ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.17291686
2	cytidine metabolic process (GO:0046087)	4.42512102
3	cytidine catabolic process (GO:0006216)	4.42512102
4	cytidine deamination (GO:0009972)	4.42512102
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.28457400
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.97438626
7	ribosomal small subunit assembly (GO:0000028)	3.87742538
8	interferon-gamma production (GO:0032609)	3.42845141
9	positive regulation of prostaglandin secretion (GO:0032308)	3.41626093
10	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.36157901
11	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.36157901
12	cellular response to interleukin-15 (GO:0071350)	3.33793998
13	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.31817456
14	regulation of regulatory T cell differentiation (GO:0045589)	3.24333465
15	positive regulation of alpha-beta T cell proliferation (GO:0046641)	3.17818240
16	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.14014777
17	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.09265702
18	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.07369132
19	regulation of T cell mediated cytotoxicity (GO:0001914)	3.04871845
20	negative T cell selection (GO:0043383)	2.98641774
21	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.96816605
22	proteasome assembly (GO:0043248)	2.95332879
23	regulation of cellular amino acid metabolic process (GO:0006521)	2.94910014
24	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.92455826
25	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.92040105
26	regulation of B cell receptor signaling pathway (GO:0050855)	2.86743069
27	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.82503799
28	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.81733816
29	regulation of alpha-beta T cell proliferation (GO:0046640)	2.80616370
30	actin nucleation (GO:0045010)	2.80279178
31	negative thymic T cell selection (GO:0045060)	2.77488843
32	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.76962099
33	water-soluble vitamin biosynthetic process (GO:0042364)	2.76576661
34	regulation of chronic inflammatory response (GO:0002676)	2.75905574
35	L-fucose catabolic process (GO:0042355)	2.75159974
36	fucose catabolic process (GO:0019317)	2.75159974
37	L-fucose metabolic process (GO:0042354)	2.75159974
38	positive regulation of defense response to virus by host (GO:0002230)	2.74307936
39	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.73283321
40	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.73283321
41	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.71533569
42	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.71533569
43	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.71533569
44	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.71488162
45	regulation of T cell receptor signaling pathway (GO:0050856)	2.71149284
46	regulation of prostaglandin secretion (GO:0032306)	2.70180399
47	cullin deneddylation (GO:0010388)	2.70131993
48	platelet dense granule organization (GO:0060155)	2.69139099
49	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.67220298
50	positive regulation of interleukin-17 production (GO:0032740)	2.66730285
51	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.66657906
52	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.66657906
53	positive thymic T cell selection (GO:0045059)	2.66633660
54	negative regulation of T cell apoptotic process (GO:0070233)	2.65872024
55	protein deneddylation (GO:0000338)	2.65386570
56	response to interleukin-15 (GO:0070672)	2.65375016
57	mannosylation (GO:0097502)	2.65140334
58	regulation of isotype switching to IgG isotypes (GO:0048302)	2.61089665
59	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.60316013
60	positive regulation of cell killing (GO:0031343)	2.60153270
61	positive regulation of T cell mediated immunity (GO:0002711)	2.59946132
62	regulation of gamma-delta T cell differentiation (GO:0045586)	2.57697595
63	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.57194689
64	replicative senescence (GO:0090399)	2.57175420
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.53829538
66	positive T cell selection (GO:0043368)	2.53688500
67	adenosine metabolic process (GO:0046085)	2.53558071
68	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.52639109
69	termination of RNA polymerase III transcription (GO:0006386)	2.52639109
