ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.86244422
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.60543779
3	L-fucose catabolic process (GO:0042355)	4.08840277
4	fucose catabolic process (GO:0019317)	4.08840277
5	L-fucose metabolic process (GO:0042354)	4.08840277
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.98944923
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.98944923
8	behavioral response to nicotine (GO:0035095)	3.87658695
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.80510147
10	preassembly of GPI anchor in ER membrane (GO:0016254)	3.71472699
11	ATP synthesis coupled proton transport (GO:0015986)	3.71160681
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.71160681
13	mannosylation (GO:0097502)	3.62968366
14	rRNA modification (GO:0000154)	3.40555386
15	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.38748164
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.34319011
17	respiratory chain complex IV assembly (GO:0008535)	3.33586025
18	platelet dense granule organization (GO:0060155)	3.30874561
19	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.29851226
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.28446340
21	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.26580051
22	GPI anchor metabolic process (GO:0006505)	3.26082948
23	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.25986393
24	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.25986393
25	isotype switching (GO:0045190)	3.25986393
26	cytidine metabolic process (GO:0046087)	3.25540943
27	cytidine catabolic process (GO:0006216)	3.25540943
28	cytidine deamination (GO:0009972)	3.25540943
29	response to pheromone (GO:0019236)	3.25515666
30	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.25371207
31	branched-chain amino acid catabolic process (GO:0009083)	3.24859044
32	protein neddylation (GO:0045116)	3.14956542
33	cellular ketone body metabolic process (GO:0046950)	3.07715658
34	positive regulation of defense response to virus by host (GO:0002230)	3.00725231
35	amino acid salvage (GO:0043102)	2.99316075
36	L-methionine salvage (GO:0071267)	2.99316075
37	L-methionine biosynthetic process (GO:0071265)	2.99316075
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.96997082
39	rRNA catabolic process (GO:0016075)	2.96386956
40	negative regulation of telomere maintenance (GO:0032205)	2.95566983
41	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.95448996
42	proteasome assembly (GO:0043248)	2.95219892
43	piRNA metabolic process (GO:0034587)	2.94403016
44	regulation of mitotic spindle checkpoint (GO:1903504)	2.93843098
45	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.93843098
46	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.91579395
47	rRNA methylation (GO:0031167)	2.91564759
48	maturation of 5.8S rRNA (GO:0000460)	2.91542775
49	peptidyl-histidine modification (GO:0018202)	2.91180285
50	protein complex biogenesis (GO:0070271)	2.89734461
51	cytochrome complex assembly (GO:0017004)	2.87674747
52	kynurenine metabolic process (GO:0070189)	2.87644500
53	positive regulation of prostaglandin secretion (GO:0032308)	2.86598823
54	GPI anchor biosynthetic process (GO:0006506)	2.84928618
55	cullin deneddylation (GO:0010388)	2.84040755
56	S-adenosylmethionine metabolic process (GO:0046500)	2.83448446
57	pseudouridine synthesis (GO:0001522)	2.81432757
58	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.80621177
59	branched-chain amino acid metabolic process (GO:0009081)	2.80223918
60	protein deneddylation (GO:0000338)	2.79988434
61	ribosomal small subunit assembly (GO:0000028)	2.75207125
62	tRNA processing (GO:0008033)	2.75195224
63	ketone body metabolic process (GO:1902224)	2.74235317
64	mitochondrial respiratory chain complex assembly (GO:0033108)	2.73798152
65	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.73462309
66	cellular response to interleukin-15 (GO:0071350)	2.73185784
67	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.70918657
68	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.70918657
69	NADH dehydrogenase complex assembly (GO:0010257)	2.70918657
70	termination of RNA polymerase III transcription (GO:0006386)	2.69942551
71	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69942551
72	protein-cofactor linkage (GO:0018065)	2.65615432
73	indole-containing compound catabolic process (GO:0042436)	2.65361132
