ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.83165128
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.57184688
3	ATP synthesis coupled proton transport (GO:0015986)	4.57184688
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.36360610
5	ribosomal small subunit assembly (GO:0000028)	4.32811412
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.17818937
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.11500129
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.84945536
9	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.84945536
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.70791471
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.65448968
12	protein complex biogenesis (GO:0070271)	3.57349291
13	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.54631384
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.51917857
15	platelet dense granule organization (GO:0060155)	3.50281045
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42819751
17	NADH dehydrogenase complex assembly (GO:0010257)	3.42819751
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42819751
19	cytidine deamination (GO:0009972)	3.41562658
20	cytidine metabolic process (GO:0046087)	3.41562658
21	cytidine catabolic process (GO:0006216)	3.41562658
22	proteasome assembly (GO:0043248)	3.39286030
23	protein neddylation (GO:0045116)	3.28707606
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.26587423
25	respiratory chain complex IV assembly (GO:0008535)	3.21462460
26	regulation of cellular amino acid metabolic process (GO:0006521)	3.21132719
27	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.20416776
28	termination of RNA polymerase III transcription (GO:0006386)	3.20416776
29	electron transport chain (GO:0022900)	3.19089124
30	respiratory electron transport chain (GO:0022904)	3.18399336
31	GTP biosynthetic process (GO:0006183)	3.16864611
32	ribosomal large subunit biogenesis (GO:0042273)	3.16381769
33	response to pheromone (GO:0019236)	3.11634740
34	protein deneddylation (GO:0000338)	3.08677892
35	pseudouridine synthesis (GO:0001522)	3.08349756
36	cullin deneddylation (GO:0010388)	3.06056299
37	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.02677617
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.01015300
39	mannosylation (GO:0097502)	3.00486509
40	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.99687410
41	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.92930496
42	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.92930496
43	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.92930496
44	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90721738
45	GPI anchor metabolic process (GO:0006505)	2.90111492
46	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.88191289
47	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.88191289
48	cytochrome complex assembly (GO:0017004)	2.86988287
49	maturation of 5.8S rRNA (GO:0000460)	2.85141702
50	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.85128528
51	behavioral response to nicotine (GO:0035095)	2.84143582
52	chaperone-mediated protein transport (GO:0072321)	2.82776294
53	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.80792981
54	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.80792981
55	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.80291370
56	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.79817693
57	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.78540514
58	GPI anchor biosynthetic process (GO:0006506)	2.76306293
59	tRNA processing (GO:0008033)	2.74333417
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.74268652
61	fucose catabolic process (GO:0019317)	2.74198464
62	L-fucose metabolic process (GO:0042354)	2.74198464
63	L-fucose catabolic process (GO:0042355)	2.74198464
64	negative regulation of telomere maintenance (GO:0032205)	2.73170056
65	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.70330148
66	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.69091638
67	rRNA modification (GO:0000154)	2.68850685
68	sequestering of actin monomers (GO:0042989)	2.68777624
69	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.67127537
70	positive regulation of defense response to virus by host (GO:0002230)	2.66460120
71	translation (GO:0006412)	2.65791649
72	cotranslational protein targeting to membrane (GO:0006613)	2.64879770
73	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.63607169
74	negative regulation of ligase activity (GO:0051352)	2.63607169
75	peptidyl-histidine modification (GO:0018202)	2.63055970
76	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.62350901
77	protein targeting to ER (GO:0045047)	2.62081956
78	ATP biosynthetic process (GO:0006754)	2.60817296
79	positive regulation of prostaglandin secretion (GO:0032308)	2.60062262
80	metallo-sulfur cluster assembly (GO:0031163)	2.59561048
81	iron-sulfur cluster assembly (GO:0016226)	2.59561048
82	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.57348252
83	translational elongation (GO:0006414)	2.57088466
84	hydrogen ion transmembrane transport (GO:1902600)	2.56566409
85	UTP biosynthetic process (GO:0006228)	2.56514781
86	proton transport (GO:0015992)	2.56442624
87	base-excision repair, AP site formation (GO:0006285)	2.55827088
88	maturation of SSU-rRNA (GO:0030490)	2.54586177
89	indolalkylamine metabolic process (GO:0006586)	2.52761204
90	protein localization to endoplasmic reticulum (GO:0070972)	2.52708251
91	hydrogen transport (GO:0006818)	2.51336136
92	ubiquinone biosynthetic process (GO:0006744)	2.50559942
93	xenobiotic catabolic process (GO:0042178)	2.50002114
94	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.49809658
95	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.49809658
96	isotype switching (GO:0045190)	2.49809658
97	viral transcription (GO:0019083)	2.49678229
98	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.48511930
99	rRNA catabolic process (GO:0016075)	2.48093137
100	UTP metabolic process (GO:0046051)	2.47604999

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.24043089
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.91917227
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.76098962
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.44353348
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.07832082
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.97889459
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.95878674
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.85577417
9	VDR_22108803_ChIP-Seq_LS180_Human	2.84152202
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.77731526
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.73034834
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69017016
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.61519157
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44715888
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.42400427
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32169092
17	FOXP3_21729870_ChIP-Seq_TREG_Human	2.17542783
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12054902
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.11828192
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.10561461
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01619018
22	MYC_18940864_ChIP-ChIP_HL60_Human	2.00739787
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.97672303
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96070013
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.88602907
26	EWS_26573619_Chip-Seq_HEK293_Human	1.84491227
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.81567595
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.72923313
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.68772561
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.60221671
31	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.57092715
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55800416
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.54464186
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.54135659
35	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.49063550
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46626122
37	FUS_26573619_Chip-Seq_HEK293_Human	1.45024450
38	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.44709506
39	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.42962791
40	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.41541098
41	P300_19829295_ChIP-Seq_ESCs_Human	1.40449089
42	AR_20517297_ChIP-Seq_VCAP_Human	1.38402707
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37733399
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.36350428
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36125513
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36125513
47	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.34078265
48	TAF15_26573619_Chip-Seq_HEK293_Human	1.34044568
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32738442
50	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.30424915
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27984263
52	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.26401150
53	GATA3_26560356_Chip-Seq_TH2_Human	1.25299910
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.24089066
55	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.23973006
56	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23453302
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.23390350
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22736943
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21291940
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21291940
61	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.20112911
62	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.19913528
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.18873742
64	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16505053
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16405685
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.16405685
67	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14731240
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14531277
69	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.14323865
70	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.14231059
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.13205021
72	GABP_19822575_ChIP-Seq_HepG2_Human	1.11936961
73	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11341693
74	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.11032484
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09524512
76	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.08498614
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08131356
78	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.07986633
79	NCOR_22424771_ChIP-Seq_293T_Human	1.07006257
80	MYB_26560356_Chip-Seq_TH2_Human	1.06605684
81	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04798313
82	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03743328
83	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.03091362
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01737615
85	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.01424645
86	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.00818497
87	ERG_20517297_ChIP-Seq_VCAP_Human	0.97980065
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97240153
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96315450
90	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95844146
91	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.95393733
92	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.95004874
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94993830
94	GBX2_23144817_ChIP-Seq_PC3_Human	0.94716685
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93644340
96	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.91813235
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90573021
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.89769593
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.89223583
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.88705500

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.78865738
2	MP0002102_abnormal_ear_morphology	3.09636281
3	MP0006072_abnormal_retinal_apoptosis	2.94411865
4	MP0008877_abnormal_DNA_methylation	2.65730886
5	MP0001835_abnormal_antigen_presentation	2.55359302
6	MP0005084_abnormal_gallbladder_morpholo	2.46476148
7	MP0003011_delayed_dark_adaptation	2.28926034
8	MP0006292_abnormal_olfactory_placode	2.23535287
9	MP0003195_calcinosis	2.16793044
10	MP0002163_abnormal_gland_morphology	2.12589430
11	MP0008872_abnormal_physiological_respon	1.98091174
12	MP0002138_abnormal_hepatobiliary_system	1.94001642
13	MP0008058_abnormal_DNA_repair	1.92027627
14	MP0004147_increased_porphyrin_level	1.91163328
15	MP0005645_abnormal_hypothalamus_physiol	1.90784972
16	MP0002166_altered_tumor_susceptibility	1.90017298
17	MP0008875_abnormal_xenobiotic_pharmacok	1.88395352
18	MP0009785_altered_susceptibility_to	1.87426099
19	MP0000372_irregular_coat_pigmentation	1.85325075
20	MP0001529_abnormal_vocalization	1.83813815
21	MP0005075_abnormal_melanosome_morpholog	1.81205911
22	MP0002876_abnormal_thyroid_physiology	1.79949537
23	MP0002837_dystrophic_cardiac_calcinosis	1.76876456
24	MP0005253_abnormal_eye_physiology	1.74227388
25	MP0002006_tumorigenesis	1.72224352
26	MP0003786_premature_aging	1.72216328
27	MP0005551_abnormal_eye_electrophysiolog	1.62276383
28	MP0003806_abnormal_nucleotide_metabolis	1.58646118
29	MP0005379_endocrine/exocrine_gland_phen	1.56300796
30	MP0004885_abnormal_endolymph	1.55609135
31	MP0008995_early_reproductive_senescence	1.50892151
32	MP0002148_abnormal_hypersensitivity_rea	1.49795487
33	MP0002938_white_spotting	1.49745412
34	MP0001986_abnormal_taste_sensitivity	1.48967144
35	MP0009379_abnormal_foot_pigmentation	1.45669713
36	MP0001800_abnormal_humoral_immune	1.38706107
37	MP0005000_abnormal_immune_tolerance	1.35348513
38	MP0005646_abnormal_pituitary_gland	1.34762225
39	MP0001968_abnormal_touch/_nociception	1.33728132
40	MP0002736_abnormal_nociception_after	1.33636566
41	MP0002638_abnormal_pupillary_reflex	1.29516047
42	MP0001905_abnormal_dopamine_level	1.29353014
43	MP0005389_reproductive_system_phenotype	1.28781648
44	MP0001919_abnormal_reproductive_system	1.25923357
45	MP0001873_stomach_inflammation	1.24791088
46	MP0004145_abnormal_muscle_electrophysio	1.24594840
47	MP0000685_abnormal_immune_system	1.22435321
48	MP0002277_abnormal_respiratory_mucosa	1.22274160
49	MP0004142_abnormal_muscle_tone	1.21162821
50	MP0003646_muscle_fatigue	1.20489291
51	MP0003763_abnormal_thymus_physiology	1.20404148
52	MP0009333_abnormal_splenocyte_physiolog	1.19772752
53	MP0001764_abnormal_homeostasis	1.17802870
54	MP0003283_abnormal_digestive_organ	1.17708882
55	MP0002723_abnormal_immune_serum	1.12465334
56	MP0003252_abnormal_bile_duct	1.10614084
57	MP0005410_abnormal_fertilization	1.08731754
58	MP0002693_abnormal_pancreas_physiology	1.03883348
59	MP0009764_decreased_sensitivity_to	1.03392789
60	MP0002420_abnormal_adaptive_immunity	1.03298119
61	MP0001819_abnormal_immune_cell	1.02954008
62	MP0005085_abnormal_gallbladder_physiolo	1.01061417
63	MP0006036_abnormal_mitochondrial_physio	1.00326274
64	MP0002452_abnormal_antigen_presenting	0.99943597
65	MP0005360_urolithiasis	0.98922279
66	MP0002234_abnormal_pharynx_morphology	0.98181951
67	MP0005332_abnormal_amino_acid	0.97685615
68	MP0003787_abnormal_imprinting	0.97535911
69	MP0003866_abnormal_defecation	0.97213142
70	MP0003186_abnormal_redox_activity	0.97008557
71	MP0002160_abnormal_reproductive_system	0.95953006
72	MP0003718_maternal_effect	0.95390196
73	MP0009697_abnormal_copulation	0.94365280
74	MP0000613_abnormal_salivary_gland	0.93343896
75	MP0006276_abnormal_autonomic_nervous	0.92492838
76	MP0008789_abnormal_olfactory_epithelium	0.92391765
77	MP0002928_abnormal_bile_duct	0.91850738
78	MP0001790_abnormal_immune_system	0.89775886
79	MP0005387_immune_system_phenotype	0.89775886
80	MP0000465_gastrointestinal_hemorrhage	0.88056287
81	MP0000631_abnormal_neuroendocrine_gland	0.84825023
82	MP0003724_increased_susceptibility_to	0.81896268
83	MP0002751_abnormal_autonomic_nervous	0.81316078
84	MP0001845_abnormal_inflammatory_respons	0.81114256
85	MP0005636_abnormal_mineral_homeostasis	0.80756139
86	MP0001501_abnormal_sleep_pattern	0.78201667
87	MP0002272_abnormal_nervous_system	0.78067291
88	MP0000689_abnormal_spleen_morphology	0.77244371
89	MP0005025_abnormal_response_to	0.77144744
90	MP0003693_abnormal_embryo_hatching	0.76819729
91	MP0003878_abnormal_ear_physiology	0.76504506
92	MP0005377_hearing/vestibular/ear_phenot	0.76504506
93	MP0001119_abnormal_female_reproductive	0.76097787
94	MP0003880_abnormal_central_pattern	0.75869899
95	MP0005365_abnormal_bile_salt	0.72810474
96	MP0010094_abnormal_chromosome_stability	0.72621105
97	MP0003567_abnormal_fetal_cardiomyocyte	0.72105518
98	MP0002095_abnormal_skin_pigmentation	0.71980584
99	MP0010155_abnormal_intestine_physiology	0.71658852
100	MP0000716_abnormal_immune_system	0.71296914

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.94990084
2	Mitochondrial inheritance (HP:0001427)	3.86180650
3	Increased CSF lactate (HP:0002490)	3.63536218
4	Increased hepatocellular lipid droplets (HP:0006565)	3.63231960
5	Lipid accumulation in hepatocytes (HP:0006561)	3.53832504
6	Acute encephalopathy (HP:0006846)	3.49548170
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.47140235
8	IgG deficiency (HP:0004315)	3.43880879
9	Progressive macrocephaly (HP:0004481)	3.37819241
10	Hepatocellular necrosis (HP:0001404)	3.34256126
11	Pancreatic cysts (HP:0001737)	3.32252096
12	Hepatic necrosis (HP:0002605)	3.18727234
13	Congenital stationary night blindness (HP:0007642)	3.13592914
14	Methylmalonic acidemia (HP:0002912)	3.08383031
15	Abolished electroretinogram (ERG) (HP:0000550)	2.92523466
16	Renal cortical cysts (HP:0000803)	2.90622566
17	True hermaphroditism (HP:0010459)	2.88847732
18	Congenital, generalized hypertrichosis (HP:0004540)	2.86204007
19	Renal Fanconi syndrome (HP:0001994)	2.83657282
20	Hypoproteinemia (HP:0003075)	2.82153258
21	Pancreatic fibrosis (HP:0100732)	2.81419949
22	3-Methylglutaconic aciduria (HP:0003535)	2.79588600
23	Severe combined immunodeficiency (HP:0004430)	2.76227381
24	Abnormality of the renal cortex (HP:0011035)	2.71496309
25	Cerebral edema (HP:0002181)	2.69598092
26	Increased serum lactate (HP:0002151)	2.67344629
27	Increased intramyocellular lipid droplets (HP:0012240)	2.56398158
28	Methylmalonic aciduria (HP:0012120)	2.50883613
29	Aplastic anemia (HP:0001915)	2.48558852
30	Optic disc pallor (HP:0000543)	2.47559156
31	Abnormality of midbrain morphology (HP:0002418)	2.46816113
32	Molar tooth sign on MRI (HP:0002419)	2.46816113
33	Lactic acidosis (HP:0003128)	2.46568650
34	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45193453
35	Thyroiditis (HP:0100646)	2.44548951
36	Stomatitis (HP:0010280)	2.43088599
37	Attenuation of retinal blood vessels (HP:0007843)	2.41443090
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.39979462
39	Abnormality of the prostate (HP:0008775)	2.39239286
40	Exertional dyspnea (HP:0002875)	2.37979432
41	Nephronophthisis (HP:0000090)	2.37632154
42	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.37337373
43	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34623427
44	Hypothermia (HP:0002045)	2.34368171
45	Hyperglycinemia (HP:0002154)	2.31897673
46	Elevated erythrocyte sedimentation rate (HP:0003565)	2.31861525
47	Abnormality of B cell number (HP:0010975)	2.30324301
48	Type I transferrin isoform profile (HP:0003642)	2.27441472
49	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.19935826
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.19935826
51	Aplasia/hypoplasia of the uterus (HP:0008684)	2.19626568
52	Type 2 muscle fiber atrophy (HP:0003554)	2.18859243
53	Abnormality of T cell number (HP:0011839)	2.18353973
54	Increased muscle lipid content (HP:0009058)	2.15705471
55	Abnormality of alanine metabolism (HP:0010916)	2.14597457
56	Hyperalaninemia (HP:0003348)	2.14597457
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.14597457
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12587762
59	Lethargy (HP:0001254)	2.11504778
60	Medial flaring of the eyebrow (HP:0010747)	2.10943542
61	Abnormal protein glycosylation (HP:0012346)	2.10715312
62	Abnormal glycosylation (HP:0012345)	2.10715312
63	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.10715312
64	Abnormal protein N-linked glycosylation (HP:0012347)	2.10715312
65	T lymphocytopenia (HP:0005403)	2.10394961
66	Pendular nystagmus (HP:0012043)	2.09493357
67	Glycosuria (HP:0003076)	2.09339307
68	Abnormality of urine glucose concentration (HP:0011016)	2.09339307
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.06793927
70	Abnormality of the pons (HP:0007361)	2.04567028
71	Decreased central vision (HP:0007663)	2.04190032
72	Respiratory failure (HP:0002878)	2.02304319
73	Combined immunodeficiency (HP:0005387)	2.02187759
74	Abnormality of the renal medulla (HP:0100957)	2.02090281
75	Constricted visual fields (HP:0001133)	1.97124763
76	Type II lissencephaly (HP:0007260)	1.94563461
77	B lymphocytopenia (HP:0010976)	1.93319981
78	Abnormality of T cells (HP:0002843)	1.91140916
79	Abnormality of serum amino acid levels (HP:0003112)	1.89898905
80	Hypoplasia of the pons (HP:0012110)	1.88415427
81	Abnormality of vitamin B metabolism (HP:0004340)	1.88251360
82	Pancytopenia (HP:0001876)	1.88211554
83	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.88136404
84	Dicarboxylic aciduria (HP:0003215)	1.88136404
85	Abnormality of glycine metabolism (HP:0010895)	1.87517730
86	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87517730
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.87330900
88	Abnormality of eosinophils (HP:0001879)	1.87152285
89	Increased corneal curvature (HP:0100692)	1.83422623
90	Keratoconus (HP:0000563)	1.83422623
91	Abnormal number of erythroid precursors (HP:0012131)	1.82749319
92	Sclerocornea (HP:0000647)	1.82741272
93	Increased IgM level (HP:0003496)	1.82662716
94	Colon cancer (HP:0003003)	1.81872217
95	Leukodystrophy (HP:0002415)	1.81212425
96	Bile duct proliferation (HP:0001408)	1.81156990
97	Abnormal biliary tract physiology (HP:0012439)	1.81156990
98	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.79827998
99	Asplenia (HP:0001746)	1.79751734
100	Hyperglycinuria (HP:0003108)	1.76648802

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.87619678
2	TLK1	3.83135203
3	MAP4K2	3.51033212
4	TXK	3.16458111
5	VRK2	2.66896505
6	NUAK1	2.55332302
7	TAOK3	2.36316830
8	VRK1	2.28559526
9	ADRBK2	2.23846925
10	BCKDK	2.15659542
11	GRK1	2.09690747
12	FRK	2.05301921
13	EIF2AK3	1.98723841
14	PASK	1.94109051
15	CDK19	1.79724348
16	MAP3K12	1.79157822
17	MST4	1.71878053
18	KDR	1.71648259
19	STK16	1.67657471
20	WNK3	1.67406776
21	PINK1	1.61756779
22	BUB1	1.43701513
23	SRPK1	1.29849989
24	TSSK6	1.28282982
25	GRK6	1.15858344
26	FES	1.15533331
27	CSNK1G3	1.14033891
28	TRIM28	1.12459442
29	CSNK1G1	1.12431419
30	TIE1	1.09115310
31	IKBKB	1.07173022
32	WNK4	1.04829697
33	ITK	1.00725727
34	TESK2	1.00692570
35	ERBB3	1.00623117
36	OXSR1	1.00041683
37	RPS6KA5	0.99241561
38	KIT	0.99162873
39	BMPR1B	0.99005254
40	TEC	0.98840301
41	CSNK1G2	0.98742491
42	INSRR	0.98462021
43	PLK3	0.97687551
44	MAP4K1	0.93056465
45	MUSK	0.91434466
46	BMPR2	0.90814207
47	SCYL2	0.90233027
48	MAP3K4	0.86251228
49	MKNK1	0.83373675
50	CSNK1A1L	0.81564969
51	DYRK2	0.79124454
52	RPS6KA4	0.78405567
53	NME1	0.77626767
54	SYK	0.77079160
55	IKBKE	0.76489600
56	DAPK1	0.75219609
57	NEK1	0.74113466
58	MAPK13	0.73010103
59	MYLK	0.72137585
60	EIF2AK2	0.71332000
61	CDC7	0.70307793
62	STK39	0.69999592
63	TAF1	0.65177428
64	BCR	0.64372364
65	FLT3	0.63994033
66	CAMKK2	0.60466956
67	CSF1R	0.60227477
68	PRKCQ	0.60022948
69	LIMK1	0.58735975
70	PLK2	0.58712104
71	MAPKAPK3	0.58281721
72	LYN	0.57541840
73	PLK4	0.56330097
74	LCK	0.55004593
75	MAP2K6	0.54757982
76	PHKG2	0.53783574
77	PHKG1	0.53783574
78	MAP2K7	0.52885725
79	PRKCE	0.51160325
80	ADRBK1	0.50936004
81	GRK7	0.48869337
82	AURKB	0.46263705
83	ATR	0.44835371
84	IGF1R	0.44513773
85	DAPK3	0.44288170
86	MAP3K14	0.43998064
87	MKNK2	0.43288351
88	PLK1	0.42469546
89	MAPKAPK5	0.41867402
90	PIM1	0.41257222
91	CSNK2A1	0.40478245
92	CSNK1A1	0.40138844
93	BTK	0.38801648
94	MAP2K2	0.38546861
95	PRKCG	0.38257848
96	AURKA	0.37543471
97	CSNK2A2	0.37283514
98	PBK	0.36730036
99	TGFBR1	0.35885089
100	WEE1	0.35445512

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.76435346
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.22659100
3	Protein export_Homo sapiens_hsa03060	2.87684573
4	Asthma_Homo sapiens_hsa05310	2.80676479
5	Ribosome_Homo sapiens_hsa03010	2.79076960
6	Parkinsons disease_Homo sapiens_hsa05012	2.55650389
7	Allograft rejection_Homo sapiens_hsa05330	2.49354467
8	RNA polymerase_Homo sapiens_hsa03020	2.47431626
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.36767538
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.33835714
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.31972217
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.30921567
13	Primary immunodeficiency_Homo sapiens_hsa05340	2.26054190
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.03675915
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.76809810
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.72788210
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70649490
18	RNA degradation_Homo sapiens_hsa03018	1.69615205
19	Alzheimers disease_Homo sapiens_hsa05010	1.58099343
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.57684844
21	Huntingtons disease_Homo sapiens_hsa05016	1.57388144
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56606469
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.51710881
24	Phototransduction_Homo sapiens_hsa04744	1.50005607
25	Basal transcription factors_Homo sapiens_hsa03022	1.41776777
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.40911559
27	Homologous recombination_Homo sapiens_hsa03440	1.37008386
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.36697078
29	One carbon pool by folate_Homo sapiens_hsa00670	1.35811929
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34570428
