ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.58373296
2	ATP synthesis coupled proton transport (GO:0015986)	4.82000076
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.82000076
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.47341404
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.35059866
6	ribosomal small subunit assembly (GO:0000028)	4.29037858
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.07204266
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.07204266
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.68232350
10	proteasome assembly (GO:0043248)	3.63848888
11	protein complex biogenesis (GO:0070271)	3.62158732
12	cytidine metabolic process (GO:0046087)	3.61877512
13	cytidine catabolic process (GO:0006216)	3.61877512
14	cytidine deamination (GO:0009972)	3.61877512
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.57500704
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.43571770
17	NADH dehydrogenase complex assembly (GO:0010257)	3.43571770
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.43571770
19	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.41212510
20	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34511589
21	regulation of cellular amino acid metabolic process (GO:0006521)	3.32900043
22	platelet dense granule organization (GO:0060155)	3.28756624
23	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.27797308
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.25098547
25	electron transport chain (GO:0022900)	3.21885046
26	mannosylation (GO:0097502)	3.21208047
27	respiratory electron transport chain (GO:0022904)	3.20748527
28	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.18437886
29	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.17112298
30	GTP biosynthetic process (GO:0006183)	3.16300472
31	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.09178871
32	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.09178871
33	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.09178871
34	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.08200123
35	ribosomal large subunit biogenesis (GO:0042273)	3.06867197
36	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.06036215
37	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.06036215
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.05924757
39	sequestering of actin monomers (GO:0042989)	3.03198406
40	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.01100870
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.99848431
42	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.95715396
43	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.95715396
44	pseudouridine synthesis (GO:0001522)	2.95247057
45	regulation of regulatory T cell differentiation (GO:0045589)	2.93636181
46	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.92460043
47	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.92008923
48	metallo-sulfur cluster assembly (GO:0031163)	2.91694487
49	iron-sulfur cluster assembly (GO:0016226)	2.91694487
50	behavioral response to nicotine (GO:0035095)	2.90148270
51	adenosine metabolic process (GO:0046085)	2.89267125
52	respiratory chain complex IV assembly (GO:0008535)	2.88629910
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.87946544
54	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.86590760
55	protein neddylation (GO:0045116)	2.86511520
56	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.85878492
57	negative regulation of ligase activity (GO:0051352)	2.85878492
58	GPI anchor metabolic process (GO:0006505)	2.85226967
59	cullin deneddylation (GO:0010388)	2.82933733
60	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.81393478
61	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81379059
62	positive regulation of prostaglandin secretion (GO:0032308)	2.81332058
63	ATP biosynthetic process (GO:0006754)	2.78992672
64	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.78287867
65	rRNA modification (GO:0000154)	2.77112372
66	regulation of T cell mediated cytotoxicity (GO:0001914)	2.77093980
67	cellular response to interleukin-15 (GO:0071350)	2.77032182
68	base-excision repair, AP site formation (GO:0006285)	2.75312730
69	response to pheromone (GO:0019236)	2.75161185
70	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.74206334
71	protein deneddylation (GO:0000338)	2.73619199
72	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.72418104
73	GPI anchor biosynthetic process (GO:0006506)	2.71901402
74	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.71816147
75	termination of RNA polymerase III transcription (GO:0006386)	2.69752038
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69752038
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.69682628
78	xenobiotic catabolic process (GO:0042178)	2.67995815
79	proton transport (GO:0015992)	2.67383185
80	hydrogen ion transmembrane transport (GO:1902600)	2.67231998
81	positive regulation of defense response to virus by host (GO:0002230)	2.65936247
82	rRNA catabolic process (GO:0016075)	2.65283920
83	cytochrome complex assembly (GO:0017004)	2.64732374
84	tRNA processing (GO:0008033)	2.61086430
85	hydrogen transport (GO:0006818)	2.60681998
86	UTP metabolic process (GO:0046051)	2.60629380
87	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.60403834
88	negative T cell selection (GO:0043383)	2.59319327
89	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.58649596
90	detection of light stimulus involved in visual perception (GO:0050908)	2.58641392
91	detection of light stimulus involved in sensory perception (GO:0050962)	2.58641392
92	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.57797477
93	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.57775219
94	translational elongation (GO:0006414)	2.56706555
95	UTP biosynthetic process (GO:0006228)	2.56684722
96	maturation of 5.8S rRNA (GO:0000460)	2.56661876
97	viral transcription (GO:0019083)	2.55085812
98	translation (GO:0006412)	2.54815743
99	regulation of chronic inflammatory response (GO:0002676)	2.53745199
100	cotranslational protein targeting to membrane (GO:0006613)	2.53701056

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.21657933
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.18260666
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.90206834
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.89834576
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.45864210
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.44933908
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.13960363
8	VDR_22108803_ChIP-Seq_LS180_Human	3.07225805
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95769708
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.81646350
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.81035987
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.75727800
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.72382374
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58169334
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.38328404
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.37742053
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.17469633
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16874214
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.06816987
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.00867528
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.99780610
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.99632623
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.95756277
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94135349
25	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.90818862
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89695819
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.86419015
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.76200847
29	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.63768661
30	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53452132
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.50455861
32	EWS_26573619_Chip-Seq_HEK293_Human	1.48243081
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.43037417
34	GATA3_26560356_Chip-Seq_TH2_Human	1.42713354
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.42429849
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41910010
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39959372
38	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.39678395
39	AR_20517297_ChIP-Seq_VCAP_Human	1.38135199
40	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35750927
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35668039
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35668039
43	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.32449332
44	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30526796
45	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30317114
46	MYB_26560356_Chip-Seq_TH2_Human	1.30251931
47	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.29052949
48	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.27354088
49	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.27057902
50	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.25295604
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24043272
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.22269226
53	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21472921
54	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.21209422
55	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.19774092
56	EZH2_22144423_ChIP-Seq_EOC_Human	1.19440428
57	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17568078
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16862830
59	P300_19829295_ChIP-Seq_ESCs_Human	1.16401075
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.16292156
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15976441
62	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15655268
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.13086837
64	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.12822467
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.12608334
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10490582
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10490582
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10436916
69	NCOR_22424771_ChIP-Seq_293T_Human	1.08927440
70	DCP1A_22483619_ChIP-Seq_HELA_Human	1.08498689
71	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06413500
72	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.05789501
73	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05378628
74	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.05036746
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.04736378
76	GABP_19822575_ChIP-Seq_HepG2_Human	1.04635412
77	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.03546951
78	FUS_26573619_Chip-Seq_HEK293_Human	1.03366441
79	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02555337
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.01919215
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.01089137
82	TTF2_22483619_ChIP-Seq_HELA_Human	1.00743243
83	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00676235
84	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99527421
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99272515
86	CIITA_25753668_ChIP-Seq_RAJI_Human	0.99227436
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.99015608
88	GATA3_27048872_Chip-Seq_THYMUS_Human	0.98340769
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98052231
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.96049557
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95668344
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95283330
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.94789845
94	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94643549
95	CBP_20019798_ChIP-Seq_JUKART_Human	0.94643549
96	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.93432852
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.93194355
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93134310
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93058694
100	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92993113

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.59656721
2	MP0002163_abnormal_gland_morphology	3.24802842
3	MP0002102_abnormal_ear_morphology	2.82139191
4	MP0001835_abnormal_antigen_presentation	2.74423989
5	MP0008877_abnormal_DNA_methylation	2.55865926
6	MP0005645_abnormal_hypothalamus_physiol	2.44520823
7	MP0006072_abnormal_retinal_apoptosis	2.37375146
8	MP0005379_endocrine/exocrine_gland_phen	2.32409443
9	MP0008875_abnormal_xenobiotic_pharmacok	2.29979408
10	MP0004147_increased_porphyrin_level	2.22118058
11	MP0008872_abnormal_physiological_respon	2.12464502
12	MP0002138_abnormal_hepatobiliary_system	2.08222566
13	MP0009785_altered_susceptibility_to	2.04485360
14	MP0002166_altered_tumor_susceptibility	1.96811224
15	MP0005084_abnormal_gallbladder_morpholo	1.92370775
16	MP0002148_abnormal_hypersensitivity_rea	1.89359604
17	MP0003763_abnormal_thymus_physiology	1.86797368
18	MP0002876_abnormal_thyroid_physiology	1.79699863
19	MP0001800_abnormal_humoral_immune	1.78901901
20	MP0005551_abnormal_eye_electrophysiolog	1.78316973
21	MP0002006_tumorigenesis	1.77668643
22	MP0003866_abnormal_defecation	1.76316268
23	MP0002736_abnormal_nociception_after	1.74886843
24	MP0003195_calcinosis	1.71124342
25	MP0005646_abnormal_pituitary_gland	1.65782927
26	MP0005000_abnormal_immune_tolerance	1.65127034
27	MP0000685_abnormal_immune_system	1.60610438
28	MP0003786_premature_aging	1.56891213
29	MP0005360_urolithiasis	1.53434117
30	MP0001968_abnormal_touch/_nociception	1.52483074
31	MP0003011_delayed_dark_adaptation	1.50159375
32	MP0002723_abnormal_immune_serum	1.48414203
33	MP0003724_increased_susceptibility_to	1.46223857
34	MP0008058_abnormal_DNA_repair	1.45359600
35	MP0003646_muscle_fatigue	1.44483402
36	MP0005075_abnormal_melanosome_morpholog	1.43174739
37	MP0005253_abnormal_eye_physiology	1.42394192
38	MP0004885_abnormal_endolymph	1.42174065
39	MP0001919_abnormal_reproductive_system	1.41684567
40	MP0002837_dystrophic_cardiac_calcinosis	1.41347385
41	MP0002420_abnormal_adaptive_immunity	1.39362130
42	MP0002277_abnormal_respiratory_mucosa	1.39284577
43	MP0001819_abnormal_immune_cell	1.38508695
44	MP0005389_reproductive_system_phenotype	1.37537799
45	MP0001873_stomach_inflammation	1.36942889
46	MP0002452_abnormal_antigen_presenting	1.35061435
47	MP0009333_abnormal_splenocyte_physiolog	1.31223076
48	MP0000372_irregular_coat_pigmentation	1.26627975
49	MP0001905_abnormal_dopamine_level	1.26611059
50	MP0004142_abnormal_muscle_tone	1.26588583
51	MP0006292_abnormal_olfactory_placode	1.25188664
52	MP0005387_immune_system_phenotype	1.25123457
53	MP0001790_abnormal_immune_system	1.25123457
54	MP0005410_abnormal_fertilization	1.23826433
55	MP0005377_hearing/vestibular/ear_phenot	1.22646492
56	MP0003878_abnormal_ear_physiology	1.22646492
57	MP0006035_abnormal_mitochondrial_morpho	1.21797932
58	MP0001986_abnormal_taste_sensitivity	1.20060701
59	MP0009764_decreased_sensitivity_to	1.19804096
60	MP0003806_abnormal_nucleotide_metabolis	1.18465133
61	MP0001764_abnormal_homeostasis	1.08857156
62	MP0003252_abnormal_bile_duct	1.07996242
63	MP0004145_abnormal_muscle_electrophysio	1.07336240
64	MP0005025_abnormal_response_to	1.07045065
65	MP0009379_abnormal_foot_pigmentation	1.04592714
66	MP0008995_early_reproductive_senescence	1.02381689
67	MP0000613_abnormal_salivary_gland	1.01033316
68	MP0000689_abnormal_spleen_morphology	1.00850063
69	MP0003718_maternal_effect	1.00510764
70	MP0000716_abnormal_immune_system	1.00039255
71	MP0001845_abnormal_inflammatory_respons	0.99607879
72	MP0006036_abnormal_mitochondrial_physio	0.97214106
73	MP0003436_decreased_susceptibility_to	0.97148131
74	MP0001529_abnormal_vocalization	0.95433290
75	MP0002160_abnormal_reproductive_system	0.95058460
76	MP0003880_abnormal_central_pattern	0.94645276
77	MP0002398_abnormal_bone_marrow	0.92566123
78	MP0005085_abnormal_gallbladder_physiolo	0.92190834
79	MP0005167_abnormal_blood-brain_barrier	0.90967675
80	MP0005636_abnormal_mineral_homeostasis	0.90636453
81	MP0005365_abnormal_bile_salt	0.90556394
82	MP0001501_abnormal_sleep_pattern	0.89412483
83	MP0006276_abnormal_autonomic_nervous	0.87302608
84	MP0001119_abnormal_female_reproductive	0.85815962
85	MP0005332_abnormal_amino_acid	0.85783375
86	MP0002938_white_spotting	0.85418557
87	MP0002722_abnormal_immune_system	0.84444213
88	MP0000647_abnormal_sebaceous_gland	0.84285073
89	MP0010155_abnormal_intestine_physiology	0.84182454
90	MP0002405_respiratory_system_inflammati	0.81892905
91	MP0002272_abnormal_nervous_system	0.81540302
92	MP0002693_abnormal_pancreas_physiology	0.80625716
93	MP0008469_abnormal_protein_level	0.79840526
94	MP0002638_abnormal_pupillary_reflex	0.78759528
95	MP0003186_abnormal_redox_activity	0.77192427
96	MP0000703_abnormal_thymus_morphology	0.76644217
97	MP0001765_abnormal_ion_homeostasis	0.75803427
98	MP0002429_abnormal_blood_cell	0.75117055
99	MP0000465_gastrointestinal_hemorrhage	0.74387528
100	MP0001929_abnormal_gametogenesis	0.73449249

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	3.93181457
2	Acute necrotizing encephalopathy (HP:0006965)	3.92569587
3	Mitochondrial inheritance (HP:0001427)	3.73254870
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.53506843
5	Acute encephalopathy (HP:0006846)	3.46269584
6	Congenital stationary night blindness (HP:0007642)	3.34769724
7	Increased CSF lactate (HP:0002490)	3.32477830
8	Progressive macrocephaly (HP:0004481)	3.31680624
9	Pancreatic cysts (HP:0001737)	3.30783279
10	Abnormality of alanine metabolism (HP:0010916)	3.26413797
11	Hyperalaninemia (HP:0003348)	3.26413797
12	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.26413797
13	3-Methylglutaconic aciduria (HP:0003535)	3.12244366
14	Hepatocellular necrosis (HP:0001404)	3.06892416
15	Methylmalonic acidemia (HP:0002912)	3.06495864
16	Increased hepatocellular lipid droplets (HP:0006565)	3.06368611
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.04914220
18	Lipid accumulation in hepatocytes (HP:0006561)	3.03910634
19	Abnormality of the renal cortex (HP:0011035)	2.95730083
20	Elevated erythrocyte sedimentation rate (HP:0003565)	2.95669060
21	Hepatic necrosis (HP:0002605)	2.91821826
22	Renal cortical cysts (HP:0000803)	2.86456395
23	Pancreatic fibrosis (HP:0100732)	2.82766208
24	Aplastic anemia (HP:0001915)	2.79935432
25	Severe combined immunodeficiency (HP:0004430)	2.79133729
26	Attenuation of retinal blood vessels (HP:0007843)	2.77494988
27	True hermaphroditism (HP:0010459)	2.76641131
28	Stomatitis (HP:0010280)	2.73102394
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.72721328
30	Congenital, generalized hypertrichosis (HP:0004540)	2.68766959
31	Hypoproteinemia (HP:0003075)	2.67712204
32	Abolished electroretinogram (ERG) (HP:0000550)	2.62762596
33	Methylmalonic aciduria (HP:0012120)	2.59292852
34	Cerebral edema (HP:0002181)	2.56902545
35	Optic disc pallor (HP:0000543)	2.50630525
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.47315609
37	Increased serum lactate (HP:0002151)	2.46197974
38	Abnormality of T cell number (HP:0011839)	2.42341121
39	Constricted visual fields (HP:0001133)	2.41854814
40	Renal Fanconi syndrome (HP:0001994)	2.39991669
41	Abnormality of the prostate (HP:0008775)	2.39269092
42	Lactic acidosis (HP:0003128)	2.39252184
43	Increased intramyocellular lipid droplets (HP:0012240)	2.35180638
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.34982992
45	T lymphocytopenia (HP:0005403)	2.32172028
46	Abnormality of the pons (HP:0007361)	2.31883806
47	Molar tooth sign on MRI (HP:0002419)	2.31851420
48	Abnormality of midbrain morphology (HP:0002418)	2.31851420
49	Abnormality of T cells (HP:0002843)	2.28138257
50	Prostate neoplasm (HP:0100787)	2.25925162
51	Thyroiditis (HP:0100646)	2.24759348
52	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.24676611
53	Increased IgM level (HP:0003496)	2.22998136
54	Abnormal number of erythroid precursors (HP:0012131)	2.20680828
55	Hypoplasia of the pons (HP:0012110)	2.20370759
56	Abnormality of B cell number (HP:0010975)	2.20021303
57	Pancytopenia (HP:0001876)	2.19836638
58	Aplasia/hypoplasia of the uterus (HP:0008684)	2.18200908
59	Nephronophthisis (HP:0000090)	2.16290460
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.16015951
61	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.16015951
62	Decreased central vision (HP:0007663)	2.14676669
63	Abnormality of serum amino acid levels (HP:0003112)	2.10732414
64	Type II lissencephaly (HP:0007260)	2.07042186
65	Absent thumb (HP:0009777)	2.06760411
66	Exertional dyspnea (HP:0002875)	2.06696477
67	Type I transferrin isoform profile (HP:0003642)	2.06348321
68	Lethargy (HP:0001254)	2.04852123
69	Combined immunodeficiency (HP:0005387)	2.04344712
70	Abnormality of eosinophils (HP:0001879)	2.04109522
71	Abnormality of T cell physiology (HP:0011840)	2.03449100
72	Increased muscle lipid content (HP:0009058)	2.02997300
73	Pendular nystagmus (HP:0012043)	2.01473481
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.00999359
75	Sclerocornea (HP:0000647)	1.98417689
76	Short tibia (HP:0005736)	1.97509817
77	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.96363901
78	Dicarboxylic aciduria (HP:0003215)	1.96363901
79	Polydipsia (HP:0001959)	1.95949612
80	Abnormal drinking behavior (HP:0030082)	1.95949612
81	Respiratory failure (HP:0002878)	1.95827496
82	Abnormality of the renal medulla (HP:0100957)	1.94369133
83	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94136776
84	Stomach cancer (HP:0012126)	1.94007808
85	Hypoplasia of the uterus (HP:0000013)	1.93986636
86	Type 2 muscle fiber atrophy (HP:0003554)	1.93970713
87	Glycosuria (HP:0003076)	1.92906546
88	Abnormality of urine glucose concentration (HP:0011016)	1.92906546
