ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleotide salvage (GO:0043173)	7.38838042
2	viral transcription (GO:0019083)	7.30732375
3	translational termination (GO:0006415)	7.12342916
4	nucleoside salvage (GO:0043174)	6.43972658
5	translational elongation (GO:0006414)	6.42691540
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.30618411
7	pyrimidine nucleoside salvage (GO:0043097)	6.26491831
8	pyrimidine-containing compound salvage (GO:0008655)	6.26491831
9	cotranslational protein targeting to membrane (GO:0006613)	6.18628986
10	protein targeting to ER (GO:0045047)	6.10837901
11	CTP metabolic process (GO:0046036)	5.88860744
12	CTP biosynthetic process (GO:0006241)	5.88860744
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.87909455
14	protein localization to endoplasmic reticulum (GO:0070972)	5.76591466
15	ribosomal small subunit assembly (GO:0000028)	5.63510177
16	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	5.57555747
17	UMP metabolic process (GO:0046049)	5.57555747
18	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	5.57555747
19	UMP biosynthetic process (GO:0006222)	5.57555747
20	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.54052978
21	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.54052978
22	cellular protein complex disassembly (GO:0043624)	5.39745694
23	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	5.37108362
24	maturation of SSU-rRNA (GO:0030490)	5.34383828
25	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	5.21643752
26	ribosomal large subunit biogenesis (GO:0042273)	5.20727640
27	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	5.13745955
28	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.12695452
29	viral life cycle (GO:0019058)	5.10153739
30	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	5.03175354
31	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.88375718
32	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	4.86969163
33	ribosomal small subunit biogenesis (GO:0042274)	4.80963675
34	translational initiation (GO:0006413)	4.59714664
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.55605800
36	ATP synthesis coupled proton transport (GO:0015986)	4.55605800
37	protein complex disassembly (GO:0043241)	4.51569025
38	purine nucleotide salvage (GO:0032261)	4.47006321
39	macromolecular complex disassembly (GO:0032984)	4.33356015
40	translation (GO:0006412)	4.20621401
41	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.18106311
42	protein targeting to membrane (GO:0006612)	4.06496825
43	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.97593875
44	pentose metabolic process (GO:0019321)	3.91635516
45	chaperone-mediated protein transport (GO:0072321)	3.78135552
46	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.78047318
47	protein complex biogenesis (GO:0070271)	3.76414498
48	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.63632882
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61701587
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.60129223
51	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.51538945
52	diterpenoid biosynthetic process (GO:0016102)	3.47318060
53	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.45456905
54	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.43503273
55	cellular metabolic compound salvage (GO:0043094)	3.41757468
56	mRNA catabolic process (GO:0006402)	3.41393678
57	keratinocyte development (GO:0003334)	3.40534525
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.40388309
59	NADH dehydrogenase complex assembly (GO:0010257)	3.40388309
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.40388309
61	protein neddylation (GO:0045116)	3.27198870
62	respiratory electron transport chain (GO:0022904)	3.25669306
63	electron transport chain (GO:0022900)	3.22866290
64	DNA deamination (GO:0045006)	3.18724528
65	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16201366
66	RNA catabolic process (GO:0006401)	3.14522635
67	GTP biosynthetic process (GO:0006183)	3.13755012
68	terpenoid biosynthetic process (GO:0016114)	3.12535156
69	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.10147393
70	purine nucleobase biosynthetic process (GO:0009113)	3.08388906
71	pyrimidine nucleoside biosynthetic process (GO:0046134)	3.08380995
72	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.07699373
