EEF1B2P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98887670
2ATP synthesis coupled proton transport (GO:0015986)4.86946467
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86946467
4signal peptide processing (GO:0006465)4.83992559
5behavioral response to nicotine (GO:0035095)4.61818960
6DNA deamination (GO:0045006)4.48341978
7platelet dense granule organization (GO:0060155)4.32613346
8response to pheromone (GO:0019236)3.83200330
9establishment of protein localization to mitochondrial membrane (GO:0090151)3.81745051
10protein complex biogenesis (GO:0070271)3.76115129
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.69818988
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.58503293
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57634251
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57634251
15GTP biosynthetic process (GO:0006183)3.55664235
16maturation of SSU-rRNA (GO:0030490)3.53269854
17L-fucose catabolic process (GO:0042355)3.42435611
18fucose catabolic process (GO:0019317)3.42435611
19L-fucose metabolic process (GO:0042354)3.42435611
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42206648
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.42206648
22NADH dehydrogenase complex assembly (GO:0010257)3.42206648
23mitochondrial respiratory chain complex assembly (GO:0033108)3.42142911
24somite development (GO:0061053)3.35875395
25nucleoside transmembrane transport (GO:1901642)3.30708872
26protein prenylation (GO:0018342)3.30581738
27prenylation (GO:0097354)3.30581738
28viral transcription (GO:0019083)3.28485395
29protein neddylation (GO:0045116)3.27333636
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22174542
31striatum development (GO:0021756)3.17410183
32translational termination (GO:0006415)3.15766905
33ribosomal small subunit assembly (GO:0000028)3.13937587
34negative regulation of heart rate (GO:0010459)3.06448440
35GPI anchor metabolic process (GO:0006505)3.02128939
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.00424540
37protein targeting to ER (GO:0045047)2.99238374
38indolalkylamine metabolic process (GO:0006586)2.99188932
39negative regulation of telomere maintenance (GO:0032205)2.98107451
40kidney morphogenesis (GO:0060993)2.96812927
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96788697
42chaperone-mediated protein transport (GO:0072321)2.96488771
43purine nucleoside triphosphate biosynthetic process (GO:0009145)2.94708812
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93090899
45dopamine transport (GO:0015872)2.92878951
46electron transport chain (GO:0022900)2.91552304
47respiratory electron transport chain (GO:0022904)2.91301422
48intraciliary transport (GO:0042073)2.90846909
49cotranslational protein targeting to membrane (GO:0006613)2.90246443
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89194243
51DNA ligation (GO:0006266)2.88735585
52termination of RNA polymerase III transcription (GO:0006386)2.87472999
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.87472999
54piRNA metabolic process (GO:0034587)2.86310934
55protein polyglutamylation (GO:0018095)2.86267468
56UTP biosynthetic process (GO:0006228)2.86077251
57negative regulation of membrane potential (GO:0045837)2.85082120
58axonemal dynein complex assembly (GO:0070286)2.81036392
59establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80879546
60protein localization to endoplasmic reticulum (GO:0070972)2.78660887
61translational elongation (GO:0006414)2.76174005
62cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.76158334
63GPI anchor biosynthetic process (GO:0006506)2.75170464
64reflex (GO:0060004)2.75076803
65positive regulation of prostaglandin secretion (GO:0032308)2.74844231
66epithelial cilium movement (GO:0003351)2.74483724
67ATP biosynthetic process (GO:0006754)2.73330898
68cytochrome complex assembly (GO:0017004)2.70522019
69dentate gyrus development (GO:0021542)2.70436582
70aldehyde catabolic process (GO:0046185)2.70037917
71hydrogen ion transmembrane transport (GO:1902600)2.69296219
72rRNA modification (GO:0000154)2.67434455
73valine metabolic process (GO:0006573)2.67428554
