EEF1A1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.17291686
2cytidine metabolic process (GO:0046087)4.42512102
3cytidine catabolic process (GO:0006216)4.42512102
4cytidine deamination (GO:0009972)4.42512102
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.28457400
6pyrimidine ribonucleoside catabolic process (GO:0046133)3.97438626
7ribosomal small subunit assembly (GO:0000028)3.87742538
8interferon-gamma production (GO:0032609)3.42845141
9positive regulation of prostaglandin secretion (GO:0032308)3.41626093
10tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36157901
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36157901
12cellular response to interleukin-15 (GO:0071350)3.33793998
13positive regulation of T cell mediated cytotoxicity (GO:0001916)3.31817456
14regulation of regulatory T cell differentiation (GO:0045589)3.24333465
15positive regulation of alpha-beta T cell proliferation (GO:0046641)3.17818240
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14014777
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09265702
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07369132
19regulation of T cell mediated cytotoxicity (GO:0001914)3.04871845
20negative T cell selection (GO:0043383)2.98641774
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96816605
22proteasome assembly (GO:0043248)2.95332879
23regulation of cellular amino acid metabolic process (GO:0006521)2.94910014
24positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.92455826
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.92040105
26regulation of B cell receptor signaling pathway (GO:0050855)2.86743069
27positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.82503799
28regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.81733816
29regulation of alpha-beta T cell proliferation (GO:0046640)2.80616370
30actin nucleation (GO:0045010)2.80279178
31negative thymic T cell selection (GO:0045060)2.77488843
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76962099
33water-soluble vitamin biosynthetic process (GO:0042364)2.76576661
34regulation of chronic inflammatory response (GO:0002676)2.75905574
35L-fucose catabolic process (GO:0042355)2.75159974
36fucose catabolic process (GO:0019317)2.75159974
37L-fucose metabolic process (GO:0042354)2.75159974
38positive regulation of defense response to virus by host (GO:0002230)2.74307936
39signal transduction involved in DNA damage checkpoint (GO:0072422)2.73283321
40signal transduction involved in DNA integrity checkpoint (GO:0072401)2.73283321
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.71533569
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.71533569
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.71533569
44signal transduction involved in cell cycle checkpoint (GO:0072395)2.71488162
45regulation of T cell receptor signaling pathway (GO:0050856)2.71149284
46regulation of prostaglandin secretion (GO:0032306)2.70180399
47cullin deneddylation (GO:0010388)2.70131993
48platelet dense granule organization (GO:0060155)2.69139099
49regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67220298
50positive regulation of interleukin-17 production (GO:0032740)2.66730285
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.66657906
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.66657906
53positive thymic T cell selection (GO:0045059)2.66633660
54negative regulation of T cell apoptotic process (GO:0070233)2.65872024
55protein deneddylation (GO:0000338)2.65386570
56response to interleukin-15 (GO:0070672)2.65375016
57mannosylation (GO:0097502)2.65140334
58regulation of isotype switching to IgG isotypes (GO:0048302)2.61089665
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.60316013
60positive regulation of cell killing (GO:0031343)2.60153270
61positive regulation of T cell mediated immunity (GO:0002711)2.59946132
62regulation of gamma-delta T cell differentiation (GO:0045586)2.57697595
63regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.57194689
64replicative senescence (GO:0090399)2.57175420
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.53829538
66positive T cell selection (GO:0043368)2.53688500
67adenosine metabolic process (GO:0046085)2.53558071