74	indolalkylamine catabolic process (GO:0046218)	2.65361132
75	tryptophan catabolic process (GO:0006569)	2.65361132
76	GTP biosynthetic process (GO:0006183)	2.60196194
77	valine metabolic process (GO:0006573)	2.60180389
78	indolalkylamine metabolic process (GO:0006586)	2.55809510
79	C-terminal protein lipidation (GO:0006501)	2.55799639
80	chaperone-mediated protein transport (GO:0072321)	2.55103499
81	signal peptide processing (GO:0006465)	2.54251636
82	regulation of isotype switching to IgG isotypes (GO:0048302)	2.51084456
83	regulation of cellular amino acid metabolic process (GO:0006521)	2.48340856
84	electron transport chain (GO:0022900)	2.48230475
85	DNA catabolic process, exonucleolytic (GO:0000738)	2.46132849
86	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.46079130
87	somatic diversification of immunoglobulins (GO:0016445)	2.45680137
88	maturation of SSU-rRNA (GO:0030490)	2.45476380
89	negative regulation of mast cell activation (GO:0033004)	2.45450058
90	tRNA modification (GO:0006400)	2.44161786
91	respiratory electron transport chain (GO:0022904)	2.41922415
92	tRNA metabolic process (GO:0006399)	2.41820020
93	regulation of immunoglobulin secretion (GO:0051023)	2.41061440
94	C-terminal protein amino acid modification (GO:0018410)	2.40782280
95	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.39982929
96	regulation of regulatory T cell differentiation (GO:0045589)	2.39583343
97	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.39546952
98	cellular response to ATP (GO:0071318)	2.38498443
99	DNA double-strand break processing (GO:0000729)	2.38329643
100	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.37882381

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.03334780
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.95642419
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.31420665
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16256352
5	VDR_22108803_ChIP-Seq_LS180_Human	3.10845668
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10535084
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82051050
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.71480696
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.50535788
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.50033488
11	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.49501746
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.46585799
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24565771
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.18582977
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.14127250
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.12235662
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.12041548
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.11938976
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.11248257
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.10173493
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08312740
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95644902
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.94429874
24	EWS_26573619_Chip-Seq_HEK293_Human	1.91401159
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.85299767
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.84602196
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.81457437
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.79298941
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.73869159
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.67421474
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.67289377
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.64761303
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.61381544
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57899255
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.55086249
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53246494
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.52479796
38	FUS_26573619_Chip-Seq_HEK293_Human	1.48130276
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.47605986
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44193639
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43966492
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43966492
43	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.43725715
44	GATA3_26560356_Chip-Seq_TH2_Human	1.42143406
