ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	coenzyme catabolic process (GO:0009109)	8.92252308
2	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	8.39217959
3	polyol transport (GO:0015791)	7.69550997
4	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	7.69425188
5	regulation of isotype switching to IgG isotypes (GO:0048302)	6.31602369
6	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	5.93411854
7	positive regulation of lamellipodium assembly (GO:0010592)	5.67394921
8	negative regulation of T cell differentiation in thymus (GO:0033085)	5.56124623
9	regulation of regulatory T cell differentiation (GO:0045589)	5.45813836
10	cofactor catabolic process (GO:0051187)	5.34051727
11	negative regulation of macrophage differentiation (GO:0045650)	5.27544418
12	protein neddylation (GO:0045116)	5.13693581
13	phosphatidylinositol acyl-chain remodeling (GO:0036149)	5.07448665
14	positive regulation of interleukin-17 production (GO:0032740)	5.06868793
15	regulation of cell-cell adhesion mediated by cadherin (GO:2000047)	5.02050852
16	regulation of immunoglobulin secretion (GO:0051023)	4.91744488
17	auditory receptor cell stereocilium organization (GO:0060088)	4.86434198
18	GTP biosynthetic process (GO:0006183)	4.50825706
19	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	4.46014237
20	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.39961740
21	positive regulation of lamellipodium organization (GO:1902745)	4.37089029
22	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	4.34087187
23	signal peptide processing (GO:0006465)	4.27681851
24	negative regulation of B cell apoptotic process (GO:0002903)	4.24313444
25	UTP biosynthetic process (GO:0006228)	4.13504445
26	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	4.10430026
27	positive regulation of isotype switching (GO:0045830)	4.02499908
28	intracellular pH reduction (GO:0051452)	3.94519892
29	DNA double-strand break processing (GO:0000729)	3.89225976
30	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.84930797
31	ribosomal small subunit assembly (GO:0000028)	3.80029939
32	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.79067157
33	spermatid nucleus differentiation (GO:0007289)	3.77039522
34	UTP metabolic process (GO:0046051)	3.68644502
35	regulation of lamellipodium assembly (GO:0010591)	3.66897702
36	nephron tubule development (GO:0072080)	3.64008044
37	negative regulation of histone acetylation (GO:0035067)	3.63166120
38	photoreceptor cell maintenance (GO:0045494)	3.62827922
39	positive regulation of gluconeogenesis (GO:0045722)	3.60578601
40	synapsis (GO:0007129)	3.51307952
41	positive regulation of DNA recombination (GO:0045911)	3.48643525
42	regulation of Golgi to plasma membrane protein transport (GO:0042996)	3.46958225
43	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.37480073
44	regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	3.28387112
45	pH reduction (GO:0045851)	3.26982476
46	G-protein coupled receptor internalization (GO:0002031)	3.19581595
47	negative regulation of thymocyte apoptotic process (GO:0070244)	3.16310213
48	renal tubule development (GO:0061326)	3.14939671
49	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.13659990
50	positive regulation of prostaglandin secretion (GO:0032308)	3.13623311
51	very long-chain fatty acid metabolic process (GO:0000038)	3.13374290
52	guanosine-containing compound biosynthetic process (GO:1901070)	3.12976604
53	ether lipid metabolic process (GO:0046485)	3.12858606
54	regulation of prostaglandin secretion (GO:0032306)	3.12848471
55	positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	3.11061454
56	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.10057122
57	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.09311707
58	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.03302046
59	pinocytosis (GO:0006907)	3.03131016
