EEF1B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.52860071
2viral transcription (GO:0019083)7.46769056
3translational termination (GO:0006415)7.27251056
4ribosomal small subunit biogenesis (GO:0042274)6.61137028
5* translational elongation (GO:0006414)6.29980346
6maturation of SSU-rRNA (GO:0030490)6.25904539
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.13005423
8protein targeting to ER (GO:0045047)5.99564120
9cotranslational protein targeting to membrane (GO:0006613)5.99211591
10nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.88559389
11translational initiation (GO:0006413)5.75578605
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.72924048
13ribosomal large subunit biogenesis (GO:0042273)5.68830414
14cellular protein complex disassembly (GO:0043624)5.65054667
15viral life cycle (GO:0019058)5.63092634
16protein localization to endoplasmic reticulum (GO:0070972)5.59201716
17protein complex disassembly (GO:0043241)5.02271178
18formation of translation preinitiation complex (GO:0001731)4.79334160
19macromolecular complex disassembly (GO:0032984)4.72038896
20ribonucleoprotein complex biogenesis (GO:0022613)4.57868366
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51231000
22DNA unwinding involved in DNA replication (GO:0006268)4.39461183
23nuclear-transcribed mRNA catabolic process (GO:0000956)4.34576666
24DNA strand elongation involved in DNA replication (GO:0006271)4.18399234
25energy coupled proton transport, down electrochemical gradient (GO:0015985)4.14224906
26ATP synthesis coupled proton transport (GO:0015986)4.14224906
27mRNA catabolic process (GO:0006402)4.11700864
28* translation (GO:0006412)4.08566496
29protein targeting to membrane (GO:0006612)3.96214407
30DNA strand elongation (GO:0022616)3.95255894
31DNA replication initiation (GO:0006270)3.94996995
32RNA catabolic process (GO:0006401)3.94359664
33nucleotide salvage (GO:0043173)3.88204489
34telomere maintenance via semi-conservative replication (GO:0032201)3.85132521
35folic acid-containing compound biosynthetic process (GO:0009396)3.78395325
36rRNA processing (GO:0006364)3.75835663
37pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.72899827
38rRNA metabolic process (GO:0016072)3.62911354
39pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.61205519
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.59612104
41pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.59290363
42nucleoside salvage (GO:0043174)3.57963284
43IMP biosynthetic process (GO:0006188)3.56051544
44CTP metabolic process (GO:0046036)3.56027268
45CTP biosynthetic process (GO:0006241)3.56027268
46pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.55606705
47protein targeting (GO:0006605)3.50180114
48protein localization to kinetochore (GO:0034501)3.48241187
49ribosome assembly (GO:0042255)3.47885464
50ribosome biogenesis (GO:0042254)3.44687432
51nucleobase biosynthetic process (GO:0046112)3.44686657
52pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.42563382
53telomere maintenance via recombination (GO:0000722)3.39816472
54DNA deamination (GO:0045006)3.39464266
55chromatin remodeling at centromere (GO:0031055)3.29656054
56cellular component biogenesis (GO:0044085)3.29648915
57mitotic recombination (GO:0006312)3.29087591
58DNA ligation (GO:0006266)3.27569581
59CENP-A containing nucleosome assembly (GO:0034080)3.26998973
60DNA replication checkpoint (GO:0000076)3.26285420
61mitotic nuclear envelope disassembly (GO:0007077)3.25637330
62IMP metabolic process (GO:0046040)3.25627919
63pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.25009376
64UMP biosynthetic process (GO:0006222)3.25009376
65pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.25009376
66UMP metabolic process (GO:0046049)3.25009376
67oxidative phosphorylation (GO:0006119)3.23506840
68nuclear pore organization (GO:0006999)3.22315043
69DNA replication-dependent nucleosome organization (GO:0034723)3.20955164
70DNA replication-dependent nucleosome assembly (GO:0006335)3.20955164
71telomere maintenance via telomere lengthening (GO:0010833)3.19197939
72spliceosomal snRNP assembly (GO:0000387)3.14840270
73mitotic metaphase plate congression (GO:0007080)3.13851256
74RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07935611
75tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07935611
76purine nucleobase biosynthetic process (GO:0009113)3.07015350
77DNA replication-independent nucleosome assembly (GO:0006336)3.05255547
78DNA replication-independent nucleosome organization (GO:0034724)3.05255547
79ncRNA 3-end processing (GO:0043628)3.04325719
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.02772038
81nuclear pore complex assembly (GO:0051292)3.02620206
82protein localization to chromosome, centromeric region (GO:0071459)3.01931072
83nuclear envelope disassembly (GO:0051081)3.01480801
84membrane disassembly (GO:0030397)3.01480801
85kinetochore organization (GO:0051383)3.01237992
86pyrimidine-containing compound salvage (GO:0008655)2.98675583
