus by host (GO:0002230)	2.76182745
67	tRNA processing (GO:0008033)	2.75947636
68	sequestering of actin monomers (GO:0042989)	2.75712556
69	base-excision repair, AP site formation (GO:0006285)	2.74720960
70	negative regulation of telomere maintenance (GO:0032205)	2.74090481
71	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.72176268
72	chaperone-mediated protein transport (GO:0072321)	2.69836367
73	GPI anchor metabolic process (GO:0006505)	2.69383488
74	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.68961324
75	GMP metabolic process (GO:0046037)	2.67658525
76	GPI anchor biosynthetic process (GO:0006506)	2.66173863
77	regulation of immunoglobulin secretion (GO:0051023)	2.65807788
78	sleep (GO:0030431)	2.64658930
79	regulation of mitotic spindle checkpoint (GO:1903504)	2.64567110
80	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.64567110
81	iron-sulfur cluster assembly (GO:0016226)	2.63158839
82	metallo-sulfur cluster assembly (GO:0031163)	2.63158839
83	translational elongation (GO:0006414)	2.59640721
84	regulation of chronic inflammatory response (GO:0002676)	2.59571847
85	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.58191986
86	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.58191986
87	isotype switching (GO:0045190)	2.58191986
88	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.57755502
89	DNA catabolic process, exonucleolytic (GO:0000738)	2.56796686
90	viral transcription (GO:0019083)	2.55843214
91	response to interferon-beta (GO:0035456)	2.54453588
92	regulation of prostaglandin secretion (GO:0032306)	2.54194853
93	cotranslational protein targeting to membrane (GO:0006613)	2.54115018
94	maturation of SSU-rRNA (GO:0030490)	2.52733227
95	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.52300285
96	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	2.51987163
97	cytochrome complex assembly (GO:0017004)	2.51978030
98	negative regulation of mast cell activation (GO:0033004)	2.51972385
99	protein targeting to ER (GO:0045047)	2.51296757
100	translational termination (GO:0006415)	2.51036254

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.32718838
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.10550490
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.53567337
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.44305172
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.07616218
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99430220
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.96576489
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.84557671
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.77271320
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.74593555
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.68054502
12	VDR_22108803_ChIP-Seq_LS180_Human	2.58217971
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.51554138
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46652807
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.43223118
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34270675
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.33014062
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.30023304
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.11042875
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09243085
21	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.09089692
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05090892
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04970776
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.98307801
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92108455
26	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.89775306
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.89583556
28	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.80842910
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.80242599
30	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.75955585
31	EWS_26573619_Chip-Seq_HEK293_Human	1.75695036
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66548976
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.60255900
34	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.53071148
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.52472210
36	FUS_26573619_Chip-Seq_HEK293_Human	1.52155478
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46670033
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.44452009