60	positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)	2.99391992
61	regulation of B cell apoptotic process (GO:0002902)	2.98037913
62	negative regulation of JAK-STAT cascade (GO:0046426)	2.97020207
63	CTP biosynthetic process (GO:0006241)	2.96101579
64	CTP metabolic process (GO:0046036)	2.96101579
65	regulation of integrin activation (GO:0033623)	2.90758481
66	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.88092371
67	linoleic acid metabolic process (GO:0043651)	2.87440819
68	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.86887658
69	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.85864534
70	lipopolysaccharide biosynthetic process (GO:0009103)	2.81744991
71	cell wall macromolecule catabolic process (GO:0016998)	2.81456440
72	maturation of 5.8S rRNA (GO:0000460)	2.81272425
73	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.81151180
74	DNA excision (GO:0044349)	2.81151180
75	nephron epithelium development (GO:0072009)	2.78759664
76	forebrain morphogenesis (GO:0048853)	2.78003570
77	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.77743119
78	inner ear receptor stereocilium organization (GO:0060122)	2.77628378
79	ribosome biogenesis (GO:0042254)	2.75805264
80	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.74063192
81	ATP synthesis coupled proton transport (GO:0015986)	2.74063192
82	mitochondrion degradation (GO:0000422)	2.72972807
83	viral transcription (GO:0019083)	2.72849184
84	negative regulation of peptidyl-lysine acetylation (GO:2000757)	2.71321541
85	oxidative demethylation (GO:0070989)	2.70357659
86	regulation of lamellipodium organization (GO:1902743)	2.68798867
87	cilium or flagellum-dependent cell motility (GO:0001539)	2.66910740
88	positive regulation of fatty acid transport (GO:2000193)	2.66542555
89	negative regulation of lymphocyte apoptotic process (GO:0070229)	2.66182825
90	carnitine metabolic process (GO:0009437)	2.65600047
91	negative regulation of lipid storage (GO:0010888)	2.63385390
92	phosphatidylserine metabolic process (GO:0006658)	2.62556467
93	quinone metabolic process (GO:1901661)	2.62319019
94	embryonic hemopoiesis (GO:0035162)	2.61855675
95	fatty acid elongation (GO:0030497)	2.61233263
96	protoporphyrinogen IX metabolic process (GO:0046501)	2.61003424
97	protein polyglutamylation (GO:0018095)	2.60344844
98	DNA demethylation (GO:0080111)	2.58085788
99	positive regulation of histone H3-K4 methylation (GO:0051571)	2.57764907
100	one-carbon compound transport (GO:0019755)	10.0010327

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.71429480
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.81037226
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41270491
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.20659198
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.71279918
6	VDR_22108803_ChIP-Seq_LS180_Human	2.65421184
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40327282
8	EWS_26573619_Chip-Seq_HEK293_Human	2.37457396
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.33866694
10	MYC_18940864_ChIP-ChIP_HL60_Human	2.29770510
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.26116661
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.24523073
13	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.21857119
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.21273068
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.13756783
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.10908733
17	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.08796891
18	CBP_20019798_ChIP-Seq_JUKART_Human	2.08796891
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06214483
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05772583
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.99558905
22	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.94065038
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.90462372
24	EZH2_22144423_ChIP-Seq_EOC_Human	1.89714487
