EEF1A1P41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.24783649
2translational termination (GO:0006415)7.00783772
3ribosomal small subunit biogenesis (GO:0042274)6.68153414
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.31168846
5behavioral response to nicotine (GO:0035095)5.91177557
6translational elongation (GO:0006414)5.79124603
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.71574141
8cotranslational protein targeting to membrane (GO:0006613)5.68761450
9protein targeting to ER (GO:0045047)5.65334865
10ribosomal small subunit assembly (GO:0000028)5.64888599
11maturation of SSU-rRNA (GO:0030490)5.43001731
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.41823434
13cellular protein complex disassembly (GO:0043624)5.41760235
14pattern specification involved in kidney development (GO:0061004)5.41047538
15viral life cycle (GO:0019058)5.35067413
16protein localization to endoplasmic reticulum (GO:0070972)5.27976923
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.10888814
18protein complex disassembly (GO:0043241)4.71470998
19pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.50052965
20macromolecular complex disassembly (GO:0032984)4.47555383
21motile cilium assembly (GO:0044458)4.30237344
22translational initiation (GO:0006413)4.11017695
23epithelial cilium movement (GO:0003351)3.98720938
24body morphogenesis (GO:0010171)3.97495489
25pyrimidine nucleotide catabolic process (GO:0006244)3.95435798
26pyrimidine nucleobase catabolic process (GO:0006208)3.88192134
27protein targeting to membrane (GO:0006612)3.84680463
28substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.67313246
29substrate-independent telencephalic tangential migration (GO:0021826)3.67313246
30synaptic transmission, cholinergic (GO:0007271)3.62759330
31spinal cord association neuron differentiation (GO:0021527)3.61437557
32regulation of nuclear cell cycle DNA replication (GO:0033262)3.60852388
33intraciliary transport (GO:0042073)3.58838292
34base-excision repair, AP site formation (GO:0006285)3.57045980
35nonmotile primary cilium assembly (GO:0035058)3.54448287
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47945995
37embryonic body morphogenesis (GO:0010172)3.47653192
38somite development (GO:0061053)3.47035588
39protein neddylation (GO:0045116)3.41632803
40chaperone-mediated protein transport (GO:0072321)3.38647935
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.37534643
42establishment of mitochondrion localization (GO:0051654)3.35585157
43segment specification (GO:0007379)3.29321491
44protein polyglutamylation (GO:0018095)3.28861499
45axonemal dynein complex assembly (GO:0070286)3.27718792
46regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.23057645
47water-soluble vitamin biosynthetic process (GO:0042364)3.21774253
48response to redox state (GO:0051775)3.21179634
49protein localization to cilium (GO:0061512)3.21120976
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20855761
51mitochondrion transport along microtubule (GO:0047497)3.20855761
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.19974706
53NADH dehydrogenase complex assembly (GO:0010257)3.19974706
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19974706
55mRNA catabolic process (GO:0006402)3.18599366
56DNA replication checkpoint (GO:0000076)3.17501740
57cilium movement (GO:0003341)3.15022285
58ribosomal large subunit biogenesis (GO:0042273)3.14013790
59cell proliferation in forebrain (GO:0021846)3.10316088
60dendritic spine morphogenesis (GO:0060997)3.07779523
61tongue development (GO:0043586)3.07493879
62regulation of glycogen (starch) synthase activity (GO:2000465)3.07330957
63head development (GO:0060322)3.05420088
64auditory receptor cell differentiation (GO:0042491)3.03459590
65nucleobase catabolic process (GO:0046113)3.01613950
66central nervous system myelination (GO:0022010)2.99882668
67axon ensheathment in central nervous system (GO:0032291)2.99882668
68transmission of nerve impulse (GO:0019226)2.95516915
69pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93977729
70translation (GO:0006412)2.91821887
71axoneme assembly (GO:0035082)2.91524300
72behavioral response to ethanol (GO:0048149)2.89438157
73telencephalon development (GO:0021537)2.88421421
74cardiovascular system development (GO:0072358)2.87890427
75protein complex biogenesis (GO:0070271)2.86949734
76cerebral cortex radially oriented cell migration (GO:0021799)2.84404126
77RNA catabolic process (GO:0006401)2.82084510
78axonal fasciculation (GO:0007413)2.80455565
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.76460962
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76411755
81smoothened signaling pathway (GO:0007224)2.76382339
82ATP synthesis coupled proton transport (GO:0015986)2.75550509
83energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75550509
84Sertoli cell development (GO:0060009)2.75280798
85glycerophospholipid catabolic process (GO:0046475)2.74144545
86hypothalamus development (GO:0021854)2.73484108
87appendage development (GO:0048736)2.72983618
88limb development (GO:0060173)2.72983618
89intra-S DNA damage checkpoint (GO:0031573)2.72478528
90negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65899370
91microtubule severing (GO:0051013)2.61448411
92mitochondrial respiratory chain complex assembly (GO:0033108)2.60964582
93regulation of action potential (GO:0098900)2.60614559
94sex differentiation (GO:0007548)2.60370555
95regulation of microtubule-based movement (GO:0060632)2.58191317
96startle response (GO:0001964)2.58050627
97establishment of protein localization to membrane (GO:0090150)2.57853489
98lens fiber cell development (GO:0070307)2.57728933
99positive regulation of neurological system process (GO:0031646)2.56730789
100cellular component biogenesis (GO:0044085)2.54109974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.42551564
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.62359736
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.38006932
4ZNF274_21170338_ChIP-Seq_K562_Hela2.39289380
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.37865923
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.22677627
7CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.14732639
8REST_21632747_ChIP-Seq_MESCs_Mouse2.09085402
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06300573
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.01169432
11SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99678881
12BMI1_23680149_ChIP-Seq_NPCS_Mouse1.88985383
13REST_18959480_ChIP-ChIP_MESCs_Mouse1.88360345
14GATA1_26923725_Chip-Seq_HPCs_Mouse1.86852389
15RNF2_27304074_Chip-Seq_ESCs_Mouse1.83118286
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82979197
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78741979
18EED_16625203_ChIP-ChIP_MESCs_Mouse1.75946142
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68482118
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65771656
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64368909
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64368909
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63284297
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58553805
25RNF2_27304074_Chip-Seq_NSC_Mouse1.58212210
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.57247929
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54656206
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53295058
29IRF1_19129219_ChIP-ChIP_H3396_Human1.52634981
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51909724
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49203389
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48792698
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45524687
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.45058789
35SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.44866386
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44539237
37ERA_21632823_ChIP-Seq_H3396_Human1.39896462
38ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38392373
39CTCF_27219007_Chip-Seq_Bcells_Human1.38083216
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37784136
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.36268442
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35132297
43SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.34584361
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33443063
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.30811698
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28830781
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25392359
48XRN2_22483619_ChIP-Seq_HELA_Human1.24197109
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20515305
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.20482162
51MYC_18940864_ChIP-ChIP_HL60_Human1.19302459
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16664372
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16314315
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15167166
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14940585
56TTF2_22483619_ChIP-Seq_HELA_Human1.14649312
57DROSHA_22980978_ChIP-Seq_HELA_Human1.13089940
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12353097
59TAF2_19829295_ChIP-Seq_ESCs_Human1.10463758
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10260970
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10188622
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09444260
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08646358
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07594961
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.07493716
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.07300935
67WDR5_24793694_ChIP-Seq_LNCAP_Human1.07118919
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07102153
69FUS_26573619_Chip-Seq_HEK293_Human1.06897583
70TP53_22573176_ChIP-Seq_HFKS_Human1.06817772
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06699412
72E2F1_17053090_ChIP-ChIP_MCF-7_Human1.06652408
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05221031
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.03800729
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03443140
76OCT4_19829295_ChIP-Seq_ESCs_Human1.00798538
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.00120123
78SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98879014
79MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98664231
80CTCF_20526341_ChIP-Seq_ESCs_Human0.96950636
81CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96632759
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96000299
83NANOG_20526341_ChIP-Seq_ESCs_Human0.95310623
84STAT1_20625510_ChIP-Seq_HELA_Human0.94660310
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93247026
86P68_20966046_ChIP-Seq_HELA_Human0.93087246
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.92871028
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91439107
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.91326780
90NCOR_22424771_ChIP-Seq_293T_Human0.90938311
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89815569
92NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88366968
93SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87135319
94CTCF_18555785_ChIP-Seq_MESCs_Mouse0.85560552
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85379318
96BCL6_27268052_Chip-Seq_Bcells_Human0.85303467
97BCAT_22108803_ChIP-Seq_LS180_Human0.84201804
98SA1_27219007_Chip-Seq_Bcells_Human0.84045663
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.83012956
100THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82659913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.39639367
2MP0008877_abnormal_DNA_methylation4.10714936
3MP0009379_abnormal_foot_pigmentation4.10307060
4MP0003122_maternal_imprinting3.39455636
5MP0006292_abnormal_olfactory_placode3.11695914
6MP0002653_abnormal_ependyma_morphology2.93218419
7MP0002163_abnormal_gland_morphology2.83805993
8MP0003121_genomic_imprinting2.72691728
9MP0003123_paternal_imprinting2.67942183
10MP0006276_abnormal_autonomic_nervous2.53903709
11MP0000778_abnormal_nervous_system2.49451658
12MP0004142_abnormal_muscle_tone2.36267460
13MP0003646_muscle_fatigue2.19524602
14MP0000566_synostosis2.03157110
15MP0003880_abnormal_central_pattern1.97376963
16MP0002102_abnormal_ear_morphology1.93484543
17MP0003136_yellow_coat_color1.91611091
18MP0002638_abnormal_pupillary_reflex1.88226571
