ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.98887670
2	ATP synthesis coupled proton transport (GO:0015986)	4.86946467
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.86946467
4	signal peptide processing (GO:0006465)	4.83992559
5	behavioral response to nicotine (GO:0035095)	4.61818960
6	DNA deamination (GO:0045006)	4.48341978
7	platelet dense granule organization (GO:0060155)	4.32613346
8	response to pheromone (GO:0019236)	3.83200330
9	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.81745051
10	protein complex biogenesis (GO:0070271)	3.76115129
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.69818988
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.58503293
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.57634251
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.57634251
15	GTP biosynthetic process (GO:0006183)	3.55664235
16	maturation of SSU-rRNA (GO:0030490)	3.53269854
17	L-fucose catabolic process (GO:0042355)	3.42435611
18	fucose catabolic process (GO:0019317)	3.42435611
19	L-fucose metabolic process (GO:0042354)	3.42435611
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42206648
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42206648
22	NADH dehydrogenase complex assembly (GO:0010257)	3.42206648
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42142911
24	somite development (GO:0061053)	3.35875395
25	nucleoside transmembrane transport (GO:1901642)	3.30708872
26	protein prenylation (GO:0018342)	3.30581738
27	prenylation (GO:0097354)	3.30581738
28	viral transcription (GO:0019083)	3.28485395
29	protein neddylation (GO:0045116)	3.27333636
30	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.22174542
31	striatum development (GO:0021756)	3.17410183
32	translational termination (GO:0006415)	3.15766905
33	ribosomal small subunit assembly (GO:0000028)	3.13937587
34	negative regulation of heart rate (GO:0010459)	3.06448440
35	GPI anchor metabolic process (GO:0006505)	3.02128939
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.00424540
37	protein targeting to ER (GO:0045047)	2.99238374
38	indolalkylamine metabolic process (GO:0006586)	2.99188932
39	negative regulation of telomere maintenance (GO:0032205)	2.98107451
40	kidney morphogenesis (GO:0060993)	2.96812927
41	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.96788697
42	chaperone-mediated protein transport (GO:0072321)	2.96488771
43	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.94708812
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.93090899
45	dopamine transport (GO:0015872)	2.92878951
46	electron transport chain (GO:0022900)	2.91552304
47	respiratory electron transport chain (GO:0022904)	2.91301422
48	intraciliary transport (GO:0042073)	2.90846909
49	cotranslational protein targeting to membrane (GO:0006613)	2.90246443
50	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.89194243
51	DNA ligation (GO:0006266)	2.88735585
52	termination of RNA polymerase III transcription (GO:0006386)	2.87472999
53	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.87472999
54	piRNA metabolic process (GO:0034587)	2.86310934
55	protein polyglutamylation (GO:0018095)	2.86267468
56	UTP biosynthetic process (GO:0006228)	2.86077251
57	negative regulation of membrane potential (GO:0045837)	2.85082120
58	axonemal dynein complex assembly (GO:0070286)	2.81036392
59	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.80879546
60	protein localization to endoplasmic reticulum (GO:0070972)	2.78660887
61	translational elongation (GO:0006414)	2.76174005
62	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.76158334
63	GPI anchor biosynthetic process (GO:0006506)	2.75170464
64	reflex (GO:0060004)	2.75076803
65	positive regulation of prostaglandin secretion (GO:0032308)	2.74844231
66	epithelial cilium movement (GO:0003351)	2.74483724
67	ATP biosynthetic process (GO:0006754)	2.73330898
68	cytochrome complex assembly (GO:0017004)	2.70522019
69	dentate gyrus development (GO:0021542)	2.70436582
70	aldehyde catabolic process (GO:0046185)	2.70037917
71	hydrogen ion transmembrane transport (GO:1902600)	2.69296219
72	rRNA modification (GO:0000154)	2.67434455
73	valine metabolic process (GO:0006573)	2.67428554
74	UTP metabolic process (GO:0046051)	2.67339773
75	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.66053198
