ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.95493889
2	ATP synthesis coupled proton transport (GO:0015986)	5.60994785
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.60994785
4	proteasome assembly (GO:0043248)	5.36158684
5	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.79933321
6	termination of RNA polymerase III transcription (GO:0006386)	4.79933321
7	7-methylguanosine mRNA capping (GO:0006370)	4.77499591
8	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	4.76271970
9	maturation of SSU-rRNA (GO:0030490)	4.75117068
10	RNA capping (GO:0036260)	4.67950223
11	7-methylguanosine RNA capping (GO:0009452)	4.67950223
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.51484932
13	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	4.49282210
14	cullin deneddylation (GO:0010388)	4.44025778
15	protein neddylation (GO:0045116)	4.39690329
16	regulation of cellular amino acid metabolic process (GO:0006521)	4.37888931
17	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	4.35422517
18	ribosomal small subunit biogenesis (GO:0042274)	4.34182671
19	cytochrome complex assembly (GO:0017004)	4.33435539
20	negative regulation of ligase activity (GO:0051352)	4.31736599
21	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	4.31736599
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.27333767
23	DNA deamination (GO:0045006)	4.25366365
24	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	4.25299066
25	ribosomal small subunit assembly (GO:0000028)	4.22496104
26	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	4.20208900
27	protein deneddylation (GO:0000338)	4.18736513
28	chaperone-mediated protein transport (GO:0072321)	4.16365755
29	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	4.11850047
30	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	4.11850047
31	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	4.09386382
32	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	4.09386382
33	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	4.09386382
34	ribosomal large subunit biogenesis (GO:0042273)	4.06111994
35	GTP biosynthetic process (GO:0006183)	4.03748027
36	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	4.00463277
37	respiratory electron transport chain (GO:0022904)	3.98269137
38	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.95864718
39	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.95864718
40	formation of translation preinitiation complex (GO:0001731)	3.94671150
41	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.92925356
42	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.92925356
43	NADH dehydrogenase complex assembly (GO:0010257)	3.92925356
44	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.91059033
45	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.90789926
46	electron transport chain (GO:0022900)	3.89661976
47	protein complex biogenesis (GO:0070271)	3.83885434
48	guanosine-containing compound biosynthetic process (GO:1901070)	3.83482567
49	viral transcription (GO:0019083)	3.82615215
50	termination of RNA polymerase I transcription (GO:0006363)	3.81527595
51	rRNA modification (GO:0000154)	3.80610211
52	establishment of integrated proviral latency (GO:0075713)	3.80468667
53	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.79746775
54	translational termination (GO:0006415)	3.79620974
55	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.78871930
56	inner mitochondrial membrane organization (GO:0007007)	3.76642768
57	water-soluble vitamin biosynthetic process (GO:0042364)	3.75459871
58	positive regulation of ligase activity (GO:0051351)	3.73036056
59	ribonucleoprotein complex biogenesis (GO:0022613)	3.70941104
60	maturation of 5.8S rRNA (GO:0000460)	3.69869351
61	protein targeting to mitochondrion (GO:0006626)	3.68873820
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.67707381
63	establishment of protein localization to mitochondrion (GO:0072655)	3.67122761
64	translation (GO:0006412)	3.61633833
65	mitochondrial respiratory chain complex assembly (GO:0033108)	3.59521999
66	UTP biosynthetic process (GO:0006228)	3.58181470
67	regulation of mitochondrial translation (GO:0070129)	3.58060717
68	peptidyl-histidine modification (GO:0018202)	3.57075948
69	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.56298751
70	cotranslational protein targeting to membrane (GO:0006613)	3.56042428
71	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.55999713
72	spliceosomal snRNP assembly (GO:0000387)	3.53203444
73	hydrogen ion transmembrane transport (GO:1902600)	3.52922294
74	transcription from RNA polymerase I promoter (GO:0006360)	3.52859907
75	transcription-coupled nucleotide-excision repair (GO:0006283)	3.52543782
76	ATP biosynthetic process (GO:0006754)	3.52466075
77	cellular component biogenesis (GO:0044085)	3.50928429
78	protein targeting to ER (GO:0045047)	3.49092626
79	purine nucleobase biosynthetic process (GO:0009113)	3.46649530
80	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.45636481
81	establishment of viral latency (GO:0019043)	3.45221566
82	nucleobase biosynthetic process (GO:0046112)	3.44752993
83	rRNA processing (GO:0006364)	3.43483998
84	CENP-A containing nucleosome assembly (GO:0034080)	3.40208426
85	translational initiation (GO:0006413)	3.39528889
