ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.95080412
2	ribosomal small subunit assembly (GO:0000028)	4.84214290
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.79002643
4	ATP synthesis coupled proton transport (GO:0015986)	4.79002643
5	viral transcription (GO:0019083)	4.71816096
6	translational termination (GO:0006415)	4.70477035
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.55059170
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.55059170
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.49507772
10	translational elongation (GO:0006414)	4.23053417
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.22523470
12	cotranslational protein targeting to membrane (GO:0006613)	4.15242574
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.13867589
14	protein targeting to ER (GO:0045047)	4.11950455
15	protein complex biogenesis (GO:0070271)	4.08609836
16	nucleotide salvage (GO:0043173)	4.00142386
17	chaperone-mediated protein transport (GO:0072321)	3.96350709
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.93734611
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.92395411
20	NADH dehydrogenase complex assembly (GO:0010257)	3.92395411
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.92395411
22	protein localization to endoplasmic reticulum (GO:0070972)	3.90989613
23	CTP metabolic process (GO:0046036)	3.89984925
24	CTP biosynthetic process (GO:0006241)	3.89984925
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.86880839
26	UMP metabolic process (GO:0046049)	3.80967849
27	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.80967849
28	UMP biosynthetic process (GO:0006222)	3.80967849
29	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.80967849
30	protein neddylation (GO:0045116)	3.75354994
31	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.63391608
32	maturation of SSU-rRNA (GO:0030490)	3.62889833
33	ribosomal large subunit biogenesis (GO:0042273)	3.62415616
34	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.56478425
35	cellular protein complex disassembly (GO:0043624)	3.51150359
36	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.45043490
37	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.41145272
38	respiratory electron transport chain (GO:0022904)	3.37988147
39	electron transport chain (GO:0022900)	3.34612508
40	nucleoside salvage (GO:0043174)	3.33640056
41	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.30779340
42	viral life cycle (GO:0019058)	3.30144770
43	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.28333450
44	DNA double-strand break processing (GO:0000729)	3.27856724
45	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.26244506
46	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.25771340
47	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.25240046
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.16748546
49	translational initiation (GO:0006413)	3.15921712
50	translation (GO:0006412)	3.15380000
51	aldehyde catabolic process (GO:0046185)	3.08494317
52	behavioral response to nicotine (GO:0035095)	3.06228598
53	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.02492081
54	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.02234930
55	fucose catabolic process (GO:0019317)	2.98331331
56	L-fucose metabolic process (GO:0042354)	2.98331331
57	L-fucose catabolic process (GO:0042355)	2.98331331
58	pyrimidine-containing compound salvage (GO:0008655)	2.91302631
59	pyrimidine nucleoside salvage (GO:0043097)	2.91302631
60	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.87319258
61	protein complex disassembly (GO:0043241)	2.82334114
62	negative regulation of heart rate (GO:0010459)	2.81886329
63	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.80306137
64	GTP biosynthetic process (GO:0006183)	2.79765143
65	platelet dense granule organization (GO:0060155)	2.76294715
66	macromolecular complex disassembly (GO:0032984)	2.75674605
67	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.73276247
68	positive regulation of protein homodimerization activity (GO:0090073)	2.73099630
69	termination of RNA polymerase III transcription (GO:0006386)	2.69907723
70	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69907723
71	S-adenosylmethionine metabolic process (GO:0046500)	2.69701489
72	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.68289496