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.84578097
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.79772757
27	P300_19829295_ChIP-Seq_ESCs_Human	1.79700179
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.75416652
29	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.74180694
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72963014
31	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.72498483
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70557190
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70447805
34	NCOR_22424771_ChIP-Seq_293T_Human	1.69324634
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.69262775
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.68911381
37	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65313636
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.64254980
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58803972
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.57934593
41	GBX2_23144817_ChIP-Seq_PC3_Human	1.55606120
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54831809
43	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.54071380
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.51161186
45	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.49429787
46	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46707742
47	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45742688
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42350589
49	CDX2_22108803_ChIP-Seq_LS180_Human	1.40745344
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38265573
51	FUS_26573619_Chip-Seq_HEK293_Human	1.36603130
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.35389859
53	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.33870208
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.30293606
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28877022
56	TP53_16413492_ChIP-PET_HCT116_Human	1.27960540
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26794833
58	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.23229429
59	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.20755495
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20045159
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18351600
62	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.18043129
63	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.15925940
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12869920
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12869920
66	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.12280715
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10858230
68	TTF2_22483619_ChIP-Seq_HELA_Human	1.10404865
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.09865791
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08887494
71	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.07305091
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05768003
73	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.04948721
74	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04860387
75	RUNX_20019798_ChIP-Seq_JUKART_Human	1.03735784
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02536357
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02536357
78	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02421679
79	MYC_19829295_ChIP-Seq_ESCs_Human	1.01891379
80	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00830850
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98714983
82	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96763481
83	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95983018
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95357717
85	RUNX2_22187159_ChIP-Seq_PCA_Human	0.93911659
86	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.93798427
87	MYB_26560356_Chip-Seq_TH1_Human	0.93217766
88	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.91697670
89	GATA3_26560356_Chip-Seq_TH2_Human	0.90902895
90	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.90095664
91	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.89534847
92	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.89083882
93	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.89057168
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.88672960
95	P300_18555785_Chip-Seq_ESCs_Mouse	0.88112754
96	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.87891123
97	STAT3_23295773_ChIP-Seq_U87_Human	0.87493080
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.87434203
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87350043
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.87314693

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000566_synostosis	5.76566070
2	MP0004147_increased_porphyrin_level	4.75938518
3	MP0002138_abnormal_hepatobiliary_system	3.32993674
4	MP0002736_abnormal_nociception_after	3.10776112
5	MP0002009_preneoplasia	3.00471311
6	MP0005410_abnormal_fertilization	2.68853746
7	MP0006292_abnormal_olfactory_placode	2.40017827
8	MP0003806_abnormal_nucleotide_metabolis	2.38985264
9	MP0002160_abnormal_reproductive_system	2.34940807
10	MP0002166_altered_tumor_susceptibility	2.33639895
11	MP0001853_heart_inflammation	2.32659086
12	MP0001984_abnormal_olfaction	2.30319207
13	MP0004742_abnormal_vestibular_system	2.27321559
14	MP0001968_abnormal_touch/_nociception	2.13652800
15	MP0005647_abnormal_sex_gland	2.10674499
16	MP0001835_abnormal_antigen_presentation	2.07154640
17	MP0004885_abnormal_endolymph	2.04114855
18	MP0005389_reproductive_system_phenotype	2.01808632
19	MP0005671_abnormal_response_to	1.97020032
20	MP0003880_abnormal_central_pattern	1.95217286
21	MP0003718_maternal_effect	1.91954808
22	MP0005551_abnormal_eye_electrophysiolog	1.91586702
23	MP0009278_abnormal_bone_marrow	1.88557662
24	MP0001664_abnormal_digestion	1.87285203
25	MP0002006_tumorigenesis	1.79735381
26	MP0005423_abnormal_somatic_nervous	1.65462742
27	MP0005084_abnormal_gallbladder_morpholo	1.51607029
28	MP0002148_abnormal_hypersensitivity_rea	1.50949206
29	MP0004145_abnormal_muscle_electrophysio	1.50557249
30	MP0002234_abnormal_pharynx_morphology	1.48557815
31	MP0003646_muscle_fatigue	1.45563625
32	MP0002837_dystrophic_cardiac_calcinosis	1.42685525
33	MP0005646_abnormal_pituitary_gland	1.41325071
34	MP0008007_abnormal_cellular_replicative	1.39243038
35	MP0005397_hematopoietic_system_phenotyp	1.39206335
36	MP0001545_abnormal_hematopoietic_system	1.39206335
37	MP0005253_abnormal_eye_physiology	1.36548730
38	MP0003763_abnormal_thymus_physiology	1.35742854
39	MP0002938_white_spotting	1.35552513
40	MP0004782_abnormal_surfactant_physiolog	1.31879545
41	MP0000465_gastrointestinal_hemorrhage	1.30666219
42	MP0003300_gastrointestinal_ulcer	1.27940886
43	MP0008058_abnormal_DNA_repair	1.25312264
44	MP0001905_abnormal_dopamine_level	1.20995201
45	MP0001919_abnormal_reproductive_system	1.20749188
46	MP0002909_abnormal_adrenal_gland	1.19684515
47	MP0004264_abnormal_extraembryonic_tissu	1.15501739
48	MP0000538_abnormal_urinary_bladder	1.13704819
49	MP0003786_premature_aging	1.07641911
50	MP0004272_abnormal_basement_membrane	1.06913875
51	MP0000343_altered_response_to	1.05668136
52	MP0001873_stomach_inflammation	1.05382662
53	MP0009840_abnormal_foam_cell	1.05348103
54	MP0001986_abnormal_taste_sensitivity	1.05315070
55	MP0001485_abnormal_pinna_reflex	1.04926370
56	MP0000604_amyloidosis	1.04922773
57	MP0005332_abnormal_amino_acid	1.02997004
58	MP0001963_abnormal_hearing_physiology	1.02015157
59	MP0003119_abnormal_digestive_system	1.00876312
60	MP0001188_hyperpigmentation	0.98768121
61	MP0001663_abnormal_digestive_system	0.95055977
62	MP0003866_abnormal_defecation	0.94535211
63	MP0010094_abnormal_chromosome_stability	0.92943974
64	MP0004484_altered_response_of	0.92060155
65	MP0003950_abnormal_plasma_membrane	0.92044134
66	MP0003303_peritoneal_inflammation	0.91004602
67	MP0008775_abnormal_heart_ventricle	0.90679374
68	MP0008877_abnormal_DNA_methylation	0.84360606
69	MP0002277_abnormal_respiratory_mucosa	0.84279777
70	MP0004808_abnormal_hematopoietic_stem	0.83963704
71	MP0002653_abnormal_ependyma_morphology	0.83838100
72	MP0008872_abnormal_physiological_respon	0.83816836
73	MP0002163_abnormal_gland_morphology	0.83014518
74	MP0003186_abnormal_redox_activity	0.82630454
75	MP0004133_heterotaxia	0.80804609
76	MP0003698_abnormal_male_reproductive	0.78750749
77	MP0009379_abnormal_foot_pigmentation	0.78149269
78	MP0005310_abnormal_salivary_gland	0.76109110
79	MP0002272_abnormal_nervous_system	0.71499158
80	MP0000609_abnormal_liver_physiology	0.71084745
81	MP0005360_urolithiasis	0.70464182
82	MP0001845_abnormal_inflammatory_respons	0.70409912
83	MP0000470_abnormal_stomach_morphology	0.70091797
84	MP0003943_abnormal_hepatobiliary_system	0.69715708
85	MP0000516_abnormal_urinary_system	0.69676267
86	MP0005367_renal/urinary_system_phenotyp	0.69676267
87	MP0001293_anophthalmia	0.69537778
88	MP0002282_abnormal_trachea_morphology	0.68276494
89	MP0005075_abnormal_melanosome_morpholog	0.67180501
90	MP0004084_abnormal_cardiac_muscle	0.67084015
91	MP0002136_abnormal_kidney_physiology	0.67007438
92	MP0000026_abnormal_inner_ear	0.66711050
93	MP0002933_joint_inflammation	0.66506972
94	MP0008469_abnormal_protein_level	0.65860764
95	MP0001486_abnormal_startle_reflex	0.65756173
96	MP0004036_abnormal_muscle_relaxation	0.64022504
97	MP0009765_abnormal_xenobiotic_induced	0.62723330
98	MP0001348_abnormal_lacrimal_gland	0.62646334
99	MP0005395_other_phenotype	0.61988026
100	MP0003937_abnormal_limbs/digits/tail_de	0.61473751

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	8.82209537
2	Absent/shortened dynein arms (HP:0200106)	7.72179722
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.72179722
4	Bile duct proliferation (HP:0001408)	5.74486265
5	Abnormal biliary tract physiology (HP:0012439)	5.74486265
6	Abnormal rod and cone electroretinograms (HP:0008323)	5.64728768
7	Abnormal ciliary motility (HP:0012262)	5.16306874
8	Abnormal respiratory motile cilium morphology (HP:0005938)	4.76961833
9	Abnormal respiratory epithelium morphology (HP:0012253)	4.76961833
10	Decreased central vision (HP:0007663)	4.50297274
11	3-Methylglutaconic aciduria (HP:0003535)	4.06556819
12	Abnormal respiratory motile cilium physiology (HP:0012261)	3.99401383
13	Attenuation of retinal blood vessels (HP:0007843)	3.92839182
14	Hyperglycinuria (HP:0003108)	3.84399985
15	Bony spicule pigmentary retinopathy (HP:0007737)	3.64831842
16	Supernumerary spleens (HP:0009799)	3.50395036
17	Renal cortical cysts (HP:0000803)	3.46514177
18	Gonadal dysgenesis (HP:0000133)	3.31565346
19	Microvesicular hepatic steatosis (HP:0001414)	3.24679692
20	Type II lissencephaly (HP:0007260)	2.98318708
21	True hermaphroditism (HP:0010459)	2.97589976
22	Chorioretinal atrophy (HP:0000533)	2.95603738
23	Pancreatic cysts (HP:0001737)	2.88469410
24	Abnormality of glycine metabolism (HP:0010895)	2.85147396
25	Abnormality of serine family amino acid metabolism (HP:0010894)	2.85147396
26	Pancreatic fibrosis (HP:0100732)	2.81668850
27	Respiratory difficulties (HP:0002880)	2.79819504
28	Sensorimotor neuropathy (HP:0007141)	2.74755180
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.66648450
30	Constricted visual fields (HP:0001133)	2.57841645
31	IgM deficiency (HP:0002850)	2.53895835
32	Carpal bone hypoplasia (HP:0001498)	2.51824183
33	IgG deficiency (HP:0004315)	2.50758121
34	Pendular nystagmus (HP:0012043)	2.50088327
35	Abnormal drinking behavior (HP:0030082)	2.48710278
36	Polydipsia (HP:0001959)	2.48710278
37	Generalized aminoaciduria (HP:0002909)	2.47509554
38	Molar tooth sign on MRI (HP:0002419)	2.44776317
39	Abnormality of midbrain morphology (HP:0002418)	2.44776317
