ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein K11-linked deubiquitination (GO:0035871)	4.89228303
2	DNA double-strand break processing (GO:0000729)	4.36595104
3	replication fork processing (GO:0031297)	4.24298035
4	DNA deamination (GO:0045006)	4.04174817
5	proteasome assembly (GO:0043248)	3.80962682
6	ribosomal small subunit assembly (GO:0000028)	3.79101184
7	protein complex biogenesis (GO:0070271)	3.66177138
8	response to pheromone (GO:0019236)	3.55015765
9	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.54095899
10	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.49515940
11	synapsis (GO:0007129)	3.43537794
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.41468770
13	respiratory chain complex IV assembly (GO:0008535)	3.31209361
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.31120888
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.31120888
16	NADH dehydrogenase complex assembly (GO:0010257)	3.31120888
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.27714795
18	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.19021499
19	cytochrome complex assembly (GO:0017004)	3.18661321
20	protein-cofactor linkage (GO:0018065)	3.18348228
21	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.18259519
22	piRNA metabolic process (GO:0034587)	3.15926863
23	serotonin receptor signaling pathway (GO:0007210)	3.14153167
24	platelet dense granule organization (GO:0060155)	3.14063374
25	protein K6-linked ubiquitination (GO:0085020)	3.10306993
26	chromatin remodeling at centromere (GO:0031055)	3.09765356
27	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.09391455
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.08897526
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.08897526
30	DNA catabolic process, exonucleolytic (GO:0000738)	3.06311814
31	recombinational repair (GO:0000725)	3.06102563
32	double-strand break repair via homologous recombination (GO:0000724)	3.05422779
33	water-soluble vitamin biosynthetic process (GO:0042364)	3.04558569
34	rRNA catabolic process (GO:0016075)	3.00746468
35	pseudouridine synthesis (GO:0001522)	2.97382264
36	CENP-A containing nucleosome assembly (GO:0034080)	2.92985146
37	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.90753320
38	otic vesicle formation (GO:0030916)	2.89831301
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.89697050
40	telomere maintenance via semi-conservative replication (GO:0032201)	2.89147943
41	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.86358044
42	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.80055499
43	centriole replication (GO:0007099)	2.78722903
44	regulation of meiosis I (GO:0060631)	2.74427140
45	indole-containing compound catabolic process (GO:0042436)	2.74173559
46	indolalkylamine catabolic process (GO:0046218)	2.74173559
47	tryptophan catabolic process (GO:0006569)	2.74173559
48	S-adenosylmethionine metabolic process (GO:0046500)	2.73104499
49	telomere maintenance via recombination (GO:0000722)	2.72872545
50	branched-chain amino acid catabolic process (GO:0009083)	2.72109939
51	nucleobase biosynthetic process (GO:0046112)	2.69199612
52	sulfation (GO:0051923)	2.68077527
53	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.67717317
54	termination of RNA polymerase III transcription (GO:0006386)	2.67434506
55	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.67434506
56	behavioral response to nicotine (GO:0035095)	2.66890688
57	maturation of 5.8S rRNA (GO:0000460)	2.66835630
58	CTP biosynthetic process (GO:0006241)	2.66761526
59	CTP metabolic process (GO:0046036)	2.66761526
60	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.65735283
61	indolalkylamine metabolic process (GO:0006586)	2.65129636
62	histone exchange (GO:0043486)	2.64114399
63	postreplication repair (GO:0006301)	2.63334618
64	aldehyde catabolic process (GO:0046185)	2.63007948
65	histone mRNA metabolic process (GO:0008334)	2.59388288
66	mitotic recombination (GO:0006312)	2.58229416
67	GTP biosynthetic process (GO:0006183)	2.57651831
68	prenylation (GO:0097354)	2.56517984
69	protein prenylation (GO:0018342)	2.56517984
70	purine nucleobase biosynthetic process (GO:0009113)	2.55744246
71	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.55689661
72	ATP synthesis coupled proton transport (GO:0015986)	2.55689661