73	neutrophil activation involved in immune response (GO:0002283)	3.03336673
74	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99952254
75	nucleoside triphosphate biosynthetic process (GO:0009142)	2.99813300
76	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.95953819
77	regulation of activation of Janus kinase activity (GO:0010533)	2.91076950
78	purine-containing compound salvage (GO:0043101)	2.88585780
79	positive regulation of antigen processing and presentation (GO:0002579)	2.87812167
80	respiratory chain complex IV assembly (GO:0008535)	2.83736295
81	regulation of hypersensitivity (GO:0002883)	2.76477023
82	autophagic vacuole fusion (GO:0000046)	2.76321141
83	cellular component biogenesis (GO:0044085)	2.76301352
84	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.75665811
85	regulation of cellular respiration (GO:0043457)	2.74048830
86	establishment of protein localization to membrane (GO:0090150)	2.72558684
87	pyrimidine-containing compound biosynthetic process (GO:0072528)	2.72420808
88	neutrophil mediated immunity (GO:0002446)	2.71567154
89	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.71514573
90	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.70842463
91	termination of RNA polymerase III transcription (GO:0006386)	2.70842463
92	GPI anchor metabolic process (GO:0006505)	2.68568308
93	hydrogen ion transmembrane transport (GO:1902600)	2.65882787
94	protein targeting (GO:0006605)	2.64337111
95	ribonucleoprotein complex biogenesis (GO:0022613)	2.63954616
96	ATP biosynthetic process (GO:0006754)	2.63637643
97	UTP biosynthetic process (GO:0006228)	2.63259846
98	pyrimidine nucleotide metabolic process (GO:0006220)	2.63137840
99	regulation of glycogen (starch) synthase activity (GO:2000465)	2.62668540
100	DNA ligation (GO:0006266)	2.61008262

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.24997142
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.54044951
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.34352812
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.15078973
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.05073946
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.04044936
7	VDR_22108803_ChIP-Seq_LS180_Human	3.02942429
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.74764714
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.60408423
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.56004962
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42522587
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.34753029
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21367788
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.18932171
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.11469175
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11140179
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.05058027
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.03000977
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.99528153
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.97346480
21	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.96542229
22	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.96521387
23	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93722337
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.92188648
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.82931426
26	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.70368616
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.65769353
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.65654550
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.65267368
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.59315899
31	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.57833377
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.53898366
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51372257
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49670839
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49273888
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43722033
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.43039979
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.39036263
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.37622355
40	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.34183319
41	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.31930524