87pyrimidine nucleoside salvage (GO:0043097)2.98675583
88negative regulation of RNA splicing (GO:0033119)2.98391554
89protein localization to membrane (GO:0072657)2.94586699
90establishment of integrated proviral latency (GO:0075713)2.93418078
91pseudouridine synthesis (GO:0001522)2.92297148
92establishment of protein localization to mitochondrial membrane (GO:0090151)2.91711405
93spliceosomal complex assembly (GO:0000245)2.90801390
94chaperone-mediated protein transport (GO:0072321)2.89519812
95purine nucleotide salvage (GO:0032261)2.88567391
96regulation of gene silencing by RNA (GO:0060966)2.87716102
97regulation of posttranscriptional gene silencing (GO:0060147)2.87716102
98regulation of gene silencing by miRNA (GO:0060964)2.87716102
99regulation of spindle organization (GO:0090224)2.84401503
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81105916
101metaphase plate congression (GO:0051310)2.80765926
102respiratory electron transport chain (GO:0022904)2.80575215
103DNA duplex unwinding (GO:0032508)2.78479922
104pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76961203
105DNA geometric change (GO:0032392)2.76587637
106pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.75794881
107pentose metabolic process (GO:0019321)2.73923266
108pyrimidine nucleotide biosynthetic process (GO:0006221)2.72556492
109RNA splicing, via transesterification reactions (GO:0000375)2.72458535
110regulation of translational fidelity (GO:0006450)2.72365841
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71230584
112mRNA splicing, via spliceosome (GO:0000398)2.71230584
113regulation of mitochondrial translation (GO:0070129)2.71152916
114negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.70695121
115electron transport chain (GO:0022900)2.70431304
116ncRNA processing (GO:0034470)2.69673296
117mitochondrial respiratory chain complex assembly (GO:0033108)2.68313094
118termination of RNA polymerase III transcription (GO:0006386)2.66644889
119transcription elongation from RNA polymerase III promoter (GO:0006385)2.66644889
120establishment of protein localization to membrane (GO:0090150)2.65858163
121viral mRNA export from host cell nucleus (GO:0046784)2.65516993
122kinetochore assembly (GO:0051382)2.64768948
123negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.64683668
124histone exchange (GO:0043486)2.63684181
125transcription-coupled nucleotide-excision repair (GO:0006283)2.63044503
126ribonucleoprotein complex assembly (GO:0022618)2.61877979
127protein targeting to mitochondrion (GO:0006626)2.60659231
128establishment of protein localization to organelle (GO:0072594)2.60398913
129protein complex biogenesis (GO:0070271)2.60279760
130ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60121256
131somatic hypermutation of immunoglobulin genes (GO:0016446)2.60031830
132somatic diversification of immune receptors via somatic mutation (GO:0002566)2.60031830
133nucleobase-containing small molecule interconversion (GO:0015949)2.59844116
134mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59266224
135mitochondrial respiratory chain complex I assembly (GO:0032981)2.59266224
136NADH dehydrogenase complex assembly (GO:0010257)2.59266224
137* gene expression (GO:0010467)2.57121275
138ncRNA metabolic process (GO:0034660)2.56831269
139pteridine-containing compound biosynthetic process (GO:0042559)2.56331809
140regulation of mitotic spindle organization (GO:0060236)2.56320082
141pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.56283391
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56223703
143attachment of spindle microtubules to kinetochore (GO:0008608)2.55774396
144regulation of helicase activity (GO:0051095)2.55650436
145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55148717
146mitotic sister chromatid segregation (GO:0000070)2.54472656
147G1/S transition of mitotic cell cycle (GO:0000082)2.54242543
148cell cycle G1/S phase transition (GO:0044843)2.54242543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83185357
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.82025197
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89304572
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.46149025
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.38755955
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30280173
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89482936
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87494348
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.86357271
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84602876
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.74832713
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.72858183
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70583416
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69271011
15XRN2_22483619_ChIP-Seq_HELA_Human2.56726511
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44940604
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39933748