76	proton transport (GO:0015992)	2.65982429
77	positive regulation of protein homodimerization activity (GO:0090073)	2.64481455
78	respiratory chain complex IV assembly (GO:0008535)	2.64167731
79	detection of light stimulus involved in visual perception (GO:0050908)	2.63987294
80	detection of light stimulus involved in sensory perception (GO:0050962)	2.63987294
81	kynurenine metabolic process (GO:0070189)	2.63778087
82	negative regulation of mast cell activation (GO:0033004)	2.63186915
83	indole-containing compound catabolic process (GO:0042436)	2.60238879
84	indolalkylamine catabolic process (GO:0046218)	2.60238879
85	tryptophan catabolic process (GO:0006569)	2.60238879
86	hydrogen transport (GO:0006818)	2.58141063
87	axoneme assembly (GO:0035082)	2.55741383
88	positive regulation of fatty acid transport (GO:2000193)	2.53492650
89	preassembly of GPI anchor in ER membrane (GO:0016254)	2.52185579
90	regulation of action potential (GO:0098900)	2.50376660
91	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49540959
92	substrate-independent telencephalic tangential migration (GO:0021826)	2.48482746
93	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.48482746
94	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.46915229
95	multicellular organism reproduction (GO:0032504)	2.45909476
96	viral life cycle (GO:0019058)	2.44261896
97	centriole replication (GO:0007099)	2.44159301
98	protein localization to cilium (GO:0061512)	2.43704570
99	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.43587577
100	ribosomal small subunit biogenesis (GO:0042274)	2.43444500

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	4.07449485
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.30618472
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.25671121
4	VDR_22108803_ChIP-Seq_LS180_Human	3.25243719
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.04414746
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.65651111
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.58837022
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.24270629
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24048978
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.19660505
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.11178029
12	EWS_26573619_Chip-Seq_HEK293_Human	2.11099580
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11001256
14	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.06004114
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.04655916
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.04457050
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.99330860
18	ER_23166858_ChIP-Seq_MCF-7_Human	1.92584749
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92261223
20	FUS_26573619_Chip-Seq_HEK293_Human	1.90977548
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.86975550
22	P300_19829295_ChIP-Seq_ESCs_Human	1.85444426
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83737387
24	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80358367
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68038769
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.67723663
27	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.67493310
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64507192
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.58071697
30	SOX2_19829295_ChIP-Seq_ESCs_Human	1.57721003
31	NANOG_19829295_ChIP-Seq_ESCs_Human	1.57721003
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57643577
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.53404619
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.53404619
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.52283776
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.51538619
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50952704
38	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.50225368
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49783941
40	AR_21572438_ChIP-Seq_LNCaP_Human	1.49196924
41	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48216995
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.46401693
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.46401693
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.45327943
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.40062447