68transcription elongation from RNA polymerase III promoter (GO:0006385)2.52639109
69termination of RNA polymerase III transcription (GO:0006386)2.52639109
70metallo-sulfur cluster assembly (GO:0031163)2.52045478
71iron-sulfur cluster assembly (GO:0016226)2.52045478
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.51901805
73rRNA modification (GO:0000154)2.50728977
74preassembly of GPI anchor in ER membrane (GO:0016254)2.50716521
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.47246087
76GPI anchor biosynthetic process (GO:0006506)2.45724719
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45222923
78regulation of cell killing (GO:0031341)2.44893847
79positive regulation of T cell differentiation in thymus (GO:0033089)2.44694076
80pseudouridine synthesis (GO:0001522)2.44456636
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.44349266
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.44349266
83isotype switching (GO:0045190)2.44349266
84rRNA catabolic process (GO:0016075)2.42536652
85mast cell activation (GO:0045576)2.41123399
86positive regulation of T-helper 1 type immune response (GO:0002827)2.40611073
87respiratory chain complex IV assembly (GO:0008535)2.40281646
88ribosome assembly (GO:0042255)2.40083921
89positive regulation of natural killer cell mediated immunity (GO:0002717)2.40077691
90response to interferon-beta (GO:0035456)2.39765476
91ribosomal large subunit biogenesis (GO:0042273)2.39181290
92GPI anchor metabolic process (GO:0006505)2.38334026
93regulation of interleukin-8 secretion (GO:2000482)2.37372156
94T cell receptor signaling pathway (GO:0050852)2.36987658
95positive regulation of interleukin-8 secretion (GO:2000484)2.36957514
96antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.36890628
97regulation of immunoglobulin secretion (GO:0051023)2.36185400
98positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.35033695
99positive regulation of T cell chemotaxis (GO:0010820)2.34417298
100regulation of T cell chemotaxis (GO:0010819)2.34417298

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human3.82433915
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.73105793
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.57671146
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55220501
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.49319079
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.48467385
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.89251419
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84796254
9VDR_23849224_ChIP-Seq_CD4+_Human2.82309979
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.81634310
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75539923
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.64110369
13ZNF274_21170338_ChIP-Seq_K562_Hela2.63685501
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57364783
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50790209
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46521531
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46369475
18ELK1_19687146_ChIP-ChIP_HELA_Human2.37524270
19FOXP3_21729870_ChIP-Seq_TREG_Human2.29326101
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.29211402
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.21180137
22IGF1R_20145208_ChIP-Seq_DFB_Human2.18816101
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.18255452
24VDR_22108803_ChIP-Seq_LS180_Human2.18174552
25MYB_26560356_Chip-Seq_TH2_Human2.15785694
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.06521984
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.03813053
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.03733209
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.78270003
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74846200
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73925931
32IRF1_19129219_ChIP-ChIP_H3396_Human1.71050847
33GATA3_26560356_Chip-Seq_TH2_Human1.69809892
34MYC_18940864_ChIP-ChIP_HL60_Human1.68457615
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66187154
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65191791
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61524408
