EEF1A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.78786604
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42356529
3locomotory exploration behavior (GO:0035641)5.29709828
4muscle filament sliding (GO:0030049)5.14756707
5actin-myosin filament sliding (GO:0033275)5.14756707
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.86754370
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76939835
8cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.74566105
9skeletal muscle contraction (GO:0003009)4.68820126
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.63298162
11vocalization behavior (GO:0071625)4.61548355
12neuronal action potential propagation (GO:0019227)4.49017208
13regulation of synapse structural plasticity (GO:0051823)4.47699505
14glutamate secretion (GO:0014047)4.47557707
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.45549877
16synaptic vesicle exocytosis (GO:0016079)4.41127599
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.33749748
18cell communication by electrical coupling (GO:0010644)4.32376163
19regulation of synaptic vesicle exocytosis (GO:2000300)4.31770481
20sodium ion export (GO:0071436)4.31270046
21positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.13937316
22cellular potassium ion homeostasis (GO:0030007)4.11846602
23regulation of glutamate receptor signaling pathway (GO:1900449)4.10691777
24regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.08284199
25actin-mediated cell contraction (GO:0070252)4.05393819
26cerebellar granule cell differentiation (GO:0021707)4.03747218
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.01654808
28response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.00216889
29regulation of synaptic vesicle transport (GO:1902803)4.00135328
30regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.96219210
31neurotransmitter secretion (GO:0007269)3.95176573
32plasma membrane repair (GO:0001778)3.92064104
33creatine metabolic process (GO:0006600)3.87530684
34activation of protein kinase A activity (GO:0034199)3.83457657
35regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.83148327
36potassium ion import (GO:0010107)3.82202628
37regulation of neuronal synaptic plasticity (GO:0048168)3.81679207
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.81013340
39cytoskeletal anchoring at plasma membrane (GO:0007016)3.77493802
40cell communication involved in cardiac conduction (GO:0086065)3.76716431
41NADH metabolic process (GO:0006734)3.75368843
42exploration behavior (GO:0035640)3.75067315
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.74998156
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74709390
45layer formation in cerebral cortex (GO:0021819)3.72917328
46negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.72832159
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.68183337
48negative regulation of potassium ion transmembrane transport (GO:1901380)3.65157771
49regulation of membrane repolarization (GO:0060306)3.64814579
50positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.63195119
51gamma-aminobutyric acid transport (GO:0015812)3.58736743
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.54594358
53protein localization to synapse (GO:0035418)3.54371208
54membrane depolarization during action potential (GO:0086010)3.49717969
55regulation of relaxation of muscle (GO:1901077)3.48595915
56regulation of cell communication by electrical coupling (GO:0010649)3.47900193
57dendritic spine morphogenesis (GO:0060997)3.47076184
58cardiac muscle contraction (GO:0060048)3.46271732
59regulation of calcium ion transmembrane transporter activity (GO:1901019)3.41875925
60regulation of calcium ion transmembrane transport (GO:1903169)3.41875925
61long-term memory (GO:0007616)3.40937873
62response to parathyroid hormone (GO:0071107)3.40871138
63positive regulation of potassium ion transmembrane transport (GO:1901381)3.39694795
64glycine transport (GO:0015816)3.37584237
65sarcoplasmic reticulum calcium ion transport (GO:0070296)3.37224553
66regulation of synapse maturation (GO:0090128)3.34757767
67proline transport (GO:0015824)3.34284053
68neuromuscular process controlling posture (GO:0050884)3.33373164
69neurotransmitter-gated ion channel clustering (GO:0072578)3.29814710
70synaptic transmission, glutamatergic (GO:0035249)3.29646808
71neuromuscular process controlling balance (GO:0050885)3.29097899
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.24321955
73cardiac myofibril assembly (GO:0055003)3.19712338
74skeletal muscle adaptation (GO:0043501)3.19039476
75sarcomere organization (GO:0045214)3.18551466
76glutamate receptor signaling pathway (GO:0007215)3.17685693
77cerebellar Purkinje cell differentiation (GO:0021702)3.17061745
78actomyosin structure organization (GO:0031032)3.16161302
79regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15551012
80actin filament-based movement (GO:0030048)3.14105080
81negative regulation of cell size (GO:0045792)3.14048417
82regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.13955643
83regulation of voltage-gated calcium channel activity (GO:1901385)3.12142818
84neurotransmitter transport (GO:0006836)3.11458078
85positive regulation of membrane potential (GO:0045838)3.09038279
86neuron-neuron synaptic transmission (GO:0007270)3.07238130
87cardiac muscle hypertrophy (GO:0003300)3.06339995
88regulation of dendritic spine morphogenesis (GO:0061001)3.06130902
89detection of calcium ion (GO:0005513)3.04699847
90potassium ion homeostasis (GO:0055075)3.02883590
91regulation of ARF protein signal transduction (GO:0032012)3.01964692
92negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01614077
93membrane repolarization (GO:0086009)2.99134376
94cell-substrate adherens junction assembly (GO:0007045)2.96702722
95focal adhesion assembly (GO:0048041)2.96702722
96adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96549414
97regulation of postsynaptic membrane potential (GO:0060078)2.96495467
98regulation of actin filament-based movement (GO:1903115)2.96416484
99regulation of ion transmembrane transporter activity (GO:0032412)2.95161816
100positive regulation of potassium ion transport (GO:0043268)2.94483917
101regulation of neurotransmitter levels (GO:0001505)2.92686561
102muscle contraction (GO:0006936)2.91667202
103regulation of synaptic plasticity (GO:0048167)2.91306412
104myofibril assembly (GO:0030239)2.91207696
105neuronal ion channel clustering (GO:0045161)2.90908705
106cerebellar Purkinje cell layer development (GO:0021680)2.90795172
107cardiac conduction (GO:0061337)2.90504202
108gluconeogenesis (GO:0006094)2.88476897
109striated muscle hypertrophy (GO:0014897)2.87956671
110regulation of cation channel activity (GO:2001257)2.87618804
111neuromuscular synaptic transmission (GO:0007274)2.87468756
112membrane depolarization (GO:0051899)2.87260468
113neuron cell-cell adhesion (GO:0007158)2.87041583
114cellular sodium ion homeostasis (GO:0006883)2.86863989
115striated muscle contraction (GO:0006941)2.86852707
116regulation of neurotransmitter secretion (GO:0046928)2.86550462
117regulation of transmembrane transporter activity (GO:0022898)2.85788829
118positive regulation of sodium ion transport (GO:0010765)2.85708037
119positive regulation of synapse maturation (GO:0090129)2.84983427
120striated muscle adaptation (GO:0014888)2.84047390
121regulation of skeletal muscle contraction (GO:0014819)2.82946423
122prepulse inhibition (GO:0060134)2.82814890
123auditory behavior (GO:0031223)2.82756112
124cell migration in hindbrain (GO:0021535)2.82070959
125vesicle transport along microtubule (GO:0047496)2.81759341
126adherens junction assembly (GO:0034333)2.79349963
127synaptic vesicle endocytosis (GO:0048488)2.76054819
128regulation of the force of heart contraction (GO:0002026)2.75878417
129skeletal muscle fiber development (GO:0048741)2.75687203
130membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.73573566
131G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.71476854
132muscle hypertrophy in response to stress (GO:0003299)2.69159793
133cardiac muscle adaptation (GO:0014887)2.69159793
134cardiac muscle hypertrophy in response to stress (GO:0014898)2.69159793
135striated muscle atrophy (GO:0014891)2.67061834
136hexose biosynthetic process (GO:0019319)2.65345521
137regulation of sodium ion transmembrane transporter activity (GO:2000649)2.64302252
138positive regulation of neurotransmitter secretion (GO:0001956)2.58056090
139muscle system process (GO:0003012)2.57670257
140regulation of sodium ion transmembrane transport (GO:1902305)2.57352401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.65405768
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91015688
3* RARB_27405468_Chip-Seq_BRAIN_Mouse2.82510595
4* DROSHA_22980978_ChIP-Seq_HELA_Human2.82015782
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80616374
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69619711
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66580852
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66580852
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50768096
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.48664465
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.48344172
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.45988457
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42445980
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40423527
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34471865
16* RACK7_27058665_Chip-Seq_MCF-7_Human2.34314217
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29284890
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24165436