86	regulation of ubiquitin-protein transferase activity (GO:0051438)	3.38615482
87	ribosome biogenesis (GO:0042254)	3.37914133
88	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.37061200
89	protein localization to mitochondrion (GO:0070585)	3.36286039
90	protein localization to endoplasmic reticulum (GO:0070972)	3.36122758
91	pseudouridine synthesis (GO:0001522)	3.34440464
92	chromatin remodeling at centromere (GO:0031055)	3.34328713
93	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.33822886
94	viral life cycle (GO:0019058)	3.33783072
95	translational elongation (GO:0006414)	3.33645766
96	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.32920292
97	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.32920292
98	protein-cofactor linkage (GO:0018065)	3.31229094
99	aldehyde catabolic process (GO:0046185)	3.30233137
100	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.29807626
101	regulation of cellular amine metabolic process (GO:0033238)	3.29417225
102	rRNA metabolic process (GO:0016072)	3.29125065
103	positive regulation of cell cycle arrest (GO:0071158)	3.28229553
104	protein K6-linked ubiquitination (GO:0085020)	3.27625337
105	regulation of ligase activity (GO:0051340)	3.26002500
106	telomere maintenance via semi-conservative replication (GO:0032201)	3.25043381
107	transcription elongation from RNA polymerase II promoter (GO:0006368)	3.20379749
108	positive regulation of viral transcription (GO:0050434)	3.20152622
109	intracellular protein transmembrane import (GO:0044743)	3.18664882
110	respiratory chain complex IV assembly (GO:0008535)	3.17071846
111	cellular protein complex disassembly (GO:0043624)	3.16567086
112	DNA damage response, signal transduction by p53 class mediator (GO:0030330)	3.16062777
113	DNA double-strand break processing (GO:0000729)	3.15838597
114	proton transport (GO:0015992)	3.15565784
115	DNA strand elongation involved in DNA replication (GO:0006271)	3.14498695
116	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13210411
117	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.11444166
118	hydrogen transport (GO:0006818)	3.10225770
119	DNA damage response, detection of DNA damage (GO:0042769)	3.10131013
120	spliceosomal complex assembly (GO:0000245)	3.08110002
121	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.03248778
122	rRNA methylation (GO:0031167)	3.02946469
123	organelle disassembly (GO:1903008)	2.89779457
124	mitochondrial transport (GO:0006839)	2.87597318
125	oxidative phosphorylation (GO:0006119)	2.85194789
126	mannosylation (GO:0097502)	2.84993665
127	nucleoside triphosphate biosynthetic process (GO:0009142)	2.81581040
128	tRNA processing (GO:0008033)	2.79606821

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	5.21515303
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.64967724
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.45437952
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	4.31028247
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.25171953
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.11003825
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.89290038
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.88516950
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.69746298
10	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.51963318
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.49167087
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.46855234
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.35056849
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.11505009
15	E2F7_22180533_ChIP-Seq_HELA_Human	3.11362948
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.10645390
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.08276162
18	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.81573660
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.73620477
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.70058948
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61387216
22	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.46320546
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.41107939
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.37994574
25	DCP1A_22483619_ChIP-Seq_HELA_Human	2.37478329
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.31310656
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.29556352
28	XRN2_22483619_ChIP-Seq_HELA_Human	2.28729148
29	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.24416602
30	ELK1_19687146_ChIP-ChIP_HELA_Human	2.24221911
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.20779147
32	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16265276
33	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.07398537
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.99887087
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.98531804
36	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.95254773
37	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.83446893
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.82487352
39	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.78863053
40	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.78212698
41	ZNF274_21170338_ChIP-Seq_K562_Hela	1.76580157
42	FUS_26573619_Chip-Seq_HEK293_Human	1.71753095
43	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.69940571
