ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.73964408
2	cytidine metabolic process (GO:0046087)	4.37301509
3	cytidine catabolic process (GO:0006216)	4.37301509
4	cytidine deamination (GO:0009972)	4.37301509
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.31564334
6	ATP synthesis coupled proton transport (GO:0015986)	4.31564334
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.26884104
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.21233721
9	water-soluble vitamin biosynthetic process (GO:0042364)	3.83323829
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.75420509
11	platelet dense granule organization (GO:0060155)	3.64869601
12	respiratory chain complex IV assembly (GO:0008535)	3.60788506
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.46524512
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.42610516
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.42610516
16	response to pheromone (GO:0019236)	3.40841781
17	L-fucose catabolic process (GO:0042355)	3.39330473
18	fucose catabolic process (GO:0019317)	3.39330473
19	L-fucose metabolic process (GO:0042354)	3.39330473
20	ribosomal small subunit assembly (GO:0000028)	3.38580957
21	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.28279213
22	protein neddylation (GO:0045116)	3.21112678
23	protein complex biogenesis (GO:0070271)	3.17312357
24	electron transport chain (GO:0022900)	3.14824071
25	respiratory electron transport chain (GO:0022904)	3.13832139
26	proteasome assembly (GO:0043248)	3.10149965
27	cytochrome complex assembly (GO:0017004)	3.09647793
28	positive regulation of defense response to virus by host (GO:0002230)	3.07695670
29	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.02480303
30	regulation of regulatory T cell differentiation (GO:0045589)	2.97234180
31	negative regulation of telomere maintenance (GO:0032205)	2.96748874
32	GTP biosynthetic process (GO:0006183)	2.92394324
33	positive regulation of prostaglandin secretion (GO:0032308)	2.90090033
34	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89616785
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89584043
36	regulation of isotype switching to IgG isotypes (GO:0048302)	2.88837617
37	regulation of cellular amino acid metabolic process (GO:0006521)	2.87591019
38	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.84354109
39	behavioral response to nicotine (GO:0035095)	2.84179594
40	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.81201880
41	termination of RNA polymerase III transcription (GO:0006386)	2.81201880
42	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.76816158
43	mannosylation (GO:0097502)	2.76785734
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.74169776
45	NADH dehydrogenase complex assembly (GO:0010257)	2.74169776
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.74169776
47	chaperone-mediated protein transport (GO:0072321)	2.70604424
48	cellular ketone body metabolic process (GO:0046950)	2.66186715
49	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.66138049
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.66080694
51	pseudouridine synthesis (GO:0001522)	2.64982745
52	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.64734076
53	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.64283125
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.61997372
55	GPI anchor metabolic process (GO:0006505)	2.61042734
56	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.59391980
57	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.58110193
58	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.58110193
59	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.58110193
60	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.57956294
61	cellular response to interleukin-15 (GO:0071350)	2.57107246
62	proton transport (GO:0015992)	2.56060785
63	ATP biosynthetic process (GO:0006754)	2.55999261
64	cullin deneddylation (GO:0010388)	2.55769037
65	sulfation (GO:0051923)	2.54189917
66	GPI anchor biosynthetic process (GO:0006506)	2.53669808
67	piRNA metabolic process (GO:0034587)	2.53538732
68	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.52144619
69	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.52144619
70	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.51549458
71	hydrogen transport (GO:0006818)	2.51429070
72	hydrogen ion transmembrane transport (GO:1902600)	2.50390315