70	iron-sulfur cluster assembly (GO:0016226)	2.52045478
71	metallo-sulfur cluster assembly (GO:0031163)	2.52045478
72	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.51901805
73	rRNA modification (GO:0000154)	2.50728977
74	preassembly of GPI anchor in ER membrane (GO:0016254)	2.50716521
75	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.47246087
76	GPI anchor biosynthetic process (GO:0006506)	2.45724719
77	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.45222923
78	regulation of cell killing (GO:0031341)	2.44893847
79	positive regulation of T cell differentiation in thymus (GO:0033089)	2.44694076
80	pseudouridine synthesis (GO:0001522)	2.44456636
81	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.44349266
82	isotype switching (GO:0045190)	2.44349266
83	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.44349266
84	rRNA catabolic process (GO:0016075)	2.42536652
85	mast cell activation (GO:0045576)	2.41123399
86	positive regulation of T-helper 1 type immune response (GO:0002827)	2.40611073
87	respiratory chain complex IV assembly (GO:0008535)	2.40281646
88	ribosome assembly (GO:0042255)	2.40083921
89	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.40077691
90	response to interferon-beta (GO:0035456)	2.39765476
91	ribosomal large subunit biogenesis (GO:0042273)	2.39181290
92	GPI anchor metabolic process (GO:0006505)	2.38334026
93	regulation of interleukin-8 secretion (GO:2000482)	2.37372156
94	T cell receptor signaling pathway (GO:0050852)	2.36987658
95	positive regulation of interleukin-8 secretion (GO:2000484)	2.36957514
96	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.36890628
97	regulation of immunoglobulin secretion (GO:0051023)	2.36185400
98	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.35033695
99	positive regulation of T cell chemotaxis (GO:0010820)	2.34417298
100	regulation of T cell chemotaxis (GO:0010819)	2.34417298

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.82433915
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.73105793
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.57671146
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55220501
5	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.49319079
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.48467385
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.89251419
8	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.84796254
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.82309979
10	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.81634310
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.75539923
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.64110369
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.63685501
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.57364783
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.50790209
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.46521531
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.46369475
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.37524270
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.29326101
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.29211402
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21180137
22	IGF1R_20145208_ChIP-Seq_DFB_Human	2.18816101
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.18255452
24	VDR_22108803_ChIP-Seq_LS180_Human	2.18174552
25	MYB_26560356_Chip-Seq_TH2_Human	2.15785694
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.06521984
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03813053
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.03733209
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.78270003
30	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.74846200
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73925931
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71050847
33	GATA3_26560356_Chip-Seq_TH2_Human	1.69809892
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.68457615
35	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.66187154
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.65191791
37	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.61524408
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56022903
39	RUNX_20019798_ChIP-Seq_JUKART_Human	1.54706331
40	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.54090107
