ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	6.83553274
2	ribosomal small subunit biogenesis (GO:0042274)	5.49513665
3	ribosomal small subunit assembly (GO:0000028)	5.43827693
4	DNA deamination (GO:0045006)	5.38958219
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.28081698
6	viral transcription (GO:0019083)	5.09559539
7	translational termination (GO:0006415)	4.91043436
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.65493158
9	ATP synthesis coupled proton transport (GO:0015986)	4.65493158
10	ribosomal large subunit biogenesis (GO:0042273)	4.60359357
11	chaperone-mediated protein transport (GO:0072321)	4.58194106
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.42893306
13	pseudouridine synthesis (GO:0001522)	4.42123046
14	cotranslational protein targeting to membrane (GO:0006613)	4.34090631
15	translational elongation (GO:0006414)	4.33925447
16	protein targeting to ER (GO:0045047)	4.30341657
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.30199333
18	rRNA modification (GO:0000154)	4.28018538
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.22848256
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.20056486
21	NADH dehydrogenase complex assembly (GO:0010257)	4.20056486
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.20056486
23	ribonucleoprotein complex biogenesis (GO:0022613)	4.20031468
24	behavioral response to nicotine (GO:0035095)	4.14229709
25	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.11876100
26	protein localization to endoplasmic reticulum (GO:0070972)	4.01164894
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.95006119
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.90274083
29	termination of RNA polymerase III transcription (GO:0006386)	3.90274083
30	rRNA processing (GO:0006364)	3.89119370
31	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.86403541
32	positive regulation of prostaglandin secretion (GO:0032308)	3.84852817
33	cellular component biogenesis (GO:0044085)	3.84494775
34	protein complex biogenesis (GO:0070271)	3.83678862
35	rRNA metabolic process (GO:0016072)	3.83086962
36	translation (GO:0006412)	3.81581811
37	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.80813664
38	GTP biosynthetic process (GO:0006183)	3.80510577
39	rRNA methylation (GO:0031167)	3.78447979
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.72773033
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.72773033
42	translational initiation (GO:0006413)	3.71880187
43	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.71586015
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.70951260
45	protein neddylation (GO:0045116)	3.68972923
46	ribosome biogenesis (GO:0042254)	3.67713922
47	proteasome assembly (GO:0043248)	3.64503087
48	cellular protein complex disassembly (GO:0043624)	3.64206564
49	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.61189756
50	viral life cycle (GO:0019058)	3.59433965
51	electron transport chain (GO:0022900)	3.49605271
52	respiratory electron transport chain (GO:0022904)	3.48266893
53	peptidyl-histidine modification (GO:0018202)	3.46160200
54	UTP biosynthetic process (GO:0006228)	3.43641526
55	cullin deneddylation (GO:0010388)	3.42640700
56	positive regulation of defense response to virus by host (GO:0002230)	3.38350109
57	UTP metabolic process (GO:0046051)	3.30550784
58	protein deneddylation (GO:0000338)	3.27602192
59	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.17598772
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.15873144
61	tRNA processing (GO:0008033)	3.11147987
62	protein targeting to mitochondrion (GO:0006626)	3.04236107
63	guanosine-containing compound biosynthetic process (GO:1901070)	3.03066804
64	fucose catabolic process (GO:0019317)	2.99205152
65	L-fucose metabolic process (GO:0042354)	2.99205152
66	L-fucose catabolic process (GO:0042355)	2.99205152
67	ncRNA processing (GO:0034470)	2.97766407
68	protein complex disassembly (GO:0043241)	2.97074163
69	regulation of prostaglandin secretion (GO:0032306)	2.96219392
70	ubiquinone biosynthetic process (GO:0006744)	2.95664629
71	ATP biosynthetic process (GO:0006754)	2.95461323
72	establishment of protein localization to mitochondrion (GO:0072655)	2.95229159
73	protein localization to mitochondrion (GO:0070585)	2.92792077
74	ncRNA metabolic process (GO:0034660)	2.91974922
75	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.89117723
76	positive regulation of fatty acid transport (GO:2000193)	2.89061303
77	nucleoside diphosphate phosphorylation (GO:0006165)	2.88765455
78	regulation of mitochondrial translation (GO:0070129)	2.87641377
79	DNA damage response, detection of DNA damage (GO:0042769)	2.86733589
80	GMP metabolic process (GO:0046037)	2.85880959
81	macromolecular complex disassembly (GO:0032984)	2.85153250
82	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.84084826
83	respiratory chain complex IV assembly (GO:0008535)	2.83840951
84	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.80704306
85	intracellular protein transmembrane import (GO:0044743)	2.79814410
86	spliceosomal snRNP assembly (GO:0000387)	2.78672148
87	tRNA metabolic process (GO:0006399)	2.78544865
88	hydrogen ion transmembrane transport (GO:1902600)	2.76605361
89	maturation of 5.8S rRNA (GO:0000460)	2.74876868
90	mRNA catabolic process (GO:0006402)	2.72525515
91	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.71064202
92	CTP metabolic process (GO:0046036)	2.70041057
93	CTP biosynthetic process (GO:0006241)	2.70041057
94	chromatin remodeling at centromere (GO:0031055)	2.67084343
95	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.66566358
96	proton transport (GO:0015992)	2.63808113
97	spliceosomal complex assembly (GO:0000245)	2.63639824
98	positive regulation of icosanoid secretion (GO:0032305)	2.62646452
99	protein targeting to membrane (GO:0006612)	2.62392921
100	regulation of cellular amino acid metabolic process (GO:0006521)	2.62240473

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.78209586
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.56107258
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.28808722
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.08035215
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.78462498
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.44943417
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.35975242
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.13299086
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.86090988
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.77991358
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62297157
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.61347839
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.48009292
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.28669611
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.20905306
16	VDR_22108803_ChIP-Seq_LS180_Human	2.18425142
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.09060629
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00909348
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.96352816
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.93461361
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.91749607
22	TTF2_22483619_ChIP-Seq_HELA_Human	1.89563140
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86175690
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84990601
25	EWS_26573619_Chip-Seq_HEK293_Human	1.84721660
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.79146555
27	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73221888
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.72520665
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.65893056
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.59311671
31	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.58603304
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.58412841
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.57628605
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.57367685
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.56955244
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53786298
37	EZH2_22144423_ChIP-Seq_EOC_Human	1.52515434
38	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.52192191
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.51014765
40	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49655434
41	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.49201512
42	FUS_26573619_Chip-Seq_HEK293_Human	1.48976084
43	XRN2_22483619_ChIP-Seq_HELA_Human	1.47400960
44	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46646363
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46455193
46	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.44180079
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.36219053
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33495559
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32796264
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.27699029
51	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26991401
52	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25046527
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.20668867
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.19677218
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.16647396
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.16647396
57	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.16134375
58	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.15453527
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14756306
60	NCOR_22424771_ChIP-Seq_293T_Human	1.11737335
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11108628
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10032664
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10032664
64	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09823899
65	AR_20517297_ChIP-Seq_VCAP_Human	1.07512128
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06850950
67	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06594108
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04902356
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04008447
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02446590
71	MYC_19829295_ChIP-Seq_ESCs_Human	1.00835299
72	KDM5A_27292631_Chip-Seq_BREAST_Human	1.00605698
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00253430
74	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.99524964
75	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.99089557
76	P300_19829295_ChIP-Seq_ESCs_Human	0.98845528
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.98717529
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98512487
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97771078
80	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.96933496
81	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.96856371
82	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96392742
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.95552475
84	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.92312421
85	IGF1R_20145208_ChIP-Seq_DFB_Human	0.90769339
86	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.90461576
87	ERA_21632823_ChIP-Seq_H3396_Human	0.90057915
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.89661884
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.89364288
90	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89205519
91	ER_23166858_ChIP-Seq_MCF-7_Human	0.88904519
92	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.87717671
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.87301579
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.86218744
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.85717846
96	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.85402846
97	NANOG_20526341_ChIP-Seq_ESCs_Human	0.85250185
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.83774057
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.82410257
100	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.82273879

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.72297134
2	MP0002163_abnormal_gland_morphology	3.29286878
3	MP0002102_abnormal_ear_morphology	2.96071187
4	MP0009379_abnormal_foot_pigmentation	2.85239803
5	MP0003283_abnormal_digestive_organ	2.63985198
6	MP0006292_abnormal_olfactory_placode	2.51917809
7	MP0008872_abnormal_physiological_respon	2.32889991
8	MP0008877_abnormal_DNA_methylation	2.29449902
9	MP0005646_abnormal_pituitary_gland	2.28487820
10	MP0006072_abnormal_retinal_apoptosis	2.18616179
11	MP0002876_abnormal_thyroid_physiology	2.16268824
12	MP0004142_abnormal_muscle_tone	2.08832917
13	MP0002234_abnormal_pharynx_morphology	2.03643588
14	MP0008875_abnormal_xenobiotic_pharmacok	1.96018667
15	MP0004145_abnormal_muscle_electrophysio	1.89397794
16	MP0005379_endocrine/exocrine_gland_phen	1.86771924
17	MP0003806_abnormal_nucleotide_metabolis	1.83802159
18	MP0000685_abnormal_immune_system	1.82554773
19	MP0004885_abnormal_endolymph	1.76184743
20	MP0005084_abnormal_gallbladder_morpholo	1.74138893
21	MP0004742_abnormal_vestibular_system	1.73970501
22	MP0005551_abnormal_eye_electrophysiolog	1.73294847
23	MP0005671_abnormal_response_to	1.72064111
24	MP0002160_abnormal_reproductive_system	1.70620179
25	MP0001968_abnormal_touch/_nociception	1.68783552
26	MP0001485_abnormal_pinna_reflex	1.62742480
27	MP0002277_abnormal_respiratory_mucosa	1.60615182
28	MP0002736_abnormal_nociception_after	1.59340686
29	MP0005389_reproductive_system_phenotype	1.58827140
30	MP0004147_increased_porphyrin_level	1.55747412
31	MP0003787_abnormal_imprinting	1.55643872
32	MP0001986_abnormal_taste_sensitivity	1.54279248
33	MP0001293_anophthalmia	1.54031128
34	MP0008058_abnormal_DNA_repair	1.50242975
35	MP0003567_abnormal_fetal_cardiomyocyte	1.46465303
36	MP0009764_decreased_sensitivity_to	1.37940254
37	MP0003786_premature_aging	1.36317259
38	MP0002938_white_spotting	1.35441319
39	MP0002272_abnormal_nervous_system	1.34227382
40	MP0006276_abnormal_autonomic_nervous	1.32098083
41	MP0003186_abnormal_redox_activity	1.30283886
42	MP0003646_muscle_fatigue	1.28870001
43	MP0003693_abnormal_embryo_hatching	1.28052616
44	MP0009053_abnormal_anal_canal	1.26796805
45	MP0008775_abnormal_heart_ventricle	1.26791605
46	MP0002148_abnormal_hypersensitivity_rea	1.26677823
47	MP0000372_irregular_coat_pigmentation	1.22784336
48	MP0000631_abnormal_neuroendocrine_gland	1.21735927
49	MP0002837_dystrophic_cardiac_calcinosis	1.20412761
50	MP0001919_abnormal_reproductive_system	1.19935737
51	MP0006036_abnormal_mitochondrial_physio	1.19720717
52	MP0006035_abnormal_mitochondrial_morpho	1.17756247
53	MP0001440_abnormal_grooming_behavior	1.15765813
54	MP0009046_muscle_twitch	1.15649498
55	MP0001529_abnormal_vocalization	1.13621322
56	MP0002138_abnormal_hepatobiliary_system	1.10425219
57	MP0004133_heterotaxia	1.07839565
58	MP0009745_abnormal_behavioral_response	1.07378495
59	MP0001905_abnormal_dopamine_level	1.06745525
60	MP0009333_abnormal_splenocyte_physiolog	1.06530499
61	MP0003718_maternal_effect	1.03085222
62	MP0003866_abnormal_defecation	1.02342367
63	MP0001501_abnormal_sleep_pattern	1.02002170
64	MP0003937_abnormal_limbs/digits/tail_de	0.97085864
65	MP0009250_abnormal_appendicular_skeleto	0.96707624
66	MP0000613_abnormal_salivary_gland	0.93639847
67	MP0000049_abnormal_middle_ear	0.93268406
68	MP0003880_abnormal_central_pattern	0.91125976
69	MP0008995_early_reproductive_senescence	0.89669425
70	MP0003123_paternal_imprinting	0.88513546
71	MP0003121_genomic_imprinting	0.87941689
72	MP0005253_abnormal_eye_physiology	0.87428964
73	MP0005636_abnormal_mineral_homeostasis	0.86869631
74	MP0001790_abnormal_immune_system	0.84700664
75	MP0005387_immune_system_phenotype	0.84700664
76	MP0005075_abnormal_melanosome_morpholog	0.84520932
77	MP0001764_abnormal_homeostasis	0.84515239
78	MP0005645_abnormal_hypothalamus_physiol	0.84448781
79	MP0001835_abnormal_antigen_presentation	0.83323663
80	MP0002210_abnormal_sex_determination	0.82988080
81	MP0003119_abnormal_digestive_system	0.81495795
82	MP0005377_hearing/vestibular/ear_phenot	0.80866502
83	MP0003878_abnormal_ear_physiology	0.80866502
84	MP0005410_abnormal_fertilization	0.80848923
85	MP0001963_abnormal_hearing_physiology	0.76341128
86	MP0005332_abnormal_amino_acid	0.76055074
87	MP0003936_abnormal_reproductive_system	0.75261623
88	MP0001145_abnormal_male_reproductive	0.74003306
89	MP0000026_abnormal_inner_ear	0.73642221
90	MP0001873_stomach_inflammation	0.73090466
91	MP0000566_synostosis	0.73062467
92	MP0005195_abnormal_posterior_eye	0.73036217
93	MP0001800_abnormal_humoral_immune	0.71784072
94	MP0001188_hyperpigmentation	0.71138497
95	MP0002928_abnormal_bile_duct	0.69701509
96	MP0001663_abnormal_digestive_system	0.68155333
97	MP0000653_abnormal_sex_gland	0.67849249
98	MP0001929_abnormal_gametogenesis	0.66906558
99	MP0004215_abnormal_myocardial_fiber	0.66295136
100	MP0003938_abnormal_ear_development	0.65751478

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.26306085
2	Acute encephalopathy (HP:0006846)	3.82830383
3	Mitochondrial inheritance (HP:0001427)	3.76377354
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.73417492
5	3-Methylglutaconic aciduria (HP:0003535)	3.67424126
6	Hepatocellular necrosis (HP:0001404)	3.61738418
7	Increased CSF lactate (HP:0002490)	3.54832474
8	Progressive macrocephaly (HP:0004481)	3.51527757
9	Reticulocytopenia (HP:0001896)	3.39711205
10	Hepatic necrosis (HP:0002605)	3.28769089
11	Pancreatic cysts (HP:0001737)	3.27883545
12	Abnormality of midbrain morphology (HP:0002418)	3.13533974
13	Molar tooth sign on MRI (HP:0002419)	3.13533974
14	Abnormality of alanine metabolism (HP:0010916)	3.02749716
15	Hyperalaninemia (HP:0003348)	3.02749716
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.02749716
17	Abnormality of cells of the erythroid lineage (HP:0012130)	3.01080401
18	Pancreatic fibrosis (HP:0100732)	2.97743974
19	True hermaphroditism (HP:0010459)	2.97679151
20	Congenital stationary night blindness (HP:0007642)	2.95314526
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.94533426
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.94533426
23	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.93235269
24	Macrocytic anemia (HP:0001972)	2.89653579
25	Nephronophthisis (HP:0000090)	2.78147032
26	Abnormality of the labia minora (HP:0012880)	2.77419084
27	Increased serum lactate (HP:0002151)	2.74405992
28	Cerebral edema (HP:0002181)	2.66775816
29	Abnormal number of erythroid precursors (HP:0012131)	2.62581066
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.59831675
31	Hyperglycinemia (HP:0002154)	2.58913245
32	IgG deficiency (HP:0004315)	2.58886771
33	Abnormality of the pons (HP:0007361)	2.57304533
34	Optic disc pallor (HP:0000543)	2.52770854
35	Pendular nystagmus (HP:0012043)	2.50702724
36	Colon cancer (HP:0003003)	2.47079891
37	Aplasia/hypoplasia of the uterus (HP:0008684)	2.46968073
38	Abnormality of the middle phalanges of the toes (HP:0010183)	2.43267748
39	Stomatitis (HP:0010280)	2.41956911
40	Abolished electroretinogram (ERG) (HP:0000550)	2.37279431
41	Hypoplasia of the pons (HP:0012110)	2.36134356
42	Type II lissencephaly (HP:0007260)	2.34119139
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29098901
44	Respiratory failure (HP:0002878)	2.28952986
45	Lactic acidosis (HP:0003128)	2.28919965
46	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.28573238
47	Abnormality of the renal medulla (HP:0100957)	2.25620295
48	Leukodystrophy (HP:0002415)	2.24178810
49	Hyperglycinuria (HP:0003108)	2.23416181
50	Cerebral hypomyelination (HP:0006808)	2.22719766
51	Abnormality of the renal cortex (HP:0011035)	2.21535926
52	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.19036066
53	Congenital, generalized hypertrichosis (HP:0004540)	2.18251070
54	Hypoplasia of the radius (HP:0002984)	2.17460594
55	Stenosis of the external auditory canal (HP:0000402)	2.16113894
56	Increased hepatocellular lipid droplets (HP:0006565)	2.10782982
57	Lethargy (HP:0001254)	2.09571100
58	Degeneration of anterior horn cells (HP:0002398)	2.07058926
59	Abnormality of the anterior horn cell (HP:0006802)	2.07058926
60	Hypoplasia of the uterus (HP:0000013)	2.03133445
61	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.02908841
62	Occipital encephalocele (HP:0002085)	2.01057130
63	Pallor (HP:0000980)	1.99125744
64	Keratoconus (HP:0000563)	1.98147321
65	Increased corneal curvature (HP:0100692)	1.98147321
66	Increased serum pyruvate (HP:0003542)	1.96152642
67	Oral leukoplakia (HP:0002745)	1.95730706
68	Absent thumb (HP:0009777)	1.95107416
69	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.94643510
70	Anencephaly (HP:0002323)	1.93183370
71	Methylmalonic aciduria (HP:0012120)	1.93162941
72	Lipid accumulation in hepatocytes (HP:0006561)	1.92484381
73	CNS demyelination (HP:0007305)	1.92362604
74	Abnormal drinking behavior (HP:0030082)	1.89880266
75	Polydipsia (HP:0001959)	1.89880266
76	Bilateral microphthalmos (HP:0007633)	1.88461592
77	Medial flaring of the eyebrow (HP:0010747)	1.87665701
78	Sclerocornea (HP:0000647)	1.85583992
79	Blindness (HP:0000618)	1.84857836
80	Abnormality of serum amino acid levels (HP:0003112)	1.82825770
81	Testicular atrophy (HP:0000029)	1.82289285
82	Tubular atrophy (HP:0000092)	1.81542001
83	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.80014614
84	Microretrognathia (HP:0000308)	1.79504364
85	Large for gestational age (HP:0001520)	1.78988192
86	Horseshoe kidney (HP:0000085)	1.78854501
87	Pancytopenia (HP:0001876)	1.78492806
88	Male pseudohermaphroditism (HP:0000037)	1.76405620
89	Triphalangeal thumb (HP:0001199)	1.75141450
90	Cleft eyelid (HP:0000625)	1.73243439
91	Abnormality of glycine metabolism (HP:0010895)	1.71515466
92	Abnormality of serine family amino acid metabolism (HP:0010894)	1.71515466
93	Cystic liver disease (HP:0006706)	1.71452970
94	Radial bowing (HP:0002986)	1.70738537
95	Asplenia (HP:0001746)	1.70297244
96	Adrenal hypoplasia (HP:0000835)	1.68987353
97	Constricted visual fields (HP:0001133)	1.68985419
98	Decreased central vision (HP:0007663)	1.68829988
99	Progressive microcephaly (HP:0000253)	1.67997638
100	Abnormality of the renal collecting system (HP:0004742)	1.67542980

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.77042713
2	NUAK1	3.12129761
3	ZAK	3.02754356
4	TAOK3	2.94242737
5	BUB1	2.75220042
6	VRK2	2.64078696
7	TXK	2.58997525
8	TSSK6	2.47785947
9	NME2	2.35283205
10	TIE1	2.34018955
11	WNK3	2.27961897
12	GRK1	2.20950001
13	ADRBK2	2.09782086
14	MAP4K2	2.09414334
15	WNK4	2.07528777
16	STK16	2.07328030
17	EIF2AK1	1.83937951
18	FRK	1.81908494
19	TAF1	1.75911929
20	DYRK2	1.72764731
21	VRK1	1.64643852
22	STK39	1.58035393
23	SIK2	1.56079485
24	EIF2AK3	1.53774806
25	PASK	1.52155667
26	NEK1	1.50438812
27	SRPK1	1.43226479
28	MST4	1.41035612
29	PDK2	1.37061889
30	MUSK	1.36461167
31	TEC	1.26431665
32	IKBKB	1.15677265
33	INSRR	1.15582842
34	PINK1	1.14522577
35	BCKDK	1.13242940
36	PLK3	1.12967112
37	CSNK1G1	1.12306491
38	CSNK1G3	1.11270799
39	CSNK1G2	1.08361807
40	OXSR1	1.07785725
41	MAP3K4	1.00738109
42	MAP3K12	0.98690188
43	CSNK1A1L	0.96838328
44	ALK	0.93544566
45	NLK	0.87408839
46	PLK4	0.84229966
47	TRIM28	0.81545527
48	MAP2K7	0.81189219
49	CDK19	0.80000255
50	RPS6KA5	0.79782287
51	MAPKAPK3	0.78705660
52	CDC7	0.76548806
53	TGFBR1	0.69955965
54	PHKG2	0.68598436
55	PHKG1	0.68598436
56	WNK1	0.68569031
57	PRKCQ	0.68123255
58	MAPKAPK5	0.67788118
59	BMPR1B	0.66730129
60	IRAK1	0.66107990
61	MKNK1	0.65749075
62	EIF2AK2	0.62637621
63	PLK2	0.62413899
64	MKNK2	0.61000105
65	PLK1	0.60726029
66	PRKCG	0.59182322
67	NEK2	0.52828144
68	CSNK2A2	0.52684547
69	CSNK1E	0.49926705
70	PIK3CA	0.46896579
71	CAMKK2	0.46802231
72	ADRBK1	0.44865694
73	CSNK2A1	0.44647719
74	ATR	0.44060656
75	MAPK13	0.43021261
76	DAPK3	0.41765405
77	EPHA3	0.40341015
78	GRK5	0.40271129
79	AURKB	0.39022139
80	LRRK2	0.38097969
81	BMPR2	0.37288603
82	CSNK1A1	0.37206685
83	KIT	0.36124570
84	ITK	0.35566799
85	MAP3K11	0.34682282
86	TTK	0.34251132
87	IKBKE	0.34213224
88	PNCK	0.33661809
89	PRKCI	0.33308609
90	PRKACA	0.33026941
91	AURKA	0.32271774
92	MARK3	0.32056370
93	TNIK	0.31258439
94	FES	0.30902611
95	BCR	0.30417435
96	SIK3	0.30351252
97	CHUK	0.29458671
98	PRKCE	0.29147016
99	CAMK2A	0.28923112
100	RPS6KB2	0.27218988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.88211015
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.62920233
3	Proteasome_Homo sapiens_hsa03050	3.33164694
4	RNA polymerase_Homo sapiens_hsa03020	2.94394193
5	Parkinsons disease_Homo sapiens_hsa05012	2.91727612
6	One carbon pool by folate_Homo sapiens_hsa00670	2.70723512
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.49931155
8	Protein export_Homo sapiens_hsa03060	2.34020562
9	Huntingtons disease_Homo sapiens_hsa05016	2.04034476
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03984625
11	Alzheimers disease_Homo sapiens_hsa05010	1.93600579
12	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.88504103
13	RNA degradation_Homo sapiens_hsa03018	1.85950949
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85655142
15	Asthma_Homo sapiens_hsa05310	1.73805150
16	Homologous recombination_Homo sapiens_hsa03440	1.69142970
17	Basal transcription factors_Homo sapiens_hsa03022	1.66393737
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62393178
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55539184
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52688087
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.50020980
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.49813201
23	Phototransduction_Homo sapiens_hsa04744	1.48937993
24	Propanoate metabolism_Homo sapiens_hsa00640	1.45350729
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44743077
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.40894951
27	Spliceosome_Homo sapiens_hsa03040	1.39933911
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.37138058
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.33486780
30	RNA transport_Homo sapiens_hsa03013	1.28233689
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.26937631
32	Selenocompound metabolism_Homo sapiens_hsa00450	1.26077050
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26068614
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.25230942
35	Allograft rejection_Homo sapiens_hsa05330	1.19250763
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.19220589
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.17983831
38	Primary immunodeficiency_Homo sapiens_hsa05340	1.15311525
39	Purine metabolism_Homo sapiens_hsa00230	1.13119057
40	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.09298663
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.09024379
42	Fanconi anemia pathway_Homo sapiens_hsa03460	1.08764614
43	Sulfur relay system_Homo sapiens_hsa04122	1.08733749
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05097598
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.05094684
46	Caffeine metabolism_Homo sapiens_hsa00232	1.03231089
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.96625343
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95993785
49	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.92958631
50	Sulfur metabolism_Homo sapiens_hsa00920	0.92509131
51	Mismatch repair_Homo sapiens_hsa03430	0.91343002
52	Nicotine addiction_Homo sapiens_hsa05033	0.90067861
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.89996604
54	DNA replication_Homo sapiens_hsa03030	0.87843309
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86544566
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.86143942
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84146330
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.83686785
59	Peroxisome_Homo sapiens_hsa04146	0.82597157
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.82285637
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82205791
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.81771431
63	Antigen processing and presentation_Homo sapiens_hsa04612	0.75648128
64	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74111153
65	Metabolic pathways_Homo sapiens_hsa01100	0.72699066
66	Base excision repair_Homo sapiens_hsa03410	0.71971111
67	Butanoate metabolism_Homo sapiens_hsa00650	0.70901747
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.67604706
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.67205746
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.67019468
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65403662
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.64790186
73	Folate biosynthesis_Homo sapiens_hsa00790	0.61127866
74	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60882916
75	Retinol metabolism_Homo sapiens_hsa00830	0.59512251
76	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57991867
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.56532243
78	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.54390855
79	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54038413
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52446515
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50591051
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46641791
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46499343
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46157467
85	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43750607
86	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43455323
87	Fatty acid degradation_Homo sapiens_hsa00071	0.43413177
88	Glutathione metabolism_Homo sapiens_hsa00480	0.42083358
89	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39566366
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37066512
91	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37054522
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31833225
93	Olfactory transduction_Homo sapiens_hsa04740	0.31276546
94	Regulation of autophagy_Homo sapiens_hsa04140	0.30412578
95	Taste transduction_Homo sapiens_hsa04742	0.30241423
96	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28228711
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.26055006
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.25736007
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.24393828
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20351037

EEF1A1P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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