EEF1A1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.46587289
2protein maturation by protein folding (GO:0022417)4.26800573
3chaperone mediated protein folding requiring cofactor (GO:0051085)4.17427072
4formation of translation preinitiation complex (GO:0001731)4.12754102
5peptidyl-arginine omega-N-methylation (GO:0035247)4.12118547
6chromatin assembly (GO:0031497)3.96021339
7COPI coating of Golgi vesicle (GO:0048205)3.80620272
8Golgi transport vesicle coating (GO:0048200)3.80620272
9regulation of translational termination (GO:0006449)3.78272094
10viral mRNA export from host cell nucleus (GO:0046784)3.69669510
11negative regulation of B cell apoptotic process (GO:0002903)3.47166388
12innate immune response in mucosa (GO:0002227)3.46621437
13positive regulation of T cell mediated cytotoxicity (GO:0001916)3.44187945
14ribosome assembly (GO:0042255)3.43267669
15peptidyl-arginine methylation (GO:0018216)3.36083692
16peptidyl-arginine N-methylation (GO:0035246)3.36083692
17DNA strand elongation involved in DNA replication (GO:0006271)3.32025675
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26870826
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.24430065
20antigen processing and presentation of endogenous antigen (GO:0019883)3.23803825
21ribosome biogenesis (GO:0042254)3.22262326
22establishment of viral latency (GO:0019043)3.22054570
23DNA deamination (GO:0045006)3.20867689
24DNA strand elongation (GO:0022616)3.19615300
25histone arginine methylation (GO:0034969)3.11329129
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10063804
27establishment of integrated proviral latency (GO:0075713)3.05058776
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98597763
29glomerular basement membrane development (GO:0032836)2.97511467
30immunoglobulin mediated immune response (GO:0016064)2.95852689
31positive regulation of prostaglandin secretion (GO:0032308)2.92896555
32DNA replication-dependent nucleosome assembly (GO:0006335)2.89195614
33DNA replication-dependent nucleosome organization (GO:0034723)2.89195614
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87052425
35actin-myosin filament sliding (GO:0033275)2.86770804
36muscle filament sliding (GO:0030049)2.86770804
37regulation of T cell mediated cytotoxicity (GO:0001914)2.77014858
38UTP biosynthetic process (GO:0006228)2.76282545
39telomere maintenance via semi-conservative replication (GO:0032201)2.73518529
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73325459
41skeletal muscle contraction (GO:0003009)2.72015839
42signal transduction involved in DNA damage checkpoint (GO:0072422)2.71829417
43signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71829417
44B cell mediated immunity (GO:0019724)2.69708892
45mucosal immune response (GO:0002385)2.67731550
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65815033
47signal transduction involved in cell cycle checkpoint (GO:0072395)2.64889373
48antibacterial humoral response (GO:0019731)2.64191584
49base-excision repair (GO:0006284)2.61877480
50cellular response to interleukin-4 (GO:0071353)2.61726900
51proline biosynthetic process (GO:0006561)2.60268386
52positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58250218
53muscle cell migration (GO:0014812)2.57799260
54mitochondrial RNA metabolic process (GO:0000959)2.56992607
55guanosine-containing compound biosynthetic process (GO:1901070)2.56945560
56positive regulation of cell killing (GO:0031343)2.56538832
57ribonucleoprotein complex biogenesis (GO:0022613)2.54913215
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.54396843
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.54396843
60NIK/NF-kappaB signaling (GO:0038061)2.53937844
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.51688281
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.51688281
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.51688281
64pseudouridine synthesis (GO:0001522)2.51188251
65antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.50923050
66DNA replication initiation (GO:0006270)2.50323189
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50061465
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.49068092
69positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.48716629
70GDP-mannose metabolic process (GO:0019673)2.48164378
71AMP metabolic process (GO:0046033)2.46854580
72negative thymic T cell selection (GO:0045060)2.46362618
73positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.45742487
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45580546
75UTP metabolic process (GO:0046051)2.44211126
76regulation of mitochondrial translation (GO:0070129)2.44011805
77regulation of prostaglandin secretion (GO:0032306)2.43241457
78antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42962341
79positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.42143863
80ribosomal large subunit biogenesis (GO:0042273)2.40814723
81regulation of cellular amino acid metabolic process (GO:0006521)2.40692901
82regulation of B cell apoptotic process (GO:0002902)2.40598222
83ribosomal small subunit assembly (GO:0000028)2.40012566
84thymic T cell selection (GO:0045061)2.39721628
85GTP biosynthetic process (GO:0006183)2.39283286
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.38186552
87peptidyl-arginine modification (GO:0018195)2.38002378
88positive regulation of myotube differentiation (GO:0010831)2.37283523
89mitotic nuclear envelope reassembly (GO:0007084)2.36641471
90nuclear envelope reassembly (GO:0031468)2.36641471
91actin-mediated cell contraction (GO:0070252)2.36560845
92glycolytic process (GO:0006096)2.36540076
93positive thymic T cell selection (GO:0045059)2.36401524
94negative T cell selection (GO:0043383)2.36147076
95antimicrobial humoral response (GO:0019730)2.34675617
96rRNA processing (GO:0006364)2.34574072
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.34166821
98negative regulation of ligase activity (GO:0051352)2.34166821
99Arp2/3 complex-mediated actin nucleation (GO:0034314)2.33884197
100regulation of protein heterodimerization activity (GO:0043497)2.33308553

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.97987976
2E2F7_22180533_ChIP-Seq_HELA_Human4.97100602
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34561074
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.85228952
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74459200
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63782133
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58264963
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56135987
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49311669
10MYC_22102868_ChIP-Seq_BL_Human2.39289384
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35273839
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29457219
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25294457
14ZNF263_19887448_ChIP-Seq_K562_Human2.23232316
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20594138
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.15224068
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05756739
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05159168
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03581356
20HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse2.01660298
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.96260413
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.95151426
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92789984
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92273281
25VDR_23849224_ChIP-Seq_CD4+_Human1.89664890
26CIITA_25753668_ChIP-Seq_RAJI_Human1.88707907
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86135079
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84959763
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80509330
30DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79122083
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.77453506
32VDR_21846776_ChIP-Seq_THP-1_Human1.77210825
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.73085530
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72164596
35XRN2_22483619_ChIP-Seq_HELA_Human1.70532572
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68977623
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.68455686