39	GATA3_26560356_Chip-Seq_TH2_Human	1.41806555
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.40122680
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.39666329
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.39073338
43	AR_20517297_ChIP-Seq_VCAP_Human	1.39062954
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37020926
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36958653
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34945879
47	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34945879
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33862034
49	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29976235
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.29723667
51	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.29022785
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28419212
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.27924655
54	P300_19829295_ChIP-Seq_ESCs_Human	1.27538529
55	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.27011938
56	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23372882
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23127748
58	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.22925976
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22056335
60	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.21635909
61	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.21446567
62	MYB_26560356_Chip-Seq_TH2_Human	1.21073605
63	NCOR_22424771_ChIP-Seq_293T_Human	1.17820515
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.17340365
65	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.16901472
66	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.16338522
67	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.15962475
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15185096
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.15006880
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.15006880
71	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14664765
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.14493248
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14012831
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13474217
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13164099
76	TTF2_22483619_ChIP-Seq_HELA_Human	1.08123190
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.06831918
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06496994
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05952949
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04585928
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03625459
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02534957
83	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02364183
84	CBP_20019798_ChIP-Seq_JUKART_Human	1.02364183
85	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00247349
86	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.00242976
87	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.99980658
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99778740
89	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98794457
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.98760072
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98202797
92	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.97020242
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96540365
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.95561264
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95435705
96	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95053949
97	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.94958557
98	RUNX_20019798_ChIP-Seq_JUKART_Human	0.94913821
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94438009
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.92596341

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.78558702
2	MP0002102_abnormal_ear_morphology	3.30915846
3	MP0001835_abnormal_antigen_presentation	2.70054269
4	MP0008877_abnormal_DNA_methylation	2.54891657
5	MP0002138_abnormal_hepatobiliary_system	2.46672564
6	MP0008872_abnormal_physiological_respon	2.46403859
7	MP0006072_abnormal_retinal_apoptosis	2.43423967
8	MP0009785_altered_susceptibility_to	2.26410084
9	MP0001873_stomach_inflammation	2.23346464
10	MP0005075_abnormal_melanosome_morpholog	2.20398061
11	MP0008875_abnormal_xenobiotic_pharmacok	2.19591006
12	MP0000685_abnormal_immune_system	2.10418985