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34040620
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33900256
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32758106
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.26047301
22* VDR_23849224_ChIP-Seq_CD4+_Human2.16488465
23TTF2_22483619_ChIP-Seq_HELA_Human2.08299571
24DCP1A_22483619_ChIP-Seq_HELA_Human2.03810309
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01219415
26AR_21909140_ChIP-Seq_LNCAP_Human1.95995656
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92358380
28FOXP3_21729870_ChIP-Seq_TREG_Human1.91203567
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85337113
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.81303379
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81283244
32MYC_22102868_ChIP-Seq_BL_Human1.80987683
33* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80644881
34* ELK1_19687146_ChIP-ChIP_HELA_Human1.74219492
35GABP_19822575_ChIP-Seq_HepG2_Human1.69037130
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68638134
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66707440
38* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63202398
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61580370
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61057711
41* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58750627
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58141437
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56090703
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.55973883
45* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50789779
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50084254
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48296887
48* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43086207
49CIITA_25753668_ChIP-Seq_RAJI_Human1.42887634
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41472815
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41362861
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41126339
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40854761
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40272831
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30772727
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29950686
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.29045893
58* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28263850
59* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27263504
60* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25935687
61* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25026679
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.24926482
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22674852
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21831950
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.21466647
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21416981
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21113536
68* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19983904
69* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19886296
70VDR_21846776_ChIP-Seq_THP-1_Human1.16963982
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15780332
72SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15678981
73TFEB_21752829_ChIP-Seq_HELA_Human1.15564636
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13933116
75TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13440665
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10481483
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09038491
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.08113788
79* ELK1_22589737_ChIP-Seq_MCF10A_Human1.07883901
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.07528922
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07353412
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05239266
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05239266
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05239266
85MYC_18940864_ChIP-ChIP_HL60_Human1.04783672
86* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04725450
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03781986
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01012162
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99754682
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99703324
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99549217
92SPI1_23547873_ChIP-Seq_NB4_Human0.97040813
93PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96462614
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96279216
95* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95640786
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94585691
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93308145
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91954329
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91514883
100* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90513824
101SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90409156