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67245861
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66503373
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.65990001
41FOXP3_21729870_ChIP-Seq_TREG_Human1.65652971
42MAF_26560356_Chip-Seq_TH1_Human1.64278504
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63324835
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62797222
45DCP1A_22483619_ChIP-Seq_HELA_Human1.61531430
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60449215
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.60294417
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.59864521
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.55946691
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.55824456
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.53367753
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51968610
53CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.48022737
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45611003
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44422269
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.40072895
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36360928
58GABP_19822575_ChIP-Seq_HepG2_Human1.35554550
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.34395754
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32761133
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32639315
62MYB_26560356_Chip-Seq_TH2_Human1.32299286
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31849950
64ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29850803
65MYB_26560356_Chip-Seq_TH1_Human1.27625546
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.24989888
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23608389
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22001677
69ELK1_19687146_ChIP-ChIP_HELA_Human1.20722777
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.20284455
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20025824
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19731063
73TTF2_22483619_ChIP-Seq_HELA_Human1.18891067
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16357638
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15756923
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14854841
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14618443
78UTX_26944678_Chip-Seq_JUKART_Human1.13846977
79KDM5A_27292631_Chip-Seq_BREAST_Human1.11439676
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11037995
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.08893434
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08717932
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08217593
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07694430
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07600200
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05490605
87SPI1_23547873_ChIP-Seq_NB4_Human1.05295282
88TFEB_21752829_ChIP-Seq_HELA_Human1.04483504
89MAF_26560356_Chip-Seq_TH2_Human1.03247215
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03115325
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00710738
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98858389
93MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98782375
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96856353
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93364616
96ATF3_27146783_Chip-Seq_COLON_Human0.93132443
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92600372
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.91130807
99VDR_24763502_ChIP-Seq_THP-1_Human0.90013678
100EGR1_19374776_ChIP-ChIP_THP-1_Human0.89778551

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.43699525
2MP0005645_abnormal_hypothalamus_physiol2.92138538
3MP0002166_altered_tumor_susceptibility2.87101020
4MP0000685_abnormal_immune_system2.78007018
5MP0005671_abnormal_response_to2.64807810
6MP0003763_abnormal_thymus_physiology2.60639634
7MP0004272_abnormal_basement_membrane2.46681510
8MP0002006_tumorigenesis2.41591482
9MP0010094_abnormal_chromosome_stability2.33171843
10MP0001835_abnormal_antigen_presentation2.19009638
