ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	5.10745749
2	immunoglobulin mediated immune response (GO:0016064)	4.67150577
3	positive regulation of antigen processing and presentation (GO:0002579)	4.63296755
4	regulation of antigen processing and presentation (GO:0002577)	4.50106075
5	regulation of cellular extravasation (GO:0002691)	4.17231130
6	regulation of dendritic cell antigen processing and presentation (GO:0002604)	4.16380070
7	regulation of guanylate cyclase activity (GO:0031282)	4.02614496
8	DNA deamination (GO:0045006)	3.99159061
9	L-fucose catabolic process (GO:0042355)	3.83711243
10	fucose catabolic process (GO:0019317)	3.83711243
11	L-fucose metabolic process (GO:0042354)	3.83711243
12	B cell mediated immunity (GO:0019724)	3.81802339
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.81703860
14	ATP synthesis coupled proton transport (GO:0015986)	3.81703860
15	antigen processing and presentation of endogenous antigen (GO:0019883)	3.64927963
16	antibacterial humoral response (GO:0019731)	3.54897243
17	preassembly of GPI anchor in ER membrane (GO:0016254)	3.47212378
18	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.46866184
19	tryptophan catabolic process (GO:0006569)	3.45216297
20	indole-containing compound catabolic process (GO:0042436)	3.45216297
21	indolalkylamine catabolic process (GO:0046218)	3.45216297
22	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.39514198
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.38423146
24	water-soluble vitamin biosynthetic process (GO:0042364)	3.38282302
25	kynurenine metabolic process (GO:0070189)	3.36243221
26	antimicrobial humoral response (GO:0019730)	3.35259647
27	positive regulation of prostaglandin secretion (GO:0032308)	3.29362621
28	positive thymic T cell selection (GO:0045059)	3.24035140
29	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.20134241
30	positive regulation of respiratory burst (GO:0060267)	3.16351739
31	positive regulation of guanylate cyclase activity (GO:0031284)	3.16072052
32	cytidine deamination (GO:0009972)	3.15414330
33	cytidine metabolic process (GO:0046087)	3.15414330
34	cytidine catabolic process (GO:0006216)	3.15414330
35	angiotensin maturation (GO:0002003)	3.14784231
36	tryptophan metabolic process (GO:0006568)	3.09527716
37	ribosomal small subunit assembly (GO:0000028)	3.07224071
38	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.03424241
39	respiratory chain complex IV assembly (GO:0008535)	3.03254134
40	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.01789877
41	indolalkylamine metabolic process (GO:0006586)	2.94025503
42	lymphocyte costimulation (GO:0031294)	2.92400251
43	T cell costimulation (GO:0031295)	2.91662533
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.91415229
45	GPI anchor biosynthetic process (GO:0006506)	2.90378074
46	interferon-gamma-mediated signaling pathway (GO:0060333)	2.88662728
47	NADH metabolic process (GO:0006734)	2.88231012
48	sulfation (GO:0051923)	2.87030560
49	drug catabolic process (GO:0042737)	2.83265344
50	electron transport chain (GO:0022900)	2.80443394
51	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.78947884
52	regulation of triglyceride catabolic process (GO:0010896)	2.77858582
53	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.77630446
54	regulation of cGMP biosynthetic process (GO:0030826)	2.77142632
55	respiratory electron transport chain (GO:0022904)	2.75329536
56	regulation of regulatory T cell differentiation (GO:0045589)	2.74825514
57	viral transcription (GO:0019083)	2.74648253
58	GPI anchor metabolic process (GO:0006505)	2.74171862
59	cytochrome complex assembly (GO:0017004)	2.73291351
60	exogenous drug catabolic process (GO:0042738)	2.71793783
61	vitamin biosynthetic process (GO:0009110)	2.69705811
62	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.69363355
63	mannosylation (GO:0097502)	2.66633738
64	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.65995101
65	positive regulation of T-helper 1 type immune response (GO:0002827)	2.65572678
66	regulation of T cell mediated cytotoxicity (GO:0001914)	2.63688820
67	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.60905482
68	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.57811056
69	arginine metabolic process (GO:0006525)	2.56795164
70	response to interferon-beta (GO:0035456)	2.56059132
71	xenobiotic catabolic process (GO:0042178)	2.54034742
72	translational termination (GO:0006415)	2.53650523
73	regulation of prostaglandin secretion (GO:0032306)	2.52453020
74	killing of cells of other organism (GO:0031640)	2.51367233
75	disruption of cells of other organism (GO:0044364)	2.51367233
76	positive regulation of neutrophil chemotaxis (GO:0090023)	2.48339686
77	positive regulation of neutrophil migration (GO:1902624)	2.48339686
78	regulation of immunoglobulin secretion (GO:0051023)	2.48042681
79	positive regulation of activated T cell proliferation (GO:0042104)	2.48030050
80	cellular response to interferon-beta (GO:0035458)	2.48019323
81	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.46776935
82	positive regulation of fatty acid transport (GO:2000193)	2.44697885
83	positive regulation of T cell migration (GO:2000406)	2.44575896
84	T-helper 1 type immune response (GO:0042088)	2.41460767
85	proton transport (GO:0015992)	2.40849862
86	protein targeting to ER (GO:0045047)	2.40647700
87	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.40518509
88	negative regulation of epidermal cell differentiation (GO:0045605)	2.39872961
89	fucosylation (GO:0036065)	2.39838985
90	dendritic cell chemotaxis (GO:0002407)	2.39655657
91	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.39314613
92	cotranslational protein targeting to membrane (GO:0006613)	2.39304439
93	translational elongation (GO:0006414)	2.38449858
94	hydrogen transport (GO:0006818)	2.38300860
95	cellular response to interferon-gamma (GO:0071346)	2.36983222
96	positive regulation of icosanoid secretion (GO:0032305)	2.36718336
97	regulation of inflammatory response to antigenic stimulus (GO:0002861)	2.35775361
98	positive T cell selection (GO:0043368)	2.35382692
99	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.35184513
100	negative regulation of leukocyte migration (GO:0002686)	2.34735801

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	5.44390682
2	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	4.11170081
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.02970238
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.30560272
5	VDR_22108803_ChIP-Seq_LS180_Human	3.11793757
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85412104
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.80792664
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.54619161
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.50007607
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.42346172
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.23925744
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.20122953
13	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.92863042
14	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.84783651
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84218672
16	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.83191827
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.81977459
18	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.80417179
19	GATA3_26560356_Chip-Seq_TH2_Human	1.77648269
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76415167
21	AR_20517297_ChIP-Seq_VCAP_Human	1.58285035
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.57590017
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55677630
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.52686201
25	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.52003309
26	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.51749144
27	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50943714
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50943714
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.49576404
30	STAT1_20625510_ChIP-Seq_HELA_Human	1.49052339
31	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.49047354
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44577393
33	RUNX_20019798_ChIP-Seq_JUKART_Human	1.40606828
34	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40146892
35	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.39919873
36	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.38866793
37	MYC_19829295_ChIP-Seq_ESCs_Human	1.36044302
38	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35904488
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34701539
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34568694
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34568694
42	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.33659412
43	P300_27268052_Chip-Seq_Bcells_Human	1.32502421
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.32402560
45	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31703602
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.31126547
47	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.31069393
48	CIITA_25753668_ChIP-Seq_RAJI_Human	1.29671385
49	MYB_26560356_Chip-Seq_TH2_Human	1.29497748
50	BCL6_27268052_Chip-Seq_Bcells_Human	1.29400402
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28582256
52	GATA4_25053715_ChIP-Seq_YYC3_Human	1.28577881
53	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27999780
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.26989738
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26758650
56	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25807443
57	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.25693739
58	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.24445898
59	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.24265098
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.23757161
61	E2F1_20622854_ChIP-Seq_HELA_Human	1.21251057
62	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20693569
63	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20199655
64	NCOR_22424771_ChIP-Seq_293T_Human	1.19738354
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19712456
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18226373
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17749804
68	ERA_21632823_ChIP-Seq_H3396_Human	1.17714975
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.15651627
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.15091166
71	CEBPB_22108803_ChIP-Seq_LS180_Human	1.14657020
72	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.13805002
73	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.12927387
74	EWS_26573619_Chip-Seq_HEK293_Human	1.12754233
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12426000
76	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.12088769
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11036169
78	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.10522602
79	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.10311958
80	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.10226397
81	SPI1_23547873_ChIP-Seq_NB4_Human	1.09495166
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09387601
83	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07904613
84	GATA3_27048872_Chip-Seq_THYMUS_Human	1.07733156
85	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.07260917
86	BCAT_22108803_ChIP-Seq_LS180_Human	1.05912511
87	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.03482321
88	P53_21459846_ChIP-Seq_SAOS-2_Human	1.02864429
89	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02740392
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.02323164
91	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01910179
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00676919
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99941876
94	FUS_26573619_Chip-Seq_HEK293_Human	0.99678564
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.99214424
96	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.99069658
97	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.97610899
98	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.97557596
99	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96615496
100	RAC3_21632823_ChIP-Seq_H3396_Human	0.95974127

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.04301307
2	MP0005360_urolithiasis	3.72193279
3	MP0002138_abnormal_hepatobiliary_system	3.67160603
4	MP0003806_abnormal_nucleotide_metabolis	3.26908393
5	MP0009379_abnormal_foot_pigmentation	3.17702011
6	MP0005671_abnormal_response_to	3.02188030
7	MP0000685_abnormal_immune_system	2.67262185
8	MP0004147_increased_porphyrin_level	2.53037822
9	MP0010155_abnormal_intestine_physiology	2.48758891
10	MP0003724_increased_susceptibility_to	2.45183232
11	MP0002139_abnormal_hepatobiliary_system	2.38585632
12	MP0002148_abnormal_hypersensitivity_rea	2.23201610
13	MP0005085_abnormal_gallbladder_physiolo	2.16809933
14	MP0001800_abnormal_humoral_immune	2.15950146
15	MP0001873_stomach_inflammation	2.14251303
16	MP0002166_altered_tumor_susceptibility	2.08646584