13	MP0004147_increased_porphyrin_level	2.09220817
14	MP0000372_irregular_coat_pigmentation	1.98289580
15	MP0003195_calcinosis	1.91770076
16	MP0002736_abnormal_nociception_after	1.88850091
17	MP0001800_abnormal_humoral_immune	1.86709530
18	MP0002148_abnormal_hypersensitivity_rea	1.85762519
19	MP0006292_abnormal_olfactory_placode	1.85007802
20	MP0005084_abnormal_gallbladder_morpholo	1.84867681
21	MP0003786_premature_aging	1.79538577
22	MP0001968_abnormal_touch/_nociception	1.75114148
23	MP0009333_abnormal_splenocyte_physiolog	1.73586882
24	MP0005551_abnormal_eye_electrophysiolog	1.69990309
25	MP0005000_abnormal_immune_tolerance	1.68290616
26	MP0008058_abnormal_DNA_repair	1.68205163
27	MP0004885_abnormal_endolymph	1.68029475
28	MP0005646_abnormal_pituitary_gland	1.67572912
29	MP0003763_abnormal_thymus_physiology	1.58150283
30	MP0002277_abnormal_respiratory_mucosa	1.53823068
31	MP0002723_abnormal_immune_serum	1.53404384
32	MP0003806_abnormal_nucleotide_metabolis	1.52052842
33	MP0002837_dystrophic_cardiac_calcinosis	1.51800447
34	MP0003724_increased_susceptibility_to	1.50419885
35	MP0003011_delayed_dark_adaptation	1.47019502
36	MP0005253_abnormal_eye_physiology	1.45772812
37	MP0008995_early_reproductive_senescence	1.44446504
38	MP0001790_abnormal_immune_system	1.41667832
39	MP0005387_immune_system_phenotype	1.41667832
40	MP0005645_abnormal_hypothalamus_physiol	1.40595412
41	MP0002420_abnormal_adaptive_immunity	1.39045927
42	MP0001819_abnormal_immune_cell	1.38496045
43	MP0002166_altered_tumor_susceptibility	1.38262039
44	MP0002452_abnormal_antigen_presenting	1.37575263
45	MP0002006_tumorigenesis	1.36866873
46	MP0001986_abnormal_taste_sensitivity	1.33025835
47	MP0004142_abnormal_muscle_tone	1.33021480
48	MP0009764_decreased_sensitivity_to	1.28835803
49	MP0002876_abnormal_thyroid_physiology	1.28430303
50	MP0002933_joint_inflammation	1.22874572
51	MP0001905_abnormal_dopamine_level	1.21582283
52	MP0006082_CNS_inflammation	1.18946671
53	MP0003866_abnormal_defecation	1.17478104
54	MP0002095_abnormal_skin_pigmentation	1.16153708
55	MP0002234_abnormal_pharynx_morphology	1.15006440
56	MP0001764_abnormal_homeostasis	1.14986714
57	MP0002938_white_spotting	1.08339700
58	MP0006036_abnormal_mitochondrial_physio	1.08139290
59	MP0003646_muscle_fatigue	1.07235112
60	MP0003878_abnormal_ear_physiology	1.06970457
61	MP0005377_hearing/vestibular/ear_phenot	1.06970457
62	MP0004145_abnormal_muscle_electrophysio	1.05733823
63	MP0002405_respiratory_system_inflammati	1.05608404
64	MP0001919_abnormal_reproductive_system	1.04797368
65	MP0001845_abnormal_inflammatory_respons	1.04659373
66	MP0005389_reproductive_system_phenotype	1.03981788
67	MP0001529_abnormal_vocalization	1.03669074
68	MP0002163_abnormal_gland_morphology	1.03137111
69	MP0000689_abnormal_spleen_morphology	1.01376293
70	MP0005025_abnormal_response_to	1.00652377
71	MP0003436_decreased_susceptibility_to	0.99976157
72	MP0005085_abnormal_gallbladder_physiolo	0.99600318
73	MP0005410_abnormal_fertilization	0.99058784
74	MP0000716_abnormal_immune_system	0.96065065
75	MP0003950_abnormal_plasma_membrane	0.94824200
76	MP0002398_abnormal_bone_marrow	0.93017019
77	MP0010155_abnormal_intestine_physiology	0.92154306
78	MP0003718_maternal_effect	0.87586976
79	MP0004742_abnormal_vestibular_system	0.86948502
80	MP0003283_abnormal_digestive_organ	0.85878564
81	MP0008469_abnormal_protein_level	0.85349730
82	MP0000383_abnormal_hair_follicle	0.84565228
83	MP0006276_abnormal_autonomic_nervous	0.83657201
84	MP0002693_abnormal_pancreas_physiology	0.83382839
85	MP0003252_abnormal_bile_duct	0.82956302
86	MP0003136_yellow_coat_color	0.82446316
87	MP0002722_abnormal_immune_system	0.80677601
88	MP0001533_abnormal_skeleton_physiology	0.79759334
89	MP0002429_abnormal_blood_cell	0.77114272
90	MP0005332_abnormal_amino_acid	0.76838349
91	MP0002272_abnormal_nervous_system	0.76378078
92	MP0002638_abnormal_pupillary_reflex	0.76238890
93	MP0005379_endocrine/exocrine_gland_phen	0.75294535
94	MP0000427_abnormal_hair_cycle	0.74329148
95	MP0005636_abnormal_mineral_homeostasis	0.73781316
96	MP0001501_abnormal_sleep_pattern	0.73681465
97	MP0003638_abnormal_response/metabolism_	0.73572620
98	MP0002419_abnormal_innate_immunity	0.72871946
99	MP0003186_abnormal_redox_activity	0.72160896
100	MP0000703_abnormal_thymus_morphology	0.71808277

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	3.77901029
2	Acute necrotizing encephalopathy (HP:0006965)	3.67342554
3	IgG deficiency (HP:0004315)	3.66124813