11MP0002877_abnormal_melanocyte_morpholog2.18769056
12MP0000751_myopathy2.15515971
13MP0005257_abnormal_intraocular_pressure2.00460699
14MP0005275_abnormal_skin_tensile1.99407868
15MP0003693_abnormal_embryo_hatching1.96666501
16MP0003111_abnormal_nucleus_morphology1.89942041
17MP0004957_abnormal_blastocyst_morpholog1.82446131
18MP0001661_extended_life_span1.70930290
19MP0000749_muscle_degeneration1.70368005
20MP0003077_abnormal_cell_cycle1.67267033
21MP0002060_abnormal_skin_morphology1.62223718
22MP0001800_abnormal_humoral_immune1.57778831
23MP0000747_muscle_weakness1.56833509
24MP0009333_abnormal_splenocyte_physiolog1.55812516
25MP0002163_abnormal_gland_morphology1.51262652
26MP0000750_abnormal_muscle_regeneration1.50476528
27MP0005000_abnormal_immune_tolerance1.47977280
28MP0003786_premature_aging1.46164015
29MP0000733_abnormal_muscle_development1.45765914
30MP0008058_abnormal_DNA_repair1.44544761
31MP0008007_abnormal_cellular_replicative1.42869760
32MP0002398_abnormal_bone_marrow1.42346326
33MP0001790_abnormal_immune_system1.42169505
34MP0005387_immune_system_phenotype1.42169505
35MP0005451_abnormal_body_composition1.41271685
36MP0002138_abnormal_hepatobiliary_system1.39914116
37MP0005623_abnormal_meninges_morphology1.34890276
38MP0010234_abnormal_vibrissa_follicle1.30542010
39MP0002452_abnormal_antigen_presenting1.28340706
40MP0002420_abnormal_adaptive_immunity1.27737574
41MP0000759_abnormal_skeletal_muscle1.26586040
42MP0002019_abnormal_tumor_incidence1.25145012
43MP0002723_abnormal_immune_serum1.24691371
44MP0001819_abnormal_immune_cell1.24110204
45MP0010352_gastrointestinal_tract_polyps1.23949698
46MP0000490_abnormal_crypts_of1.19414327
47MP0002722_abnormal_immune_system1.18539739
48MP0001873_stomach_inflammation1.17133294
49MP0003950_abnormal_plasma_membrane1.17033031
50MP0000689_abnormal_spleen_morphology1.15486730
51MP0010155_abnormal_intestine_physiology1.11565769
52MP0000716_abnormal_immune_system1.10464641
53MP0002429_abnormal_blood_cell1.09878074
54MP0000350_abnormal_cell_proliferation1.08898761
55MP0003806_abnormal_nucleotide_metabolis1.08369778
56MP0002396_abnormal_hematopoietic_system1.07583109
57MP0000537_abnormal_urethra_morphology1.05650444
58MP0000703_abnormal_thymus_morphology1.05422842
59MP0004087_abnormal_muscle_fiber1.04069339
60MP0004134_abnormal_chest_morphology1.03661871
61MP0005377_hearing/vestibular/ear_phenot1.02852300
62MP0003878_abnormal_ear_physiology1.02852300
63MP0002148_abnormal_hypersensitivity_rea1.02792078
64MP0000613_abnormal_salivary_gland1.00578188
65MP0002269_muscular_atrophy0.99759108
66MP0005464_abnormal_platelet_physiology0.97248270
67MP0001730_embryonic_growth_arrest0.96885787
68MP0002009_preneoplasia0.95941084
69MP0009785_altered_susceptibility_to0.93752782
70MP0003436_decreased_susceptibility_to0.93563807
71MP0008932_abnormal_embryonic_tissue0.92706017
72MP0000013_abnormal_adipose_tissue0.92488310
73MP0003566_abnormal_cell_adhesion0.91651586
74MP0004145_abnormal_muscle_electrophysio0.91496772
75MP0009697_abnormal_copulation0.88679622
76MP0002106_abnormal_muscle_physiology0.86278106
77MP0005025_abnormal_response_to0.86177962
78MP0002102_abnormal_ear_morphology0.85119470
79MP0001845_abnormal_inflammatory_respons0.84990800
80MP0005330_cardiomyopathy0.84930958
81MP0000858_altered_metastatic_potential0.84757493
82MP0003183_abnormal_peptide_metabolism0.83465980
83MP0003045_fibrosis0.82154806
84MP0004510_myositis0.82028766
85MP0005220_abnormal_exocrine_pancreas0.81485179
86MP0000358_abnormal_cell_content/0.81117416
87MP0002089_abnormal_postnatal_growth/wei0.79324428
88MP0002080_prenatal_lethality0.79278229
89MP0001542_abnormal_bone_strength0.79188385
90MP0010030_abnormal_orbit_morphology0.78816524
91MP0005165_increased_susceptibility_to0.76941735
92MP0000313_abnormal_cell_death0.76270805
93MP0005369_muscle_phenotype0.73879264
94MP0001243_abnormal_dermal_layer0.73304991
95MP0010368_abnormal_lymphatic_system0.70500125
96MP0002108_abnormal_muscle_morphology0.70103106
97MP0001727_abnormal_embryo_implantation0.68873193
98MP0001849_ear_inflammation0.68131207
99MP0001348_abnormal_lacrimal_gland0.68126192
100MP0005503_abnormal_tendon_morphology0.67693863