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23077847
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.20074830
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18760810
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16659360
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14344160
24GBX2_23144817_ChIP-Seq_PC3_Human2.12335306
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12141623
26* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.06401630
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.02553506
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.90029698
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88827618
30* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83557041
31* EED_16625203_ChIP-ChIP_MESCs_Mouse1.79819112
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69998407
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.68647151
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.64865434
35* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.64412270
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62599285
37AR_21572438_ChIP-Seq_LNCaP_Human1.60827325
38* TET1_21451524_ChIP-Seq_MESCs_Mouse1.59825678
39* CREB1_26743006_Chip-Seq_LNCaP_Human1.59565926
40* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58329909
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57676233
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56184264
43KDM2B_26808549_Chip-Seq_K562_Human1.55550039
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.53464780
45TCF7_22412390_ChIP-Seq_EML_Mouse1.52790852
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52734585
47* P68_20966046_ChIP-Seq_HELA_Human1.52631882
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50434337
49* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47411465
50* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46953742
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46376636
52* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45891055
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.44779675
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43129210
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39304053
56* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36493132
57ESR1_20079471_ChIP-ChIP_T-47D_Human1.32360604
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31714431
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.31132444
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30577380
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29203599
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28577264
63ZNF274_21170338_ChIP-Seq_K562_Hela1.28011883
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25822388
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25265855
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24878439
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24630512
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23917575
69SMAD4_21799915_ChIP-Seq_A2780_Human1.23842599
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23454133
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.22878699
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20786262
73* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.20440163
74CTCF_27219007_Chip-Seq_Bcells_Human1.19776037
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18268868
76* AR_19668381_ChIP-Seq_PC3_Human1.17804617
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17663831
78SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16974640
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16924105
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15889927
81TP53_20018659_ChIP-ChIP_R1E_Mouse1.15325480
82TP63_17297297_ChIP-ChIP_HaCaT_Human1.15161228
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13991114
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.10226301
85STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08001334
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06954662
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.06200505
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06039587
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04153667
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.03908124
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02622620
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02489999
93LXR_22292898_ChIP-Seq_THP-1_Human1.02102241
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01492652
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01319255
96TET1_21490601_ChIP-Seq_MESCs_Mouse1.00983079
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00670628
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.00071396
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99987911
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99482406
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99446874
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99212776
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98942098
104ZNF263_19887448_ChIP-Seq_K562_Human0.98850941
105CLOCK_20551151_ChIP-Seq_293T_Human0.98377877
106KDM2B_26808549_Chip-Seq_DND41_Human0.98367936
107TBX20_22328084_ChIP-Seq_HEART_Mouse0.97522636
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.97522636
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97262705
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.97058845
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96985595
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.96755809
113* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95601864
114KLF4_19829295_ChIP-Seq_ESCs_Human0.95137490
115CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94451776
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94365429
117* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92270914
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92027065
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91763478
120* SMC4_20622854_ChIP-Seq_HELA_Human0.91212337
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91067802
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91029226
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90781304
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90395766
125CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90048258
126STAT3_23295773_ChIP-Seq_U87_Human0.89069415
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88984752
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88883070
129EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88621086
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87770813
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87598005
132AR_25329375_ChIP-Seq_VCAP_Human0.86522844
133AHR_22903824_ChIP-Seq_MCF-7_Human0.86472709
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86127983
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85971313
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85899085
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.85140795
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.84825452
139OCT4_19829295_ChIP-Seq_ESCs_Human0.83979636
140SMAD3_21741376_ChIP-Seq_EPCs_Human0.83691395
141RXR_22108803_ChIP-Seq_LS180_Human0.82414819
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.81599231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.88631739
2MP0002837_dystrophic_cardiac_calcinosis3.51960754
3MP0000751_myopathy3.49453510
4* MP0003635_abnormal_synaptic_transmissio3.47587906
5MP0003880_abnormal_central_pattern3.38980013
6MP0003646_muscle_fatigue3.38144593
7MP0004270_analgesia3.19091435
8MP0009745_abnormal_behavioral_response2.78599366
9MP0002822_catalepsy2.73949630
10MP0009046_muscle_twitch2.71213896
11MP0002063_abnormal_learning/memory/cond2.64417973
12MP0002064_seizures2.62309764
13MP0004145_abnormal_muscle_electrophysio2.57858748
14MP0004215_abnormal_myocardial_fiber2.57097316
15MP0005451_abnormal_body_composition2.42301052
16MP0004084_abnormal_cardiac_muscle2.41268841
17MP0004036_abnormal_muscle_relaxation2.27814621
18MP0001968_abnormal_touch/_nociception2.27571549
19MP0005423_abnormal_somatic_nervous2.24979783
20MP0002272_abnormal_nervous_system2.24391153
21MP0003123_paternal_imprinting2.23277656
22MP0000749_muscle_degeneration2.19960636
23MP0002734_abnormal_mechanical_nocicepti2.12021704
24MP0008569_lethality_at_weaning2.10278962
25MP0002572_abnormal_emotion/affect_behav2.08767086
26MP0001486_abnormal_startle_reflex1.99483586
27MP0003705_abnormal_hypodermis_morpholog1.94141789
28MP0002909_abnormal_adrenal_gland1.93648437
29MP0003137_abnormal_impulse_conducting1.81974818
30MP0004858_abnormal_nervous_system1.79501076
31MP0004130_abnormal_muscle_cell1.75250354
32MP0009780_abnormal_chondrocyte_physiolo1.74967050
33MP0001501_abnormal_sleep_pattern1.73225525
34MP0010234_abnormal_vibrissa_follicle1.70862398
35MP0000747_muscle_weakness1.69320456
36MP0005330_cardiomyopathy1.68456687
37MP0003329_amyloid_beta_deposits1.68402130
38MP0001440_abnormal_grooming_behavior1.68244495
39MP0002735_abnormal_chemical_nociception1.67681838
40MP0004087_abnormal_muscle_fiber1.66679782
41MP0002736_abnormal_nociception_after1.63340414
42MP0005620_abnormal_muscle_contractility1.61441280
43MP0004484_altered_response_of1.60473197
44MP0002067_abnormal_sensory_capabilities1.57896143
45MP0001970_abnormal_pain_threshold1.57433758
46MP0002733_abnormal_thermal_nociception1.54730331
47MP0004085_abnormal_heartbeat1.52331390
48MP0002972_abnormal_cardiac_muscle1.51868636
49MP0002106_abnormal_muscle_physiology1.49362812
50MP0004924_abnormal_behavior1.49145681
51MP0005386_behavior/neurological_phenoty1.49145681
52MP0004811_abnormal_neuron_physiology1.47888247
53MP0004233_abnormal_muscle_weight1.46709993
54MP0002269_muscular_atrophy1.41599888
55MP0001348_abnormal_lacrimal_gland1.40074067
56MP0000733_abnormal_muscle_development1.37460442
57MP0004185_abnormal_adipocyte_glucose1.36461823
58MP0004510_myositis1.36071099
59MP0002249_abnormal_larynx_morphology1.34305211
60MP0003633_abnormal_nervous_system1.31891387
61MP0000759_abnormal_skeletal_muscle1.28416585
62MP0000579_abnormal_nail_morphology1.25170613
63MP0008775_abnormal_heart_ventricle1.23065581
64MP0002557_abnormal_social/conspecific_i1.22220911
65* MP0002066_abnormal_motor_capabilities/c1.21672751
66MP0008961_abnormal_basal_metabolism1.18668030
67* MP0002184_abnormal_innervation1.17941322
68MP0004885_abnormal_endolymph1.17872454
69MP0003879_abnormal_hair_cell1.17545536
70* MP0005369_muscle_phenotype1.17452148
71MP0000013_abnormal_adipose_tissue1.15297384
72* MP0000955_abnormal_spinal_cord1.14221354
73MP0000537_abnormal_urethra_morphology1.12435832
74MP0001346_abnormal_lacrimal_gland1.11423970
75MP0005385_cardiovascular_system_phenoty1.06347114
76MP0001544_abnormal_cardiovascular_syste1.06347114
77MP0006138_congestive_heart_failure1.05702888
78MP0000750_abnormal_muscle_regeneration1.05097153
79* MP0002882_abnormal_neuron_morphology1.04850981
80MP0003631_nervous_system_phenotype1.03739985
81MP0005646_abnormal_pituitary_gland1.01915721
82MP0004142_abnormal_muscle_tone1.01876046
83MP0000778_abnormal_nervous_system1.00740947
84MP0005167_abnormal_blood-brain_barrier1.00272924
85MP0003075_altered_response_to0.99897908
86MP0005409_darkened_coat_color0.99410130
87MP0005666_abnormal_adipose_tissue0.97981879
88MP0005076_abnormal_cell_differentiation0.97014793
89MP0000003_abnormal_adipose_tissue0.94906886
90MP0008874_decreased_physiological_sensi0.93111117
91MP0010630_abnormal_cardiac_muscle0.92036226
92MP0009672_abnormal_birth_weight0.90753312
93MP0005623_abnormal_meninges_morphology0.90572886
94MP0003690_abnormal_glial_cell0.89550721
95MP0001502_abnormal_circadian_rhythm0.89291888
96MP0000462_abnormal_digestive_system0.89071779
97MP0005375_adipose_tissue_phenotype0.88867809
98MP0005535_abnormal_body_temperature0.88325540
99MP0004043_abnormal_pH_regulation0.87424280
100MP0001984_abnormal_olfaction0.87192427
101MP0003283_abnormal_digestive_organ0.87094814
102MP0006276_abnormal_autonomic_nervous0.85254808
103MP0005670_abnormal_white_adipose0.79415134
104MP0002234_abnormal_pharynx_morphology0.77801614
105MP0002332_abnormal_exercise_endurance0.76102361
106MP0000534_abnormal_ureter_morphology0.75994313
107* MP0002229_neurodegeneration0.75981042
108* MP0002152_abnormal_brain_morphology0.73282075
109MP0008872_abnormal_physiological_respon0.72933806
110MP0002796_impaired_skin_barrier0.71050366
111MP0002127_abnormal_cardiovascular_syste0.70396872
112MP0002069_abnormal_eating/drinking_beha0.68666031
113* MP0000920_abnormal_myelination0.68165137
114MP0005645_abnormal_hypothalamus_physiol0.67039751
115MP0001905_abnormal_dopamine_level0.65656399
116MP0000604_amyloidosis0.65447143
117MP0003632_abnormal_nervous_system0.65236745
118MP0001529_abnormal_vocalization0.65041514
119MP0003787_abnormal_imprinting0.64283262
120MP0006036_abnormal_mitochondrial_physio0.63748534
121* MP0003634_abnormal_glial_cell0.63074738
122* MP0002108_abnormal_muscle_morphology0.61561233
123MP0002090_abnormal_vision0.61531054
124MP0003122_maternal_imprinting0.60592413
125MP0002089_abnormal_postnatal_growth/wei0.58832343

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.01350648
2Myokymia (HP:0002411)5.69772073
3Focal motor seizures (HP:0011153)5.37241807
4Exercise-induced myalgia (HP:0003738)4.86370611
5Sudden death (HP:0001699)4.84555252
6Visual hallucinations (HP:0002367)4.54116422
7Bundle branch block (HP:0011710)4.39176906
8Ventricular fibrillation (HP:0001663)4.33791076
9Exercise-induced muscle cramps (HP:0003710)4.21096457
10Focal seizures (HP:0007359)4.20953812
11Distal lower limb muscle weakness (HP:0009053)4.10834977
12Myopathic facies (HP:0002058)4.01543271
13Calf muscle hypertrophy (HP:0008981)4.01537028
14Muscle hypertrophy of the lower extremities (HP:0008968)3.90859097
15Action tremor (HP:0002345)3.74997614
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.70247995
17Atrial fibrillation (HP:0005110)3.47769946
18Primary atrial arrhythmia (HP:0001692)3.35769517
19Myotonia (HP:0002486)3.34967799
20Prolonged QT interval (HP:0001657)3.31721753
21Distal arthrogryposis (HP:0005684)3.30782307
22Abnormality of the calf musculature (HP:0001430)3.28909848
23Hyporeflexia of lower limbs (HP:0002600)3.27617665
24Progressive cerebellar ataxia (HP:0002073)3.24848315
25Difficulty running (HP:0009046)3.21986883
26Syncope (HP:0001279)3.20110699
