EEF1A1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.58373296
2ATP synthesis coupled proton transport (GO:0015986)4.82000076
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.82000076
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.47341404
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.35059866
6ribosomal small subunit assembly (GO:0000028)4.29037858
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.07204266
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.07204266
9water-soluble vitamin biosynthetic process (GO:0042364)3.68232350
10proteasome assembly (GO:0043248)3.63848888
11protein complex biogenesis (GO:0070271)3.62158732
12cytidine metabolic process (GO:0046087)3.61877512
13cytidine catabolic process (GO:0006216)3.61877512
14cytidine deamination (GO:0009972)3.61877512
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57500704
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.43571770
17NADH dehydrogenase complex assembly (GO:0010257)3.43571770
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43571770
19nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41212510
20mitochondrial respiratory chain complex assembly (GO:0033108)3.34511589
21regulation of cellular amino acid metabolic process (GO:0006521)3.32900043
22platelet dense granule organization (GO:0060155)3.28756624
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27797308
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.25098547
25electron transport chain (GO:0022900)3.21885046
26mannosylation (GO:0097502)3.21208047
27respiratory electron transport chain (GO:0022904)3.20748527
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18437886
29pyrimidine ribonucleoside catabolic process (GO:0046133)3.17112298
30GTP biosynthetic process (GO:0006183)3.16300472
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09178871
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09178871
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09178871
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08200123
35ribosomal large subunit biogenesis (GO:0042273)3.06867197
36intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06036215
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06036215
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.05924757
39sequestering of actin monomers (GO:0042989)3.03198406
40positive regulation of T cell mediated cytotoxicity (GO:0001916)3.01100870
41establishment of protein localization to mitochondrial membrane (GO:0090151)2.99848431
42signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95715396
43signal transduction involved in DNA damage checkpoint (GO:0072422)2.95715396
44pseudouridine synthesis (GO:0001522)2.95247057
45regulation of regulatory T cell differentiation (GO:0045589)2.93636181
46signal transduction involved in cell cycle checkpoint (GO:0072395)2.92460043
47purine nucleoside triphosphate biosynthetic process (GO:0009145)2.92008923
48metallo-sulfur cluster assembly (GO:0031163)2.91694487
49iron-sulfur cluster assembly (GO:0016226)2.91694487
50behavioral response to nicotine (GO:0035095)2.90148270
51adenosine metabolic process (GO:0046085)2.89267125
52respiratory chain complex IV assembly (GO:0008535)2.88629910
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87946544
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86590760
55protein neddylation (GO:0045116)2.86511520
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85878492
57negative regulation of ligase activity (GO:0051352)2.85878492
58GPI anchor metabolic process (GO:0006505)2.85226967
59cullin deneddylation (GO:0010388)2.82933733
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81393478
61preassembly of GPI anchor in ER membrane (GO:0016254)2.81379059
62positive regulation of prostaglandin secretion (GO:0032308)2.81332058
63ATP biosynthetic process (GO:0006754)2.78992672
64positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.78287867
65rRNA modification (GO:0000154)2.77112372
66regulation of T cell mediated cytotoxicity (GO:0001914)2.77093980
67cellular response to interleukin-15 (GO:0071350)2.77032182
68base-excision repair, AP site formation (GO:0006285)2.75312730
