ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.42434332
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.57268377
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.08275934
4	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.08275934
5	piRNA metabolic process (GO:0034587)	3.84283916
6	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.73099074
7	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.68500040
8	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.64543636
9	maturation of SSU-rRNA (GO:0030490)	3.62896371
10	rRNA modification (GO:0000154)	3.62443488
11	L-fucose metabolic process (GO:0042354)	3.53908745
12	L-fucose catabolic process (GO:0042355)	3.53908745
13	fucose catabolic process (GO:0019317)	3.53908745
14	behavioral response to nicotine (GO:0035095)	3.52638962
15	protein complex biogenesis (GO:0070271)	3.52061844
16	ribosomal small subunit assembly (GO:0000028)	3.42192885
17	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.37340210
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.37340210
19	NADH dehydrogenase complex assembly (GO:0010257)	3.37340210
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.34007765
21	respiratory chain complex IV assembly (GO:0008535)	3.32486239
22	mitochondrial respiratory chain complex assembly (GO:0033108)	3.29968657
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.24539323
24	ATP synthesis coupled proton transport (GO:0015986)	3.24539323
25	protein neddylation (GO:0045116)	3.18480472
26	rRNA methylation (GO:0031167)	3.10307189
27	dopamine transport (GO:0015872)	3.08166837
28	pseudouridine synthesis (GO:0001522)	3.07356688
29	GTP biosynthetic process (GO:0006183)	3.05772287
30	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.00175747
31	aldehyde catabolic process (GO:0046185)	2.99920530
32	base-excision repair, AP site formation (GO:0006285)	2.99915932
33	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.99885101
34	regulation of mitotic spindle checkpoint (GO:1903504)	2.99885101
35	proteasome assembly (GO:0043248)	2.99530530
36	replication fork processing (GO:0031297)	2.97815924
37	cytochrome complex assembly (GO:0017004)	2.93619763
38	CTP biosynthetic process (GO:0006241)	2.92810263
39	CTP metabolic process (GO:0046036)	2.92810263
40	DNA double-strand break processing (GO:0000729)	2.91957570
41	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.88480496
42	tRNA processing (GO:0008033)	2.88157235
43	DNA methylation involved in gamete generation (GO:0043046)	2.81306671
44	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.79945964
45	lactate metabolic process (GO:0006089)	2.79357529
46	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.78397108
47	cell wall macromolecule metabolic process (GO:0044036)	2.76256040
48	synapsis (GO:0007129)	2.75673877
49	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.75397956
50	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.75397956
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.75397956
52	chaperone-mediated protein transport (GO:0072321)	2.72768746
53	response to pheromone (GO:0019236)	2.72766346
54	DNA catabolic process, exonucleolytic (GO:0000738)	2.71327226
55	maturation of 5.8S rRNA (GO:0000460)	2.70680140
56	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.68145936
57	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.68145936
58	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.67242411
59	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.66813234
60	recombinational repair (GO:0000725)	2.66430467
61	tRNA modification (GO:0006400)	2.65043912
62	double-strand break repair via homologous recombination (GO:0000724)	2.64979869
63	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.63990534
64	isotype switching (GO:0045190)	2.63990534
65	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.63990534
66	regulation of isotype switching to IgG isotypes (GO:0048302)	2.62257942
67	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.60758872
68	negative regulation of B cell apoptotic process (GO:0002903)	2.60113784
69	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.60076002
70	translation (GO:0006412)	2.59898167
71	regulation of cellular amino acid metabolic process (GO:0006521)	2.59656272
72	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.55834833
73	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.55834833