74UTP metabolic process (GO:0046051)2.67339773
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66053198
76proton transport (GO:0015992)2.65982429
77positive regulation of protein homodimerization activity (GO:0090073)2.64481455
78respiratory chain complex IV assembly (GO:0008535)2.64167731
79detection of light stimulus involved in visual perception (GO:0050908)2.63987294
80detection of light stimulus involved in sensory perception (GO:0050962)2.63987294
81kynurenine metabolic process (GO:0070189)2.63778087
82negative regulation of mast cell activation (GO:0033004)2.63186915
83indole-containing compound catabolic process (GO:0042436)2.60238879
84indolalkylamine catabolic process (GO:0046218)2.60238879
85tryptophan catabolic process (GO:0006569)2.60238879
86hydrogen transport (GO:0006818)2.58141063
87axoneme assembly (GO:0035082)2.55741383
88positive regulation of fatty acid transport (GO:2000193)2.53492650
89preassembly of GPI anchor in ER membrane (GO:0016254)2.52185579
90regulation of action potential (GO:0098900)2.50376660
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.49540959
92substrate-independent telencephalic tangential migration (GO:0021826)2.48482746
93substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.48482746
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.46915229
95multicellular organism reproduction (GO:0032504)2.45909476
96viral life cycle (GO:0019058)2.44261896
97centriole replication (GO:0007099)2.44159301
98protein localization to cilium (GO:0061512)2.43704570
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.43587577
100ribosomal small subunit biogenesis (GO:0042274)2.43444500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse4.07449485
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.30618472
3ZNF274_21170338_ChIP-Seq_K562_Hela3.25671121
4VDR_22108803_ChIP-Seq_LS180_Human3.25243719
5EZH2_22144423_ChIP-Seq_EOC_Human3.04414746
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.65651111
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58837022
8TAF15_26573619_Chip-Seq_HEK293_Human2.24270629
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.24048978
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19660505
11GBX2_23144817_ChIP-Seq_PC3_Human2.11178029
12EWS_26573619_Chip-Seq_HEK293_Human2.11099580
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11001256
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06004114
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04655916
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.04457050
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99330860
18ER_23166858_ChIP-Seq_MCF-7_Human1.92584749
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92261223
20FUS_26573619_Chip-Seq_HEK293_Human1.90977548
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86975550
22P300_19829295_ChIP-Seq_ESCs_Human1.85444426
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83737387
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80358367
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68038769
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67723663
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.67493310
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64507192
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58071697
30SOX2_19829295_ChIP-Seq_ESCs_Human1.57721003
31NANOG_19829295_ChIP-Seq_ESCs_Human1.57721003
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57643577
33CBP_20019798_ChIP-Seq_JUKART_Human1.53404619
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53404619
35VDR_23849224_ChIP-Seq_CD4+_Human1.52283776
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.51538619
37IRF1_19129219_ChIP-ChIP_H3396_Human1.50952704
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.50225368
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49783941
40AR_21572438_ChIP-Seq_LNCaP_Human1.49196924
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48216995
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46401693
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.46401693