73	protein targeting to membrane (GO:0006612)	2.68244914
74	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.64870794
75	cytidine deamination (GO:0009972)	2.64379740
76	cytidine metabolic process (GO:0046087)	2.64379740
77	cytidine catabolic process (GO:0006216)	2.64379740
78	regulation of hypersensitivity (GO:0002883)	2.63983823
79	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.63319811
80	hydrogen ion transmembrane transport (GO:1902600)	2.61802635
81	regulation of B cell receptor signaling pathway (GO:0050855)	2.58380635
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.58274210
83	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.57041396
84	piRNA metabolic process (GO:0034587)	2.55090893
85	ATP biosynthetic process (GO:0006754)	2.51487600
86	dopamine transport (GO:0015872)	2.50160947
87	respiratory chain complex IV assembly (GO:0008535)	2.50117410
88	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.49474401
89	negative regulation of mast cell activation (GO:0033004)	2.49402280
90	proton transport (GO:0015992)	2.49354262
91	ribosomal small subunit biogenesis (GO:0042274)	2.48535703
92	hydrogen transport (GO:0006818)	2.45193580
93	purine nucleotide salvage (GO:0032261)	2.45067056
94	nucleoside triphosphate biosynthetic process (GO:0009142)	2.44710069
95	tRNA processing (GO:0008033)	2.41979412
96	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.36331944
97	GPI anchor metabolic process (GO:0006505)	2.35291980
98	pyrimidine nucleoside biosynthetic process (GO:0046134)	2.33308194
99	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.31107677
100	mRNA catabolic process (GO:0006402)	2.30343703

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.57519530
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.13907923
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.13378507
4	VDR_22108803_ChIP-Seq_LS180_Human	2.92023566
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.69326708
6	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.60373135
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.54009489
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.46385829
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36694213
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34582110
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.18060866
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.16486353
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.15527735
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.13143641
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.08581323
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.08448228
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.07575168
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.02306826
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.01015992
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.97369090
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.96327316
22	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.85750844
23	P300_19829295_ChIP-Seq_ESCs_Human	1.85191028
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.85057854
25	EWS_26573619_Chip-Seq_HEK293_Human	1.81651163
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.81596632
27	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.77949210
28	FUS_26573619_Chip-Seq_HEK293_Human	1.71709276
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.70589266
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.67929637
31	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.65842238
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59644545
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.57027903
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.56208261
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50439681
36	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50217096
37	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.48349807
38	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48192957
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.47874440
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.46132849
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.43111165
42	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.42474994
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.42239698