19MP0004145_abnormal_muscle_electrophysio1.85857600
20MP0006072_abnormal_retinal_apoptosis1.79173181
21MP0004885_abnormal_endolymph1.70299621
22MP0005394_taste/olfaction_phenotype1.69421671
23MP0005499_abnormal_olfactory_system1.69421671
24MP0005423_abnormal_somatic_nervous1.68943868
25MP0008789_abnormal_olfactory_epithelium1.61431943
26MP0005377_hearing/vestibular/ear_phenot1.61250970
27MP0003878_abnormal_ear_physiology1.61250970
28MP0002557_abnormal_social/conspecific_i1.61227020
29MP0009046_muscle_twitch1.60980079
30MP0005551_abnormal_eye_electrophysiolog1.54525980
31MP0002063_abnormal_learning/memory/cond1.50482565
32MP0000049_abnormal_middle_ear1.49825582
33MP0002272_abnormal_nervous_system1.48136188
34MP0001293_anophthalmia1.45026741
35MP0003011_delayed_dark_adaptation1.43150251
36MP0004859_abnormal_synaptic_plasticity1.42696745
37MP0001968_abnormal_touch/_nociception1.42237247
38MP0001970_abnormal_pain_threshold1.40933613
39MP0000631_abnormal_neuroendocrine_gland1.40833090
40MP0000955_abnormal_spinal_cord1.39830752
41MP0002184_abnormal_innervation1.38774029
42MP0003635_abnormal_synaptic_transmissio1.37968944
43MP0001440_abnormal_grooming_behavior1.36791849
44MP0002572_abnormal_emotion/affect_behav1.36175017
45MP0002733_abnormal_thermal_nociception1.35192125
46MP0005195_abnormal_posterior_eye1.27912120
47MP0004858_abnormal_nervous_system1.27108229
48MP0001485_abnormal_pinna_reflex1.25783881
49MP0003567_abnormal_fetal_cardiomyocyte1.25104498
50MP0004742_abnormal_vestibular_system1.23511604
51MP0001529_abnormal_vocalization1.22796748
52MP0002735_abnormal_chemical_nociception1.19782572
53MP0009745_abnormal_behavioral_response1.19588266
54MP0002752_abnormal_somatic_nervous1.19138000
55MP0002734_abnormal_mechanical_nocicepti1.19018034
56MP0005379_endocrine/exocrine_gland_phen1.16732629
57MP0001486_abnormal_startle_reflex1.15453421
58MP0002938_white_spotting1.14291537
59MP0003938_abnormal_ear_development1.13933448
60MP0001905_abnormal_dopamine_level1.12790599
61MP0002882_abnormal_neuron_morphology1.12606957
62MP0005646_abnormal_pituitary_gland1.10845399
63MP0010030_abnormal_orbit_morphology1.06603306
64MP0003879_abnormal_hair_cell1.05554058
65MP0004133_heterotaxia1.04699115
66MP0002064_seizures1.02749299
67MP0000026_abnormal_inner_ear1.00882793
68MP0005253_abnormal_eye_physiology1.00427602
69MP0003890_abnormal_embryonic-extraembry1.00140144
70MP0002152_abnormal_brain_morphology0.99025264
71MP0001502_abnormal_circadian_rhythm0.98764036
72MP0002067_abnormal_sensory_capabilities0.97667422
73MP0005645_abnormal_hypothalamus_physiol0.97570823
74MP0002736_abnormal_nociception_after0.92619907
75MP0003942_abnormal_urinary_system0.92397414
76MP0005084_abnormal_gallbladder_morpholo0.91461265
77MP0001986_abnormal_taste_sensitivity0.89031003
78MP0004130_abnormal_muscle_cell0.89027808
79MP0003861_abnormal_nervous_system0.88874744
80MP0002138_abnormal_hepatobiliary_system0.86801761
81MP0004811_abnormal_neuron_physiology0.86245597
82MP0001963_abnormal_hearing_physiology0.86160919
83MP0005386_behavior/neurological_phenoty0.85874952
84MP0004924_abnormal_behavior0.85874952
85MP0003937_abnormal_limbs/digits/tail_de0.85414558
86MP0001919_abnormal_reproductive_system0.83858174
87MP0002822_catalepsy0.83595306
88MP0008872_abnormal_physiological_respon0.81473807
89MP0008875_abnormal_xenobiotic_pharmacok0.79928777
90MP0001286_abnormal_eye_development0.77149750
91MP0003283_abnormal_digestive_organ0.76400892
92MP0000427_abnormal_hair_cycle0.74906174
93MP0009053_abnormal_anal_canal0.74600602
94MP0005391_vision/eye_phenotype0.73938873
95MP0005389_reproductive_system_phenotype0.72541714
96MP0000372_irregular_coat_pigmentation0.72327158
97MP0001188_hyperpigmentation0.71160544
98MP0002066_abnormal_motor_capabilities/c0.70845866
99MP0003183_abnormal_peptide_metabolism0.70128852
100MP0002249_abnormal_larynx_morphology0.67958153

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.30068123
2Septo-optic dysplasia (HP:0100842)4.11528644
3Abnormality of cells of the erythroid lineage (HP:0012130)3.79332159
4Abnormality of midbrain morphology (HP:0002418)3.76257787
5Molar tooth sign on MRI (HP:0002419)3.76257787