73	lactate metabolic process (GO:0006089)	2.55513852
74	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.55222749
75	tryptophan metabolic process (GO:0006568)	2.55180933
76	regulation of cellular amino acid metabolic process (GO:0006521)	2.55126985
77	DNA replication-dependent nucleosome assembly (GO:0006335)	2.54714645
78	DNA replication-dependent nucleosome organization (GO:0034723)	2.54714645
79	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.54237646
80	regulation of appetite (GO:0032098)	2.53758088
81	mannosylation (GO:0097502)	2.52769125
82	axoneme assembly (GO:0035082)	2.52561370
83	DNA replication checkpoint (GO:0000076)	2.49565090
84	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.49431455
85	L-methionine salvage (GO:0071267)	2.49301819
86	L-methionine biosynthetic process (GO:0071265)	2.49301819
87	amino acid salvage (GO:0043102)	2.49301819
88	intra-S DNA damage checkpoint (GO:0031573)	2.49280045
89	thyroid hormone metabolic process (GO:0042403)	2.48291224
90	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.47042118
91	L-fucose metabolic process (GO:0042354)	2.46047896
92	L-fucose catabolic process (GO:0042355)	2.46047896
93	fucose catabolic process (GO:0019317)	2.46047896
94	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.45738563
95	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.45738563
96	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.45738563
97	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.45633543
98	protein neddylation (GO:0045116)	2.45325508
99	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.44991206
100	rRNA modification (GO:0000154)	2.42407906

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.80328086
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.30519328
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.29286958
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.13284865
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99067136
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.77832356
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.74020120
8	VDR_22108803_ChIP-Seq_LS180_Human	2.69738492
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.52039881
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43934944
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41656462
12	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.40476564
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.27800336
14	EWS_26573619_Chip-Seq_HEK293_Human	2.25601941
15	FUS_26573619_Chip-Seq_HEK293_Human	2.16018932
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.15305228
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.09571595
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.08433459
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98248383
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.95472839
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.94290713
22	TAF15_26573619_Chip-Seq_HEK293_Human	1.88310238
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.84267902
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.84176469
25	P300_19829295_ChIP-Seq_ESCs_Human	1.82323648
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82007401
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.81784021
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.78197043
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.77968802
30	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.69881080
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68763035
32	IRF1_19129219_ChIP-ChIP_H3396_Human	1.67779847
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.65679708
34	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63726824
35	ER_23166858_ChIP-Seq_MCF-7_Human	1.62721925
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62082965
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59065272
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.53374892
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.52842975
40	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.45634036
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45528718
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.45338133
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44251543
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39585041
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39585041
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37802509
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.37113350
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37113350
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.36833409
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36709897
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36283646
52	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34583087
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30759567
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30743302
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.30643938
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.28952269
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.28049654
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.28049654
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27456840
60	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25000280
61	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.23286047
62	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21823411
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.20342180
64	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20338374
65	AR_25329375_ChIP-Seq_VCAP_Human	1.19892093
66	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19560501
67	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.18561206
68	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.18500952
69	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15420729
70	AR_20517297_ChIP-Seq_VCAP_Human	1.10258551
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10155038
72	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08304533
73	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.07022746
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.06221924
75	NCOR_22424771_ChIP-Seq_293T_Human	1.06168269
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05647513
77	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04547939
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.02341841
79	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.02162004
80	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.01669660
81	STAT3_23295773_ChIP-Seq_U87_Human	1.01237357
82	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00715597
83	CDX2_22108803_ChIP-Seq_LS180_Human	1.00283607
84	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00234528
85	PHF8_20622853_ChIP-Seq_HELA_Human	0.98624560
86	TCF4_23295773_ChIP-Seq_U87_Human	0.98371992
87	TTF2_22483619_ChIP-Seq_HELA_Human	0.97859400
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.97334512
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96570303
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96135283
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94137985
92	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92679496
93	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92103313
94	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.91617734
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.91611344
96	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.91385186
97	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.90938960
98	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.90699202
99	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90197393
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89678413

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.63673801
2	MP0008877_abnormal_DNA_methylation	3.05459321
3	MP0000372_irregular_coat_pigmentation	2.89324824
4	MP0002102_abnormal_ear_morphology	2.79432438
5	MP0008058_abnormal_DNA_repair	2.43867621
6	MP0010094_abnormal_chromosome_stability	2.41813098
7	MP0003646_muscle_fatigue	2.30415915
8	MP0008995_early_reproductive_senescence	2.24416959
9	MP0005551_abnormal_eye_electrophysiolog	2.24334427
10	MP0003806_abnormal_nucleotide_metabolis	2.18955147
11	MP0006072_abnormal_retinal_apoptosis	2.17399862
12	MP0003195_calcinosis	2.14674999
13	MP0008875_abnormal_xenobiotic_pharmacok	2.01569255
14	MP0004147_increased_porphyrin_level	1.97113495
15	MP0002736_abnormal_nociception_after	1.91076562
16	MP0002938_white_spotting	1.77350164
17	MP0008872_abnormal_physiological_respon	1.75042278
18	MP0003786_premature_aging	1.72824118
19	MP0005389_reproductive_system_phenotype	1.72274980
20	MP0002138_abnormal_hepatobiliary_system	1.67409778
21	MP0005084_abnormal_gallbladder_morpholo	1.67160242
22	MP0002837_dystrophic_cardiac_calcinosis	1.67046243
23	MP0001293_anophthalmia	1.66190194
24	MP0002254_reproductive_system_inflammat	1.65796406
25	MP0003718_maternal_effect	1.65773193
26	MP0001764_abnormal_homeostasis	1.61800851
27	MP0003693_abnormal_embryo_hatching	1.61603550
28	MP0005075_abnormal_melanosome_morpholog	1.61058003
29	MP0003787_abnormal_imprinting	1.59952972
30	MP0005253_abnormal_eye_physiology	1.59787536
31	MP0001919_abnormal_reproductive_system	1.57926759
32	MP0009379_abnormal_foot_pigmentation	1.54235001
33	MP0001968_abnormal_touch/_nociception	1.49483230
34	MP0003880_abnormal_central_pattern	1.48523233
35	MP0003136_yellow_coat_color	1.48012150
36	MP0002095_abnormal_skin_pigmentation	1.46215696
37	MP0006276_abnormal_autonomic_nervous	1.46172613
38	MP0001984_abnormal_olfaction	1.42479294
39	MP0005174_abnormal_tail_pigmentation	1.40344055
40	MP0004142_abnormal_muscle_tone	1.39743719
41	MP0005645_abnormal_hypothalamus_physiol	1.39160278
42	MP0002638_abnormal_pupillary_reflex	1.36737931
43	MP0001485_abnormal_pinna_reflex	1.34446935
44	MP0005646_abnormal_pituitary_gland	1.33768647
45	MP0002160_abnormal_reproductive_system	1.32702804
46	MP0005377_hearing/vestibular/ear_phenot	1.26534181
47	MP0003878_abnormal_ear_physiology	1.26534181
48	MP0000631_abnormal_neuroendocrine_gland	1.25235414
49	MP0001873_stomach_inflammation	1.23399059
50	MP0009697_abnormal_copulation	1.20671299
51	MP0003186_abnormal_redox_activity	1.20468506
52	MP0001986_abnormal_taste_sensitivity	1.19730888
53	MP0002876_abnormal_thyroid_physiology	1.19189224
54	MP0002234_abnormal_pharynx_morphology	1.18846759
55	MP0005671_abnormal_response_to	1.13693125
56	MP0003121_genomic_imprinting	1.11851230
57	MP0002210_abnormal_sex_determination	1.11014691
58	MP0004043_abnormal_pH_regulation	1.09013972
59	MP0000516_abnormal_urinary_system	1.08068154
60	MP0005367_renal/urinary_system_phenotyp	1.08068154
61	MP0001486_abnormal_startle_reflex	1.07459800
62	MP0001929_abnormal_gametogenesis	1.07382879
63	MP0008057_abnormal_DNA_replication	1.06213231
64	MP0001119_abnormal_female_reproductive	1.06123360
65	MP0002163_abnormal_gland_morphology	1.04642494
66	MP0004145_abnormal_muscle_electrophysio	1.03620279
67	MP0004957_abnormal_blastocyst_morpholog	1.02915425
68	MP0000639_abnormal_adrenal_gland	1.01627885
69	MP0008789_abnormal_olfactory_epithelium	1.01135475
70	MP0000653_abnormal_sex_gland	1.00549301
71	MP0000427_abnormal_hair_cycle	0.96117494
72	MP0001145_abnormal_male_reproductive	0.95235662
73	MP0003567_abnormal_fetal_cardiomyocyte	0.95137477
74	MP0005410_abnormal_fertilization	0.95089480
75	MP0005670_abnormal_white_adipose	0.92322348
76	MP0000613_abnormal_salivary_gland	0.90263786
77	MP0006036_abnormal_mitochondrial_physio	0.90005550
78	MP0001529_abnormal_vocalization	0.89028724
79	MP0001501_abnormal_sleep_pattern	0.87973278
80	MP0003698_abnormal_male_reproductive	0.87055503
81	MP0005195_abnormal_posterior_eye	0.81701927
82	MP0009745_abnormal_behavioral_response	0.81269245
83	MP0002272_abnormal_nervous_system	0.81202793
84	MP0009046_muscle_twitch	0.80296608
85	MP0005408_hypopigmentation	0.80285626
86	MP0002277_abnormal_respiratory_mucosa	0.80195542
87	MP0003937_abnormal_limbs/digits/tail_de	0.79844742
88	MP0005636_abnormal_mineral_homeostasis	0.79320825
89	MP0002233_abnormal_nose_morphology	0.76002456
90	MP0003943_abnormal_hepatobiliary_system	0.75179553
91	MP0006035_abnormal_mitochondrial_morpho	0.74986504
92	MP0000015_abnormal_ear_pigmentation	0.73466027
93	MP0005391_vision/eye_phenotype	0.71556726
94	MP0001905_abnormal_dopamine_level	0.71395616
95	MP0004885_abnormal_endolymph	0.70947602
96	MP0005332_abnormal_amino_acid	0.70611522
97	MP0003137_abnormal_impulse_conducting	0.70182793
98	MP0001324_abnormal_eye_pigmentation	0.70006734
99	MP0005310_abnormal_salivary_gland	0.68821591
100	MP0004215_abnormal_myocardial_fiber	0.67505091

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.77969130
2	True hermaphroditism (HP:0010459)	3.72762482
3	Molar tooth sign on MRI (HP:0002419)	3.52915815
4	Abnormality of midbrain morphology (HP:0002418)	3.52915815
5	Pancreatic fibrosis (HP:0100732)	3.39997520
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.38752379
7	Congenital stationary night blindness (HP:0007642)	3.27344786
8	Attenuation of retinal blood vessels (HP:0007843)	3.00255953
9	Acute necrotizing encephalopathy (HP:0006965)	2.99792176
10	Increased CSF lactate (HP:0002490)	2.96263857
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.95977904
12	Abnormal rod and cone electroretinograms (HP:0008323)	2.95665869
13	Mitochondrial inheritance (HP:0001427)	2.94545246
14	Acute encephalopathy (HP:0006846)	2.90806389
15	Abolished electroretinogram (ERG) (HP:0000550)	2.78140825
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.74419025
17	Chromsome breakage (HP:0040012)	2.74202769
18	Hyperglycinemia (HP:0002154)	2.72223367
19	Hepatocellular necrosis (HP:0001404)	2.71434559
20	Nephronophthisis (HP:0000090)	2.70643000
21	Abnormality of the labia minora (HP:0012880)	2.65997241
22	Abnormality of the ileum (HP:0001549)	2.65957348
23	Meckel diverticulum (HP:0002245)	2.64721389
24	Abnormality of chromosome stability (HP:0003220)	2.59809013
25	Progressive macrocephaly (HP:0004481)	2.57298621
26	Increased hepatocellular lipid droplets (HP:0006565)	2.56693614
27	Abnormal mitochondria in muscle tissue (HP:0008316)	2.51357816
28	Lipid accumulation in hepatocytes (HP:0006561)	2.44530830
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.42196800
30	Hepatic necrosis (HP:0002605)	2.38843060
31	Abnormality of DNA repair (HP:0003254)	2.38345035
32	Abnormality of the preputium (HP:0100587)	2.37923870
33	Decreased central vision (HP:0007663)	2.37127504
34	Medial flaring of the eyebrow (HP:0010747)	2.36138272
35	Reticulocytopenia (HP:0001896)	2.34110140
36	Colon cancer (HP:0003003)	2.31899826
37	Male pseudohermaphroditism (HP:0000037)	2.31677986
38	Chronic hepatic failure (HP:0100626)	2.30870111
39	Pendular nystagmus (HP:0012043)	2.27778427
40	Cerebral edema (HP:0002181)	2.25151851
41	3-Methylglutaconic aciduria (HP:0003535)	2.20146575
42	Abnormality of the renal medulla (HP:0100957)	2.19694313
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.18733616
44	Bile duct proliferation (HP:0001408)	2.17658436
45	Abnormal biliary tract physiology (HP:0012439)	2.17658436
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.16449657
47	Cystic liver disease (HP:0006706)	2.13310694
48	Absent thumb (HP:0009777)	2.11941105
49	Optic disc pallor (HP:0000543)	2.11929853
50	Severe combined immunodeficiency (HP:0004430)	2.10254933
51	Constricted visual fields (HP:0001133)	2.09207744
52	Septo-optic dysplasia (HP:0100842)	2.08820201
53	Abnormality of serine family amino acid metabolism (HP:0010894)	2.08595094
54	Abnormality of glycine metabolism (HP:0010895)	2.08595094
55	Triphalangeal thumb (HP:0001199)	2.07529793
56	Asplenia (HP:0001746)	2.06926323
57	Sclerocornea (HP:0000647)	2.06587111
58	Hyperglycinuria (HP:0003108)	2.05900887
59	Clubbing of toes (HP:0100760)	2.03301449
60	Methylmalonic acidemia (HP:0002912)	2.03139547
61	Abnormality of the renal cortex (HP:0011035)	2.02819815
62	Thyroiditis (HP:0100646)	2.00834515
63	Congenital primary aphakia (HP:0007707)	2.00144232
64	Sloping forehead (HP:0000340)	1.99668269
65	Duodenal stenosis (HP:0100867)	1.99449931
66	Small intestinal stenosis (HP:0012848)	1.99449931
67	Abnormality of the renal collecting system (HP:0004742)	1.96627928
68	Increased serum lactate (HP:0002151)	1.96171722
69	Anencephaly (HP:0002323)	1.95314402
70	Intestinal atresia (HP:0011100)	1.93134479
71	IgG deficiency (HP:0004315)	1.91570000
72	Small hand (HP:0200055)	1.90981110
73	Stenosis of the external auditory canal (HP:0000402)	1.90039087
74	Gait imbalance (HP:0002141)	1.89843125
75	Abnormal drinking behavior (HP:0030082)	1.88545826
76	Polydipsia (HP:0001959)	1.88545826
77	Abnormality of serum amino acid levels (HP:0003112)	1.87633623
78	Abnormality of the duodenum (HP:0002246)	1.84119042
79	Aplastic anemia (HP:0001915)	1.83335873
80	Hypomagnesemia (HP:0002917)	1.83095791
81	Nephrogenic diabetes insipidus (HP:0009806)	1.82999417
82	Postaxial foot polydactyly (HP:0001830)	1.82906054
83	Congenital sensorineural hearing impairment (HP:0008527)	1.81976009
84	Glycosuria (HP:0003076)	1.81670452
85	Abnormality of urine glucose concentration (HP:0011016)	1.81670452
86	CNS demyelination (HP:0007305)	1.81522227
87	Abnormal lung lobation (HP:0002101)	1.80793540
88	Pancytopenia (HP:0001876)	1.79785124
89	Renal Fanconi syndrome (HP:0001994)	1.78660291
90	Genital tract atresia (HP:0001827)	1.77846995
91	Lactic acidosis (HP:0003128)	1.77263036
92	Lethargy (HP:0001254)	1.76001559
93	Hypoproteinemia (HP:0003075)	1.74856162
94	Supernumerary spleens (HP:0009799)	1.74612835
95	Optic nerve hypoplasia (HP:0000609)	1.74004243
96	Ectopic kidney (HP:0000086)	1.72551071
97	Vaginal atresia (HP:0000148)	1.72108631
98	Poikiloderma (HP:0001029)	1.71420357
99	Hypoplasia of the uterus (HP:0000013)	1.70780450
100	Combined immunodeficiency (HP:0005387)	1.70341990

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.26678767
2	WNK3	3.30205563
3	ZAK	2.78824799
4	TXK	2.72652074
5	MAP4K2	2.69386344
6	NUAK1	2.67884721
7	EIF2AK3	2.43712876
8	CDK19	2.21498425
9	TRIM28	2.19395162
10	GRK1	2.05469679
11	CDC7	1.93213151
12	BCKDK	1.89996584
13	MST4	1.87587037
14	TAOK3	1.86270919
15	BMPR1B	1.80397895
16	ADRBK2	1.74364044
17	ACVR1B	1.62622158
18	OXSR1	1.61127739
19	PLK4	1.58841876
20	EIF2AK1	1.56668889
21	STK39	1.54444744
22	BRSK2	1.50368808
23	WEE1	1.47777149
24	PLK3	1.42157366
25	VRK1	1.40703867
26	VRK2	1.40332720
27	MAPK13	1.36664840
28	MKNK2	1.34240308
29	TLK1	1.27436572
30	TNIK	1.27399760
31	WNK4	1.27281044
32	PINK1	1.24967958
33	PDK2	1.23802196
34	PLK2	1.16153767
35	INSRR	1.13449100
36	BUB1	1.11473300
37	NEK1	1.08788976
38	TEC	1.08622312
39	MKNK1	1.07709997
40	PBK	1.07227496
41	PRKD3	1.01547911
42	PLK1	0.98547161
43	STK16	0.94073836
44	KDR	0.91985060
45	MAP3K12	0.90141494
46	FLT3	0.89473655
47	EPHA4	0.88143346
48	MUSK	0.85683470
49	PASK	0.83747984
50	TIE1	0.81416145
51	ATR	0.81170425
52	DYRK2	0.80436510
53	CHEK2	0.79231948
54	NME1	0.77321565
55	EIF2AK2	0.75919612
56	TTK	0.72597286
57	CASK	0.72247601
58	CDK3	0.71069543
59	TGFBR1	0.67215888
60	TNK2	0.66887208
61	TSSK6	0.65715604
62	CCNB1	0.63473577
63	PIK3CG	0.61036182
64	MAP3K4	0.59463147
65	CSNK1G1	0.59336506
66	MAPKAPK3	0.58608198
67	ERBB3	0.57620888
68	PRKCG	0.56325194
69	ATM	0.55477175
70	PRKCE	0.54822756
71	ITK	0.53201780
72	PRKCQ	0.52351933
73	RPS6KA4	0.51901676
74	MAP4K1	0.51155907
75	ADRBK1	0.49758193
76	KIT	0.49181496
77	TRPM7	0.48743268
78	BRSK1	0.46104708
79	STK38L	0.45981426
80	CSNK2A1	0.45747490
81	BMPR2	0.45719190
82	MAPKAPK5	0.45680914
83	ERBB4	0.44808508
84	OBSCN	0.43126245
85	DAPK1	0.42473705
86	NLK	0.42397308
87	CSNK2A2	0.42119488
88	IKBKB	0.41549963
89	MARK3	0.41391600
90	SIK3	0.40115786
91	GRK7	0.39828833
92	PAK3	0.39002713
93	FGFR2	0.38389588
94	LIMK1	0.37671498
95	RPS6KA5	0.37295469
96	PRKACA	0.36794780
97	SRPK1	0.35861128
98	PRKCH	0.35530095
99	PIK3CA	0.35231675
100	PRKCA	0.34853791

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.50811070
2	Homologous recombination_Homo sapiens_hsa03440	2.86898246
3	DNA replication_Homo sapiens_hsa03030	2.46348755
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.42387281
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.40771107
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35598836
7	Mismatch repair_Homo sapiens_hsa03430	2.31432587
8	Ribosome_Homo sapiens_hsa03010	2.30439708
9	RNA polymerase_Homo sapiens_hsa03020	2.29177389
10	Protein export_Homo sapiens_hsa03060	2.25321231
11	Propanoate metabolism_Homo sapiens_hsa00640	2.24358254
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.05764123
13	Parkinsons disease_Homo sapiens_hsa05012	2.02665756
14	One carbon pool by folate_Homo sapiens_hsa00670	1.93393612
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.92936310
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89881238
17	Phototransduction_Homo sapiens_hsa04744	1.89578723
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.88146331
19	RNA degradation_Homo sapiens_hsa03018	1.81580116
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.79972259
21	Butanoate metabolism_Homo sapiens_hsa00650	1.76775431
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.72498467
23	Base excision repair_Homo sapiens_hsa03410	1.70035137
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64397689
25	Pyrimidine metabolism_Homo sapiens_hsa00240	1.63112494
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.59993411
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.56289583
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56281393
29	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.37231160
30	Basal transcription factors_Homo sapiens_hsa03022	1.36590050
31	RNA transport_Homo sapiens_hsa03013	1.35267892
32	Huntingtons disease_Homo sapiens_hsa05016	1.33723986
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.28236076
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.24581315
35	Peroxisome_Homo sapiens_hsa04146	1.23999981
36	Purine metabolism_Homo sapiens_hsa00230	1.19661189
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.17419150
38	Nitrogen metabolism_Homo sapiens_hsa00910	1.17264485
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.13915084
40	Caffeine metabolism_Homo sapiens_hsa00232	1.13213568
41	Olfactory transduction_Homo sapiens_hsa04740	1.11576505
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.09798480
43	Alzheimers disease_Homo sapiens_hsa05010	1.09437334
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.09233134
45	Asthma_Homo sapiens_hsa05310	1.05340449
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03522303
47	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01582821
48	Fatty acid elongation_Homo sapiens_hsa00062	0.96734926
49	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95392708
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94635992
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93858378
52	Fat digestion and absorption_Homo sapiens_hsa04975	0.93779226
53	Glutathione metabolism_Homo sapiens_hsa00480	0.92546402
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92047102
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91363892
56	Retinol metabolism_Homo sapiens_hsa00830	0.90126449
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88565789
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.85749824
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85390998
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82954578
61	Fatty acid degradation_Homo sapiens_hsa00071	0.80327531
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.79814815
63	Allograft rejection_Homo sapiens_hsa05330	0.78559840
64	Spliceosome_Homo sapiens_hsa03040	0.78531690
65	Metabolic pathways_Homo sapiens_hsa01100	0.78488497
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.75817096
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.74804567
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.74148876
69	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.72637665
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72529056
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.71777868
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66166427
73	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65367130
74	Taste transduction_Homo sapiens_hsa04742	0.64533287
75	Nicotine addiction_Homo sapiens_hsa05033	0.61489194
76	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60163451
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59926729
78	Graft-versus-host disease_Homo sapiens_hsa05332	0.59365226
79	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.57269693
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56411136
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56134643
82	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54850937
83	Folate biosynthesis_Homo sapiens_hsa00790	0.54325528
84	Sulfur relay system_Homo sapiens_hsa04122	0.53782410
85	p53 signaling pathway_Homo sapiens_hsa04115	0.53688380
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.51507653
87	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46228186
88	Cell cycle_Homo sapiens_hsa04110	0.44770878
89	Regulation of autophagy_Homo sapiens_hsa04140	0.43795024
90	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.42693311
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42388276
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41985209
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.40318152
94	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38077178
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.32120241
96	Salivary secretion_Homo sapiens_hsa04970	0.30595293
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.29829471
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29610805
99	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.25336491
100	Mineral absorption_Homo sapiens_hsa04978	0.21352522

EEF1B2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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