41	GATA1_22025678_ChIP-Seq_K562_Human	1.49668265
42	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.48660208
43	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.46232498
44	GATA3_27048872_Chip-Seq_THYMUS_Human	1.42375800
45	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.42065462
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.39712973
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.39133016
48	MYB_26560356_Chip-Seq_TH1_Human	1.37304205
49	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.35017533
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33473305
51	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.32970498
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.32794097
53	DCP1A_22483619_ChIP-Seq_HELA_Human	1.31777739
54	AR_20517297_ChIP-Seq_VCAP_Human	1.29392322
55	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28586667
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.27299968
57	SPI1_23547873_ChIP-Seq_NB4_Human	1.27255919
58	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26024482
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21125320
60	EWS_26573619_Chip-Seq_HEK293_Human	1.20041186
61	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.19567295
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.18583708
63	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.18027677
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15866120
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.15673823
66	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.15673823
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13404544
68	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.11194223
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10544370
70	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.09761175
71	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09354305
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.08902735
73	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.05683268
74	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04762317
75	TTF2_22483619_ChIP-Seq_HELA_Human	1.04280329
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03931739
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03605308
78	FUS_26573619_Chip-Seq_HEK293_Human	1.02427845
79	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01549324
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01347211
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98583914
82	GATA3_26560356_Chip-Seq_TH1_Human	0.98061570
83	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97465831
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96483494
85	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.95711931
86	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.94321097
87	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93100144
88	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93100144
89	ER_23166858_ChIP-Seq_MCF-7_Human	0.92102104
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.90665579
91	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.88857273
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87779434
93	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87650842
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87249479
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.86412536
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.86320403
97	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.85699956
98	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.85612971
99	NCOR_22424771_ChIP-Seq_293T_Human	0.85233084
100	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85143069

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.11050528
2	MP0001835_abnormal_antigen_presentation	3.46250362
3	MP0003763_abnormal_thymus_physiology	2.92607018
4	MP0002166_altered_tumor_susceptibility	2.77030827
5	MP0009785_altered_susceptibility_to	2.74224905
6	MP0001800_abnormal_humoral_immune	2.49403097
7	MP0002138_abnormal_hepatobiliary_system	2.43321034
8	MP0005000_abnormal_immune_tolerance	2.43291047
9	MP0002006_tumorigenesis	2.42517302
10	MP0004147_increased_porphyrin_level	2.41728252
11	MP0000685_abnormal_immune_system	2.36395820
12	MP0002148_abnormal_hypersensitivity_rea	2.34790921
13	MP0009333_abnormal_splenocyte_physiolog	2.31868290
14	MP0001873_stomach_inflammation	2.18378912
15	MP0010155_abnormal_intestine_physiology	2.08923376
