EEF1A1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.73964408
2cytidine metabolic process (GO:0046087)4.37301509
3cytidine catabolic process (GO:0006216)4.37301509
4cytidine deamination (GO:0009972)4.37301509
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31564334
6ATP synthesis coupled proton transport (GO:0015986)4.31564334
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.26884104
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.21233721
9water-soluble vitamin biosynthetic process (GO:0042364)3.83323829
10pyrimidine ribonucleoside catabolic process (GO:0046133)3.75420509
11platelet dense granule organization (GO:0060155)3.64869601
12respiratory chain complex IV assembly (GO:0008535)3.60788506
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46524512
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42610516
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42610516
16response to pheromone (GO:0019236)3.40841781
17L-fucose catabolic process (GO:0042355)3.39330473
18fucose catabolic process (GO:0019317)3.39330473
19L-fucose metabolic process (GO:0042354)3.39330473
20ribosomal small subunit assembly (GO:0000028)3.38580957
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.28279213
22protein neddylation (GO:0045116)3.21112678
23protein complex biogenesis (GO:0070271)3.17312357
24electron transport chain (GO:0022900)3.14824071
25respiratory electron transport chain (GO:0022904)3.13832139
26proteasome assembly (GO:0043248)3.10149965
27cytochrome complex assembly (GO:0017004)3.09647793
28positive regulation of defense response to virus by host (GO:0002230)3.07695670
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02480303
30regulation of regulatory T cell differentiation (GO:0045589)2.97234180
31negative regulation of telomere maintenance (GO:0032205)2.96748874
32GTP biosynthetic process (GO:0006183)2.92394324
33positive regulation of prostaglandin secretion (GO:0032308)2.90090033
34mitochondrial respiratory chain complex assembly (GO:0033108)2.89616785
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89584043
36regulation of isotype switching to IgG isotypes (GO:0048302)2.88837617
37regulation of cellular amino acid metabolic process (GO:0006521)2.87591019
38positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.84354109
39behavioral response to nicotine (GO:0035095)2.84179594
40transcription elongation from RNA polymerase III promoter (GO:0006385)2.81201880
41termination of RNA polymerase III transcription (GO:0006386)2.81201880
42regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.76816158
43mannosylation (GO:0097502)2.76785734
44mitochondrial respiratory chain complex I assembly (GO:0032981)2.74169776
45NADH dehydrogenase complex assembly (GO:0010257)2.74169776
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.74169776
47chaperone-mediated protein transport (GO:0072321)2.70604424
48cellular ketone body metabolic process (GO:0046950)2.66186715
49positive regulation of T cell mediated cytotoxicity (GO:0001916)2.66138049
50purine nucleoside triphosphate biosynthetic process (GO:0009145)2.66080694
51pseudouridine synthesis (GO:0001522)2.64982745
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.64734076
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.64283125
54preassembly of GPI anchor in ER membrane (GO:0016254)2.61997372
55GPI anchor metabolic process (GO:0006505)2.61042734
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59391980
57signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.58110193
58signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.58110193
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.58110193
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.57956294
61cellular response to interleukin-15 (GO:0071350)2.57107246
62proton transport (GO:0015992)2.56060785
63ATP biosynthetic process (GO:0006754)2.55999261
64cullin deneddylation (GO:0010388)2.55769037
65sulfation (GO:0051923)2.54189917
66GPI anchor biosynthetic process (GO:0006506)2.53669808
67piRNA metabolic process (GO:0034587)2.53538732
68intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.52144619
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.52144619