6Acute necrotizing encephalopathy (HP:0006965)3.51202985
7Pancreatic fibrosis (HP:0100732)3.37981914
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.37702021
9Absent/shortened dynein arms (HP:0200106)3.37702021
10Abnormal respiratory epithelium morphology (HP:0012253)3.32215189
11Abnormal respiratory motile cilium morphology (HP:0005938)3.32215189
12Macrocytic anemia (HP:0001972)3.31288585
13Abnormality of the corticospinal tract (HP:0002492)3.29109203
14Medial flaring of the eyebrow (HP:0010747)3.13416555
15Polyphagia (HP:0002591)3.12585956
16Nephronophthisis (HP:0000090)3.01961971
17Papilledema (HP:0001085)2.98352811
18Acute encephalopathy (HP:0006846)2.93011732
19Abnormal mitochondria in muscle tissue (HP:0008316)2.92394703
20Absent septum pellucidum (HP:0001331)2.83696948
21Oligodactyly (hands) (HP:0001180)2.83600165
22Abnormality of the labia minora (HP:0012880)2.82167417
23Gait imbalance (HP:0002141)2.77660496
24Stenosis of the external auditory canal (HP:0000402)2.75998497
25Rib fusion (HP:0000902)2.70921735
26Lissencephaly (HP:0001339)2.65263127
27Pallor (HP:0000980)2.64439170
28Pancreatic cysts (HP:0001737)2.64188879
29Cystic liver disease (HP:0006706)2.64038935
30Pachygyria (HP:0001302)2.63456048
31Progressive macrocephaly (HP:0004481)2.63238850
32Agitation (HP:0000713)2.60669801
33Abnormal ciliary motility (HP:0012262)2.55668372
34Supernumerary spleens (HP:0009799)2.54321845
35Type II lissencephaly (HP:0007260)2.51982671
36Colon cancer (HP:0003003)2.48908877
37Abnormal number of erythroid precursors (HP:0012131)2.42282721
38Congenital primary aphakia (HP:0007707)2.41227914
39Anencephaly (HP:0002323)2.39450799
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.37899769
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.37899769
42Abnormality of the diencephalon (HP:0010662)2.37403298
43True hermaphroditism (HP:0010459)2.36774859
44Abnormal hemoglobin (HP:0011902)2.31862335
45Hyperthyroidism (HP:0000836)2.31682136
46Poor coordination (HP:0002370)2.30352020
47Abnormal drinking behavior (HP:0030082)2.29872912
48Polydipsia (HP:0001959)2.29872912
49Pendular nystagmus (HP:0012043)2.29531368
50Abnormal hair whorl (HP:0010721)2.25506690
51Growth hormone deficiency (HP:0000824)2.24975537
52Oligodactyly (HP:0012165)2.24920609
53Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.24165324
54Abnormal respiratory motile cilium physiology (HP:0012261)2.21675107
55Congenital stationary night blindness (HP:0007642)2.21062160
56Spastic tetraplegia (HP:0002510)2.20640832
57Abnormality of the renal medulla (HP:0100957)2.19331784
58Abnormality of the lower motor neuron (HP:0002366)2.18526461
59Mitochondrial inheritance (HP:0001427)2.18374593
60Progressive cerebellar ataxia (HP:0002073)2.16254432
61Impulsivity (HP:0100710)2.16218784
62Optic nerve hypoplasia (HP:0000609)2.15046601
63Abnormal eating behavior (HP:0100738)2.14419661
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.13387342
65Nephrogenic diabetes insipidus (HP:0009806)2.13182137
66Hip dysplasia (HP:0001385)2.10053252
67Myokymia (HP:0002411)2.07694773
68Abnormality of the aortic arch (HP:0012303)2.06684229
69Asplenia (HP:0001746)2.04041464
70Abnormality of the septum pellucidum (HP:0007375)2.03874657
71Chronic hepatic failure (HP:0100626)2.02888027
72Cerebellar dysplasia (HP:0007033)2.01630375
73Cerebral edema (HP:0002181)2.00809237
74Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99417811
75Depressed nasal ridge (HP:0000457)1.99410765
76Maternal diabetes (HP:0009800)1.98863339
77Deep palmar crease (HP:0006191)1.98760529
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94128493
79Abnormal rod and cone electroretinograms (HP:0008323)1.92536453
80Sclerocornea (HP:0000647)1.91771705
81Sleep apnea (HP:0010535)1.88748469
82Specific learning disability (HP:0001328)1.88320609
83Oligomenorrhea (HP:0000876)1.87658959
84Optic disc pallor (HP:0000543)1.87161487
85Increased CSF lactate (HP:0002490)1.85963301
86Genetic anticipation (HP:0003743)1.84915457
87Postaxial foot polydactyly (HP:0001830)1.83311125
88Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83301871