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56022903
39RUNX_20019798_ChIP-Seq_JUKART_Human1.54706331
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54090107
41GATA1_22025678_ChIP-Seq_K562_Human1.49668265
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.48660208
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46232498
44GATA3_27048872_Chip-Seq_THYMUS_Human1.42375800
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42065462
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39712973
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39133016
48MYB_26560356_Chip-Seq_TH1_Human1.37304205
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35017533
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33473305
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32970498
52TP53_22573176_ChIP-Seq_HFKS_Human1.32794097
53DCP1A_22483619_ChIP-Seq_HELA_Human1.31777739
54AR_20517297_ChIP-Seq_VCAP_Human1.29392322
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28586667
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27299968
57SPI1_23547873_ChIP-Seq_NB4_Human1.27255919
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26024482
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21125320
60EWS_26573619_Chip-Seq_HEK293_Human1.20041186
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.19567295
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18583708
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18027677
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15866120
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15673823
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.15673823
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.13404544
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11194223
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.10544370
70STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09761175
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09354305
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08902735
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05683268
74CIITA_25753668_ChIP-Seq_RAJI_Human1.04762317
75TTF2_22483619_ChIP-Seq_HELA_Human1.04280329
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03931739
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03605308
78FUS_26573619_Chip-Seq_HEK293_Human1.02427845
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01549324
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.01347211
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98583914
82GATA3_26560356_Chip-Seq_TH1_Human0.98061570
83MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97465831
84PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96483494
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95711931
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94321097
87NANOG_19829295_ChIP-Seq_ESCs_Human0.93100144
88SOX2_19829295_ChIP-Seq_ESCs_Human0.93100144
89ER_23166858_ChIP-Seq_MCF-7_Human0.92102104
90GABP_19822575_ChIP-Seq_HepG2_Human0.90665579
91E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88857273
92NANOG_20526341_ChIP-Seq_ESCs_Human0.87779434
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.87650842
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87249479
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86412536
96SALL4_22934838_ChIP-ChIP_CD34+_Human0.86320403
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.85699956
98SMAD_19615063_ChIP-ChIP_OVARY_Human0.85612971
99NCOR_22424771_ChIP-Seq_293T_Human0.85233084
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85143069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.11050528
2MP0001835_abnormal_antigen_presentation3.46250362
3MP0003763_abnormal_thymus_physiology2.92607018
4MP0002166_altered_tumor_susceptibility2.77030827
5MP0009785_altered_susceptibility_to2.74224905
6MP0001800_abnormal_humoral_immune2.49403097
7MP0002138_abnormal_hepatobiliary_system2.43321034
8MP0005000_abnormal_immune_tolerance2.43291047
9MP0002006_tumorigenesis2.42517302
10MP0004147_increased_porphyrin_level2.41728252
11MP0000685_abnormal_immune_system2.36395820
12MP0002148_abnormal_hypersensitivity_rea2.34790921
13MP0009333_abnormal_splenocyte_physiolog2.31868290
14MP0001873_stomach_inflammation2.18378912
15MP0010155_abnormal_intestine_physiology2.08923376
16MP0002723_abnormal_immune_serum2.04070448
17MP0003806_abnormal_nucleotide_metabolis2.03884254
18MP0006072_abnormal_retinal_apoptosis1.99633329
19MP0002102_abnormal_ear_morphology1.96682050
20MP0005075_abnormal_melanosome_morpholog1.94456471
21MP0005360_urolithiasis1.94350077
22MP0002420_abnormal_adaptive_immunity1.93120689
23MP0001790_abnormal_immune_system1.92733377
24MP0005387_immune_system_phenotype1.92733377
25MP0002452_abnormal_antigen_presenting1.91336077
26MP0001819_abnormal_immune_cell1.90440312
27MP0008872_abnormal_physiological_respon1.87831840
28MP0003866_abnormal_defecation1.84720796
29MP0008058_abnormal_DNA_repair1.78483586
30MP0003786_premature_aging1.77826615
31MP0000465_gastrointestinal_hemorrhage1.72864274
32MP0000372_irregular_coat_pigmentation1.71675364
33MP0001986_abnormal_taste_sensitivity1.71300990
34MP0003195_calcinosis1.70086051
35MP0003724_increased_susceptibility_to1.69738083
36MP0003646_muscle_fatigue1.66040748
37MP0009764_decreased_sensitivity_to1.64172126
38MP0002398_abnormal_bone_marrow1.61604186
39MP0005025_abnormal_response_to1.60200938
40MP0003436_decreased_susceptibility_to1.56166151
41MP0001845_abnormal_inflammatory_respons1.54748616
42MP0005084_abnormal_gallbladder_morpholo1.53301086
43MP0000689_abnormal_spleen_morphology1.50947601
44MP0000716_abnormal_immune_system1.49947999
45MP0008875_abnormal_xenobiotic_pharmacok1.49730666
46MP0003252_abnormal_bile_duct1.45751424
47MP0002405_respiratory_system_inflammati1.45054864
48MP0005645_abnormal_hypothalamus_physiol1.43122840
49MP0002722_abnormal_immune_system1.36441367
50MP0008877_abnormal_DNA_methylation1.33888286
51MP0003693_abnormal_embryo_hatching1.33176255
52MP0008995_early_reproductive_senescence1.28306348
53MP0002163_abnormal_gland_morphology1.28176312
54MP0001764_abnormal_homeostasis1.27691698
55MP0002429_abnormal_blood_cell1.27109128
56MP0002933_joint_inflammation1.20029139
57MP0000703_abnormal_thymus_morphology1.19960598
58MP0006036_abnormal_mitochondrial_physio1.19404374
59MP0003718_maternal_effect1.18459794
60MP0008469_abnormal_protein_level1.18197061
61MP0002876_abnormal_thyroid_physiology1.17494963
62MP0001661_extended_life_span1.14931955
63MP0002419_abnormal_innate_immunity1.13058579
64MP0002396_abnormal_hematopoietic_system1.02894426
65MP0005389_reproductive_system_phenotype1.02590676
66MP0001919_abnormal_reproductive_system1.01084936
67MP0002009_preneoplasia1.00453989
68MP0005085_abnormal_gallbladder_physiolo1.00240825
69MP0000013_abnormal_adipose_tissue0.99713228
70MP0005253_abnormal_eye_physiology0.99281789
71MP0009697_abnormal_copulation0.98872486
72MP0009643_abnormal_urine_homeostasis0.97267175
73MP0005410_abnormal_fertilization0.95272563
74MP0003950_abnormal_plasma_membrane0.91830442
75MP0005166_decreased_susceptibility_to0.91584625
76MP0002019_abnormal_tumor_incidence0.90104514
77MP0006082_CNS_inflammation0.89420908
78MP0000490_abnormal_crypts_of0.86917901
79MP0003011_delayed_dark_adaptation0.85140592
80MP0005332_abnormal_amino_acid0.84540886
81MP0003186_abnormal_redox_activity0.84066717
82MP0002136_abnormal_kidney_physiology0.83913124
83MP0002254_reproductive_system_inflammat0.82904911
84MP0005636_abnormal_mineral_homeostasis0.82060019
85MP0004043_abnormal_pH_regulation0.79038770
86MP0005551_abnormal_eye_electrophysiolog0.78842393
87MP0005464_abnormal_platelet_physiology0.78760784
88MP0002693_abnormal_pancreas_physiology0.77377461
89MP0001765_abnormal_ion_homeostasis0.76623305
90MP0005365_abnormal_bile_salt0.75012133
91MP0006035_abnormal_mitochondrial_morpho0.73839094
92MP0001533_abnormal_skeleton_physiology0.73566771
93MP0005310_abnormal_salivary_gland0.71594399
94MP0001119_abnormal_female_reproductive0.71001803
95MP0010094_abnormal_chromosome_stability0.69202340
96MP0001666_abnormal_nutrient_absorption0.68990180
97MP0005319_abnormal_enzyme/_coenzyme0.68667451
98MP0008007_abnormal_cellular_replicative0.66323658
99MP0002837_dystrophic_cardiac_calcinosis0.66075973
100MP0004947_skin_inflammation0.64141743

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.12851761
2Abnormality of B cell number (HP:0010975)3.91838761
3Oral leukoplakia (HP:0002745)3.89061475
4Severe combined immunodeficiency (HP:0004430)3.60320655
5Abnormality of T cell number (HP:0011839)3.52739170
6Chronic diarrhea (HP:0002028)3.42164126
7T lymphocytopenia (HP:0005403)3.28589440
8Stomatitis (HP:0010280)3.26272056
9B lymphocytopenia (HP:0010976)3.21380026
10Autoimmune hemolytic anemia (HP:0001890)3.21198121
11Abnormality of the prostate (HP:0008775)3.18813339
12Thyroiditis (HP:0100646)3.13041651
13Tongue fasciculations (HP:0001308)3.11440459
14Renal cortical cysts (HP:0000803)3.10957389
15Abnormality of T cells (HP:0002843)3.10921323
16Increased hepatocellular lipid droplets (HP:0006565)3.09759019
17Hypoproteinemia (HP:0003075)3.09652618
18Stomach cancer (HP:0012126)3.02180316
19Lipid accumulation in hepatocytes (HP:0006561)3.01883152
20Congenital stationary night blindness (HP:0007642)3.00705744
21Elevated erythrocyte sedimentation rate (HP:0003565)2.99626842
22Hepatocellular necrosis (HP:0001404)2.98508445
23Mitochondrial inheritance (HP:0001427)2.94459174
24Abnormality of T cell physiology (HP:0011840)2.86550256
25Hepatic necrosis (HP:0002605)2.84801582
26Increased CSF lactate (HP:0002490)2.82391927
27Increased IgM level (HP:0003496)2.72850877
28Combined immunodeficiency (HP:0005387)2.69668402
29Abnormality of eosinophils (HP:0001879)2.68185797
30Aplastic anemia (HP:0001915)2.67124896
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.64442272
32Muscle fibrillation (HP:0010546)2.59631590
33Abnormality of the renal cortex (HP:0011035)2.55691320
34Increased intramyocellular lipid droplets (HP:0012240)2.50070519
35Increased serum lactate (HP:0002151)2.49665248
36Abolished electroretinogram (ERG) (HP:0000550)2.48265673
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47343336
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46332694
39Pancreatic cysts (HP:0001737)2.46124009
40Prostate neoplasm (HP:0100787)2.43955675
41Agammaglobulinemia (HP:0004432)2.43551346
42Decreased circulating renin level (HP:0003351)2.40870686
43Panhypogammaglobulinemia (HP:0003139)2.35192185
44Renal Fanconi syndrome (HP:0001994)2.34411773
45Hypoplasia of the uterus (HP:0000013)2.30675376
46Autoimmune thrombocytopenia (HP:0001973)2.28240668
47Methylmalonic acidemia (HP:0002912)2.27315018
48Attenuation of retinal blood vessels (HP:0007843)2.26916127
49Eosinophilia (HP:0001880)2.25927668
50Acute necrotizing encephalopathy (HP:0006965)2.25617828
51Aplasia/hypoplasia of the uterus (HP:0008684)2.23856533
52Polydipsia (HP:0001959)2.23538212
53Abnormal drinking behavior (HP:0030082)2.23538212
54Abnormality of urine glucose concentration (HP:0011016)2.23240582
55Glycosuria (HP:0003076)2.23240582
563-Methylglutaconic aciduria (HP:0003535)2.21947652
57Dicarboxylic aciduria (HP:0003215)2.14692920
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14692920
59Acute encephalopathy (HP:0006846)2.14340152
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13054985
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12643858
62Type I transferrin isoform profile (HP:0003642)2.12589417
63Increased muscle lipid content (HP:0009058)2.11962817
64Pancytopenia (HP:0001876)2.10657339
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10398938
66IgM deficiency (HP:0002850)2.09603328
67Type 2 muscle fiber atrophy (HP:0003554)2.07754321
68Pustule (HP:0200039)2.05876821
69Lactic acidosis (HP:0003128)2.05618413
70Exertional dyspnea (HP:0002875)2.03660247
71True hermaphroditism (HP:0010459)2.02864309
72Progressive macrocephaly (HP:0004481)2.02321337
73Abnormal rod and cone electroretinograms (HP:0008323)2.01371464
74Generalized aminoaciduria (HP:0002909)1.99398480
75Abnormal mitochondria in muscle tissue (HP:0008316)1.97063673
76Lymphoma (HP:0002665)1.96964595
77Abnormality of the vitamin B12 metabolism (HP:0004341)1.96921896
78Abnormal protein glycosylation (HP:0012346)1.96785645
79Abnormal glycosylation (HP:0012345)1.96785645
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96785645
81Abnormal protein N-linked glycosylation (HP:0012347)1.96785645
82Recurrent bronchitis (HP:0002837)1.96586188
83Constricted visual fields (HP:0001133)1.92568935
84Abnormality of male internal genitalia (HP:0000022)1.92374048
85Congenital, generalized hypertrichosis (HP:0004540)1.90676727
86Lethargy (HP:0001254)1.89678540
87Granulocytopenia (HP:0001913)1.89490867
88Abnormality of vitamin B metabolism (HP:0004340)1.88562411
89Encephalitis (HP:0002383)1.88470690
90Methylmalonic aciduria (HP:0012120)1.86727650
91Abnormality of the pons (HP:0007361)1.85199838
92Dyschromatopsia (HP:0007641)1.84456951
93Neutropenia (HP:0001875)1.82282594
94Pancreatic fibrosis (HP:0100732)1.81665783
95Optic disc pallor (HP:0000543)1.80453032
96Vasculitis (HP:0002633)1.79564722
97Hyperalaninemia (HP:0003348)1.78854870
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78854870
99Abnormality of alanine metabolism (HP:0010916)1.78854870
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78638692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.08116639
2ZAK3.80518864
3TLK13.15324963
4TAOK32.92893870
5MAP4K22.71153583
6KDR2.45670985
7NUAK12.42677386
8BLK2.41516010
9EIF2AK32.40586937
10TESK22.21397058
11MST42.13289907
12VRK22.08201795
13MAP4K12.03721689
14VRK11.88776031
15ADRBK21.85576353
16BCKDK1.80286085
17PASK1.77220600
18FRK1.73939303
19KIT1.68177058
20GRK11.64983265
21STK161.58807641
22SCYL21.58681019
23MAP3K141.53453586
24BMPR21.53133143
25GRK61.50360715
26TEC1.49609075
27ITK1.47437828
28CDK191.46360574
29IKBKB1.43271430
30SYK1.40090574
31MAP3K121.31234202
32IKBKE1.29525350
33ERBB31.27568000
34BMPR1B1.24462954
35FES1.23979800
36TRIM281.19917763
37CSF1R1.02946562
38TIE10.99837623
39TRPM70.95992217
40WNK40.94203528
41JAK30.93467088
42MAP3K40.93119867
43MYLK0.92711974
44TBK10.91390163
45FLT30.90046781
46LYN0.87960608
47TSSK60.87657644
48PIK3CG0.87547797
49ACVR1B0.87138811
50BUB10.85665677
51LCK0.85416026
52STK390.84946142
53PRKCQ0.82092459
54DAPK10.81089467
55MAPKAPK30.79311324
56MAP2K70.78641630
57OXSR10.78331313
58CDK80.75783156
59EIF2AK20.73971604
60RPS6KA50.72904655
61BTK0.72249232
62MATK0.72123517
63NEK10.71767309
64PLK40.71620264
65TGFBR10.70256071
66INSRR0.66739314
67CSNK1G10.66015798
68PLK30.64482529
69PIM10.63370958
70BRSK20.63011486
71CSNK1G30.58952632
72PBK0.58078837
73IGF1R0.58058496
74NME10.56882741
75MKNK10.56819632
76RPS6KA40.55637112
77WNK30.55214961
78BCR0.54739659
79SRPK10.52862839
80MAP2K20.49674937
81PINK10.48713690
82GRK70.48116836
83ZAP700.47243456
84EIF2AK10.45923427
85MAP2K60.43338809
86HCK0.42846179
87NLK0.42334218
88MUSK0.39655144
89DAPK30.37687326
90ATR0.34796383
91PRKCE0.33021848
92ADRBK10.32928361
93TAF10.31705335
94RPS6KB20.31404042
95ILK0.30813841
96CSNK2A10.30758431
97CSNK1A1L0.30399811
98CSK0.29778418
99PDK20.28264102
100CDK40.26244915

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.65087822
2Primary immunodeficiency_Homo sapiens_hsa053403.54877487
3Allograft rejection_Homo sapiens_hsa053303.23331717
4Autoimmune thyroid disease_Homo sapiens_hsa053203.03934022
5Asthma_Homo sapiens_hsa053103.01912330
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.01365028
7Graft-versus-host disease_Homo sapiens_hsa053322.99882459
8Type I diabetes mellitus_Homo sapiens_hsa049402.70310556
9Antigen processing and presentation_Homo sapiens_hsa046122.25802026
10RNA polymerase_Homo sapiens_hsa030202.14675867
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11011254
12Protein export_Homo sapiens_hsa030602.05517637
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02212067
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01693510
15Ribosome_Homo sapiens_hsa030101.93504911
16Hematopoietic cell lineage_Homo sapiens_hsa046401.83907252
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72325373
18Oxidative phosphorylation_Homo sapiens_hsa001901.67612109
19Sulfur metabolism_Homo sapiens_hsa009201.65402561
20Rheumatoid arthritis_Homo sapiens_hsa053231.56310445
21Caffeine metabolism_Homo sapiens_hsa002321.55494445
22One carbon pool by folate_Homo sapiens_hsa006701.44647003
23RNA degradation_Homo sapiens_hsa030181.43309352
24Homologous recombination_Homo sapiens_hsa034401.39405045
25Parkinsons disease_Homo sapiens_hsa050121.30504062
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.30374770
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28886019
28Systemic lupus erythematosus_Homo sapiens_hsa053221.26668224
29Linoleic acid metabolism_Homo sapiens_hsa005911.26432097
30Non-homologous end-joining_Homo sapiens_hsa034501.20433601
31Viral myocarditis_Homo sapiens_hsa054161.20002198
32Basal transcription factors_Homo sapiens_hsa030221.19370747
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16558829
34Pyrimidine metabolism_Homo sapiens_hsa002401.14880727
35Selenocompound metabolism_Homo sapiens_hsa004501.13190008
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09985586
37T cell receptor signaling pathway_Homo sapiens_hsa046601.08344660
38Purine metabolism_Homo sapiens_hsa002301.08022327
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05254324
40RNA transport_Homo sapiens_hsa030131.03862037
41Phototransduction_Homo sapiens_hsa047441.03328964
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01229303
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.00879291
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00262313
45Arachidonic acid metabolism_Homo sapiens_hsa005900.98665112
46Leishmaniasis_Homo sapiens_hsa051400.96691680
47Fanconi anemia pathway_Homo sapiens_hsa034600.95904965
48Herpes simplex infection_Homo sapiens_hsa051680.95372907
49Nucleotide excision repair_Homo sapiens_hsa034200.95202547
50Peroxisome_Homo sapiens_hsa041460.93302444
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93120728
52Fat digestion and absorption_Homo sapiens_hsa049750.91443479
53Mismatch repair_Homo sapiens_hsa034300.88324666
54Propanoate metabolism_Homo sapiens_hsa006400.87948671
55Spliceosome_Homo sapiens_hsa030400.87735703
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87675342
57Butanoate metabolism_Homo sapiens_hsa006500.82782549
58Tryptophan metabolism_Homo sapiens_hsa003800.81209863
59Measles_Homo sapiens_hsa051620.79108511
60Staphylococcus aureus infection_Homo sapiens_hsa051500.78042503
61DNA replication_Homo sapiens_hsa030300.75412843
62Base excision repair_Homo sapiens_hsa034100.74745812
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73128855
64Legionellosis_Homo sapiens_hsa051340.70694493
65Chemical carcinogenesis_Homo sapiens_hsa052040.69867905
66Glutathione metabolism_Homo sapiens_hsa004800.69776120
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69536079
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62196138
69Ether lipid metabolism_Homo sapiens_hsa005650.61963926
70Fatty acid elongation_Homo sapiens_hsa000620.60507913
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.60418160
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60332555
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.60021007
74Retinol metabolism_Homo sapiens_hsa008300.60007804
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.59670649
76Huntingtons disease_Homo sapiens_hsa050160.59037950
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58556150
78Alzheimers disease_Homo sapiens_hsa050100.55875438
79Vitamin digestion and absorption_Homo sapiens_hsa049770.55743099
80Nitrogen metabolism_Homo sapiens_hsa009100.55605528
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53297609
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53222431
83Regulation of autophagy_Homo sapiens_hsa041400.53085298
84Epstein-Barr virus infection_Homo sapiens_hsa051690.50645700
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49586522
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47754058
87TNF signaling pathway_Homo sapiens_hsa046680.47381403
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47331954
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46991884
90Metabolic pathways_Homo sapiens_hsa011000.43367298
91Shigellosis_Homo sapiens_hsa051310.42928949
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.38091975
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35810841
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35777958
95N-Glycan biosynthesis_Homo sapiens_hsa005100.34427037
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.33996482
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33301614
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31064206
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29607940
100Olfactory transduction_Homo sapiens_hsa047400.25332825

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