16	MP0002723_abnormal_immune_serum	2.04070448
17	MP0003806_abnormal_nucleotide_metabolis	2.03884254
18	MP0006072_abnormal_retinal_apoptosis	1.99633329
19	MP0002102_abnormal_ear_morphology	1.96682050
20	MP0005075_abnormal_melanosome_morpholog	1.94456471
21	MP0005360_urolithiasis	1.94350077
22	MP0002420_abnormal_adaptive_immunity	1.93120689
23	MP0005387_immune_system_phenotype	1.92733377
24	MP0001790_abnormal_immune_system	1.92733377
25	MP0002452_abnormal_antigen_presenting	1.91336077
26	MP0001819_abnormal_immune_cell	1.90440312
27	MP0008872_abnormal_physiological_respon	1.87831840
28	MP0003866_abnormal_defecation	1.84720796
29	MP0008058_abnormal_DNA_repair	1.78483586
30	MP0003786_premature_aging	1.77826615
31	MP0000465_gastrointestinal_hemorrhage	1.72864274
32	MP0000372_irregular_coat_pigmentation	1.71675364
33	MP0001986_abnormal_taste_sensitivity	1.71300990
34	MP0003195_calcinosis	1.70086051
35	MP0003724_increased_susceptibility_to	1.69738083
36	MP0003646_muscle_fatigue	1.66040748
37	MP0009764_decreased_sensitivity_to	1.64172126
38	MP0002398_abnormal_bone_marrow	1.61604186
39	MP0005025_abnormal_response_to	1.60200938
40	MP0003436_decreased_susceptibility_to	1.56166151
41	MP0001845_abnormal_inflammatory_respons	1.54748616
42	MP0005084_abnormal_gallbladder_morpholo	1.53301086
43	MP0000689_abnormal_spleen_morphology	1.50947601
44	MP0000716_abnormal_immune_system	1.49947999
45	MP0008875_abnormal_xenobiotic_pharmacok	1.49730666
46	MP0003252_abnormal_bile_duct	1.45751424
47	MP0002405_respiratory_system_inflammati	1.45054864
48	MP0005645_abnormal_hypothalamus_physiol	1.43122840
49	MP0002722_abnormal_immune_system	1.36441367
50	MP0008877_abnormal_DNA_methylation	1.33888286
51	MP0003693_abnormal_embryo_hatching	1.33176255
52	MP0008995_early_reproductive_senescence	1.28306348
53	MP0002163_abnormal_gland_morphology	1.28176312
54	MP0001764_abnormal_homeostasis	1.27691698
55	MP0002429_abnormal_blood_cell	1.27109128
56	MP0002933_joint_inflammation	1.20029139
57	MP0000703_abnormal_thymus_morphology	1.19960598
58	MP0006036_abnormal_mitochondrial_physio	1.19404374
59	MP0003718_maternal_effect	1.18459794
60	MP0008469_abnormal_protein_level	1.18197061
61	MP0002876_abnormal_thyroid_physiology	1.17494963
62	MP0001661_extended_life_span	1.14931955
63	MP0002419_abnormal_innate_immunity	1.13058579
64	MP0002396_abnormal_hematopoietic_system	1.02894426
65	MP0005389_reproductive_system_phenotype	1.02590676
66	MP0001919_abnormal_reproductive_system	1.01084936
67	MP0002009_preneoplasia	1.00453989
68	MP0005085_abnormal_gallbladder_physiolo	1.00240825
69	MP0000013_abnormal_adipose_tissue	0.99713228
70	MP0005253_abnormal_eye_physiology	0.99281789
71	MP0009697_abnormal_copulation	0.98872486
72	MP0009643_abnormal_urine_homeostasis	0.97267175
73	MP0005410_abnormal_fertilization	0.95272563
74	MP0003950_abnormal_plasma_membrane	0.91830442
75	MP0005166_decreased_susceptibility_to	0.91584625
76	MP0002019_abnormal_tumor_incidence	0.90104514
77	MP0006082_CNS_inflammation	0.89420908
78	MP0000490_abnormal_crypts_of	0.86917901
79	MP0003011_delayed_dark_adaptation	0.85140592
80	MP0005332_abnormal_amino_acid	0.84540886
81	MP0003186_abnormal_redox_activity	0.84066717
82	MP0002136_abnormal_kidney_physiology	0.83913124
83	MP0002254_reproductive_system_inflammat	0.82904911
84	MP0005636_abnormal_mineral_homeostasis	0.82060019
85	MP0004043_abnormal_pH_regulation	0.79038770
86	MP0005551_abnormal_eye_electrophysiolog	0.78842393
87	MP0005464_abnormal_platelet_physiology	0.78760784
88	MP0002693_abnormal_pancreas_physiology	0.77377461
89	MP0001765_abnormal_ion_homeostasis	0.76623305
90	MP0005365_abnormal_bile_salt	0.75012133
91	MP0006035_abnormal_mitochondrial_morpho	0.73839094
92	MP0001533_abnormal_skeleton_physiology	0.73566771
93	MP0005310_abnormal_salivary_gland	0.71594399
94	MP0001119_abnormal_female_reproductive	0.71001803
95	MP0010094_abnormal_chromosome_stability	0.69202340
96	MP0001666_abnormal_nutrient_absorption	0.68990180
97	MP0005319_abnormal_enzyme/_coenzyme	0.68667451
98	MP0008007_abnormal_cellular_replicative	0.66323658
99	MP0002837_dystrophic_cardiac_calcinosis	0.66075973
100	MP0004947_skin_inflammation	0.64141743

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.12851761
2	Abnormality of B cell number (HP:0010975)	3.91838761
3	Oral leukoplakia (HP:0002745)	3.89061475
4	Severe combined immunodeficiency (HP:0004430)	3.60320655