74	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.55733861
75	indolalkylamine metabolic process (GO:0006586)	2.54397422
76	rRNA processing (GO:0006364)	2.53546041
77	rRNA metabolic process (GO:0016072)	2.53182493
78	platelet dense granule organization (GO:0060155)	2.53038574
79	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.52764717
80	translational termination (GO:0006415)	2.52678801
81	viral transcription (GO:0019083)	2.52063475
82	DNA demethylation (GO:0080111)	2.51440740
83	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.49558849
84	DNA dealkylation (GO:0035510)	2.47144331
85	regulation of immunoglobulin secretion (GO:0051023)	2.47030959
86	positive regulation of prostaglandin secretion (GO:0032308)	2.46846013
87	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.45504378
88	UTP biosynthetic process (GO:0006228)	2.44888635
89	purine-containing compound salvage (GO:0043101)	2.44771651
90	translational elongation (GO:0006414)	2.43795188
91	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.43476247
92	negative regulation of telomere maintenance (GO:0032205)	2.43049239
93	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.42013230
94	protein-cofactor linkage (GO:0018065)	2.41909193
95	RNA phosphodiester bond hydrolysis (GO:0090501)	2.40835075
96	peptidyl-histidine modification (GO:0018202)	2.40616052
97	cotranslational protein targeting to membrane (GO:0006613)	2.40525545
98	tRNA metabolic process (GO:0006399)	2.39636296
99	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.39420199
100	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.38339889

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.70774781
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65755875
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.52983851
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.22477110
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.06313198
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.99455562
7	VDR_22108803_ChIP-Seq_LS180_Human	2.96293912
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.66056140
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.61947899
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.57040422
11	ELK1_19687146_ChIP-ChIP_HELA_Human	2.43366548
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.40402601
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.35891042
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31098966
15	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.28991888
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.21948486
17	EWS_26573619_Chip-Seq_HEK293_Human	2.17405172
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.15947620
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03872841
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00671770
21	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00284617
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.98079109
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.97469203
24	FUS_26573619_Chip-Seq_HEK293_Human	1.91755404
25	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76485905
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.73495399
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.71651783
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.70916142
29	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.66645513
30	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.65777743
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64092754
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.63663985
33	P300_19829295_ChIP-Seq_ESCs_Human	1.59926308
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.59312886
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57109587
36	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.55809412
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.55251473
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54484816
39	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54468633
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.53438692
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.52763152
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.46786197
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45590207
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.44725132