4	Increased hepatocellular lipid droplets (HP:0006565)	3.56133525
5	3-Methylglutaconic aciduria (HP:0003535)	3.45246251
6	Increased CSF lactate (HP:0002490)	3.42926164
7	Lipid accumulation in hepatocytes (HP:0006561)	3.34724551
8	Congenital, generalized hypertrichosis (HP:0004540)	3.26593277
9	Acute encephalopathy (HP:0006846)	3.25202133
10	Hepatocellular necrosis (HP:0001404)	3.24132372
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.21685775
12	Pancreatic cysts (HP:0001737)	3.14755288
13	Hepatic necrosis (HP:0002605)	3.08398908
14	Progressive macrocephaly (HP:0004481)	3.06995619
15	Congenital stationary night blindness (HP:0007642)	3.04830632
16	Stomatitis (HP:0010280)	3.04422243
17	Methylmalonic acidemia (HP:0002912)	3.00150674
18	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.91545229
19	Attenuation of retinal blood vessels (HP:0007843)	2.89530067
20	Abnormality of the renal cortex (HP:0011035)	2.87850435
21	Constricted visual fields (HP:0001133)	2.83428475
22	Renal Fanconi syndrome (HP:0001994)	2.82707120
23	Renal cortical cysts (HP:0000803)	2.81678062
24	True hermaphroditism (HP:0010459)	2.79006895
25	Optic disc pallor (HP:0000543)	2.75786834
26	Increased serum lactate (HP:0002151)	2.70890170
27	Increased IgM level (HP:0003496)	2.66141784
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.66067217
29	Abolished electroretinogram (ERG) (HP:0000550)	2.66003757
30	Hypoproteinemia (HP:0003075)	2.64364423
31	Methylmalonic aciduria (HP:0012120)	2.54378923
32	Molar tooth sign on MRI (HP:0002419)	2.53804589
33	Abnormality of midbrain morphology (HP:0002418)	2.53804589
34	Lactic acidosis (HP:0003128)	2.47614500
35	Oral leukoplakia (HP:0002745)	2.46620732
36	Abnormality of the pons (HP:0007361)	2.46466866
37	Stomach cancer (HP:0012126)	2.46108813
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.45764301
39	Cerebral edema (HP:0002181)	2.45601717
40	Type I transferrin isoform profile (HP:0003642)	2.45210905
41	Pancreatic fibrosis (HP:0100732)	2.42068193
42	Increased intramyocellular lipid droplets (HP:0012240)	2.40787683
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.38428687
44	Abnormality of alanine metabolism (HP:0010916)	2.38428687
45	Hyperalaninemia (HP:0003348)	2.38428687
46	Abnormal number of erythroid precursors (HP:0012131)	2.36443762
47	Exertional dyspnea (HP:0002875)	2.36051260
48	Abnormality of the prostate (HP:0008775)	2.35324246
49	Type 2 muscle fiber atrophy (HP:0003554)	2.32869964
50	Abnormality of T cell number (HP:0011839)	2.24545600
51	Aplastic anemia (HP:0001915)	2.22474083
52	Nephronophthisis (HP:0000090)	2.20980298
53	Pancytopenia (HP:0001876)	2.19110215
54	Elevated erythrocyte sedimentation rate (HP:0003565)	2.14752506
55	Colon cancer (HP:0003003)	2.12811019
56	Hypoplasia of the pons (HP:0012110)	2.11411990
57	Abnormality of T cells (HP:0002843)	2.10824142
58	Abnormality of B cell number (HP:0010975)	2.10489070
59	Prostate neoplasm (HP:0100787)	2.08807399
60	Severe combined immunodeficiency (HP:0004430)	2.06795263
61	Aplasia/hypoplasia of the uterus (HP:0008684)	2.06619300
62	Hyperglycinemia (HP:0002154)	2.04530068
63	Abnormal protein glycosylation (HP:0012346)	2.03134493
64	Abnormal glycosylation (HP:0012345)	2.03134493
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.03134493
66	Abnormal protein N-linked glycosylation (HP:0012347)	2.03134493
67	Abnormality of the renal medulla (HP:0100957)	2.03074938
68	T lymphocytopenia (HP:0005403)	2.01670614
69	Bile duct proliferation (HP:0001408)	2.00708465
70	Abnormal biliary tract physiology (HP:0012439)	2.00708465
71	Abnormality of urine glucose concentration (HP:0011016)	1.99663437
72	Glycosuria (HP:0003076)	1.99663437
73	Respiratory failure (HP:0002878)	1.98288639
74	Increased corneal curvature (HP:0100692)	1.97077420
75	Keratoconus (HP:0000563)	1.97077420
76	Lethargy (HP:0001254)	1.97000272
77	Type II lissencephaly (HP:0007260)	1.96958156
78	Abnormality of cells of the erythroid lineage (HP:0012130)	1.96833574
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.96712104
80	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.96518486
81	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.96028099
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.96028099
83	Pendular nystagmus (HP:0012043)	1.95941492
84	Increased muscle lipid content (HP:0009058)	1.95826917
85	Autoimmune hemolytic anemia (HP:0001890)	1.95586327
86	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.95466657