70phosphatidylinositol acyl-chain remodeling (GO:0036149)2.51549458
71hydrogen transport (GO:0006818)2.51429070
72hydrogen ion transmembrane transport (GO:1902600)2.50390315
73regulation of chronic inflammatory response (GO:0002676)2.50323789
74positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.49832394
75iron-sulfur cluster assembly (GO:0016226)2.43863837
76metallo-sulfur cluster assembly (GO:0031163)2.43863837
77regulation of T cell mediated cytotoxicity (GO:0001914)2.43406514
78response to interferon-beta (GO:0035456)2.43204504
79protein deneddylation (GO:0000338)2.43196439
80positive regulation of respiratory burst (GO:0060267)2.43137327
81signal transduction involved in DNA damage checkpoint (GO:0072422)2.41176689
82signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41176689
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.40736534
84pyrimidine ribonucleoside metabolic process (GO:0046131)2.38809921
85peptidyl-histidine modification (GO:0018202)2.38710471
86signal transduction involved in cell cycle checkpoint (GO:0072395)2.38247198
87rRNA modification (GO:0000154)2.37785865
88aldehyde catabolic process (GO:0046185)2.37619387
89vitamin biosynthetic process (GO:0009110)2.37280503
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36751277
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.36640666
92regulation of mitotic spindle checkpoint (GO:1903504)2.36640666
93ketone body metabolic process (GO:1902224)2.36517203
94regulation of T cell receptor signaling pathway (GO:0050856)2.36158878
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.35367981
96positive regulation of T-helper 1 type immune response (GO:0002827)2.34404734
97nucleotide transmembrane transport (GO:1901679)2.34255122
98UTP metabolic process (GO:0046051)2.33305723
99regulation of immunoglobulin secretion (GO:0051023)2.32940715
100positive regulation of fatty acid transport (GO:2000193)2.32082073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.87141906
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.75000518
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.17665248
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09523930
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.07339809
6VDR_22108803_ChIP-Seq_LS180_Human3.05035783
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.95655227
8ZNF274_21170338_ChIP-Seq_K562_Hela2.78942696
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.78662108
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.78148092
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76796441
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59340196
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.54343025
14VDR_23849224_ChIP-Seq_CD4+_Human2.52426277
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28546035
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26014921
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.22322280
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.12825646
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.03040437
20ELK1_19687146_ChIP-ChIP_HELA_Human2.00457059
21FOXP3_21729870_ChIP-Seq_TREG_Human1.98960517
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97589261
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.93276552
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91790048
25IGF1R_20145208_ChIP-Seq_DFB_Human1.84258561
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.83049260
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76754234
28MYC_18940864_ChIP-ChIP_HL60_Human1.75239940
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71434482
30EWS_26573619_Chip-Seq_HEK293_Human1.70818772
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67712483
32TP53_22573176_ChIP-Seq_HFKS_Human1.65230408
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.57915397
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.57915397
35AR_20517297_ChIP-Seq_VCAP_Human1.54598218
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53645308
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51332408
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49833899
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.49804544