45	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44576973
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44364322
47	GATA3_26560356_Chip-Seq_TH2_Human	1.43524716
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.41048663
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.35935629
50	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.32898804
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.31539752
52	BCAT_22108803_ChIP-Seq_LS180_Human	1.31223014
53	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30696982
54	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29543503
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28405947
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28405947
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.27362993
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26412314
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22239475
60	GBX2_23144817_ChIP-Seq_PC3_Human	1.22117160
61	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.21172104
62	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20872411
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20586389
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20586389
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19865694
66	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19801370
67	CBP_20019798_ChIP-Seq_JUKART_Human	1.19801370
68	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.18229435
69	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.18228856
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.15764509
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.15288864
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.15180808
73	AR_20517297_ChIP-Seq_VCAP_Human	1.14397001
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12616415
75	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.10671565
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08715926
77	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.04840914
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03482079
79	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01840693
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98344421
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98023909
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.95677701
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95455538
84	CDX2_22108803_ChIP-Seq_LS180_Human	0.94126558
85	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.92981487
86	TCF4_23295773_ChIP-Seq_U87_Human	0.92839750
87	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92600407
88	STAT3_23295773_ChIP-Seq_U87_Human	0.91836689
89	MYB_26560356_Chip-Seq_TH2_Human	0.91650830
90	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90346956
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.90261569
92	GABP_19822575_ChIP-Seq_HepG2_Human	0.89529354
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89346460
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.88278119
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.88066009
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.88023278
97	TTF2_22483619_ChIP-Seq_HELA_Human	0.87975839
98	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.87898620
99	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.87497593
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87108364

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.43399896
2	MP0001835_abnormal_antigen_presentation	3.03893048
3	MP0002102_abnormal_ear_morphology	2.96792536
4	MP0002138_abnormal_hepatobiliary_system	2.82977755
5	MP0003195_calcinosis	2.56093233
6	MP0006292_abnormal_olfactory_placode	2.51634061
7	MP0008058_abnormal_DNA_repair	2.40351740
8	MP0006072_abnormal_retinal_apoptosis	2.35997727
9	MP0008872_abnormal_physiological_respon	2.30794515
10	MP0005671_abnormal_response_to	2.21264174
11	MP0003283_abnormal_digestive_organ	2.18770690
12	MP0000372_irregular_coat_pigmentation	2.13334781
13	MP0008875_abnormal_xenobiotic_pharmacok	2.12152489
14	MP0003787_abnormal_imprinting	2.02672818
15	MP0005075_abnormal_melanosome_morpholog	1.80015662
16	MP0000569_abnormal_digit_pigmentation	1.78341752
17	MP0003718_maternal_effect	1.74297662
18	MP0003646_muscle_fatigue	1.70967957
19	MP0002736_abnormal_nociception_after	1.65821017
20	MP0005084_abnormal_gallbladder_morpholo	1.59618834
21	MP0001986_abnormal_taste_sensitivity	1.57744749
22	MP0005646_abnormal_pituitary_gland	1.57188187
23	MP0005551_abnormal_eye_electrophysiolog	1.54861282
24	MP0005253_abnormal_eye_physiology	1.49090169
25	MP0001968_abnormal_touch/_nociception	1.47686816
26	MP0005360_urolithiasis	1.46763322
27	MP0003786_premature_aging	1.46548348
28	MP0010094_abnormal_chromosome_stability	1.44814687
29	MP0005645_abnormal_hypothalamus_physiol	1.43015064
30	MP0002234_abnormal_pharynx_morphology	1.42778984
31	MP0008995_early_reproductive_senescence	1.40545303
32	MP0001800_abnormal_humoral_immune	1.39255674
33	MP0003252_abnormal_bile_duct	1.37975173
34	MP0001529_abnormal_vocalization	1.32912124
35	MP0001873_stomach_inflammation	1.31982202
36	MP0004142_abnormal_muscle_tone	1.31465792
37	MP0002163_abnormal_gland_morphology	1.30977934
38	MP0009697_abnormal_copulation	1.30510040
39	MP0003011_delayed_dark_adaptation	1.25096573
40	MP0002148_abnormal_hypersensitivity_rea	1.23573332
41	MP0003806_abnormal_nucleotide_metabolis	1.21200231
42	MP0009785_altered_susceptibility_to	1.18624452
43	MP0000427_abnormal_hair_cycle	1.16431265
44	MP0009764_decreased_sensitivity_to	1.16367840
45	MP0004742_abnormal_vestibular_system	1.15872048
46	MP0002277_abnormal_respiratory_mucosa	1.15842029
47	MP0002166_altered_tumor_susceptibility	1.14662728
48	MP0006276_abnormal_autonomic_nervous	1.11871244
49	MP0004885_abnormal_endolymph	1.11454925
50	MP0003567_abnormal_fetal_cardiomyocyte	1.10513009
51	MP0003186_abnormal_redox_activity	1.08847625
52	MP0001501_abnormal_sleep_pattern	1.06607493
53	MP0001790_abnormal_immune_system	1.06034796
54	MP0005387_immune_system_phenotype	1.06034796
55	MP0000685_abnormal_immune_system	1.05648065
56	MP0002723_abnormal_immune_serum	1.05436455
57	MP0005389_reproductive_system_phenotype	1.04198948
58	MP0008057_abnormal_DNA_replication	1.04107170
59	MP0002938_white_spotting	1.02473495
60	MP0005000_abnormal_immune_tolerance	1.01461150
61	MP0002006_tumorigenesis	0.99913718
62	MP0006035_abnormal_mitochondrial_morpho	0.99438257
63	MP0004145_abnormal_muscle_electrophysio	0.97041093
64	MP0001919_abnormal_reproductive_system	0.96755651
65	MP0001929_abnormal_gametogenesis	0.96731694
66	MP0003763_abnormal_thymus_physiology	0.96330577
67	MP0005379_endocrine/exocrine_gland_phen	0.95422843
68	MP0003693_abnormal_embryo_hatching	0.95235013
69	MP0002452_abnormal_antigen_presenting	0.94672717
70	MP0002420_abnormal_adaptive_immunity	0.94563921
71	MP0002638_abnormal_pupillary_reflex	0.93846046
72	MP0001819_abnormal_immune_cell	0.93564058
73	MP0000689_abnormal_spleen_morphology	0.92347986
74	MP0002837_dystrophic_cardiac_calcinosis	0.91886768
75	MP0001293_anophthalmia	0.90774291
76	MP0001984_abnormal_olfaction	0.89089616
77	MP0001905_abnormal_dopamine_level	0.88814432
78	MP0001119_abnormal_female_reproductive	0.88096352
79	MP0002254_reproductive_system_inflammat	0.88095682
80	MP0005410_abnormal_fertilization	0.87901718
81	MP0000653_abnormal_sex_gland	0.87675813
82	MP0002210_abnormal_sex_determination	0.87460795
83	MP0000538_abnormal_urinary_bladder	0.87333430
84	MP0000613_abnormal_salivary_gland	0.86900002
85	MP0001764_abnormal_homeostasis	0.86775760
86	MP0006036_abnormal_mitochondrial_physio	0.86697735
87	MP0008007_abnormal_cellular_replicative	0.85919456
88	MP0009379_abnormal_foot_pigmentation	0.84096454
89	MP0004381_abnormal_hair_follicle	0.83796779
90	MP0005174_abnormal_tail_pigmentation	0.81953668
91	MP0005310_abnormal_salivary_gland	0.81576569
92	MP0002876_abnormal_thyroid_physiology	0.81449617
93	MP0001440_abnormal_grooming_behavior	0.80091582
94	MP0002095_abnormal_skin_pigmentation	0.79611328
95	MP0003121_genomic_imprinting	0.79246792
96	MP0002398_abnormal_bone_marrow	0.79129018
97	MP0004147_increased_porphyrin_level	0.79127789
98	MP0002751_abnormal_autonomic_nervous	0.77122886
99	MP0003724_increased_susceptibility_to	0.77097552
100	MP0005332_abnormal_amino_acid	0.76843173

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypothermia (HP:0002045)	3.58268527
2	Acute necrotizing encephalopathy (HP:0006965)	3.32738764
3	Pancreatic cysts (HP:0001737)	3.30023604
4	Progressive macrocephaly (HP:0004481)	3.26246423
5	Stomach cancer (HP:0012126)	3.10919969
6	Mitochondrial inheritance (HP:0001427)	3.07527889
7	Increased CSF lactate (HP:0002490)	3.05332315
8	Acute encephalopathy (HP:0006846)	3.03951301
9	Pancreatic fibrosis (HP:0100732)	2.98870090
10	Congenital stationary night blindness (HP:0007642)	2.91329061
11	Abnormality of the renal cortex (HP:0011035)	2.83965060
12	Abnormal mitochondria in muscle tissue (HP:0008316)	2.83349938
13	Chronic otitis media (HP:0000389)	2.81397602
14	Abnormality of the pons (HP:0007361)	2.80144634
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.67637904
16	True hermaphroditism (HP:0010459)	2.66089895
17	Molar tooth sign on MRI (HP:0002419)	2.65338600
18	Abnormality of midbrain morphology (HP:0002418)	2.65338600
19	Hepatocellular necrosis (HP:0001404)	2.65185703
20	Nephronophthisis (HP:0000090)	2.65132962
21	Increased hepatocellular lipid droplets (HP:0006565)	2.65018300
22	Stomatitis (HP:0010280)	2.62902424
23	Thyroiditis (HP:0100646)	2.62339169
24	Colon cancer (HP:0003003)	2.61497777
25	Methylmalonic acidemia (HP:0002912)	2.53873047
26	IgG deficiency (HP:0004315)	2.52934199
27	Congenital, generalized hypertrichosis (HP:0004540)	2.52664195
28	Attenuation of retinal blood vessels (HP:0007843)	2.51692175
29	Abnormality of the renal medulla (HP:0100957)	2.49700200
30	Abnormality of the labia minora (HP:0012880)	2.47299767
31	Abolished electroretinogram (ERG) (HP:0000550)	2.44972522
32	Hypoplasia of the pons (HP:0012110)	2.40955860
33	Hypoproteinemia (HP:0003075)	2.39912652
34	Lipid accumulation in hepatocytes (HP:0006561)	2.38954832
35	Optic disc pallor (HP:0000543)	2.37842239
36	Hepatic necrosis (HP:0002605)	2.34687740
37	Increased serum lactate (HP:0002151)	2.30098819
38	Alveolar cell carcinoma (HP:0006519)	2.26367182
39	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.24908293
40	Abnormality of B cell number (HP:0010975)	2.21504978
41	Hypomagnesemia (HP:0002917)	2.19599654
42	Prostate neoplasm (HP:0100787)	2.18203475
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.16267832
44	Abnormal drinking behavior (HP:0030082)	2.16129224
45	Polydipsia (HP:0001959)	2.16129224
46	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.11899909
47	Panhypogammaglobulinemia (HP:0003139)	2.10227830
48	Exertional dyspnea (HP:0002875)	2.10024541
49	Pendular nystagmus (HP:0012043)	2.09076592
50	Abnormality of the prostate (HP:0008775)	2.08561489
51	Severe combined immunodeficiency (HP:0004430)	2.07933998
52	Cerebral edema (HP:0002181)	2.06523288
53	Methylmalonic aciduria (HP:0012120)	2.06148338
54	Polyuria (HP:0000103)	2.05913781
55	Chronic sinusitis (HP:0011109)	2.05677199
56	Type I transferrin isoform profile (HP:0003642)	2.03421728
57	Medial flaring of the eyebrow (HP:0010747)	2.02822481
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.01348354
59	Abnormality of T cells (HP:0002843)	1.96727561
60	3-Methylglutaconic aciduria (HP:0003535)	1.95462682
61	Volvulus (HP:0002580)	1.94282922
62	B lymphocytopenia (HP:0010976)	1.93640211
63	Absent thumb (HP:0009777)	1.93003662
64	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.92477152
65	Abnormality of alanine metabolism (HP:0010916)	1.92477152
66	Hyperalaninemia (HP:0003348)	1.92477152
67	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.91369766
68	Abnormal number of erythroid precursors (HP:0012131)	1.91201581
69	Renal cortical cysts (HP:0000803)	1.90768134
70	Neoplasm of the tracheobronchial system (HP:0100552)	1.89955669
71	Intestinal atresia (HP:0011100)	1.88924606
72	Renal Fanconi syndrome (HP:0001994)	1.88697663
73	Abnormality of T cell physiology (HP:0011840)	1.88268132
74	Autoimmune hemolytic anemia (HP:0001890)	1.86158015
75	Reticulocytopenia (HP:0001896)	1.86061830
76	Tubular atrophy (HP:0000092)	1.86009124
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84920711
78	Abnormal biliary tract physiology (HP:0012439)	1.84900210
79	Bile duct proliferation (HP:0001408)	1.84900210
80	Lethargy (HP:0001254)	1.84762811
81	Lactic acidosis (HP:0003128)	1.84729520
82	Abnormality of the ileum (HP:0001549)	1.82641105
83	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.79932636
84	Abnormality of chromosome stability (HP:0003220)	1.76070265
85	Hyperglycinemia (HP:0002154)	1.74390926
86	Abnormality of cells of the erythroid lineage (HP:0012130)	1.73587611
87	Carpal bone hypoplasia (HP:0001498)	1.72762242
88	Bilateral microphthalmos (HP:0007633)	1.72413801
89	Abnormality of vitamin B metabolism (HP:0004340)	1.71811731
90	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.71133301
91	Meckel diverticulum (HP:0002245)	1.70859644
92	Decreased central vision (HP:0007663)	1.69715552
93	Abnormal protein glycosylation (HP:0012346)	1.69675812
94	Abnormal glycosylation (HP:0012345)	1.69675812
95	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.69675812
96	Abnormal protein N-linked glycosylation (HP:0012347)	1.69675812
97	Clubbing of toes (HP:0100760)	1.69454895
98	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.69384136
99	Constricted visual fields (HP:0001133)	1.68448431
100	Cystic liver disease (HP:0006706)	1.68301915

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.37471920
2	TAOK3	3.19879638
3	NUAK1	3.14940403
4	ZAK	3.13536520
5	TLK1	3.03696864
6	MAP4K2	3.01229141
7	BMPR1B	2.75049839
8	MST4	2.72501739
9	TXK	2.39200091
10	EIF2AK3	2.29395614
11	ADRBK2	2.23022211
12	GRK1	2.15609492
13	STK16	2.15420846
14	VRK2	2.14739491
15	WNK3	1.75009381
16	TSSK6	1.63291008
17	VRK1	1.56068847
18	TRIM28	1.50965298
19	FLT3	1.46897694
20	ACVR1B	1.44430219
21	TIE1	1.38896435
22	NEK1	1.37187412
23	MKNK2	1.34845872
24	TEC	1.31620776
25	IKBKB	1.30078435
26	PLK3	1.28344190
27	BUB1	1.27376736
28	OXSR1	1.27240854
29	BCKDK	1.25090336
30	TGFBR1	1.18947289
31	PINK1	1.16733460
32	MAP4K1	1.16028528
33	WNK4	1.14640278
34	PDK2	1.11477107
35	STK39	1.09039849
36	FES	1.06745347
37	MAP3K12	1.05805385
38	MKNK1	1.04848040
39	MAP3K13	1.02144601
40	MAP3K14	1.01451609
41	IKBKE	0.98676484
42	TNIK	0.96626529
43	EIF2AK2	0.96226437
44	NLK	0.94393599
45	KIT	0.94081212
46	IRAK1	0.89777599
47	PIK3CG	0.84568206
48	PLK2	0.83738407
49	BMPR2	0.83403320
50	PASK	0.82829166
51	PIK3CA	0.80488273
52	BRSK2	0.79382033
53	ITK	0.78766598
54	MAPK13	0.76528190
55	CSNK1G1	0.75673077
56	PAK3	0.72204296
57	PBK	0.69861570
58	CASK	0.69289313
59	EIF2AK1	0.69150003
60	MAP3K4	0.68533484
61	PRKCQ	0.63196902
62	TAF1	0.60402162
63	CSNK1G3	0.59656229
64	BTK	0.58290167
65	PHKG2	0.58105272
66	PHKG1	0.58105272
67	ATR	0.57880369
68	RPS6KA5	0.57305207
69	NME1	0.57183474
70	CDK8	0.56412717
71	CSNK1G2	0.55997567
72	ADRBK1	0.55823891
73	SYK	0.55324230
74	CDC7	0.53493792
75	ATM	0.51171262
76	INSRR	0.50837013
77	DYRK2	0.50150395
78	STK3	0.49708067
79	PLK4	0.49289864
80	PLK1	0.48603907
81	CHUK	0.47900339
82	STK38L	0.46687605
83	MAP2K6	0.44823593
84	GRK5	0.42978683
85	STK4	0.40705150
86	SRPK1	0.40695930
87	GRK7	0.40495807
88	PRKCE	0.39466589
89	TRPM7	0.38727983
90	LYN	0.38142104
91	LCK	0.36003854
92	CSNK2A2	0.35213270
93	CSNK2A1	0.31986120
94	PRKCG	0.30803135
95	PRKCI	0.30553398
96	CSNK1A1	0.29337448
97	BRD4	0.29149349
98	CSNK1A1L	0.28153904
99	IRAK4	0.27318235
100	CHEK2	0.25799198

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.83932998
2	Ribosome_Homo sapiens_hsa03010	3.07591397
3	Asthma_Homo sapiens_hsa05310	2.78383725
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.49617797
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.37730351
6	Homologous recombination_Homo sapiens_hsa03440	2.30324018
7	Protein export_Homo sapiens_hsa03060	2.28775495
8	Allograft rejection_Homo sapiens_hsa05330	2.25869734
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.17044516
10	Parkinsons disease_Homo sapiens_hsa05012	2.16929115
11	RNA polymerase_Homo sapiens_hsa03020	2.10640667
12	RNA degradation_Homo sapiens_hsa03018	2.08194145
13	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.07864772
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.89766686
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.85560872
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.81204489
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.80022002
18	One carbon pool by folate_Homo sapiens_hsa00670	1.76715731
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.76591009
20	Basal transcription factors_Homo sapiens_hsa03022	1.76408420
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.73284603
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.71228720
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.60624174
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58470909
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.58011272
26	Phototransduction_Homo sapiens_hsa04744	1.51983706
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51701577
28	Propanoate metabolism_Homo sapiens_hsa00640	1.49417178
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.39058210
30	Mismatch repair_Homo sapiens_hsa03430	1.38460713
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.37111745
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.33986821
33	Butanoate metabolism_Homo sapiens_hsa00650	1.31717690
34	Huntingtons disease_Homo sapiens_hsa05016	1.29914335
35	Antigen processing and presentation_Homo sapiens_hsa04612	1.25099326
36	Base excision repair_Homo sapiens_hsa03410	1.22539655
37	RNA transport_Homo sapiens_hsa03013	1.20919799
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19799712
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.19360051
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19187363
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.19004021
42	Alzheimers disease_Homo sapiens_hsa05010	1.12030126
43	Purine metabolism_Homo sapiens_hsa00230	1.08267084
44	Peroxisome_Homo sapiens_hsa04146	1.06638538
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04214837
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00812748
47	Caffeine metabolism_Homo sapiens_hsa00232	1.00706961
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99932826
49	Sulfur relay system_Homo sapiens_hsa04122	0.99438384
50	DNA replication_Homo sapiens_hsa03030	0.98497451
51	Nucleotide excision repair_Homo sapiens_hsa03420	0.97174898
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96088394
53	Spliceosome_Homo sapiens_hsa03040	0.95804909
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95378586
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.93610634
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91242557
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.89983457
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.87161964
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.82265732
60	Retinol metabolism_Homo sapiens_hsa00830	0.81733615
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81672236
62	Regulation of autophagy_Homo sapiens_hsa04140	0.80819689
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78461927
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77303939
65	Rheumatoid arthritis_Homo sapiens_hsa05323	0.77151673
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77134788
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76912298
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74807350
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74275663
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69928255
71	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68668832
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66536098
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60836141
74	Metabolic pathways_Homo sapiens_hsa01100	0.60001303
75	Sulfur metabolism_Homo sapiens_hsa00920	0.59670437
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59034654
77	Olfactory transduction_Homo sapiens_hsa04740	0.58707117
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.58488240
79	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.54406953
80	Cardiac muscle contraction_Homo sapiens_hsa04260	0.53252899
81	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.51874031
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50691652
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48646879
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47653433
85	Fatty acid degradation_Homo sapiens_hsa00071	0.47440452
86	Folate biosynthesis_Homo sapiens_hsa00790	0.47065827
87	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.46241292
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42125730
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.41611562
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40889908
91	Taste transduction_Homo sapiens_hsa04742	0.40878512
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39245723
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.38325107
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37877981
95	Measles_Homo sapiens_hsa05162	0.35020332
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34158197
97	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.33487319
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33140926
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33046516
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.32274669

EEF1A1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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