73	regulation of chronic inflammatory response (GO:0002676)	2.50323789
74	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.49832394
75	iron-sulfur cluster assembly (GO:0016226)	2.43863837
76	metallo-sulfur cluster assembly (GO:0031163)	2.43863837
77	regulation of T cell mediated cytotoxicity (GO:0001914)	2.43406514
78	response to interferon-beta (GO:0035456)	2.43204504
79	protein deneddylation (GO:0000338)	2.43196439
80	positive regulation of respiratory burst (GO:0060267)	2.43137327
81	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.41176689
82	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.41176689
83	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.40736534
84	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.38809921
85	peptidyl-histidine modification (GO:0018202)	2.38710471
86	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.38247198
87	rRNA modification (GO:0000154)	2.37785865
88	aldehyde catabolic process (GO:0046185)	2.37619387
89	vitamin biosynthetic process (GO:0009110)	2.37280503
90	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.36751277
91	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.36640666
92	regulation of mitotic spindle checkpoint (GO:1903504)	2.36640666
93	ketone body metabolic process (GO:1902224)	2.36517203
94	regulation of T cell receptor signaling pathway (GO:0050856)	2.36158878
95	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.35367981
96	positive regulation of T-helper 1 type immune response (GO:0002827)	2.34404734
97	nucleotide transmembrane transport (GO:1901679)	2.34255122
98	UTP metabolic process (GO:0046051)	2.33305723
99	regulation of immunoglobulin secretion (GO:0051023)	2.32940715
100	positive regulation of fatty acid transport (GO:2000193)	2.32082073

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.87141906
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.75000518
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.17665248
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.09523930
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.07339809
6	VDR_22108803_ChIP-Seq_LS180_Human	3.05035783
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.95655227
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78942696
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.78662108
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.78148092
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.76796441
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.59340196
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54343025
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.52426277
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.28546035
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.26014921
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.22322280
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12825646
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.03040437
20	ELK1_19687146_ChIP-ChIP_HELA_Human	2.00457059
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.98960517
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97589261
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93276552
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.91790048
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.84258561
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.83049260
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76754234
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.75239940
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.71434482
30	EWS_26573619_Chip-Seq_HEK293_Human	1.70818772
31	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.67712483
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.65230408
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.57915397
34	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.57915397
35	AR_20517297_ChIP-Seq_VCAP_Human	1.54598218
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53645308
37	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.51332408
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49833899
39	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.49804544
40	GATA3_26560356_Chip-Seq_TH2_Human	1.48382316
41	FUS_26573619_Chip-Seq_HEK293_Human	1.47037336
42	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.45732706
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.43981893