69response to pheromone (GO:0019236)2.75161185
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.74206334
71protein deneddylation (GO:0000338)2.73619199
72regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.72418104
73GPI anchor biosynthetic process (GO:0006506)2.71901402
74positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.71816147
75termination of RNA polymerase III transcription (GO:0006386)2.69752038
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.69752038
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69682628
78xenobiotic catabolic process (GO:0042178)2.67995815
79proton transport (GO:0015992)2.67383185
80hydrogen ion transmembrane transport (GO:1902600)2.67231998
81positive regulation of defense response to virus by host (GO:0002230)2.65936247
82rRNA catabolic process (GO:0016075)2.65283920
83cytochrome complex assembly (GO:0017004)2.64732374
84tRNA processing (GO:0008033)2.61086430
85hydrogen transport (GO:0006818)2.60681998
86UTP metabolic process (GO:0046051)2.60629380
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60403834
88negative T cell selection (GO:0043383)2.59319327
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.58649596
90detection of light stimulus involved in visual perception (GO:0050908)2.58641392
91detection of light stimulus involved in sensory perception (GO:0050962)2.58641392
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.57797477
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57775219
94translational elongation (GO:0006414)2.56706555
95UTP biosynthetic process (GO:0006228)2.56684722
96maturation of 5.8S rRNA (GO:0000460)2.56661876
97viral transcription (GO:0019083)2.55085812
98translation (GO:0006412)2.54815743
99regulation of chronic inflammatory response (GO:0002676)2.53745199
100cotranslational protein targeting to membrane (GO:0006613)2.53701056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.21657933
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.18260666
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.90206834
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.89834576
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.45864210
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.44933908
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.13960363
8VDR_22108803_ChIP-Seq_LS180_Human3.07225805
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95769708
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81646350
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81035987
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.75727800
13VDR_23849224_ChIP-Seq_CD4+_Human2.72382374
14ZNF274_21170338_ChIP-Seq_K562_Hela2.58169334
15ELK1_19687146_ChIP-ChIP_HELA_Human2.38328404
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.37742053
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.17469633
18FOXP3_21729870_ChIP-Seq_TREG_Human2.16874214
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06816987
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00867528
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.99780610
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99632623
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.95756277
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94135349
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90818862
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.89695819
27MYC_18940864_ChIP-ChIP_HL60_Human1.86419015
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76200847
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63768661
30IGF1R_20145208_ChIP-Seq_DFB_Human1.53452132
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50455861
32EWS_26573619_Chip-Seq_HEK293_Human1.48243081
33TP53_22573176_ChIP-Seq_HFKS_Human1.43037417
34GATA3_26560356_Chip-Seq_TH2_Human1.42713354
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42429849
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41910010
37IRF1_19129219_ChIP-ChIP_H3396_Human1.39959372
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39678395
39AR_20517297_ChIP-Seq_VCAP_Human1.38135199
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.35750927
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.35668039
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35668039
43ELK1_22589737_ChIP-Seq_MCF10A_Human1.32449332
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30526796
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.30317114
46MYB_26560356_Chip-Seq_TH2_Human1.30251931
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29052949
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27354088
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27057902
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25295604
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24043272
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22269226
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21472921
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21209422
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19774092
56EZH2_22144423_ChIP-Seq_EOC_Human1.19440428
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17568078
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16862830
59P300_19829295_ChIP-Seq_ESCs_Human1.16401075
60ER_23166858_ChIP-Seq_MCF-7_Human1.16292156
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15976441
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15655268
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13086837
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12822467
65TAF15_26573619_Chip-Seq_HEK293_Human1.12608334
66NANOG_19829295_ChIP-Seq_ESCs_Human1.10490582
67SOX2_19829295_ChIP-Seq_ESCs_Human1.10490582
68AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10436916
69NCOR_22424771_ChIP-Seq_293T_Human1.08927440
70DCP1A_22483619_ChIP-Seq_HELA_Human1.08498689
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06413500
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05789501
73NANOG_20526341_ChIP-Seq_ESCs_Human1.05378628
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05036746
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04736378
76GABP_19822575_ChIP-Seq_HepG2_Human1.04635412
77IRF8_21731497_ChIP-ChIP_J774_Mouse1.03546951
78FUS_26573619_Chip-Seq_HEK293_Human1.03366441
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02555337
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01919215
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01089137
82TTF2_22483619_ChIP-Seq_HELA_Human1.00743243
83FOXH1_21741376_ChIP-Seq_EPCs_Human1.00676235
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99527421
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99272515
86CIITA_25753668_ChIP-Seq_RAJI_Human0.99227436
87EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99015608
88GATA3_27048872_Chip-Seq_THYMUS_Human0.98340769
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98052231
90BCAT_22108803_ChIP-Seq_LS180_Human0.96049557
91TAF2_19829295_ChIP-Seq_ESCs_Human0.95668344
92GATA3_21878914_ChIP-Seq_MCF-7_Human0.95283330
93FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94789845
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94643549
95CBP_20019798_ChIP-Seq_JUKART_Human0.94643549
96BP1_19119308_ChIP-ChIP_Hs578T_Human0.93432852
97ERG_20517297_ChIP-Seq_VCAP_Human0.93194355
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.93134310
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93058694
100PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92993113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.59656721
2MP0002163_abnormal_gland_morphology3.24802842
3MP0002102_abnormal_ear_morphology2.82139191
4MP0001835_abnormal_antigen_presentation2.74423989
5MP0008877_abnormal_DNA_methylation2.55865926
6MP0005645_abnormal_hypothalamus_physiol2.44520823
7MP0006072_abnormal_retinal_apoptosis2.37375146
8MP0005379_endocrine/exocrine_gland_phen2.32409443
9MP0008875_abnormal_xenobiotic_pharmacok2.29979408
10MP0004147_increased_porphyrin_level2.22118058
11MP0008872_abnormal_physiological_respon2.12464502
12MP0002138_abnormal_hepatobiliary_system2.08222566
13MP0009785_altered_susceptibility_to2.04485360
14MP0002166_altered_tumor_susceptibility1.96811224
15MP0005084_abnormal_gallbladder_morpholo1.92370775
16MP0002148_abnormal_hypersensitivity_rea1.89359604
17MP0003763_abnormal_thymus_physiology1.86797368
18MP0002876_abnormal_thyroid_physiology1.79699863
19MP0001800_abnormal_humoral_immune1.78901901
20MP0005551_abnormal_eye_electrophysiolog1.78316973
21MP0002006_tumorigenesis1.77668643
22MP0003866_abnormal_defecation1.76316268
23MP0002736_abnormal_nociception_after1.74886843
24MP0003195_calcinosis1.71124342
25MP0005646_abnormal_pituitary_gland1.65782927
26MP0005000_abnormal_immune_tolerance1.65127034
27MP0000685_abnormal_immune_system1.60610438
28MP0003786_premature_aging1.56891213
29MP0005360_urolithiasis1.53434117
30MP0001968_abnormal_touch/_nociception1.52483074
31MP0003011_delayed_dark_adaptation1.50159375
32MP0002723_abnormal_immune_serum1.48414203
33MP0003724_increased_susceptibility_to1.46223857
34MP0008058_abnormal_DNA_repair1.45359600
35MP0003646_muscle_fatigue1.44483402
36MP0005075_abnormal_melanosome_morpholog1.43174739
37MP0005253_abnormal_eye_physiology1.42394192
38MP0004885_abnormal_endolymph1.42174065
39MP0001919_abnormal_reproductive_system1.41684567
40MP0002837_dystrophic_cardiac_calcinosis1.41347385
41MP0002420_abnormal_adaptive_immunity1.39362130
42MP0002277_abnormal_respiratory_mucosa1.39284577
43MP0001819_abnormal_immune_cell1.38508695
44MP0005389_reproductive_system_phenotype1.37537799
45MP0001873_stomach_inflammation1.36942889
46MP0002452_abnormal_antigen_presenting1.35061435
47MP0009333_abnormal_splenocyte_physiolog1.31223076
48MP0000372_irregular_coat_pigmentation1.26627975
49MP0001905_abnormal_dopamine_level1.26611059
50MP0004142_abnormal_muscle_tone1.26588583
51MP0006292_abnormal_olfactory_placode1.25188664
52MP0005387_immune_system_phenotype1.25123457
53MP0001790_abnormal_immune_system1.25123457
54MP0005410_abnormal_fertilization1.23826433
55MP0005377_hearing/vestibular/ear_phenot1.22646492
56MP0003878_abnormal_ear_physiology1.22646492
57MP0006035_abnormal_mitochondrial_morpho1.21797932
58MP0001986_abnormal_taste_sensitivity1.20060701
59MP0009764_decreased_sensitivity_to1.19804096
60MP0003806_abnormal_nucleotide_metabolis1.18465133
61MP0001764_abnormal_homeostasis1.08857156
62MP0003252_abnormal_bile_duct1.07996242
63MP0004145_abnormal_muscle_electrophysio1.07336240
64MP0005025_abnormal_response_to1.07045065
65MP0009379_abnormal_foot_pigmentation1.04592714
66MP0008995_early_reproductive_senescence1.02381689
67MP0000613_abnormal_salivary_gland1.01033316
68MP0000689_abnormal_spleen_morphology1.00850063
69MP0003718_maternal_effect1.00510764
70MP0000716_abnormal_immune_system1.00039255
71MP0001845_abnormal_inflammatory_respons0.99607879
72MP0006036_abnormal_mitochondrial_physio0.97214106
73MP0003436_decreased_susceptibility_to0.97148131
74MP0001529_abnormal_vocalization0.95433290
75MP0002160_abnormal_reproductive_system0.95058460
76MP0003880_abnormal_central_pattern0.94645276
77MP0002398_abnormal_bone_marrow0.92566123
78MP0005085_abnormal_gallbladder_physiolo0.92190834
79MP0005167_abnormal_blood-brain_barrier0.90967675
80MP0005636_abnormal_mineral_homeostasis0.90636453
81MP0005365_abnormal_bile_salt0.90556394
82MP0001501_abnormal_sleep_pattern0.89412483
83MP0006276_abnormal_autonomic_nervous0.87302608
84MP0001119_abnormal_female_reproductive0.85815962
85MP0005332_abnormal_amino_acid0.85783375
86MP0002938_white_spotting0.85418557
87MP0002722_abnormal_immune_system0.84444213
88MP0000647_abnormal_sebaceous_gland0.84285073
89MP0010155_abnormal_intestine_physiology0.84182454
90MP0002405_respiratory_system_inflammati0.81892905
91MP0002272_abnormal_nervous_system0.81540302
92MP0002693_abnormal_pancreas_physiology0.80625716
93MP0008469_abnormal_protein_level0.79840526
94MP0002638_abnormal_pupillary_reflex0.78759528
95MP0003186_abnormal_redox_activity0.77192427
96MP0000703_abnormal_thymus_morphology0.76644217
97MP0001765_abnormal_ion_homeostasis0.75803427
98MP0002429_abnormal_blood_cell0.75117055
99MP0000465_gastrointestinal_hemorrhage0.74387528
100MP0001929_abnormal_gametogenesis0.73449249

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)3.93181457
2Acute necrotizing encephalopathy (HP:0006965)3.92569587
3Mitochondrial inheritance (HP:0001427)3.73254870
4Abnormal mitochondria in muscle tissue (HP:0008316)3.53506843
5Acute encephalopathy (HP:0006846)3.46269584
6Congenital stationary night blindness (HP:0007642)3.34769724
7Increased CSF lactate (HP:0002490)3.32477830
8Progressive macrocephaly (HP:0004481)3.31680624
9Pancreatic cysts (HP:0001737)3.30783279
10Abnormality of alanine metabolism (HP:0010916)3.26413797
11Hyperalaninemia (HP:0003348)3.26413797
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26413797
133-Methylglutaconic aciduria (HP:0003535)3.12244366
14Hepatocellular necrosis (HP:0001404)3.06892416
15Methylmalonic acidemia (HP:0002912)3.06495864
16Increased hepatocellular lipid droplets (HP:0006565)3.06368611
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.04914220
18Lipid accumulation in hepatocytes (HP:0006561)3.03910634
19Abnormality of the renal cortex (HP:0011035)2.95730083
20Elevated erythrocyte sedimentation rate (HP:0003565)2.95669060
21Hepatic necrosis (HP:0002605)2.91821826
22Renal cortical cysts (HP:0000803)2.86456395
23Pancreatic fibrosis (HP:0100732)2.82766208
24Aplastic anemia (HP:0001915)2.79935432
25Severe combined immunodeficiency (HP:0004430)2.79133729
26Attenuation of retinal blood vessels (HP:0007843)2.77494988
27True hermaphroditism (HP:0010459)2.76641131
28Stomatitis (HP:0010280)2.73102394
29Abnormal rod and cone electroretinograms (HP:0008323)2.72721328
30Congenital, generalized hypertrichosis (HP:0004540)2.68766959
31Hypoproteinemia (HP:0003075)2.67712204
32Abolished electroretinogram (ERG) (HP:0000550)2.62762596
33Methylmalonic aciduria (HP:0012120)2.59292852
34Cerebral edema (HP:0002181)2.56902545
35Optic disc pallor (HP:0000543)2.50630525
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.47315609
37Increased serum lactate (HP:0002151)2.46197974
38Abnormality of T cell number (HP:0011839)2.42341121
39Constricted visual fields (HP:0001133)2.41854814
40Renal Fanconi syndrome (HP:0001994)2.39991669
41Abnormality of the prostate (HP:0008775)2.39269092
42Lactic acidosis (HP:0003128)2.39252184
43Increased intramyocellular lipid droplets (HP:0012240)2.35180638
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34982992
45T lymphocytopenia (HP:0005403)2.32172028
46Abnormality of the pons (HP:0007361)2.31883806
47Molar tooth sign on MRI (HP:0002419)2.31851420
48Abnormality of midbrain morphology (HP:0002418)2.31851420
49Abnormality of T cells (HP:0002843)2.28138257
50Prostate neoplasm (HP:0100787)2.25925162
51Thyroiditis (HP:0100646)2.24759348
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24676611
53Increased IgM level (HP:0003496)2.22998136
54Abnormal number of erythroid precursors (HP:0012131)2.20680828
55Hypoplasia of the pons (HP:0012110)2.20370759
56Abnormality of B cell number (HP:0010975)2.20021303
57Pancytopenia (HP:0001876)2.19836638
58Aplasia/hypoplasia of the uterus (HP:0008684)2.18200908
59Nephronophthisis (HP:0000090)2.16290460
60Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16015951
61Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16015951
62Decreased central vision (HP:0007663)2.14676669
63Abnormality of serum amino acid levels (HP:0003112)2.10732414
64Type II lissencephaly (HP:0007260)2.07042186
65Absent thumb (HP:0009777)2.06760411
66Exertional dyspnea (HP:0002875)2.06696477
67Type I transferrin isoform profile (HP:0003642)2.06348321
68Lethargy (HP:0001254)2.04852123
69Combined immunodeficiency (HP:0005387)2.04344712
70Abnormality of eosinophils (HP:0001879)2.04109522
71Abnormality of T cell physiology (HP:0011840)2.03449100
72Increased muscle lipid content (HP:0009058)2.02997300
73Pendular nystagmus (HP:0012043)2.01473481
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00999359
75Sclerocornea (HP:0000647)1.98417689
76Short tibia (HP:0005736)1.97509817
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96363901
78Dicarboxylic aciduria (HP:0003215)1.96363901
79Polydipsia (HP:0001959)1.95949612
80Abnormal drinking behavior (HP:0030082)1.95949612
81Respiratory failure (HP:0002878)1.95827496
82Abnormality of the renal medulla (HP:0100957)1.94369133
83Abnormality of cells of the erythroid lineage (HP:0012130)1.94136776
84Stomach cancer (HP:0012126)1.94007808
85Hypoplasia of the uterus (HP:0000013)1.93986636
86Type 2 muscle fiber atrophy (HP:0003554)1.93970713
87Glycosuria (HP:0003076)1.92906546
88Abnormality of urine glucose concentration (HP:0011016)1.92906546
89Oral leukoplakia (HP:0002745)1.92647056
90Bile duct proliferation (HP:0001408)1.92402061
91Abnormal biliary tract physiology (HP:0012439)1.92402061
92Generalized aminoaciduria (HP:0002909)1.90503543
93Hyperglycinemia (HP:0002154)1.85596857
94Abnormality of the vitamin B12 metabolism (HP:0004341)1.85302973
95Increased corneal curvature (HP:0100692)1.82723119
96Keratoconus (HP:0000563)1.82723119
97Abnormality of vitamin B metabolism (HP:0004340)1.80555175
98Medial flaring of the eyebrow (HP:0010747)1.80394145
99B lymphocytopenia (HP:0010976)1.78974422
100Panhypogammaglobulinemia (HP:0003139)1.78927312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.16436184
2ZAK3.88288986
3TXK3.71735822
4VRK23.12140737
5MAP4K22.88040580
6TAOK32.61151082
7NUAK12.50231848
8BUB12.47516296
9VRK12.32417025
10KDR2.29593104
11ADRBK22.27119295
12TESK22.12969989
13BCKDK1.99426659
14MST41.96393688
15GRK11.89593952
16PASK1.84534759
17FRK1.79177107
18MAP3K121.70529317
19CDK191.62030373
20STK161.57751095
21PINK11.53043159
22MUSK1.48053224
23FES1.30757200
24GRK61.29483229
25MAP4K11.25408373
26WNK31.24277984
27ITK1.21450184
28LIMK11.17096879
29WNK41.16543112
30EIF2AK31.14897534
31INSRR1.14486908
32IKBKB1.11785270
33TEC1.10431262
34RPS6KA51.06929744
35TRIM281.05836296
36SCYL21.03844157
37NEK11.00666215
38CSNK1G30.97027302
39SYK0.94736665
40TIE10.94269034
41OXSR10.93625476
42NME10.92624245
43LMTK20.91897526
44IKBKE0.90575949
45KIT0.89971905
46BMPR20.89543228
47DAPK10.88556499
48ERBB30.85516819
49MAP2K20.83114918
50CSNK1G20.78922499
51MYLK0.78059676
52CAMKK20.76021558
53TSSK60.75860334
54CSNK1G10.73271368
55CSNK1A1L0.72439144
56BMPR1B0.70037922
57EIF2AK20.68412118
58PRKCQ0.67062328
59SRPK10.64788529
60TAF10.64604802
61LCK0.63184337
62PLK30.62414765
63PHKG20.60658379
64PHKG10.60658379
65RPS6KA40.59489462
66LYN0.59242481
67DYRK20.57662867
68ADRBK10.54875953
69MAP2K70.53724735
70TRPM70.53406048
71BCR0.52946278
72CSF1R0.52756997
73STK390.52545745
74BTK0.51904100
75MAPKAPK30.50949548
76IGF1R0.49384019
77PLK40.47860450
78MAP3K140.47201560
79DAPK30.46456064
80TESK10.45462756
81PIM10.44128252
82TBK10.43976926
83GRK70.43584968
84AURKA0.41920300
85AURKB0.40716977
86FLT30.38845056
87PRKCE0.38200085
88GRK50.36411083
89PLK10.36333703
90CSNK2A10.36181282
91ZAP700.36141285
92ATR0.35811411
93MAP3K40.33840493
94PIK3CG0.32757328
95CDK80.32395754
96MKNK10.31461388
97MAP2K60.30883705
98CSNK1A10.29782030
99ACVR1B0.29238189
100PTK2B0.28341560

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.04419767
2Oxidative phosphorylation_Homo sapiens_hsa001903.27512301
3Primary immunodeficiency_Homo sapiens_hsa053402.95305769
4Ribosome_Homo sapiens_hsa030102.95032277
5Parkinsons disease_Homo sapiens_hsa050122.59357489
6Asthma_Homo sapiens_hsa053102.37089360
7Allograft rejection_Homo sapiens_hsa053302.35237907
8Protein export_Homo sapiens_hsa030602.31823208
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.25817136
10Autoimmune thyroid disease_Homo sapiens_hsa053202.22306395
11Graft-versus-host disease_Homo sapiens_hsa053322.20945166
12RNA polymerase_Homo sapiens_hsa030202.10312349
13Type I diabetes mellitus_Homo sapiens_hsa049402.00949209
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.93863787
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86708801
16Antigen processing and presentation_Homo sapiens_hsa046121.85292671
17Nitrogen metabolism_Homo sapiens_hsa009101.71698231
18Alzheimers disease_Homo sapiens_hsa050101.63316028
19Huntingtons disease_Homo sapiens_hsa050161.62002680
20RNA degradation_Homo sapiens_hsa030181.61284157
21Systemic lupus erythematosus_Homo sapiens_hsa053221.60091163
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58553004
23One carbon pool by folate_Homo sapiens_hsa006701.57908542
24Phototransduction_Homo sapiens_hsa047441.50309140
25Linoleic acid metabolism_Homo sapiens_hsa005911.49820949
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46289581
27Homologous recombination_Homo sapiens_hsa034401.46051386
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39844463
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38780567
30Basal transcription factors_Homo sapiens_hsa030221.33391665
31Mismatch repair_Homo sapiens_hsa034301.26947796
32Cardiac muscle contraction_Homo sapiens_hsa042601.23258549
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.23121987
34Sulfur metabolism_Homo sapiens_hsa009201.22846353
35Spliceosome_Homo sapiens_hsa030401.22543276
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21878257
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20903228
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17185022
39Fanconi anemia pathway_Homo sapiens_hsa034601.16159962
40Hematopoietic cell lineage_Homo sapiens_hsa046401.14179956
41Propanoate metabolism_Homo sapiens_hsa006401.13112096
42Nucleotide excision repair_Homo sapiens_hsa034201.12154125
43Peroxisome_Homo sapiens_hsa041461.10945251
44Caffeine metabolism_Homo sapiens_hsa002321.10342875
45Rheumatoid arthritis_Homo sapiens_hsa053231.08013909
46Pyrimidine metabolism_Homo sapiens_hsa002401.06349453
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01427985
48DNA replication_Homo sapiens_hsa030300.99331529
49Tryptophan metabolism_Homo sapiens_hsa003800.98079481
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.97431813
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94419256
52Base excision repair_Homo sapiens_hsa034100.92246258
53Purine metabolism_Homo sapiens_hsa002300.90795014
54Butanoate metabolism_Homo sapiens_hsa006500.88081130
55RNA transport_Homo sapiens_hsa030130.87517855
56Chemical carcinogenesis_Homo sapiens_hsa052040.83406050
57Arachidonic acid metabolism_Homo sapiens_hsa005900.82989069
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80757984
59T cell receptor signaling pathway_Homo sapiens_hsa046600.78313916
60Fat digestion and absorption_Homo sapiens_hsa049750.75031413
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.73238831
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73170883
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71563271
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69462976
65Ether lipid metabolism_Homo sapiens_hsa005650.69174461
66Selenocompound metabolism_Homo sapiens_hsa004500.69015172
67Non-homologous end-joining_Homo sapiens_hsa034500.67825917
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66812562
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66178174
70Retinol metabolism_Homo sapiens_hsa008300.65987335
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.65949969
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65939580
73Regulation of autophagy_Homo sapiens_hsa041400.63700368
74Viral myocarditis_Homo sapiens_hsa054160.62482233
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59088641
76Metabolic pathways_Homo sapiens_hsa011000.58664400
77Glutathione metabolism_Homo sapiens_hsa004800.58458933
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.56592567
79Sulfur relay system_Homo sapiens_hsa041220.56076126
80Alcoholism_Homo sapiens_hsa050340.53410626
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52712168
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49858480
83Collecting duct acid secretion_Homo sapiens_hsa049660.49375859
84Fatty acid elongation_Homo sapiens_hsa000620.46284816
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44962160
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41579189
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41544666
88Olfactory transduction_Homo sapiens_hsa047400.40997995
89Taste transduction_Homo sapiens_hsa047420.39297647
90Pyruvate metabolism_Homo sapiens_hsa006200.33908887
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.32319023
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32015967
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.31175801
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31038933
95Herpes simplex infection_Homo sapiens_hsa051680.30405955
96Nicotine addiction_Homo sapiens_hsa050330.30004035
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27670159
98Epstein-Barr virus infection_Homo sapiens_hsa051690.25937279
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24415161
100Legionellosis_Homo sapiens_hsa051340.23344488

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