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.41050907
45	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.40438386
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36060703
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36060703
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35956947
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.33940438
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.33940438
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33569478
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33569478
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33517681
54	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.33441284
55	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.33257110
56	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32538461
57	GATA3_26560356_Chip-Seq_TH2_Human	1.29836436
58	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29827396
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29406577
60	HTT_18923047_ChIP-ChIP_STHdh_Human	1.28958822
61	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27647665
62	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25001726
63	AR_20517297_ChIP-Seq_VCAP_Human	1.23383392
64	BCAT_22108803_ChIP-Seq_LS180_Human	1.22458447
65	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.22442373
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.22154903
67	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18407093
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18326305
69	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.17938205
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16280056
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15509700
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.13895306
73	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.11602773
74	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.10520759
75	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.08550028
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.08307573
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.06277027
78	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05931351
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05931351
80	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04643009
81	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04041589
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03971555
83	NCOR_22424771_ChIP-Seq_293T_Human	1.03803095
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03616590
85	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.01959503
86	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01369879
87	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.01017717
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00596037
89	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00338624
90	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.99938085
91	CMYC_18555785_Chip-Seq_ESCs_Mouse	0.98160614
92	TCF4_23295773_ChIP-Seq_U87_Human	0.98127708
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96930906
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96856499
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96037741
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95728721
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.95599281
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.95480052
99	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.94617720
100	AR_25329375_ChIP-Seq_VCAP_Human	0.94372997

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.05049583
2	MP0006292_abnormal_olfactory_placode	3.36734219
3	MP0001835_abnormal_antigen_presentation	3.01755406
4	MP0005671_abnormal_response_to	2.86867185
5	MP0002163_abnormal_gland_morphology	2.62080700
6	MP0003880_abnormal_central_pattern	2.61009363
7	MP0008875_abnormal_xenobiotic_pharmacok	2.49063410
8	MP0008872_abnormal_physiological_respon	2.41509100
9	MP0003787_abnormal_imprinting	2.38049179
10	MP0003646_muscle_fatigue	2.25257890
11	MP0003724_increased_susceptibility_to	2.17561238
12	MP0002736_abnormal_nociception_after	2.14613071
13	MP0001968_abnormal_touch/_nociception	2.02458849
14	MP0008877_abnormal_DNA_methylation	1.99896167
15	MP0000372_irregular_coat_pigmentation	1.86461535
16	MP0005379_endocrine/exocrine_gland_phen	1.74566223
17	MP0004142_abnormal_muscle_tone	1.73415115
