ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.72713185
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.61921550
3	ATP synthesis coupled proton transport (GO:0015986)	4.61921550
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.51675323
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.03013040
6	ribosomal small subunit assembly (GO:0000028)	3.95355478
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.85125132
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.85125132
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.83937623
10	protein neddylation (GO:0045116)	3.65767799
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.55429814
12	platelet dense granule organization (GO:0060155)	3.54726736
13	proteasome assembly (GO:0043248)	3.53169235
14	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.42478628
15	cullin deneddylation (GO:0010388)	3.38150492
16	protein complex biogenesis (GO:0070271)	3.36838854
17	protein deneddylation (GO:0000338)	3.36063964
18	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.34233144
19	NADH dehydrogenase complex assembly (GO:0010257)	3.34233144
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.34233144
21	cytidine metabolic process (GO:0046087)	3.34130426
22	cytidine catabolic process (GO:0006216)	3.34130426
23	cytidine deamination (GO:0009972)	3.34130426
24	termination of RNA polymerase III transcription (GO:0006386)	3.30916512
25	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.30916512
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29726607
27	fucose catabolic process (GO:0019317)	3.28144275
28	L-fucose metabolic process (GO:0042354)	3.28144275
29	L-fucose catabolic process (GO:0042355)	3.28144275
30	electron transport chain (GO:0022900)	3.25318616
31	respiratory electron transport chain (GO:0022904)	3.25013522
32	positive regulation of prostaglandin secretion (GO:0032308)	3.18972109
33	regulation of cellular amino acid metabolic process (GO:0006521)	3.18016633
34	respiratory chain complex IV assembly (GO:0008535)	3.17383579
35	preassembly of GPI anchor in ER membrane (GO:0016254)	3.12439627
36	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10225340
37	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.07139190
38	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.04716428
39	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.00887919
40	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.00887919
41	isotype switching (GO:0045190)	3.00887919
42	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.99332339
43	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.99332339
44	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.99332339
45	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.99112247
46	ribosomal large subunit biogenesis (GO:0042273)	2.97988700
47	mannosylation (GO:0097502)	2.96472041
48	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.93469499
49	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.93469499
50	chaperone-mediated protein transport (GO:0072321)	2.92196915
51	behavioral response to nicotine (GO:0035095)	2.90180611
52	rRNA modification (GO:0000154)	2.90040101
53	pseudouridine synthesis (GO:0001522)	2.87011528
54	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.86991998
55	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.86991998
56	regulation of mitotic spindle checkpoint (GO:1903504)	2.85563243
57	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.85563243
58	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.84589689
59	peptidyl-histidine modification (GO:0018202)	2.82439110
60	cytochrome complex assembly (GO:0017004)	2.81906687
61	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.81490997
62	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.81261333
63	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.79721998
64	cellular response to interleukin-15 (GO:0071350)	2.79326417
65	cotranslational protein targeting to membrane (GO:0006613)	2.76602787
66	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.75959405
67	protein targeting to ER (GO:0045047)	2.75325395
68	adenosine metabolic process (GO:0046085)	2.75115866
69	GPI anchor metabolic process (GO:0006505)	2.74355759
70	negative regulation of telomere maintenance (GO:0032205)	2.73564601
71	viral transcription (GO:0019083)	2.71675851
72	S-adenosylmethionine metabolic process (GO:0046500)	2.70960929