44	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.69754236
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69068502
46	EWS_26573619_Chip-Seq_HEK293_Human	1.67164825
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.62102547
48	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.61503281
49	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.59670659
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.57075762
51	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.55639543
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.55167871
53	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.48342271
54	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.46582079
55	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.46026451
56	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.44746905
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.41550819
58	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.37828812
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33776645
60	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.30346489
61	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.29607946
62	MYC_18940864_ChIP-ChIP_HL60_Human	1.27767641
63	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.22844204
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22003951
65	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.20692665
66	VDR_22108803_ChIP-Seq_LS180_Human	1.19016607
67	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17748297
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.16904084
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.16779174
70	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15256134
71	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.12515665
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12014538
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10979073
74	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.10724021
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09607301
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09589244
77	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09306615
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06773076
79	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.06623157
80	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06268876
81	TAF15_26573619_Chip-Seq_HEK293_Human	1.06072757
82	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05169803
83	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.04124746
84	P300_19829295_ChIP-Seq_ESCs_Human	1.04101578
85	CIITA_25753668_ChIP-Seq_RAJI_Human	1.04072351
86	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.99754894
87	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.99434571
88	GBX2_23144817_ChIP-Seq_PC3_Human	0.98102912
89	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.95403056
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.93968911
91	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93283905
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93283905
93	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.93201848
94	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.93006251
95	AR_21909140_ChIP-Seq_LNCAP_Human	0.90987316
96	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.90480443
97	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.90326352
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89432912
99	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.89351970
100	KDM5A_27292631_Chip-Seq_BREAST_Human	0.89036603
101	IGF1R_20145208_ChIP-Seq_DFB_Human	0.88271353
102	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.87819789
103	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.87732901
104	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.85705142
105	NANOG_19829295_ChIP-Seq_ESCs_Human	0.85493707
106	SOX2_19829295_ChIP-Seq_ESCs_Human	0.85493707
107	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.84483401
108	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.84428518
109	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.83283145
110	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.83212868
111	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.82664270
112	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.82551611
113	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.82094779
114	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.81757518
115	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.80381498
116	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.79882501
117	AR_20517297_ChIP-Seq_VCAP_Human	0.79601689
118	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.79501456
119	TFEB_21752829_ChIP-Seq_HELA_Human	0.79367826
120	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.79117473
121	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.77682502
122	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.77599502
123	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.77383525
124	CBP_20019798_ChIP-Seq_JUKART_Human	0.77383525
125	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.76928625
126	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.76856101
127	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.76352255
128	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.74908410