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34487964
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.33425982
33	Propanoate metabolism_Homo sapiens_hsa00640	1.31446947
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31139596
35	Sulfur metabolism_Homo sapiens_hsa00920	1.30988961
36	Rheumatoid arthritis_Homo sapiens_hsa05323	1.30350434
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23152236
38	Spliceosome_Homo sapiens_hsa03040	1.20137336
39	Pyrimidine metabolism_Homo sapiens_hsa00240	1.19201031
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12400544
41	RNA transport_Homo sapiens_hsa03013	1.10380607
42	Mismatch repair_Homo sapiens_hsa03430	1.09027799
43	Peroxisome_Homo sapiens_hsa04146	1.07818938
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06693547
45	Purine metabolism_Homo sapiens_hsa00230	1.05959017
46	Nucleotide excision repair_Homo sapiens_hsa03420	1.04613293
47	Tryptophan metabolism_Homo sapiens_hsa00380	1.02138127
48	Non-homologous end-joining_Homo sapiens_hsa03450	0.99389549
49	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.97495696
50	Butanoate metabolism_Homo sapiens_hsa00650	0.97404192
51	DNA replication_Homo sapiens_hsa03030	0.95012393
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.92491172
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87770243
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.83527358
55	Caffeine metabolism_Homo sapiens_hsa00232	0.80990830
56	Base excision repair_Homo sapiens_hsa03410	0.78759227
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.77480953
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.77274178
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.77090949
60	Viral myocarditis_Homo sapiens_hsa05416	0.73945578
61	Regulation of autophagy_Homo sapiens_hsa04140	0.73332018
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72016555
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70237070
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69798317
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.69591349
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.67525137
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64568492
68	Fatty acid elongation_Homo sapiens_hsa00062	0.63413705
69	Metabolic pathways_Homo sapiens_hsa01100	0.62259954
70	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.60177989
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.59762737
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58902840
73	Retinol metabolism_Homo sapiens_hsa00830	0.57210553
74	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56918196
75	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.55944256
76	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53546699
77	Glutathione metabolism_Homo sapiens_hsa00480	0.52991172
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50793793
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49583279
80	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.48578019
81	Alcoholism_Homo sapiens_hsa05034	0.46765283
82	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45028749
83	Olfactory transduction_Homo sapiens_hsa04740	0.44240590
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44030072
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.43920329
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39641598
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.39342359
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.37173990
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36993334
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.35313973
91	Herpes simplex infection_Homo sapiens_hsa05168	0.35277069
92	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.33716291
93	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32684169
94	Nicotine addiction_Homo sapiens_hsa05033	0.32016870
95	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31501131
96	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.31385310
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27668950
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.27130972
99	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26378913
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.25293077

EEF1A1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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