73	translation (GO:0006412)	2.69102739
74	positive regulation of defense response to virus by host (GO:0002230)	2.68963790
75	tRNA processing (GO:0008033)	2.68506822
76	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.68469410
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.68015742
78	piRNA metabolic process (GO:0034587)	2.67866854
79	hydrogen ion transmembrane transport (GO:1902600)	2.66769308
80	proton transport (GO:0015992)	2.66579387
81	GPI anchor biosynthetic process (GO:0006506)	2.66413191
82	translational termination (GO:0006415)	2.66412842
83	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.65785030
84	translational elongation (GO:0006414)	2.65618607
85	GTP biosynthetic process (GO:0006183)	2.64911789
86	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.63870363
87	ATP biosynthetic process (GO:0006754)	2.63541492
88	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.62656994
89	negative regulation of ligase activity (GO:0051352)	2.62656994
90	hydrogen transport (GO:0006818)	2.61676698
91	protein localization to endoplasmic reticulum (GO:0070972)	2.61626086
92	maturation of SSU-rRNA (GO:0030490)	2.61465084
93	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.60983149
94	protein-cofactor linkage (GO:0018065)	2.60402118
95	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.58967247
96	maturation of 5.8S rRNA (GO:0000460)	2.58906281
97	ubiquinone biosynthetic process (GO:0006744)	2.58728587
98	indolalkylamine metabolic process (GO:0006586)	2.55330386
99	signal peptide processing (GO:0006465)	2.54049526
100	regulation of immunoglobulin secretion (GO:0051023)	2.52330536

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.13682689
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.05542915
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.51127486
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.14237565
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04037341
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89193738
7	VDR_23849224_ChIP-Seq_CD4+_Human	2.79157247
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.70081405
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.69291391
10	VDR_22108803_ChIP-Seq_LS180_Human	2.66706428
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.65381611
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.59777923
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46904454
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46177477
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.43940532
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42029238
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35155866
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.28656200
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.24573336
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.04835433
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.99284170
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.96454813
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96193270
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.94112357
25	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.91364446
26	EWS_26573619_Chip-Seq_HEK293_Human	1.82034642
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.79873508
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.74455041
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71809318
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64084322
31	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.63854543
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.61504857
33	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.60130792
34	FUS_26573619_Chip-Seq_HEK293_Human	1.57187065
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55244235
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49868917
37	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.49443178
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48474914
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47676859
40	GATA3_26560356_Chip-Seq_TH2_Human	1.44997179
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.43775630
42	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.43556773
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.42427553
44	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.40440225
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37731381
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37731381
47	TAF15_26573619_Chip-Seq_HEK293_Human	1.37704484
48	AR_20517297_ChIP-Seq_VCAP_Human	1.35916831
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.34514896
50	P300_19829295_ChIP-Seq_ESCs_Human	1.32304514
51	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31760755
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.28133122
53	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.25733647
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.25479338
55	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24791290
56	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24771553
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24696247
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.23465213
59	ER_23166858_ChIP-Seq_MCF-7_Human	1.22976584
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22910785
61	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.22402854
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22010451
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20421519
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20421519
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19005636
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.18027653
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17856886
68	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17109324
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.16910525
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13670344
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13362322
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12734046
73	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.11153783
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.11030864
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11030864
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10291871
77	GABP_19822575_ChIP-Seq_HepG2_Human	1.10215940
78	MYB_26560356_Chip-Seq_TH2_Human	1.08461043
79	NCOR_22424771_ChIP-Seq_293T_Human	1.08433280
80	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.08082655
81	ERG_20517297_ChIP-Seq_VCAP_Human	1.04563088
82	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00553174
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00529332
84	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00096404
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97280364
86	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97277490
87	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.96962749
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96874384
89	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.96017650
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.94345464
91	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93900723
92	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.93697673
93	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.93073861
94	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.93033176
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92761279
96	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.92578441
97	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.92455237
98	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92059884
99	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.91508615
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.91433310

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.58634175
2	MP0002102_abnormal_ear_morphology	3.04325335
3	MP0001835_abnormal_antigen_presentation	3.02361277
4	MP0006072_abnormal_retinal_apoptosis	2.96311422
5	MP0008877_abnormal_DNA_methylation	2.62911265
6	MP0002138_abnormal_hepatobiliary_system	2.29807805
7	MP0004147_increased_porphyrin_level	2.27846437
8	MP0008872_abnormal_physiological_respon	2.16689651
9	MP0003786_premature_aging	2.11686744
10	MP0000685_abnormal_immune_system	2.11347423
11	MP0005645_abnormal_hypothalamus_physiol	2.10150363
12	MP0008058_abnormal_DNA_repair	1.97818371
13	MP0008995_early_reproductive_senescence	1.95555921
14	MP0005075_abnormal_melanosome_morpholog	1.94549456
15	MP0002736_abnormal_nociception_after	1.86401474
16	MP0003195_calcinosis	1.80907368
17	MP0005253_abnormal_eye_physiology	1.80221850
18	MP0001968_abnormal_touch/_nociception	1.79632831
19	MP0002166_altered_tumor_susceptibility	1.79312537
20	MP0005084_abnormal_gallbladder_morpholo	1.77578851
21	MP0001800_abnormal_humoral_immune	1.76757183
22	MP0009785_altered_susceptibility_to	1.75689126
23	MP0008875_abnormal_xenobiotic_pharmacok	1.74919323
24	MP0005551_abnormal_eye_electrophysiolog	1.74679519
25	MP0005646_abnormal_pituitary_gland	1.72103963
26	MP0002006_tumorigenesis	1.69144906
27	MP0003806_abnormal_nucleotide_metabolis	1.66556202
28	MP0001986_abnormal_taste_sensitivity	1.63898505
29	MP0002148_abnormal_hypersensitivity_rea	1.59894224
30	MP0006292_abnormal_olfactory_placode	1.59414010
31	MP0005000_abnormal_immune_tolerance	1.59321636
32	MP0002876_abnormal_thyroid_physiology	1.56129024
33	MP0004885_abnormal_endolymph	1.53597071
34	MP0005387_immune_system_phenotype	1.46531051
35	MP0001790_abnormal_immune_system	1.46531051
36	MP0002723_abnormal_immune_serum	1.42437837
37	MP0001529_abnormal_vocalization	1.39584266
38	MP0002837_dystrophic_cardiac_calcinosis	1.38239847
39	MP0003763_abnormal_thymus_physiology	1.36607756
40	MP0009764_decreased_sensitivity_to	1.34192210
41	MP0004142_abnormal_muscle_tone	1.32676046
42	MP0003011_delayed_dark_adaptation	1.32456182
43	MP0000372_irregular_coat_pigmentation	1.31384106
44	MP0006036_abnormal_mitochondrial_physio	1.31317098
45	MP0002163_abnormal_gland_morphology	1.30818701
46	MP0001764_abnormal_homeostasis	1.30308272
47	MP0001819_abnormal_immune_cell	1.28584934
48	MP0002420_abnormal_adaptive_immunity	1.27028246
49	MP0005360_urolithiasis	1.26326935
50	MP0003724_increased_susceptibility_to	1.26153557
51	MP0002452_abnormal_antigen_presenting	1.25390848
52	MP0003718_maternal_effect	1.22974248
53	MP0009333_abnormal_splenocyte_physiolog	1.21365200
54	MP0004043_abnormal_pH_regulation	1.16824511
55	MP0009379_abnormal_foot_pigmentation	1.16296968
56	MP0004145_abnormal_muscle_electrophysio	1.12003371
57	MP0001501_abnormal_sleep_pattern	1.10868890
58	MP0002277_abnormal_respiratory_mucosa	1.10114561
59	MP0001873_stomach_inflammation	1.09750098
60	MP0001919_abnormal_reproductive_system	1.09058037
61	MP0010155_abnormal_intestine_physiology	1.09055418
62	MP0005332_abnormal_amino_acid	1.07918256
63	MP0005389_reproductive_system_phenotype	1.06660372
64	MP0005410_abnormal_fertilization	1.04101562
65	MP0006035_abnormal_mitochondrial_morpho	1.04062435
66	MP0003866_abnormal_defecation	1.03518940
67	MP0003186_abnormal_redox_activity	1.01559881
68	MP0005085_abnormal_gallbladder_physiolo	1.01215089
69	MP0002938_white_spotting	1.00750376
70	MP0002638_abnormal_pupillary_reflex	0.98885794
71	MP0001845_abnormal_inflammatory_respons	0.98445125
72	MP0003252_abnormal_bile_duct	0.98408473
73	MP0010386_abnormal_urinary_bladder	0.96880899
74	MP0005379_endocrine/exocrine_gland_phen	0.96406428
75	MP0002095_abnormal_skin_pigmentation	0.96335524
76	MP0000689_abnormal_spleen_morphology	0.92937900
77	MP0000716_abnormal_immune_system	0.90819885
78	MP0002693_abnormal_pancreas_physiology	0.90275458
79	MP0002234_abnormal_pharynx_morphology	0.88641326
80	MP0002398_abnormal_bone_marrow	0.88633644
81	MP0005025_abnormal_response_to	0.87662342
82	MP0003880_abnormal_central_pattern	0.87577142
83	MP0002272_abnormal_nervous_system	0.85581825
84	MP0005636_abnormal_mineral_homeostasis	0.82687398
85	MP0000427_abnormal_hair_cycle	0.82435166
86	MP0003436_decreased_susceptibility_to	0.81165611
87	MP0003787_abnormal_imprinting	0.81033178
88	MP0001119_abnormal_female_reproductive	0.77608852
89	MP0003646_muscle_fatigue	0.77138492
90	MP0010094_abnormal_chromosome_stability	0.74276659
91	MP0002751_abnormal_autonomic_nervous	0.74269690
92	MP0001929_abnormal_gametogenesis	0.73962458
93	MP0001905_abnormal_dopamine_level	0.73796168
94	MP0000647_abnormal_sebaceous_gland	0.73455890
95	MP0009643_abnormal_urine_homeostasis	0.72897467
96	MP0002405_respiratory_system_inflammati	0.72027794
97	MP0002722_abnormal_immune_system	0.71997475
98	MP0009697_abnormal_copulation	0.71357889
99	MP0003567_abnormal_fetal_cardiomyocyte	0.71179707
100	MP0000631_abnormal_neuroendocrine_gland	0.70408874

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.86411771
2	Mitochondrial inheritance (HP:0001427)	3.80133619
3	Increased hepatocellular lipid droplets (HP:0006565)	3.54197345
4	Increased CSF lactate (HP:0002490)	3.51171327
5	Acute encephalopathy (HP:0006846)	3.49945080
6	IgG deficiency (HP:0004315)	3.46098376
7	Lipid accumulation in hepatocytes (HP:0006561)	3.43448587
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.35238086
9	Hepatocellular necrosis (HP:0001404)	3.32739118
10	Progressive macrocephaly (HP:0004481)	3.26399673
11	Congenital stationary night blindness (HP:0007642)	3.17887781
12	Hepatic necrosis (HP:0002605)	3.16147138
13	Congenital, generalized hypertrichosis (HP:0004540)	3.15904518
14	Methylmalonic acidemia (HP:0002912)	3.12129401
15	Pancreatic cysts (HP:0001737)	3.09643965
16	Stomatitis (HP:0010280)	3.06149002
17	3-Methylglutaconic aciduria (HP:0003535)	2.99416980
18	Severe combined immunodeficiency (HP:0004430)	2.79472813
19	Renal Fanconi syndrome (HP:0001994)	2.73817512
20	Increased serum lactate (HP:0002151)	2.70720256
21	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.69675619
22	Cerebral edema (HP:0002181)	2.66640903
23	Abnormality of midbrain morphology (HP:0002418)	2.66577885
24	Molar tooth sign on MRI (HP:0002419)	2.66577885
25	Renal cortical cysts (HP:0000803)	2.66460202
26	True hermaphroditism (HP:0010459)	2.66180755
27	Abolished electroretinogram (ERG) (HP:0000550)	2.64785865
28	Abnormality of the renal cortex (HP:0011035)	2.64174308
29	Type II lissencephaly (HP:0007260)	2.56773708
30	Pancreatic fibrosis (HP:0100732)	2.56378961
31	Methylmalonic aciduria (HP:0012120)	2.55181033
32	Elevated erythrocyte sedimentation rate (HP:0003565)	2.53230870
33	Nephronophthisis (HP:0000090)	2.51106319
34	Large for gestational age (HP:0001520)	2.50757396
35	Lactic acidosis (HP:0003128)	2.46396650
36	Optic disc pallor (HP:0000543)	2.46295583
37	Aplastic anemia (HP:0001915)	2.43992042
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.41858184
39	Increased intramyocellular lipid droplets (HP:0012240)	2.37585970
40	Thyroiditis (HP:0100646)	2.34862649
41	Attenuation of retinal blood vessels (HP:0007843)	2.34734240
42	Exertional dyspnea (HP:0002875)	2.32212842
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32129204
44	Abnormality of alanine metabolism (HP:0010916)	2.32129204
45	Hyperalaninemia (HP:0003348)	2.32129204
46	Abnormality of T cell number (HP:0011839)	2.31896933
47	Hypoproteinemia (HP:0003075)	2.26825202
48	Abnormality of T cells (HP:0002843)	2.24853092
49	Abnormality of urine glucose concentration (HP:0011016)	2.24224986
50	Glycosuria (HP:0003076)	2.24224986
51	Abnormality of the prostate (HP:0008775)	2.22637298
52	Medial flaring of the eyebrow (HP:0010747)	2.21243377
53	Lethargy (HP:0001254)	2.19822109
54	Ketoacidosis (HP:0001993)	2.18170697
55	T lymphocytopenia (HP:0005403)	2.17229767
56	Abnormality of the renal medulla (HP:0100957)	2.16489964
57	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.16441722
58	Hyperglycinemia (HP:0002154)	2.15170686
59	Abnormal rod and cone electroretinograms (HP:0008323)	2.15069279
60	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.14981793
61	Oral leukoplakia (HP:0002745)	2.12840296
62	Stomach cancer (HP:0012126)	2.12176739
63	Abnormal number of erythroid precursors (HP:0012131)	2.11607917
64	Hypothermia (HP:0002045)	2.11427372
65	Pancytopenia (HP:0001876)	2.11225974
66	Abnormality of T cell physiology (HP:0011840)	2.10675996
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.10622072
68	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.10622072
69	Abnormality of the pons (HP:0007361)	2.07115746
70	Abnormality of B cell number (HP:0010975)	2.06893039
71	Combined immunodeficiency (HP:0005387)	2.06776105
72	Prostate neoplasm (HP:0100787)	2.03862501
73	Increased IgM level (HP:0003496)	2.02741387
74	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.02470527
75	Abnormality of vitamin B metabolism (HP:0004340)	2.00253226
76	Abnormality of eosinophils (HP:0001879)	2.00089859
77	Increased muscle lipid content (HP:0009058)	1.98481012
78	Type I transferrin isoform profile (HP:0003642)	1.96984736
79	Ketosis (HP:0001946)	1.96921170
80	Abnormality of serum amino acid levels (HP:0003112)	1.96677184
81	Colon cancer (HP:0003003)	1.96560921
82	Generalized aminoaciduria (HP:0002909)	1.96497348
83	Pancreatic islet-cell hyperplasia (HP:0004510)	1.95527002
84	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95060292
85	Respiratory failure (HP:0002878)	1.93981065
86	Abnormality of cells of the erythroid lineage (HP:0012130)	1.93155890
87	Constricted visual fields (HP:0001133)	1.92338720
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.92015215
89	Abnormality of glycine metabolism (HP:0010895)	1.92015215
90	Hyperglycinuria (HP:0003108)	1.89500987
91	Dicarboxylic aciduria (HP:0003215)	1.88240319
92	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.88240319
93	Hyperinsulinemic hypoglycemia (HP:0000825)	1.85808472
94	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.84041835
95	Hypoplasia of the pons (HP:0012110)	1.83317355
96	Reticulocytopenia (HP:0001896)	1.82680412
97	Abnormal biliary tract physiology (HP:0012439)	1.81359633
98	Bile duct proliferation (HP:0001408)	1.81359633
99	Neutropenia (HP:0001875)	1.80545033
100	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.80281993

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.48933340
2	TXK	3.39379838
3	ZAK	3.34654770
4	VRK2	2.90431045
5	MAP4K2	2.83967542
6	NUAK1	2.78720472
7	TAOK3	2.67255578
8	ADRBK2	2.27941589
9	GRK1	2.19185152
10	MST4	2.12712767
11	MAP3K12	2.05142464
12	STK16	1.96045004
13	PASK	1.88188259
14	EIF2AK3	1.86531932
15	CDK19	1.84828238
16	VRK1	1.80366502
17	FRK	1.76880948
18	BCKDK	1.64188332
19	MAP4K1	1.62734994
20	PINK1	1.56422738
21	TAF1	1.51808504
22	BMPR1B	1.50884628
23	WNK3	1.49120837
24	KDR	1.47957065
25	IKBKB	1.26188211
26	SRPK1	1.25767170
27	TESK2	1.19410629
28	TEC	1.18012478
29	TRIM28	1.17637576
30	KIT	1.15632529
31	BUB1	1.15621071
32	TIE1	1.15490986
33	WNK4	1.15405407
34	GRK6	1.13613268
35	MAP3K4	1.07437827
36	TSSK6	1.06455087
37	FES	1.04624044
38	ACVR1B	1.04194424
39	ITK	1.02579363
40	EIF2AK2	0.95974271
41	OXSR1	0.93312308
42	MAPKAPK3	0.92066314
43	INSRR	0.91912587
44	CSNK1G3	0.91637169
45	DYRK2	0.91503343
46	NME1	0.90931110
47	BMPR2	0.89156405
48	CSNK1G2	0.88773221
49	PLK4	0.87637552
50	IKBKE	0.87599381
51	PLK3	0.85239403
52	TGFBR1	0.85109365
53	DAPK1	0.84429486
54	CSNK1G1	0.84285766
55	SYK	0.83703108
56	ERBB3	0.82805997
57	RPS6KA4	0.80796718
58	BCR	0.80459624
59	CAMKK2	0.78904685
60	PLK2	0.78495172
61	MYLK	0.78004706
62	NEK1	0.72446526
63	CDK8	0.71000181
64	CSNK1A1L	0.70960806
65	MKNK1	0.70363654
66	RPS6KA5	0.68586985
67	STK39	0.68160226
68	ADRBK1	0.67295002
69	FLT3	0.67088673
70	MAP2K7	0.65120666
71	CSF1R	0.63981297
72	GRK7	0.62223234
73	MAP3K14	0.61592717
74	MAP2K2	0.58515372
75	PRKCQ	0.57866632
76	LCK	0.57822266
77	LYN	0.55235600
78	PIK3CG	0.54266865
79	BRSK2	0.53364828
80	PRKCE	0.53157144
81	PHKG1	0.52654281
82	PHKG2	0.52654281
83	SCYL2	0.51775570
84	MAP2K6	0.50527965
85	ATR	0.50192810
86	MUSK	0.50112792
87	MKNK2	0.47308484
88	IGF1R	0.46854868
89	TRPM7	0.45528897
90	BTK	0.45209291
91	MAPK13	0.44787921
92	PDK2	0.43874151
93	CDC7	0.40684980
94	LIMK1	0.38644957
95	GRK5	0.38477694
96	CSNK2A1	0.37883243
97	CSNK2A2	0.36190181
98	CSNK1A1	0.35098351
99	TBK1	0.32892119
100	DYRK3	0.32631424

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.84941688
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17954323
3	Ribosome_Homo sapiens_hsa03010	2.90067990
4	Protein export_Homo sapiens_hsa03060	2.86671840
5	Asthma_Homo sapiens_hsa05310	2.78934631
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.58036149
7	RNA polymerase_Homo sapiens_hsa03020	2.54606366
8	Parkinsons disease_Homo sapiens_hsa05012	2.54439114
9	Allograft rejection_Homo sapiens_hsa05330	2.48120357
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.40845956
11	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.32828867
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.25759968
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.17853643
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97864237
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.79974081
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.63068786
17	One carbon pool by folate_Homo sapiens_hsa00670	1.59904937
18	RNA degradation_Homo sapiens_hsa03018	1.57985044
19	Homologous recombination_Homo sapiens_hsa03440	1.56016987
20	Alzheimers disease_Homo sapiens_hsa05010	1.55864222
21	Huntingtons disease_Homo sapiens_hsa05016	1.54774004
22	Phototransduction_Homo sapiens_hsa04744	1.54439615
23	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.54065619
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.48799962
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43084246
26	Propanoate metabolism_Homo sapiens_hsa00640	1.40110905
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39822085
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.37662415
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.36118885
30	Basal transcription factors_Homo sapiens_hsa03022	1.34045359
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30407355
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29519902
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29442568
34	Sulfur metabolism_Homo sapiens_hsa00920	1.23213386
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.19235572
36	Nitrogen metabolism_Homo sapiens_hsa00910	1.19175731
37	Mismatch repair_Homo sapiens_hsa03430	1.16975762
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.15202205
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.11396753
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.10064979
41	Purine metabolism_Homo sapiens_hsa00230	1.05451882
42	Caffeine metabolism_Homo sapiens_hsa00232	1.04712820
43	Butanoate metabolism_Homo sapiens_hsa00650	1.03130140
44	RNA transport_Homo sapiens_hsa03013	1.02359637
45	Spliceosome_Homo sapiens_hsa03040	1.01510715
46	Nucleotide excision repair_Homo sapiens_hsa03420	1.01376930
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00450265
48	Peroxisome_Homo sapiens_hsa04146	0.99461575
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.98930043
50	Regulation of autophagy_Homo sapiens_hsa04140	0.97888423
51	Cardiac muscle contraction_Homo sapiens_hsa04260	0.95227654
52	Base excision repair_Homo sapiens_hsa03410	0.92474316
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.87656985
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84616859
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84449113
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84313686
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.83371763
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83366871
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.81026318
60	DNA replication_Homo sapiens_hsa03030	0.79702509
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78375866
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71743124
63	Collecting duct acid secretion_Homo sapiens_hsa04966	0.71141797
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70244659
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.69651730
66	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.67569003
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64197895
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63173154
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62905712
70	Glutathione metabolism_Homo sapiens_hsa00480	0.62390023
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.62319938
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62237440
73	Metabolic pathways_Homo sapiens_hsa01100	0.62128483
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60826933
75	Viral myocarditis_Homo sapiens_hsa05416	0.60779792
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.60027386
77	Fatty acid elongation_Homo sapiens_hsa00062	0.59895987
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.59554312
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.57586342
80	Retinol metabolism_Homo sapiens_hsa00830	0.54891371
81	Fat digestion and absorption_Homo sapiens_hsa04975	0.52480257
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51926628
83	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.49880871
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49189447
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47576336
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46424312
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44232315
88	Olfactory transduction_Homo sapiens_hsa04740	0.43238032
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41864645
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.41420640
91	Taste transduction_Homo sapiens_hsa04742	0.40613929
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40221748
93	Herpes simplex infection_Homo sapiens_hsa05168	0.38075460
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.37814689
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35017070
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.31324432
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30506962
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.29053175
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.26222691
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25229018

EEF1A1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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