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89390084
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89188302
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87834148
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84926716
106* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82511246
107PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.82119077
108ZNF263_19887448_ChIP-Seq_K562_Human0.79189272
109MYB_26560356_Chip-Seq_TH2_Human0.76486520
110CTCF_18555785_ChIP-Seq_MESCs_Mouse0.74369003
111MYB_26560356_Chip-Seq_TH1_Human0.71689191
112UTX_26944678_Chip-Seq_JUKART_Human0.68965063
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68429415
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68401434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57744728
2MP0004957_abnormal_blastocyst_morpholog4.14055774
3MP0010094_abnormal_chromosome_stability3.68304232
4MP0003111_abnormal_nucleus_morphology3.41625288
5MP0003077_abnormal_cell_cycle3.33234655
6MP0009379_abnormal_foot_pigmentation3.01122438
7MP0008057_abnormal_DNA_replication2.63624087
8MP0008058_abnormal_DNA_repair2.61014756
9MP0006292_abnormal_olfactory_placode2.50427446
10MP0008007_abnormal_cellular_replicative2.48819437
11MP0010352_gastrointestinal_tract_polyps2.45128246
12MP0008932_abnormal_embryonic_tissue2.34187588
13MP0002396_abnormal_hematopoietic_system2.28620566
14MP0003123_paternal_imprinting2.26595623
15MP0002163_abnormal_gland_morphology2.11515612
16MP0001730_embryonic_growth_arrest2.05222228
17MP0000350_abnormal_cell_proliferation2.03114293
18MP0000490_abnormal_crypts_of1.92831096
19MP0001835_abnormal_antigen_presentation1.89507567
20MP0004808_abnormal_hematopoietic_stem1.75230082
21MP0003941_abnormal_skin_development1.68932949
22MP0003567_abnormal_fetal_cardiomyocyte1.62736621
23MP0010030_abnormal_orbit_morphology1.62148173
24MP0003786_premature_aging1.58160569
25MP0006036_abnormal_mitochondrial_physio1.57343644
26MP0001697_abnormal_embryo_size1.55109370
27MP0001873_stomach_inflammation1.52009922
28MP0010307_abnormal_tumor_latency1.48552237
29MP0005380_embryogenesis_phenotype1.47758635
30MP0001672_abnormal_embryogenesis/_devel1.47758635
31MP0000537_abnormal_urethra_morphology1.45686828
32MP0004197_abnormal_fetal_growth/weight/1.43960750
33MP0002080_prenatal_lethality1.43677939
34MP0006054_spinal_hemorrhage1.43658281
35MP0005075_abnormal_melanosome_morpholog1.38553058
36MP0002085_abnormal_embryonic_tissue1.38157281
37MP0002084_abnormal_developmental_patter1.37457119
38MP0005360_urolithiasis1.35054892
39MP0009697_abnormal_copulation1.34990808
40MP0003984_embryonic_growth_retardation1.34773829
41MP0009333_abnormal_splenocyte_physiolog1.34726889
42MP0002088_abnormal_embryonic_growth/wei1.33472701
43MP0002086_abnormal_extraembryonic_tissu1.33182663
44MP0008995_early_reproductive_senescence1.32943960
45MP0006035_abnormal_mitochondrial_morpho1.32803123
46MP0002019_abnormal_tumor_incidence1.31810856
47MP0003763_abnormal_thymus_physiology1.28913952
48MP0000313_abnormal_cell_death1.27877921
49MP0002160_abnormal_reproductive_system1.26902292
50MP0009053_abnormal_anal_canal1.25165828
51MP0003705_abnormal_hypodermis_morpholog1.22498256
52MP0005408_hypopigmentation1.22471227
53MP0000372_irregular_coat_pigmentation1.22359860
54MP0005076_abnormal_cell_differentiation1.21040474
55MP0005023_abnormal_wound_healing1.20975558
56MP0001293_anophthalmia1.18134424
57MP0004147_increased_porphyrin_level1.14498066
58MP0000703_abnormal_thymus_morphology1.13972909
59MP0005397_hematopoietic_system_phenotyp1.10674144
60MP0001545_abnormal_hematopoietic_system1.10674144
61MP0000858_altered_metastatic_potential1.09126287
62MP0003566_abnormal_cell_adhesion1.09000867
63MP0003806_abnormal_nucleotide_metabolis1.06830286
64MP0002398_abnormal_bone_marrow1.04435738
65MP0005501_abnormal_skin_physiology1.02371499
66MP0002722_abnormal_immune_system1.02369605
67MP0003315_abnormal_perineum_morphology1.00140329
68MP0010234_abnormal_vibrissa_follicle0.99129391
69MP0005379_endocrine/exocrine_gland_phen0.99079282
70MP0001881_abnormal_mammary_gland0.97441429
71MP0002111_abnormal_tail_morphology0.96082241
72MP0002132_abnormal_respiratory_system0.95436435
73MP0005671_abnormal_response_to0.91957539
74MP0000689_abnormal_spleen_morphology0.91876438
75MP0004133_heterotaxia0.91048446
76MP0005389_reproductive_system_phenotype0.89641382
77MP0008438_abnormal_cutaneous_collagen0.89483811
78MP0003121_genomic_imprinting0.88784301
79MP0003119_abnormal_digestive_system0.88214133
80MP0003718_maternal_effect0.87955904
81MP0002009_preneoplasia0.86884717
82MP0000477_abnormal_intestine_morphology0.86092162
83MP0001764_abnormal_homeostasis0.85597381
84MP0004264_abnormal_extraembryonic_tissu0.84995365
85MP0001819_abnormal_immune_cell0.83840124
86MP0004185_abnormal_adipocyte_glucose0.83706466
87MP0002429_abnormal_blood_cell0.83137891
88MP0002420_abnormal_adaptive_immunity0.82632674
89MP0002452_abnormal_antigen_presenting0.82317918
90MP0003186_abnormal_redox_activity0.80382511