Predicted human phenotypes

RankGene SetZ-score
1Distal arthrogryposis (HP:0005684)8.17305183
2Round ear (HP:0100830)6.09815064
3Trismus (HP:0000211)5.88698528
4Ulnar deviation of the wrist (HP:0003049)5.55206763
5Calcaneovalgus deformity (HP:0001848)5.25894352
6Deformed tarsal bones (HP:0008119)4.67410607
7Absent phalangeal crease (HP:0006109)4.59103089
8Breech presentation (HP:0001623)4.53043296
9Onycholysis (HP:0001806)4.15308645
10Abnormal finger flexion creases (HP:0006143)3.93865409
11Gastrointestinal stroma tumor (HP:0100723)3.73454983
12Metatarsus adductus (HP:0001840)3.33759936
13Abnormality of the calcaneus (HP:0008364)3.30754313
14IgM deficiency (HP:0002850)3.19466769
15Malignant hyperthermia (HP:0002047)3.13070377
16IgA deficiency (HP:0002720)3.08253259
17Agammaglobulinemia (HP:0004432)3.04095406
18Conical tooth (HP:0000698)2.90331925
19Premature rupture of membranes (HP:0001788)2.88565185
20Recurrent bronchitis (HP:0002837)2.83287612
21Nemaline bodies (HP:0003798)2.81452284
22Amniotic constriction ring (HP:0009775)2.76647424
23Abnormality of placental membranes (HP:0011409)2.76647424
24Chin dimple (HP:0010751)2.69013748
25IgG deficiency (HP:0004315)2.68478798
26Dry hair (HP:0011359)2.58529886
27Ridged nail (HP:0001807)2.55995589
28Lymphopenia (HP:0001888)2.54365449
29Abnormality of cells of the lymphoid lineage (HP:0012140)2.53273214
30Abnormal auditory evoked potentials (HP:0006958)2.48370387
31Progressive muscle weakness (HP:0003323)2.46547582
32Fetal akinesia sequence (HP:0001989)2.45070152
33Abnormal delivery (HP:0001787)2.43212580
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.40832362
35Aplasia of the musculature (HP:0100854)2.38375989
36Atrophic scars (HP:0001075)2.37477671
37Abnormal gallbladder physiology (HP:0012438)2.26751513
38Cholecystitis (HP:0001082)2.26751513
39Squamous cell carcinoma (HP:0002860)2.26651078
40Fragile skin (HP:0001030)2.24002787
41Hyperacusis (HP:0010780)2.21870384
42Rhabdomyolysis (HP:0003201)2.14904167
43Emphysema (HP:0002097)2.12118060
44Abnormality of T cell physiology (HP:0011840)2.12042704
45Chronic diarrhea (HP:0002028)2.08652138
46Vertebral compression fractures (HP:0002953)2.06403309
47Popliteal pterygium (HP:0009756)2.06099512
48Erythema (HP:0010783)2.05001797
49Muscle fiber inclusion bodies (HP:0100299)2.03886490
50Increased connective tissue (HP:0009025)2.03690373
51Adducted thumb (HP:0001181)2.02335912
52Reduced antithrombin III activity (HP:0001976)2.01866583
53Cellulitis (HP:0100658)2.00467014
54Oral leukoplakia (HP:0002745)1.99605491
55Reduced subcutaneous adipose tissue (HP:0003758)1.99312935
56Meningitis (HP:0001287)1.92593925
57J-shaped sella turcica (HP:0002680)1.92509863
58Entropion (HP:0000621)1.91557020
59Rough bone trabeculation (HP:0100670)1.90719036
60Type I transferrin isoform profile (HP:0003642)1.88801918
61Muscle fiber atrophy (HP:0100295)1.88690842
62Recurrent sinusitis (HP:0011108)1.88492256
63Symphalangism affecting the phalanges of the hand (HP:0009773)1.88167365
64Vasculitis (HP:0002633)1.87285304
65Abnormalities of placenta or umbilical cord (HP:0001194)1.83737521
66Urticaria (HP:0001025)1.80315829
67Ureteral stenosis (HP:0000071)1.79837612
68Glucose intolerance (HP:0000833)1.79594754
69Exercise-induced myalgia (HP:0003738)1.77268083
70Abnormality of incisor morphology (HP:0011063)1.76853068
71Autoimmune hemolytic anemia (HP:0001890)1.76456205
72Elevated erythrocyte sedimentation rate (HP:0003565)1.74306480
73Myoglobinuria (HP:0002913)1.72150152
74Myopathic facies (HP:0002058)1.70914549
75Ureteral obstruction (HP:0006000)1.70474273
76Type 2 muscle fiber atrophy (HP:0003554)1.70071204
77Microvesicular hepatic steatosis (HP:0001414)1.68964673
78Abnormality of the prostate (HP:0008775)1.68436041
79Testicular atrophy (HP:0000029)1.66869079
80Bladder diverticulum (HP:0000015)1.65894163
81Insomnia (HP:0100785)1.65175834
82Lymphoma (HP:0002665)1.64788835
83Aplasia/Hypoplasia involving the musculature (HP:0001460)1.61441230
84Abnormal protein glycosylation (HP:0012346)1.61006423
85Abnormal glycosylation (HP:0012345)1.61006423
86Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61006423