40GATA3_26560356_Chip-Seq_TH2_Human1.48382316
41FUS_26573619_Chip-Seq_HEK293_Human1.47037336
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45732706
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43981893
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38723785
45SOX2_19829295_ChIP-Seq_ESCs_Human1.36857150
46NANOG_19829295_ChIP-Seq_ESCs_Human1.36857150
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30705172
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30326275
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.30088010
50P300_19829295_ChIP-Seq_ESCs_Human1.28988365
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28089964
52FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27514790
53IRF1_19129219_ChIP-ChIP_H3396_Human1.27179553
54NCOR_22424771_ChIP-Seq_293T_Human1.23856292
55NANOG_20526341_ChIP-Seq_ESCs_Human1.23775454
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.20874779
57HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20126927
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19894906
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19667361
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18621215
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17343745
62BCAT_22108803_ChIP-Seq_LS180_Human1.16318063
63MYB_26560356_Chip-Seq_TH2_Human1.15689877
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14929246
65ER_23166858_ChIP-Seq_MCF-7_Human1.14310919
66MYC_19829295_ChIP-Seq_ESCs_Human1.13349292
67TAF15_26573619_Chip-Seq_HEK293_Human1.12608744
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12365985
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11785102
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.11394014
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10961871
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10125840
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09087865
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07918114
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06854649
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06491988
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.04573218
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03706382
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03006522
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.02944339
81TAF2_19829295_ChIP-Seq_ESCs_Human1.02262514
82HOXB7_26014856_ChIP-Seq_BT474_Human1.02245075
83CBP_20019798_ChIP-Seq_JUKART_Human1.01846956
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01846956
85FOXH1_21741376_ChIP-Seq_EPCs_Human1.00309284
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00284756
87TCF4_22108803_ChIP-Seq_LS180_Human0.99548806
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98559623
89RBPJ_21746931_ChIP-Seq_IB4_Human0.98213837
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97813421
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.96123988
92ERG_20517297_ChIP-Seq_VCAP_Human0.95862803
93PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95685853
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95185197
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95000884
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94298594
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.94041803
98TTF2_22483619_ChIP-Seq_HELA_Human0.92732550
99CDX2_22108803_ChIP-Seq_LS180_Human0.92415192
100MYC_18555785_ChIP-Seq_MESCs_Mouse0.91454842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.74935280
2MP0001835_abnormal_antigen_presentation3.05287464
3MP0005360_urolithiasis2.90659672
4MP0004147_increased_porphyrin_level2.66367363
5MP0002102_abnormal_ear_morphology2.47267740
6MP0006072_abnormal_retinal_apoptosis2.44271645
7MP0003195_calcinosis2.34634313
8MP0008877_abnormal_DNA_methylation2.28858921
9MP0005645_abnormal_hypothalamus_physiol2.24495295
10MP0002166_altered_tumor_susceptibility2.05347885
11MP0008872_abnormal_physiological_respon2.03151821
12MP0009785_altered_susceptibility_to2.02663034
13MP0002138_abnormal_hepatobiliary_system2.00385316
14MP0009379_abnormal_foot_pigmentation1.93842389
15MP0005085_abnormal_gallbladder_physiolo1.92404126
16MP0008875_abnormal_xenobiotic_pharmacok1.90056496
17MP0002148_abnormal_hypersensitivity_rea1.86574881
18MP0000685_abnormal_immune_system1.80687234
19MP0002876_abnormal_thyroid_physiology1.79405488
20MP0003806_abnormal_nucleotide_metabolis1.78458003
21MP0001873_stomach_inflammation1.77750955
22MP0001800_abnormal_humoral_immune1.75569660
23MP0002006_tumorigenesis1.75182436
24MP0002837_dystrophic_cardiac_calcinosis1.74837504
25MP0001790_abnormal_immune_system1.73797088
26MP0005387_immune_system_phenotype1.73797088
27MP0010155_abnormal_intestine_physiology1.70537805
28MP0002139_abnormal_hepatobiliary_system1.62774887
29MP0003011_delayed_dark_adaptation1.60055840
30MP0005084_abnormal_gallbladder_morpholo1.59680417
31MP0003724_increased_susceptibility_to1.57040272
32MP0005000_abnormal_immune_tolerance1.56607729
33MP0003866_abnormal_defecation1.55537049
34MP0005075_abnormal_melanosome_morpholog1.55042565
35MP0005551_abnormal_eye_electrophysiolog1.54938974
36MP0001986_abnormal_taste_sensitivity1.49543477
37MP0004019_abnormal_vitamin_homeostasis1.48855961
38MP0002277_abnormal_respiratory_mucosa1.45665865
39MP0001764_abnormal_homeostasis1.44431421
40MP0002723_abnormal_immune_serum1.42782596
41MP0003787_abnormal_imprinting1.42314551
42MP0003786_premature_aging1.40220423
43MP0009333_abnormal_splenocyte_physiolog1.39071020
44MP0005332_abnormal_amino_acid1.38864076
45MP0001666_abnormal_nutrient_absorption1.36952482
46MP0005253_abnormal_eye_physiology1.36648770
47MP0006292_abnormal_olfactory_placode1.34858376
48MP0002163_abnormal_gland_morphology1.33510769
49MP0003763_abnormal_thymus_physiology1.33483070
50MP0004885_abnormal_endolymph1.33289338
51MP0003718_maternal_effect1.30904319
52MP0000372_irregular_coat_pigmentation1.30500132
53MP0009764_decreased_sensitivity_to1.28594415
54MP0002420_abnormal_adaptive_immunity1.27365584
55MP0001819_abnormal_immune_cell1.26842440
56MP0001968_abnormal_touch/_nociception1.24722068
57MP0005365_abnormal_bile_salt1.23089121
58MP0002452_abnormal_antigen_presenting1.22991279
59MP0003252_abnormal_bile_duct1.20212981
60MP0001501_abnormal_sleep_pattern1.17715317
61MP0001845_abnormal_inflammatory_respons1.15798982
62MP0003878_abnormal_ear_physiology1.14575265
63MP0005377_hearing/vestibular/ear_phenot1.14575265
64MP0006036_abnormal_mitochondrial_physio1.13936594
65MP0005636_abnormal_mineral_homeostasis1.12362748
66MP0005025_abnormal_response_to1.11978860
67MP0005646_abnormal_pituitary_gland1.10965984
68MP0002736_abnormal_nociception_after1.08623999
69MP0005379_endocrine/exocrine_gland_phen1.08473152
70MP0002693_abnormal_pancreas_physiology1.04534269
71MP0008058_abnormal_DNA_repair1.04404872
72MP0004142_abnormal_muscle_tone1.02683880
73MP0003693_abnormal_embryo_hatching0.99870978
74MP0004145_abnormal_muscle_electrophysio0.98982308
75MP0001765_abnormal_ion_homeostasis0.98903427
76MP0005410_abnormal_fertilization0.98165065
77MP0001919_abnormal_reproductive_system0.97705865
78MP0003646_muscle_fatigue0.97640184
79MP0001485_abnormal_pinna_reflex0.97155689
80MP0006082_CNS_inflammation0.97047946
81MP0005389_reproductive_system_phenotype0.96189561
82MP0002638_abnormal_pupillary_reflex0.93634360
83MP0009643_abnormal_urine_homeostasis0.91324912
84MP0008469_abnormal_protein_level0.90354822
85MP0010329_abnormal_lipoprotein_level0.89077864
86MP0001188_hyperpigmentation0.88620275
87MP0000689_abnormal_spleen_morphology0.87011141
88MP0001905_abnormal_dopamine_level0.86454600
89MP0000716_abnormal_immune_system0.86231100
90MP0003186_abnormal_redox_activity0.86158370
91MP0010386_abnormal_urinary_bladder0.85797150
92MP0002938_white_spotting0.85664626
93MP0002254_reproductive_system_inflammat0.84694167
94MP0002272_abnormal_nervous_system0.82710964
95MP0000013_abnormal_adipose_tissue0.79490912
96MP0002398_abnormal_bone_marrow0.79384832
97MP0008775_abnormal_heart_ventricle0.76672969
98MP0003283_abnormal_digestive_organ0.75269832
99MP0003638_abnormal_response/metabolism_0.75225683
100MP0001663_abnormal_digestive_system0.70661573

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.63127122
2IgG deficiency (HP:0004315)3.59068621
3Mitochondrial inheritance (HP:0001427)3.51945303
4Acute encephalopathy (HP:0006846)3.25253152
5Abnormal mitochondria in muscle tissue (HP:0008316)3.24909930
6Increased CSF lactate (HP:0002490)3.23372456
7Abolished electroretinogram (ERG) (HP:0000550)3.14867552
8Increased hepatocellular lipid droplets (HP:0006565)3.14371597
9Progressive macrocephaly (HP:0004481)3.13485174
10Lipid accumulation in hepatocytes (HP:0006561)3.11497975
11Stomatitis (HP:0010280)3.09338255
12Pancreatic cysts (HP:0001737)3.03208336
13Hepatocellular necrosis (HP:0001404)2.99283590
14Congenital stationary night blindness (HP:0007642)2.99248665
15Hepatic necrosis (HP:0002605)2.95726866
16Type II lissencephaly (HP:0007260)2.92834521
173-Methylglutaconic aciduria (HP:0003535)2.91051080
18Elevated erythrocyte sedimentation rate (HP:0003565)2.77453343
19Decreased electroretinogram (ERG) amplitude (HP:0000654)2.74038421
20Abnormality of the renal cortex (HP:0011035)2.72042007
21Abnormality of midbrain morphology (HP:0002418)2.67935956
22Molar tooth sign on MRI (HP:0002419)2.67935956
23Methylmalonic acidemia (HP:0002912)2.65466223
24Abnormality of the pons (HP:0007361)2.65249501
25Congenital, generalized hypertrichosis (HP:0004540)2.64933459
26Pancreatic fibrosis (HP:0100732)2.64315844
27Glycosuria (HP:0003076)2.64314725
28Abnormality of urine glucose concentration (HP:0011016)2.64314725
29Hypoproteinemia (HP:0003075)2.63536458
30Cerebral edema (HP:0002181)2.59929042
31Severe combined immunodeficiency (HP:0004430)2.55648260
32Renal Fanconi syndrome (HP:0001994)2.54534732
33Chronic diarrhea (HP:0002028)2.53744454
34Hypoplasia of the pons (HP:0012110)2.53554738
35Methylmalonic aciduria (HP:0012120)2.50824492
36Renal cortical cysts (HP:0000803)2.50594429
37True hermaphroditism (HP:0010459)2.49224583
38Abnormality of vitamin B metabolism (HP:0004340)2.44667229
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.44347160
40Thyroiditis (HP:0100646)2.40759633
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40517384
42Increased serum lactate (HP:0002151)2.39526007
43Lethargy (HP:0001254)2.38818375
44Lactic acidosis (HP:0003128)2.31812268
45Optic disc pallor (HP:0000543)2.31197022
46Nephronophthisis (HP:0000090)2.29840630
47Abnormality of the vitamin B12 metabolism (HP:0004341)2.29651448
48Abnormal rod and cone electroretinograms (HP:0008323)2.29408766
49Increased intramyocellular lipid droplets (HP:0012240)2.27737523
50Aplastic anemia (HP:0001915)2.26943782
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26378736
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26378736
53Exertional dyspnea (HP:0002875)2.20684502
54Increased IgM level (HP:0003496)2.19768282
55Dicarboxylic aciduria (HP:0003215)2.15991420
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15991420
57Abnormality of the prostate (HP:0008775)2.15717136
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14591849
59Hyperglycinuria (HP:0003108)2.14362453
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13796879
61Hypothermia (HP:0002045)2.12693329
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12594129
63Abnormality of T cell number (HP:0011839)2.09514161
64Type I transferrin isoform profile (HP:0003642)2.08567135
65Attenuation of retinal blood vessels (HP:0007843)2.07262352
66Abnormality of T cells (HP:0002843)2.05342611
67Bile duct proliferation (HP:0001408)2.04895469
68Abnormal biliary tract physiology (HP:0012439)2.04895469
69Abnormality of the renal medulla (HP:0100957)2.04216196
70T lymphocytopenia (HP:0005403)2.02564711
71Increased muscle lipid content (HP:0009058)2.00835285
72Hypoalbuminemia (HP:0003073)2.00346414
73Abnormal albumin level (HP:0012116)2.00346414
74Abnormal drinking behavior (HP:0030082)1.99670934
75Polydipsia (HP:0001959)1.99670934
76Abnormality of glycine metabolism (HP:0010895)1.99496396
77Abnormality of serine family amino acid metabolism (HP:0010894)1.99496396
78Tongue fasciculations (HP:0001308)1.98747384
79Hypomagnesemia (HP:0002917)1.95521060
80Respiratory failure (HP:0002878)1.94874986
81Panhypogammaglobulinemia (HP:0003139)1.93948799
82Medial flaring of the eyebrow (HP:0010747)1.92692952
83Aplasia/hypoplasia of the uterus (HP:0008684)1.92363913
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.89733790
85Abnormality of magnesium homeostasis (HP:0004921)1.89450480
86Cerebellar dysplasia (HP:0007033)1.89071638
87Abnormality of eosinophils (HP:0001879)1.88691224
88Combined immunodeficiency (HP:0005387)1.85536902
89Abnormality of alanine metabolism (HP:0010916)1.84415951
90Hyperalaninemia (HP:0003348)1.84415951
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84415951
92Absent/shortened dynein arms (HP:0200106)1.83340764
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.83340764
94Generalized aminoaciduria (HP:0002909)1.82007851
95Hyperphosphaturia (HP:0003109)1.80705630
96Asplenia (HP:0001746)1.80109464
97Reticulocytopenia (HP:0001896)1.78738864
98Abnormality of B cell number (HP:0010975)1.78490683
99Colon cancer (HP:0003003)1.77682166
100Abnormality of T cell physiology (HP:0011840)1.77457446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.61235679
2ZAK3.23787211
3MAP4K22.82077491
4TAOK32.79677785
5MST42.78172968
6NUAK12.77370133
7TLK12.68705950
8VRK22.66560258
9ADRBK22.62503726
10FRK2.47440174
11GRK12.16085926
12STK161.90681385
13PASK1.87134871
14TIE11.81230144
15VRK11.78520778
16MAP4K11.74364396
17CDK191.71752315
18EIF2AK31.69317566
19MAP3K121.65286876
20WNK31.61607916
21ACVR1B1.61347373
22BCKDK1.57748904
23TEC1.48485616
24BMPR1B1.48325590
25OXSR11.45635959
26TSSK61.45600519
27KDR1.35624556
28WNK41.31938731
29TRIM281.21648744
30INSRR1.21342277
31ITK1.19502393
32IKBKB1.15693394
33KIT1.13957193
34STK391.12312120
35PINK11.10038195
36TAF11.04873029
37BUB11.02900606
38FES1.02640091
39NME10.98585594
40TESK20.98481967
41NLK0.98366278
42PLK30.97788698
43MYLK0.91833324
44IKBKE0.89517271
45CSNK1G30.89184284
46MAP2K60.86919600
47NEK10.85777606
48DAPK10.83587130
49CSNK1G10.83399180
50GRK60.80600604
51PRKCQ0.80548885
52MUSK0.79536011
53SYK0.78565953
54DAPK20.74033629
55CSNK1G20.73904972
56DYRK20.73741718
57ERBB30.73273747
58PHKG10.72396218
59PHKG20.72396218
60PRKCE0.71660452
61TGFBR10.70180838
62RPS6KA50.69037377
63BMPR20.68050659
64SRPK10.67866991
65TNIK0.61222603
66LCK0.61036509
67EIF2AK20.60992871
68MAP2K20.60284936
69MKNK10.59079698
70MAP3K140.57707060
71MKNK20.56577671
72LYN0.56427764
73PLK40.55924611
74FLT30.52848412
75MATK0.51273324
76PIM10.50408327
77ADRBK10.49749319
78JAK30.47610894
79MAPK130.46485758
80LIMK10.45487730
81CSNK1A1L0.45472762
82IRAK10.43383101
83CSF1R0.42623453
84IGF1R0.42014656
85BTK0.41805410
86MARK30.40585138
87PRKCA0.40081731
88RPS6KA40.39735481
89BRSK20.37903585
90PLK20.37650447
91CAMKK20.36997727
92CSNK1A10.36867353
93GRK50.36774074
94GRK70.36770073
95BCR0.36290125
96PAK30.36064664
97CSNK2A20.35499729
98PTK2B0.35151894
99EIF2AK10.34787076
100PRKCG0.33981291

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.33252308
2Proteasome_Homo sapiens_hsa030503.14308788
3Allograft rejection_Homo sapiens_hsa053302.97170849
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.84528176
5Autoimmune thyroid disease_Homo sapiens_hsa053202.82631778
6Oxidative phosphorylation_Homo sapiens_hsa001902.79732953
7Graft-versus-host disease_Homo sapiens_hsa053322.66182381
8Type I diabetes mellitus_Homo sapiens_hsa049402.62071936
9Primary immunodeficiency_Homo sapiens_hsa053402.48581975
10Protein export_Homo sapiens_hsa030602.35984869
11Parkinsons disease_Homo sapiens_hsa050122.25836410
12Ribosome_Homo sapiens_hsa030102.21165464
13RNA polymerase_Homo sapiens_hsa030201.90695221
14Linoleic acid metabolism_Homo sapiens_hsa005911.82980805
15Antigen processing and presentation_Homo sapiens_hsa046121.82219495
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80134379
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74242715
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62484697
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.59129097
20Fat digestion and absorption_Homo sapiens_hsa049751.58619418
21Sulfur metabolism_Homo sapiens_hsa009201.57218302
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54861686
23Caffeine metabolism_Homo sapiens_hsa002321.46215679
24Propanoate metabolism_Homo sapiens_hsa006401.43759897
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37632193
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35902102
27Huntingtons disease_Homo sapiens_hsa050161.33264718
28Alzheimers disease_Homo sapiens_hsa050101.33165669
29Phototransduction_Homo sapiens_hsa047441.32911888