91MP0001929_abnormal_gametogenesis0.79185593
92MP0000358_abnormal_cell_content/0.78944683
93MP0005000_abnormal_immune_tolerance0.75812861
94MP0002938_white_spotting0.75001075
95MP0002060_abnormal_skin_morphology0.74744108
96MP0001348_abnormal_lacrimal_gland0.73799001
97MP0005464_abnormal_platelet_physiology0.73740772
98MP0008877_abnormal_DNA_methylation0.73192820
99MP0002723_abnormal_immune_serum0.71867741
100MP0002282_abnormal_trachea_morphology0.71811351
101MP0002877_abnormal_melanocyte_morpholog0.71263951
102MP0002796_impaired_skin_barrier0.71227728
103MP0000465_gastrointestinal_hemorrhage0.71139813
104MP0000653_abnormal_sex_gland0.71133279
105MP0001915_intracranial_hemorrhage0.71098926
106MP0002210_abnormal_sex_determination0.69774794
107MP0000716_abnormal_immune_system0.69196881
108MP0010155_abnormal_intestine_physiology0.68751348
109MP0001286_abnormal_eye_development0.68391914
110MP0005367_renal/urinary_system_phenotyp0.68241074
111MP0000516_abnormal_urinary_system0.68241074
112MP0001853_heart_inflammation0.68035507
113MP0002166_altered_tumor_susceptibility0.67806808
114MP0002095_abnormal_skin_pigmentation0.67253487
115MP0001849_ear_inflammation0.66850325
116MP0005275_abnormal_skin_tensile0.66523479
117MP0001529_abnormal_vocalization0.66218169
118MP0005174_abnormal_tail_pigmentation0.65940818
119MP0001119_abnormal_female_reproductive0.65781803
120MP0002092_abnormal_eye_morphology0.65646368
121MP0001145_abnormal_male_reproductive0.65580008
122MP0003448_altered_tumor_morphology0.65495583
123MP0000733_abnormal_muscle_development0.65178998
124MP0000750_abnormal_muscle_regeneration0.65116320
125MP0003937_abnormal_limbs/digits/tail_de0.64390442
126MP0009278_abnormal_bone_marrow0.64033201
127MP0000685_abnormal_immune_system0.63896369
128MP0009672_abnormal_birth_weight0.63855374
129MP0000049_abnormal_middle_ear0.63841803
130MP0003453_abnormal_keratinocyte_physiol0.63709673
131MP0001243_abnormal_dermal_layer0.63684274
132MP0001800_abnormal_humoral_immune0.63533111
133MP0001216_abnormal_epidermal_layer0.63351399
134MP0002006_tumorigenesis0.63146836
135MP0005384_cellular_phenotype0.61968638
136MP0001666_abnormal_nutrient_absorption0.60665802

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.97305205
2Reticulocytopenia (HP:0001896)6.83069826
3Abnormal number of erythroid precursors (HP:0012131)6.28332278
4Macrocytic anemia (HP:0001972)4.89995650
5Pallor (HP:0000980)4.59923995
6Increased hepatocellular lipid droplets (HP:0006565)4.31019326
7Acute necrotizing encephalopathy (HP:0006965)4.20916712
8Colon cancer (HP:0003003)4.12378043
9Abnormal mitochondria in muscle tissue (HP:0008316)3.94203410
10Lipid accumulation in hepatocytes (HP:0006561)3.80037481
11Mitochondrial inheritance (HP:0001427)3.77825807
12Acute encephalopathy (HP:0006846)3.76802788
13Hepatocellular necrosis (HP:0001404)3.67807385
14Increased CSF lactate (HP:0002490)3.52853274
15Microvesicular hepatic steatosis (HP:0001414)3.48157730
16Thrombocytosis (HP:0001894)3.40178274
17Birth length less than 3rd percentile (HP:0003561)3.39934994
18Progressive macrocephaly (HP:0004481)3.28922556
19Increased intramyocellular lipid droplets (HP:0012240)3.27776902
20Respiratory difficulties (HP:0002880)3.23558477
21Hepatic necrosis (HP:0002605)3.22026350
22Aplastic anemia (HP:0001915)3.16459330
23Oral leukoplakia (HP:0002745)3.11917420
24Cerebral edema (HP:0002181)3.10929481
25Trismus (HP:0000211)3.10091133
26Selective tooth agenesis (HP:0001592)3.05969245
27Breast hypoplasia (HP:0003187)3.01940716
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.97658024
29Abnormal hemoglobin (HP:0011902)2.92214101
3011 pairs of ribs (HP:0000878)2.91796612
31Absent thumb (HP:0009777)2.90864675
32Abnormality of the anterior horn cell (HP:0006802)2.86327021
33Degeneration of anterior horn cells (HP:0002398)2.86327021
34Renal Fanconi syndrome (HP:0001994)2.85588522
35Multiple enchondromatosis (HP:0005701)2.75804141
36Increased muscle lipid content (HP:0009058)2.68141660
37Increased serum lactate (HP:0002151)2.65695398
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62209487
39Ependymoma (HP:0002888)2.51106371
40Exertional dyspnea (HP:0002875)2.50965307
41Lactic acidosis (HP:0003128)2.49763946
42Rough bone trabeculation (HP:0100670)2.44401351
43Stenosis of the external auditory canal (HP:0000402)2.42265771
44Abnormality of reticulocytes (HP:0004312)2.41467213
45Microretrognathia (HP:0000308)2.40314906
46Neoplasm of the pancreas (HP:0002894)2.40299536
47Basal cell carcinoma (HP:0002671)2.39718766
48Exercise intolerance (HP:0003546)2.39297620
49Missing ribs (HP:0000921)2.38662950
50Medulloblastoma (HP:0002885)2.37996933
51Glossoptosis (HP:0000162)2.32429195
52Atresia of the external auditory canal (HP:0000413)2.29271995
53Asplenia (HP:0001746)2.29253268
54Rhabdomyosarcoma (HP:0002859)2.27724242
55Carpal bone hypoplasia (HP:0001498)2.26587230
56Myelodysplasia (HP:0002863)2.25864496
57Patellar aplasia (HP:0006443)2.25474868
58Agnosia (HP:0010524)2.25297195
59Hypoplasia of the pons (HP:0012110)2.25221941
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24927341
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19104451
62Panhypogammaglobulinemia (HP:0003139)2.18873334
63Chromsome breakage (HP:0040012)2.17374808
64Depressed nasal ridge (HP:0000457)2.16789329
65Protrusio acetabuli (HP:0003179)2.16719199
66Aplasia/Hypoplasia of the patella (HP:0006498)2.14737319
67Leukodystrophy (HP:0002415)2.14669982
68Triphalangeal thumb (HP:0001199)2.14527677
69Proximal placement of thumb (HP:0009623)2.14002961
70Increased serum pyruvate (HP:0003542)2.12516566
71Abnormal number of incisors (HP:0011064)2.12358620
72Reduced antithrombin III activity (HP:0001976)2.12217565
73Respiratory failure (HP:0002878)2.11881173
74Aplasia/Hypoplasia of the spleen (HP:0010451)2.10070094
75Deviation of the thumb (HP:0009603)2.09634698
76Amaurosis fugax (HP:0100576)2.08086077
77Abnormality of the preputium (HP:0100587)2.06770621
78Biliary tract neoplasm (HP:0100574)2.06089154
79Abnormality of the pons (HP:0007361)2.04623204
80Agammaglobulinemia (HP:0004432)2.02326935
81Premature graying of hair (HP:0002216)2.01894068
82Abnormality of chromosome stability (HP:0003220)2.00098124
83Squamous cell carcinoma (HP:0002860)1.99728780
843-Methylglutaconic aciduria (HP:0003535)1.98275634
85Sensory axonal neuropathy (HP:0003390)1.97002697
86Abnormality of glycolysis (HP:0004366)1.96981215
87Neoplasm of the colon (HP:0100273)1.96175402
88Absent radius (HP:0003974)1.95837581
89Meckel diverticulum (HP:0002245)1.95458707
90Hypoplasia of the radius (HP:0002984)1.94461703
91Acute lymphatic leukemia (HP:0006721)1.93707095
92Horseshoe kidney (HP:0000085)1.92956942
93Congenital, generalized hypertrichosis (HP:0004540)1.91817803
94Cleft eyelid (HP:0000625)1.91779343
95Thick lower lip vermilion (HP:0000179)1.91684929
96Abnormality of DNA repair (HP:0003254)1.87548339
97Supernumerary spleens (HP:0009799)1.87530922
98Abnormality of the calcaneus (HP:0008364)1.84198548
99Type I transferrin isoform profile (HP:0003642)1.82823028
100Sparse lateral eyebrow (HP:0005338)1.82180883
101Short middle phalanx of the 5th finger (HP:0004220)1.82071721
102Irregular epiphyses (HP:0010582)1.81300340
103Abnormality of the ileum (HP:0001549)1.80595005
104Absent forearm bone (HP:0003953)1.77686426
105Aplasia involving forearm bones (HP:0009822)1.77686426
106Adenoma sebaceum (HP:0009720)1.77584246
107Angiofibromas (HP:0010615)1.77584246
108Tracheoesophageal fistula (HP:0002575)1.77122868
109Optic disc pallor (HP:0000543)1.76870959
110Progressive external ophthalmoplegia (HP:0000590)1.76774517
111Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75184114
112Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75184114
113CNS demyelination (HP:0007305)1.74694675
114Slender long bone (HP:0003100)1.73692003
115B lymphocytopenia (HP:0010976)1.73636394
116Abnormality of methionine metabolism (HP:0010901)1.73555622
117Abdominal situs inversus (HP:0003363)1.72600142
118Abnormality of abdominal situs (HP:0011620)1.72600142
119Calcaneovalgus deformity (HP:0001848)1.72338768
120IgM deficiency (HP:0002850)1.72090803
121Lymphoma (HP:0002665)1.71204438
122Abnormal trabecular bone morphology (HP:0100671)1.70695032
123Neoplasm of the rectum (HP:0100743)1.70515752
124Amniotic constriction ring (HP:0009775)1.69653357
125Abnormality of placental membranes (HP:0011409)1.69653357
126Hyperglycinemia (HP:0002154)1.68690141
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.67664459
128Megaloblastic anemia (HP:0001889)1.67538759
129Poikiloderma (HP:0001029)1.66797702
130Lethargy (HP:0001254)1.66505566
131Cellular immunodeficiency (HP:0005374)1.66109826
132Aplasia/Hypoplasia of the thymus (HP:0010515)1.66066867
133Small intestinal stenosis (HP:0012848)1.65428120
134Duodenal stenosis (HP:0100867)1.65428120
135Overlapping toe (HP:0001845)1.65143645
136Migraine (HP:0002076)1.65076876
137Abnormality of the phalanges of the 5th finger (HP:0004213)1.64887712
138Abnormality of renal resorption (HP:0011038)1.64646014
139Rectal prolapse (HP:0002035)1.63121555
140Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.62798068
141Achilles tendon contracture (HP:0001771)1.62797122
142Sparse eyelashes (HP:0000653)1.61582493
143Hyperphosphaturia (HP:0003109)1.61105862
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60330399
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.59922326
146Progressive muscle weakness (HP:0003323)1.59866447
147Pancytopenia (HP:0001876)1.59354284
148Abnormal lung lobation (HP:0002101)1.59177859
149Bone marrow hypocellularity (HP:0005528)1.56095710
150Woolly hair (HP:0002224)1.55376777
151Premature ovarian failure (HP:0008209)1.55047781
152Deformed tarsal bones (HP:0008119)1.54710401
153Short thumb (HP:0009778)1.52929259
154Increased density of long bones (HP:0006392)1.52002388
155Preauricular skin tag (HP:0000384)1.51425117
156Facial cleft (HP:0002006)1.50509262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.35254854
2WEE13.75426809
3BUB13.53368994
4CDC73.34067936
5VRK23.28054359
6EIF2AK12.85173083
7NEK22.43679469
8RPS6KB22.39397734
9EEF2K2.29582003
10PASK2.24007289
11SRPK12.17772388
12TSSK62.11880894
13TLK12.06839868
14TGFBR12.02689611
15MKNK11.98653312
16NEK11.91927220
17RPS6KA41.87702296
18DYRK31.85658143
19ACVR1B1.76440552
20PKN21.72523578
21TTK1.65362772
22AURKB1.63450355
23LRRK21.61879832
24EIF2AK31.61148114
25BRSK21.60334914
26TAF11.59630048
27CDK71.58770100
28PLK11.54925034
29MAP3K131.53781706
30TESK21.53341836
31SMG11.51369090
32PIM21.44822416
33EPHA21.44743785
34FLT31.44324771
35VRK11.44208671
36SCYL21.43720437
37STK161.40008609
38PAK41.31461552
39ATR1.28394752
40MAP3K81.28088033
41STK101.25620970
42MAP3K121.23390393
43MKNK21.20686377
44NUAK11.18395495
45CDK41.16031713
46PLK41.15889521
47BMPR21.14347641
48MST41.13849759
49MAP3K101.12035863
50PLK31.10416066
51AURKA1.09680827
52MAP4K11.06945316
53PIM11.04922602
54CHEK20.97877213
55CDK120.91640680
56CHEK10.91521013
57MAP2K30.91179709
58CDK60.88972986
59MAPKAPK30.88047782
60STK40.83070093
61ALK0.79905821
62TEC0.79445486
63* CSNK2A20.77881731
64MAP3K140.77403560
65DAPK30.75104860
66ILK0.74722206
67PRPF4B0.72029409
68PDK20.71781925
69TESK10.68385615
70ZAP700.67204851
71ATM0.66585027
72CDK80.65641815
73BTK0.65610549
74EIF2AK20.64108751
75CDK20.63936579
76* CSNK2A10.63774498
77STK240.63710132
78PAK20.63079904
79KDR0.61142957
80PAK10.59606835
81RPS6KA50.59365937
82MAP3K30.59192592
83DAPK10.58507614
84CDK190.57353167
85CCNB10.54957411
86BRSK10.53433717
87MAP3K110.53276199
88NME10.53183294
89BRD40.52307480
90NEK90.52123972
91PIK3CG0.50411738
92ABL20.50139574
93PRKCI0.49160029
94ITK0.44205720
95NLK0.43888351
96JAK30.43775555
97MELK0.43540699
98GRK60.42338732
99TRIB30.41602382
100PBK0.41423736
101LYN0.41185480
102RPS6KB10.38274180
103IRAK30.38088675
104CDK10.37047746
105PIK3CA0.36590117
106BRAF0.35934256
107LIMK10.35074827
108TXK0.34694889
109ZAK0.33884161
110KIT0.33537175
111MAP2K20.33260732
112AKT20.32907307
113MAPKAPK50.32257828
114CSF1R0.31550151
115SYK0.30890843
116CDK90.30832631
117STK30.30693743
118IKBKB0.30499612
119MAPKAPK20.29894025
120CSNK1E0.29449650
121DYRK1B0.27391467
122MTOR0.26038860
123BCKDK0.26034455
124CLK10.25917969
125RPS6KL10.24607611
126RPS6KC10.24607611
127FGFR10.24270961

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.95687836
2DNA replication_Homo sapiens_hsa030304.45983250
3Mismatch repair_Homo sapiens_hsa034303.82402412
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26176048
5Spliceosome_Homo sapiens_hsa030403.22617944
6Proteasome_Homo sapiens_hsa030503.05207141
7RNA polymerase_Homo sapiens_hsa030202.94723793
8RNA transport_Homo sapiens_hsa030132.82308001
9One carbon pool by folate_Homo sapiens_hsa006702.62783657
10Base excision repair_Homo sapiens_hsa034102.61441734
11Nucleotide excision repair_Homo sapiens_hsa034202.61288130
12Homologous recombination_Homo sapiens_hsa034402.58688031
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.40460186
14Pyrimidine metabolism_Homo sapiens_hsa002402.25688778
15Cell cycle_Homo sapiens_hsa041102.22324747
16Asthma_Homo sapiens_hsa053102.04644232
17Non-homologous end-joining_Homo sapiens_hsa034501.87893777
18Fanconi anemia pathway_Homo sapiens_hsa034601.67100274
19RNA degradation_Homo sapiens_hsa030181.65628882
20p53 signaling pathway_Homo sapiens_hsa041151.60777924
21Basal transcription factors_Homo sapiens_hsa030221.59021632
22mRNA surveillance pathway_Homo sapiens_hsa030151.49329593
23Allograft rejection_Homo sapiens_hsa053301.35180975
24Autoimmune thyroid disease_Homo sapiens_hsa053201.24071949
25Protein export_Homo sapiens_hsa030601.22015544
26Systemic lupus erythematosus_Homo sapiens_hsa053221.18790475
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15427336
28Epstein-Barr virus infection_Homo sapiens_hsa051691.14640012
29Antigen processing and presentation_Homo sapiens_hsa046121.13552369
30Sulfur relay system_Homo sapiens_hsa041221.07205715
31Purine metabolism_Homo sapiens_hsa002301.05050357
32Graft-versus-host disease_Homo sapiens_hsa053321.01928063
33Herpes simplex infection_Homo sapiens_hsa051680.99084058
34Thyroid cancer_Homo sapiens_hsa052160.98181601
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96391027
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.95129081
37Type I diabetes mellitus_Homo sapiens_hsa049400.92982341
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91273042
39Viral carcinogenesis_Homo sapiens_hsa052030.90658452
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79518733
41HTLV-I infection_Homo sapiens_hsa051660.79435292
42Cardiac muscle contraction_Homo sapiens_hsa042600.78613462
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76773370
44Small cell lung cancer_Homo sapiens_hsa052220.76282657
45Pyruvate metabolism_Homo sapiens_hsa006200.75531494
46Folate biosynthesis_Homo sapiens_hsa007900.75033449
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74106778
48Huntingtons disease_Homo sapiens_hsa050160.71866056
49Selenocompound metabolism_Homo sapiens_hsa004500.71471051