87Abnormal protein N-linked glycosylation (HP:0012347)1.61006423
88Verrucae (HP:0200043)1.59896304
89Papilloma (HP:0012740)1.59896304
90Abnormality of methionine metabolism (HP:0010901)1.59214361
91Restrictive lung disease (HP:0002091)1.58386297
92Skin rash (HP:0000988)1.56849870
93Hepatocellular necrosis (HP:0001404)1.54154586
94Aplastic anemia (HP:0001915)1.53490636
95Increased serum lactate (HP:0002151)1.52565203
96Increased IgM level (HP:0003496)1.52518849
97Basal cell carcinoma (HP:0002671)1.51942584
98Joint contractures involving the joints of the feet (HP:0100492)1.51238165
99Flexion contracture of toe (HP:0005830)1.51238165
100Recurrent pneumonia (HP:0006532)1.49493355

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK14.30430025
2SMG13.94667803
3VRK23.87114566
4TLK13.67353309
5ZAK3.42997596
6NME22.86113018
7BCKDK2.45131848
8EEF2K2.35092325
9TESK22.26027012
10DAPK32.19078233
11TRIB32.07342882
12BUB12.06127872
13CDK122.01830199
14EPHA21.97777306
15BLK1.96612128
16KDR1.94177203
17AURKA1.91395063
18MAPKAPK31.89337237
19SCYL21.81043562
20RPS6KA51.69842775
21IRAK31.67501212
22MAP2K71.63365745
23CDC71.58535635
24TAF11.45791656
25ARAF1.45551037
26PAK41.45218286
27TRPM71.32951312
28MAP4K11.30519900
29RPS6KB21.27589876
30MOS1.21122242
31PKN21.16705617
32NEK11.16073202
33TBK11.09659407
34CDK71.03710965
35PASK1.03313109
36FGFR41.01393308
37DAPK11.00651537
38STK160.99105970
39AURKB0.98606346
40LMTK20.96873465
41EIF2AK30.95070569
42PIK3CG0.94797718
43TESK10.93789006
44CHEK20.92057848
45PIM20.90886048
46STK100.88892382
47MAP3K140.87944985
48MAPKAPK50.87733999
49ICK0.87687567
50ERBB40.86399427
51IRAK40.86071338
52MST1R0.84996250
53NEK90.83735502
54LIMK10.83510124
55MST40.83125858
56NUAK10.82672938
57MAPK110.79329109
58ERN10.77653049
59IKBKB0.76203506
60CDK90.75212826
61CDK190.74800813
62SYK0.74426817
63STK40.71489239
64MAP3K100.71024309
65HIPK20.69249228
66MAP3K130.65700604
67MAP3K80.65507520
68ATR0.63006776
69CSNK1G30.61721605
70CCNB10.61192456
71CDK40.61171937
72AKT20.59217861
73ILK0.59166011
74SRPK10.57020228
75IKBKE0.55984330
76BTK0.53565658
77EIF2AK20.51027520
78CDK80.50055492
79EPHB10.49620167
80CSNK1A1L0.48097792
81CSNK1G10.47319036
82MAP3K90.46697878
83TSSK60.44818838
84CSF1R0.44138543
85CHEK10.42913976
86MUSK0.42656105
87SIK10.42141583
88TXK0.42002038
89BRAF0.41820149
90MAP3K40.38410062
91PAK10.37948798
92PTK60.36790683
93KIT0.35327167
94MAP4K20.34701551
95MAPKAPK20.33077724
96GRK60.32388813
97LYN0.31792593
98JAK30.30516425
99RPS6KA40.27361422
100PBK0.27179514

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053226.62340754
2Alcoholism_Homo sapiens_hsa050343.89849290
3DNA replication_Homo sapiens_hsa030302.97542137
4Primary immunodeficiency_Homo sapiens_hsa053402.80145584
5Allograft rejection_Homo sapiens_hsa053302.73601951
6Proteasome_Homo sapiens_hsa030502.70830260
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.65484409
8Autoimmune thyroid disease_Homo sapiens_hsa053202.56248963
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50445579
10Asthma_Homo sapiens_hsa053102.30751363
11Graft-versus-host disease_Homo sapiens_hsa053322.23187584
12Viral myocarditis_Homo sapiens_hsa054162.12104886
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03094259
14Viral carcinogenesis_Homo sapiens_hsa052031.96189105
15Type I diabetes mellitus_Homo sapiens_hsa049401.91455041
16Pentose phosphate pathway_Homo sapiens_hsa000301.89879953
17Base excision repair_Homo sapiens_hsa034101.87168428
18Antigen processing and presentation_Homo sapiens_hsa046121.82459264
19Mismatch repair_Homo sapiens_hsa034301.66957717
20Biosynthesis of amino acids_Homo sapiens_hsa012301.66684183
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64407927
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63785884
23Nucleotide excision repair_Homo sapiens_hsa034201.46523931
24Ribosome_Homo sapiens_hsa030101.39512996
25Spliceosome_Homo sapiens_hsa030401.37175717
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36743000
27Carbon metabolism_Homo sapiens_hsa012001.35995411
28Pyrimidine metabolism_Homo sapiens_hsa002401.28977640
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25231933