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31803974
43	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.31690522
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31384233
45	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.30348912
46	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.29313527
47	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.24332248
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23971571
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23971571
50	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.23909011
51	EWS_26573619_Chip-Seq_HEK293_Human	1.20080780
52	GATA3_26560356_Chip-Seq_TH2_Human	1.19973592
53	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.19490476
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19124025
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19124025
56	AR_20517297_ChIP-Seq_VCAP_Human	1.18013870
57	ZNF274_21170338_ChIP-Seq_K562_Hela	1.17690751
58	NCOR_22424771_ChIP-Seq_293T_Human	1.14455290
59	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13708588
60	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.13252918
61	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.13116949
62	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.11679545
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09252246
64	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.06836979
65	P300_19829295_ChIP-Seq_ESCs_Human	1.05531343
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05199866
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04450801
68	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03571716
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02790730
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01861855
71	TAF2_19829295_ChIP-Seq_ESCs_Human	1.01688996
72	FUS_26573619_Chip-Seq_HEK293_Human	1.01586717
73	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01380058
74	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.01227883
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00343333
76	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99849811
77	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99210811
78	XRN2_22483619_ChIP-Seq_HELA_Human	0.98698487
79	RBPJ_21746931_ChIP-Seq_IB4_Human	0.97401080
80	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97320206
81	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.97257736
82	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.97187411
83	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.97176804
84	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.96845518
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96582048
86	CBP_20019798_ChIP-Seq_JUKART_Human	0.96582048
87	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.96132087
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.95962245
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95780733
90	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.95387109
91	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95372158
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.94517018
93	MYC_19829295_ChIP-Seq_ESCs_Human	0.94247199
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.93557906
95	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.93425674
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90910265
97	SOX2_21211035_ChIP-Seq_LN229_Human	0.90881316
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90542348
99	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.89969501
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89268253

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	3.78629053
2	MP0001835_abnormal_antigen_presentation	3.74779723
3	MP0003806_abnormal_nucleotide_metabolis	3.45021994
4	MP0009379_abnormal_foot_pigmentation	3.35923731
5	MP0004147_increased_porphyrin_level	3.25151316
6	MP0006292_abnormal_olfactory_placode	3.24199790
7	MP0005671_abnormal_response_to	2.95486195
8	MP0004145_abnormal_muscle_electrophysio	2.79210349
9	MP0008875_abnormal_xenobiotic_pharmacok	2.75028385
10	MP0005379_endocrine/exocrine_gland_phen	2.52731516
11	MP0003787_abnormal_imprinting	2.48143842
12	MP0008872_abnormal_physiological_respon	2.25658963
13	MP0003724_increased_susceptibility_to	2.17930899
14	MP0004142_abnormal_muscle_tone	2.10113297
15	MP0006072_abnormal_retinal_apoptosis	1.94731851