129	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.74660809
130	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.74273851
131	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.71346957
132	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.71301226
133	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.71276580
134	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.69837462
135	SPI1_23547873_ChIP-Seq_NB4_Human	0.69325263
136	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.67531384
137	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.66668236
138	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.65752973
139	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.65139820

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.79894940
2	MP0003693_abnormal_embryo_hatching	3.78386485
3	MP0006072_abnormal_retinal_apoptosis	3.02400868
4	MP0004957_abnormal_blastocyst_morpholog	2.99769478
5	MP0008058_abnormal_DNA_repair	2.95344417
6	MP0001529_abnormal_vocalization	2.92695787
7	MP0009379_abnormal_foot_pigmentation	2.84389794
8	MP0010094_abnormal_chromosome_stability	2.48237333
9	MP0008057_abnormal_DNA_replication	2.47263636
10	MP0003786_premature_aging	2.26921674
11	MP0003077_abnormal_cell_cycle	2.25852422
12	MP0008932_abnormal_embryonic_tissue	2.25388455
13	MP0003111_abnormal_nucleus_morphology	2.18125907
14	MP0003011_delayed_dark_adaptation	2.15972004
15	MP0006276_abnormal_autonomic_nervous	2.09991051
16	MP0002102_abnormal_ear_morphology	2.08608902
17	MP0003718_maternal_effect	2.04380342
18	MP0003123_paternal_imprinting	2.02759807
19	MP0002163_abnormal_gland_morphology	2.00256776
20	MP0006292_abnormal_olfactory_placode	1.98601301
21	MP0001188_hyperpigmentation	1.98413584
22	MP0001905_abnormal_dopamine_level	1.89172115
23	MP0003195_calcinosis	1.82242424
24	MP0001293_anophthalmia	1.81553737
25	MP0006035_abnormal_mitochondrial_morpho	1.81380635
26	MP0008877_abnormal_DNA_methylation	1.77679680
27	MP0000372_irregular_coat_pigmentation	1.76847093
28	MP0008260_abnormal_autophagy	1.73987801
29	MP0006036_abnormal_mitochondrial_physio	1.70211514
30	MP0003136_yellow_coat_color	1.67872460
31	MP0002736_abnormal_nociception_after	1.67860796
32	MP0003186_abnormal_redox_activity	1.64441567
33	MP0000631_abnormal_neuroendocrine_gland	1.60378984
34	MP0002234_abnormal_pharynx_morphology	1.57594391
35	MP0008007_abnormal_cellular_replicative	1.56371569
36	MP0002638_abnormal_pupillary_reflex	1.54852655
37	MP0001968_abnormal_touch/_nociception	1.53107184
38	MP0005253_abnormal_eye_physiology	1.49990974
39	MP0005075_abnormal_melanosome_morpholog	1.48951623
40	MP0002148_abnormal_hypersensitivity_rea	1.48692891
41	MP0002282_abnormal_trachea_morphology	1.48672074
42	MP0005551_abnormal_eye_electrophysiolog	1.47453107
43	MP0000569_abnormal_digit_pigmentation	1.45167079
44	MP0003283_abnormal_digestive_organ	1.40544923
45	MP0005646_abnormal_pituitary_gland	1.39756979
46	MP0002837_dystrophic_cardiac_calcinosis	1.37341559
47	MP0002938_white_spotting	1.34357888
48	MP0009333_abnormal_splenocyte_physiolog	1.32347942
49	MP0002160_abnormal_reproductive_system	1.30828960
50	MP0005174_abnormal_tail_pigmentation	1.29518325
51	MP0001727_abnormal_embryo_implantation	1.28773745
52	MP0001440_abnormal_grooming_behavior	1.26194850
53	MP0008875_abnormal_xenobiotic_pharmacok	1.25382825
54	MP0003315_abnormal_perineum_morphology	1.24036745
55	MP0003787_abnormal_imprinting	1.23917557
56	MP0004142_abnormal_muscle_tone	1.23232354
57	MP0004145_abnormal_muscle_electrophysio	1.22651207
58	MP0002876_abnormal_thyroid_physiology	1.19368444
59	MP0002928_abnormal_bile_duct	1.16880923
60	MP0004133_heterotaxia	1.16661889
61	MP0005671_abnormal_response_to	1.16249030
62	MP0002277_abnormal_respiratory_mucosa	1.13451343
63	MP0000750_abnormal_muscle_regeneration	1.12631520
64	MP0001986_abnormal_taste_sensitivity	1.12037310
65	MP0002132_abnormal_respiratory_system	1.11991237
66	MP0008872_abnormal_physiological_respon	1.10122991
67	MP0001542_abnormal_bone_strength	1.09559086
68	MP0003122_maternal_imprinting	1.06439480
69	MP0001835_abnormal_antigen_presentation	1.05859924
70	MP0008995_early_reproductive_senescence	1.04586161
71	MP0005645_abnormal_hypothalamus_physiol	1.03976644
72	MP0009780_abnormal_chondrocyte_physiolo	1.03909756
73	MP0010386_abnormal_urinary_bladder	1.02603532
74	MP0001853_heart_inflammation	1.01001725
75	MP0005379_endocrine/exocrine_gland_phen	1.00955354
76	MP0001286_abnormal_eye_development	1.00576422
77	MP0002735_abnormal_chemical_nociception	1.00285674
78	MP0009745_abnormal_behavioral_response	0.99532628
79	MP0009046_muscle_twitch	0.98942312
80	MP0002751_abnormal_autonomic_nervous	0.98194135
81	MP0002572_abnormal_emotion/affect_behav	0.98099119
82	MP0009785_altered_susceptibility_to	0.97847551
83	MP0003121_genomic_imprinting	0.97845751
84	MP0002064_seizures	0.97003991
85	MP0002272_abnormal_nervous_system	0.96837933
86	MP0003937_abnormal_limbs/digits/tail_de	0.96629935
87	MP0001984_abnormal_olfaction	0.95926655
88	MP0000647_abnormal_sebaceous_gland	0.95315277
89	MP0005389_reproductive_system_phenotype	0.93284100
90	MP0008789_abnormal_olfactory_epithelium	0.91188040
91	MP0003806_abnormal_nucleotide_metabolis	0.89076656
92	MP0002184_abnormal_innervation	0.88062544
93	MP0003941_abnormal_skin_development	0.86419075