30Non-homologous end-joining_Homo sapiens_hsa034501.23686464
31One carbon pool by folate_Homo sapiens_hsa006701.22080637
32Herpes simplex infection_Homo sapiens_hsa051681.19529416
33Epstein-Barr virus infection_Homo sapiens_hsa051691.14948992
34Sulfur relay system_Homo sapiens_hsa041221.13626774
35RNA transport_Homo sapiens_hsa030131.13125477
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03198372
37Fructose and mannose metabolism_Homo sapiens_hsa000511.00334130
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98944552
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.95351064
40Leishmaniasis_Homo sapiens_hsa051400.89411343
41N-Glycan biosynthesis_Homo sapiens_hsa005100.88169716
42HTLV-I infection_Homo sapiens_hsa051660.87307908
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86062651
44RNA polymerase_Homo sapiens_hsa030200.84974218
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83824777
46B cell receptor signaling pathway_Homo sapiens_hsa046620.81899067
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.78055877
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76339106
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74104780
50Shigellosis_Homo sapiens_hsa051310.73505650
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.72638112
52Homologous recombination_Homo sapiens_hsa034400.72099692
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71458712
54Galactose metabolism_Homo sapiens_hsa000520.67782210
55Measles_Homo sapiens_hsa051620.65598508
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.64978806
57Toxoplasmosis_Homo sapiens_hsa051450.64301917
58Hematopoietic cell lineage_Homo sapiens_hsa046400.63624488
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62105557
60Purine metabolism_Homo sapiens_hsa002300.61455262
61Influenza A_Homo sapiens_hsa051640.61400109
62RNA degradation_Homo sapiens_hsa030180.61342612
63Small cell lung cancer_Homo sapiens_hsa052220.60960636
64Cell cycle_Homo sapiens_hsa041100.56577781
65p53 signaling pathway_Homo sapiens_hsa041150.50041757
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47524409
67Pyruvate metabolism_Homo sapiens_hsa006200.46931416
68Apoptosis_Homo sapiens_hsa042100.46776283
69T cell receptor signaling pathway_Homo sapiens_hsa046600.45539877
70Phenylalanine metabolism_Homo sapiens_hsa003600.41291470
71Selenocompound metabolism_Homo sapiens_hsa004500.38948394
72ECM-receptor interaction_Homo sapiens_hsa045120.36462647
73Protein digestion and absorption_Homo sapiens_hsa049740.35443020
74Focal adhesion_Homo sapiens_hsa045100.33134735
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31795903
76Rheumatoid arthritis_Homo sapiens_hsa053230.28641220
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27767068
78Bladder cancer_Homo sapiens_hsa052190.27422165
79Fanconi anemia pathway_Homo sapiens_hsa034600.25690573
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25431202
81Hepatitis B_Homo sapiens_hsa051610.23846618
82Thyroid cancer_Homo sapiens_hsa052160.21418268
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20802081
84Vitamin B6 metabolism_Homo sapiens_hsa007500.19618398
85Pancreatic cancer_Homo sapiens_hsa052120.18950637
86Sulfur metabolism_Homo sapiens_hsa009200.18400842
87Propanoate metabolism_Homo sapiens_hsa006400.18344268
88Staphylococcus aureus infection_Homo sapiens_hsa051500.18343992
89mRNA surveillance pathway_Homo sapiens_hsa030150.17492256
90Renin-angiotensin system_Homo sapiens_hsa046140.16553069
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16351045
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.12878601
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12566693
94Glutathione metabolism_Homo sapiens_hsa004800.11353968
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10596866
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.10117420
97Basal transcription factors_Homo sapiens_hsa030220.09380793
98Lysine degradation_Homo sapiens_hsa003100.07935646
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.07037215
100Proteoglycans in cancer_Homo sapiens_hsa052050.06910282

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