44	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.38723785
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36857150
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36857150
47	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.30705172
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.30326275
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30088010
50	P300_19829295_ChIP-Seq_ESCs_Human	1.28988365
51	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28089964
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27514790
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27179553
54	NCOR_22424771_ChIP-Seq_293T_Human	1.23856292
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.23775454
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20874779
57	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.20126927
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19894906
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19667361
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.18621215
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17343745
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.16318063
63	MYB_26560356_Chip-Seq_TH2_Human	1.15689877
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14929246
65	ER_23166858_ChIP-Seq_MCF-7_Human	1.14310919
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.13349292
67	TAF15_26573619_Chip-Seq_HEK293_Human	1.12608744
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12365985
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.11785102
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11394014
71	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.10961871
72	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.10125840
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09087865
74	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07918114
75	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06854649
76	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.06491988
77	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04573218
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03706382
79	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03006522
80	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.02944339
81	TAF2_19829295_ChIP-Seq_ESCs_Human	1.02262514
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02245075
83	CBP_20019798_ChIP-Seq_JUKART_Human	1.01846956
84	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01846956
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00309284
86	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00284756
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.99548806
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.98559623
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.98213837
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97813421
91	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96123988
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.95862803
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95685853
94	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.95185197
95	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95000884
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94298594
97	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94041803
98	TTF2_22483619_ChIP-Seq_HELA_Human	0.92732550
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.92415192
100	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.91454842

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.74935280
2	MP0001835_abnormal_antigen_presentation	3.05287464
3	MP0005360_urolithiasis	2.90659672
4	MP0004147_increased_porphyrin_level	2.66367363
5	MP0002102_abnormal_ear_morphology	2.47267740
6	MP0006072_abnormal_retinal_apoptosis	2.44271645
7	MP0003195_calcinosis	2.34634313
8	MP0008877_abnormal_DNA_methylation	2.28858921
9	MP0005645_abnormal_hypothalamus_physiol	2.24495295
10	MP0002166_altered_tumor_susceptibility	2.05347885
11	MP0008872_abnormal_physiological_respon	2.03151821
12	MP0009785_altered_susceptibility_to	2.02663034
13	MP0002138_abnormal_hepatobiliary_system	2.00385316
14	MP0009379_abnormal_foot_pigmentation	1.93842389
15	MP0005085_abnormal_gallbladder_physiolo	1.92404126
16	MP0008875_abnormal_xenobiotic_pharmacok	1.90056496
17	MP0002148_abnormal_hypersensitivity_rea	1.86574881
