ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.74967180
2	viral transcription (GO:0019083)	5.38483428
3	translational termination (GO:0006415)	5.14098331
4	DNA deamination (GO:0045006)	5.12638438
5	maturation of SSU-rRNA (GO:0030490)	5.10608161
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.75418963
7	ATP synthesis coupled proton transport (GO:0015986)	4.75418963
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.70476801
9	behavioral response to nicotine (GO:0035095)	4.69694550
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.66145339
11	translational elongation (GO:0006414)	4.63964901
12	cotranslational protein targeting to membrane (GO:0006613)	4.60271061
13	protein targeting to ER (GO:0045047)	4.57374549
14	water-soluble vitamin biosynthetic process (GO:0042364)	4.41449888
15	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.36262447
16	protein localization to endoplasmic reticulum (GO:0070972)	4.31515835
17	chaperone-mediated protein transport (GO:0072321)	4.21836552
18	viral life cycle (GO:0019058)	4.08455489
19	regulation of isotype switching to IgG isotypes (GO:0048302)	3.96150375
20	ribosomal small subunit biogenesis (GO:0042274)	3.92229226
21	GTP biosynthetic process (GO:0006183)	3.87900888
22	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.87167401
23	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.86860341
24	cellular protein complex disassembly (GO:0043624)	3.86518580
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.85472603
26	translational initiation (GO:0006413)	3.81405967
27	ribosomal large subunit biogenesis (GO:0042273)	3.80294947
28	fucose catabolic process (GO:0019317)	3.73321647
29	L-fucose metabolic process (GO:0042354)	3.73321647
30	L-fucose catabolic process (GO:0042355)	3.73321647
31	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.65911302
32	peptidyl-histidine modification (GO:0018202)	3.65008519
33	protein complex biogenesis (GO:0070271)	3.52763853
34	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.52358056
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47489513
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47489513
37	translation (GO:0006412)	3.43411159
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.42880921
39	regulation of immunoglobulin secretion (GO:0051023)	3.40633461
40	UTP biosynthetic process (GO:0006228)	3.35783192
41	head development (GO:0060322)	3.28666208
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25589661
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25589661
44	NADH dehydrogenase complex assembly (GO:0010257)	3.25589661
45	mitochondrial respiratory chain complex assembly (GO:0033108)	3.22943155
46	rRNA modification (GO:0000154)	3.22050443
47	protein complex disassembly (GO:0043241)	3.21534085
48	UTP metabolic process (GO:0046051)	3.17869302
49	macromolecular complex disassembly (GO:0032984)	3.13701812
50	protein neddylation (GO:0045116)	3.12317756
51	ribonucleoprotein complex biogenesis (GO:0022613)	3.11524197
52	ubiquinone biosynthetic process (GO:0006744)	3.10753951
53	cellular component biogenesis (GO:0044085)	3.08036869
54	negative regulation of telomere maintenance (GO:0032205)	3.03830878
55	regulation of chronic inflammatory response (GO:0002676)	3.01004801
56	protein deneddylation (GO:0000338)	3.00766288
57	protein targeting to membrane (GO:0006612)	2.98610663
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.96960060
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.96858339
60	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.96164430
61	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.95488032
62	rRNA processing (GO:0006364)	2.94119849
63	somite development (GO:0061053)	2.92549413
64	positive regulation of prostaglandin secretion (GO:0032308)	2.92017520
65	rRNA metabolic process (GO:0016072)	2.91309388
66	ubiquinone metabolic process (GO:0006743)	2.91077708
67	base-excision repair, AP site formation (GO:0006285)	2.86701848
68	protein-cofactor linkage (GO:0018065)	2.86483688
69	regulation of regulatory T cell differentiation (GO:0045589)	2.85380896
70	spinal cord association neuron differentiation (GO:0021527)	2.85287857
71	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.85076816
72	termination of RNA polymerase III transcription (GO:0006386)	2.85076816
73	intracellular protein transmembrane import (GO:0044743)	2.82237552
74	mRNA catabolic process (GO:0006402)	2.80234475
75	endoderm formation (GO:0001706)	2.78895900
76	CTP biosynthetic process (GO:0006241)	2.74514135
77	CTP metabolic process (GO:0046036)	2.74514135
78	tRNA processing (GO:0008033)	2.73736383
79	positive regulation of fatty acid transport (GO:2000193)	2.73491866
80	positive regulation of protein homooligomerization (GO:0032464)	2.73236645
81	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.71938988
82	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.71361633
83	electron transport chain (GO:0022900)	2.69394514
84	ATP biosynthetic process (GO:0006754)	2.68108061
85	respiratory electron transport chain (GO:0022904)	2.67432494
86	rRNA methylation (GO:0031167)	2.66873485
87	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.64952056
88	cullin deneddylation (GO:0010388)	2.63700230
89	ribosome biogenesis (GO:0042254)	2.61984436
90	pseudouridine synthesis (GO:0001522)	2.61632478
91	hydrogen ion transmembrane transport (GO:1902600)	2.61016979
92	respiratory chain complex IV assembly (GO:0008535)	2.60528408
93	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.60093168
94	quinone biosynthetic process (GO:1901663)	2.59714854
95	aldehyde catabolic process (GO:0046185)	2.59686658
96	cellular response to interferon-beta (GO:0035458)	2.57995436
97	proteasome assembly (GO:0043248)	2.56416360
98	proton transport (GO:0015992)	2.55754050
99	tRNA metabolic process (GO:0006399)	2.55349702
100	negative regulation of B cell apoptotic process (GO:0002903)	2.53419396

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.16331527
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.67100754
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.12136522
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.67422226
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.43603364
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.13360886
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12525164
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.90308270
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.86440122
10	VDR_22108803_ChIP-Seq_LS180_Human	2.47969343
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.38785147
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.35001952
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.14767951
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.11684356
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.09554131
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05645227
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.94305961
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91705977
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.90614676
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.87089698
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82147670
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78387305
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.78120195
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69651854
25	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.68691898
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68148661
27	ELK1_19687146_ChIP-ChIP_HELA_Human	1.67073345
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.63351693
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62359028
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61643568
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.61001097
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60552174
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.58931417
34	EWS_26573619_Chip-Seq_HEK293_Human	1.58331489
35	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.52707856
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.48565468
37	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42070555
38	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.40936966
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40351761
40	IGF1R_20145208_ChIP-Seq_DFB_Human	1.38153373
41	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.34417395
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.33892822
43	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33101811
44	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31002046
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.30530991
46	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.26903160
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22966738
48	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.22489990
49	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21462284
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18685253
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18685253
52	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18252096
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15806997
54	ERA_21632823_ChIP-Seq_H3396_Human	1.14583020
55	P300_19829295_ChIP-Seq_ESCs_Human	1.13037574
56	NCOR_22424771_ChIP-Seq_293T_Human	1.12756658
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11817518
58	FUS_26573619_Chip-Seq_HEK293_Human	1.11593975
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.09751917
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09744291
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09744291
62	MYC_19829295_ChIP-Seq_ESCs_Human	1.07185463
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06667822
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.06510867
65	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06142891
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05921299
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05009316
68	XRN2_22483619_ChIP-Seq_HELA_Human	1.04804176
69	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02335508
70	AR_20517297_ChIP-Seq_VCAP_Human	1.01646879
71	GBX2_23144817_ChIP-Seq_PC3_Human	1.01273705
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01206840
73	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.99509353
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98531707
75	CBP_20019798_ChIP-Seq_JUKART_Human	0.98341407
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.98341407
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97278608
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96946193
79	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.96928260
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.96263994
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.95859174
82	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.95470739
83	DCP1A_22483619_ChIP-Seq_HELA_Human	0.94565947
84	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.94270712
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.93756824
86	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93510157
87	ER_23166858_ChIP-Seq_MCF-7_Human	0.91508147
88	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.90887761
89	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90578000
90	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.89460499
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.88679333
92	RNF2_27304074_Chip-Seq_NSC_Mouse	0.88603804
93	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.88376278
94	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87347404
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86745545
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.85465031
97	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.82569851
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.82126476
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.81994537
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.80958647

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.16419644
2	MP0006292_abnormal_olfactory_placode	3.95787470
3	MP0001986_abnormal_taste_sensitivity	3.14419773
4	MP0008877_abnormal_DNA_methylation	2.85651130
5	MP0004147_increased_porphyrin_level	2.85444961
6	MP0003122_maternal_imprinting	2.48176620
7	MP0002102_abnormal_ear_morphology	2.36213749
8	MP0002653_abnormal_ependyma_morphology	2.35310655
9	MP0002138_abnormal_hepatobiliary_system	2.25543411
10	MP0008875_abnormal_xenobiotic_pharmacok	2.25048269
11	MP0008872_abnormal_physiological_respon	2.24577671
12	MP0003646_muscle_fatigue	2.16979848
13	MP0005645_abnormal_hypothalamus_physiol	2.06396774
14	MP0003011_delayed_dark_adaptation	2.02883715
15	MP0003878_abnormal_ear_physiology	2.00673436
16	MP0005377_hearing/vestibular/ear_phenot	2.00673436
17	MP0001968_abnormal_touch/_nociception	1.95354889
18	MP0004142_abnormal_muscle_tone	1.92924995
19	MP0003787_abnormal_imprinting	1.88411885
20	MP0004885_abnormal_endolymph	1.85941168
21	MP0005646_abnormal_pituitary_gland	1.84736561
22	MP0001873_stomach_inflammation	1.77429313
23	MP0000372_irregular_coat_pigmentation	1.71851526
24	MP0005084_abnormal_gallbladder_morpholo	1.70424786
25	MP0002736_abnormal_nociception_after	1.68582961
26	MP0006072_abnormal_retinal_apoptosis	1.67794704
27	MP0002277_abnormal_respiratory_mucosa	1.67738450
28	MP0002938_white_spotting	1.65200269
29	MP0002163_abnormal_gland_morphology	1.64917298
30	MP0002837_dystrophic_cardiac_calcinosis	1.62541313
31	MP0001293_anophthalmia	1.57253101
32	MP0002272_abnormal_nervous_system	1.51074532
33	MP0004742_abnormal_vestibular_system	1.50577983
34	MP0003136_yellow_coat_color	1.50152933
35	MP0003121_genomic_imprinting	1.49837890
36	MP0005551_abnormal_eye_electrophysiolog	1.47159602
37	MP0001835_abnormal_antigen_presentation	1.42134815
38	MP0003718_maternal_effect	1.40639123
39	MP0001485_abnormal_pinna_reflex	1.38357391
40	MP0002876_abnormal_thyroid_physiology	1.38235603
41	MP0000631_abnormal_neuroendocrine_gland	1.37310085
42	MP0006276_abnormal_autonomic_nervous	1.29859037
43	MP0002735_abnormal_chemical_nociception	1.29454777
44	MP0001529_abnormal_vocalization	1.28075890
45	MP0002638_abnormal_pupillary_reflex	1.26678877
46	MP0004133_heterotaxia	1.25203310
47	MP0003693_abnormal_embryo_hatching	1.23447453
48	MP0003567_abnormal_fetal_cardiomyocyte	1.16224797
49	MP0000685_abnormal_immune_system	1.15513531
50	MP0008058_abnormal_DNA_repair	1.12349788
51	MP0003315_abnormal_perineum_morphology	1.11582245
52	MP0000049_abnormal_middle_ear	1.10023964
53	MP0009745_abnormal_behavioral_response	1.09145132
54	MP0002733_abnormal_thermal_nociception	1.09080901
55	MP0003786_premature_aging	1.08594875
56	MP0005075_abnormal_melanosome_morpholog	1.07166209
57	MP0001790_abnormal_immune_system	1.06787484
58	MP0005387_immune_system_phenotype	1.06787484
59	MP0001970_abnormal_pain_threshold	1.05293550
60	MP0000778_abnormal_nervous_system	1.05166077
61	MP0002148_abnormal_hypersensitivity_rea	1.01448786
62	MP0002557_abnormal_social/conspecific_i	0.99593651
63	MP0002234_abnormal_pharynx_morphology	0.99465923
64	MP0005379_endocrine/exocrine_gland_phen	0.98346764
65	MP0008775_abnormal_heart_ventricle	0.95625926
66	MP0001905_abnormal_dopamine_level	0.93549689
67	MP0005253_abnormal_eye_physiology	0.93151073
68	MP0002095_abnormal_skin_pigmentation	0.92744397
69	MP0003283_abnormal_digestive_organ	0.92654623
70	MP0001663_abnormal_digestive_system	0.91774270
71	MP0008995_early_reproductive_senescence	0.89331715
72	MP0005671_abnormal_response_to	0.88292315
73	MP0003195_calcinosis	0.86951225
74	MP0005389_reproductive_system_phenotype	0.86792775
75	MP0003938_abnormal_ear_development	0.86306577
76	MP0005636_abnormal_mineral_homeostasis	0.85558464
77	MP0001919_abnormal_reproductive_system	0.84106716
78	MP0002751_abnormal_autonomic_nervous	0.82579165
79	MP0003890_abnormal_embryonic-extraembry	0.82110598
80	MP0008789_abnormal_olfactory_epithelium	0.81531319
81	MP0005408_hypopigmentation	0.80786288
82	MP0002752_abnormal_somatic_nervous	0.80370679
83	MP0003186_abnormal_redox_activity	0.80315406
84	MP0001963_abnormal_hearing_physiology	0.80199085
85	MP0000026_abnormal_inner_ear	0.79165034
86	MP0009764_decreased_sensitivity_to	0.78476838
87	MP0004019_abnormal_vitamin_homeostasis	0.77413924
88	MP0000538_abnormal_urinary_bladder	0.77199993
89	MP0005167_abnormal_blood-brain_barrier	0.76673885
90	MP0003866_abnormal_defecation	0.76230441
91	MP0005195_abnormal_posterior_eye	0.76009447
92	MP0002210_abnormal_sex_determination	0.75616952
93	MP0001486_abnormal_startle_reflex	0.73254491
94	MP0001800_abnormal_humoral_immune	0.71654242
95	MP0004145_abnormal_muscle_electrophysio	0.70609107
96	MP0009333_abnormal_splenocyte_physiolog	0.70566692
97	MP0002572_abnormal_emotion/affect_behav	0.70385961
98	MP0001440_abnormal_grooming_behavior	0.69916870
99	MP0000427_abnormal_hair_cycle	0.67858598
100	MP0002184_abnormal_innervation	0.67648891

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	3.81529155
2	Acute necrotizing encephalopathy (HP:0006965)	3.73753911
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.43533143
4	Abnormality of midbrain morphology (HP:0002418)	3.34269055
5	Molar tooth sign on MRI (HP:0002419)	3.34269055
6	Nephronophthisis (HP:0000090)	3.34078603
7	Stomatitis (HP:0010280)	3.30801890
8	Pancreatic cysts (HP:0001737)	3.29100483
9	3-Methylglutaconic aciduria (HP:0003535)	3.27132489
10	Acute encephalopathy (HP:0006846)	3.25244822
11	Mitochondrial inheritance (HP:0001427)	3.23950891
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.19924967
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.17271688
14	Pancreatic fibrosis (HP:0100732)	3.12974621
15	Colon cancer (HP:0003003)	3.01541884
16	Increased CSF lactate (HP:0002490)	3.00549247
17	Hepatocellular necrosis (HP:0001404)	2.97410332
18	True hermaphroditism (HP:0010459)	2.93960187
19	Progressive macrocephaly (HP:0004481)	2.92152458
20	Pendular nystagmus (HP:0012043)	2.80231813
21	Abnormality of the renal medulla (HP:0100957)	2.78074434
22	Septo-optic dysplasia (HP:0100842)	2.76737082
23	Increased serum lactate (HP:0002151)	2.70053470
24	Macrocytic anemia (HP:0001972)	2.69389085
25	Absent thumb (HP:0009777)	2.69099476
26	Abnormality of the labia minora (HP:0012880)	2.65915553
27	Abnormality of the pons (HP:0007361)	2.64764035
28	Type II lissencephaly (HP:0007260)	2.64250178
29	Hepatic necrosis (HP:0002605)	2.63559389
30	Increased hepatocellular lipid droplets (HP:0006565)	2.62476103
31	Abnormal number of erythroid precursors (HP:0012131)	2.58622158
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.58600663
33	Chronic hepatic failure (HP:0100626)	2.54474331
34	Lipid accumulation in hepatocytes (HP:0006561)	2.53464503
35	Optic disc pallor (HP:0000543)	2.51386695
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.44127162
37	Absent/shortened dynein arms (HP:0200106)	2.44127162
38	IgG deficiency (HP:0004315)	2.42739915
39	Hypomagnesemia (HP:0002917)	2.42578209
40	Abnormality of the renal cortex (HP:0011035)	2.39185695
41	Increased IgM level (HP:0003496)	2.37464178
42	Type 2 muscle fiber atrophy (HP:0003554)	2.36869592
43	Cerebral edema (HP:0002181)	2.35260489
44	Abnormal respiratory motile cilium morphology (HP:0005938)	2.30938813
45	Abnormal respiratory epithelium morphology (HP:0012253)	2.30938813
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.30872500
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28968947
48	Hypoplasia of the pons (HP:0012110)	2.28080952
49	Abnormality of magnesium homeostasis (HP:0004921)	2.27744530
50	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.23839216
51	Congenital stationary night blindness (HP:0007642)	2.20042986
52	Abnormal rod and cone electroretinograms (HP:0008323)	2.18439340
53	Methylmalonic acidemia (HP:0002912)	2.15372022
54	Increased corneal curvature (HP:0100692)	2.15050815
55	Keratoconus (HP:0000563)	2.15050815
56	Abnormal ciliary motility (HP:0012262)	2.13661214
57	Methylmalonic aciduria (HP:0012120)	2.13116408
58	Optic nerve hypoplasia (HP:0000609)	2.11920752
59	Lactic acidosis (HP:0003128)	2.11178678
60	Tubular atrophy (HP:0000092)	2.10936930
61	Asplenia (HP:0001746)	2.10333076
62	Progressive microcephaly (HP:0000253)	2.10192474
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10024143
64	Abnormality of alanine metabolism (HP:0010916)	2.10024143
65	Hyperalaninemia (HP:0003348)	2.10024143
66	Abolished electroretinogram (ERG) (HP:0000550)	2.07300407
67	Medial flaring of the eyebrow (HP:0010747)	2.06638645
68	Anencephaly (HP:0002323)	1.98695581
69	Sclerocornea (HP:0000647)	1.98017912
70	Lethargy (HP:0001254)	1.97407771
71	Muscle fiber atrophy (HP:0100295)	1.94727191
72	Bile duct proliferation (HP:0001408)	1.93649901
73	Abnormal biliary tract physiology (HP:0012439)	1.93649901
74	Decreased central vision (HP:0007663)	1.92461031
75	Cystic liver disease (HP:0006706)	1.92168661
76	Pallor (HP:0000980)	1.88793525
77	Optic nerve coloboma (HP:0000588)	1.87754542
78	Hypoplasia of the radius (HP:0002984)	1.86932675
79	Rib fusion (HP:0000902)	1.86206989
80	Renal cortical cysts (HP:0000803)	1.84427027
81	Male pseudohermaphroditism (HP:0000037)	1.83983275
82	Ectopic kidney (HP:0000086)	1.82633474
83	Horseshoe kidney (HP:0000085)	1.82572373
84	Delayed CNS myelination (HP:0002188)	1.82170404
85	Polyuria (HP:0000103)	1.81723329
86	Pancytopenia (HP:0001876)	1.81705022
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.81443993
88	Increased serum pyruvate (HP:0003542)	1.81254540
89	Adrenal hypoplasia (HP:0000835)	1.78485827
90	Leukodystrophy (HP:0002415)	1.77638417
91	Attenuation of retinal blood vessels (HP:0007843)	1.75852565
92	Abnormality of the renal collecting system (HP:0004742)	1.75576660
93	Absent septum pellucidum (HP:0001331)	1.74923976
94	Abnormality of the ileum (HP:0001549)	1.74592687
95	Renal Fanconi syndrome (HP:0001994)	1.73927121
96	Abnormal respiratory motile cilium physiology (HP:0012261)	1.73782137
97	Congenital hepatic fibrosis (HP:0002612)	1.72844328
98	Meckel diverticulum (HP:0002245)	1.71553070
99	Polydipsia (HP:0001959)	1.70817659
100	Abnormal drinking behavior (HP:0030082)	1.70817659

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.72989712
2	WNK4	2.95172065
3	ADRBK2	2.65241192
4	ZAK	2.55340093
5	DYRK2	2.52862613
6	TSSK6	2.48538688
7	TXK	2.42524922
8	TRIM28	2.30443824
9	TLK1	2.27513976
10	PINK1	2.23840378
11	GRK1	2.20023428
12	NUAK1	2.13862006
13	PASK	2.07252396
14	BCKDK	2.02151261
15	NEK1	1.80418246
16	TIE1	1.78867117
17	STK39	1.78422113
18	BMPR1B	1.76722891
19	TAF1	1.65162763
20	TEC	1.62673609
21	WNK3	1.61546050
22	MAP4K2	1.56694122
23	MST4	1.53925965
24	VRK1	1.52771240
25	TGFBR1	1.50300942
26	EPHB2	1.50247528
27	MAP4K1	1.44976114
28	CASK	1.37234841
29	MAP2K6	1.31415574
30	EIF2AK3	1.24627467
31	EIF2AK1	1.19267126
32	NME1	1.18898862
33	ITK	1.14959676
34	PBK	1.14007534
35	KIT	1.08151959
36	PRKCG	1.08113290
37	PLK3	1.07323385
38	STK16	1.05459769
39	MKNK1	1.05238978
40	OXSR1	1.02965228
41	TAOK3	1.02108438
42	IKBKB	1.00848729
43	TNIK	1.00029143
44	TYRO3	0.92034990
45	BUB1	0.86027707
46	PIK3CA	0.84131402
47	MKNK2	0.83908410
48	ACVR1B	0.83241931
49	EIF2AK2	0.81504457
50	PRKCQ	0.80321097
51	ADRBK1	0.78555805
52	SRPK1	0.78002738
53	FRK	0.72675367
54	PRKCH	0.72525667
55	PNCK	0.72468351
56	INSRR	0.69446565
57	PHKG2	0.69406187
58	PHKG1	0.69406187
59	PLK2	0.69235578
60	NME2	0.67982491
61	AKT3	0.64652687
62	RPS6KA5	0.64275885
63	BCR	0.64196188
64	MAP2K7	0.63644531
65	BTK	0.59755875
66	CAMK1	0.58821769
67	CSNK2A2	0.58343886
68	IKBKE	0.56945496
69	AURKB	0.54986631
70	MAPK13	0.54245001
71	ATR	0.54006610
72	PRKCE	0.53469882
73	RPS6KA6	0.51907437
74	FES	0.49653796
75	CDK8	0.49280148
76	MAPKAPK5	0.48718854
77	CSNK1G2	0.48706704
78	CAMKK2	0.47544274
79	CAMK2A	0.46863404
80	CSNK1G3	0.46323074
81	PDK2	0.45921977
82	SYK	0.43544996
83	MAPKAPK3	0.43119777
84	PRKACA	0.42536811
85	DYRK3	0.42089321
86	PRKCA	0.41160185
87	CDK19	0.40444376
88	SIK3	0.39925296
89	DAPK2	0.39767274
90	CSNK1A1L	0.38991152
91	PRKCD	0.38385590
92	PAK3	0.38152939
93	CSNK2A1	0.37449829
94	WNK1	0.37430470
95	DAPK1	0.36219566
96	CSNK1G1	0.35552002
97	NEK2	0.35433543
98	CDC7	0.33921956
99	CSNK1E	0.33168396
100	RPS6KC1	0.32368071

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.64160595
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.97848831
3	Proteasome_Homo sapiens_hsa03050	2.97240192
4	Protein export_Homo sapiens_hsa03060	2.75901796
5	RNA polymerase_Homo sapiens_hsa03020	2.60606152
6	Parkinsons disease_Homo sapiens_hsa05012	2.52282912
7	Asthma_Homo sapiens_hsa05310	2.42720745
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.06253753
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.98278156
10	Allograft rejection_Homo sapiens_hsa05330	1.90699649
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82100192
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.78558410
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.77010025
14	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.75379735
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.72847827
16	Basal transcription factors_Homo sapiens_hsa03022	1.69864661
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.68776994
18	RNA degradation_Homo sapiens_hsa03018	1.68518870
19	One carbon pool by folate_Homo sapiens_hsa00670	1.68450543
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68051874
21	Huntingtons disease_Homo sapiens_hsa05016	1.66234532
22	Propanoate metabolism_Homo sapiens_hsa00640	1.62756161
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61828654
24	Alzheimers disease_Homo sapiens_hsa05010	1.58029038
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.47042598
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44704397
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.42586413
28	Homologous recombination_Homo sapiens_hsa03440	1.41763918
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.41111962
30	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34576527
31	Sulfur metabolism_Homo sapiens_hsa00920	1.28820439
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.28685650
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.26658116
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.25147201
35	Mismatch repair_Homo sapiens_hsa03430	1.23745518
36	Base excision repair_Homo sapiens_hsa03410	1.22842521
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.20694610
38	Butanoate metabolism_Homo sapiens_hsa00650	1.20647971
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.20323853
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.15978019
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.10071358
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07967799
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.07405454
44	Graft-versus-host disease_Homo sapiens_hsa05332	1.07311384
45	Fat digestion and absorption_Homo sapiens_hsa04975	1.07111250
46	Caffeine metabolism_Homo sapiens_hsa00232	1.05514199
47	RNA transport_Homo sapiens_hsa03013	1.03680030
48	Phototransduction_Homo sapiens_hsa04744	1.03564210
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.98543970
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97895792
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.97305087
52	Purine metabolism_Homo sapiens_hsa00230	0.96516669
53	Nitrogen metabolism_Homo sapiens_hsa00910	0.91588838
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.91368608
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.90340210
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.89060831
57	Nicotine addiction_Homo sapiens_hsa05033	0.85644865
58	Spliceosome_Homo sapiens_hsa03040	0.85184496
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82149922
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82091133
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80546144
62	Peroxisome_Homo sapiens_hsa04146	0.80323192
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79242017
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78331870
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.76229629
66	DNA replication_Homo sapiens_hsa03030	0.75772111
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.71277859
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68114062
69	Metabolic pathways_Homo sapiens_hsa01100	0.64453097
70	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60102878
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59919330
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59297755
73	Regulation of autophagy_Homo sapiens_hsa04140	0.59172187
74	Insulin secretion_Homo sapiens_hsa04911	0.57951410
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.57931929
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57854186
77	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.57352567
78	Morphine addiction_Homo sapiens_hsa05032	0.57323184
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56108009
80	Retinol metabolism_Homo sapiens_hsa00830	0.55803179
81	Fatty acid degradation_Homo sapiens_hsa00071	0.54191838
82	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.51450103
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.49487062
84	Folate biosynthesis_Homo sapiens_hsa00790	0.47969321
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46325213
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45747947
87	Taste transduction_Homo sapiens_hsa04742	0.45091900
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.44795638
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.43113418
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42933618
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42866659
92	Mineral absorption_Homo sapiens_hsa04978	0.42539471
93	Antigen processing and presentation_Homo sapiens_hsa04612	0.40290991
94	Fatty acid elongation_Homo sapiens_hsa00062	0.39014927
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.37633854
96	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.36739641
97	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35096005
98	Sulfur relay system_Homo sapiens_hsa04122	0.34701121
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.34258552
100	GABAergic synapse_Homo sapiens_hsa04727	0.32700105

EEF1A1P34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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