18	MP0001873_stomach_inflammation	1.73123799
19	MP0002102_abnormal_ear_morphology	1.71156259
20	MP0001529_abnormal_vocalization	1.70882267
21	MP0001800_abnormal_humoral_immune	1.69496752
22	MP0006072_abnormal_retinal_apoptosis	1.64195941
23	MP0009785_altered_susceptibility_to	1.57029544
24	MP0005551_abnormal_eye_electrophysiolog	1.52964085
25	MP0005000_abnormal_immune_tolerance	1.47922184
26	MP0002234_abnormal_pharynx_morphology	1.47853597
27	MP0001919_abnormal_reproductive_system	1.46637733
28	MP0001790_abnormal_immune_system	1.45791299
29	MP0005387_immune_system_phenotype	1.45791299
30	MP0009764_decreased_sensitivity_to	1.44140096
31	MP0002148_abnormal_hypersensitivity_rea	1.42870093
32	MP0006082_CNS_inflammation	1.39067159
33	MP0001986_abnormal_taste_sensitivity	1.38275138
34	MP0001905_abnormal_dopamine_level	1.37826486
35	MP0004145_abnormal_muscle_electrophysio	1.37536968
36	MP0002095_abnormal_skin_pigmentation	1.37319891
37	MP0000685_abnormal_immune_system	1.36796529
38	MP0005389_reproductive_system_phenotype	1.34112658
39	MP0006276_abnormal_autonomic_nervous	1.33625613
40	MP0002272_abnormal_nervous_system	1.32739990
41	MP0005084_abnormal_gallbladder_morpholo	1.32029444
42	MP0001486_abnormal_startle_reflex	1.31875438
43	MP0004147_increased_porphyrin_level	1.31382313
44	MP0008789_abnormal_olfactory_epithelium	1.29096192
45	MP0002723_abnormal_immune_serum	1.23652631
46	MP0002638_abnormal_pupillary_reflex	1.22810373
47	MP0002452_abnormal_antigen_presenting	1.22038029
48	MP0002735_abnormal_chemical_nociception	1.21921152
49	MP0009745_abnormal_behavioral_response	1.20725342
50	MP0005645_abnormal_hypothalamus_physiol	1.19264253
51	MP0004742_abnormal_vestibular_system	1.19225245
52	MP0002837_dystrophic_cardiac_calcinosis	1.17229292
53	MP0005360_urolithiasis	1.16189419
54	MP0005423_abnormal_somatic_nervous	1.16004720
55	MP0005075_abnormal_melanosome_morpholog	1.15415053
56	MP0005646_abnormal_pituitary_gland	1.14648250
57	MP0003121_genomic_imprinting	1.13259784
58	MP0001819_abnormal_immune_cell	1.12448903
59	MP0003806_abnormal_nucleotide_metabolis	1.11267682
60	MP0002420_abnormal_adaptive_immunity	1.11100221
61	MP0001984_abnormal_olfaction	1.10078483
62	MP0001970_abnormal_pain_threshold	1.09460678
63	MP0002166_altered_tumor_susceptibility	1.03509139
64	MP0005253_abnormal_eye_physiology	1.00410800
65	MP0004885_abnormal_endolymph	0.99773799
66	MP0000631_abnormal_neuroendocrine_gland	0.96806721
67	MP0002160_abnormal_reproductive_system	0.96275300
68	MP0000569_abnormal_digit_pigmentation	0.94498121
69	MP0005499_abnormal_olfactory_system	0.93834781
70	MP0005394_taste/olfaction_phenotype	0.93834781
71	MP0008995_early_reproductive_senescence	0.93435887
72	MP0001348_abnormal_lacrimal_gland	0.92294367
73	MP0003195_calcinosis	0.91590882
74	MP0001293_anophthalmia	0.90196609
75	MP0001485_abnormal_pinna_reflex	0.88986595
76	MP0005025_abnormal_response_to	0.88346720
77	MP0010155_abnormal_intestine_physiology	0.88285576
78	MP0003763_abnormal_thymus_physiology	0.85926235
79	MP0005174_abnormal_tail_pigmentation	0.85620321
80	MP0000716_abnormal_immune_system	0.85491641
81	MP0001440_abnormal_grooming_behavior	0.85333162
82	MP0001764_abnormal_homeostasis	0.84453659
83	MP0002006_tumorigenesis	0.83998055
84	MP0005367_renal/urinary_system_phenotyp	0.83426596
85	MP0000516_abnormal_urinary_system	0.83426596
86	MP0003136_yellow_coat_color	0.82367977
87	MP0001501_abnormal_sleep_pattern	0.81938933
88	MP0004043_abnormal_pH_regulation	0.81179998
89	MP0005310_abnormal_salivary_gland	0.78846723
90	MP0002557_abnormal_social/conspecific_i	0.77770890
91	MP0002572_abnormal_emotion/affect_behav	0.76942568
92	MP0001756_abnormal_urination	0.76875794
93	MP0002398_abnormal_bone_marrow	0.76742449
94	MP0005195_abnormal_posterior_eye	0.76149681
95	MP0005167_abnormal_blood-brain_barrier	0.75572964
96	MP0005636_abnormal_mineral_homeostasis	0.74870957
97	MP0003567_abnormal_fetal_cardiomyocyte	0.73964847
98	MP0001845_abnormal_inflammatory_respons	0.72778168
99	MP0003186_abnormal_redox_activity	0.71240232
100	MP0003635_abnormal_synaptic_transmissio	0.68178288

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.86374030
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.25686405
3	Mitochondrial inheritance (HP:0001427)	4.22867764
4	Progressive macrocephaly (HP:0004481)	4.07127504