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.39232522
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37311638
48	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36598035
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.35364010
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.34639169
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32903491
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.32283792
53	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32277725
54	AR_25329375_ChIP-Seq_VCAP_Human	1.32220795
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.32121143
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30438675
57	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.30095300
58	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.29212023
59	TP53_22573176_ChIP-Seq_HFKS_Human	1.27930829
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27432789
61	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26314530
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.24414796
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22591512
64	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.20093586
65	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.19897823
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.17791752
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16860812
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16656311
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.15357989
70	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14941759
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14888156
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14828092
73	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13661886
74	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13369458
75	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.10984779
76	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10923970
77	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.08725560
78	AR_20517297_ChIP-Seq_VCAP_Human	1.08680684
79	GATA3_26560356_Chip-Seq_TH2_Human	1.08107005
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06554771
81	STAT3_23295773_ChIP-Seq_U87_Human	1.04895645
82	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03992012
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.03881284
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.02578517
85	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02433024
86	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01450994
87	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01329267
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01178979
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00841060
90	TCF4_23295773_ChIP-Seq_U87_Human	0.99629901
91	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.99072092
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97789896
93	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.97746215
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.97705430
95	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97705430
96	ERA_21632823_ChIP-Seq_H3396_Human	0.96490860
97	NCOR_22424771_ChIP-Seq_293T_Human	0.96301377
98	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.96172647
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.96052693
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94737924

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.47090523
2	MP0003880_abnormal_central_pattern	3.60568007
3	MP0010030_abnormal_orbit_morphology	3.60527381
4	MP0003646_muscle_fatigue	3.08555100
5	MP0002102_abnormal_ear_morphology	2.95536284
6	MP0004145_abnormal_muscle_electrophysio	2.50665749
7	MP0002653_abnormal_ependyma_morphology	2.33489241
8	MP0006072_abnormal_retinal_apoptosis	2.10061567
9	MP0005551_abnormal_eye_electrophysiolog	2.07914936
10	MP0008872_abnormal_physiological_respon	1.95305384
11	MP0005248_abnormal_Harderian_gland	1.92762194
12	MP0005671_abnormal_response_to	1.87612176
13	MP0005084_abnormal_gallbladder_morpholo	1.86903022
14	MP0001835_abnormal_antigen_presentation	1.83332346
15	MP0006276_abnormal_autonomic_nervous	1.82241032
16	MP0008877_abnormal_DNA_methylation	1.74616453
17	MP0006292_abnormal_olfactory_placode	1.68548807
18	MP0002638_abnormal_pupillary_reflex	1.65910603
