ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.08300997
2	ATP synthesis coupled proton transport (GO:0015986)	4.88767665
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.88767665
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.44247371
5	preassembly of GPI anchor in ER membrane (GO:0016254)	4.31584442
6	positive regulation of prostaglandin secretion (GO:0032308)	4.20112458
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.04751423
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.97178465
9	mannosylation (GO:0097502)	3.86118119
10	L-fucose catabolic process (GO:0042355)	3.84430557
11	fucose catabolic process (GO:0019317)	3.84430557
12	L-fucose metabolic process (GO:0042354)	3.84430557
13	regulation of regulatory T cell differentiation (GO:0045589)	3.78309656
14	negative regulation of mast cell activation (GO:0033004)	3.52462168
15	water-soluble vitamin biosynthetic process (GO:0042364)	3.50783667
16	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.45066677
17	regulation of prostaglandin secretion (GO:0032306)	3.43771291
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.40609394
19	regulation of activation of Janus kinase activity (GO:0010533)	3.37884083
20	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.35567481
21	regulation of mitotic spindle checkpoint (GO:1903504)	3.35567481
22	maturation of 5.8S rRNA (GO:0000460)	3.34582483
23	rRNA modification (GO:0000154)	3.30246953
24	ribosomal small subunit assembly (GO:0000028)	3.29765509
25	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.29344346
26	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.29344346
27	isotype switching (GO:0045190)	3.29344346
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.26953572
29	termination of RNA polymerase III transcription (GO:0006386)	3.26953572
30	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.26770358
31	proteasome assembly (GO:0043248)	3.26022363
32	tolerance induction (GO:0002507)	3.24545832
33	protein deneddylation (GO:0000338)	3.14325205
34	indole-containing compound catabolic process (GO:0042436)	3.10931069
35	indolalkylamine catabolic process (GO:0046218)	3.10931069
36	tryptophan catabolic process (GO:0006569)	3.10931069
37	positive regulation of defense response to virus by host (GO:0002230)	3.06398848
38	sleep (GO:0030431)	3.05869090
39	protein complex biogenesis (GO:0070271)	3.03553800
40	chaperone-mediated protein transport (GO:0072321)	3.02964967
41	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.01806605
42	positive regulation of fatty acid transport (GO:2000193)	2.97604722
43	respiratory chain complex IV assembly (GO:0008535)	2.97018870
44	rRNA methylation (GO:0031167)	2.96105375
45	cullin deneddylation (GO:0010388)	2.95571808
46	platelet dense granule organization (GO:0060155)	2.95499584
47	kynurenine metabolic process (GO:0070189)	2.94886562
48	peptidyl-histidine modification (GO:0018202)	2.94590729
49	regulation of immunoglobulin secretion (GO:0051023)	2.92722389
50	cytidine deamination (GO:0009972)	2.91102530
51	cytidine metabolic process (GO:0046087)	2.91102530
52	cytidine catabolic process (GO:0006216)	2.91102530
53	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88308332
54	regulation of B cell receptor signaling pathway (GO:0050855)	2.86870018
55	GPI anchor biosynthetic process (GO:0006506)	2.85654794
56	GPI anchor metabolic process (GO:0006505)	2.84240189
57	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.84021331
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.84021331
59	NADH dehydrogenase complex assembly (GO:0010257)	2.84021331
60	signal peptide processing (GO:0006465)	2.83016618
61	regulation of memory T cell differentiation (GO:0043380)	2.80095703
62	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.80043517
63	positive regulation of icosanoid secretion (GO:0032305)	2.79598126
64	C-terminal protein amino acid modification (GO:0018410)	2.79008291
65	behavioral response to nicotine (GO:0035095)	2.76166051
66	indolalkylamine metabolic process (GO:0006586)	2.75570288
67	pseudouridine synthesis (GO:0001522)	2.75466032
68	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75191877
69	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.75142270
70	C-terminal protein lipidation (GO:0006501)	2.73078150
71	electron transport chain (GO:0022900)	2.68380985
72	positive regulation of T-helper 1 type immune response (GO:0002827)	2.67338778
73	regulation of isotype switching to IgG isotypes (GO:0048302)	2.65904971
74	rRNA catabolic process (GO:0016075)	2.65523061
75	regulation of T cell mediated cytotoxicity (GO:0001914)	2.63457003
76	cytochrome complex assembly (GO:0017004)	2.63377296
77	respiratory electron transport chain (GO:0022904)	2.62557106
78	cellular response to interleukin-15 (GO:0071350)	2.62041402
79	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.61838940
80	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.60184071
81	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.60184071
82	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.60184071
83	positive regulation of interleukin-17 production (GO:0032740)	2.58791177
84	mast cell activation (GO:0045576)	2.58769927
85	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.58644864
86	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.56678097
87	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.55296060
88	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.55296060
89	protein-cofactor linkage (GO:0018065)	2.52902015
90	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.52250732
91	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.52250732
92	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.52004396
93	ATP biosynthetic process (GO:0006754)	2.51254328
94	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.50326701
95	cellular response to ATP (GO:0071318)	2.50000004
96	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.49922825
97	oxidative phosphorylation (GO:0006119)	2.49727051
98	translation (GO:0006412)	2.49563202
99	piRNA metabolic process (GO:0034587)	2.48564558
100	regulation of T cell receptor signaling pathway (GO:0050856)	2.48469974

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.16553590
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.02507631
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.77018832
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.58064733
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.44477494
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.41791520
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89322736
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.84020248
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76698623
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.75488369
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.65324353
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.58111640
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.50312755
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.50296747
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.42443646
16	VDR_22108803_ChIP-Seq_LS180_Human	2.41641212
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.41581730
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.21391906
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.17400228
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.15970282
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.09670136
22	EWS_26573619_Chip-Seq_HEK293_Human	2.04088771
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.96371731
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.95529453
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.93501582
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.92588480
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.92528790
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.85075360
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.83914269
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83093142
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.83041284
32	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.82943557
33	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.82755137
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72660228
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68001275
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.66522806
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.59599285
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.59358863
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.59358863
40	GATA3_26560356_Chip-Seq_TH2_Human	1.58658014
41	FUS_26573619_Chip-Seq_HEK293_Human	1.57226110
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54243200
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.52099064
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.49206924
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42811659
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42804025
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.41174202
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.35938339
49	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33149535
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32869317
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30879193
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30879193
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30165536
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29741059
55	AR_20517297_ChIP-Seq_VCAP_Human	1.27528710
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.25592541
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.24204479
58	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.24010281
59	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23397885
60	TTF2_22483619_ChIP-Seq_HELA_Human	1.23288341
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.22429009
62	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.21551940
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21097065
64	P300_19829295_ChIP-Seq_ESCs_Human	1.19231052
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17395346
66	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.15707688
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.14033415
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.11591370
69	RUNX_20019798_ChIP-Seq_JUKART_Human	1.11303806
70	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.09215719
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09145752
72	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.08607872
73	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.07269826
74	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06509333
75	MYB_26560356_Chip-Seq_TH2_Human	1.06119372
76	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03681426
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03495992
78	IGF1R_20145208_ChIP-Seq_DFB_Human	1.02996696
79	CBP_20019798_ChIP-Seq_JUKART_Human	1.02995955
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02995955
81	NCOR_22424771_ChIP-Seq_293T_Human	1.00914670
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00819819
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.00158158
84	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.98511577
85	ER_23166858_ChIP-Seq_MCF-7_Human	0.94589658
86	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93950820
87	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.93501524
88	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92199176
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.91874778
90	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.89977479
91	GATA3_26560356_Chip-Seq_TH1_Human	0.89331177
92	GATA3_27048872_Chip-Seq_THYMUS_Human	0.88611371
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87983183
94	ERG_20517297_ChIP-Seq_VCAP_Human	0.87552800
95	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.87458865
96	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87378365
97	CIITA_25753668_ChIP-Seq_RAJI_Human	0.87313344
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86710353
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86230861
100	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85833968

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.62586841
2	MP0001835_abnormal_antigen_presentation	3.05215685
3	MP0003724_increased_susceptibility_to	2.82095150
4	MP0006072_abnormal_retinal_apoptosis	2.67465001
5	MP0002102_abnormal_ear_morphology	2.66457934
6	MP0008875_abnormal_xenobiotic_pharmacok	2.38679896
7	MP0003718_maternal_effect	2.25190018
8	MP0002166_altered_tumor_susceptibility	2.22613726
9	MP0002148_abnormal_hypersensitivity_rea	2.18884232
10	MP0008877_abnormal_DNA_methylation	2.16540286
11	MP0000685_abnormal_immune_system	2.14359598
12	MP0004147_increased_porphyrin_level	2.04732853
13	MP0005075_abnormal_melanosome_morpholog	2.01603566
14	MP0000372_irregular_coat_pigmentation	1.99313767
15	MP0008872_abnormal_physiological_respon	1.97713423
16	MP0003806_abnormal_nucleotide_metabolis	1.93887376
17	MP0009379_abnormal_foot_pigmentation	1.90898032
18	MP0003763_abnormal_thymus_physiology	1.87997970
19	MP0002006_tumorigenesis	1.87332758
20	MP0005084_abnormal_gallbladder_morpholo	1.84220253
21	MP0001800_abnormal_humoral_immune	1.82496499
22	MP0001986_abnormal_taste_sensitivity	1.81136450
23	MP0005000_abnormal_immune_tolerance	1.81028991
24	MP0005387_immune_system_phenotype	1.72858135
25	MP0001790_abnormal_immune_system	1.72858135
26	MP0004885_abnormal_endolymph	1.72857626
27	MP0002876_abnormal_thyroid_physiology	1.71780259
28	MP0002938_white_spotting	1.68340166
29	MP0009785_altered_susceptibility_to	1.65223211
30	MP0000465_gastrointestinal_hemorrhage	1.63740294
31	MP0002723_abnormal_immune_serum	1.62386045
32	MP0003786_premature_aging	1.55346363
33	MP0002277_abnormal_respiratory_mucosa	1.52338391
34	MP0005174_abnormal_tail_pigmentation	1.51736885
35	MP0003011_delayed_dark_adaptation	1.47649942
36	MP0010155_abnormal_intestine_physiology	1.46553298
37	MP0005253_abnormal_eye_physiology	1.46466846
38	MP0009333_abnormal_splenocyte_physiolog	1.45728329
39	MP0002420_abnormal_adaptive_immunity	1.43615601
40	MP0001819_abnormal_immune_cell	1.43464141
41	MP0002452_abnormal_antigen_presenting	1.39734773
42	MP0005551_abnormal_eye_electrophysiolog	1.37086690
43	MP0009764_decreased_sensitivity_to	1.35335002
44	MP0005085_abnormal_gallbladder_physiolo	1.33259948
45	MP0008058_abnormal_DNA_repair	1.30616632
46	MP0006036_abnormal_mitochondrial_physio	1.27452649
47	MP0003195_calcinosis	1.20738266
48	MP0001873_stomach_inflammation	1.19353233
49	MP0003646_muscle_fatigue	1.18047840
50	MP0002398_abnormal_bone_marrow	1.17328974
51	MP0001845_abnormal_inflammatory_respons	1.15905970
52	MP0003866_abnormal_defecation	1.15780424
53	MP0006035_abnormal_mitochondrial_morpho	1.15579361
54	MP0006292_abnormal_olfactory_placode	1.13567980
55	MP0005645_abnormal_hypothalamus_physiol	1.13124352
56	MP0000689_abnormal_spleen_morphology	1.12975317
57	MP0004782_abnormal_surfactant_physiolog	1.10861171
58	MP0002138_abnormal_hepatobiliary_system	1.09730535
59	MP0010094_abnormal_chromosome_stability	1.08224839
60	MP0000716_abnormal_immune_system	1.08132129
61	MP0005360_urolithiasis	1.07157547
62	MP0003638_abnormal_response/metabolism_	1.04943101
63	MP0005025_abnormal_response_to	1.04079721
64	MP0005377_hearing/vestibular/ear_phenot	1.02143020
65	MP0003878_abnormal_ear_physiology	1.02143020
66	MP0003436_decreased_susceptibility_to	0.98812964
67	MP0002736_abnormal_nociception_after	0.98059415
68	MP0002405_respiratory_system_inflammati	0.97945770
69	MP0000569_abnormal_digit_pigmentation	0.97835169
70	MP0004019_abnormal_vitamin_homeostasis	0.96819124
71	MP0002095_abnormal_skin_pigmentation	0.96181216
72	MP0001666_abnormal_nutrient_absorption	0.95782800
73	MP0001533_abnormal_skeleton_physiology	0.95683078
74	MP0002163_abnormal_gland_morphology	0.95336003
75	MP0008775_abnormal_heart_ventricle	0.94733929
76	MP0002429_abnormal_blood_cell	0.93652013
77	MP0005332_abnormal_amino_acid	0.91386545
78	MP0001968_abnormal_touch/_nociception	0.90487739
79	MP0003693_abnormal_embryo_hatching	0.90356547
80	MP0008469_abnormal_protein_level	0.89465402
81	MP0002722_abnormal_immune_system	0.87895597
82	MP0005365_abnormal_bile_salt	0.82995084
83	MP0004142_abnormal_muscle_tone	0.82291407
84	MP0000703_abnormal_thymus_morphology	0.81951936
85	MP0005636_abnormal_mineral_homeostasis	0.81400505
86	MP0000490_abnormal_crypts_of	0.81213874
87	MP0001919_abnormal_reproductive_system	0.81046043
88	MP0002009_preneoplasia	0.80089951
89	MP0004957_abnormal_blastocyst_morpholog	0.79317566
90	MP0001501_abnormal_sleep_pattern	0.78007280
91	MP0002234_abnormal_pharynx_morphology	0.75011528
92	MP0008007_abnormal_cellular_replicative	0.73955900
93	MP0001293_anophthalmia	0.73250157
94	MP0006276_abnormal_autonomic_nervous	0.73069547
95	MP0001661_extended_life_span	0.72886471
96	MP0009643_abnormal_urine_homeostasis	0.72645300
97	MP0003252_abnormal_bile_duct	0.72567766
98	MP0001905_abnormal_dopamine_level	0.71689470
99	MP0002419_abnormal_innate_immunity	0.70839011
100	MP0005389_reproductive_system_phenotype	0.70172137

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.26698211
2	IgG deficiency (HP:0004315)	3.99282287
3	Congenital, generalized hypertrichosis (HP:0004540)	3.79335046
4	Stomatitis (HP:0010280)	3.41859858
5	Increased CSF lactate (HP:0002490)	3.33349367
6	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.31369161
7	Mitochondrial inheritance (HP:0001427)	3.29491383
8	Acute necrotizing encephalopathy (HP:0006965)	3.28337966
9	Abnormality of the renal cortex (HP:0011035)	3.28060844
10	Hepatocellular necrosis (HP:0001404)	3.15109496
11	Increased IgM level (HP:0003496)	3.12119110
12	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.03126889
13	Congenital stationary night blindness (HP:0007642)	2.98082502
14	Pancreatic cysts (HP:0001737)	2.93599875
15	Acute encephalopathy (HP:0006846)	2.88227296
16	Bile duct proliferation (HP:0001408)	2.87535227
17	Abnormal biliary tract physiology (HP:0012439)	2.87535227
18	Progressive macrocephaly (HP:0004481)	2.85726866
19	Increased hepatocellular lipid droplets (HP:0006565)	2.83519168
20	Hepatic necrosis (HP:0002605)	2.78937156
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.71788414
22	Pancreatic fibrosis (HP:0100732)	2.71470005
23	IgM deficiency (HP:0002850)	2.68214513
24	Increased serum lactate (HP:0002151)	2.61982474
25	Abnormality of T cells (HP:0002843)	2.61729716
26	Lipid accumulation in hepatocytes (HP:0006561)	2.61699525
27	Dyschromatopsia (HP:0007641)	2.60587921
28	Hypothermia (HP:0002045)	2.59668245
29	Abnormality of T cell physiology (HP:0011840)	2.59308683
30	Nephronophthisis (HP:0000090)	2.56185781
31	Abolished electroretinogram (ERG) (HP:0000550)	2.53719902
32	True hermaphroditism (HP:0010459)	2.52370363
33	Abnormality of T cell number (HP:0011839)	2.46630478
34	Progressive inability to walk (HP:0002505)	2.46205153
35	Polydipsia (HP:0001959)	2.43538927
36	Abnormal drinking behavior (HP:0030082)	2.43538927
37	Renal cortical cysts (HP:0000803)	2.40837108
38	Molar tooth sign on MRI (HP:0002419)	2.33520388
39	Abnormality of midbrain morphology (HP:0002418)	2.33520388
40	Chronic hepatic failure (HP:0100626)	2.31105888
41	Cerebral edema (HP:0002181)	2.30458710
42	Optic disc pallor (HP:0000543)	2.30123198
43	Parakeratosis (HP:0001036)	2.28860753
44	Abnormality of B cell number (HP:0010975)	2.27836388
45	Tubular atrophy (HP:0000092)	2.26496479
46	Elevated erythrocyte sedimentation rate (HP:0003565)	2.25777469
47	Retrobulbar optic neuritis (HP:0100654)	2.23860153
48	Optic neuritis (HP:0100653)	2.23860153
49	Abnormality of the renal medulla (HP:0100957)	2.23707386
50	Polyuria (HP:0000103)	2.21412327
51	Inability to walk (HP:0002540)	2.16807625
52	Renal Fanconi syndrome (HP:0001994)	2.15934559
53	Constricted visual fields (HP:0001133)	2.14275294
54	Testicular atrophy (HP:0000029)	2.12946730
55	Hypoproteinemia (HP:0003075)	2.12592874
56	T lymphocytopenia (HP:0005403)	2.10848077
57	Methylmalonic acidemia (HP:0002912)	2.10737900
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.10514639
59	Lethargy (HP:0001254)	2.09415965
60	Hyperglycinuria (HP:0003108)	2.08927860
61	Lactic acidosis (HP:0003128)	2.06564368
62	Tubulointerstitial fibrosis (HP:0005576)	2.06458779
63	Conical tooth (HP:0000698)	2.05728780
64	Pancytopenia (HP:0001876)	2.04249051
65	Hypoplasia of the uterus (HP:0000013)	2.03163176
66	Stomach cancer (HP:0012126)	2.01855160
67	Abnormal number of erythroid precursors (HP:0012131)	1.97893389
68	Severe combined immunodeficiency (HP:0004430)	1.97643109
69	Myositis (HP:0100614)	1.96987635
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.96856628
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.96856628
72	Abnormality of eosinophils (HP:0001879)	1.96848129
73	Metabolic alkalosis (HP:0200114)	1.95161196
74	Abnormality of urine glucose concentration (HP:0011016)	1.95041991
75	Glycosuria (HP:0003076)	1.95041991
76	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.92702608
77	Chronic diarrhea (HP:0002028)	1.92639807
78	Sensory axonal neuropathy (HP:0003390)	1.92255227
79	Decreased circulating renin level (HP:0003351)	1.91665688
80	Spastic paraparesis (HP:0002313)	1.89872442
81	Abnormal rod and cone electroretinograms (HP:0008323)	1.89691201
82	Meckel diverticulum (HP:0002245)	1.89604852
83	Type II lissencephaly (HP:0007260)	1.88813434
84	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.87175743
85	Leukodystrophy (HP:0002415)	1.86414809
86	Attenuation of retinal blood vessels (HP:0007843)	1.86212480
87	B lymphocytopenia (HP:0010976)	1.86137652
88	Abnormality of the pons (HP:0007361)	1.85836311
89	Abnormal urine output (HP:0012590)	1.85526694
90	Abnormality of the prostate (HP:0008775)	1.84594534
91	Abnormality of the ileum (HP:0001549)	1.84435907
92	Exertional dyspnea (HP:0002875)	1.83108095
93	IgA deficiency (HP:0002720)	1.82257475
94	Methylmalonic aciduria (HP:0012120)	1.82001639
95	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.81409649
96	Clubbing of toes (HP:0100760)	1.80265826
97	Paralysis (HP:0003470)	1.80075415
98	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.78658153
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78264380
100	Abnormality of glycine metabolism (HP:0010895)	1.78264380

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.39553620
2	TXK	3.59037302
3	TAOK3	3.45587891
4	ZAK	3.13386715
5	TLK1	3.12279625
6	NUAK1	3.01857417
7	MAP4K2	2.74185061
8	TRIM28	2.51119021
9	TSSK6	2.26455123
10	VRK2	2.19661961
11	TIE1	2.18757280
12	MAP4K1	2.17935150
13	EIF2AK3	2.15463544
14	MAP3K12	2.05656896
15	ADRBK2	2.01558978
16	VRK1	1.99871837
17	GRK1	1.76927784
18	BCKDK	1.66364514
19	FRK	1.57755798
20	BUB1	1.50773749
21	ERBB3	1.48697509
22	MAP2K2	1.47570440
23	PLK3	1.41436664
24	ACVR1B	1.39899622
25	PNCK	1.38265241
26	SRPK1	1.34668096
27	PLK4	1.34036591
28	GRK6	1.32935526
29	EIF2AK1	1.30079305
30	TEC	1.29874415
31	MAP3K14	1.29083361
32	NEK1	1.27116200
33	IKBKB	1.24486721
34	PASK	1.23611148
35	LIMK1	1.15013032
36	WNK3	1.12935425
37	CDK8	1.12042821
38	TNIK	1.10467150
39	KIT	1.04740688
40	MAPK15	1.04500120
41	TGFBR1	1.00373213
42	BCR	0.94260065
43	FES	0.93365014
44	MAP2K6	0.92616275
45	BMPR1B	0.91267222
46	MAPKAPK3	0.91103820
47	TAF1	0.90510727
48	OXSR1	0.85408465
49	SIK3	0.83126471
50	MYLK	0.78337372
51	PLK2	0.75426799
52	WNK4	0.75086757
53	ITK	0.74668271
54	BMPR2	0.73421137
55	SYK	0.70069647
56	EIF2AK2	0.69315314
57	IKBKE	0.69109418
58	TGFBR2	0.68870088
59	STK16	0.66652676
60	WEE1	0.66144036
61	MKNK1	0.64284340
62	KDR	0.63931146
63	NME1	0.63515270
64	CSF1R	0.61173675
65	MAPKAPK5	0.60325718
66	LYN	0.56723450
67	TBK1	0.54889265
68	INSRR	0.53604137
69	ADRBK1	0.51183903
70	ATR	0.49909393
71	PRKCQ	0.48107659
72	CDC7	0.44845141
73	BTK	0.44626787
74	CDK19	0.44108550
75	MUSK	0.43250121
76	FLT3	0.42988641
77	GRK5	0.42795326
78	LCK	0.42736396
79	IGF1R	0.42245634
80	RPS6KB2	0.41644403
81	AURKB	0.41000861
82	PIM1	0.40402285
83	STK10	0.38565184
84	CHUK	0.38185692
85	DYRK2	0.36896023
86	MKNK2	0.35320832
87	CSNK2A2	0.35127959
88	CSNK2A1	0.33414529
89	ZAP70	0.33405842
90	RPS6KA5	0.32499619
91	PHKG2	0.32377037
92	PHKG1	0.32377037
93	GRK7	0.31227678
94	CLK1	0.29836449
95	TTK	0.29434038
96	STK39	0.28005521
97	CDC42BPA	0.27790528
98	ALK	0.26908875
99	PIK3CA	0.26824703
100	BRSK2	0.26330082

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.22463804
2	Asthma_Homo sapiens_hsa05310	3.05488951
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.00743560
4	Allograft rejection_Homo sapiens_hsa05330	2.79601626
5	Caffeine metabolism_Homo sapiens_hsa00232	2.73639193
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.54997303
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.54871951
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.54859450
9	Ribosome_Homo sapiens_hsa03010	2.44604430
10	RNA polymerase_Homo sapiens_hsa03020	2.41310040
11	Protein export_Homo sapiens_hsa03060	2.41253205
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34757672
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.22905679
14	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.19880841
15	Parkinsons disease_Homo sapiens_hsa05012	2.06059632
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.96591634
17	RNA degradation_Homo sapiens_hsa03018	1.90203135
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.84890810
19	Basal transcription factors_Homo sapiens_hsa03022	1.75850290
20	One carbon pool by folate_Homo sapiens_hsa00670	1.72831640
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.63839746
22	Sulfur metabolism_Homo sapiens_hsa00920	1.60234639
23	Phototransduction_Homo sapiens_hsa04744	1.56307303
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50616751
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.48986694
26	Rheumatoid arthritis_Homo sapiens_hsa05323	1.32745742
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29296889
28	Alzheimers disease_Homo sapiens_hsa05010	1.25157409
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.24529972
30	Huntingtons disease_Homo sapiens_hsa05016	1.21410596
31	Homologous recombination_Homo sapiens_hsa03440	1.20706850
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.17068615
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.16379770
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14129748
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13346032
36	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.11778439
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.10376663
38	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.09917686
39	Propanoate metabolism_Homo sapiens_hsa00640	1.07982926
40	Mismatch repair_Homo sapiens_hsa03430	1.05490410
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02822776
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.02367462
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.01357406
44	Spliceosome_Homo sapiens_hsa03040	1.01139544
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.96705287
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95946005
47	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.95085342
48	Purine metabolism_Homo sapiens_hsa00230	0.94602604
49	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.93388232
50	Non-homologous end-joining_Homo sapiens_hsa03450	0.92009843
51	RNA transport_Homo sapiens_hsa03013	0.91787860
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.91364906
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.90924222
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90390854
55	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.86897997
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.86398977
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83860698
58	Viral myocarditis_Homo sapiens_hsa05416	0.81949980
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79291356
60	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.77752270
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.76969989
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.74186258
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74180562
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.72916313
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71476794
66	Herpes simplex infection_Homo sapiens_hsa05168	0.70207412
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67064882
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.65530662
69	DNA replication_Homo sapiens_hsa03030	0.62825826
70	Butanoate metabolism_Homo sapiens_hsa00650	0.62291858
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.62043975
72	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61820256
73	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61679560
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60102025
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59890528
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.59518357
77	Retinol metabolism_Homo sapiens_hsa00830	0.59311491
78	Leishmaniasis_Homo sapiens_hsa05140	0.58282936
79	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.58158275
80	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57131562
81	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56896273
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53977210
83	Glutathione metabolism_Homo sapiens_hsa00480	0.52867673
84	Peroxisome_Homo sapiens_hsa04146	0.52515534
85	Regulation of autophagy_Homo sapiens_hsa04140	0.52129153
86	Metabolic pathways_Homo sapiens_hsa01100	0.50859904
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49739912
88	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.49667998
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.48564839
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.48404201
91	Legionellosis_Homo sapiens_hsa05134	0.47496126
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.45327521
93	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40320090
94	Collecting duct acid secretion_Homo sapiens_hsa04966	0.39211087
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36746509
96	Measles_Homo sapiens_hsa05162	0.35619172
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32631664
98	Fatty acid elongation_Homo sapiens_hsa00062	0.32563126
99	Base excision repair_Homo sapiens_hsa03410	0.30191415
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27041675

EEF1A1P36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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