893-Methylglutaconic aciduria (HP:0003535)1.79782349
90Diastasis recti (HP:0001540)1.79750893
91Postaxial hand polydactyly (HP:0001162)1.78075897
92Broad alveolar ridges (HP:0000187)1.77265463
93Tubular atrophy (HP:0000092)1.76560370
94Long foot (HP:0001833)1.75728302
95Hypoplasia of the brainstem (HP:0002365)1.75654589
96Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75654589
97Vaginal atresia (HP:0000148)1.75372984
98Morphological abnormality of the pyramidal tract (HP:0002062)1.72302352
99Broad distal phalanx of finger (HP:0009836)1.72064169
100Amyotrophic lateral sclerosis (HP:0007354)1.71320820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.52117055
2DYRK22.78214192
3PINK12.65251489
4CAMKK22.52094865
5MARK12.39900074
6CDK192.31709580
7NTRK22.29741301
8EPHB22.20730166
9CAMK1D2.13323514
10GRK12.12968418
11LRRK22.04717638
12TLK12.02968308
13BMPR1B1.99906641
14CDC71.94573631
15NUAK11.89637408
16CAMK1G1.85031983
17TYRO31.83261480
18MAPK131.79097358
19BCKDK1.78026746
20STK161.65822833
21PAK31.63415735
22CAMKK11.62425336
23CASK1.62167853
24MAP4K21.58508292
25ADRBK21.50680201
26STK391.46184391
27PRKD31.44923204
28PAK61.43041578
29BRAF1.40264701
30PNCK1.30744455
31MAP3K111.30267608
32TRIM281.29856829
33PRKCG1.27452861
34MAP3K91.21780112
35CAMK11.18258265
36PRKCH1.17328279
37TNIK1.17244608
38SGK4941.04641766
39SGK2231.04641766
40PRKCQ0.95780243
41PIK3CA0.95386080
42DYRK1B0.94114276
43STK30.93681800
44ZAK0.92702228
45TGFBR10.91039631
46BRSK10.90884544
47DMPK0.89800002
48CAMK40.88268733
49MAP2K70.87751473
50NEK20.87599482
51EPHA40.82286924
52PRKCZ0.80620144
53PHKG10.79639542
54PHKG20.79639542
55OXSR10.79198780
56MINK10.78370091
57NTRK10.74767045
58ADRBK10.72388675
59RPS6KA60.71917131
60SGK10.71853917
61DAPK30.71723136
62WNK10.71580315
63AURKA0.70231324
64NME10.69977476
65LIMK10.69059074
66CDK11A0.69030424
67NTRK30.67747461
68SIK20.67404308
69MAPK150.66691067
70BCR0.66600386
71CDK140.66088621
72MAPKAPK50.64938511
73DYRK1A0.63688945
74RPS6KL10.63367398
75RPS6KC10.63367398
76PRKACA0.62429918
77SGK20.62259575
78STK110.62232456
79PIM20.62222290
80RPS6KA20.60186948
81UHMK10.59781833
82ARAF0.57192150
83CDK50.56198135
84CDK80.55043324
85CDK150.54583202
86ABL20.53384888
87TIE10.53299954
88CSNK1E0.50991197
89INSRR0.50302883
90CSNK1G20.49912227
91CHEK20.49775258
92PLK10.49727799
93CDK180.48285886
94DYRK30.47896581
95PDK20.46587730
96MAP3K40.46370809
97CSNK2A20.46102195
98WNK30.45007903
99KSR10.43826625
100MARK20.43786852

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.50223715
2Oxidative phosphorylation_Homo sapiens_hsa001903.58874682
3Sulfur relay system_Homo sapiens_hsa041223.00958350
4Parkinsons disease_Homo sapiens_hsa050122.99062089
5Cardiac muscle contraction_Homo sapiens_hsa042602.96997990
6Huntingtons disease_Homo sapiens_hsa050162.37785127
7Nicotine addiction_Homo sapiens_hsa050332.36228703
8Linoleic acid metabolism_Homo sapiens_hsa005912.21014638
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17502797
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08537831
11Alzheimers disease_Homo sapiens_hsa050102.04505939
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04121096
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03735890
14Phototransduction_Homo sapiens_hsa047442.01835573
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79058296
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71230180
17RNA polymerase_Homo sapiens_hsa030201.55132340
18Butanoate metabolism_Homo sapiens_hsa006501.54208169
19Steroid biosynthesis_Homo sapiens_hsa001001.50013526
20Fanconi anemia pathway_Homo sapiens_hsa034601.35135588
21Fat digestion and absorption_Homo sapiens_hsa049751.30553853
22Homologous recombination_Homo sapiens_hsa034401.30149791
23Protein export_Homo sapiens_hsa030601.26994054
24Basal cell carcinoma_Homo sapiens_hsa052171.22717594
25Glycerolipid metabolism_Homo sapiens_hsa005611.20441392
26Hedgehog signaling pathway_Homo sapiens_hsa043401.19041686
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18475869
28Axon guidance_Homo sapiens_hsa043601.17088005
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15848930
30Morphine addiction_Homo sapiens_hsa050321.14176593
31Notch signaling pathway_Homo sapiens_hsa043301.10122225
32Insulin secretion_Homo sapiens_hsa049111.08974197
33Peroxisome_Homo sapiens_hsa041461.08917274
34Cocaine addiction_Homo sapiens_hsa050301.08652655
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03418317
36Ether lipid metabolism_Homo sapiens_hsa005651.00197246
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96297072
38Tryptophan metabolism_Homo sapiens_hsa003800.93241936
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90017835
40Olfactory transduction_Homo sapiens_hsa047400.88420420
41Basal transcription factors_Homo sapiens_hsa030220.87964280
42Arachidonic acid metabolism_Homo sapiens_hsa005900.86431326
43Collecting duct acid secretion_Homo sapiens_hsa049660.84154760
44RNA degradation_Homo sapiens_hsa030180.83704170
45Ovarian steroidogenesis_Homo sapiens_hsa049130.82780610
46Oxytocin signaling pathway_Homo sapiens_hsa049210.82204313
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78734982
48Pyrimidine metabolism_Homo sapiens_hsa002400.75814387
49Glutamatergic synapse_Homo sapiens_hsa047240.74098111
50Propanoate metabolism_Homo sapiens_hsa006400.73548391
51Caffeine metabolism_Homo sapiens_hsa002320.72963999
52Hippo signaling pathway_Homo sapiens_hsa043900.72944067
53Folate biosynthesis_Homo sapiens_hsa007900.72740658
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72130554
55Taste transduction_Homo sapiens_hsa047420.71908929
56Chemical carcinogenesis_Homo sapiens_hsa052040.71578572
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70067542
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.67054663
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66320022
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.66319367
61Dilated cardiomyopathy_Homo sapiens_hsa054140.62426292
62Fatty acid degradation_Homo sapiens_hsa000710.59905009
63Synaptic vesicle cycle_Homo sapiens_hsa047210.59805226
64Metabolic pathways_Homo sapiens_hsa011000.58912324
65beta-Alanine metabolism_Homo sapiens_hsa004100.58533735
66GABAergic synapse_Homo sapiens_hsa047270.57940848
67Serotonergic synapse_Homo sapiens_hsa047260.57408414
68Long-term depression_Homo sapiens_hsa047300.57186829
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57148835
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56722209
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.56662716
72Selenocompound metabolism_Homo sapiens_hsa004500.52198935
73Cholinergic synapse_Homo sapiens_hsa047250.49071419
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48035425
75Starch and sucrose metabolism_Homo sapiens_hsa005000.47207365
76Base excision repair_Homo sapiens_hsa034100.46271323
77Dorso-ventral axis formation_Homo sapiens_hsa043200.44754846
78Nitrogen metabolism_Homo sapiens_hsa009100.44132361
79Vitamin B6 metabolism_Homo sapiens_hsa007500.43882664
80Circadian entrainment_Homo sapiens_hsa047130.43218948
81Ras signaling pathway_Homo sapiens_hsa040140.42838529
82Melanoma_Homo sapiens_hsa052180.42033300
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41035059
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40130808
85Arginine and proline metabolism_Homo sapiens_hsa003300.37593956
86Dopaminergic synapse_Homo sapiens_hsa047280.37521908
87One carbon pool by folate_Homo sapiens_hsa006700.37233120
88Melanogenesis_Homo sapiens_hsa049160.35137330
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33919320
90MAPK signaling pathway_Homo sapiens_hsa040100.33615541
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33481110
92Retinol metabolism_Homo sapiens_hsa008300.32484700
93cAMP signaling pathway_Homo sapiens_hsa040240.32410566
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.31623695
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31467485
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31038991
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30686558
98Purine metabolism_Homo sapiens_hsa002300.29092034
99ABC transporters_Homo sapiens_hsa020100.27202946
100Wnt signaling pathway_Homo sapiens_hsa043100.26812007

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