19	MP0008995_early_reproductive_senescence	1.64879025
20	MP0005253_abnormal_eye_physiology	1.62084966
21	MP0004142_abnormal_muscle_tone	1.61507621
22	MP0002736_abnormal_nociception_after	1.52169348
23	MP0000685_abnormal_immune_system	1.50952290
24	MP0004742_abnormal_vestibular_system	1.46212867
25	MP0005645_abnormal_hypothalamus_physiol	1.46203054
26	MP0002282_abnormal_trachea_morphology	1.42786111
27	MP0000569_abnormal_digit_pigmentation	1.41594501
28	MP0002095_abnormal_skin_pigmentation	1.40202908
29	MP0000427_abnormal_hair_cycle	1.40028106
30	MP0004147_increased_porphyrin_level	1.39693627
31	MP0002234_abnormal_pharynx_morphology	1.38406838
32	MP0004885_abnormal_endolymph	1.38159763
33	MP0009745_abnormal_behavioral_response	1.28608153
34	MP0001968_abnormal_touch/_nociception	1.27321694
35	MP0008875_abnormal_xenobiotic_pharmacok	1.24834272
36	MP0000778_abnormal_nervous_system	1.22004773
37	MP0002272_abnormal_nervous_system	1.21192887
38	MP0005195_abnormal_posterior_eye	1.19760359
39	MP0000372_irregular_coat_pigmentation	1.18502743
40	MP0005377_hearing/vestibular/ear_phenot	1.17793058
41	MP0003878_abnormal_ear_physiology	1.17793058
42	MP0005646_abnormal_pituitary_gland	1.16094888
43	MP0001986_abnormal_taste_sensitivity	1.13054709
44	MP0002233_abnormal_nose_morphology	1.12968589
45	MP0005389_reproductive_system_phenotype	1.12874756
46	MP0005379_endocrine/exocrine_gland_phen	1.12201481
47	MP0001919_abnormal_reproductive_system	1.11748367
48	MP0001293_anophthalmia	1.10696200
49	MP0005075_abnormal_melanosome_morpholog	1.09326027
50	MP0000534_abnormal_ureter_morphology	1.09107127
51	MP0001486_abnormal_startle_reflex	1.07876514
52	MP0001984_abnormal_olfaction	1.07798923
53	MP0009046_muscle_twitch	1.07663079
54	MP0001800_abnormal_humoral_immune	1.06896824
55	MP0003011_delayed_dark_adaptation	1.06471948
56	MP0002752_abnormal_somatic_nervous	1.05106231
57	MP0001286_abnormal_eye_development	1.04775027
58	MP0008775_abnormal_heart_ventricle	1.04354153
59	MP0005174_abnormal_tail_pigmentation	1.03118046
60	MP0005387_immune_system_phenotype	1.02325286
61	MP0001790_abnormal_immune_system	1.02325286
62	MP0001485_abnormal_pinna_reflex	1.00965693
63	MP0002876_abnormal_thyroid_physiology	0.98755290
64	MP0002184_abnormal_innervation	0.98297393
65	MP0001970_abnormal_pain_threshold	0.97976968
66	MP0002751_abnormal_autonomic_nervous	0.96858370
67	MP0002938_white_spotting	0.95527075
68	MP0003186_abnormal_redox_activity	0.95443972
69	MP0006054_spinal_hemorrhage	0.93970547
70	MP0009764_decreased_sensitivity_to	0.93917750
71	MP0000613_abnormal_salivary_gland	0.92023532
72	MP0005410_abnormal_fertilization	0.91185695
73	MP0003787_abnormal_imprinting	0.91125154
74	MP0002837_dystrophic_cardiac_calcinosis	0.89498495
75	MP0005423_abnormal_somatic_nervous	0.89139970
76	MP0001905_abnormal_dopamine_level	0.89131873
77	MP0000026_abnormal_inner_ear	0.89091888
78	MP0002229_neurodegeneration	0.88902230
79	MP0002160_abnormal_reproductive_system	0.88701562
80	MP0008789_abnormal_olfactory_epithelium	0.87050725
81	MP0000230_abnormal_systemic_arterial	0.85543337
82	MP0002163_abnormal_gland_morphology	0.84955451
83	MP0005171_absent_coat_pigmentation	0.84022593
84	MP0002210_abnormal_sex_determination	0.83716140
85	MP0003718_maternal_effect	0.82827546
86	MP0000647_abnormal_sebaceous_gland	0.82688765
87	MP0002557_abnormal_social/conspecific_i	0.81758775
88	MP0001529_abnormal_vocalization	0.81267113
89	MP0002067_abnormal_sensory_capabilities	0.80299086
90	MP0005391_vision/eye_phenotype	0.79995049
91	MP0005197_abnormal_uvea_morphology	0.79481810
92	MP0001440_abnormal_grooming_behavior	0.77657343
93	MP0003122_maternal_imprinting	0.77538671
94	MP0001929_abnormal_gametogenesis	0.77095924
95	MP0002572_abnormal_emotion/affect_behav	0.76055957
96	MP0001501_abnormal_sleep_pattern	0.76019102
97	MP0003195_calcinosis	0.74602591
98	MP0001663_abnormal_digestive_system	0.72499334
99	MP0003698_abnormal_male_reproductive	0.72323793
100	MP0004133_heterotaxia	0.71402938

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.61300500
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.24989349
3	Absent/shortened dynein arms (HP:0200106)	4.24989349
4	Abnormality of midbrain morphology (HP:0002418)	4.00185335
5	Molar tooth sign on MRI (HP:0002419)	4.00185335
6	Abnormal rod and cone electroretinograms (HP:0008323)	3.99919600