27Atonic seizures (HP:0010819)3.19674466
28Supraventricular tachycardia (HP:0004755)3.18886059
29Dysmetric saccades (HP:0000641)3.17009050
30Ankle clonus (HP:0011448)3.12235526
31Muscle fiber splitting (HP:0003555)3.10890263
32Supraventricular arrhythmia (HP:0005115)3.10318609
33Heart block (HP:0012722)3.06857824
34Round ear (HP:0100830)3.05438243
35Febrile seizures (HP:0002373)3.02361485
36Abnormal EKG (HP:0003115)3.01879245
37Depression (HP:0000716)3.00656371
38Myoglobinuria (HP:0002913)3.00328719
39Generalized tonic-clonic seizures (HP:0002069)3.00301984
40Poor eye contact (HP:0000817)2.99879594
41Distal lower limb amyotrophy (HP:0008944)2.96536698
42Absence seizures (HP:0002121)2.95068416
43EMG: myopathic abnormalities (HP:0003458)2.93538452
44Ventricular arrhythmia (HP:0004308)2.91795433
45Supranuclear gaze palsy (HP:0000605)2.91118126
46Epileptic encephalopathy (HP:0200134)2.90001574
47Dysdiadochokinesis (HP:0002075)2.88760500
48Neck muscle weakness (HP:0000467)2.87913013
49Ventricular tachycardia (HP:0004756)2.86983810
50Postural instability (HP:0002172)2.85534790
51Abnormal atrioventricular conduction (HP:0005150)2.83117599
52Impaired vibration sensation in the lower limbs (HP:0002166)2.82067625
53Subaortic stenosis (HP:0001682)2.80122016
54Abnormality of the left ventricular outflow tract (HP:0011103)2.80122016
55Impaired social interactions (HP:0000735)2.79971022
56Abnormal social behavior (HP:0012433)2.79971022
57Rhabdomyolysis (HP:0003201)2.78560921
58Ulnar deviation of the wrist (HP:0003049)2.77533227
59Anxiety (HP:0000739)2.74072700
60Mildly elevated creatine phosphokinase (HP:0008180)2.73370331
61Broad-based gait (HP:0002136)2.70777718
62Urinary bladder sphincter dysfunction (HP:0002839)2.67576097
63Obstructive sleep apnea (HP:0002870)2.66695803
64Pheochromocytoma (HP:0002666)2.66272586
65Dialeptic seizures (HP:0011146)2.62302367
66Dysmetria (HP:0001310)2.62099034
67Atrioventricular block (HP:0001678)2.61495180
68Urinary urgency (HP:0000012)2.61367510
69Gaze-evoked nystagmus (HP:0000640)2.60921317
70Bulbar palsy (HP:0001283)2.57547177
71Abnormality of the lower motor neuron (HP:0002366)2.53810308
72Areflexia of lower limbs (HP:0002522)2.48661634
73Frequent falls (HP:0002359)2.45865554
74Hyperacusis (HP:0010780)2.43496580
75Increased variability in muscle fiber diameter (HP:0003557)2.39506889
76Hemiplegia (HP:0002301)2.38851323
77Lower limb amyotrophy (HP:0007210)2.35703161
78Muscle stiffness (HP:0003552)2.33602376
79Progressive muscle weakness (HP:0003323)2.31666223
80Asymmetric septal hypertrophy (HP:0001670)2.28520112
81Truncal ataxia (HP:0002078)2.27330001
82Neuroendocrine neoplasm (HP:0100634)2.25532603
83Rapidly progressive (HP:0003678)2.25259446
84Genetic anticipation (HP:0003743)2.24422764
85Papilledema (HP:0001085)2.23463870
86Intention tremor (HP:0002080)2.23089910
87Fetal akinesia sequence (HP:0001989)2.21529907
88Annular pancreas (HP:0001734)2.18899685
89Rimmed vacuoles (HP:0003805)2.17781332
90Calcaneovalgus deformity (HP:0001848)2.17406425
91Muscle fiber inclusion bodies (HP:0100299)2.17318143
92Ragged-red muscle fibers (HP:0003200)2.14383615
93Abnormality of skeletal muscle fiber size (HP:0012084)2.13855466
94Difficulty climbing stairs (HP:0003551)2.13107795
95Mutism (HP:0002300)2.12500713
96Torticollis (HP:0000473)2.07493281
97Abnormal eating behavior (HP:0100738)2.06659294
98Dilated cardiomyopathy (HP:0001644)2.06400586
99Palpitations (HP:0001962)2.05426139
100Lipoatrophy (HP:0100578)2.04905826
101Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04738257
102Impaired smooth pursuit (HP:0007772)2.02365901
103Scanning speech (HP:0002168)2.02143175
104Resting tremor (HP:0002322)2.01813656
105Akinesia (HP:0002304)1.99568214
106Hypercortisolism (HP:0001578)1.99116176
107Spastic gait (HP:0002064)1.98598015
108Tetraplegia (HP:0002445)1.98337038
109Increased connective tissue (HP:0009025)1.97671195
110Bradykinesia (HP:0002067)1.96632068
111EMG: neuropathic changes (HP:0003445)1.96459887
112Type 1 muscle fiber predominance (HP:0003803)1.95491269
113Cerebral inclusion bodies (HP:0100314)1.95093204
114Scapular winging (HP:0003691)1.95031030
115Right ventricular cardiomyopathy (HP:0011663)1.94608971
116Lower limb muscle weakness (HP:0007340)1.94259575
117Left ventricular hypertrophy (HP:0001712)1.93726836
118Testicular atrophy (HP:0000029)1.92939913
119Insomnia (HP:0100785)1.92923424
120Progressive inability to walk (HP:0002505)1.92214650
121Central scotoma (HP:0000603)1.91334149
122Foot dorsiflexor weakness (HP:0009027)1.91288059
123Neoplasm of the peripheral nervous system (HP:0100007)1.91190719
124Abnormality of the foot musculature (HP:0001436)1.88241836
125Focal dystonia (HP:0004373)1.87900544
126Amblyopia (HP:0000646)1.86862702
127Impaired vibratory sensation (HP:0002495)1.86671627
128Termporal pattern (HP:0011008)1.86539825
129Absent phalangeal crease (HP:0006109)1.81833432
130Deformed tarsal bones (HP:0008119)1.80731693
131Achilles tendon contracture (HP:0001771)1.79229834
132Generalized muscle weakness (HP:0003324)1.74978839
133J-shaped sella turcica (HP:0002680)1.73092454
134Upper limb amyotrophy (HP:0009129)1.71135123
135Distal upper limb amyotrophy (HP:0007149)1.71135123
136Slow progression (HP:0003677)1.70457740
137Hyperthyroidism (HP:0000836)1.70411576
138Malignant hyperthermia (HP:0002047)1.68046428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.45497919
2NTRK33.43956579
3EPHA43.38506192
4PHKG22.84983853
5PHKG12.84983853
6PRKD32.51951418
7MAP3K42.44334856
8LMTK22.43485732
9PAK62.39831943
10EEF2K2.37021396
11DAPK22.32338124
12SIK12.31120535
13MINK12.28663674
14KSR22.19783170
15CAMKK12.06570663
16PINK12.03397164
17MARK11.99754476
18TTN1.93833368
19STK381.89662295
20SCYL21.88212505
21SMG11.85794173
22MAP2K41.81955781
23MAPKAPK31.79682719
24EPHA21.75697887
25NEK11.74254540
26OBSCN1.65158024
27NTRK11.63494689
28NTRK21.60061965
29MAP2K71.59157126
30RPS6KB21.53887568
31DMPK1.49664206
32RIPK11.41575619
33TRIB31.34464816
34TAOK11.33100460
35CDK51.31973699
36PDK41.27926255
37PDK31.27926255
38LIMK11.22846851
39TESK11.20175563
40NEK61.20165567
41RIPK41.16913301
42GRK51.14652495
43CAMK11.11456357
44TYRO31.11036125
45PRKCH1.10929025
46CAMKK21.10797644
47KSR11.08019698
48PAK31.07060023
49UHMK11.06543669
50MAP3K71.03646230
51LATS21.03206636
52IRAK31.01821549
53MAP3K120.98502223
54ALK0.98364460
55WNK10.97841912
56DAPK10.97438046
57MAP3K20.97125860
58STK110.97066788
59PKN20.95903336
60RET0.95897728
61MAP2K20.94186898
62CDK190.93609463
63ARAF0.93322854
64MUSK0.92814003
65PRKCG0.92088491
66PRPF4B0.89231337
67CAMK2A0.86170532
68SIK20.84583584
69PDK10.84237938
70SGK30.84172689
71CDC42BPA0.84070411
72CAMK1D0.82856322
73MAP3K130.82310749
74FES0.81853391
75SGK2230.81764404
76SGK4940.81764404
77PDPK10.80898595
78MAP2K10.78220814
79BRAF0.78192374
80CAMK2D0.75964389
81CAMK40.74919112
82PLK20.74803940
83NME20.74155815
84MAP3K10.73731833
85MTOR0.71365095
86BRSK10.68612676
87AKT20.68179315
88TNIK0.68097449
89SGK10.65601892
90SGK20.65075142
91CDK150.64291267
92PRKD10.63701594
93PTK2B0.63267506
94MAPK120.63167853
95MAP3K110.62797436
96CDK180.62114360
97MAPK130.62077402
98IRAK20.61539893
99PDK20.61462613
100DAPK30.60767845
101PRKCI0.60280650
102CAMK2G0.59828735
103PRKD20.58979827
104CDK140.57506931
105MARK20.56996211
106RPS6KA20.55733195
107ROCK10.55663829
108RPS6KA30.55588079
109RAF10.54657379
110CDK11A0.54393352
111NME10.53532279
112PDGFRA0.51033092
113CAMK2B0.50406380
114MYLK0.50232443
115PNCK0.50232063
116PTK20.50159394
117ROCK20.47810521
118PRKAA10.47265989
119TNK20.46574793
120CAMK1G0.45752143
121PIK3CA0.44293791
122TAOK20.40838654
123RPS6KB10.40410371
124PTK60.39808959
125MAPK100.38990185
126ILK0.38500712
127MAP2K60.38440600
128FER0.37549528
129ICK0.37389578
130CCNB10.36013320
131TESK20.35355993

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.67396338
2Nicotine addiction_Homo sapiens_hsa050332.65155741
3Olfactory transduction_Homo sapiens_hsa047402.51680212
4Circadian entrainment_Homo sapiens_hsa047132.40373055
5GABAergic synapse_Homo sapiens_hsa047272.28055335
6Long-term potentiation_Homo sapiens_hsa047202.27209286
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21666973
8Glutamatergic synapse_Homo sapiens_hsa047242.17112682
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.17083425
10Cardiac muscle contraction_Homo sapiens_hsa042602.15398596
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12185766
12Morphine addiction_Homo sapiens_hsa050322.03961704
13Gastric acid secretion_Homo sapiens_hsa049711.97472505
14Salivary secretion_Homo sapiens_hsa049701.94976925
15Amphetamine addiction_Homo sapiens_hsa050311.94826161
16Insulin secretion_Homo sapiens_hsa049111.92646084
17Dilated cardiomyopathy_Homo sapiens_hsa054141.91160897
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85744865
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78440752
20Nitrogen metabolism_Homo sapiens_hsa009101.75339580
21Dopaminergic synapse_Homo sapiens_hsa047281.74319968
22Oxytocin signaling pathway_Homo sapiens_hsa049211.73202033
23Cholinergic synapse_Homo sapiens_hsa047251.70966261
24Calcium signaling pathway_Homo sapiens_hsa040201.63570552
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61433803
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.50573830
27Renin secretion_Homo sapiens_hsa049241.50244444
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43472110
29GnRH signaling pathway_Homo sapiens_hsa049121.42196695
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40055555
31Taste transduction_Homo sapiens_hsa047421.39843763
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39793638
33Type II diabetes mellitus_Homo sapiens_hsa049301.38966093
34Pentose phosphate pathway_Homo sapiens_hsa000301.36182307
35Vitamin B6 metabolism_Homo sapiens_hsa007501.35198166
36Long-term depression_Homo sapiens_hsa047301.33995696
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33188018
38cAMP signaling pathway_Homo sapiens_hsa040241.26525482
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23843459
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.23485302
41Cocaine addiction_Homo sapiens_hsa050301.20372212
42Gap junction_Homo sapiens_hsa045401.20358249
43Biosynthesis of amino acids_Homo sapiens_hsa012301.17159956
44Arginine and proline metabolism_Homo sapiens_hsa003301.16743445
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15385868
46Fructose and mannose metabolism_Homo sapiens_hsa000511.08558729
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08216622
48Serotonergic synapse_Homo sapiens_hsa047261.08136741
49Estrogen signaling pathway_Homo sapiens_hsa049151.05051381
50Vascular smooth muscle contraction_Homo sapiens_hsa042701.00587733
51Glioma_Homo sapiens_hsa052140.98439600
52Glucagon signaling pathway_Homo sapiens_hsa049220.91771936
53Dorso-ventral axis formation_Homo sapiens_hsa043200.88335856
54Pancreatic secretion_Homo sapiens_hsa049720.87002340
55Melanogenesis_Homo sapiens_hsa049160.84666537
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.82275904
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82210678
58Insulin signaling pathway_Homo sapiens_hsa049100.78602577
59ErbB signaling pathway_Homo sapiens_hsa040120.77644188
60Prion diseases_Homo sapiens_hsa050200.77511762
61Thyroid cancer_Homo sapiens_hsa052160.75220024
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73151208
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72711529
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71644038
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70579594
66Oocyte meiosis_Homo sapiens_hsa041140.70228569
67VEGF signaling pathway_Homo sapiens_hsa043700.69528488
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69221397
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68853863
70Thyroid hormone synthesis_Homo sapiens_hsa049180.68540761
71Collecting duct acid secretion_Homo sapiens_hsa049660.67374756
72Bile secretion_Homo sapiens_hsa049760.66896687
73Phenylalanine metabolism_Homo sapiens_hsa003600.66124725
74Arginine biosynthesis_Homo sapiens_hsa002200.65716311
75Axon guidance_Homo sapiens_hsa043600.65607258
76mTOR signaling pathway_Homo sapiens_hsa041500.65482416
77MAPK signaling pathway_Homo sapiens_hsa040100.64630758
78Pyruvate metabolism_Homo sapiens_hsa006200.64618466
79Alzheimers disease_Homo sapiens_hsa050100.62863525
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.61499537
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58538625
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57197449
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55497918
84Circadian rhythm_Homo sapiens_hsa047100.55224607
85Choline metabolism in cancer_Homo sapiens_hsa052310.54774283
86Parkinsons disease_Homo sapiens_hsa050120.52794705
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52537892
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.52313080
89Endocytosis_Homo sapiens_hsa041440.49534585
90Inositol phosphate metabolism_Homo sapiens_hsa005620.49010744
91Insulin resistance_Homo sapiens_hsa049310.48391741
92Rap1 signaling pathway_Homo sapiens_hsa040150.47476439
93Fatty acid metabolism_Homo sapiens_hsa012120.46850675
94Carbon metabolism_Homo sapiens_hsa012000.46531944
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46132044
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.44724289
97Butanoate metabolism_Homo sapiens_hsa006500.43278414
98Propanoate metabolism_Homo sapiens_hsa006400.41466867
99AMPK signaling pathway_Homo sapiens_hsa041520.41015635
100Renal cell carcinoma_Homo sapiens_hsa052110.40607533
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.39785742
102Fatty acid biosynthesis_Homo sapiens_hsa000610.39535821
103Ras signaling pathway_Homo sapiens_hsa040140.39506117
104Non-small cell lung cancer_Homo sapiens_hsa052230.39198693
105Tight junction_Homo sapiens_hsa045300.38739319
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37592711
107Vibrio cholerae infection_Homo sapiens_hsa051100.35679218
108HIF-1 signaling pathway_Homo sapiens_hsa040660.35394785
109Galactose metabolism_Homo sapiens_hsa000520.35188504
110Chronic myeloid leukemia_Homo sapiens_hsa052200.34503027
111Endometrial cancer_Homo sapiens_hsa052130.33925335
112Ovarian steroidogenesis_Homo sapiens_hsa049130.32337313
113Platelet activation_Homo sapiens_hsa046110.32189338
114Focal adhesion_Homo sapiens_hsa045100.32160968
115Oxidative phosphorylation_Homo sapiens_hsa001900.31224857

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