5	Acute encephalopathy (HP:0006846)	4.04280991
6	Increased hepatocellular lipid droplets (HP:0006565)	3.90373039
7	Increased CSF lactate (HP:0002490)	3.81208390
8	Lipid accumulation in hepatocytes (HP:0006561)	3.64452452
9	Hepatocellular necrosis (HP:0001404)	3.53706182
10	Type II lissencephaly (HP:0007260)	3.44194276
11	3-Methylglutaconic aciduria (HP:0003535)	3.44062911
12	Hepatic necrosis (HP:0002605)	3.14045619
13	Congenital stationary night blindness (HP:0007642)	3.10080487
14	Cerebral edema (HP:0002181)	3.04032022
15	Exertional dyspnea (HP:0002875)	2.99306707
16	Hypoproteinemia (HP:0003075)	2.99050286
17	Renal Fanconi syndrome (HP:0001994)	2.96095556
18	IgG deficiency (HP:0004315)	2.82028038
19	Abolished electroretinogram (ERG) (HP:0000550)	2.72760745
20	Abnormality of midbrain morphology (HP:0002418)	2.70601317
21	Molar tooth sign on MRI (HP:0002419)	2.70601317
22	Pancreatic cysts (HP:0001737)	2.65726087
23	Increased intramyocellular lipid droplets (HP:0012240)	2.64043379
24	Congenital, generalized hypertrichosis (HP:0004540)	2.60028590
25	Optic disc pallor (HP:0000543)	2.59918573
26	Reticulocytopenia (HP:0001896)	2.59879900
27	Stenosis of the external auditory canal (HP:0000402)	2.57777060
28	Severe combined immunodeficiency (HP:0004430)	2.57536780
29	Increased serum lactate (HP:0002151)	2.41655872
30	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41475955
31	Panhypogammaglobulinemia (HP:0003139)	2.41394049
32	Abnormality of B cell number (HP:0010975)	2.40484288
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.38365181
34	Absent/shortened dynein arms (HP:0200106)	2.38365181
35	Pancreatic fibrosis (HP:0100732)	2.36746726
36	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.34805445
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.34715341
38	Dyskinesia (HP:0100660)	2.34356493
39	Increased IgM level (HP:0003496)	2.32493995
40	Leukodystrophy (HP:0002415)	2.22189968
41	B lymphocytopenia (HP:0010976)	2.20026475
42	Macrocytic anemia (HP:0001972)	2.16745473
43	Increased muscle lipid content (HP:0009058)	2.16278948
44	Abnormality of the prostate (HP:0008775)	2.15926913
45	Abnormal rod and cone electroretinograms (HP:0008323)	2.15789260
46	Thyroiditis (HP:0100646)	2.14380971
47	Lactic acidosis (HP:0003128)	2.12136858
48	Respiratory failure (HP:0002878)	2.08274912
49	Abnormality of renal resorption (HP:0011038)	2.08218343
50	Type 2 muscle fiber atrophy (HP:0003554)	2.08146183
51	Abnormality of the labia minora (HP:0012880)	2.06516418
52	Poor suck (HP:0002033)	2.04871000
53	True hermaphroditism (HP:0010459)	2.03620656
54	Hypoplasia of the pons (HP:0012110)	2.00013899
55	Medial flaring of the eyebrow (HP:0010747)	1.99965826
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99575386
57	Hip dysplasia (HP:0001385)	1.98768257
58	Nephronophthisis (HP:0000090)	1.98764244
59	Hemoptysis (HP:0002105)	1.97982733
60	Lissencephaly (HP:0001339)	1.97887663
61	Pallor (HP:0000980)	1.96921849
62	Abnormality of urine glucose concentration (HP:0011016)	1.94856380
63	Glycosuria (HP:0003076)	1.94856380
64	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.94621588
65	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.94621588
66	Hyperglycinemia (HP:0002154)	1.92947266
67	Decreased central vision (HP:0007663)	1.88416027
68	Encephalitis (HP:0002383)	1.88176623
69	Methylmalonic acidemia (HP:0002912)	1.87990525
70	Absent thumb (HP:0009777)	1.87978469
71	Lethargy (HP:0001254)	1.86457908
72	Retinal dysplasia (HP:0007973)	1.85111451
73	Exercise intolerance (HP:0003546)	1.84839452
74	Hyperphosphaturia (HP:0003109)	1.83748427
75	Abnormal number of erythroid precursors (HP:0012131)	1.83344562
76	Constricted visual fields (HP:0001133)	1.82952841
77	Abnormality of eosinophils (HP:0001879)	1.82913711
78	Abnormal ciliary motility (HP:0012262)	1.81902268
79	Respiratory difficulties (HP:0002880)	1.81520602
80	Elevated erythrocyte sedimentation rate (HP:0003565)	1.81313005
81	Opisthotonus (HP:0002179)	1.80788438
82	Progressive microcephaly (HP:0000253)	1.78719943
83	Combined immunodeficiency (HP:0005387)	1.77855002
84	Genetic anticipation (HP:0003743)	1.77636984
85	Attenuation of retinal blood vessels (HP:0007843)	1.75768336
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73141110
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.73141110
88	Concave nail (HP:0001598)	1.72740917