50Parkinsons disease_Homo sapiens_hsa050120.70873706
51Primary immunodeficiency_Homo sapiens_hsa053400.70007861
52Legionellosis_Homo sapiens_hsa051340.68619927
53MicroRNAs in cancer_Homo sapiens_hsa052060.67453036
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60761693
55Pentose phosphate pathway_Homo sapiens_hsa000300.59652741
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59629061
57Fatty acid elongation_Homo sapiens_hsa000620.58123018
58Bladder cancer_Homo sapiens_hsa052190.57633716
59Fat digestion and absorption_Homo sapiens_hsa049750.56174562
60TGF-beta signaling pathway_Homo sapiens_hsa043500.53865586
61Basal cell carcinoma_Homo sapiens_hsa052170.53850405
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53640826
63Apoptosis_Homo sapiens_hsa042100.52827034
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.51554459
65Metabolic pathways_Homo sapiens_hsa011000.51552144
66Oocyte meiosis_Homo sapiens_hsa041140.51444713
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51206986
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50986120
69Glutathione metabolism_Homo sapiens_hsa004800.50014769
70Biosynthesis of amino acids_Homo sapiens_hsa012300.49497572
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.49274109
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49067518
73Propanoate metabolism_Homo sapiens_hsa006400.48152836
74N-Glycan biosynthesis_Homo sapiens_hsa005100.47492810
75Chronic myeloid leukemia_Homo sapiens_hsa052200.45977284
76Hippo signaling pathway_Homo sapiens_hsa043900.45630249
77Measles_Homo sapiens_hsa051620.45393516
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45182627
79Oxidative phosphorylation_Homo sapiens_hsa001900.43843108
80Hematopoietic cell lineage_Homo sapiens_hsa046400.43439305
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42566663
82Hepatitis B_Homo sapiens_hsa051610.42042748
83Shigellosis_Homo sapiens_hsa051310.42014211
84Colorectal cancer_Homo sapiens_hsa052100.41305417
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40333837
86Alcoholism_Homo sapiens_hsa050340.37524652
87Acute myeloid leukemia_Homo sapiens_hsa052210.37475123
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.37184733
89Pathways in cancer_Homo sapiens_hsa052000.35654427
90Notch signaling pathway_Homo sapiens_hsa043300.35298774
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33714211
92HIF-1 signaling pathway_Homo sapiens_hsa040660.33355578
93Viral myocarditis_Homo sapiens_hsa054160.33049330
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32749702
95Vitamin digestion and absorption_Homo sapiens_hsa049770.32227993
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32192620
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30121915
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29360156
99Renin-angiotensin system_Homo sapiens_hsa046140.28285654
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.28240181
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26027090
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.25928846
103Carbon metabolism_Homo sapiens_hsa012000.25282310
104Influenza A_Homo sapiens_hsa051640.25119278
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25048142
106Sulfur metabolism_Homo sapiens_hsa009200.23829162
107Prostate cancer_Homo sapiens_hsa052150.23431645
108Galactose metabolism_Homo sapiens_hsa000520.23107097
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23103245
110Proteoglycans in cancer_Homo sapiens_hsa052050.23055271
111Adherens junction_Homo sapiens_hsa045200.22998914
112ECM-receptor interaction_Homo sapiens_hsa045120.22910073
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.21727659
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21121177
115Arachidonic acid metabolism_Homo sapiens_hsa005900.20941576
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.20831905
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20414316
118Hedgehog signaling pathway_Homo sapiens_hsa043400.18831140
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18826115
120Peroxisome_Homo sapiens_hsa041460.17511905
121Leishmaniasis_Homo sapiens_hsa051400.17312918
122Alzheimers disease_Homo sapiens_hsa050100.15552071
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15307923
124Wnt signaling pathway_Homo sapiens_hsa043100.15186188
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15007222
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14757959
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11845661
128Rheumatoid arthritis_Homo sapiens_hsa053230.11591160
129Fatty acid degradation_Homo sapiens_hsa000710.10783447
130B cell receptor signaling pathway_Homo sapiens_hsa046620.09303772
131Staphylococcus aureus infection_Homo sapiens_hsa051500.08102938
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06909902
133Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.06487335
134Caffeine metabolism_Homo sapiens_hsa002320.04525106

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