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45327943
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40062447
46MYC_18940864_ChIP-ChIP_HL60_Human1.39232522
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37311638
48ELK1_19687146_ChIP-ChIP_HELA_Human1.36598035
49TCF4_22108803_ChIP-Seq_LS180_Human1.35364010
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34639169
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32903491
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32283792
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32277725
54AR_25329375_ChIP-Seq_VCAP_Human1.32220795
55EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32121143
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30438675
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.30095300
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.29212023
59TP53_22573176_ChIP-Seq_HFKS_Human1.27930829
60NANOG_20526341_ChIP-Seq_ESCs_Human1.27432789
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26314530
62BCAT_22108803_ChIP-Seq_LS180_Human1.24414796
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22591512
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.20093586
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19897823
66FOXH1_21741376_ChIP-Seq_EPCs_Human1.17791752
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.16860812
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16656311
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.15357989
70RNF2_27304074_Chip-Seq_NSC_Mouse1.14941759
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14888156
72SMAD4_21799915_ChIP-Seq_A2780_Human1.14828092
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13661886
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13369458
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10984779
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.10923970
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.08725560
78AR_20517297_ChIP-Seq_VCAP_Human1.08680684
79GATA3_26560356_Chip-Seq_TH2_Human1.08107005
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06554771
81STAT3_23295773_ChIP-Seq_U87_Human1.04895645
82IGF1R_20145208_ChIP-Seq_DFB_Human1.03992012
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03881284
84AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02578517
85REST_21632747_ChIP-Seq_MESCs_Mouse1.02433024
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01450994
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.01329267
88PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01178979
89EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00841060
90TCF4_23295773_ChIP-Seq_U87_Human0.99629901
91EZH2_27304074_Chip-Seq_ESCs_Mouse0.99072092
92RUNX2_22187159_ChIP-Seq_PCA_Human0.97789896
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97746215
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97705430
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97705430
96ERA_21632823_ChIP-Seq_H3396_Human0.96490860
97NCOR_22424771_ChIP-Seq_293T_Human0.96301377
98BP1_19119308_ChIP-ChIP_Hs578T_Human0.96172647
99PHF8_20622853_ChIP-Seq_HELA_Human0.96052693
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94737924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.47090523
2MP0003880_abnormal_central_pattern3.60568007
3MP0010030_abnormal_orbit_morphology3.60527381
4MP0003646_muscle_fatigue3.08555100
5MP0002102_abnormal_ear_morphology2.95536284
6MP0004145_abnormal_muscle_electrophysio2.50665749
7MP0002653_abnormal_ependyma_morphology2.33489241
8MP0006072_abnormal_retinal_apoptosis2.10061567
9MP0005551_abnormal_eye_electrophysiolog2.07914936
10MP0008872_abnormal_physiological_respon1.95305384
11MP0005248_abnormal_Harderian_gland1.92762194
12MP0005671_abnormal_response_to1.87612176
13MP0005084_abnormal_gallbladder_morpholo1.86903022
14MP0001835_abnormal_antigen_presentation1.83332346
15MP0006276_abnormal_autonomic_nervous1.82241032
16MP0008877_abnormal_DNA_methylation1.74616453
17MP0006292_abnormal_olfactory_placode1.68548807
18MP0002638_abnormal_pupillary_reflex1.65910603
19MP0008995_early_reproductive_senescence1.64879025