94	MP0002095_abnormal_skin_pigmentation	0.85269676
95	MP0001929_abnormal_gametogenesis	0.84019450
96	MP0002734_abnormal_mechanical_nocicepti	0.83887064
97	MP0005332_abnormal_amino_acid	0.83570273
98	MP0004215_abnormal_myocardial_fiber	0.83424870
99	MP0005636_abnormal_mineral_homeostasis	0.83091467
100	MP0004885_abnormal_endolymph	0.82822562
101	MP0009697_abnormal_copulation	0.82463583
102	MP0000358_abnormal_cell_content/	0.82147396
103	MP0003646_muscle_fatigue	0.80973995
104	MP0002090_abnormal_vision	0.80571528
105	MP0000049_abnormal_middle_ear	0.80379270
106	MP0005367_renal/urinary_system_phenotyp	0.80316537
107	MP0000516_abnormal_urinary_system	0.80316537
108	MP0001730_embryonic_growth_arrest	0.79465786
109	MP0005391_vision/eye_phenotype	0.79242383
110	MP0003938_abnormal_ear_development	0.78915312
111	MP0005395_other_phenotype	0.78189228
112	MP0000013_abnormal_adipose_tissue	0.78074033
113	MP0002067_abnormal_sensory_capabilities	0.77769589
114	MP0003879_abnormal_hair_cell	0.77408015
115	MP0002063_abnormal_learning/memory/cond	0.77385169
116	MP0000350_abnormal_cell_proliferation	0.76670267
117	MP0004147_increased_porphyrin_level	0.75836856
118	MP0001970_abnormal_pain_threshold	0.75518047
119	MP0001485_abnormal_pinna_reflex	0.74182083
120	MP0000313_abnormal_cell_death	0.72912121
121	MP0000026_abnormal_inner_ear	0.72738087
122	MP0003635_abnormal_synaptic_transmissio	0.72635195
123	MP0004742_abnormal_vestibular_system	0.72156282
124	MP0005000_abnormal_immune_tolerance	0.71679003
125	MP0005499_abnormal_olfactory_system	0.71237321
126	MP0005394_taste/olfaction_phenotype	0.71237321
127	MP0001764_abnormal_homeostasis	0.70718404
128	MP0003763_abnormal_thymus_physiology	0.69985600
129	MP0005266_abnormal_metabolism	0.66577667
130	MP0002210_abnormal_sex_determination	0.65940428
131	MP0010030_abnormal_orbit_morphology	0.64752070
132	MP0001919_abnormal_reproductive_system	0.64532562
133	MP0004084_abnormal_cardiac_muscle	0.64167418
134	MP0000566_synostosis	0.64092075
135	MP0005084_abnormal_gallbladder_morpholo	0.63768105
136	MP0001501_abnormal_sleep_pattern	0.63521208
137	MP0005423_abnormal_somatic_nervous	0.62866358
138	MP0001963_abnormal_hearing_physiology	0.62636967

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.99627616
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.33969911
3	Mitochondrial inheritance (HP:0001427)	5.26614158
4	Progressive macrocephaly (HP:0004481)	4.96699600
5	Increased CSF lactate (HP:0002490)	4.67404800
6	Acute encephalopathy (HP:0006846)	4.56086482
7	Hepatocellular necrosis (HP:0001404)	4.42079304
8	Increased hepatocellular lipid droplets (HP:0006565)	4.39164280
9	Renal Fanconi syndrome (HP:0001994)	3.89129699
10	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.82748100
11	Lipid accumulation in hepatocytes (HP:0006561)	3.79598250
12	Hepatic necrosis (HP:0002605)	3.69552718
13	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.68771953
14	Abnormality of cells of the erythroid lineage (HP:0012130)	3.68688195
15	3-Methylglutaconic aciduria (HP:0003535)	3.63215344
16	Birth length less than 3rd percentile (HP:0003561)	3.63074921
17	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.57730442
18	Increased serum pyruvate (HP:0003542)	3.57248092
19	Abnormality of glycolysis (HP:0004366)	3.57248092
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.57154807
21	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.57154807
22	Exercise intolerance (HP:0003546)	3.46863257
23	Increased serum lactate (HP:0002151)	3.42547664
24	Abnormal number of erythroid precursors (HP:0012131)	3.25681612
25	Exertional dyspnea (HP:0002875)	3.24288586
26	Reticulocytopenia (HP:0001896)	3.14405959
27	Hypothermia (HP:0002045)	3.12273780
28	Respiratory failure (HP:0002878)	3.08956043
29	Lactic acidosis (HP:0003128)	3.03594200
30	Increased intramyocellular lipid droplets (HP:0012240)	2.99685565
31	Respiratory difficulties (HP:0002880)	2.97826431
32	Optic disc pallor (HP:0000543)	2.91602939
33	Cerebral edema (HP:0002181)	2.81233439
34	Rough bone trabeculation (HP:0100670)	2.80109511
35	Cerebral hypomyelination (HP:0006808)	2.79679662
36	Breast hypoplasia (HP:0003187)	2.78556940
37	Methylmalonic acidemia (HP:0002912)	2.73278081
38	Macrocytic anemia (HP:0001972)	2.70992468
39	Leukodystrophy (HP:0002415)	2.58567172
40	Type I transferrin isoform profile (HP:0003642)	2.51313167
41	Abnormality of urine glucose concentration (HP:0011016)	2.49163150
42	Glycosuria (HP:0003076)	2.49163150
43	Lethargy (HP:0001254)	2.43048907
44	Abnormality of midbrain morphology (HP:0002418)	2.42992975
45	Molar tooth sign on MRI (HP:0002419)	2.42992975
46	Microvesicular hepatic steatosis (HP:0001414)	2.41628419
47	Abnormal glycosylation (HP:0012345)	2.39752152
48	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.39752152
49	Abnormal protein N-linked glycosylation (HP:0012347)	2.39752152
50	Abnormal protein glycosylation (HP:0012346)	2.39752152
51	Increased muscle lipid content (HP:0009058)	2.34217595
52	Abnormality of renal resorption (HP:0011038)	2.31289146
53	True hermaphroditism (HP:0010459)	2.29322603
54	Carpal bone hypoplasia (HP:0001498)	2.28225909
55	Oral leukoplakia (HP:0002745)	2.26940932
56	Congenital ichthyosiform erythroderma (HP:0007431)	2.26748546
57	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.25767776