89	Oral leukoplakia (HP:0002745)	1.92647056
90	Bile duct proliferation (HP:0001408)	1.92402061
91	Abnormal biliary tract physiology (HP:0012439)	1.92402061
92	Generalized aminoaciduria (HP:0002909)	1.90503543
93	Hyperglycinemia (HP:0002154)	1.85596857
94	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.85302973
95	Increased corneal curvature (HP:0100692)	1.82723119
96	Keratoconus (HP:0000563)	1.82723119
97	Abnormality of vitamin B metabolism (HP:0004340)	1.80555175
98	Medial flaring of the eyebrow (HP:0010747)	1.80394145
99	B lymphocytopenia (HP:0010976)	1.78974422
100	Panhypogammaglobulinemia (HP:0003139)	1.78927312

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.16436184
2	ZAK	3.88288986
3	TXK	3.71735822
4	VRK2	3.12140737
5	MAP4K2	2.88040580
6	TAOK3	2.61151082
7	NUAK1	2.50231848
8	BUB1	2.47516296
9	VRK1	2.32417025
10	KDR	2.29593104
11	ADRBK2	2.27119295
12	TESK2	2.12969989
13	BCKDK	1.99426659
14	MST4	1.96393688
15	GRK1	1.89593952
16	PASK	1.84534759
17	FRK	1.79177107
18	MAP3K12	1.70529317
19	CDK19	1.62030373
20	STK16	1.57751095
21	PINK1	1.53043159
22	MUSK	1.48053224
23	FES	1.30757200
24	GRK6	1.29483229
25	MAP4K1	1.25408373
26	WNK3	1.24277984
27	ITK	1.21450184
28	LIMK1	1.17096879
29	WNK4	1.16543112
30	EIF2AK3	1.14897534
31	INSRR	1.14486908
32	IKBKB	1.11785270
33	TEC	1.10431262
34	RPS6KA5	1.06929744
35	TRIM28	1.05836296
36	SCYL2	1.03844157
37	NEK1	1.00666215
38	CSNK1G3	0.97027302
39	SYK	0.94736665
40	TIE1	0.94269034
41	OXSR1	0.93625476
42	NME1	0.92624245
43	LMTK2	0.91897526
44	IKBKE	0.90575949
45	KIT	0.89971905
46	BMPR2	0.89543228
47	DAPK1	0.88556499
48	ERBB3	0.85516819
49	MAP2K2	0.83114918
50	CSNK1G2	0.78922499
51	MYLK	0.78059676
52	CAMKK2	0.76021558
53	TSSK6	0.75860334
54	CSNK1G1	0.73271368
55	CSNK1A1L	0.72439144
56	BMPR1B	0.70037922
57	EIF2AK2	0.68412118
58	PRKCQ	0.67062328
59	SRPK1	0.64788529
60	TAF1	0.64604802
61	LCK	0.63184337
62	PLK3	0.62414765
63	PHKG2	0.60658379
64	PHKG1	0.60658379
65	RPS6KA4	0.59489462
66	LYN	0.59242481
67	DYRK2	0.57662867
68	ADRBK1	0.54875953
69	MAP2K7	0.53724735
70	TRPM7	0.53406048
71	BCR	0.52946278
72	CSF1R	0.52756997
73	STK39	0.52545745
74	BTK	0.51904100
75	MAPKAPK3	0.50949548
76	IGF1R	0.49384019
77	PLK4	0.47860450
78	MAP3K14	0.47201560
79	DAPK3	0.46456064
80	TESK1	0.45462756
81	PIM1	0.44128252
82	TBK1	0.43976926
83	GRK7	0.43584968
84	AURKA	0.41920300
85	AURKB	0.40716977
86	FLT3	0.38845056
87	PRKCE	0.38200085
88	GRK5	0.36411083
89	PLK1	0.36333703
90	CSNK2A1	0.36181282
91	ZAP70	0.36141285
92	ATR	0.35811411
93	MAP3K4	0.33840493
94	PIK3CG	0.32757328
95	CDK8	0.32395754
96	MKNK1	0.31461388
97	MAP2K6	0.30883705
98	CSNK1A1	0.29782030
99	ACVR1B	0.29238189
100	PTK2B	0.28341560

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.04419767
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.27512301
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.95305769
4	Ribosome_Homo sapiens_hsa03010	2.95032277
5	Parkinsons disease_Homo sapiens_hsa05012	2.59357489
6	Asthma_Homo sapiens_hsa05310	2.37089360
7	Allograft rejection_Homo sapiens_hsa05330	2.35237907
8	Protein export_Homo sapiens_hsa03060	2.31823208
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.25817136
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.22306395
11	Graft-versus-host disease_Homo sapiens_hsa05332	2.20945166
12	RNA polymerase_Homo sapiens_hsa03020	2.10312349
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.00949209
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93863787
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.86708801
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.85292671
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.71698231
18	Alzheimers disease_Homo sapiens_hsa05010	1.63316028
19	Huntingtons disease_Homo sapiens_hsa05016	1.62002680
20	RNA degradation_Homo sapiens_hsa03018	1.61284157
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.60091163
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.58553004
23	One carbon pool by folate_Homo sapiens_hsa00670	1.57908542
24	Phototransduction_Homo sapiens_hsa04744	1.50309140
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49820949
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.46289581
27	Homologous recombination_Homo sapiens_hsa03440	1.46051386
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39844463
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.38780567
30	Basal transcription factors_Homo sapiens_hsa03022	1.33391665
31	Mismatch repair_Homo sapiens_hsa03430	1.26947796
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23258549
33	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23121987
34	Sulfur metabolism_Homo sapiens_hsa00920	1.22846353
35	Spliceosome_Homo sapiens_hsa03040	1.22543276
36	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.21878257
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.20903228
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.17185022
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16159962
40	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.14179956
41	Propanoate metabolism_Homo sapiens_hsa00640	1.13112096
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.12154125
43	Peroxisome_Homo sapiens_hsa04146	1.10945251
44	Caffeine metabolism_Homo sapiens_hsa00232	1.10342875
45	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08013909
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06349453
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01427985
48	DNA replication_Homo sapiens_hsa03030	0.99331529
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.98079481
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.97431813
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94419256
52	Base excision repair_Homo sapiens_hsa03410	0.92246258
53	Purine metabolism_Homo sapiens_hsa00230	0.90795014
54	Butanoate metabolism_Homo sapiens_hsa00650	0.88081130
55	RNA transport_Homo sapiens_hsa03013	0.87517855
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83406050
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.82989069
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80757984
59	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.78313916
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.75031413
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73238831
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73170883
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71563271
64	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69462976
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.69174461
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.69015172
67	Non-homologous end-joining_Homo sapiens_hsa03450	0.67825917
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66812562
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66178174
70	Retinol metabolism_Homo sapiens_hsa00830	0.65987335
71	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.65949969
72	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.65939580
73	Regulation of autophagy_Homo sapiens_hsa04140	0.63700368
74	Viral myocarditis_Homo sapiens_hsa05416	0.62482233
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59088641
76	Metabolic pathways_Homo sapiens_hsa01100	0.58664400
77	Glutathione metabolism_Homo sapiens_hsa00480	0.58458933
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56592567
79	Sulfur relay system_Homo sapiens_hsa04122	0.56076126
80	Alcoholism_Homo sapiens_hsa05034	0.53410626
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52712168
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.49858480
83	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49375859
84	Fatty acid elongation_Homo sapiens_hsa00062	0.46284816
85	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.44962160
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41579189
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41544666
88	Olfactory transduction_Homo sapiens_hsa04740	0.40997995
89	Taste transduction_Homo sapiens_hsa04742	0.39297647
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.33908887
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32319023
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32015967
93	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.31175801
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31038933
95	Herpes simplex infection_Homo sapiens_hsa05168	0.30405955
96	Nicotine addiction_Homo sapiens_hsa05033	0.30004035
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27670159
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.25937279
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.24415161
100	Legionellosis_Homo sapiens_hsa05134	0.23344488

EEF1A1P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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