17	MP0001790_abnormal_immune_system	2.07442355
18	MP0005387_immune_system_phenotype	2.07442355
19	MP0001666_abnormal_nutrient_absorption	1.97205436
20	MP0005000_abnormal_immune_tolerance	1.93070001
21	MP0008872_abnormal_physiological_respon	1.91679138
22	MP0009764_decreased_sensitivity_to	1.85448179
23	MP0009785_altered_susceptibility_to	1.82692196
24	MP0003866_abnormal_defecation	1.82099142
25	MP0002876_abnormal_thyroid_physiology	1.77119474
26	MP0004019_abnormal_vitamin_homeostasis	1.75901118
27	MP0008875_abnormal_xenobiotic_pharmacok	1.73777603
28	MP0005645_abnormal_hypothalamus_physiol	1.69521145
29	MP0003718_maternal_effect	1.65217995
30	MP0002723_abnormal_immune_serum	1.64434762
31	MP0003436_decreased_susceptibility_to	1.64328697
32	MP0002006_tumorigenesis	1.60922009
33	MP0008775_abnormal_heart_ventricle	1.58668461
34	MP0002452_abnormal_antigen_presenting	1.57424892
35	MP0003252_abnormal_bile_duct	1.55922546
36	MP0003646_muscle_fatigue	1.51932843
37	MP0001845_abnormal_inflammatory_respons	1.47952576
38	MP0001819_abnormal_immune_cell	1.46835920
39	MP0002420_abnormal_adaptive_immunity	1.45568865
40	MP0001986_abnormal_taste_sensitivity	1.45437228
41	MP0003195_calcinosis	1.41313784
42	MP0005332_abnormal_amino_acid	1.41154015
43	MP0005365_abnormal_bile_salt	1.38497420
44	MP0006036_abnormal_mitochondrial_physio	1.36759209
45	MP0001663_abnormal_digestive_system	1.35969113
46	MP0005025_abnormal_response_to	1.34553368
47	MP0000465_gastrointestinal_hemorrhage	1.31714523
48	MP0009643_abnormal_urine_homeostasis	1.30504650
49	MP0005166_decreased_susceptibility_to	1.30105609
50	MP0006072_abnormal_retinal_apoptosis	1.28742224
51	MP0003763_abnormal_thymus_physiology	1.27419628
52	MP0009333_abnormal_splenocyte_physiolog	1.25448884
53	MP0008877_abnormal_DNA_methylation	1.23406677
54	MP0002102_abnormal_ear_morphology	1.23380230
55	MP0010329_abnormal_lipoprotein_level	1.19154454
56	MP0001765_abnormal_ion_homeostasis	1.17461472
57	MP0005075_abnormal_melanosome_morpholog	1.09529972
58	MP0001764_abnormal_homeostasis	1.07171364
59	MP0008469_abnormal_protein_level	1.07030525
60	MP0003183_abnormal_peptide_metabolism	1.06366745
61	MP0001501_abnormal_sleep_pattern	1.05817391
62	MP0004782_abnormal_surfactant_physiolog	1.04955136
63	MP0000716_abnormal_immune_system	1.03927944
64	MP0003011_delayed_dark_adaptation	1.03639228
65	MP0004043_abnormal_pH_regulation	1.03231722
66	MP0001664_abnormal_digestion	1.02185633
67	MP0003303_peritoneal_inflammation	1.00306311
68	MP0001968_abnormal_touch/_nociception	0.97667730
69	MP0002837_dystrophic_cardiac_calcinosis	0.97271656
70	MP0005636_abnormal_mineral_homeostasis	0.96399327
71	MP0000372_irregular_coat_pigmentation	0.95053557
72	MP0000230_abnormal_systemic_arterial	0.94886020
73	MP0002136_abnormal_kidney_physiology	0.92256774
74	MP0001533_abnormal_skeleton_physiology	0.92249489
75	MP0000689_abnormal_spleen_morphology	0.90584134
76	MP0005381_digestive/alimentary_phenotyp	0.90285511
77	MP0002398_abnormal_bone_marrow	0.89134162
78	MP0003638_abnormal_response/metabolism_	0.88733048
79	MP0002419_abnormal_innate_immunity	0.88474725
80	MP0004885_abnormal_endolymph	0.87431997
81	MP0005551_abnormal_eye_electrophysiolog	0.87135540
82	MP0000013_abnormal_adipose_tissue	0.86752068
83	MP0004145_abnormal_muscle_electrophysio	0.86669336
84	MP0000490_abnormal_crypts_of	0.85000140
85	MP0000538_abnormal_urinary_bladder	0.83292862
86	MP0000516_abnormal_urinary_system	0.82875143
87	MP0005367_renal/urinary_system_phenotyp	0.82875143
88	MP0001756_abnormal_urination	0.82063319
89	MP0002429_abnormal_blood_cell	0.79095101
90	MP0003786_premature_aging	0.77578917
91	MP0006082_CNS_inflammation	0.77405700
92	MP0002277_abnormal_respiratory_mucosa	0.76028703
93	MP0001905_abnormal_dopamine_level	0.75520595
94	MP0002405_respiratory_system_inflammati	0.74011239
95	MP0000427_abnormal_hair_cycle	0.73423957
96	MP0001919_abnormal_reproductive_system	0.71344239
97	MP0000477_abnormal_intestine_morphology	0.70926354
98	MP0002736_abnormal_nociception_after	0.70542143
99	MP0005646_abnormal_pituitary_gland	0.69366004
100	MP0005448_abnormal_energy_balance	0.68877206

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.00061921
2	Chronic diarrhea (HP:0002028)	3.74669218
3	Congenital, generalized hypertrichosis (HP:0004540)	3.69246979
4	Elevated erythrocyte sedimentation rate (HP:0003565)	3.36920730