58	Methylmalonic aciduria (HP:0012120)	2.25601101
59	Cleft eyelid (HP:0000625)	2.25297593
60	Pallor (HP:0000980)	2.24192382
61	Emotional lability (HP:0000712)	2.20479261
62	CNS demyelination (HP:0007305)	2.16346117
63	Generalized aminoaciduria (HP:0002909)	2.16310912
64	Reduced antithrombin III activity (HP:0001976)	2.16041270
65	Aplastic anemia (HP:0001915)	2.15503239
66	Abnormal trabecular bone morphology (HP:0100671)	2.14379552
67	Nephronophthisis (HP:0000090)	2.12562049
68	Meckel diverticulum (HP:0002245)	2.11761147
69	Degeneration of anterior horn cells (HP:0002398)	2.11349866
70	Abnormality of the anterior horn cell (HP:0006802)	2.11349866
71	Poor head control (HP:0002421)	2.11117194
72	Abnormality of methionine metabolism (HP:0010901)	2.09006078
73	Abnormal pupillary function (HP:0007686)	2.06501575
74	Hyperphosphaturia (HP:0003109)	2.02422385
75	Delusions (HP:0000746)	1.98620490
76	Abnormality of the ileum (HP:0001549)	1.96694987
77	Unsteady gait (HP:0002317)	1.96187813
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.94645271
79	Hyperglycinemia (HP:0002154)	1.94242320
80	Agnosia (HP:0010524)	1.92758721
81	Patellar aplasia (HP:0006443)	1.92577897
82	Genital tract atresia (HP:0001827)	1.92509208
83	Irregular epiphyses (HP:0010582)	1.91689955
84	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.91271995
85	Microretrognathia (HP:0000308)	1.90737756
86	Increased IgM level (HP:0003496)	1.90384584
87	Vaginal atresia (HP:0000148)	1.89638015
88	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88901878
89	Medial flaring of the eyebrow (HP:0010747)	1.88051321
90	Abnormality of alanine metabolism (HP:0010916)	1.87594912
91	Hyperalaninemia (HP:0003348)	1.87594912
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87594912
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87189119
94	Premature graying of hair (HP:0002216)	1.86464981
95	Secondary amenorrhea (HP:0000869)	1.85357265
96	Septo-optic dysplasia (HP:0100842)	1.85240534
97	Multiple enchondromatosis (HP:0005701)	1.84773431
98	Abnormal ciliary motility (HP:0012262)	1.84217754
99	X-linked dominant inheritance (HP:0001423)	1.83004866
100	Type 2 muscle fiber atrophy (HP:0003554)	1.82727612
101	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.82270906
102	Colon cancer (HP:0003003)	1.82153497
103	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.82025685
104	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81967909
105	Absent radius (HP:0003974)	1.80565530
106	IgG deficiency (HP:0004315)	1.80263689
107	Postnatal microcephaly (HP:0005484)	1.79813668
108	CNS hypomyelination (HP:0003429)	1.79225982
109	Absent thumb (HP:0009777)	1.78198302
110	Abnormality of serum amino acid levels (HP:0003112)	1.77538682
111	Sclerocornea (HP:0000647)	1.77208891
112	Rhinitis (HP:0012384)	1.77079186
113	Elevated erythrocyte sedimentation rate (HP:0003565)	1.77026660
114	Trismus (HP:0000211)	1.76937475
115	Horseshoe kidney (HP:0000085)	1.76365268
116	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.74658311
117	Abnormality of the labia minora (HP:0012880)	1.74276928
118	Absent forearm bone (HP:0003953)	1.74271075
119	Aplasia involving forearm bones (HP:0009822)	1.74271075
120	Poor suck (HP:0002033)	1.73369335
121	Cellular immunodeficiency (HP:0005374)	1.70768175
122	Pancreatic fibrosis (HP:0100732)	1.70201654
123	Congenital, generalized hypertrichosis (HP:0004540)	1.69032309
124	Muscle fiber atrophy (HP:0100295)	1.68828665
125	Triphalangeal thumb (HP:0001199)	1.68570475
126	Abnormality of the preputium (HP:0100587)	1.68356265
127	Concave nail (HP:0001598)	1.67816034
128	Abnormality of vitamin B metabolism (HP:0004340)	1.67771655
129	Congenital primary aphakia (HP:0007707)	1.67011963
130	Hypoplasia of the pons (HP:0012110)	1.66602195
131	Amniotic constriction ring (HP:0009775)	1.66321443
132	Abnormality of placental membranes (HP:0011409)	1.66321443
133	Blindness (HP:0000618)	1.65101402
134	Abnormal hair whorl (HP:0010721)	1.64317619
135	Renal cortical cysts (HP:0000803)	1.63748315
136	Bifid tongue (HP:0010297)	1.63557890
137	Hyperinsulinemic hypoglycemia (HP:0000825)	1.63493044
138	Gait imbalance (HP:0002141)	1.63277495
139	Prolonged partial thromboplastin time (HP:0003645)	1.63071074
140	Pancreatic cysts (HP:0001737)	1.62886653
141	Nephrogenic diabetes insipidus (HP:0009806)	1.62677453
142	Abnormality of the pons (HP:0007361)	1.62025450
143	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.61069733
144	Sparse eyelashes (HP:0000653)	1.59962923

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BUB1	4.79959875
2	VRK2	4.66896359
3	STK16	3.31056821
4	NME2	3.28712053
5	WEE1	3.21292642
6	NUAK1	2.91762706
7	EIF2AK1	2.86854916
8	SRPK1	2.76025144
9	MAP3K12	2.60982090
10	NME1	2.53523762
11	CASK	2.50798389
12	EIF2AK3	2.48652295
13	ARAF	2.39291378
14	VRK1	2.23744849
15	TSSK6	2.06071579
16	PLK4	1.90897188
17	PNCK	1.83670059
18	PIM2	1.82459119
19	TRIM28	1.79627177
20	TESK2	1.73081286
21	MST4	1.71594150
22	FRK	1.61011969
23	BRAF	1.58543354
24	MAP4K2	1.54757823
25	PBK	1.53145985
26	INSRR	1.53066167
27	GRK1	1.52427168
28	BMPR2	1.48691311
29	CCNB1	1.44756228
30	PLK3	1.39969922
31	MKNK2	1.36710858
32	MKNK1	1.35394366
33	MYLK	1.34519546
34	CSNK1G1	1.33368344
35	TLK1	1.29636715
36	CDC7	1.29407693
37	SIK3	1.29094829
38	PLK2	1.19479815
39	RIPK4	1.14573216
40	PLK1	1.12583815
41	CSNK1G2	1.11963995
42	AURKA	1.10147809
43	BCR	1.08717328
44	CSNK1G3	1.08058460
45	TAF1	1.06844524
46	GRK7	1.06144142
47	TXK	1.04207103
48	DAPK1	1.01726505
49	NEK1	1.01694981
50	ADRBK2	1.01576693
51	BLK	0.99983516
52	CDK3	0.98593957
53	BRSK2	0.98312535
54	ACVR1B	0.97835371
55	CDK19	0.97622340
56	AKT3	0.96683119
57	EIF2AK2	0.92242536
58	MUSK	0.89595894
59	DYRK2	0.89145934
60	CDK8	0.87349114
61	CSNK1A1L	0.86444354
62	GRK5	0.85786275
63	MAP3K4	0.84931956
64	ZAK	0.84441473
65	MAP2K7	0.81768861
66	LIMK1	0.80750523
67	PHKG2	0.80465724
68	PHKG1	0.80465724
69	KDR	0.78749791
70	BMPR1B	0.74189861
71	PDK2	0.73806609
72	MAPKAPK5	0.72943808
73	BRSK1	0.72110308
74	STK39	0.71978570
75	AURKB	0.70728542
76	PAK3	0.70377414
77	ABL2	0.68690678
78	PDK3	0.67814315
79	PDK4	0.67814315
80	IRAK2	0.67322755
81	MAP3K11	0.66978224
82	CSNK2A1	0.65514707
83	TESK1	0.64983314
84	WNK3	0.63448462
85	DYRK3	0.62824643
86	EPHB2	0.60153247
87	NLK	0.57951538
88	CSNK2A2	0.57406829
89	IRAK4	0.56555567
90	ILK	0.56414517
91	TTK	0.56240436
92	IRAK3	0.55607916
93	TGFBR1	0.53980206
94	PRKCE	0.53708197
95	PRKCI	0.52068337
96	MAP2K6	0.51445746
97	MINK1	0.50455464
98	OBSCN	0.50400749
99	PASK	0.50195418
100	WNK4	0.50099973
101	RPS6KA5	0.49944396
102	PAK1	0.48154762
103	OXSR1	0.47287929
104	DAPK3	0.46508581
105	MAPK15	0.46474306
106	YES1	0.46432659
107	CSNK1A1	0.44928075
108	EPHA4	0.43410197
109	CAMK2B	0.43140936
110	TNIK	0.43054903
111	CDK18	0.43047332
112	RAF1	0.42780457
113	ATM	0.42135321
114	TAOK3	0.42100862
115	CDK14	0.41142927
116	NTRK3	0.40911122
117	BCKDK	0.40254861
118	PRKCG	0.38975461
119	MAPK13	0.37854694
120	NEK2	0.36588561
121	RPS6KA4	0.36473452
122	CDK7	0.36354650
123	CSNK1E	0.36192702
124	ATR	0.34794617
125	SYK	0.34703162
126	PAK4	0.34555122
127	STK24	0.34511314
128	ERBB3	0.34419936
129	CDK15	0.34277915
130	CDK11A	0.33895825
131	GRK6	0.33269189
132	CHEK2	0.32128945
133	CAMK2A	0.32040978
134	PINK1	0.28279035
135	ADRBK1	0.27239209

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	5.32718177
2	RNA polymerase_Homo sapiens_hsa03020	4.33184898
3	Ribosome_Homo sapiens_hsa03010	4.31379546
4	Oxidative phosphorylation_Homo sapiens_hsa00190	4.06911377
5	Parkinsons disease_Homo sapiens_hsa05012	3.38798516
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.98740758
7	DNA replication_Homo sapiens_hsa03030	2.93024956
8	Huntingtons disease_Homo sapiens_hsa05016	2.69368591
9	Mismatch repair_Homo sapiens_hsa03430	2.59662652
10	Pyrimidine metabolism_Homo sapiens_hsa00240	2.51586833
11	Spliceosome_Homo sapiens_hsa03040	2.42371913
12	Alzheimers disease_Homo sapiens_hsa05010	2.40825781
13	Protein export_Homo sapiens_hsa03060	2.33121011
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.17522166
15	Homologous recombination_Homo sapiens_hsa03440	1.99657464
16	RNA transport_Homo sapiens_hsa03013	1.98051517
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.88356253
18	Basal transcription factors_Homo sapiens_hsa03022	1.85964643
19	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.76723584
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.74220992
21	Base excision repair_Homo sapiens_hsa03410	1.70176904
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.63472985
23	Purine metabolism_Homo sapiens_hsa00230	1.57311077
24	Propanoate metabolism_Homo sapiens_hsa00640	1.47289822
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.37783788
26	RNA degradation_Homo sapiens_hsa03018	1.36928728
27	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.35784719
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30740796
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.29369338
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.22404644
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21146810
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.19689178
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.18817808
34	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.16428370
35	Cell cycle_Homo sapiens_hsa04110	1.11765346
36	Butanoate metabolism_Homo sapiens_hsa00650	1.09280659
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03803992
38	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.02938609
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.02762712
40	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.00911360
41	Vibrio cholerae infection_Homo sapiens_hsa05110	1.00885571
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.00572764
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.00169266
44	Peroxisome_Homo sapiens_hsa04146	0.97237189
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.96962262
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96057462
47	Nicotine addiction_Homo sapiens_hsa05033	0.95867863
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.92603418
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.91394278
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.90117791
51	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.89319476
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87247323
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.86224852
54	Sulfur metabolism_Homo sapiens_hsa00920	0.84413982
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81769455
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80963070
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.79747618
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79483487
59	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79351523
60	Allograft rejection_Homo sapiens_hsa05330	0.79236274
61	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76697196
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.73764930
63	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.72383282
64	One carbon pool by folate_Homo sapiens_hsa00670	0.71096835
65	Caffeine metabolism_Homo sapiens_hsa00232	0.70346739
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.69122829
67	Regulation of autophagy_Homo sapiens_hsa04140	0.68249689
68	Retinol metabolism_Homo sapiens_hsa00830	0.61883132
69	Oocyte meiosis_Homo sapiens_hsa04114	0.59083151
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58307610
71	Phagosome_Homo sapiens_hsa04145	0.57942544
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.55757593
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.55650684
74	Metabolic pathways_Homo sapiens_hsa01100	0.54960819
75	Fatty acid degradation_Homo sapiens_hsa00071	0.53874409
76	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.53677233
77	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.51911062
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51853131
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51696329
80	p53 signaling pathway_Homo sapiens_hsa04115	0.51620378
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51071628
82	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.50038441
83	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.47141587
84	Asthma_Homo sapiens_hsa05310	0.46807361
85	Glutathione metabolism_Homo sapiens_hsa00480	0.45284057
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.44386114
87	Antigen processing and presentation_Homo sapiens_hsa04612	0.42968951
88	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.42307133
89	Legionellosis_Homo sapiens_hsa05134	0.40796914
90	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40169156
91	Folate biosynthesis_Homo sapiens_hsa00790	0.38371058
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37762768
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.37087130
94	Mineral absorption_Homo sapiens_hsa04978	0.36834459
95	Linoleic acid metabolism_Homo sapiens_hsa00591	0.35114003
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.33139604
97	Serotonergic synapse_Homo sapiens_hsa04726	0.32465052
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31696299
99	Primary immunodeficiency_Homo sapiens_hsa05340	0.31632356
100	Phototransduction_Homo sapiens_hsa04744	0.31402939
101	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.30417817
102	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30033811
103	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29632074
104	Histidine metabolism_Homo sapiens_hsa00340	0.27283178
105	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25378199
106	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24471709
107	Fatty acid metabolism_Homo sapiens_hsa01212	0.23875377
108	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23632252
109	Carbon metabolism_Homo sapiens_hsa01200	0.22448597
110	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.20799045
111	Pentose phosphate pathway_Homo sapiens_hsa00030	0.19727183
112	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.19434872
113	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.19413197
114	Herpes simplex infection_Homo sapiens_hsa05168	0.18672403
115	Alcoholism_Homo sapiens_hsa05034	0.18421564
116	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.18084825
117	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.17395073
118	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.17254396
119	Amphetamine addiction_Homo sapiens_hsa05031	0.16619172
120	Basal cell carcinoma_Homo sapiens_hsa05217	0.16073883
121	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.15606745
122	Arginine and proline metabolism_Homo sapiens_hsa00330	0.14583573
123	Olfactory transduction_Homo sapiens_hsa04740	0.13780257
124	African trypanosomiasis_Homo sapiens_hsa05143	0.13097352
125	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.12803833
126	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.11518545
127	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.11067739
128	Shigellosis_Homo sapiens_hsa05131	0.09547237
129	Sphingolipid metabolism_Homo sapiens_hsa00600	0.09113395
130	Ether lipid metabolism_Homo sapiens_hsa00565	0.08891548
131	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.08461775
132	Taste transduction_Homo sapiens_hsa04742	0.08032210
133	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.07585316
134	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.07501874
135	Phenylalanine metabolism_Homo sapiens_hsa00360	0.06168482
136	Calcium signaling pathway_Homo sapiens_hsa04020	0.06156170
137	Fatty acid elongation_Homo sapiens_hsa00062	0.06043097
138	Sulfur relay system_Homo sapiens_hsa04122	0.05408705
139	Viral carcinogenesis_Homo sapiens_hsa05203	0.04716351
140	Morphine addiction_Homo sapiens_hsa05032	0.04686369
141	Pertussis_Homo sapiens_hsa05133	0.04028142
142	GABAergic synapse_Homo sapiens_hsa04727	0.03998354

EEF1AKMT1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »