EEF1A1P38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.27388789
2ribosomal small subunit assembly (GO:0000028)5.14660448
3ATP synthesis coupled proton transport (GO:0015986)4.85448639
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.85448639
5water-soluble vitamin biosynthetic process (GO:0042364)4.36657368
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.31368458
7tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.10024110
8RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.10024110
9protein complex biogenesis (GO:0070271)3.78871157
10viral transcription (GO:0019083)3.77095813
11maturation of SSU-rRNA (GO:0030490)3.67251939
12translational termination (GO:0006415)3.63570716
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59489513
14ribosomal large subunit biogenesis (GO:0042273)3.57167324
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.55671986
16chaperone-mediated protein transport (GO:0072321)3.55625292
17cotranslational protein targeting to membrane (GO:0006613)3.52700585
18protein targeting to ER (GO:0045047)3.50380197
19proteasome assembly (GO:0043248)3.50066043
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.49159165
21NADH dehydrogenase complex assembly (GO:0010257)3.49159165
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.49159165
23mitochondrial respiratory chain complex assembly (GO:0033108)3.46394957
24behavioral response to nicotine (GO:0035095)3.45185584
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43360936
26translational elongation (GO:0006414)3.42291473
27L-fucose catabolic process (GO:0042355)3.36752199
28fucose catabolic process (GO:0019317)3.36752199
29L-fucose metabolic process (GO:0042354)3.36752199
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.34845046
31protein localization to endoplasmic reticulum (GO:0070972)3.34573026
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.32112165
33platelet dense granule organization (GO:0060155)3.31944080
34regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.31632508
35GTP biosynthetic process (GO:0006183)3.29756126
36protein neddylation (GO:0045116)3.26580561
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.23113797
38cytidine deamination (GO:0009972)3.21279017
39cytidine metabolic process (GO:0046087)3.21279017
40cytidine catabolic process (GO:0006216)3.21279017
41respiratory chain complex IV assembly (GO:0008535)3.19994346
42electron transport chain (GO:0022900)3.12122932
43respiratory electron transport chain (GO:0022904)3.11396594
44translation (GO:0006412)3.06208592
45termination of RNA polymerase III transcription (GO:0006386)3.05609308
46transcription elongation from RNA polymerase III promoter (GO:0006385)3.05609308
47positive regulation of prostaglandin secretion (GO:0032308)3.04864204
48regulation of cellular amino acid metabolic process (GO:0006521)3.04438722
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94026739
50pyrimidine ribonucleoside catabolic process (GO:0046133)2.89473331
51positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.87574866
52purine nucleoside triphosphate biosynthetic process (GO:0009145)2.87031366
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86151481
54positive regulation of defense response to virus by host (GO:0002230)2.85399277
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.84721818
56regulation of isotype switching to IgG isotypes (GO:0048302)2.84626800
57cytochrome complex assembly (GO:0017004)2.84615327
58rRNA modification (GO:0000154)2.83684289
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83589561
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83589561
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83589561
62translational initiation (GO:0006413)2.82465778
63cullin deneddylation (GO:0010388)2.82311414
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80530971
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80530971
66response to pheromone (GO:0019236)2.79836126
67regulation of regulatory T cell differentiation (GO:0045589)2.77786782
68regulation of immunoglobulin secretion (GO:0051023)2.77783583
69viral life cycle (GO:0019058)2.77512032
70pseudouridine synthesis (GO:0001522)2.75328384
71protein deneddylation (GO:0000338)2.74688351
72ATP biosynthetic process (GO:0006754)2.72381593
73tRNA processing (GO:0008033)2.68437187
74signal transduction involved in DNA damage checkpoint (GO:0072422)2.67098921
75signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67098921
76proton transport (GO:0015992)2.66173833
77hydrogen ion transmembrane transport (GO:1902600)2.64555213
78signal transduction involved in cell cycle checkpoint (GO:0072395)2.63598328
79UTP metabolic process (GO:0046051)2.63478194
80cellular protein complex disassembly (GO:0043624)2.63364573
81positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63295768
82hydrogen transport (GO:0006818)2.62040226
83cellular component biogenesis (GO:0044085)2.60881138
84regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.60011843
85peptidyl-histidine modification (GO:0018202)2.59936153
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59219776
87UTP biosynthetic process (GO:0006228)2.58724171
88signal peptide processing (GO:0006465)2.58523000
89preassembly of GPI anchor in ER membrane (GO:0016254)2.57926774
90protein-cofactor linkage (GO:0018065)2.56548330
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56000760
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.55926039
93positive regulation of fatty acid transport (GO:2000193)2.53001971
94maturation of 5.8S rRNA (GO:0000460)2.48625570
95ribonucleoside triphosphate biosynthetic process (GO:0009201)2.48337308
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.47158214
97negative regulation of ligase activity (GO:0051352)2.47158214
98rRNA processing (GO:0006364)2.46394202
99rRNA metabolic process (GO:0016072)2.46238214
100negative regulation of telomere maintenance (GO:0032205)2.46169383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.31683747
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06238603
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.82998023
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.40821816
5VDR_22108803_ChIP-Seq_LS180_Human3.26924578
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93886722
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91362244
8ZNF274_21170338_ChIP-Seq_K562_Hela2.75749024
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74485907
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.53565912
11VDR_23849224_ChIP-Seq_CD4+_Human2.52012990
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.40473337
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.25178025
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20478763
15ELK1_19687146_ChIP-ChIP_HELA_Human2.19475300
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16736233
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05044168
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01464535
19FOXP3_21729870_ChIP-Seq_TREG_Human2.00641852
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.95542531
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.95259935
22MYC_18940864_ChIP-ChIP_HL60_Human1.89151454
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81621965
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80054528
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76872283
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68741030
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68270772
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63044923
29TP53_22573176_ChIP-Seq_HFKS_Human1.61547721
30PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59068157
31IRF1_19129219_ChIP-ChIP_H3396_Human1.55907422
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.52485555
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52009224
34EWS_26573619_Chip-Seq_HEK293_Human1.50866491
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.46761774
36IGF1R_20145208_ChIP-Seq_DFB_Human1.45392015
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.44527102
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44527102
39AR_20517297_ChIP-Seq_VCAP_Human1.42464490
40FUS_26573619_Chip-Seq_HEK293_Human1.42061496
41MYC_18555785_ChIP-Seq_MESCs_Mouse1.36837361
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34685769
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33314234
44NANOG_19829295_ChIP-Seq_ESCs_Human1.31536734
45SOX2_19829295_ChIP-Seq_ESCs_Human1.31536734
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29863154
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28172365
48GATA3_26560356_Chip-Seq_TH2_Human1.28089054
49NANOG_20526341_ChIP-Seq_ESCs_Human1.27622983
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27523623
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.27373994
52TTF2_22483619_ChIP-Seq_HELA_Human1.26301634
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.25361300
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21628770
55P300_19829295_ChIP-Seq_ESCs_Human1.18502302
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18078508
57NCOR_22424771_ChIP-Seq_293T_Human1.17457067
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17192704
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16713022
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.16623140
61MYC_19829295_ChIP-Seq_ESCs_Human1.16203815
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.15886307
63CBP_20019798_ChIP-Seq_JUKART_Human1.15163812
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15163812
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14857988
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14609268
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14160453
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13871484
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13752430
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13501281
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.13095754
72HOXB7_26014856_ChIP-Seq_BT474_Human1.12085806
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11362983
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10812600
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09599702
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09115519
77GABP_19822575_ChIP-Seq_HepG2_Human1.08786960
78ERA_21632823_ChIP-Seq_H3396_Human1.08510323
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05308319
80ER_23166858_ChIP-Seq_MCF-7_Human1.04657358
81TAF2_19829295_ChIP-Seq_ESCs_Human1.03091651
82TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02869187
83SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02207054
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01810691
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01739960
86EZH2_22144423_ChIP-Seq_EOC_Human1.01430906
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98984206
88P53_21459846_ChIP-Seq_SAOS-2_Human0.98690512
89RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98024569
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97947829
91BCAT_22108803_ChIP-Seq_LS180_Human0.97655066
92CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97581735
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96865029
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95988814
95NFE2_27457419_Chip-Seq_LIVER_Mouse0.95521182
96IRF8_21731497_ChIP-ChIP_J774_Mouse0.91875922
97ERG_20517297_ChIP-Seq_VCAP_Human0.91246509
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90407115
99TCF4_22108803_ChIP-Seq_LS180_Human0.90369429
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89536552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.40458338
2MP0001835_abnormal_antigen_presentation3.10203337
3MP0002138_abnormal_hepatobiliary_system3.03617124
4MP0009379_abnormal_foot_pigmentation2.95374980
5MP0005360_urolithiasis2.64490551
6MP0002102_abnormal_ear_morphology2.46373576
7MP0006292_abnormal_olfactory_placode2.38297401
8MP0008872_abnormal_physiological_respon2.25763519
9MP0006072_abnormal_retinal_apoptosis2.13919887
10MP0008875_abnormal_xenobiotic_pharmacok2.12138051
11MP0004147_increased_porphyrin_level2.11457543
12MP0000685_abnormal_immune_system2.02722815
13MP0001873_stomach_inflammation1.97906747
14MP0002148_abnormal_hypersensitivity_rea1.89604753
15MP0001986_abnormal_taste_sensitivity1.88308748
16MP0008877_abnormal_DNA_methylation1.88057942
17MP0005645_abnormal_hypothalamus_physiol1.83208327
18MP0009785_altered_susceptibility_to1.74185748
19MP0005084_abnormal_gallbladder_morpholo1.71885458
20MP0003806_abnormal_nucleotide_metabolis1.70826755
21MP0003195_calcinosis1.66689381
22MP0001800_abnormal_humoral_immune1.65485569
23MP0001968_abnormal_touch/_nociception1.64562139
24MP0001790_abnormal_immune_system1.59269092
25MP0005387_immune_system_phenotype1.59269092
26MP0002876_abnormal_thyroid_physiology1.58485631
27MP0002736_abnormal_nociception_after1.57591681
28MP0000372_irregular_coat_pigmentation1.54488116
29MP0005551_abnormal_eye_electrophysiolog1.49926318
30MP0002837_dystrophic_cardiac_calcinosis1.48948564
31MP0003718_maternal_effect1.47767622
32MP0005085_abnormal_gallbladder_physiolo1.46839706
33MP0010155_abnormal_intestine_physiology1.46764582
34MP0004145_abnormal_muscle_electrophysio1.46708826
35MP0005646_abnormal_pituitary_gland1.46115122
36MP0005075_abnormal_melanosome_morpholog1.40377821
37MP0005377_hearing/vestibular/ear_phenot1.40142183
38MP0003878_abnormal_ear_physiology1.40142183
39MP0009333_abnormal_splenocyte_physiolog1.36555533
40MP0002277_abnormal_respiratory_mucosa1.35624389
41MP0004142_abnormal_muscle_tone1.35390216
42MP0004885_abnormal_endolymph1.34787495
43MP0005000_abnormal_immune_tolerance1.34471773
44MP0003866_abnormal_defecation1.32413616
45MP0009764_decreased_sensitivity_to1.31838864
46MP0002166_altered_tumor_susceptibility1.30586327
47MP0001905_abnormal_dopamine_level1.29584625
48MP0003646_muscle_fatigue1.29380145
49MP0003724_increased_susceptibility_to1.28579957
50MP0003011_delayed_dark_adaptation1.27532487
51MP0008789_abnormal_olfactory_epithelium1.27232000
52MP0002723_abnormal_immune_serum1.26551871
53MP0004019_abnormal_vitamin_homeostasis1.24440805
54MP0002163_abnormal_gland_morphology1.24158920
55MP0003186_abnormal_redox_activity1.21833552
56MP0006036_abnormal_mitochondrial_physio1.18324933
57MP0005365_abnormal_bile_salt1.18240867
58MP0002006_tumorigenesis1.15666471
59MP0005253_abnormal_eye_physiology1.13989039
60MP0002452_abnormal_antigen_presenting1.13559920
61MP0001666_abnormal_nutrient_absorption1.12956943
62MP0003880_abnormal_central_pattern1.11368298
63MP0001819_abnormal_immune_cell1.09903722
64MP0001501_abnormal_sleep_pattern1.09855565
65MP0002095_abnormal_skin_pigmentation1.09071395
66MP0005332_abnormal_amino_acid1.08597132
67MP0002420_abnormal_adaptive_immunity1.07743993
68MP0001764_abnormal_homeostasis1.07632208
69MP0005636_abnormal_mineral_homeostasis1.05794447
70MP0001293_anophthalmia1.05495489
71MP0002653_abnormal_ependyma_morphology1.04807467
72MP0002272_abnormal_nervous_system1.02061074
73MP0002938_white_spotting1.01051350
74MP0001845_abnormal_inflammatory_respons1.00249097
75MP0008775_abnormal_heart_ventricle0.99721202
76MP0009643_abnormal_urine_homeostasis0.99621492
77MP0001485_abnormal_pinna_reflex0.99191358
78MP0001984_abnormal_olfaction0.97710068
79MP0002234_abnormal_pharynx_morphology0.94245268
80MP0003786_premature_aging0.93647593
81MP0001663_abnormal_digestive_system0.91662348
82MP0001765_abnormal_ion_homeostasis0.89593171
83MP0005379_endocrine/exocrine_gland_phen0.88445949
84MP0006276_abnormal_autonomic_nervous0.88140098
85MP0000631_abnormal_neuroendocrine_gland0.83989077
86MP0005389_reproductive_system_phenotype0.83021639
87MP0001529_abnormal_vocalization0.82773443
88MP0000427_abnormal_hair_cycle0.82695700
89MP0008058_abnormal_DNA_repair0.82348026
90MP0002693_abnormal_pancreas_physiology0.81105118
91MP0005025_abnormal_response_to0.80381838
92MP0002638_abnormal_pupillary_reflex0.79037129
93MP0005410_abnormal_fertilization0.78470137
94MP0003252_abnormal_bile_duct0.78423206
95MP0002933_joint_inflammation0.77998984
96MP0001756_abnormal_urination0.76254229
97MP0000716_abnormal_immune_system0.74501716
98MP0000230_abnormal_systemic_arterial0.74292889
99MP0000538_abnormal_urinary_bladder0.73819071
100MP0008469_abnormal_protein_level0.73597108

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.95973796
2Mitochondrial inheritance (HP:0001427)3.80312221
3Acute encephalopathy (HP:0006846)3.59096856
4Increased CSF lactate (HP:0002490)3.53414228
5Pancreatic cysts (HP:0001737)3.53071319
6Abnormal mitochondria in muscle tissue (HP:0008316)3.50467624
7Increased hepatocellular lipid droplets (HP:0006565)3.47496265
8Hepatocellular necrosis (HP:0001404)3.47385542
9Hepatic necrosis (HP:0002605)3.34246240
10Pancreatic fibrosis (HP:0100732)3.32227494
11Lipid accumulation in hepatocytes (HP:0006561)3.30505031
12Progressive macrocephaly (HP:0004481)3.29733383
13Congenital stationary night blindness (HP:0007642)3.20824686
143-Methylglutaconic aciduria (HP:0003535)3.17795557
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98382264
16Methylmalonic acidemia (HP:0002912)2.98238112
17Congenital, generalized hypertrichosis (HP:0004540)2.96279234
18IgG deficiency (HP:0004315)2.93152609
19Abnormality of cells of the erythroid lineage (HP:0012130)2.89873432
20True hermaphroditism (HP:0010459)2.86884003
21Methylmalonic aciduria (HP:0012120)2.84060467
22Abnormality of the renal cortex (HP:0011035)2.81534891
23Increased serum lactate (HP:0002151)2.81200860
24Reticulocytopenia (HP:0001896)2.79221006
25Abnormal number of erythroid precursors (HP:0012131)2.76745764
26Cerebral edema (HP:0002181)2.75860447
27Nephronophthisis (HP:0000090)2.73029990
28Abolished electroretinogram (ERG) (HP:0000550)2.71425771
29Abnormality of midbrain morphology (HP:0002418)2.69065193
30Molar tooth sign on MRI (HP:0002419)2.69065193
31Type II lissencephaly (HP:0007260)2.66511589
32Abnormality of urine glucose concentration (HP:0011016)2.66390169
33Glycosuria (HP:0003076)2.66390169
34Stomatitis (HP:0010280)2.65217954
35Renal Fanconi syndrome (HP:0001994)2.63097753
36Elevated erythrocyte sedimentation rate (HP:0003565)2.62131487
37Increased intramyocellular lipid droplets (HP:0012240)2.61115757
38Abnormality of the vitamin B12 metabolism (HP:0004341)2.54301031
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53752436
40Abnormality of vitamin B metabolism (HP:0004340)2.49318865
41Lactic acidosis (HP:0003128)2.47217203
42Optic disc pallor (HP:0000543)2.45514374
43Renal cortical cysts (HP:0000803)2.44046544
44Lethargy (HP:0001254)2.42045417
45Abnormality of the renal medulla (HP:0100957)2.40572955
46Abnormality of alanine metabolism (HP:0010916)2.37735969
47Hyperalaninemia (HP:0003348)2.37735969
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37735969
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28688157
50Exertional dyspnea (HP:0002875)2.28031986
51Abnormality of the prostate (HP:0008775)2.26472887
52Hyperglycinemia (HP:0002154)2.22772763
53Pendular nystagmus (HP:0012043)2.22275602
54Medial flaring of the eyebrow (HP:0010747)2.18723971
55Increased muscle lipid content (HP:0009058)2.18134170
56Bile duct proliferation (HP:0001408)2.16373679
57Abnormal biliary tract physiology (HP:0012439)2.16373679
58Macrocytic anemia (HP:0001972)2.15436851
59Aplasia/hypoplasia of the uterus (HP:0008684)2.14186195
60Hypoproteinemia (HP:0003075)2.14141263
61Hyperphosphaturia (HP:0003109)2.10915703
62Abnormality of serum amino acid levels (HP:0003112)2.10512699
63Dicarboxylic aciduria (HP:0003215)2.08463027
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.08463027
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.06640161
66Cystic liver disease (HP:0006706)2.06220021
67Abnormal drinking behavior (HP:0030082)2.06042587
68Polydipsia (HP:0001959)2.06042587
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05704044
70Increased IgM level (HP:0003496)2.01253347
71Generalized aminoaciduria (HP:0002909)2.00746505
72Abnormal rod and cone electroretinograms (HP:0008323)2.00653863
73Abnormality of serine family amino acid metabolism (HP:0010894)1.98497725
74Abnormality of glycine metabolism (HP:0010895)1.98497725
75Colon cancer (HP:0003003)1.98195255
76Hypothermia (HP:0002045)1.96744673
77Hyperglycinuria (HP:0003108)1.94228846
78Severe combined immunodeficiency (HP:0004430)1.94213733
79Attenuation of retinal blood vessels (HP:0007843)1.93740011
80Asplenia (HP:0001746)1.93496959
81Respiratory failure (HP:0002878)1.93382568
82Cerebral palsy (HP:0100021)1.92859454
83Type 2 muscle fiber atrophy (HP:0003554)1.92323477
84Chronic diarrhea (HP:0002028)1.91966413
85Increased corneal curvature (HP:0100692)1.91026011
86Keratoconus (HP:0000563)1.91026011
87Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90512159
88Sclerocornea (HP:0000647)1.90295656
89Tubular atrophy (HP:0000092)1.89294330
90Delayed CNS myelination (HP:0002188)1.87680146
91Thyroiditis (HP:0100646)1.86761921
92Tongue fasciculations (HP:0001308)1.86396557
93Exercise intolerance (HP:0003546)1.85089260
94Abnormality of the pons (HP:0007361)1.85004660
95Pancytopenia (HP:0001876)1.82398835
96Decreased circulating renin level (HP:0003351)1.82231313
97Congenital hepatic fibrosis (HP:0002612)1.76980740
98Leukodystrophy (HP:0002415)1.76361369
99Hypoalbuminemia (HP:0003073)1.75709962
100Abnormal albumin level (HP:0012116)1.75709962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.58095081
2MAP4K23.50720439
3TXK3.43556097
4TLK13.04720455
5NUAK12.96313517
6BCKDK2.53245588
7ADRBK22.47999552
8TAOK32.36741940
9MST42.31449566
10GRK12.21556794
11FRK2.19074514
12CDK192.17718180
13ZAK2.03891949
14TIE11.84827906
15BMPR1B1.82780788
16VRK11.69093128
17STK161.68997622
18TAF11.57284403
19TRIM281.55603667
20MAP3K121.53978427
21EIF2AK31.53568573
22TSSK61.52056659
23OXSR11.51156221
24ACVR1B1.50162437
25WNK41.47514329
26PASK1.47115141
27DYRK21.36281503
28PINK11.33724924
29TGFBR11.29960339
30MAP4K11.26249261
31IKBKB1.25548811
32TNIK1.22298551
33FES1.17942370
34TEC1.14403262
35STK391.13637899
36NME11.10949651
37WNK31.03500757
38ITK1.03138500
39PHKG20.98255714
40PHKG10.98255714
41BUB10.98040668
42DAPK10.95480198
43KDR0.94117259
44EIF2AK20.92141036
45BMPR20.89753135
46KIT0.88850623
47PLK30.85661595
48ADRBK10.84374300
49MKNK10.80722543
50MAP2K60.80309180
51MYLK0.78419650
52CSNK1G30.78079073
53INSRR0.76415168
54CSNK1G20.75794509
55ERBB30.74532678
56MAPKAPK30.74162282
57CDK80.72439766
58TESK20.70524268
59FLT30.68155072
60SRPK10.68118149
61IKBKE0.68115431
62PRKCQ0.67878447
63RPS6KA50.67020645
64NEK10.66362060
65MAP3K140.65718293
66CSNK1G10.62796648
67SYK0.60902072
68GRK50.60821695
69MUSK0.60502118
70GRK60.58611064
71BTK0.56597470
72MKNK20.55584965
73PRKCE0.55083337
74PDK20.54559536
75LIMK10.53367228
76LCK0.49862849
77NME20.48078197
78CSNK1A1L0.47943339
79EIF2AK10.47674336
80MAPKAPK50.47020657
81PRKCG0.46846837
82LYN0.45714461
83DAPK30.45688713
84IRAK10.45679048
85CSF1R0.42846306
86IGF1R0.38435955
87ILK0.38000455
88MAP2K20.37731563
89CSNK1A10.37659531
90CSNK2A20.36727130
91CHUK0.35758216
92EPHA30.35742743
93GRK70.35450702
94CSNK2A10.34790271
95NLK0.33129033
96PRKCA0.32989954
97MATK0.32472284
98MAP3K40.31767829
99ALK0.31766749
100EPHB20.31337921

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.74855044
2Proteasome_Homo sapiens_hsa030503.38651213
3Ribosome_Homo sapiens_hsa030103.30194937
4Allograft rejection_Homo sapiens_hsa053303.21845188
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.13594106
6Autoimmune thyroid disease_Homo sapiens_hsa053203.02756670
7Oxidative phosphorylation_Homo sapiens_hsa001902.82683032
8Graft-versus-host disease_Homo sapiens_hsa053322.80409235
9Type I diabetes mellitus_Homo sapiens_hsa049402.65834579
10Parkinsons disease_Homo sapiens_hsa050122.29448445
11Protein export_Homo sapiens_hsa030602.27166376
12RNA polymerase_Homo sapiens_hsa030202.01091679
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94418987
14Antigen processing and presentation_Homo sapiens_hsa046121.77806462
15Primary immunodeficiency_Homo sapiens_hsa053401.76708929
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64792645
17One carbon pool by folate_Homo sapiens_hsa006701.63350321
18Linoleic acid metabolism_Homo sapiens_hsa005911.59720715
19Sulfur metabolism_Homo sapiens_hsa009201.54837775
20Caffeine metabolism_Homo sapiens_hsa002321.48219952
21Phototransduction_Homo sapiens_hsa047441.46224363
22Rheumatoid arthritis_Homo sapiens_hsa053231.43677319
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.41729158
24Huntingtons disease_Homo sapiens_hsa050161.41033395
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39542436
26Propanoate metabolism_Homo sapiens_hsa006401.33409064
27Alzheimers disease_Homo sapiens_hsa050101.33113707
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30797421
29RNA degradation_Homo sapiens_hsa030181.27577957
30Fat digestion and absorption_Homo sapiens_hsa049751.24838370
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.21342796
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15552226
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13378295
34Homologous recombination_Homo sapiens_hsa034401.12588548
35Tryptophan metabolism_Homo sapiens_hsa003801.10058626
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10053457
37Arachidonic acid metabolism_Homo sapiens_hsa005901.07757718
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06158790
39Pyrimidine metabolism_Homo sapiens_hsa002401.05207471
40Chemical carcinogenesis_Homo sapiens_hsa052041.03006318
41Peroxisome_Homo sapiens_hsa041460.99497309
42Cardiac muscle contraction_Homo sapiens_hsa042600.99330226
43Hematopoietic cell lineage_Homo sapiens_hsa046400.95757347
44Vitamin digestion and absorption_Homo sapiens_hsa049770.94298596
45Viral myocarditis_Homo sapiens_hsa054160.93413305
46Nitrogen metabolism_Homo sapiens_hsa009100.93342722
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90371896
48Basal transcription factors_Homo sapiens_hsa030220.89244344
49Purine metabolism_Homo sapiens_hsa002300.87385454
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86041578
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.84276190
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84167019
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81521766
54Glutathione metabolism_Homo sapiens_hsa004800.81274020
55Non-homologous end-joining_Homo sapiens_hsa034500.81141543
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79996252
57Retinol metabolism_Homo sapiens_hsa008300.77442365
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77151396
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76167621
60Fanconi anemia pathway_Homo sapiens_hsa034600.75988744
61Butanoate metabolism_Homo sapiens_hsa006500.74981256
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.73608651
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.73557049
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72492105
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71993292
66Sulfur relay system_Homo sapiens_hsa041220.71167013
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70478102
68Staphylococcus aureus infection_Homo sapiens_hsa051500.69192729
69Regulation of autophagy_Homo sapiens_hsa041400.68864276
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68668530
71Mismatch repair_Homo sapiens_hsa034300.67875675
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67116618
73RNA transport_Homo sapiens_hsa030130.66877000
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64995875
75Ether lipid metabolism_Homo sapiens_hsa005650.61643701
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.58552792
77Selenocompound metabolism_Homo sapiens_hsa004500.58094058
78Metabolic pathways_Homo sapiens_hsa011000.56882197
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56665133
80Collecting duct acid secretion_Homo sapiens_hsa049660.56146580
81Base excision repair_Homo sapiens_hsa034100.52839602
82Spliceosome_Homo sapiens_hsa030400.52094773
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.48037716
84Fatty acid elongation_Homo sapiens_hsa000620.47006285
85Glycerolipid metabolism_Homo sapiens_hsa005610.43747144
86Nucleotide excision repair_Homo sapiens_hsa034200.42745222
87Mineral absorption_Homo sapiens_hsa049780.42432131
88Systemic lupus erythematosus_Homo sapiens_hsa053220.41932366
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.40008813
90Pyruvate metabolism_Homo sapiens_hsa006200.38800695
91Leishmaniasis_Homo sapiens_hsa051400.37658163
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35591000
93Olfactory transduction_Homo sapiens_hsa047400.35548114
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34021888
95Renin-angiotensin system_Homo sapiens_hsa046140.33811819
96Salivary secretion_Homo sapiens_hsa049700.31198816
97Herpes simplex infection_Homo sapiens_hsa051680.30558644
98Epstein-Barr virus infection_Homo sapiens_hsa051690.29468786
99Starch and sucrose metabolism_Homo sapiens_hsa005000.24447811
100DNA replication_Homo sapiens_hsa030300.23718630

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