20MP0005253_abnormal_eye_physiology1.62084966
21MP0004142_abnormal_muscle_tone1.61507621
22MP0002736_abnormal_nociception_after1.52169348
23MP0000685_abnormal_immune_system1.50952290
24MP0004742_abnormal_vestibular_system1.46212867
25MP0005645_abnormal_hypothalamus_physiol1.46203054
26MP0002282_abnormal_trachea_morphology1.42786111
27MP0000569_abnormal_digit_pigmentation1.41594501
28MP0002095_abnormal_skin_pigmentation1.40202908
29MP0000427_abnormal_hair_cycle1.40028106
30MP0004147_increased_porphyrin_level1.39693627
31MP0002234_abnormal_pharynx_morphology1.38406838
32MP0004885_abnormal_endolymph1.38159763
33MP0009745_abnormal_behavioral_response1.28608153
34MP0001968_abnormal_touch/_nociception1.27321694
35MP0008875_abnormal_xenobiotic_pharmacok1.24834272
36MP0000778_abnormal_nervous_system1.22004773
37MP0002272_abnormal_nervous_system1.21192887
38MP0005195_abnormal_posterior_eye1.19760359
39MP0000372_irregular_coat_pigmentation1.18502743
40MP0005377_hearing/vestibular/ear_phenot1.17793058
41MP0003878_abnormal_ear_physiology1.17793058
42MP0005646_abnormal_pituitary_gland1.16094888
43MP0001986_abnormal_taste_sensitivity1.13054709
44MP0002233_abnormal_nose_morphology1.12968589
45MP0005389_reproductive_system_phenotype1.12874756
46MP0005379_endocrine/exocrine_gland_phen1.12201481
47MP0001919_abnormal_reproductive_system1.11748367
48MP0001293_anophthalmia1.10696200
49MP0005075_abnormal_melanosome_morpholog1.09326027
50MP0000534_abnormal_ureter_morphology1.09107127
51MP0001486_abnormal_startle_reflex1.07876514
52MP0001984_abnormal_olfaction1.07798923
53MP0009046_muscle_twitch1.07663079
54MP0001800_abnormal_humoral_immune1.06896824
55MP0003011_delayed_dark_adaptation1.06471948
56MP0002752_abnormal_somatic_nervous1.05106231
57MP0001286_abnormal_eye_development1.04775027
58MP0008775_abnormal_heart_ventricle1.04354153
59MP0005174_abnormal_tail_pigmentation1.03118046
60MP0005387_immune_system_phenotype1.02325286
61MP0001790_abnormal_immune_system1.02325286
62MP0001485_abnormal_pinna_reflex1.00965693
63MP0002876_abnormal_thyroid_physiology0.98755290
64MP0002184_abnormal_innervation0.98297393
65MP0001970_abnormal_pain_threshold0.97976968
66MP0002751_abnormal_autonomic_nervous0.96858370
67MP0002938_white_spotting0.95527075
68MP0003186_abnormal_redox_activity0.95443972
69MP0006054_spinal_hemorrhage0.93970547
70MP0009764_decreased_sensitivity_to0.93917750
71MP0000613_abnormal_salivary_gland0.92023532
72MP0005410_abnormal_fertilization0.91185695
73MP0003787_abnormal_imprinting0.91125154
74MP0002837_dystrophic_cardiac_calcinosis0.89498495
75MP0005423_abnormal_somatic_nervous0.89139970
76MP0001905_abnormal_dopamine_level0.89131873
77MP0000026_abnormal_inner_ear0.89091888
78MP0002229_neurodegeneration0.88902230
79MP0002160_abnormal_reproductive_system0.88701562
80MP0008789_abnormal_olfactory_epithelium0.87050725
81MP0000230_abnormal_systemic_arterial0.85543337
82MP0002163_abnormal_gland_morphology0.84955451
83MP0005171_absent_coat_pigmentation0.84022593
84MP0002210_abnormal_sex_determination0.83716140
85MP0003718_maternal_effect0.82827546
86MP0000647_abnormal_sebaceous_gland0.82688765
87MP0002557_abnormal_social/conspecific_i0.81758775
88MP0001529_abnormal_vocalization0.81267113
89MP0002067_abnormal_sensory_capabilities0.80299086
90MP0005391_vision/eye_phenotype0.79995049
91MP0005197_abnormal_uvea_morphology0.79481810
92MP0001440_abnormal_grooming_behavior0.77657343
93MP0003122_maternal_imprinting0.77538671
94MP0001929_abnormal_gametogenesis0.77095924
95MP0002572_abnormal_emotion/affect_behav0.76055957
96MP0001501_abnormal_sleep_pattern0.76019102
97MP0003195_calcinosis0.74602591
98MP0001663_abnormal_digestive_system0.72499334
99MP0003698_abnormal_male_reproductive0.72323793
100MP0004133_heterotaxia0.71402938

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)4.61300500
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.24989349
3Absent/shortened dynein arms (HP:0200106)4.24989349
4Abnormality of midbrain morphology (HP:0002418)4.00185335
5Molar tooth sign on MRI (HP:0002419)4.00185335
6Abnormal rod and cone electroretinograms (HP:0008323)3.99919600