16	MP0009785_altered_susceptibility_to	1.93622932
17	MP0001873_stomach_inflammation	1.93226300
18	MP0003646_muscle_fatigue	1.84931934
19	MP0003880_abnormal_central_pattern	1.75576484
20	MP0005084_abnormal_gallbladder_morpholo	1.71371625
21	MP0005000_abnormal_immune_tolerance	1.69301045
22	MP0002148_abnormal_hypersensitivity_rea	1.63899923
23	MP0001986_abnormal_taste_sensitivity	1.61067241
24	MP0006082_CNS_inflammation	1.58053002
25	MP0002837_dystrophic_cardiac_calcinosis	1.55345046
26	MP0001529_abnormal_vocalization	1.54260998
27	MP0001800_abnormal_humoral_immune	1.53840799
28	MP0005645_abnormal_hypothalamus_physiol	1.50596809
29	MP0001905_abnormal_dopamine_level	1.46780441
30	MP0001348_abnormal_lacrimal_gland	1.43835590
31	MP0005360_urolithiasis	1.42127737
32	MP0003878_abnormal_ear_physiology	1.40916095
33	MP0005377_hearing/vestibular/ear_phenot	1.40916095
34	MP0009764_decreased_sensitivity_to	1.38050887
35	MP0005083_abnormal_biliary_tract	1.30430722
36	MP0002452_abnormal_antigen_presenting	1.26947189
37	MP0001790_abnormal_immune_system	1.26185223
38	MP0005387_immune_system_phenotype	1.26185223
39	MP0002723_abnormal_immune_serum	1.25980968
40	MP0000372_irregular_coat_pigmentation	1.24487623
41	MP0008877_abnormal_DNA_methylation	1.24326620
42	MP0004885_abnormal_endolymph	1.17735304
43	MP0005551_abnormal_eye_electrophysiolog	1.16941150
44	MP0005025_abnormal_response_to	1.15793229
45	MP0010155_abnormal_intestine_physiology	1.15698513
46	MP0002160_abnormal_reproductive_system	1.14107807
47	MP0005389_reproductive_system_phenotype	1.13163247
48	MP0003195_calcinosis	1.12891842
49	MP0002638_abnormal_pupillary_reflex	1.09721014
50	MP0005646_abnormal_pituitary_gland	1.08857509
51	MP0008058_abnormal_DNA_repair	1.08303977
52	MP0001819_abnormal_immune_cell	1.07078089
53	MP0003011_delayed_dark_adaptation	1.06586944
54	MP0002095_abnormal_skin_pigmentation	1.04758493
55	MP0006276_abnormal_autonomic_nervous	1.03836251
56	MP0003866_abnormal_defecation	1.03124175
57	MP0002272_abnormal_nervous_system	1.01835571
58	MP0002420_abnormal_adaptive_immunity	0.99964704
59	MP0009333_abnormal_splenocyte_physiolog	0.99831101
60	MP0002102_abnormal_ear_morphology	0.98665977
61	MP0002822_catalepsy	0.98261725
62	MP0001756_abnormal_urination	0.97708568
63	MP0006036_abnormal_mitochondrial_physio	0.96794609
64	MP0000538_abnormal_urinary_bladder	0.93026801
65	MP0003186_abnormal_redox_activity	0.92300419
66	MP0001845_abnormal_inflammatory_respons	0.90602885
67	MP0001663_abnormal_digestive_system	0.89570742
68	MP0002234_abnormal_pharynx_morphology	0.89428844
69	MP0005075_abnormal_melanosome_morpholog	0.89232718
70	MP0002876_abnormal_thyroid_physiology	0.88938753
71	MP0005636_abnormal_mineral_homeostasis	0.83580639
72	MP0001501_abnormal_sleep_pattern	0.82438329
73	MP0000685_abnormal_immune_system	0.80167227
74	MP0001440_abnormal_grooming_behavior	0.78429089
75	MP0005085_abnormal_gallbladder_physiolo	0.78298364
76	MP0002938_white_spotting	0.77967186
77	MP0001346_abnormal_lacrimal_gland	0.77771246
78	MP0001970_abnormal_pain_threshold	0.77764209
79	MP0008789_abnormal_olfactory_epithelium	0.77334936
80	MP0002735_abnormal_chemical_nociception	0.76557737
81	MP0009745_abnormal_behavioral_response	0.76033740
82	MP0005423_abnormal_somatic_nervous	0.76008207
83	MP0005253_abnormal_eye_physiology	0.75801628
84	MP0010386_abnormal_urinary_bladder	0.74954700
85	MP0000716_abnormal_immune_system	0.74886748
86	MP0002736_abnormal_nociception_after	0.74044972
87	MP0001293_anophthalmia	0.73708985
88	MP0001664_abnormal_digestion	0.73352389
89	MP0005503_abnormal_tendon_morphology	0.73031568
90	MP0003121_genomic_imprinting	0.71650111
91	MP0000631_abnormal_neuroendocrine_gland	0.71301719
92	MP0009765_abnormal_xenobiotic_induced	0.70787252
93	MP0001919_abnormal_reproductive_system	0.70708504
94	MP0000049_abnormal_middle_ear	0.69772765
95	MP0005332_abnormal_amino_acid	0.68623775
96	MP0008873_increased_physiological_sensi	0.68486558
97	MP0001968_abnormal_touch/_nociception	0.65108770
98	MP0008469_abnormal_protein_level	0.64726321
99	MP0003718_maternal_effect	0.64712550
100	MP0002933_joint_inflammation	0.62290128

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.16676979
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.71664488
3	Mitochondrial inheritance (HP:0001427)	4.44543228
4	Progressive macrocephaly (HP:0004481)	4.26097874
5	Acute encephalopathy (HP:0006846)	4.26005238
6	Hepatocellular necrosis (HP:0001404)	4.00896988
7	Hypoplasia of the pons (HP:0012110)	3.89639346
8	Increased CSF lactate (HP:0002490)	3.89082944
9	Increased hepatocellular lipid droplets (HP:0006565)	3.68564363
10	Abnormality of the pons (HP:0007361)	3.51569381
11	Abnormality of cells of the erythroid lineage (HP:0012130)	3.46571151
12	Macrocytic anemia (HP:0001972)	3.42013974
13	Hepatic necrosis (HP:0002605)	3.40742375
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.37952340
15	Increased intramyocellular lipid droplets (HP:0012240)	3.31585817
16	Lipid accumulation in hepatocytes (HP:0006561)	3.21279109
17	Cerebral edema (HP:0002181)	3.11248429
18	Exertional dyspnea (HP:0002875)	3.10593863
19	Hip dysplasia (HP:0001385)	3.09604689
20	Abnormal hemoglobin (HP:0011902)	3.04882177
21	Abnormal number of erythroid precursors (HP:0012131)	3.00575361
22	Reticulocytopenia (HP:0001896)	2.96436021
23	Optic disc pallor (HP:0000543)	2.95208615
24	Renal Fanconi syndrome (HP:0001994)	2.89657386
25	Opisthotonus (HP:0002179)	2.88448469
26	Pallor (HP:0000980)	2.84889912
27	Poor suck (HP:0002033)	2.82280944
28	3-Methylglutaconic aciduria (HP:0003535)	2.80664173
29	Increased muscle lipid content (HP:0009058)	2.66225981
30	Leukodystrophy (HP:0002415)	2.65228721
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.62393838
32	Difficulty running (HP:0009046)	2.60748597
33	Chronic obstructive pulmonary disease (HP:0006510)	2.57528538
34	Obstructive lung disease (HP:0006536)	2.57528538
35	Constricted visual fields (HP:0001133)	2.53266639
36	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.46427010
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.46427010
38	Congenital, generalized hypertrichosis (HP:0004540)	2.44894754
39	Aplastic anemia (HP:0001915)	2.44228631
40	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.43007346
41	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.37051028
42	Molar tooth sign on MRI (HP:0002419)	2.35341202
43	Abnormality of midbrain morphology (HP:0002418)	2.35341202
44	Elevated erythrocyte sedimentation rate (HP:0003565)	2.33555660
45	Hyperglycinemia (HP:0002154)	2.31707035
46	Abnormality of the prostate (HP:0008775)	2.30762529
47	Pancreatic cysts (HP:0001737)	2.29464920
48	Absent/shortened dynein arms (HP:0200106)	2.27469617
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.27469617
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.26183267
51	Respiratory failure (HP:0002878)	2.25429224
52	Cerebral palsy (HP:0100021)	2.25314495
53	Hypoproteinemia (HP:0003075)	2.24319624
54	Parakeratosis (HP:0001036)	2.23443716
55	Lactic acidosis (HP:0003128)	2.21763905
56	Increased serum lactate (HP:0002151)	2.21214334
57	Progressive microcephaly (HP:0000253)	2.18824310
58	Abnormality of the anterior horn cell (HP:0006802)	2.18675088
59	Degeneration of anterior horn cells (HP:0002398)	2.18675088
60	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.16053353
61	Polydipsia (HP:0001959)	2.14164785
62	Abnormal drinking behavior (HP:0030082)	2.14164785
63	Pancreatic fibrosis (HP:0100732)	2.11926091
64	Hemoptysis (HP:0002105)	2.10373640
65	Abolished electroretinogram (ERG) (HP:0000550)	2.10365354
66	Hip contracture (HP:0003273)	2.09944556
67	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.09396033
68	Myotonia (HP:0002486)	2.03382148
69	Congenital stationary night blindness (HP:0007642)	2.01721364
70	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.01212035
71	Asplenia (HP:0001746)	1.99979469
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.96290421
73	Exercise intolerance (HP:0003546)	1.95564346
74	Attenuation of retinal blood vessels (HP:0007843)	1.94824763
75	Methylmalonic acidemia (HP:0002912)	1.94733082
76	Stenosis of the external auditory canal (HP:0000402)	1.93046447
77	Abnormality of renal resorption (HP:0011038)	1.92344075
78	Dyskinesia (HP:0100660)	1.89187038
79	Tubular atrophy (HP:0000092)	1.86643335
80	Nephronophthisis (HP:0000090)	1.85971073
81	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.84680271
82	Abnormality of the renal medulla (HP:0100957)	1.82849558
83	Impaired smooth pursuit (HP:0007772)	1.82452388
84	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.80619211
85	Respiratory difficulties (HP:0002880)	1.79418521
86	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.78869184
87	Lethargy (HP:0001254)	1.78659290
88	Polyuria (HP:0000103)	1.78613562
89	Type 2 muscle fiber atrophy (HP:0003554)	1.77039696
90	Concave nail (HP:0001598)	1.76640925
91	CNS demyelination (HP:0007305)	1.76281984
92	Glycosuria (HP:0003076)	1.76042067
93	Abnormality of urine glucose concentration (HP:0011016)	1.76042067
94	Achilles tendon contracture (HP:0001771)	1.75941148
95	Restlessness (HP:0000711)	1.74069922
96	Hypomagnesemia (HP:0002917)	1.72990707
97	Genetic anticipation (HP:0003743)	1.70324879
98	Hyperphosphaturia (HP:0003109)	1.67740184
99	Thrombocytosis (HP:0001894)	1.67197247
100	IgG deficiency (HP:0004315)	1.66241099

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.51318341
2	TLK1	2.83822300
3	LIMK1	2.75406025
4	TXK	2.58722463
5	MAP4K2	2.57630535
6	WNK4	2.40713962
7	TAOK3	2.38875278
8	MAP4K1	2.38493322
9	BCKDK	2.36810619
10	BMPR2	2.18979524
11	MAP3K12	2.14072080
12	ZAK	2.12456130
13	TRPM7	2.11437336
14	NUAK1	1.97021545
15	OXSR1	1.92745170
16	CSF1R	1.84876211
17	MYLK	1.84765796
18	GRK1	1.74106969
19	KIT	1.68887821
20	ADRBK2	1.67272746
21	NME2	1.50287729
22	TIE1	1.49557083
23	IKBKB	1.47370087
24	ILK	1.39363003
25	FLT3	1.34970761
26	KDR	1.33157138
27	FRK	1.31811781
28	TEC	1.23140039
29	STK16	1.19615470
30	RPS6KA5	1.15553713
31	DYRK2	1.14560713
32	STK39	1.14487877
33	LYN	1.10427555
34	INSRR	1.09461224
35	SCYL2	1.09414786
36	BMPR1B	1.05971324
37	ITK	1.05560144
38	WNK3	1.01991146
39	IKBKE	1.00246907
40	SYK	0.99687835
41	FES	0.95658162
42	NLK	0.95363586
43	PRKCQ	0.94595314
44	PASK	0.94325636
45	CSNK2A2	0.94280741
46	MAP3K13	0.93761770
47	CSNK1G1	0.91910673
48	LCK	0.91415741
49	OBSCN	0.89612921
50	PRKCG	0.89172353
51	ABL2	0.84036735
52	ADRBK1	0.80695989
53	MINK1	0.79736043
54	MST4	0.79627434
55	NEK1	0.77553639
56	CSNK2A1	0.76799912
57	LRRK2	0.75079113
58	JAK3	0.73775849
59	PINK1	0.72510726
60	DAPK3	0.71736451
61	MAPK13	0.68366415
62	TGFBR1	0.67081890
63	BTK	0.66618486
64	PKN1	0.64985394
65	PLK4	0.64979765
66	MATK	0.62299587
67	VRK1	0.62296178
68	PIK3CA	0.61264004
69	IGF1R	0.59163202
70	RPS6KA4	0.57153566
71	GRK7	0.53795725
72	PRKCA	0.53673637
73	PRKACA	0.53543100
74	MAP2K6	0.52949663
75	PAK1	0.52940715
76	CSNK1A1	0.51563704
77	PRKCE	0.51496506
78	PDK1	0.51271049
79	CAMK2D	0.50313813
80	MUSK	0.50307347
81	TESK1	0.49527034
82	NTRK2	0.49312655
83	MARK3	0.45807858
84	PRKCD	0.45634578
85	ABL1	0.44634520
86	RPS6KA6	0.43725160
87	DAPK1	0.43393324
88	EIF2AK3	0.43367931
89	RPS6KB2	0.43000932
90	EGFR	0.41700484
91	PIK3CG	0.39265496
92	CSNK1G3	0.38004662
93	ZAP70	0.37301330
94	PRKG1	0.36086280
95	MAP3K14	0.35886110
96	CAMK2A	0.32386125
97	RPS6KL1	0.31743019
98	RPS6KC1	0.31743019
99	AURKB	0.30756182
100	PIM1	0.30285996

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.85225626
2	Asthma_Homo sapiens_hsa05310	4.76741237
3	Allograft rejection_Homo sapiens_hsa05330	3.99424203
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.54155115
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.44413993
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.39956210
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.19053180
8	Oxidative phosphorylation_Homo sapiens_hsa00190	3.08682250
9	Sulfur relay system_Homo sapiens_hsa04122	2.84386168
10	Parkinsons disease_Homo sapiens_hsa05012	2.50001634
11	Protein export_Homo sapiens_hsa03060	2.19561704
12	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.12913454
13	Proteasome_Homo sapiens_hsa03050	2.07095073
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.91149874
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.86999427
16	Viral myocarditis_Homo sapiens_hsa05416	1.83075374
17	Rheumatoid arthritis_Homo sapiens_hsa05323	1.72566699
18	RNA polymerase_Homo sapiens_hsa03020	1.69660538
19	Alzheimers disease_Homo sapiens_hsa05010	1.64437486
20	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.64048110
21	Huntingtons disease_Homo sapiens_hsa05016	1.58154487
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54527375
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.52807820
24	Leishmaniasis_Homo sapiens_hsa05140	1.48354464
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39274002
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35067886
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.31676218
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.25514179
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.21427690
30	RNA degradation_Homo sapiens_hsa03018	1.09923051
31	DNA replication_Homo sapiens_hsa03030	1.03857763
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.00264836
33	Phototransduction_Homo sapiens_hsa04744	0.93329800
34	Tryptophan metabolism_Homo sapiens_hsa00380	0.90577933
35	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.88856235
36	Pentose phosphate pathway_Homo sapiens_hsa00030	0.84679068
37	Non-homologous end-joining_Homo sapiens_hsa03450	0.83362482
38	Butanoate metabolism_Homo sapiens_hsa00650	0.79217461
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.74600405
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.71490600
41	Influenza A_Homo sapiens_hsa05164	0.70324148
42	Fat digestion and absorption_Homo sapiens_hsa04975	0.69470269
43	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68893815
44	Caffeine metabolism_Homo sapiens_hsa00232	0.68315920
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65223232
46	One carbon pool by folate_Homo sapiens_hsa00670	0.65005113
47	Purine metabolism_Homo sapiens_hsa00230	0.64802558
48	Homologous recombination_Homo sapiens_hsa03440	0.61123374
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.60597918
50	Peroxisome_Homo sapiens_hsa04146	0.58412871
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57547723
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57406453
53	Olfactory transduction_Homo sapiens_hsa04740	0.54313034
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54073109
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53990525
56	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53455892
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.52085002
58	Fatty acid elongation_Homo sapiens_hsa00062	0.52017057
59	Propanoate metabolism_Homo sapiens_hsa00640	0.51758187
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51688747
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49881827
62	Phagosome_Homo sapiens_hsa04145	0.49811169
63	Nicotine addiction_Homo sapiens_hsa05033	0.48439708
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.48089851
65	Tuberculosis_Homo sapiens_hsa05152	0.47211176
66	Retinol metabolism_Homo sapiens_hsa00830	0.47139269
67	Metabolic pathways_Homo sapiens_hsa01100	0.46531302
68	Base excision repair_Homo sapiens_hsa03410	0.45861178
69	African trypanosomiasis_Homo sapiens_hsa05143	0.45776872
70	Sulfur metabolism_Homo sapiens_hsa00920	0.45402190
71	Regulation of autophagy_Homo sapiens_hsa04140	0.43654496
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43177606
73	Measles_Homo sapiens_hsa05162	0.43165659
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42619734
75	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.42095601
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.41677132
77	Herpes simplex infection_Homo sapiens_hsa05168	0.40762151
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40101975
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.39144812
80	Toxoplasmosis_Homo sapiens_hsa05145	0.38485151
81	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.37788428
82	Legionellosis_Homo sapiens_hsa05134	0.36639600
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.35171527
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.33529458
85	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32706022
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.31195987
87	RNA transport_Homo sapiens_hsa03013	0.29935121
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28551354
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27610150
90	Malaria_Homo sapiens_hsa05144	0.27437541
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26860282
92	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26553442
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24631373
94	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.24540807
95	Basal transcription factors_Homo sapiens_hsa03022	0.24479585
96	Glutathione metabolism_Homo sapiens_hsa00480	0.23237628
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.22617324
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22108490
99	Taste transduction_Homo sapiens_hsa04742	0.18922773
100	Spliceosome_Homo sapiens_hsa03040	0.17960910

EEF1B2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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