5	IgG deficiency (HP:0004315)	3.31039338
6	Lipid accumulation in hepatocytes (HP:0006561)	3.16559734
7	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.15622746
8	Mitochondrial inheritance (HP:0001427)	3.11950277
9	Acute necrotizing encephalopathy (HP:0006965)	3.05017061
10	Abnormality of vitamin B metabolism (HP:0004340)	2.98325249
11	Glycosuria (HP:0003076)	2.91953922
12	Abnormality of urine glucose concentration (HP:0011016)	2.91953922
13	Abnormality of B cell number (HP:0010975)	2.89853364
14	Hydroxyprolinuria (HP:0003080)	2.86642476
15	Abnormality of proline metabolism (HP:0010907)	2.86642476
16	Abnormality of the prostate (HP:0008775)	2.86307717
17	Acute encephalopathy (HP:0006846)	2.85398224
18	Agammaglobulinemia (HP:0004432)	2.84405617
19	Increased CSF lactate (HP:0002490)	2.83548538
20	Hepatocellular necrosis (HP:0001404)	2.81733810
21	Abnormality of T cell physiology (HP:0011840)	2.75828183
22	Methylmalonic aciduria (HP:0012120)	2.74461465
23	Hepatic necrosis (HP:0002605)	2.72697561
24	Increased hepatocellular lipid droplets (HP:0006565)	2.70423586
25	Progressive macrocephaly (HP:0004481)	2.69424289
26	Congenital stationary night blindness (HP:0007642)	2.68608709
27	Lethargy (HP:0001254)	2.64977653
28	Abnormal mitochondria in muscle tissue (HP:0008316)	2.63189837
29	Panhypogammaglobulinemia (HP:0003139)	2.62239648
30	Abolished electroretinogram (ERG) (HP:0000550)	2.59667009
31	Nausea (HP:0002018)	2.53799096
32	Stomatitis (HP:0010280)	2.51662489
33	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.51178365
34	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.50419377
35	Dicarboxylic aciduria (HP:0003215)	2.50419377
36	Hyperglycinuria (HP:0003108)	2.47850576
37	Stomach cancer (HP:0012126)	2.44381966
38	Alkalosis (HP:0001948)	2.38628628
39	Abnormality of glycine metabolism (HP:0010895)	2.37189394
40	Abnormality of serine family amino acid metabolism (HP:0010894)	2.37189394
41	Metabolic alkalosis (HP:0200114)	2.34300206
42	3-Methylglutaconic aciduria (HP:0003535)	2.33826143
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.33660955
44	Methylmalonic acidemia (HP:0002912)	2.31532543
45	Decreased circulating renin level (HP:0003351)	2.29778359
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.29529316
47	Abnormality of T cells (HP:0002843)	2.28793224
48	Vasculitis (HP:0002633)	2.27080418
49	Cerebral edema (HP:0002181)	2.26131630
50	Lactic acidosis (HP:0003128)	2.25931887
51	Pigmentary retinal degeneration (HP:0001146)	2.24010551
52	Congenital sensorineural hearing impairment (HP:0008527)	2.21813378
53	Increased muscle lipid content (HP:0009058)	2.18137969
54	Renal Fanconi syndrome (HP:0001994)	2.16492854
55	Pustule (HP:0200039)	2.15598115
56	Delayed CNS myelination (HP:0002188)	2.14628592
57	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.14597475
58	B lymphocytopenia (HP:0010976)	2.14459886
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.11680935
60	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.11680935
61	Hyperphosphaturia (HP:0003109)	2.11271919
62	Hypoproteinemia (HP:0003075)	2.11248146
63	Pulmonary infiltrates (HP:0002113)	2.10944574
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.10022604
65	Increased serum lactate (HP:0002151)	2.09713708
66	Systemic lupus erythematosus (HP:0002725)	2.09418374
67	Hypothermia (HP:0002045)	2.07624881
68	Increased IgM level (HP:0003496)	2.07262008
69	Malnutrition (HP:0004395)	2.06579326
70	Metabolic acidosis (HP:0001942)	2.05632830
71	Abnormality of cells of the erythroid lineage (HP:0012130)	2.05373204
72	Meningitis (HP:0001287)	2.03802210
73	Abnormality of magnesium homeostasis (HP:0004921)	2.03447606
74	Exertional dyspnea (HP:0002875)	2.01993355
75	Facial diplegia (HP:0001349)	2.01854650
76	Pancreatitis (HP:0001733)	2.01519110
77	Recurrent bronchitis (HP:0002837)	2.00846137
78	Myositis (HP:0100614)	2.00652943
79	Abnormal number of erythroid precursors (HP:0012131)	1.97544016
80	Abnormality of the renal cortex (HP:0011035)	1.96099455
81	Increased intramyocellular lipid droplets (HP:0012240)	1.93898738
82	Type 2 muscle fiber atrophy (HP:0003554)	1.93862605
83	Macrocytic anemia (HP:0001972)	1.93598442
84	Pancreatic cysts (HP:0001737)	1.92394302
85	Facial shape deformation (HP:0011334)	1.91935614
86	Potter facies (HP:0002009)	1.91935614
87	Optic disc pallor (HP:0000543)	1.90934075
88	Hyperglycinemia (HP:0002154)	1.89617596
89	Hemoptysis (HP:0002105)	1.89575180
90	Abnormality of vitamin metabolism (HP:0100508)	1.89354243
91	Respiratory failure (HP:0002878)	1.87342427
92	Hypoalbuminemia (HP:0003073)	1.86634112
93	Abnormal albumin level (HP:0012116)	1.86634112
94	Chronic otitis media (HP:0000389)	1.83904771
95	Abnormal drinking behavior (HP:0030082)	1.81611251
96	Polydipsia (HP:0001959)	1.81611251
97	IgM deficiency (HP:0002850)	1.81052368
98	Abnormal urine output (HP:0012590)	1.80015402
99	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78645119
100	Cerebral palsy (HP:0100021)	1.78514167

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.11185037
2	MAP4K2	3.02590299
3	MAP4K1	2.99131760
4	ZAK	2.97462459
5	ACVR1B	2.95761751
6	ADRBK2	2.90085268
7	TXK	2.78475071
8	FRK	2.52890746
9	TAOK3	2.40112133
10	GRK1	2.33180494
11	KIT	2.31388009
12	TIE1	2.24276052
13	NUAK1	2.12639055
14	TEC	1.86048254
15	MAP2K2	1.82435790
16	MST4	1.67358469
17	WNK4	1.65182470
18	MAP3K12	1.64652174
19	CDK8	1.64249730
20	CDK19	1.58721122
21	SYK	1.58621492
22	OXSR1	1.56702764
23	GRK6	1.54239621
24	ERN1	1.47829279
25	EIF2AK3	1.47711183
26	VRK2	1.41202269
27	IKBKE	1.35402870
28	FES	1.35043773
29	ITK	1.32114005
30	STK39	1.30164774
31	IKBKB	1.26803842
32	STK16	1.24917158
33	RIPK4	1.22047451
34	CSF1R	1.20474637
35	BCKDK	1.19085782
36	MYLK	1.13699759
37	TBK1	1.12442682
38	KDR	1.12329160
39	BMPR2	1.11404359
40	LYN	1.10931675
41	BMPR1B	1.07896581
42	MAPKAPK3	1.05187354
43	WNK3	1.04810322
44	PINK1	1.00379289
45	NEK1	1.00091787
46	PHKG1	0.99080042
47	PHKG2	0.99080042
48	JAK3	0.98664597
49	BTK	0.97547447
50	DAPK2	0.89826536
51	MAP2K6	0.88443991
52	RPS6KA5	0.84702622
53	TRIM28	0.84102996
54	MKNK1	0.83640964
55	MATK	0.82826837
56	PASK	0.82704622
57	PDK2	0.81725615
58	TESK2	0.80581820
59	LCK	0.79988216
60	MAPKAPK5	0.75048424
61	INSRR	0.74951901
62	PLK4	0.73477206
63	PRKCQ	0.72255667
64	ERBB3	0.71995617
65	ADRBK1	0.71620659
66	MAP3K14	0.71056268
67	VRK1	0.67275340
68	DYRK2	0.63996256
69	PLK2	0.63421061
70	TNK2	0.60723479
71	PRKG2	0.57946445
72	IGF1R	0.56203378
73	ABL1	0.54471807
74	DAPK1	0.54061164
75	PRKCA	0.53998894
76	CSNK1G3	0.53890405
77	PIK3CA	0.51491450
78	FLT3	0.47053037
79	SCYL2	0.45823426
80	HCK	0.44497436
81	MAPK13	0.42524148
82	TYK2	0.41372136
83	PIM1	0.41274900
84	CSK	0.41005472
85	NLK	0.40539517
86	PRKCE	0.40193647
87	CSNK1A1	0.39747850
88	GRK5	0.38543360
89	MKNK2	0.38416017
90	TGFBR1	0.38300660
91	PRKACG	0.37891940
92	PRKACA	0.37821441
93	CSNK2A1	0.37315065
94	PRKCD	0.36886437
95	CHUK	0.33413203
96	CSNK2A2	0.33318632
97	ILK	0.33248921
98	RPS6KB2	0.33033677
99	CSNK1G2	0.31931608
100	DAPK3	0.31898863

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.33776455
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.25621225
3	Allograft rejection_Homo sapiens_hsa05330	4.18525987
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.98835478
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.70874840
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.40244528
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.37605748
8	Fat digestion and absorption_Homo sapiens_hsa04975	2.26789263
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.17194776
10	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.13791272
11	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.05319090
12	Linoleic acid metabolism_Homo sapiens_hsa00591	2.00754450
13	Caffeine metabolism_Homo sapiens_hsa00232	1.90767181
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87000716
15	Viral myocarditis_Homo sapiens_hsa05416	1.86251671
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.82634534
17	Ribosome_Homo sapiens_hsa03010	1.78310942
18	Proteasome_Homo sapiens_hsa03050	1.74509001
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.72770779
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.66526191
21	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.66439419
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.47990691
23	Parkinsons disease_Homo sapiens_hsa05012	1.44933613
24	Leishmaniasis_Homo sapiens_hsa05140	1.44430508
25	Sulfur metabolism_Homo sapiens_hsa00920	1.42911472
26	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.41832368
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.32503226
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.22109208
29	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.17866252