5	Abnormality of T cell number (HP:0011839)	3.52739170
6	Chronic diarrhea (HP:0002028)	3.42164126
7	T lymphocytopenia (HP:0005403)	3.28589440
8	Stomatitis (HP:0010280)	3.26272056
9	B lymphocytopenia (HP:0010976)	3.21380026
10	Autoimmune hemolytic anemia (HP:0001890)	3.21198121
11	Abnormality of the prostate (HP:0008775)	3.18813339
12	Thyroiditis (HP:0100646)	3.13041651
13	Tongue fasciculations (HP:0001308)	3.11440459
14	Renal cortical cysts (HP:0000803)	3.10957389
15	Abnormality of T cells (HP:0002843)	3.10921323
16	Increased hepatocellular lipid droplets (HP:0006565)	3.09759019
17	Hypoproteinemia (HP:0003075)	3.09652618
18	Stomach cancer (HP:0012126)	3.02180316
19	Lipid accumulation in hepatocytes (HP:0006561)	3.01883152
20	Congenital stationary night blindness (HP:0007642)	3.00705744
21	Elevated erythrocyte sedimentation rate (HP:0003565)	2.99626842
22	Hepatocellular necrosis (HP:0001404)	2.98508445
23	Mitochondrial inheritance (HP:0001427)	2.94459174
24	Abnormality of T cell physiology (HP:0011840)	2.86550256
25	Hepatic necrosis (HP:0002605)	2.84801582
26	Increased CSF lactate (HP:0002490)	2.82391927
27	Increased IgM level (HP:0003496)	2.72850877
28	Combined immunodeficiency (HP:0005387)	2.69668402
29	Abnormality of eosinophils (HP:0001879)	2.68185797
30	Aplastic anemia (HP:0001915)	2.67124896
31	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.64442272
32	Muscle fibrillation (HP:0010546)	2.59631590
33	Abnormality of the renal cortex (HP:0011035)	2.55691320
34	Increased intramyocellular lipid droplets (HP:0012240)	2.50070519
35	Increased serum lactate (HP:0002151)	2.49665248
36	Abolished electroretinogram (ERG) (HP:0000550)	2.48265673
37	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.47343336
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.46332694
39	Pancreatic cysts (HP:0001737)	2.46124009
40	Prostate neoplasm (HP:0100787)	2.43955675
41	Agammaglobulinemia (HP:0004432)	2.43551346
42	Decreased circulating renin level (HP:0003351)	2.40870686
43	Panhypogammaglobulinemia (HP:0003139)	2.35192185
44	Renal Fanconi syndrome (HP:0001994)	2.34411773
45	Hypoplasia of the uterus (HP:0000013)	2.30675376
46	Autoimmune thrombocytopenia (HP:0001973)	2.28240668
47	Methylmalonic acidemia (HP:0002912)	2.27315018
48	Attenuation of retinal blood vessels (HP:0007843)	2.26916127
49	Eosinophilia (HP:0001880)	2.25927668
50	Acute necrotizing encephalopathy (HP:0006965)	2.25617828
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.23856533
52	Abnormal drinking behavior (HP:0030082)	2.23538212
53	Polydipsia (HP:0001959)	2.23538212
54	Glycosuria (HP:0003076)	2.23240582
55	Abnormality of urine glucose concentration (HP:0011016)	2.23240582
56	3-Methylglutaconic aciduria (HP:0003535)	2.21947652
57	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.14692920
58	Dicarboxylic aciduria (HP:0003215)	2.14692920
59	Acute encephalopathy (HP:0006846)	2.14340152
60	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13054985
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12643858
62	Type I transferrin isoform profile (HP:0003642)	2.12589417
63	Increased muscle lipid content (HP:0009058)	2.11962817
64	Pancytopenia (HP:0001876)	2.10657339
65	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.10398938
66	IgM deficiency (HP:0002850)	2.09603328
67	Type 2 muscle fiber atrophy (HP:0003554)	2.07754321
68	Pustule (HP:0200039)	2.05876821
69	Lactic acidosis (HP:0003128)	2.05618413
70	Exertional dyspnea (HP:0002875)	2.03660247
71	True hermaphroditism (HP:0010459)	2.02864309
72	Progressive macrocephaly (HP:0004481)	2.02321337
73	Abnormal rod and cone electroretinograms (HP:0008323)	2.01371464
74	Generalized aminoaciduria (HP:0002909)	1.99398480
75	Abnormal mitochondria in muscle tissue (HP:0008316)	1.97063673
76	Lymphoma (HP:0002665)	1.96964595
77	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.96921896
78	Abnormal protein glycosylation (HP:0012346)	1.96785645
79	Abnormal glycosylation (HP:0012345)	1.96785645
80	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.96785645
81	Abnormal protein N-linked glycosylation (HP:0012347)	1.96785645
82	Recurrent bronchitis (HP:0002837)	1.96586188
83	Constricted visual fields (HP:0001133)	1.92568935
84	Abnormality of male internal genitalia (HP:0000022)	1.92374048
85	Congenital, generalized hypertrichosis (HP:0004540)	1.90676727
86	Lethargy (HP:0001254)	1.89678540