7	Pancreatic cysts (HP:0001737)	3.90958995
8	Pancreatic fibrosis (HP:0100732)	3.88130656
9	Attenuation of retinal blood vessels (HP:0007843)	3.65833724
10	True hermaphroditism (HP:0010459)	3.55648695
11	Pendular nystagmus (HP:0012043)	3.53868833
12	Abnormal pancreas size (HP:0012094)	3.46646084
13	Decreased central vision (HP:0007663)	3.42189635
14	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.32647331
15	3-Methylglutaconic aciduria (HP:0003535)	3.28054867
16	Abnormal ciliary motility (HP:0012262)	2.96640643
17	Abnormal respiratory motile cilium morphology (HP:0005938)	2.96093064
18	Abnormal respiratory epithelium morphology (HP:0012253)	2.96093064
19	Nephronophthisis (HP:0000090)	2.95275473
20	Acute necrotizing encephalopathy (HP:0006965)	2.94627873
21	Congenital stationary night blindness (HP:0007642)	2.93099944
22	Medial flaring of the eyebrow (HP:0010747)	2.86819783
23	Reticulocytopenia (HP:0001896)	2.84169610
24	Abnormal respiratory motile cilium physiology (HP:0012261)	2.82053688
25	Anophthalmia (HP:0000528)	2.80800641
26	Annular pancreas (HP:0001734)	2.77622169
27	Mitochondrial inheritance (HP:0001427)	2.71432132
28	Abnormality of the renal cortex (HP:0011035)	2.69220586
29	Abnormality of the renal medulla (HP:0100957)	2.69181926
30	Acute encephalopathy (HP:0006846)	2.65531388
31	Polyuria (HP:0000103)	2.63281128
32	Abnormal lung lobation (HP:0002101)	2.63231340
33	Anencephaly (HP:0002323)	2.58713041
34	Lipid accumulation in hepatocytes (HP:0006561)	2.58362377
35	Increased CSF lactate (HP:0002490)	2.57477607
36	Increased hepatocellular lipid droplets (HP:0006565)	2.48780037
37	Abnormal mitochondria in muscle tissue (HP:0008316)	2.46767666
38	Metabolic alkalosis (HP:0200114)	2.43058977
39	Optic disc pallor (HP:0000543)	2.42457306
40	Abolished electroretinogram (ERG) (HP:0000550)	2.41640352
41	Sclerocornea (HP:0000647)	2.38186399
42	Cystic liver disease (HP:0006706)	2.37264977
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.34740800
44	Progressive macrocephaly (HP:0004481)	2.33816532
45	Type 2 muscle fiber atrophy (HP:0003554)	2.29347056
46	Supernumerary spleens (HP:0009799)	2.26791021
47	Hypokalemic alkalosis (HP:0001949)	2.24131961
48	IgG deficiency (HP:0004315)	2.23799253
49	Abnormal urine output (HP:0012590)	2.23148638
50	Abnormality of renal resorption (HP:0011038)	2.20663508
51	Increased corneal curvature (HP:0100692)	2.19960214
52	Keratoconus (HP:0000563)	2.19960214
53	Hepatocellular necrosis (HP:0001404)	2.19577093
54	Postaxial foot polydactyly (HP:0001830)	2.19413338
55	Constricted visual fields (HP:0001133)	2.15752605
56	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13424222
57	Abnormality of alanine metabolism (HP:0010916)	2.13424222
58	Hyperalaninemia (HP:0003348)	2.13424222
59	Hyperglycinemia (HP:0002154)	2.13094006
60	Hypoproteinemia (HP:0003075)	2.11442361
61	Recurrent sinusitis (HP:0011108)	2.09765313
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07933088
63	Cerebral palsy (HP:0100021)	2.05705831
64	Type II lissencephaly (HP:0007260)	2.04158815
65	Thyroiditis (HP:0100646)	2.02446086
66	Abnormality of renal excretion (HP:0011036)	2.00947534
67	Abnormality of cells of the erythroid lineage (HP:0012130)	2.00672510
68	Muscle fiber atrophy (HP:0100295)	1.99205295
69	Tubular atrophy (HP:0000092)	1.99063712
70	Bony spicule pigmentary retinopathy (HP:0007737)	1.98794406
71	Severe combined immunodeficiency (HP:0004430)	1.96742184
72	Gait imbalance (HP:0002141)	1.93206498
73	Hyperglycinuria (HP:0003108)	1.91157611
74	Increased circulating renin level (HP:0000848)	1.88838956
75	Alkalosis (HP:0001948)	1.87718914
76	Bicornuate uterus (HP:0000813)	1.86735429
77	Congenital, generalized hypertrichosis (HP:0004540)	1.86468199
78	Renal salt wasting (HP:0000127)	1.82381603
79	Limb hypertonia (HP:0002509)	1.82200182
80	Hepatic necrosis (HP:0002605)	1.82159839
81	Bile duct proliferation (HP:0001408)	1.81935880
82	Abnormal biliary tract physiology (HP:0012439)	1.81935880
83	Occipital encephalocele (HP:0002085)	1.81578065
84	Disinhibition (HP:0000734)	1.79238242
85	Abnormal drinking behavior (HP:0030082)	1.78689190
86	Polydipsia (HP:0001959)	1.78689190
87	Renal Fanconi syndrome (HP:0001994)	1.78084372
88	Optic nerve hypoplasia (HP:0000609)	1.76896375
89	Exertional dyspnea (HP:0002875)	1.76395028
90	Intestinal atresia (HP:0011100)	1.74849082
91	Congenital primary aphakia (HP:0007707)	1.74822317
92	Congenital hepatic fibrosis (HP:0002612)	1.74796030
93	Pallor (HP:0000980)	1.74126560
94	Absent speech (HP:0001344)	1.73151417
95	Increased serum lactate (HP:0002151)	1.72949608
96	Rhinitis (HP:0012384)	1.72259190
97	Abnormal number of erythroid precursors (HP:0012131)	1.70091954
98	Lissencephaly (HP:0001339)	1.68275184
99	Hypomagnesemia (HP:0002917)	1.68116580
100	Preaxial hand polydactyly (HP:0001177)	1.67689106

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.69201983
2	FRK	2.79254437
3	GRK1	2.43080632
4	PINK1	2.37849921
5	WNK3	2.34006604
6	ADRBK2	2.30450914
7	MAP3K4	2.23385846
8	MAP3K12	2.20732805
9	ZAK	2.18307482
10	MAP4K2	2.15379877
11	WNK4	2.12789774
12	INSRR	2.05781723
13	MAP2K7	2.02316457
14	BMPR2	1.83781196
15	CDK19	1.82831905
16	TIE1	1.79776973
17	TXK	1.76599605
18	ACVR1B	1.65655463
19	NUAK1	1.60171071
20	GRK6	1.59298400
21	MAPK13	1.53122179
22	BMPR1B	1.47554415
23	TNIK	1.46258433
24	STK16	1.44648298
25	NME1	1.37051817
26	CAMKK2	1.35040056
27	OXSR1	1.34654293
28	STK39	1.29943896
29	PLK4	1.27958304
30	STK38L	1.23896157
31	DYRK2	1.21974214
32	KDR	1.19298942
33	CASK	1.12326416
34	DAPK2	1.08913518
35	PIK3CG	1.07422941
36	PLK2	1.06701629
37	MYLK	1.04592021
38	TEC	1.02891655
39	MAP3K6	1.01234564
40	VRK2	0.96056614
41	VRK1	0.91425032
42	MARK1	0.89207670
43	FES	0.88226097
44	MAP3K11	0.85031393
45	CCNB1	0.84392101
46	ILK	0.84265136
47	KIT	0.83962995
48	PKN1	0.83482711
49	PAK3	0.82308661
50	PLK3	0.80976794
51	EPHA4	0.78339157
52	PRKCQ	0.77247137
53	TGFBR1	0.74061094
54	ERBB3	0.73667865
55	OBSCN	0.73167663
56	PIK3CA	0.72307990
57	PASK	0.70647087
58	ERBB2	0.70398913
59	GRK7	0.70121008
60	BRSK2	0.70101500
61	PTK2B	0.69808588
62	SYK	0.68317778
63	IKBKB	0.67469499
64	BTK	0.67382545
65	CAMK1	0.66068973
66	CDK8	0.65290941
67	TAOK3	0.64715884
68	ADRBK1	0.64231713
69	NLK	0.60275425
70	CSNK1G2	0.59806370
71	PRKACA	0.59174524
72	PHKG2	0.59056048
73	PHKG1	0.59056048
74	DAPK3	0.58161667
75	NTRK3	0.57762712
76	NME2	0.57501974
77	PRKCG	0.56986818
78	MARK3	0.54323527
79	TYRO3	0.52217721
80	RIPK4	0.52083111
81	RPS6KA5	0.52027977
82	MST4	0.51399842
83	MATK	0.50885911
84	MAPK15	0.50865477
85	TSSK6	0.50445711
86	TRIM28	0.49540005
87	MKNK2	0.48882069
88	BCKDK	0.48825206
89	AURKB	0.48767336
90	TRPM7	0.48476285
91	CSNK2A2	0.47780174
92	WEE1	0.47308110
93	LCK	0.45075758
94	IGF1R	0.44919530
95	ROCK1	0.42541160
96	CSNK2A1	0.42386526
97	ITK	0.41300941
98	STK24	0.40824104
99	CAMKK1	0.40676634
100	PRKCA	0.40125741

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.05725513
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.24300825
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.18462583
4	Allograft rejection_Homo sapiens_hsa05330	3.17144767
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.05465651
6	Ribosome_Homo sapiens_hsa03010	2.96153374
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.80510123
8	Protein export_Homo sapiens_hsa03060	2.75713914
9	Parkinsons disease_Homo sapiens_hsa05012	2.71053759
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.48459117
11	Proteasome_Homo sapiens_hsa03050	2.35521234
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23239586
13	RNA polymerase_Homo sapiens_hsa03020	1.90224733
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.81687268
15	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.81355129
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.79319046
17	Alzheimers disease_Homo sapiens_hsa05010	1.75792155
18	Huntingtons disease_Homo sapiens_hsa05016	1.75604197
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73302860
20	Phototransduction_Homo sapiens_hsa04744	1.73076534
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.58055917
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57298038
23	Regulation of autophagy_Homo sapiens_hsa04140	1.56579596
24	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.56276539
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.49416540
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.47334164
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.42169128
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39385378
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.36989929
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33053563
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.31108193
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.27858042
33	Homologous recombination_Homo sapiens_hsa03440	1.27124614
34	Caffeine metabolism_Homo sapiens_hsa00232	1.26986106
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.13836452
36	RNA degradation_Homo sapiens_hsa03018	1.13414270
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.13111701
38	Olfactory transduction_Homo sapiens_hsa04740	1.11040778
39	Viral myocarditis_Homo sapiens_hsa05416	1.04356318
40	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.03345511
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.99099539
42	Peroxisome_Homo sapiens_hsa04146	0.92496398
43	One carbon pool by folate_Homo sapiens_hsa00670	0.90237469
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88852495
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.88764092
46	Nicotine addiction_Homo sapiens_hsa05033	0.85573824
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82966722
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77761341
49	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75249732
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74038408
51	Taste transduction_Homo sapiens_hsa04742	0.73937197
52	Propanoate metabolism_Homo sapiens_hsa00640	0.72762531
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.70331944
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70320525
55	ABC transporters_Homo sapiens_hsa02010	0.68628935
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.64665983
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.62979147
58	Purine metabolism_Homo sapiens_hsa00230	0.61839236
59	Butanoate metabolism_Homo sapiens_hsa00650	0.61039379
60	RNA transport_Homo sapiens_hsa03013	0.59576501
61	Morphine addiction_Homo sapiens_hsa05032	0.56970548
62	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55922979
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54537051
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.54118793
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.53821929
66	Basal transcription factors_Homo sapiens_hsa03022	0.51409072
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50154576
68	Pyrimidine metabolism_Homo sapiens_hsa00240	0.49664127
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49246860
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48570159
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48045093
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47969235
73	Retinol metabolism_Homo sapiens_hsa00830	0.46364934
74	GABAergic synapse_Homo sapiens_hsa04727	0.45000509
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44428219
76	Leishmaniasis_Homo sapiens_hsa05140	0.44371977
77	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43920807
78	Sulfur relay system_Homo sapiens_hsa04122	0.43648527
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.43421717
80	Salivary secretion_Homo sapiens_hsa04970	0.41168613
81	Insulin secretion_Homo sapiens_hsa04911	0.40898267
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39953793
83	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37444005
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36913663
85	Metabolic pathways_Homo sapiens_hsa01100	0.36620665
86	Serotonergic synapse_Homo sapiens_hsa04726	0.36245950
87	Base excision repair_Homo sapiens_hsa03410	0.35496123
88	Mismatch repair_Homo sapiens_hsa03430	0.34243156
89	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.32593121
90	Steroid biosynthesis_Homo sapiens_hsa00100	0.31941200
91	Phagosome_Homo sapiens_hsa04145	0.31781612
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31527976
93	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.26655577
94	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.26494238
95	Calcium signaling pathway_Homo sapiens_hsa04020	0.26475450
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.26400442
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.26318211
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24191217
99	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.22256789
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.22055263

EEF1B2P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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