7Pancreatic cysts (HP:0001737)3.90958995
8Pancreatic fibrosis (HP:0100732)3.88130656
9Attenuation of retinal blood vessels (HP:0007843)3.65833724
10True hermaphroditism (HP:0010459)3.55648695
11Pendular nystagmus (HP:0012043)3.53868833
12Abnormal pancreas size (HP:0012094)3.46646084
13Decreased central vision (HP:0007663)3.42189635
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.32647331
153-Methylglutaconic aciduria (HP:0003535)3.28054867
16Abnormal ciliary motility (HP:0012262)2.96640643
17Abnormal respiratory motile cilium morphology (HP:0005938)2.96093064
18Abnormal respiratory epithelium morphology (HP:0012253)2.96093064
19Nephronophthisis (HP:0000090)2.95275473
20Acute necrotizing encephalopathy (HP:0006965)2.94627873
21Congenital stationary night blindness (HP:0007642)2.93099944
22Medial flaring of the eyebrow (HP:0010747)2.86819783
23Reticulocytopenia (HP:0001896)2.84169610
24Abnormal respiratory motile cilium physiology (HP:0012261)2.82053688
25Anophthalmia (HP:0000528)2.80800641
26Annular pancreas (HP:0001734)2.77622169
27Mitochondrial inheritance (HP:0001427)2.71432132
28Abnormality of the renal cortex (HP:0011035)2.69220586
29Abnormality of the renal medulla (HP:0100957)2.69181926
30Acute encephalopathy (HP:0006846)2.65531388
31Polyuria (HP:0000103)2.63281128
32Abnormal lung lobation (HP:0002101)2.63231340
33Anencephaly (HP:0002323)2.58713041
34Lipid accumulation in hepatocytes (HP:0006561)2.58362377
35Increased CSF lactate (HP:0002490)2.57477607
36Increased hepatocellular lipid droplets (HP:0006565)2.48780037
37Abnormal mitochondria in muscle tissue (HP:0008316)2.46767666
38Metabolic alkalosis (HP:0200114)2.43058977
39Optic disc pallor (HP:0000543)2.42457306
40Abolished electroretinogram (ERG) (HP:0000550)2.41640352
41Sclerocornea (HP:0000647)2.38186399
42Cystic liver disease (HP:0006706)2.37264977
43Elevated erythrocyte sedimentation rate (HP:0003565)2.34740800
44Progressive macrocephaly (HP:0004481)2.33816532
45Type 2 muscle fiber atrophy (HP:0003554)2.29347056
46Supernumerary spleens (HP:0009799)2.26791021
47Hypokalemic alkalosis (HP:0001949)2.24131961
48IgG deficiency (HP:0004315)2.23799253
49Abnormal urine output (HP:0012590)2.23148638
50Abnormality of renal resorption (HP:0011038)2.20663508
51Increased corneal curvature (HP:0100692)2.19960214
52Keratoconus (HP:0000563)2.19960214
53Hepatocellular necrosis (HP:0001404)2.19577093
54Postaxial foot polydactyly (HP:0001830)2.19413338
55Constricted visual fields (HP:0001133)2.15752605
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13424222
57Abnormality of alanine metabolism (HP:0010916)2.13424222
58Hyperalaninemia (HP:0003348)2.13424222
59Hyperglycinemia (HP:0002154)2.13094006
60Hypoproteinemia (HP:0003075)2.11442361
61Recurrent sinusitis (HP:0011108)2.09765313
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.07933088
63Cerebral palsy (HP:0100021)2.05705831
64Type II lissencephaly (HP:0007260)2.04158815
65Thyroiditis (HP:0100646)2.02446086
66Abnormality of renal excretion (HP:0011036)2.00947534
67Abnormality of cells of the erythroid lineage (HP:0012130)2.00672510
68Muscle fiber atrophy (HP:0100295)1.99205295
69Tubular atrophy (HP:0000092)1.99063712
70Bony spicule pigmentary retinopathy (HP:0007737)1.98794406
71Severe combined immunodeficiency (HP:0004430)1.96742184
72Gait imbalance (HP:0002141)1.93206498
73Hyperglycinuria (HP:0003108)1.91157611
74Increased circulating renin level (HP:0000848)1.88838956
75Alkalosis (HP:0001948)1.87718914
76Bicornuate uterus (HP:0000813)1.86735429
77Congenital, generalized hypertrichosis (HP:0004540)1.86468199
78Renal salt wasting (HP:0000127)1.82381603
79Limb hypertonia (HP:0002509)1.82200182
80Hepatic necrosis (HP:0002605)1.82159839
81Bile duct proliferation (HP:0001408)1.81935880
82Abnormal biliary tract physiology (HP:0012439)1.81935880
83Occipital encephalocele (HP:0002085)1.81578065
84Disinhibition (HP:0000734)1.79238242
85Abnormal drinking behavior (HP:0030082)1.78689190
86Polydipsia (HP:0001959)1.78689190
87Renal Fanconi syndrome (HP:0001994)1.78084372
88Optic nerve hypoplasia (HP:0000609)1.76896375
89Exertional dyspnea (HP:0002875)1.76395028
90Intestinal atresia (HP:0011100)1.74849082
91Congenital primary aphakia (HP:0007707)1.74822317
92Congenital hepatic fibrosis (HP:0002612)1.74796030
93Pallor (HP:0000980)1.74126560
94Absent speech (HP:0001344)1.73151417
95Increased serum lactate (HP:0002151)1.72949608
96Rhinitis (HP:0012384)1.72259190
97Abnormal number of erythroid precursors (HP:0012131)1.70091954
98Lissencephaly (HP:0001339)1.68275184
99Hypomagnesemia (HP:0002917)1.68116580
100Preaxial hand polydactyly (HP:0001177)1.67689106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.69201983
2FRK2.79254437
3GRK12.43080632
4PINK12.37849921
5WNK32.34006604
6ADRBK22.30450914
7MAP3K42.23385846
8MAP3K122.20732805
9ZAK2.18307482
10MAP4K22.15379877
11WNK42.12789774
12INSRR2.05781723
13MAP2K72.02316457
14BMPR21.83781196
15CDK191.82831905
16TIE11.79776973
17TXK1.76599605
18ACVR1B1.65655463
19NUAK11.60171071
20GRK61.59298400
21MAPK131.53122179
22BMPR1B1.47554415
23TNIK1.46258433
24STK161.44648298
25NME11.37051817
26CAMKK21.35040056
27OXSR11.34654293
28STK391.29943896
29PLK41.27958304
30STK38L1.23896157
31DYRK21.21974214
32KDR1.19298942
33CASK1.12326416
34DAPK21.08913518
35PIK3CG1.07422941
36PLK21.06701629
37MYLK1.04592021
38TEC1.02891655
39MAP3K61.01234564
40VRK20.96056614
41VRK10.91425032
42MARK10.89207670
43FES0.88226097
44MAP3K110.85031393
45CCNB10.84392101
46ILK0.84265136
47KIT0.83962995
48PKN10.83482711
49PAK30.82308661
50PLK30.80976794
51EPHA40.78339157
52PRKCQ0.77247137
53TGFBR10.74061094
54ERBB30.73667865
55OBSCN0.73167663
56PIK3CA0.72307990
57PASK0.70647087
58ERBB20.70398913
59GRK70.70121008
60BRSK20.70101500
61PTK2B0.69808588
62SYK0.68317778
63IKBKB0.67469499
64BTK0.67382545
65CAMK10.66068973
66CDK80.65290941
67TAOK30.64715884
68ADRBK10.64231713
69NLK0.60275425
70CSNK1G20.59806370
71PRKACA0.59174524
72PHKG20.59056048
73PHKG10.59056048
74DAPK30.58161667
75NTRK30.57762712
76NME20.57501974
77PRKCG0.56986818
78MARK30.54323527
79TYRO30.52217721
80RIPK40.52083111
81RPS6KA50.52027977
82MST40.51399842
83MATK0.50885911
84MAPK150.50865477
85TSSK60.50445711
86TRIM280.49540005
87MKNK20.48882069
88BCKDK0.48825206
89AURKB0.48767336
90TRPM70.48476285
91CSNK2A20.47780174
92WEE10.47308110
93LCK0.45075758
94IGF1R0.44919530
95ROCK10.42541160
96CSNK2A10.42386526
97ITK0.41300941
98STK240.40824104
99CAMKK10.40676634
100PRKCA0.40125741

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.05725513
2Oxidative phosphorylation_Homo sapiens_hsa001903.24300825
3Autoimmune thyroid disease_Homo sapiens_hsa053203.18462583
4Allograft rejection_Homo sapiens_hsa053303.17144767
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.05465651
6Ribosome_Homo sapiens_hsa030102.96153374
7Graft-versus-host disease_Homo sapiens_hsa053322.80510123
8Protein export_Homo sapiens_hsa030602.75713914
9Parkinsons disease_Homo sapiens_hsa050122.71053759
10Type I diabetes mellitus_Homo sapiens_hsa049402.48459117
11Proteasome_Homo sapiens_hsa030502.35521234
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23239586
13RNA polymerase_Homo sapiens_hsa030201.90224733
14Antigen processing and presentation_Homo sapiens_hsa046121.81687268
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.81355129
16Nitrogen metabolism_Homo sapiens_hsa009101.79319046
17Alzheimers disease_Homo sapiens_hsa050101.75792155
18Huntingtons disease_Homo sapiens_hsa050161.75604197
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73302860
20Phototransduction_Homo sapiens_hsa047441.73076534
21Cardiac muscle contraction_Homo sapiens_hsa042601.58055917
22Linoleic acid metabolism_Homo sapiens_hsa005911.57298038
23Regulation of autophagy_Homo sapiens_hsa041401.56579596
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56276539
25Primary immunodeficiency_Homo sapiens_hsa053401.49416540
26Collecting duct acid secretion_Homo sapiens_hsa049661.47334164
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42169128
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39385378
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36989929
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33053563
31Rheumatoid arthritis_Homo sapiens_hsa053231.31108193
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27858042
33Homologous recombination_Homo sapiens_hsa034401.27124614
34Caffeine metabolism_Homo sapiens_hsa002321.26986106
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13836452
36RNA degradation_Homo sapiens_hsa030181.13414270
37Tryptophan metabolism_Homo sapiens_hsa003801.13111701
38Olfactory transduction_Homo sapiens_hsa047401.11040778
39Viral myocarditis_Homo sapiens_hsa054161.04356318
40Staphylococcus aureus infection_Homo sapiens_hsa051501.03345511
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99099539
42Peroxisome_Homo sapiens_hsa041460.92496398
43One carbon pool by folate_Homo sapiens_hsa006700.90237469
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88852495
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.88764092
46Nicotine addiction_Homo sapiens_hsa050330.85573824
47Fanconi anemia pathway_Homo sapiens_hsa034600.82966722
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77761341
49Systemic lupus erythematosus_Homo sapiens_hsa053220.75249732
50Chemical carcinogenesis_Homo sapiens_hsa052040.74038408
51Taste transduction_Homo sapiens_hsa047420.73937197
52Propanoate metabolism_Homo sapiens_hsa006400.72762531
53Ether lipid metabolism_Homo sapiens_hsa005650.70331944
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70320525
55ABC transporters_Homo sapiens_hsa020100.68628935
56Non-homologous end-joining_Homo sapiens_hsa034500.64665983
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62979147
58Purine metabolism_Homo sapiens_hsa002300.61839236
59Butanoate metabolism_Homo sapiens_hsa006500.61039379
60RNA transport_Homo sapiens_hsa030130.59576501
61Morphine addiction_Homo sapiens_hsa050320.56970548
62Ovarian steroidogenesis_Homo sapiens_hsa049130.55922979
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54537051
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54118793
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53821929
66Basal transcription factors_Homo sapiens_hsa030220.51409072
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50154576
68Pyrimidine metabolism_Homo sapiens_hsa002400.49664127
69Hematopoietic cell lineage_Homo sapiens_hsa046400.49246860
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.48570159
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48045093
72Arachidonic acid metabolism_Homo sapiens_hsa005900.47969235
73Retinol metabolism_Homo sapiens_hsa008300.46364934
74GABAergic synapse_Homo sapiens_hsa047270.45000509
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44428219
76Leishmaniasis_Homo sapiens_hsa051400.44371977
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43920807
78Sulfur relay system_Homo sapiens_hsa041220.43648527
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43421717
80Salivary secretion_Homo sapiens_hsa049700.41168613
81Insulin secretion_Homo sapiens_hsa049110.40898267
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39953793
83beta-Alanine metabolism_Homo sapiens_hsa004100.37444005
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36913663
85Metabolic pathways_Homo sapiens_hsa011000.36620665
86Serotonergic synapse_Homo sapiens_hsa047260.36245950
87Base excision repair_Homo sapiens_hsa034100.35496123
88Mismatch repair_Homo sapiens_hsa034300.34243156
89Hedgehog signaling pathway_Homo sapiens_hsa043400.32593121
90Steroid biosynthesis_Homo sapiens_hsa001000.31941200
91Phagosome_Homo sapiens_hsa041450.31781612
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31527976
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26655577
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.26494238
95Calcium signaling pathway_Homo sapiens_hsa040200.26475450
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.26400442
97Fat digestion and absorption_Homo sapiens_hsa049750.26318211
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24191217
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22256789
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22055263

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