87	Granulocytopenia (HP:0001913)	1.89490867
88	Abnormality of vitamin B metabolism (HP:0004340)	1.88562411
89	Encephalitis (HP:0002383)	1.88470690
90	Methylmalonic aciduria (HP:0012120)	1.86727650
91	Abnormality of the pons (HP:0007361)	1.85199838
92	Dyschromatopsia (HP:0007641)	1.84456951
93	Neutropenia (HP:0001875)	1.82282594
94	Pancreatic fibrosis (HP:0100732)	1.81665783
95	Optic disc pallor (HP:0000543)	1.80453032
96	Vasculitis (HP:0002633)	1.79564722
97	Abnormality of alanine metabolism (HP:0010916)	1.78854870
98	Hyperalaninemia (HP:0003348)	1.78854870
99	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.78854870
100	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.78638692

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.08116639
2	ZAK	3.80518864
3	TLK1	3.15324963
4	TAOK3	2.92893870
5	MAP4K2	2.71153583
6	KDR	2.45670985
7	NUAK1	2.42677386
8	BLK	2.41516010
9	EIF2AK3	2.40586937
10	TESK2	2.21397058
11	MST4	2.13289907
12	VRK2	2.08201795
13	MAP4K1	2.03721689
14	VRK1	1.88776031
15	ADRBK2	1.85576353
16	BCKDK	1.80286085
17	PASK	1.77220600
18	FRK	1.73939303
19	KIT	1.68177058
20	GRK1	1.64983265
21	STK16	1.58807641
22	SCYL2	1.58681019
23	MAP3K14	1.53453586
24	BMPR2	1.53133143
25	GRK6	1.50360715
26	TEC	1.49609075
27	ITK	1.47437828
28	CDK19	1.46360574
29	IKBKB	1.43271430
30	SYK	1.40090574
31	MAP3K12	1.31234202
32	IKBKE	1.29525350
33	ERBB3	1.27568000
34	BMPR1B	1.24462954
35	FES	1.23979800
36	TRIM28	1.19917763
37	CSF1R	1.02946562
38	TIE1	0.99837623
39	TRPM7	0.95992217
40	WNK4	0.94203528
41	JAK3	0.93467088
42	MAP3K4	0.93119867
43	MYLK	0.92711974
44	TBK1	0.91390163
45	FLT3	0.90046781
46	LYN	0.87960608
47	TSSK6	0.87657644
48	PIK3CG	0.87547797
49	ACVR1B	0.87138811
50	BUB1	0.85665677
51	LCK	0.85416026
52	STK39	0.84946142
53	PRKCQ	0.82092459
54	DAPK1	0.81089467
55	MAPKAPK3	0.79311324
56	MAP2K7	0.78641630
57	OXSR1	0.78331313
58	CDK8	0.75783156
59	EIF2AK2	0.73971604
60	RPS6KA5	0.72904655
61	BTK	0.72249232
62	MATK	0.72123517
63	NEK1	0.71767309
64	PLK4	0.71620264
65	TGFBR1	0.70256071
66	INSRR	0.66739314
67	CSNK1G1	0.66015798
68	PLK3	0.64482529
69	PIM1	0.63370958
70	BRSK2	0.63011486
71	CSNK1G3	0.58952632
72	PBK	0.58078837
73	IGF1R	0.58058496
74	NME1	0.56882741
75	MKNK1	0.56819632
76	RPS6KA4	0.55637112
77	WNK3	0.55214961
78	BCR	0.54739659
79	SRPK1	0.52862839
80	MAP2K2	0.49674937
81	PINK1	0.48713690
82	GRK7	0.48116836
83	ZAP70	0.47243456
84	EIF2AK1	0.45923427
85	MAP2K6	0.43338809
86	HCK	0.42846179
87	NLK	0.42334218
88	MUSK	0.39655144
89	DAPK3	0.37687326
90	ATR	0.34796383
91	PRKCE	0.33021848
92	ADRBK1	0.32928361
93	TAF1	0.31705335
94	RPS6KB2	0.31404042
95	ILK	0.30813841
96	CSNK2A1	0.30758431
97	CSNK1A1L	0.30399811
98	CSK	0.29778418
99	PDK2	0.28264102
100	CDK4	0.26244915

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.65087822
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.54877487
3	Allograft rejection_Homo sapiens_hsa05330	3.23331717
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.03934022
5	Asthma_Homo sapiens_hsa05310	3.01912330
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.01365028
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.99882459
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.70310556
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.25802026
10	RNA polymerase_Homo sapiens_hsa03020	2.14675867
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.11011254
12	Protein export_Homo sapiens_hsa03060	2.05517637
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.02212067
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.01693510
15	Ribosome_Homo sapiens_hsa03010	1.93504911
16	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.83907252
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.72325373
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.67612109
19	Sulfur metabolism_Homo sapiens_hsa00920	1.65402561
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.56310445
21	Caffeine metabolism_Homo sapiens_hsa00232	1.55494445
22	One carbon pool by folate_Homo sapiens_hsa00670	1.44647003
23	RNA degradation_Homo sapiens_hsa03018	1.43309352
24	Homologous recombination_Homo sapiens_hsa03440	1.39405045
25	Parkinsons disease_Homo sapiens_hsa05012	1.30504062
26	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.30374770
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28886019
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.26668224
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.26432097