87	Abnormal drinking behavior (HP:0030082)	1.93414910
88	Polydipsia (HP:0001959)	1.93414910
89	Decreased central vision (HP:0007663)	1.91442891
90	Large for gestational age (HP:0001520)	1.90145034
91	Abnormality of eosinophils (HP:0001879)	1.89193973
92	Abnormality of T cell physiology (HP:0011840)	1.87801519
93	Exercise intolerance (HP:0003546)	1.87105767
94	Abnormality of serum amino acid levels (HP:0003112)	1.86670537
95	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84232827
96	Asplenia (HP:0001746)	1.83852195
97	Absent thumb (HP:0009777)	1.82820677
98	Delayed CNS myelination (HP:0002188)	1.82565891
99	Muscle fiber atrophy (HP:0100295)	1.81223356
100	Polyuria (HP:0000103)	1.79742442

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.55794221
2	TLK1	3.53927186
3	ZAK	3.45324364
4	VRK2	3.27990095
5	MAP4K2	3.15238131
6	TAOK3	2.67062034
7	NUAK1	2.54390236
8	BCKDK	2.51616251
9	ADRBK2	2.36972699
10	VRK1	2.09219450
11	MST4	2.04880517
12	GRK1	1.95054388
13	TSSK6	1.82521525
14	FRK	1.82343495
15	PINK1	1.77621872
16	PASK	1.71961373
17	KIT	1.69724404
18	KDR	1.68056469
19	TIE1	1.64124294
20	EIF2AK3	1.59730718
21	BUB1	1.53767090
22	MAP4K1	1.51199328
23	TAF1	1.47382390
24	TEC	1.46369583
25	FES	1.44982678
26	IKBKB	1.44271490
27	CDK19	1.42702284
28	STK16	1.42403515
29	CDK8	1.36352309
30	MAPKAPK3	1.30009493
31	BMPR1B	1.27857611
32	WNK3	1.25368256
33	MAP3K12	1.24892377
34	GRK6	1.20473927
35	TESK2	1.16930837
36	ITK	1.11804519
37	NME1	1.08733228
38	IKBKE	1.01062248
39	DAPK1	1.00323897
40	PLK3	0.98068304
41	SRPK1	0.97285002
42	OXSR1	0.94856984
43	EIF2AK2	0.92630828
44	INSRR	0.89451641
45	SYK	0.88477529
46	PLK4	0.84327464
47	ADRBK1	0.83993661
48	TRIM28	0.83838812
49	PHKG2	0.82990653
50	PHKG1	0.82990653
51	ERBB3	0.81699071
52	ACVR1B	0.81374496
53	MAPKAPK5	0.80739818
54	GRK7	0.77788439
55	GRK5	0.76219454
56	MAP3K4	0.75549449
57	WNK4	0.75317284
58	MAP2K6	0.75145155
59	NEK1	0.73338741
60	CSNK1G3	0.72845137
61	MAP3K14	0.72081315
62	MUSK	0.70420159
63	TGFBR1	0.69963732
64	DYRK2	0.69393825
65	LIMK1	0.65527103
66	CAMKK2	0.65508406
67	PRKCQ	0.65469901
68	RPS6KA5	0.65317008
69	MAP2K7	0.62093892
70	MKNK1	0.60855195
71	CSNK1G1	0.60086865
72	MAP2K2	0.57260098
73	DAPK2	0.56079801
74	CSF1R	0.55832380
75	TBK1	0.53770757
76	CSNK1G2	0.51428927
77	LYN	0.50094502
78	LCK	0.49259903
79	PRKCE	0.47341568
80	CSNK1A1L	0.47246217
81	IGF1R	0.45496034
82	ATR	0.43764720
83	SCYL2	0.41803358
84	BMPR2	0.40708916
85	MAPK13	0.39517012
86	MYLK	0.39480809
87	PDK2	0.39238701
88	CCNB1	0.39157391
89	BTK	0.37311502
90	PLK2	0.37243390
91	JAK3	0.33557648
92	CSNK1A1	0.33344156
93	CSNK2A1	0.32494721
94	RPS6KA4	0.30888679
95	FLT3	0.30877405
96	PRKACA	0.30303240
97	PLK1	0.30034565
98	PRKCA	0.29332819
99	STK39	0.29089350
100	ABL1	0.28481894

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.10383197
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.15986595
3	Ribosome_Homo sapiens_hsa03010	2.83628855
4	Allograft rejection_Homo sapiens_hsa05330	2.50728933
5	Asthma_Homo sapiens_hsa05310	2.49755455
6	Parkinsons disease_Homo sapiens_hsa05012	2.44609902
7	RNA polymerase_Homo sapiens_hsa03020	2.41888751
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.38956633
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.32796917
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.28560800
11	Protein export_Homo sapiens_hsa03060	2.27155990
12	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.25377342
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.14348913
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.04125558
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.83411713
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.78299510
17	Phototransduction_Homo sapiens_hsa04744	1.67720788
18	Homologous recombination_Homo sapiens_hsa03440	1.66744837
19	One carbon pool by folate_Homo sapiens_hsa00670	1.60654405
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.60440655
21	RNA degradation_Homo sapiens_hsa03018	1.59538704
22	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.57228230
23	Mismatch repair_Homo sapiens_hsa03430	1.55733719
24	Alzheimers disease_Homo sapiens_hsa05010	1.54162114
25	Huntingtons disease_Homo sapiens_hsa05016	1.52007999
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.36637986
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34789123
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33858851
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.32367181