89	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.72394469
90	Abnormality of the pons (HP:0007361)	1.72161561
91	Cerebellar dysplasia (HP:0007033)	1.71194550
92	CNS demyelination (HP:0007305)	1.71165956
93	Colon cancer (HP:0003003)	1.70189735
94	Bile duct proliferation (HP:0001408)	1.69669590
95	Abnormal biliary tract physiology (HP:0012439)	1.69669590
96	Chronic mucocutaneous candidiasis (HP:0002728)	1.69652760
97	Recurrent cutaneous fungal infections (HP:0011370)	1.69652760
98	X-linked dominant inheritance (HP:0001423)	1.69290622
99	Conical tooth (HP:0000698)	1.69227283
100	Parakeratosis (HP:0001036)	1.67012730

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.44999026
2	WNK3	3.26439779
3	NUAK1	3.25134878
4	MAP4K2	2.66529085
5	TXK	2.59805122
6	PINK1	2.48507465
7	TIE1	2.45477450
8	TLK1	2.37010146
9	ADRBK2	2.36975373
10	FRK	2.26811678
11	BCKDK	2.24296669
12	BMPR2	2.02280824
13	WNK4	2.00725404
14	MAP3K12	1.87340465
15	TEC	1.82637538
16	STK39	1.80326140
17	CCNB1	1.80306936
18	GRK1	1.76771354
19	TRIM28	1.71302862
20	OXSR1	1.69270150
21	TAOK3	1.61895859
22	LIMK1	1.61003279
23	KDR	1.52054447
24	VRK2	1.50917670
25	MAP3K4	1.40098174
26	BMPR1B	1.34685418
27	ZAK	1.25794164
28	MAP2K7	1.22197539
29	EIF2AK3	1.17469906
30	MYLK	1.15152708
31	INSRR	1.14844153
32	MAPK13	1.13519213
33	ITK	1.12173108
34	DYRK2	1.06649245
35	CSF1R	1.06170632
36	ACVR1B	1.01034713
37	ILK	1.00602147
38	MAP4K1	0.99769902
39	STK16	0.99587706
40	SIK2	0.99207688
41	KIT	0.98116103
42	CSNK1G1	0.96204548
43	NEK1	0.95782345
44	ERBB3	0.95329345
45	SYK	0.95251601
46	VRK1	0.92893073
47	GRK6	0.86698003
48	IKBKB	0.85043967
49	OBSCN	0.79746140
50	NLK	0.79089647
51	MARK1	0.74238489
52	PLK2	0.74201363
53	BCR	0.73352126
54	ADRBK1	0.72008785
55	PRKCQ	0.71389324
56	EIF2AK2	0.70621826
57	PRKCG	0.66877482
58	LYN	0.66641610
59	CSNK1G3	0.65954803
60	PLK4	0.65562564
61	PIK3CA	0.63665470
62	BTK	0.62412484
63	FLT3	0.60954060
64	CSNK2A2	0.58940865
65	STK38L	0.58108707
66	RPS6KA5	0.55058281
67	PKN1	0.54367128
68	LCK	0.53692987
69	MST4	0.50615887
70	CSNK1G2	0.50404205
71	PAK3	0.50138379
72	TNIK	0.49082772
73	PRKACA	0.48882054
74	CSNK2A1	0.48191809
75	ROCK1	0.48181206
76	JAK3	0.48111338
77	FES	0.47975674
78	PRKCE	0.47841480
79	GRK5	0.47196850
80	BRD4	0.47116274
81	MINK1	0.47096294
82	PIM1	0.46136547
83	TESK1	0.45786460
84	DAPK3	0.44390775
85	IGF1R	0.44222492
86	TRPM7	0.43922868
87	CSNK1A1L	0.43411165
88	PIK3CG	0.43379508
89	TNK2	0.43267584
90	SCYL2	0.43178685
91	CDK8	0.43050406
92	MKNK1	0.42709675
93	NTRK2	0.42631974
94	MAP3K14	0.42154750
95	CASK	0.41597725
96	CSNK1A1	0.41564983
97	PRKCA	0.41384948
98	DAPK1	0.40073091
99	PRKG1	0.38720354
100	CAMK2A	0.38395374

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.23714635
2	Ribosome_Homo sapiens_hsa03010	3.73757492
3	Allograft rejection_Homo sapiens_hsa05330	3.40313660
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.24984098
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17896303
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.03584027
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.99657160
8	Proteasome_Homo sapiens_hsa03050	2.94148667
9	Parkinsons disease_Homo sapiens_hsa05012	2.76271329
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.65257472
11	Protein export_Homo sapiens_hsa03060	2.31828095
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.16080773
13	Antigen processing and presentation_Homo sapiens_hsa04612	1.83094277
14	Alzheimers disease_Homo sapiens_hsa05010	1.77653612
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.76906421
16	RNA polymerase_Homo sapiens_hsa03020	1.76741760
17	Huntingtons disease_Homo sapiens_hsa05016	1.61693245
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56465151
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.53574029
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.44149446
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43767407
22	Caffeine metabolism_Homo sapiens_hsa00232	1.40199417
23	Phototransduction_Homo sapiens_hsa04744	1.39730824
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35992035
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.34271441
26	Homologous recombination_Homo sapiens_hsa03440	1.30348098
27	Viral myocarditis_Homo sapiens_hsa05416	1.27026947
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.24679656