30Vitamin digestion and absorption_Homo sapiens_hsa049771.29826412
31Tryptophan metabolism_Homo sapiens_hsa003801.23581511
32Nitrogen metabolism_Homo sapiens_hsa009101.22729280
33Butanoate metabolism_Homo sapiens_hsa006501.19777451
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19215145
35RNA degradation_Homo sapiens_hsa030181.18701461
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16579377
37Rheumatoid arthritis_Homo sapiens_hsa053231.16244283
38Peroxisome_Homo sapiens_hsa041461.13329572
39Homologous recombination_Homo sapiens_hsa034401.13293669
40Basal transcription factors_Homo sapiens_hsa030221.13008247
41Chemical carcinogenesis_Homo sapiens_hsa052041.11498645
42Hematopoietic cell lineage_Homo sapiens_hsa046401.04460425
43Arachidonic acid metabolism_Homo sapiens_hsa005901.03007013
44Ether lipid metabolism_Homo sapiens_hsa005651.01358492
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95563233
46Retinol metabolism_Homo sapiens_hsa008300.93020686
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92717086
48One carbon pool by folate_Homo sapiens_hsa006700.90856747
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.88498392
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86269632
51Pyrimidine metabolism_Homo sapiens_hsa002400.85154459
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84747843
53Cardiac muscle contraction_Homo sapiens_hsa042600.84083579
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83878699
55Purine metabolism_Homo sapiens_hsa002300.79312498
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75809555
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.75130006
58Viral myocarditis_Homo sapiens_hsa054160.72279845
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71266896
60Regulation of autophagy_Homo sapiens_hsa041400.71260980
61Sulfur relay system_Homo sapiens_hsa041220.70101866
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69825455
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68213359
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67814806
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67041333
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66812611
67Staphylococcus aureus infection_Homo sapiens_hsa051500.66092517
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65369905
69Glutathione metabolism_Homo sapiens_hsa004800.64111461
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.63089145
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.62432071
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61287871
73Fanconi anemia pathway_Homo sapiens_hsa034600.60612021
74Fatty acid degradation_Homo sapiens_hsa000710.60562946
75Metabolic pathways_Homo sapiens_hsa011000.60094417
76Fatty acid elongation_Homo sapiens_hsa000620.58822725
77Mineral absorption_Homo sapiens_hsa049780.57343372
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.57223459
79Selenocompound metabolism_Homo sapiens_hsa004500.57066823
80Systemic lupus erythematosus_Homo sapiens_hsa053220.56244955
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55084481
82Non-homologous end-joining_Homo sapiens_hsa034500.53432586
83RNA transport_Homo sapiens_hsa030130.53297705
84Folate biosynthesis_Homo sapiens_hsa007900.53267602
85Nucleotide excision repair_Homo sapiens_hsa034200.52843536
86Vitamin B6 metabolism_Homo sapiens_hsa007500.52031463
87Mismatch repair_Homo sapiens_hsa034300.51176217
88Spliceosome_Homo sapiens_hsa030400.50652375
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.50471805
90Collecting duct acid secretion_Homo sapiens_hsa049660.46614355
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44886978
92Pyruvate metabolism_Homo sapiens_hsa006200.42372617
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40357303
94T cell receptor signaling pathway_Homo sapiens_hsa046600.37753985
95Leishmaniasis_Homo sapiens_hsa051400.36733822
96beta-Alanine metabolism_Homo sapiens_hsa004100.35182540
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33785189
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33552461
99Renin-angiotensin system_Homo sapiens_hsa046140.33408058
100Olfactory transduction_Homo sapiens_hsa047400.33382705

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