45	P300_19829295_ChIP-Seq_ESCs_Human	1.42127598
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38871604
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.38169281
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.37503711
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.37129567
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36518295
51	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.35152014
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.29949409
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29895475
54	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.29439060
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.28935349
56	AR_20517297_ChIP-Seq_VCAP_Human	1.28681665
57	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.28364832
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.26787791
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26787791
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.25894061
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23790657
62	GBX2_23144817_ChIP-Seq_PC3_Human	1.23323043
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22033730
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22033730
65	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.19918573
66	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.19600323
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19228680
68	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.18973204
69	TAF15_26573619_Chip-Seq_HEK293_Human	1.17390515
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.17386987
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16713664
72	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.16382694
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.15871604
74	NCOR_22424771_ChIP-Seq_293T_Human	1.15793835
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.10246288
76	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07823097
77	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05761387
78	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.04322724
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03396162
80	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01204763
81	GABP_19822575_ChIP-Seq_HepG2_Human	1.01132250
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00711888
83	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97950398
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97131896
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.96419312
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95576295
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95292077
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.92096287
89	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.92034202
90	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91938177
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.91436086
92	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90806988
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.90721486
94	TTF2_22483619_ChIP-Seq_HELA_Human	0.89881281
95	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89705417
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.89637274
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88744306
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.88731855
99	MYB_26560356_Chip-Seq_TH2_Human	0.88243128
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88038622

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.07639512
2	MP0000372_irregular_coat_pigmentation	3.04619246
3	MP0005671_abnormal_response_to	3.00274004
4	MP0008877_abnormal_DNA_methylation	2.90018813
5	MP0006072_abnormal_retinal_apoptosis	2.78906271
6	MP0001835_abnormal_antigen_presentation	2.56160313
7	MP0002102_abnormal_ear_morphology	2.49871035
8	MP0004147_increased_porphyrin_level	2.49339085
9	MP0002138_abnormal_hepatobiliary_system	2.43603045
10	MP0005075_abnormal_melanosome_morpholog	2.39363642
11	MP0008872_abnormal_physiological_respon	2.32822580
12	MP0001968_abnormal_touch/_nociception	2.17443293
13	MP0002736_abnormal_nociception_after	2.12206570
14	MP0008875_abnormal_xenobiotic_pharmacok	2.04607399
15	MP0005084_abnormal_gallbladder_morpholo	1.93498983
16	MP0004885_abnormal_endolymph	1.91367466
17	MP0003786_premature_aging	1.87902951
18	MP0002837_dystrophic_cardiac_calcinosis	1.84854991
19	MP0003195_calcinosis	1.81480555