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.15430697
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14815111
32	Renin-angiotensin system_Homo sapiens_hsa04614	0.97094823
33	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.94181611
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90102729
35	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.89981864
36	Protein export_Homo sapiens_hsa03060	0.89158579
37	Alzheimers disease_Homo sapiens_hsa05010	0.89065459
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87343435
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.86370847
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.84960527
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82750430
42	Retinol metabolism_Homo sapiens_hsa00830	0.81908258
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81285156
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79496531
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78126715
46	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.74784094
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.74392640
48	Mineral absorption_Homo sapiens_hsa04978	0.73537883
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72027882
50	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67028545
51	Phototransduction_Homo sapiens_hsa04744	0.66841790
52	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66581118
53	Propanoate metabolism_Homo sapiens_hsa00640	0.66061619
54	Toxoplasmosis_Homo sapiens_hsa05145	0.65001950
55	Huntingtons disease_Homo sapiens_hsa05016	0.63867051
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63776873
57	Herpes simplex infection_Homo sapiens_hsa05168	0.60754144
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60726288
59	Fatty acid degradation_Homo sapiens_hsa00071	0.60235511
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.58897045
61	Histidine metabolism_Homo sapiens_hsa00340	0.57589989
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57077033
63	Sulfur relay system_Homo sapiens_hsa04122	0.52542560
64	Glutathione metabolism_Homo sapiens_hsa00480	0.51948071
65	Peroxisome_Homo sapiens_hsa04146	0.51665342
66	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48894777
67	RNA polymerase_Homo sapiens_hsa03020	0.48681095
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.48560891
69	Homologous recombination_Homo sapiens_hsa03440	0.47481873
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.45993295
71	Tuberculosis_Homo sapiens_hsa05152	0.45836221
72	RNA degradation_Homo sapiens_hsa03018	0.44014321
73	Butanoate metabolism_Homo sapiens_hsa00650	0.43553206
74	One carbon pool by folate_Homo sapiens_hsa00670	0.43273197
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42515305
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.42392043
77	PPAR signaling pathway_Homo sapiens_hsa03320	0.38709424
78	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38663165
79	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.37941749
80	Metabolic pathways_Homo sapiens_hsa01100	0.33962225
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.31852372
82	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.31452414
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31003238
84	Purine metabolism_Homo sapiens_hsa00230	0.28880335
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.27097534
86	Phagosome_Homo sapiens_hsa04145	0.26095993
87	Influenza A_Homo sapiens_hsa05164	0.25816902
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.25417440
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.24693534
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.22682973
91	Pancreatic secretion_Homo sapiens_hsa04972	0.22333732
92	Olfactory transduction_Homo sapiens_hsa04740	0.21592622
93	Base excision repair_Homo sapiens_hsa03410	0.21531226
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.21220363
95	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.21150919
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.21089563
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.20401761
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.19996942
99	Regulation of autophagy_Homo sapiens_hsa04140	0.19941340
100	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.19392289

EEF1A1P42

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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