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.24552052
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.24015879
31	Sulfur relay system_Homo sapiens_hsa04122	1.22023945
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18726359
33	Butanoate metabolism_Homo sapiens_hsa00650	1.17121024
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.14733180
35	RNA degradation_Homo sapiens_hsa03018	1.14689163
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.08883852
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02908255
38	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01451382
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00927707
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99746154
41	Propanoate metabolism_Homo sapiens_hsa00640	0.98407125
42	Olfactory transduction_Homo sapiens_hsa04740	0.95705920
43	Non-homologous end-joining_Homo sapiens_hsa03450	0.95206480
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94690032
45	One carbon pool by folate_Homo sapiens_hsa00670	0.94428776
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.87022605
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.86536761
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.85035416
49	Nicotine addiction_Homo sapiens_hsa05033	0.81095142
50	Peroxisome_Homo sapiens_hsa04146	0.80772587
51	Leishmaniasis_Homo sapiens_hsa05140	0.79989173
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.79012551
53	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.77975044
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77402233
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.76645189
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.73417032
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72638947
58	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.71880172
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.67064453
60	Purine metabolism_Homo sapiens_hsa00230	0.64297589
61	DNA replication_Homo sapiens_hsa03030	0.63954873
62	Mismatch repair_Homo sapiens_hsa03430	0.60238098
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60236119
64	Basal transcription factors_Homo sapiens_hsa03022	0.57158827
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.56943434
66	Regulation of autophagy_Homo sapiens_hsa04140	0.56676738
67	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.56395621
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52846301
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.52110151
70	Retinol metabolism_Homo sapiens_hsa00830	0.51514116
71	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.50294233
72	Morphine addiction_Homo sapiens_hsa05032	0.47803634
73	Taste transduction_Homo sapiens_hsa04742	0.47511690
74	Salivary secretion_Homo sapiens_hsa04970	0.46329964
75	Metabolic pathways_Homo sapiens_hsa01100	0.45726964
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44934928
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44799253
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44745964
79	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43914897
80	RNA transport_Homo sapiens_hsa03013	0.43448343
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42043475
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41447701
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.40312128
84	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.39371034
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38992897
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31282686
87	Fatty acid degradation_Homo sapiens_hsa00071	0.29347391
88	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27863775
89	Herpes simplex infection_Homo sapiens_hsa05168	0.27585073
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27351626
91	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.26900918
92	Measles_Homo sapiens_hsa05162	0.26789763
93	Spliceosome_Homo sapiens_hsa03040	0.25946022
94	GABAergic synapse_Homo sapiens_hsa04727	0.24827966
95	Circadian entrainment_Homo sapiens_hsa04713	0.24396322
96	Phagosome_Homo sapiens_hsa04145	0.23490703
97	Tuberculosis_Homo sapiens_hsa05152	0.22949089
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.22918746
99	Serotonergic synapse_Homo sapiens_hsa04726	0.22275064
100	Glutathione metabolism_Homo sapiens_hsa00480	0.21961762

EEF1B2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »