ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	proteasome assembly (GO:0043248)	6.42104523
2	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	5.85166763
3	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	5.35307856
4	pyrimidine nucleobase catabolic process (GO:0006208)	5.16668138
5	nucleobase catabolic process (GO:0046113)	4.50467565
6	limb bud formation (GO:0060174)	4.48079271
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.22084218
8	retinal rod cell development (GO:0046548)	4.19698377
9	regulation of immunoglobulin secretion (GO:0051023)	3.90985972
10	rRNA modification (GO:0000154)	3.85882726
11	DNA deamination (GO:0045006)	3.81871830
12	pseudouridine synthesis (GO:0001522)	3.79491178
13	neural tube formation (GO:0001841)	3.72520686
14	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.67835780
15	UMP metabolic process (GO:0046049)	3.67835780
16	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.67835780
17	UMP biosynthetic process (GO:0006222)	3.67835780
18	piRNA metabolic process (GO:0034587)	3.56196668
19	rRNA methylation (GO:0031167)	3.55869669
20	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.48842586
21	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.47741368
22	positive regulation of amino acid transport (GO:0051957)	3.40743791
23	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.40010584
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.35983899
25	NADH dehydrogenase complex assembly (GO:0010257)	3.35983899
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.35983899
27	regulation of chronic inflammatory response (GO:0002676)	3.29506203
28	regulation of DNA endoreduplication (GO:0032875)	3.27476671
29	rRNA catabolic process (GO:0016075)	3.21182596
30	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.20006630
31	DNA double-strand break processing (GO:0000729)	3.13117085
32	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13001520
33	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.09736367
34	GTP biosynthetic process (GO:0006183)	3.03313249
35	indolalkylamine metabolic process (GO:0006586)	3.01013371
36	protein complex biogenesis (GO:0070271)	2.96608021
37	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.96187644
38	histone mRNA metabolic process (GO:0008334)	2.94922232
39	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.93491964
40	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91452479
41	protein polyglutamylation (GO:0018095)	2.90887547
42	L-fucose catabolic process (GO:0042355)	2.90241715
43	fucose catabolic process (GO:0019317)	2.90241715
44	L-fucose metabolic process (GO:0042354)	2.90241715
45	cellular response to interleukin-15 (GO:0071350)	2.89994423
46	ketone body metabolic process (GO:1902224)	2.88968344
47	melanin metabolic process (GO:0006582)	2.88854945
48	regulation of regulatory T cell differentiation (GO:0045589)	2.88251247
49	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.83974865
50	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.78018008
51	sialylation (GO:0097503)	2.77388861
52	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.76736095
53	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.76500505
54	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.75654628
55	melanin biosynthetic process (GO:0042438)	2.75087557
56	respiratory chain complex IV assembly (GO:0008535)	2.74858763
57	ribosome biogenesis (GO:0042254)	2.74383272
58	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.74135184
59	regulation of mitotic spindle checkpoint (GO:1903504)	2.74135184
60	maturation of 5.8S rRNA (GO:0000460)	2.72226522
61	tRNA aminoacylation (GO:0043039)	2.72149481
62	amino acid activation (GO:0043038)	2.72149481
63	negative regulation of mast cell activation (GO:0033004)	2.71810079
64	kynurenine metabolic process (GO:0070189)	2.71753750
65	secondary metabolite biosynthetic process (GO:0044550)	2.71673578
66	positive regulation of vesicle fusion (GO:0031340)	2.71250870
67	cellular ketone body metabolic process (GO:0046950)	2.69160164
68	tRNA processing (GO:0008033)	2.68184000
69	positive regulation of defense response to virus by host (GO:0002230)	2.68100829
70	response to pheromone (GO:0019236)	2.67754938
71	tRNA metabolic process (GO:0006399)	2.64679607
72	regulation of cilium movement (GO:0003352)	2.62780950
73	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.61566261
74	isotype switching (GO:0045190)	2.61566261
75	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.61566261
76	signal peptide processing (GO:0006465)	2.61259451
77	regulation of feeding behavior (GO:0060259)	2.61035607
78	regulation of isotype switching to IgG isotypes (GO:0048302)	2.60707380
79	regulation of hippo signaling (GO:0035330)	2.59977234
80	positive regulation of DNA recombination (GO:0045911)	2.57344382
81	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.56503935
82	UTP biosynthetic process (GO:0006228)	2.53785296
83	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.50787822
84	DNA methylation involved in gamete generation (GO:0043046)	2.50715800
85	termination of RNA polymerase I transcription (GO:0006363)	2.50575682
86	negative regulation of T cell differentiation in thymus (GO:0033085)	2.47604463
87	early endosome to late endosome transport (GO:0045022)	2.46432646
88	cornea development in camera-type eye (GO:0061303)	2.44616723
89	ribosomal large subunit biogenesis (GO:0042273)	2.43922824
90	tRNA aminoacylation for protein translation (GO:0006418)	2.41804658
91	rRNA metabolic process (GO:0016072)	2.41335256
92	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.40372368
93	CTP biosynthetic process (GO:0006241)	2.39822524
94	CTP metabolic process (GO:0046036)	2.39822524
95	protein prenylation (GO:0018342)	2.39625429
96	prenylation (GO:0097354)	2.39625429
97	mannosylation (GO:0097502)	2.39317703
98	UTP metabolic process (GO:0046051)	2.38424125
99	cytochrome complex assembly (GO:0017004)	2.37921890
100	male meiosis (GO:0007140)	2.37568862

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.79320940
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.67277328
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23127451
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.04266700
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.01932036
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.59708178
7	FUS_26573619_Chip-Seq_HEK293_Human	2.58474575
8	VDR_22108803_ChIP-Seq_LS180_Human	2.53145917
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.53143793
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.39874388
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.37689502
12	EWS_26573619_Chip-Seq_HEK293_Human	2.32863518
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.26488505
14	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.19527836
15	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.15653186
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10126396
17	GBX2_23144817_ChIP-Seq_PC3_Human	2.09298894
18	P300_19829295_ChIP-Seq_ESCs_Human	2.08968967
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07360237
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99049902
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.93487646
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.89713071
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.89448473
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.87645750
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.82944040
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.82266102
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.75816067
28	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.71166278
29	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70477540
30	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.63284249
31	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.59666390
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53839628
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52817251
34	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.52782307
35	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.52057185
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.49024074
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48603948
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.47228604
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.47096896
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47096896
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46447176
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44440736
43	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.40936641
44	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.40630265
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.38673460
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35980825
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.35720466
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35421117
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35421117
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.29737995
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29496690
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28705908
53	AR_20517297_ChIP-Seq_VCAP_Human	1.27996173
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26474056
55	STAT3_23295773_ChIP-Seq_U87_Human	1.26419955
56	TCF4_23295773_ChIP-Seq_U87_Human	1.25419941
57	TCF4_22108803_ChIP-Seq_LS180_Human	1.25109262
58	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23966019
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23480301
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21400735
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21306589
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20502949
63	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.17578621
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.17076994
65	GATA3_26560356_Chip-Seq_TH2_Human	1.16638385
66	BCAT_22108803_ChIP-Seq_LS180_Human	1.16412748
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.14718584
68	NCOR_22424771_ChIP-Seq_293T_Human	1.14701514
69	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.14504206
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13664057
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12462247
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12462247
73	IRF1_19129219_ChIP-ChIP_H3396_Human	1.12438162
74	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11385338
75	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.09739933
76	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.08133011
77	FOXP3_21729870_ChIP-Seq_TREG_Human	1.06979686
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06556120
79	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06285457
80	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.05937423
81	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04895300
82	CDX2_22108803_ChIP-Seq_LS180_Human	1.04508388
83	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03456034
84	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.03029564
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02345308
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02158871
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01838355
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01693432
89	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00274259
90	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00083751
91	AR_21572438_ChIP-Seq_LNCaP_Human	0.99620733
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99522501
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99500025
94	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99311915
95	AR_25329375_ChIP-Seq_VCAP_Human	0.99015435
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98449774
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.98216260
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.97892617
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96944685
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96680691

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005075_abnormal_melanosome_morpholog	4.08928688
2	MP0000372_irregular_coat_pigmentation	4.08705497
3	MP0002102_abnormal_ear_morphology	3.27137400
4	MP0002822_catalepsy	3.14221466
5	MP0000569_abnormal_digit_pigmentation	3.01496916
6	MP0001835_abnormal_antigen_presentation	2.84394098
7	MP0002837_dystrophic_cardiac_calcinosis	2.67802821
8	MP0003195_calcinosis	2.62110921
9	MP0003646_muscle_fatigue	2.61785819
10	MP0006072_abnormal_retinal_apoptosis	2.54021097
11	MP0005408_hypopigmentation	2.49766181
12	MP0002254_reproductive_system_inflammat	2.49403538
13	MP0002138_abnormal_hepatobiliary_system	2.16529865
14	MP0003806_abnormal_nucleotide_metabolis	2.15529580
15	MP0003718_maternal_effect	2.13942125
16	MP0008877_abnormal_DNA_methylation	2.11432150
17	MP0005253_abnormal_eye_physiology	1.98854299
18	MP0000371_diluted_coat_color	1.98609465
19	MP0008872_abnormal_physiological_respon	1.89629315
20	MP0001529_abnormal_vocalization	1.89513861
21	MP0000685_abnormal_immune_system	1.88665562
22	MP0001968_abnormal_touch/_nociception	1.85418991
23	MP0001501_abnormal_sleep_pattern	1.80982996
24	MP0004381_abnormal_hair_follicle	1.80035946
25	MP0004142_abnormal_muscle_tone	1.79232821
26	MP0003950_abnormal_plasma_membrane	1.71099717
27	MP0002736_abnormal_nociception_after	1.70763282
28	MP0005551_abnormal_eye_electrophysiolog	1.66696039
29	MP0004145_abnormal_muscle_electrophysio	1.66103298
30	MP0003880_abnormal_central_pattern	1.65458001
31	MP0005174_abnormal_tail_pigmentation	1.57279173
32	MP0000383_abnormal_hair_follicle	1.57132519
33	MP0003567_abnormal_fetal_cardiomyocyte	1.46980808
34	MP0005645_abnormal_hypothalamus_physiol	1.46568325
35	MP0005671_abnormal_response_to	1.43953727
36	MP0004885_abnormal_endolymph	1.36412031
37	MP0000427_abnormal_hair_cycle	1.33677627
38	MP0002751_abnormal_autonomic_nervous	1.30760504
39	MP0008058_abnormal_DNA_repair	1.30748275
40	MP0002095_abnormal_skin_pigmentation	1.29287569
41	MP0000516_abnormal_urinary_system	1.29071637
42	MP0005367_renal/urinary_system_phenotyp	1.29071637
43	MP0006036_abnormal_mitochondrial_physio	1.28940447
44	MP0008875_abnormal_xenobiotic_pharmacok	1.28658425
45	MP0002735_abnormal_chemical_nociception	1.27525963
46	MP0000604_amyloidosis	1.24602694
47	MP0005646_abnormal_pituitary_gland	1.24447051
48	MP0009697_abnormal_copulation	1.21185163
49	MP0002166_altered_tumor_susceptibility	1.20586974
50	MP0003011_delayed_dark_adaptation	1.13181630
51	MP0002148_abnormal_hypersensitivity_rea	1.11161994
52	MP0000647_abnormal_sebaceous_gland	1.10883120
53	MP0000015_abnormal_ear_pigmentation	1.10785945
54	MP0001764_abnormal_homeostasis	1.09048623
55	MP0005386_behavior/neurological_phenoty	1.06546360
56	MP0004924_abnormal_behavior	1.06546360
57	MP0009046_muscle_twitch	1.05599651
58	MP0002876_abnormal_thyroid_physiology	1.03964384
59	MP0002909_abnormal_adrenal_gland	1.01713670
60	MP0003786_premature_aging	0.98143219
61	MP0002075_abnormal_coat/hair_pigmentati	0.96292406
62	MP0005379_endocrine/exocrine_gland_phen	0.95106684
63	MP0005387_immune_system_phenotype	0.94884010
64	MP0001790_abnormal_immune_system	0.94884010
65	MP0001873_stomach_inflammation	0.93078162
66	MP0001919_abnormal_reproductive_system	0.93051109
67	MP0008775_abnormal_heart_ventricle	0.92317797
68	MP0006276_abnormal_autonomic_nervous	0.91920435
69	MP0002006_tumorigenesis	0.90431530
70	MP0005389_reproductive_system_phenotype	0.85130928
71	MP0004742_abnormal_vestibular_system	0.84593140
72	MP0001486_abnormal_startle_reflex	0.84099073
73	MP0001984_abnormal_olfaction	0.83906990
74	MP0005332_abnormal_amino_acid	0.80182021
75	MP0003693_abnormal_embryo_hatching	0.80111643
76	MP0005395_other_phenotype	0.79321809
77	MP0000631_abnormal_neuroendocrine_gland	0.78665179
78	MP0001324_abnormal_eye_pigmentation	0.78636738
79	MP0009745_abnormal_behavioral_response	0.78045198
80	MP0005670_abnormal_white_adipose	0.77436955
81	MP0003763_abnormal_thymus_physiology	0.77176326
82	MP0002733_abnormal_thermal_nociception	0.74267240
83	MP0006292_abnormal_olfactory_placode	0.73769958
84	MP0005636_abnormal_mineral_homeostasis	0.68539142
85	MP0001800_abnormal_humoral_immune	0.67302016
86	MP0002067_abnormal_sensory_capabilities	0.66589025
87	MP0006035_abnormal_mitochondrial_morpho	0.66377682
88	MP0003137_abnormal_impulse_conducting	0.65514431
89	MP0010386_abnormal_urinary_bladder	0.64144048
90	MP0005410_abnormal_fertilization	0.63047092
91	MP0004043_abnormal_pH_regulation	0.62984626
92	MP0002229_neurodegeneration	0.62974727
93	MP0001970_abnormal_pain_threshold	0.62317935
94	MP0005310_abnormal_salivary_gland	0.62233152
95	MP0001929_abnormal_gametogenesis	0.61780339
96	MP0002210_abnormal_sex_determination	0.59869671
97	MP0010678_abnormal_skin_adnexa	0.58676462
98	MP0005377_hearing/vestibular/ear_phenot	0.57967970
99	MP0003878_abnormal_ear_physiology	0.57967970
100	MP0002272_abnormal_nervous_system	0.57230443

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	5.52174678
2	Stomatitis (HP:0010280)	5.03375813
3	Abnormality of pyrimidine metabolism (HP:0004353)	4.19492455
4	Pancreatic cysts (HP:0001737)	3.52130092
5	Decreased central vision (HP:0007663)	3.44226567
6	Nephronophthisis (HP:0000090)	3.36319371
7	Type 2 muscle fiber atrophy (HP:0003554)	3.00608151
8	Hyperventilation (HP:0002883)	3.00187784
9	Molar tooth sign on MRI (HP:0002419)	2.94830140
10	Abnormality of midbrain morphology (HP:0002418)	2.94830140
11	Abnormality of the labia minora (HP:0012880)	2.90283485
12	Abnormal biliary tract physiology (HP:0012439)	2.78544135
13	Bile duct proliferation (HP:0001408)	2.78544135
14	Acute necrotizing encephalopathy (HP:0006965)	2.76157652
15	Gaze-evoked nystagmus (HP:0000640)	2.71779900
16	Inability to walk (HP:0002540)	2.70340699
17	Abnormality of the renal medulla (HP:0100957)	2.70099211
18	Acute encephalopathy (HP:0006846)	2.69743680
19	Pancreatic fibrosis (HP:0100732)	2.68239135
20	Intestinal atresia (HP:0011100)	2.64813051
21	Delayed CNS myelination (HP:0002188)	2.56867465
22	Duplicated collecting system (HP:0000081)	2.53956700
23	Increased CSF lactate (HP:0002490)	2.46750513
24	Progressive macrocephaly (HP:0004481)	2.46284946
25	Short phalanx of the thumb (HP:0009660)	2.45384050
26	Microvesicular hepatic steatosis (HP:0001414)	2.42301452
27	True hermaphroditism (HP:0010459)	2.42026340
28	IgG deficiency (HP:0004315)	2.41431837
29	Methylmalonic acidemia (HP:0002912)	2.41397748
30	Mitochondrial inheritance (HP:0001427)	2.40477551
31	Chromsome breakage (HP:0040012)	2.37798526
32	Abnormality of the renal collecting system (HP:0004742)	2.36696646
33	Tubulointerstitial nephritis (HP:0001970)	2.29659999
34	Abnormality of the ileum (HP:0001549)	2.29450458
35	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.28171384
36	Short 1st metacarpal (HP:0010034)	2.28171384
37	Absent thumb (HP:0009777)	2.23524752
38	Hepatocellular necrosis (HP:0001404)	2.22978272
39	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.22527443
40	Meckel diverticulum (HP:0002245)	2.20338550
41	Abnormal mitochondria in muscle tissue (HP:0008316)	2.20167760
42	Methylmalonic aciduria (HP:0012120)	2.18926642
43	Clubbing of toes (HP:0100760)	2.17220277
44	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.16292083
45	Muscle fiber atrophy (HP:0100295)	2.14860456
46	Attenuation of retinal blood vessels (HP:0007843)	2.14303369
47	Aplasia/Hypoplasia of the macula (HP:0008059)	2.14194370
48	Abnormality of the renal cortex (HP:0011035)	2.12579927
49	Reticulocytopenia (HP:0001896)	2.12540392
50	Hepatic necrosis (HP:0002605)	2.09669414
51	Progressive inability to walk (HP:0002505)	2.09547051
52	Abnormality of T cell physiology (HP:0011840)	2.08933160
53	Long clavicles (HP:0000890)	2.08253641
54	Cerebral edema (HP:0002181)	2.06218299
55	Chronic hepatic failure (HP:0100626)	2.05273803
56	Pachygyria (HP:0001302)	2.04187911
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.03296317
58	Confusion (HP:0001289)	2.03106966
59	Gastrointestinal atresia (HP:0002589)	2.02106766
60	Optic disc pallor (HP:0000543)	2.01984579
61	Elevated erythrocyte sedimentation rate (HP:0003565)	2.01065531
62	Increased density of long bones (HP:0006392)	2.00564070
63	Aplasia/Hypoplasia affecting the retina (HP:0008061)	1.98791784
64	Abnormality of the 1st metacarpal (HP:0010009)	1.98123237
65	Pendular nystagmus (HP:0012043)	1.96997509
66	Dyschromatopsia (HP:0007641)	1.96535477
67	Type I transferrin isoform profile (HP:0003642)	1.93397469
68	Gastrointestinal infarctions (HP:0005244)	1.88916442
69	Abnormality of chromosome stability (HP:0003220)	1.87912069
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.86386434
71	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.86273374
72	Abnormality of DNA repair (HP:0003254)	1.85845223
73	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.85541652
74	Asplenia (HP:0001746)	1.85293717
75	Sloping forehead (HP:0000340)	1.85166041
76	Abnormality of the preputium (HP:0100587)	1.83719276
77	Tachypnea (HP:0002789)	1.83477641
78	Megalencephaly (HP:0001355)	1.83322052
79	Thyroiditis (HP:0100646)	1.82072566
80	Partial agenesis of the corpus callosum (HP:0001338)	1.78597746
81	Stomach cancer (HP:0012126)	1.78399897
82	Increased serum lactate (HP:0002151)	1.76995808
83	Abnormality of vitamin B metabolism (HP:0004340)	1.75575377
84	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.74790347
85	Lethargy (HP:0001254)	1.74686779
86	Optic neuritis (HP:0100653)	1.74637267
87	Retrobulbar optic neuritis (HP:0100654)	1.74637267
88	Hypoplasia of the pons (HP:0012110)	1.73465926
89	Short thumb (HP:0009778)	1.70699857
90	Abnormality of the pons (HP:0007361)	1.70336610
91	Meningioma (HP:0002858)	1.69165482
92	Hypoproteinemia (HP:0003075)	1.67284262
93	Keratoconjunctivitis (HP:0001096)	1.66908283
94	Macular degeneration (HP:0000608)	1.66875528
95	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.66706150
96	Ketoacidosis (HP:0001993)	1.66320833
97	Generalized hypopigmentation of hair (HP:0011358)	1.66301612
98	Hepatoblastoma (HP:0002884)	1.65010217
99	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.64836198
100	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.64720953

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.17899181
2	EIF2AK3	3.99863170
3	GRK1	3.51147964
4	ZAK	3.37871630
5	ADRBK2	3.07696522
6	FRK	2.75669932
7	PINK1	2.68263934
8	TLK1	2.27509797
9	CAMKK2	2.07775026
10	TRIM28	2.00619649
11	ACVR1B	1.89590124
12	TEC	1.86469158
13	TAOK3	1.84481966
14	BMPR1B	1.83206850
15	PDK2	1.80539636
16	BRSK2	1.72667439
17	NUAK1	1.72142460
18	INSRR	1.69973299
19	CLK1	1.68850130
20	MKNK2	1.43910398
21	TSSK6	1.39666001
22	WNK3	1.35777346
23	EIF2AK2	1.32758248
24	VRK1	1.28995527
25	DAPK2	1.28785673
26	MKNK1	1.25440709
27	STK16	1.24059496
28	TXK	1.19656693
29	SRPK1	1.18567909
30	MAPKAPK3	1.14595560
31	MARK1	1.13067967
32	MARK3	1.09155331
33	ITK	1.03608783
34	PLK3	1.03056602
35	OXSR1	1.01766744
36	PLK4	0.99941547
37	CDC7	0.95669390
38	MST4	0.95520965
39	PLK2	0.93889710
40	RPS6KA5	0.92253581
41	MAP3K4	0.90913758
42	DYRK2	0.90887987
43	TRPM7	0.90217300
44	AKT3	0.87756458
45	FGFR3	0.79926916
46	IKBKB	0.78972188
47	PRKCE	0.78626774
48	MAP2K6	0.76949311
49	CSNK1A1L	0.76573876
50	OBSCN	0.76296607
51	ADRBK1	0.75415658
52	TGFBR1	0.74855924
53	RPS6KB2	0.74613008
54	EIF2AK1	0.72842684
55	CSNK1G2	0.72340276
56	STK39	0.70311989
57	JAK3	0.68489496
58	PHKG1	0.67566529
59	PHKG2	0.67566529
60	CSNK1G3	0.67257452
61	BUB1	0.67193510
62	RPS6KA4	0.66996965
63	MAP3K14	0.66521688
64	DYRK1A	0.65508997
65	CSNK1D	0.64592156
66	PTK2B	0.64324027
67	CSNK1G1	0.63126360
68	PAK3	0.60833501
69	STK11	0.58722530
70	EPHA4	0.57182403
71	ILK	0.57061959
72	PASK	0.56363661
73	KIT	0.55961220
74	MAPKAPK5	0.54254473
75	NME1	0.53483375
76	TYRO3	0.53460987
77	PIK3CG	0.51972370
78	STK38L	0.51657948
79	MAPK13	0.50789552
80	BTK	0.49235455
81	IKBKE	0.48623386
82	ERBB3	0.45779168
83	NLK	0.43846720
84	IGF1R	0.41706430
85	DAPK1	0.41057018
86	CHUK	0.40271595
87	TNIK	0.39455174
88	VRK2	0.39432525
89	FES	0.38848218
90	FER	0.37548850
91	SYK	0.37048465
92	KSR1	0.36169892
93	LYN	0.35821507
94	ATM	0.35581449
95	PRKACA	0.34254116
96	EPHA3	0.34000882
97	PIM1	0.33556698
98	PRKCB	0.32657680
99	STK3	0.31480439
100	WNK1	0.31295506

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.19773316
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.00203220
3	Protein export_Homo sapiens_hsa03060	2.76334779
4	Basal transcription factors_Homo sapiens_hsa03022	2.71320484
5	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	2.68642188
6	Proteasome_Homo sapiens_hsa03050	2.65634100
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.40085544
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28554693
9	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.18316854
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.16315916
11	Allograft rejection_Homo sapiens_hsa05330	2.13499100
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.10988258
13	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.09965081
14	RNA polymerase_Homo sapiens_hsa03020	2.02048459
15	Propanoate metabolism_Homo sapiens_hsa00640	2.00793904
16	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.96850968
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.84896388
18	Phototransduction_Homo sapiens_hsa04744	1.83427094
19	RNA degradation_Homo sapiens_hsa03018	1.75943794
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.75854636
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.74391335
22	Ribosome_Homo sapiens_hsa03010	1.70730059
23	Homologous recombination_Homo sapiens_hsa03440	1.67204517
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.61057847
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.54511889
26	RNA transport_Homo sapiens_hsa03013	1.51933358
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.49327681
28	Type I diabetes mellitus_Homo sapiens_hsa04940	1.47180572
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.47086378
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.45519938
31	Butanoate metabolism_Homo sapiens_hsa00650	1.41065113
32	Parkinsons disease_Homo sapiens_hsa05012	1.40323652
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.37827661
34	Sulfur metabolism_Homo sapiens_hsa00920	1.34662213
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.31748077
36	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.24022899
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.22886613
38	Graft-versus-host disease_Homo sapiens_hsa05332	1.19635152
39	Caffeine metabolism_Homo sapiens_hsa00232	1.19026719
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17026991
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.15405420
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07426213
43	beta-Alanine metabolism_Homo sapiens_hsa00410	1.05905093
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04315848
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00035275
46	Selenocompound metabolism_Homo sapiens_hsa00450	0.99261039
47	Huntingtons disease_Homo sapiens_hsa05016	0.95366637
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.94998605
49	Retinol metabolism_Homo sapiens_hsa00830	0.92377687
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89794328
51	Serotonergic synapse_Homo sapiens_hsa04726	0.89338150
52	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83343678
53	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82376146
54	Alzheimers disease_Homo sapiens_hsa05010	0.81989480
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81899484
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81078041
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.80731325
58	Purine metabolism_Homo sapiens_hsa00230	0.77984254
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75638112
60	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.74639673
61	Taste transduction_Homo sapiens_hsa04742	0.74211618
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70926075
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69624360
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.68834194
65	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.68658439
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.66615394
67	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66210380
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66001348
69	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.64666647
70	Peroxisome_Homo sapiens_hsa04146	0.64664223
71	One carbon pool by folate_Homo sapiens_hsa00670	0.64620387
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62908884
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60263279
74	Metabolic pathways_Homo sapiens_hsa01100	0.55485423
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54695423
76	Circadian rhythm_Homo sapiens_hsa04710	0.54005228
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52509979
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.52218071
79	Regulation of autophagy_Homo sapiens_hsa04140	0.50399952
80	Nicotine addiction_Homo sapiens_hsa05033	0.47500673
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.44509128
82	Morphine addiction_Homo sapiens_hsa05032	0.44224519
83	Spliceosome_Homo sapiens_hsa03040	0.44184488
84	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.43494762
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.43374426
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.42712839
87	Olfactory transduction_Homo sapiens_hsa04740	0.39624112
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39263110
89	Salivary secretion_Homo sapiens_hsa04970	0.37801146
90	Measles_Homo sapiens_hsa05162	0.36086946
91	Pancreatic secretion_Homo sapiens_hsa04972	0.33514155
92	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.31641067
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.31308896
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29696347
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28352655
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.28225525
97	Cardiac muscle contraction_Homo sapiens_hsa04260	0.27582834
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.26908999
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25372012
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25317310

EEF1A1P32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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