20	MP0000569_abnormal_digit_pigmentation	1.80131173
21	MP0005551_abnormal_eye_electrophysiolog	1.79970213
22	MP0008058_abnormal_DNA_repair	1.75535772
23	MP0005646_abnormal_pituitary_gland	1.67969941
24	MP0002876_abnormal_thyroid_physiology	1.66365068
25	MP0005174_abnormal_tail_pigmentation	1.59262734
26	MP0001986_abnormal_taste_sensitivity	1.57594477
27	MP0005645_abnormal_hypothalamus_physiol	1.56219237
28	MP0000685_abnormal_immune_system	1.55362634
29	MP0002938_white_spotting	1.52628626
30	MP0002163_abnormal_gland_morphology	1.51732775
31	MP0002148_abnormal_hypersensitivity_rea	1.47963434
32	MP0001800_abnormal_humoral_immune	1.44942931
33	MP0005253_abnormal_eye_physiology	1.37761277
34	MP0003724_increased_susceptibility_to	1.37448971
35	MP0003718_maternal_effect	1.34923551
36	MP0003806_abnormal_nucleotide_metabolis	1.33747397
37	MP0003646_muscle_fatigue	1.32692568
38	MP0009785_altered_susceptibility_to	1.30649117
39	MP0004145_abnormal_muscle_electrophysio	1.29868304
40	MP0002006_tumorigenesis	1.28934690
41	MP0005000_abnormal_immune_tolerance	1.25752276
42	MP0004142_abnormal_muscle_tone	1.22644157
43	MP0002166_altered_tumor_susceptibility	1.22066906
44	MP0003866_abnormal_defecation	1.20462712
45	MP0006036_abnormal_mitochondrial_physio	1.19369868
46	MP0005167_abnormal_blood-brain_barrier	1.18307549
47	MP0002234_abnormal_pharynx_morphology	1.16938255
48	MP0003011_delayed_dark_adaptation	1.16288354
49	MP0001501_abnormal_sleep_pattern	1.14709276
50	MP0003787_abnormal_imprinting	1.14046489
51	MP0005389_reproductive_system_phenotype	1.13773609
52	MP0002723_abnormal_immune_serum	1.12956828
53	MP0005379_endocrine/exocrine_gland_phen	1.12229135
54	MP0003880_abnormal_central_pattern	1.09518403
55	MP0008995_early_reproductive_senescence	1.04641917
56	MP0008789_abnormal_olfactory_epithelium	1.04163562
57	MP0005387_immune_system_phenotype	1.03785866
58	MP0001790_abnormal_immune_system	1.03785866
59	MP0005332_abnormal_amino_acid	1.03099362
60	MP0001919_abnormal_reproductive_system	1.01476806
61	MP0006035_abnormal_mitochondrial_morpho	1.01245522
62	MP0002277_abnormal_respiratory_mucosa	0.99311314
63	MP0009764_decreased_sensitivity_to	0.98827515
64	MP0002452_abnormal_antigen_presenting	0.98730084
65	MP0005636_abnormal_mineral_homeostasis	0.98707579
66	MP0001529_abnormal_vocalization	0.98673453
67	MP0002638_abnormal_pupillary_reflex	0.98498044
68	MP0002420_abnormal_adaptive_immunity	0.97754620
69	MP0001819_abnormal_immune_cell	0.97680929
70	MP0005410_abnormal_fertilization	0.95919523
71	MP0003252_abnormal_bile_duct	0.95392129
72	MP0001764_abnormal_homeostasis	0.93774499
73	MP0005377_hearing/vestibular/ear_phenot	0.92464431
74	MP0003878_abnormal_ear_physiology	0.92464431
75	MP0006276_abnormal_autonomic_nervous	0.91874970
76	MP0001905_abnormal_dopamine_level	0.91306097
77	MP0003763_abnormal_thymus_physiology	0.90640075
78	MP0003186_abnormal_redox_activity	0.90246359
79	MP0005085_abnormal_gallbladder_physiolo	0.89826212
80	MP0002272_abnormal_nervous_system	0.89614603
81	MP0010386_abnormal_urinary_bladder	0.86246278
82	MP0009745_abnormal_behavioral_response	0.85758678
83	MP0009333_abnormal_splenocyte_physiolog	0.85695509
84	MP0004381_abnormal_hair_follicle	0.85627748
85	MP0000427_abnormal_hair_cycle	0.83470480
86	MP0001873_stomach_inflammation	0.82351059
87	MP0010155_abnormal_intestine_physiology	0.82118779
88	MP0008775_abnormal_heart_ventricle	0.79977690
89	MP0004742_abnormal_vestibular_system	0.79838914
90	MP0000631_abnormal_neuroendocrine_gland	0.79554734
91	MP0003693_abnormal_embryo_hatching	0.79484544
92	MP0000689_abnormal_spleen_morphology	0.78899371
93	MP0001661_extended_life_span	0.76065151
94	MP0001845_abnormal_inflammatory_respons	0.75266670
95	MP0002160_abnormal_reproductive_system	0.74438970
96	MP0000613_abnormal_salivary_gland	0.73389781
97	MP0003638_abnormal_response/metabolism_	0.73154321
98	MP0002095_abnormal_skin_pigmentation	0.72872107
99	MP0001984_abnormal_olfaction	0.69780316
100	MP0002693_abnormal_pancreas_physiology	0.68471030

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	3.74619832
2	Pancreatic cysts (HP:0001737)	3.58139066
3	Methylmalonic acidemia (HP:0002912)	3.32381351
4	3-Methylglutaconic aciduria (HP:0003535)	3.31367136
5	Pancreatic fibrosis (HP:0100732)	3.19182259
6	Stomatitis (HP:0010280)	3.14459998
7	Acute necrotizing encephalopathy (HP:0006965)	3.13820218