18	MP0000685_abnormal_immune_system	1.80687234
19	MP0002876_abnormal_thyroid_physiology	1.79405488
20	MP0003806_abnormal_nucleotide_metabolis	1.78458003
21	MP0001873_stomach_inflammation	1.77750955
22	MP0001800_abnormal_humoral_immune	1.75569660
23	MP0002006_tumorigenesis	1.75182436
24	MP0002837_dystrophic_cardiac_calcinosis	1.74837504
25	MP0001790_abnormal_immune_system	1.73797088
26	MP0005387_immune_system_phenotype	1.73797088
27	MP0010155_abnormal_intestine_physiology	1.70537805
28	MP0002139_abnormal_hepatobiliary_system	1.62774887
29	MP0003011_delayed_dark_adaptation	1.60055840
30	MP0005084_abnormal_gallbladder_morpholo	1.59680417
31	MP0003724_increased_susceptibility_to	1.57040272
32	MP0005000_abnormal_immune_tolerance	1.56607729
33	MP0003866_abnormal_defecation	1.55537049
34	MP0005075_abnormal_melanosome_morpholog	1.55042565
35	MP0005551_abnormal_eye_electrophysiolog	1.54938974
36	MP0001986_abnormal_taste_sensitivity	1.49543477
37	MP0004019_abnormal_vitamin_homeostasis	1.48855961
38	MP0002277_abnormal_respiratory_mucosa	1.45665865
39	MP0001764_abnormal_homeostasis	1.44431421
40	MP0002723_abnormal_immune_serum	1.42782596
41	MP0003787_abnormal_imprinting	1.42314551
42	MP0003786_premature_aging	1.40220423
43	MP0009333_abnormal_splenocyte_physiolog	1.39071020
44	MP0005332_abnormal_amino_acid	1.38864076
45	MP0001666_abnormal_nutrient_absorption	1.36952482
46	MP0005253_abnormal_eye_physiology	1.36648770
47	MP0006292_abnormal_olfactory_placode	1.34858376
48	MP0002163_abnormal_gland_morphology	1.33510769
49	MP0003763_abnormal_thymus_physiology	1.33483070
50	MP0004885_abnormal_endolymph	1.33289338
51	MP0003718_maternal_effect	1.30904319
52	MP0000372_irregular_coat_pigmentation	1.30500132
53	MP0009764_decreased_sensitivity_to	1.28594415
54	MP0002420_abnormal_adaptive_immunity	1.27365584
55	MP0001819_abnormal_immune_cell	1.26842440
56	MP0001968_abnormal_touch/_nociception	1.24722068
57	MP0005365_abnormal_bile_salt	1.23089121
58	MP0002452_abnormal_antigen_presenting	1.22991279
59	MP0003252_abnormal_bile_duct	1.20212981
60	MP0001501_abnormal_sleep_pattern	1.17715317
61	MP0001845_abnormal_inflammatory_respons	1.15798982
62	MP0003878_abnormal_ear_physiology	1.14575265
63	MP0005377_hearing/vestibular/ear_phenot	1.14575265
64	MP0006036_abnormal_mitochondrial_physio	1.13936594
65	MP0005636_abnormal_mineral_homeostasis	1.12362748
66	MP0005025_abnormal_response_to	1.11978860
67	MP0005646_abnormal_pituitary_gland	1.10965984
68	MP0002736_abnormal_nociception_after	1.08623999
69	MP0005379_endocrine/exocrine_gland_phen	1.08473152
70	MP0002693_abnormal_pancreas_physiology	1.04534269
71	MP0008058_abnormal_DNA_repair	1.04404872
72	MP0004142_abnormal_muscle_tone	1.02683880
73	MP0003693_abnormal_embryo_hatching	0.99870978
74	MP0004145_abnormal_muscle_electrophysio	0.98982308
75	MP0001765_abnormal_ion_homeostasis	0.98903427
76	MP0005410_abnormal_fertilization	0.98165065
77	MP0001919_abnormal_reproductive_system	0.97705865
78	MP0003646_muscle_fatigue	0.97640184
79	MP0001485_abnormal_pinna_reflex	0.97155689
80	MP0006082_CNS_inflammation	0.97047946
81	MP0005389_reproductive_system_phenotype	0.96189561
82	MP0002638_abnormal_pupillary_reflex	0.93634360
83	MP0009643_abnormal_urine_homeostasis	0.91324912
84	MP0008469_abnormal_protein_level	0.90354822
85	MP0010329_abnormal_lipoprotein_level	0.89077864
86	MP0001188_hyperpigmentation	0.88620275
87	MP0000689_abnormal_spleen_morphology	0.87011141
88	MP0001905_abnormal_dopamine_level	0.86454600
89	MP0000716_abnormal_immune_system	0.86231100
90	MP0003186_abnormal_redox_activity	0.86158370
91	MP0010386_abnormal_urinary_bladder	0.85797150
92	MP0002938_white_spotting	0.85664626
93	MP0002254_reproductive_system_inflammat	0.84694167
94	MP0002272_abnormal_nervous_system	0.82710964
95	MP0000013_abnormal_adipose_tissue	0.79490912
96	MP0002398_abnormal_bone_marrow	0.79384832
97	MP0008775_abnormal_heart_ventricle	0.76672969
98	MP0003283_abnormal_digestive_organ	0.75269832
99	MP0003638_abnormal_response/metabolism_	0.75225683
100	MP0001663_abnormal_digestive_system	0.70661573

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.63127122
2	IgG deficiency (HP:0004315)	3.59068621
3	Mitochondrial inheritance (HP:0001427)	3.51945303
4	Acute encephalopathy (HP:0006846)	3.25253152
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.24909930
6	Increased CSF lactate (HP:0002490)	3.23372456
7	Abolished electroretinogram (ERG) (HP:0000550)	3.14867552
8	Increased hepatocellular lipid droplets (HP:0006565)	3.14371597
9	Progressive macrocephaly (HP:0004481)	3.13485174
10	Lipid accumulation in hepatocytes (HP:0006561)	3.11497975
11	Stomatitis (HP:0010280)	3.09338255
12	Pancreatic cysts (HP:0001737)	3.03208336
13	Hepatocellular necrosis (HP:0001404)	2.99283590
14	Congenital stationary night blindness (HP:0007642)	2.99248665
15	Hepatic necrosis (HP:0002605)	2.95726866
16	Type II lissencephaly (HP:0007260)	2.92834521
17	3-Methylglutaconic aciduria (HP:0003535)	2.91051080
18	Elevated erythrocyte sedimentation rate (HP:0003565)	2.77453343
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.74038421
20	Abnormality of the renal cortex (HP:0011035)	2.72042007
21	Abnormality of midbrain morphology (HP:0002418)	2.67935956
22	Molar tooth sign on MRI (HP:0002419)	2.67935956
23	Methylmalonic acidemia (HP:0002912)	2.65466223
24	Abnormality of the pons (HP:0007361)	2.65249501
25	Congenital, generalized hypertrichosis (HP:0004540)	2.64933459
26	Pancreatic fibrosis (HP:0100732)	2.64315844
27	Glycosuria (HP:0003076)	2.64314725
28	Abnormality of urine glucose concentration (HP:0011016)	2.64314725
29	Hypoproteinemia (HP:0003075)	2.63536458
30	Cerebral edema (HP:0002181)	2.59929042
31	Severe combined immunodeficiency (HP:0004430)	2.55648260
32	Renal Fanconi syndrome (HP:0001994)	2.54534732
33	Chronic diarrhea (HP:0002028)	2.53744454
34	Hypoplasia of the pons (HP:0012110)	2.53554738
35	Methylmalonic aciduria (HP:0012120)	2.50824492
36	Renal cortical cysts (HP:0000803)	2.50594429
37	True hermaphroditism (HP:0010459)	2.49224583
38	Abnormality of vitamin B metabolism (HP:0004340)	2.44667229
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.44347160
40	Thyroiditis (HP:0100646)	2.40759633
41	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.40517384
42	Increased serum lactate (HP:0002151)	2.39526007
43	Lethargy (HP:0001254)	2.38818375
44	Lactic acidosis (HP:0003128)	2.31812268
45	Optic disc pallor (HP:0000543)	2.31197022
46	Nephronophthisis (HP:0000090)	2.29840630
47	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.29651448
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.29408766
49	Increased intramyocellular lipid droplets (HP:0012240)	2.27737523
50	Aplastic anemia (HP:0001915)	2.26943782
51	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.26378736
52	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.26378736
53	Exertional dyspnea (HP:0002875)	2.20684502
54	Increased IgM level (HP:0003496)	2.19768282
55	Dicarboxylic aciduria (HP:0003215)	2.15991420
56	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.15991420
57	Abnormality of the prostate (HP:0008775)	2.15717136
58	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14591849
59	Hyperglycinuria (HP:0003108)	2.14362453
60	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.13796879
61	Hypothermia (HP:0002045)	2.12693329
62	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.12594129
63	Abnormality of T cell number (HP:0011839)	2.09514161
64	Type I transferrin isoform profile (HP:0003642)	2.08567135
65	Attenuation of retinal blood vessels (HP:0007843)	2.07262352
66	Abnormality of T cells (HP:0002843)	2.05342611
67	Bile duct proliferation (HP:0001408)	2.04895469
68	Abnormal biliary tract physiology (HP:0012439)	2.04895469
69	Abnormality of the renal medulla (HP:0100957)	2.04216196
70	T lymphocytopenia (HP:0005403)	2.02564711
71	Increased muscle lipid content (HP:0009058)	2.00835285
72	Hypoalbuminemia (HP:0003073)	2.00346414
73	Abnormal albumin level (HP:0012116)	2.00346414
74	Abnormal drinking behavior (HP:0030082)	1.99670934
75	Polydipsia (HP:0001959)	1.99670934
76	Abnormality of glycine metabolism (HP:0010895)	1.99496396
77	Abnormality of serine family amino acid metabolism (HP:0010894)	1.99496396
78	Tongue fasciculations (HP:0001308)	1.98747384
79	Hypomagnesemia (HP:0002917)	1.95521060
80	Respiratory failure (HP:0002878)	1.94874986
81	Panhypogammaglobulinemia (HP:0003139)	1.93948799
82	Medial flaring of the eyebrow (HP:0010747)	1.92692952
83	Aplasia/hypoplasia of the uterus (HP:0008684)	1.92363913
84	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89733790
85	Abnormality of magnesium homeostasis (HP:0004921)	1.89450480
86	Cerebellar dysplasia (HP:0007033)	1.89071638
87	Abnormality of eosinophils (HP:0001879)	1.88691224
88	Combined immunodeficiency (HP:0005387)	1.85536902
89	Abnormality of alanine metabolism (HP:0010916)	1.84415951
90	Hyperalaninemia (HP:0003348)	1.84415951
91	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84415951
92	Absent/shortened dynein arms (HP:0200106)	1.83340764
93	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.83340764
94	Generalized aminoaciduria (HP:0002909)	1.82007851
95	Hyperphosphaturia (HP:0003109)	1.80705630
96	Asplenia (HP:0001746)	1.80109464
97	Reticulocytopenia (HP:0001896)	1.78738864
98	Abnormality of B cell number (HP:0010975)	1.78490683
99	Colon cancer (HP:0003003)	1.77682166
100	Abnormality of T cell physiology (HP:0011840)	1.77457446

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.61235679
2	ZAK	3.23787211
3	MAP4K2	2.82077491
4	TAOK3	2.79677785
5	MST4	2.78172968
6	NUAK1	2.77370133
7	TLK1	2.68705950
8	VRK2	2.66560258
9	ADRBK2	2.62503726
10	FRK	2.47440174
11	GRK1	2.16085926
12	STK16	1.90681385
13	PASK	1.87134871
14	TIE1	1.81230144
15	VRK1	1.78520778
16	MAP4K1	1.74364396
17	CDK19	1.71752315
18	EIF2AK3	1.69317566
19	MAP3K12	1.65286876
20	WNK3	1.61607916
21	ACVR1B	1.61347373
22	BCKDK	1.57748904
23	TEC	1.48485616
24	BMPR1B	1.48325590
25	OXSR1	1.45635959
26	TSSK6	1.45600519
27	KDR	1.35624556
28	WNK4	1.31938731
29	TRIM28	1.21648744
30	INSRR	1.21342277
31	ITK	1.19502393
32	IKBKB	1.15693394
33	KIT	1.13957193
34	STK39	1.12312120
35	PINK1	1.10038195
36	TAF1	1.04873029
37	BUB1	1.02900606
38	FES	1.02640091
39	NME1	0.98585594
40	TESK2	0.98481967
41	NLK	0.98366278
42	PLK3	0.97788698
43	MYLK	0.91833324
44	IKBKE	0.89517271
45	CSNK1G3	0.89184284
46	MAP2K6	0.86919600
47	NEK1	0.85777606
48	DAPK1	0.83587130
49	CSNK1G1	0.83399180
50	GRK6	0.80600604
51	PRKCQ	0.80548885
52	MUSK	0.79536011
53	SYK	0.78565953
54	DAPK2	0.74033629
55	CSNK1G2	0.73904972
56	DYRK2	0.73741718
57	ERBB3	0.73273747
58	PHKG1	0.72396218
59	PHKG2	0.72396218
60	PRKCE	0.71660452
61	TGFBR1	0.70180838
62	RPS6KA5	0.69037377
63	BMPR2	0.68050659
64	SRPK1	0.67866991
65	TNIK	0.61222603
66	LCK	0.61036509
67	EIF2AK2	0.60992871
68	MAP2K2	0.60284936
69	MKNK1	0.59079698
70	MAP3K14	0.57707060
71	MKNK2	0.56577671
72	LYN	0.56427764
73	PLK4	0.55924611
74	FLT3	0.52848412
75	MATK	0.51273324
76	PIM1	0.50408327
77	ADRBK1	0.49749319
78	JAK3	0.47610894
79	MAPK13	0.46485758
80	LIMK1	0.45487730
81	CSNK1A1L	0.45472762
82	IRAK1	0.43383101
83	CSF1R	0.42623453
84	IGF1R	0.42014656
85	BTK	0.41805410
86	MARK3	0.40585138
87	PRKCA	0.40081731
88	RPS6KA4	0.39735481
89	BRSK2	0.37903585
90	PLK2	0.37650447
91	CAMKK2	0.36997727
92	CSNK1A1	0.36867353
93	GRK5	0.36774074
94	GRK7	0.36770073
95	BCR	0.36290125
96	PAK3	0.36064664
97	CSNK2A2	0.35499729
98	PTK2B	0.35151894
99	EIF2AK1	0.34787076
100	PRKCG	0.33981291

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.33252308
2	Proteasome_Homo sapiens_hsa03050	3.14308788
3	Allograft rejection_Homo sapiens_hsa05330	2.97170849
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.84528176
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.82631778
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.79732953
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.66182381
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.62071936
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.48581975
10	Protein export_Homo sapiens_hsa03060	2.35984869
11	Parkinsons disease_Homo sapiens_hsa05012	2.25836410
12	Ribosome_Homo sapiens_hsa03010	2.21165464
13	RNA polymerase_Homo sapiens_hsa03020	1.90695221
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82980805
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.82219495
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80134379
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.74242715
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.62484697
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.59129097
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.58619418
21	Sulfur metabolism_Homo sapiens_hsa00920	1.57218302
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54861686
23	Caffeine metabolism_Homo sapiens_hsa00232	1.46215679
24	Propanoate metabolism_Homo sapiens_hsa00640	1.43759897
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.37632193
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35902102
27	Huntingtons disease_Homo sapiens_hsa05016	1.33264718
28	Alzheimers disease_Homo sapiens_hsa05010	1.33165669
29	Phototransduction_Homo sapiens_hsa04744	1.32911888
30	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.29826412
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.23581511
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.22729280
33	Butanoate metabolism_Homo sapiens_hsa00650	1.19777451
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.19215145
35	RNA degradation_Homo sapiens_hsa03018	1.18701461
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.16579377
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.16244283
38	Peroxisome_Homo sapiens_hsa04146	1.13329572
39	Homologous recombination_Homo sapiens_hsa03440	1.13293669
40	Basal transcription factors_Homo sapiens_hsa03022	1.13008247
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11498645
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.04460425
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.03007013
44	Ether lipid metabolism_Homo sapiens_hsa00565	1.01358492
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.95563233
46	Retinol metabolism_Homo sapiens_hsa00830	0.93020686
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92717086
48	One carbon pool by folate_Homo sapiens_hsa00670	0.90856747
49	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.88498392
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86269632
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85154459
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84747843
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84083579
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.83878699
55	Purine metabolism_Homo sapiens_hsa00230	0.79312498
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.75809555
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75130006
58	Viral myocarditis_Homo sapiens_hsa05416	0.72279845
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.71266896
60	Regulation of autophagy_Homo sapiens_hsa04140	0.71260980
61	Sulfur relay system_Homo sapiens_hsa04122	0.70101866
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69825455
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68213359
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67814806
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67041333
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66812611
67	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.66092517
68	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65369905
69	Glutathione metabolism_Homo sapiens_hsa00480	0.64111461
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63089145
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62432071
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.61287871
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60612021
74	Fatty acid degradation_Homo sapiens_hsa00071	0.60562946
75	Metabolic pathways_Homo sapiens_hsa01100	0.60094417
76	Fatty acid elongation_Homo sapiens_hsa00062	0.58822725
77	Mineral absorption_Homo sapiens_hsa04978	0.57343372
78	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.57223459
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.57066823
80	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.56244955
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55084481
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.53432586
83	RNA transport_Homo sapiens_hsa03013	0.53297705
84	Folate biosynthesis_Homo sapiens_hsa00790	0.53267602
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.52843536
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.52031463
87	Mismatch repair_Homo sapiens_hsa03430	0.51176217
88	Spliceosome_Homo sapiens_hsa03040	0.50652375
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50471805
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46614355
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44886978
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.42372617
93	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.40357303
94	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.37753985
95	Leishmaniasis_Homo sapiens_hsa05140	0.36733822
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35182540
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33785189
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.33552461
99	Renin-angiotensin system_Homo sapiens_hsa04614	0.33408058
100	Olfactory transduction_Homo sapiens_hsa04740	0.33382705

EEF1A1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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