30	Rheumatoid arthritis_Homo sapiens_hsa05323	1.30356918
31	Basal transcription factors_Homo sapiens_hsa03022	1.25212432
32	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24372391
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.24171954
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20822335
35	Caffeine metabolism_Homo sapiens_hsa00232	1.17594231
36	Propanoate metabolism_Homo sapiens_hsa00640	1.17188851
37	DNA replication_Homo sapiens_hsa03030	1.16485638
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.16061550
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.11424969
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.09877637
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.07842488
42	Purine metabolism_Homo sapiens_hsa00230	1.07592789
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.06244141
44	Sulfur metabolism_Homo sapiens_hsa00920	1.05320325
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03999871
46	Base excision repair_Homo sapiens_hsa03410	1.03801710
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99151350
48	Peroxisome_Homo sapiens_hsa04146	0.98982095
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96968092
50	Spliceosome_Homo sapiens_hsa03040	0.96635086
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96572266
52	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.89828733
53	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.85209919
54	RNA transport_Homo sapiens_hsa03013	0.84503898
55	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83903386
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82716518
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.82282026
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.79719411
59	Butanoate metabolism_Homo sapiens_hsa00650	0.78784991
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77087858
61	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74413764
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.73199464
63	Fatty acid elongation_Homo sapiens_hsa00062	0.67483928
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67131263
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66091104
66	Metabolic pathways_Homo sapiens_hsa01100	0.63271132
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63025701
68	Viral myocarditis_Homo sapiens_hsa05416	0.62497767
69	Retinol metabolism_Homo sapiens_hsa00830	0.61027635
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60901321
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60761890
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60213861
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59312488
74	Regulation of autophagy_Homo sapiens_hsa04140	0.58557051
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.58319014
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57715975
77	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.55141750
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55037056
79	Glutathione metabolism_Homo sapiens_hsa00480	0.55030562
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.54906562
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54753783
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.52269322
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.52207754
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51118916
85	Olfactory transduction_Homo sapiens_hsa04740	0.50300612
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.49313804
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49078587
88	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.46848796
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.45868799
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.45613386
91	Folate biosynthesis_Homo sapiens_hsa00790	0.44139515
92	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.42909003
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.42097132
94	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41116667
95	Taste transduction_Homo sapiens_hsa04742	0.37984436
96	Herpes simplex infection_Homo sapiens_hsa05168	0.33972107
97	Measles_Homo sapiens_hsa05162	0.32956038
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31502395
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.29625331
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.28580026

EEF1A1P29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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