8	Abnormality of the renal cortex (HP:0011035)	3.07038560
9	Congenital, generalized hypertrichosis (HP:0004540)	3.06236513
10	Increased CSF lactate (HP:0002490)	3.04601574
11	Type II lissencephaly (HP:0007260)	3.04537700
12	Abolished electroretinogram (ERG) (HP:0000550)	3.01956884
13	Mitochondrial inheritance (HP:0001427)	3.01666841
14	Abnormality of midbrain morphology (HP:0002418)	2.97302474
15	Molar tooth sign on MRI (HP:0002419)	2.97302474
16	Nephronophthisis (HP:0000090)	2.90357927
17	Acute encephalopathy (HP:0006846)	2.89792883
18	Renal cortical cysts (HP:0000803)	2.87655462
19	True hermaphroditism (HP:0010459)	2.86618955
20	Congenital stationary night blindness (HP:0007642)	2.85951931
21	Methylmalonic aciduria (HP:0012120)	2.84341810
22	Attenuation of retinal blood vessels (HP:0007843)	2.81271443
23	Progressive macrocephaly (HP:0004481)	2.77147002
24	Pendular nystagmus (HP:0012043)	2.75113299
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.67143435
26	Hepatocellular necrosis (HP:0001404)	2.66629528
27	Elevated erythrocyte sedimentation rate (HP:0003565)	2.64219639
28	Hepatic necrosis (HP:0002605)	2.59376154
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.55830123
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.49992392
31	Abnormality of alanine metabolism (HP:0010916)	2.49992392
32	Hyperalaninemia (HP:0003348)	2.49992392
33	Abnormality of the renal medulla (HP:0100957)	2.49363833
34	Increased serum lactate (HP:0002151)	2.48172479
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.46996292
36	Lipid accumulation in hepatocytes (HP:0006561)	2.41485814
37	Keratoconus (HP:0000563)	2.40114549
38	Increased corneal curvature (HP:0100692)	2.40114549
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.39559606
40	Increased hepatocellular lipid droplets (HP:0006565)	2.39419042
41	Severe combined immunodeficiency (HP:0004430)	2.37073698
42	Thyroiditis (HP:0100646)	2.36706672
43	Hypoproteinemia (HP:0003075)	2.33735807
44	Abnormality of the pons (HP:0007361)	2.33453597
45	Optic disc pallor (HP:0000543)	2.32206308
46	Medial flaring of the eyebrow (HP:0010747)	2.26306380
47	Hypoplasia of the pons (HP:0012110)	2.23730229
48	Abnormality of the prostate (HP:0008775)	2.23030414
49	Type 2 muscle fiber atrophy (HP:0003554)	2.19609187
50	Abnormal biliary tract physiology (HP:0012439)	2.16545998
51	Bile duct proliferation (HP:0001408)	2.16545998
52	Cerebral edema (HP:0002181)	2.16313561
53	Short tibia (HP:0005736)	2.13030573
54	Lactic acidosis (HP:0003128)	2.10981251
55	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.10139146
56	Aplasia/hypoplasia of the uterus (HP:0008684)	2.09519195
57	Progressive microcephaly (HP:0000253)	2.08250116
58	Decreased central vision (HP:0007663)	2.02910333
59	Chronic hepatic failure (HP:0100626)	2.02033263
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01997592
61	Lethargy (HP:0001254)	1.99210566
62	Abnormality of B cell number (HP:0010975)	1.98082506
63	Hypoplasia of the uterus (HP:0000013)	1.97798821
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.97569593
65	Prostate neoplasm (HP:0100787)	1.96470664
66	Hypothermia (HP:0002045)	1.96071732
67	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.96010641
68	Abnormality of vitamin B metabolism (HP:0004340)	1.94165245
69	Abnormality of T cells (HP:0002843)	1.91234811
70	Dicarboxylic aciduria (HP:0003215)	1.89297967
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.89297967
72	Cystic liver disease (HP:0006706)	1.89182966
73	Polydipsia (HP:0001959)	1.88256260
74	Abnormal drinking behavior (HP:0030082)	1.88256260
75	Stomach cancer (HP:0012126)	1.86527036
76	Type I transferrin isoform profile (HP:0003642)	1.86495815
77	Cerebellar dysplasia (HP:0007033)	1.85747602
78	Asplenia (HP:0001746)	1.85508624
79	Abnormality of eosinophils (HP:0001879)	1.85371683
80	Hyperglycinuria (HP:0003108)	1.84549362
81	Retinal dysplasia (HP:0007973)	1.82462788
82	Abnormality of serum amino acid levels (HP:0003112)	1.81330071
83	Abnormality of T cell physiology (HP:0011840)	1.80522610
84	Postaxial foot polydactyly (HP:0001830)	1.80479723
85	Conical tooth (HP:0000698)	1.80335743
86	Absent thumb (HP:0009777)	1.79942763
87	Tubular atrophy (HP:0000092)	1.79009632
88	Hypomagnesemia (HP:0002917)	1.77891435
89	Abnormal number of erythroid precursors (HP:0012131)	1.77552825
90	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77160297
91	Abnormal protein glycosylation (HP:0012346)	1.77056973
92	Abnormal glycosylation (HP:0012345)	1.77056973
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.77056973
94	Abnormal protein N-linked glycosylation (HP:0012347)	1.77056973
95	Abnormality of the ileum (HP:0001549)	1.76045239
96	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.75736057
97	Polyuria (HP:0000103)	1.75520526
98	T lymphocytopenia (HP:0005403)	1.74125238
99	Abnormality of glycine metabolism (HP:0010895)	1.74079596
100	Abnormality of serine family amino acid metabolism (HP:0010894)	1.74079596

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.72604517
2	TAOK3	3.54211802
3	FRK	3.14277196
4	TLK1	3.04108240
5	ZAK	3.02734642
6	NUAK1	2.93219771
7	ADRBK2	2.91427743
8	TXK	2.81508530
9	GRK1	2.63593835
10	BCKDK	2.41232921
11	EIF2AK3	2.31886375
12	VRK2	2.23379683
13	WNK4	1.70500670
14	MST4	1.68630406
15	PINK1	1.65182945
16	WNK3	1.59858865
17	MAP4K1	1.44053829
18	STK16	1.39982918
19	BMPR1B	1.38529979
20	TIE1	1.38397153
21	VRK1	1.36369609
22	TRIM28	1.29772431
23	TEC	1.27834533
24	KIT	1.18844838
25	OXSR1	1.15546572
26	ACVR1B	1.15129955
27	BUB1	1.15118185
28	GRK6	1.14774341
29	IKBKB	1.14048753
30	BMPR2	1.08131090
31	PASK	1.05201954
32	PHKG2	1.04152561
33	PHKG1	1.04152561
34	ITK	1.03898713
35	KDR	0.97979205
36	STK39	0.95315297
37	FES	0.94631860
38	MAP3K14	0.93591012
39	NEK1	0.93551088
40	INSRR	0.92551553
41	PLK3	0.91519831
42	EIF2AK1	0.91504377
43	PLK4	0.90062438
44	SRPK1	0.87617585
45	TSSK6	0.87057108
46	PLK2	0.86794768
47	MKNK1	0.86227506
48	EIF2AK2	0.81422559
49	CAMKK2	0.81042174
50	DAPK2	0.81031524
51	ERBB3	0.80843250
52	SYK	0.79424742
53	ADRBK1	0.77794517
54	MAP3K4	0.74677850
55	PIK3CG	0.74216623
56	RPS6KA5	0.72733066
57	DYRK2	0.72084917
58	MAP2K2	0.69002264
59	TGFBR1	0.68232846
60	CDK8	0.67363655
61	PRKCE	0.67041861
62	PRKCQ	0.65993198
63	FLT3	0.65640751
64	MAPKAPK3	0.64760908
65	MAPK13	0.64580716
66	GRK5	0.64478826
67	RPS6KA4	0.62749866
68	NME1	0.62138517
69	GRK7	0.61345901
70	IKBKE	0.60778715
71	CSNK1G3	0.59135343
72	MAP2K6	0.59072065
73	DAPK1	0.56349184
74	MKNK2	0.55970353
75	CDK19	0.53952276
76	CSNK1G1	0.52535834
77	LCK	0.52486786
78	ATR	0.51450258
79	CSNK1G2	0.49817699
80	MUSK	0.48643396
81	LYN	0.48259169
82	BTK	0.45641589
83	TNIK	0.45121675
84	TNK2	0.44547355
85	BRSK2	0.44507335
86	CSF1R	0.43906004
87	PRKCG	0.41808522
88	CSNK1A1L	0.41481833
89	CSNK1A1	0.40307611
90	MAPKAPK5	0.40188458
91	NLK	0.39917791
92	JAK3	0.39057067
93	IGF1R	0.36616540
94	PLK1	0.35729330
95	TBK1	0.34085363
96	OBSCN	0.33960396
97	CSNK2A1	0.33080899
98	MAP2K7	0.32743424
99	BCR	0.32675470
100	MYLK	0.31062124

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.23514306
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.99540897
3	Proteasome_Homo sapiens_hsa03050	2.96770712
4	Allograft rejection_Homo sapiens_hsa05330	2.73734050
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.61810730
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52418965
7	Protein export_Homo sapiens_hsa03060	2.50418817
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.48018725
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.30358474
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.23588597
11	RNA polymerase_Homo sapiens_hsa03020	2.10025153
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.06967630
13	Parkinsons disease_Homo sapiens_hsa05012	1.98878527
14	Ribosome_Homo sapiens_hsa03010	1.94978694
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94434972
16	Homologous recombination_Homo sapiens_hsa03440	1.83044187
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.82377233
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.79750958
19	Phototransduction_Homo sapiens_hsa04744	1.75950228
20	RNA degradation_Homo sapiens_hsa03018	1.75323002
21	Propanoate metabolism_Homo sapiens_hsa00640	1.70943455
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.68239015
23	Basal transcription factors_Homo sapiens_hsa03022	1.64470811
24	One carbon pool by folate_Homo sapiens_hsa00670	1.57976493
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45328073
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.45060192
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43116006
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.30330627
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29225900
30	Butanoate metabolism_Homo sapiens_hsa00650	1.28397944
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27445341
32	Sulfur metabolism_Homo sapiens_hsa00920	1.26556346
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.23931919
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21801793
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.19719884
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.18981098
37	Alzheimers disease_Homo sapiens_hsa05010	1.16295719
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.15746879
39	Huntingtons disease_Homo sapiens_hsa05016	1.15619937
40	Rheumatoid arthritis_Homo sapiens_hsa05323	1.14728211
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.13615160
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.11918210
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.11806035
44	Peroxisome_Homo sapiens_hsa04146	1.10559732
45	Regulation of autophagy_Homo sapiens_hsa04140	1.06945089
46	Mismatch repair_Homo sapiens_hsa03430	1.01342552
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.01176378
48	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.96857156
49	RNA transport_Homo sapiens_hsa03013	0.95448293
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.95116862
51	Purine metabolism_Homo sapiens_hsa00230	0.94948228
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.94608919
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89966265
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.89004609
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88215821
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.87675151
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.87438804
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83951237
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82588889
60	Spliceosome_Homo sapiens_hsa03040	0.81778761
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.81760628
62	Caffeine metabolism_Homo sapiens_hsa00232	0.81120722
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79518838
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78340487
65	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77512814
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76795448
67	DNA replication_Homo sapiens_hsa03030	0.76657976
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74232938
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67018661
70	Fatty acid elongation_Homo sapiens_hsa00062	0.66886675
71	Base excision repair_Homo sapiens_hsa03410	0.66635770
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66137648
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66067102
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65855213
75	Retinol metabolism_Homo sapiens_hsa00830	0.65519012
76	Viral myocarditis_Homo sapiens_hsa05416	0.63698456
77	Metabolic pathways_Homo sapiens_hsa01100	0.60624179
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56484664
79	Fat digestion and absorption_Homo sapiens_hsa04975	0.55898371
80	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53208127
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51762308
82	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.50881170
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50369031
84	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48247410
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46976724
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.46463795
87	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45996027
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45205887
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43412348
90	Fatty acid degradation_Homo sapiens_hsa00071	0.42114229
91	Olfactory transduction_Homo sapiens_hsa04740	0.40907210
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.39166665
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.38800916
94	Glutathione metabolism_Homo sapiens_hsa00480	0.35646114
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34638233
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.33593804
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32494889
98	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.32433022
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30038224
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.29447631

EEF1A1P30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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