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.20433601
31	Viral myocarditis_Homo sapiens_hsa05416	1.20002198
32	Basal transcription factors_Homo sapiens_hsa03022	1.19370747
33	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.16558829
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14880727
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.13190008
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09985586
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.08344660
38	Purine metabolism_Homo sapiens_hsa00230	1.08022327
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05254324
40	RNA transport_Homo sapiens_hsa03013	1.03862037
41	Phototransduction_Homo sapiens_hsa04744	1.03328964
42	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.01229303
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00879291
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.00262313
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98665112
46	Leishmaniasis_Homo sapiens_hsa05140	0.96691680
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95904965
48	Herpes simplex infection_Homo sapiens_hsa05168	0.95372907
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.95202547
50	Peroxisome_Homo sapiens_hsa04146	0.93302444
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.93120728
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.91443479
53	Mismatch repair_Homo sapiens_hsa03430	0.88324666
54	Propanoate metabolism_Homo sapiens_hsa00640	0.87948671
55	Spliceosome_Homo sapiens_hsa03040	0.87735703
56	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.87675342
57	Butanoate metabolism_Homo sapiens_hsa00650	0.82782549
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.81209863
59	Measles_Homo sapiens_hsa05162	0.79108511
60	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.78042503
61	DNA replication_Homo sapiens_hsa03030	0.75412843
62	Base excision repair_Homo sapiens_hsa03410	0.74745812
63	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73128855
64	Legionellosis_Homo sapiens_hsa05134	0.70694493
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69867905
66	Glutathione metabolism_Homo sapiens_hsa00480	0.69776120
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.69536079
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62196138
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.61963926
70	Fatty acid elongation_Homo sapiens_hsa00062	0.60507913
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60418160
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60332555
73	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.60021007
74	Retinol metabolism_Homo sapiens_hsa00830	0.60007804
75	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.59670649
76	Huntingtons disease_Homo sapiens_hsa05016	0.59037950
77	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58556150
78	Alzheimers disease_Homo sapiens_hsa05010	0.55875438
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.55743099
80	Nitrogen metabolism_Homo sapiens_hsa00910	0.55605528
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.53297609
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53222431
83	Regulation of autophagy_Homo sapiens_hsa04140	0.53085298
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50645700
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49586522
86	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47754058
87	TNF signaling pathway_Homo sapiens_hsa04668	0.47381403
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47331954
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.46991884
90	Metabolic pathways_Homo sapiens_hsa01100	0.43367298
91	Shigellosis_Homo sapiens_hsa05131	0.42928949
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38091975
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35810841
94	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35777958
95	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.34427037
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33996482
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.33301614
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31064206
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29607940
100	Olfactory transduction_Homo sapiens_hsa04740	0.25332825

EEF1A1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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