40	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.43962742
41	Dicarboxylic aciduria (HP:0003215)	2.43962742
42	Congenital stationary night blindness (HP:0007642)	2.43536489
43	Abolished electroretinogram (ERG) (HP:0000550)	2.43427446
44	Nephronophthisis (HP:0000090)	2.42525530
45	Abnormality of the renal cortex (HP:0011035)	2.39333967
46	Renal Fanconi syndrome (HP:0001994)	2.31663707
47	Abnormality of macular pigmentation (HP:0008002)	2.25403881
48	Gonadotropin excess (HP:0000837)	2.22961009
49	Type I transferrin isoform profile (HP:0003642)	2.07496033
50	Asplenia (HP:0001746)	2.07137746
51	T lymphocytopenia (HP:0005403)	2.06315427
52	Abnormality of the prostate (HP:0008775)	2.05135786
53	Medial flaring of the eyebrow (HP:0010747)	2.04659346
54	Abnormality of T cell number (HP:0011839)	2.04165328
55	Abnormality of fatty-acid metabolism (HP:0004359)	2.03068049
56	Bifid tongue (HP:0010297)	2.01923580
57	IgA deficiency (HP:0002720)	2.01539909
58	Cerebellar dysplasia (HP:0007033)	2.01377866
59	Abnormality of the renal medulla (HP:0100957)	2.01359656
60	Tachypnea (HP:0002789)	2.01261525
61	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.01133514
62	Increased hepatocellular lipid droplets (HP:0006565)	1.97832666
63	Chronic sinusitis (HP:0011109)	1.97535722
64	Metabolic acidosis (HP:0001942)	1.97482651
65	Cystic liver disease (HP:0006706)	1.93411573
66	Abnormality of cochlea (HP:0000375)	1.92037900
67	Cerebral palsy (HP:0100021)	1.90790444
68	Hypoplasia of the thymus (HP:0000778)	1.88681717
69	Neoplasm of head and neck (HP:0012288)	1.85136460
70	Esophageal neoplasm (HP:0100751)	1.85136460
71	Increased corneal curvature (HP:0100692)	1.82106942
72	Keratoconus (HP:0000563)	1.82106942
73	Cerebral edema (HP:0002181)	1.74880328
74	Congenital primary aphakia (HP:0007707)	1.73277053
75	Prolonged neonatal jaundice (HP:0006579)	1.72552515
76	Abnormal spermatogenesis (HP:0008669)	1.72277367
77	Absent thumb (HP:0009777)	1.69439607
78	Glycosuria (HP:0003076)	1.68457133
79	Abnormality of urine glucose concentration (HP:0011016)	1.68457133
80	Lipid accumulation in hepatocytes (HP:0006561)	1.67666308
81	Hypoplasia of the pons (HP:0012110)	1.67114476
82	Acute encephalopathy (HP:0006846)	1.66470563
83	Squamous cell carcinoma (HP:0002860)	1.65714690
84	Morphological abnormality of the inner ear (HP:0011390)	1.65683149
85	Infertility (HP:0000789)	1.65450979
86	Thyroiditis (HP:0100646)	1.64440361
87	Methylmalonic acidemia (HP:0002912)	1.64310596
88	Recurrent sinusitis (HP:0011108)	1.63764403
89	Poor speech (HP:0002465)	1.63728554
90	Azoospermia (HP:0000027)	1.62812174
91	Stenosis of the external auditory canal (HP:0000402)	1.62635230
92	Gait imbalance (HP:0002141)	1.62238240
93	Polyuria (HP:0000103)	1.61098133
94	Abnormal biliary tract morphology (HP:0012440)	1.60592989
95	Onycholysis (HP:0001806)	1.60358212
96	Abnormality of the pons (HP:0007361)	1.59709749
97	Sclerocornea (HP:0000647)	1.58826036
98	Abnormality of eosinophils (HP:0001879)	1.58286155
99	Obstructive lung disease (HP:0006536)	1.57055449
100	Chronic obstructive pulmonary disease (HP:0006510)	1.57055449

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.75947249
2	CDK19	3.72317034
3	EIF2AK3	3.36444615
4	EIF2AK1	3.27741028
5	KIT	3.14167139
6	TXK	3.03183599
7	VRK2	2.72301971
8	NEK2	2.44025004
9	NUAK1	2.37635967
10	DAPK2	2.28758247
11	OXSR1	2.05491644
12	JAK3	1.94023447
13	MATK	1.92038953
14	MAP3K3	1.89494828
15	VRK1	1.73823257
16	PLK4	1.61570154
17	ADRBK2	1.55607749
18	MAP2K3	1.51895824
19	STK39	1.50569097
20	ZAK	1.50277469
21	GRK1	1.47128602
22	CCNB1	1.43156014
23	TLK1	1.42095436
24	TAF1	1.42054640
25	PLK2	1.41499079
26	FGFR2	1.31600611
27	MAPKAPK5	1.25543166
28	PRKCQ	1.22168740
29	TEC	1.22060412
30	NME1	1.21549263
31	DAPK1	1.20094251
32	FLT3	1.15887969
33	TNK2	1.10034328
34	PLK3	1.08164318
35	DAPK3	1.06526381
36	MARK3	1.01652030
37	PDK2	0.99216652
38	MAP3K13	0.99188418
39	BUB1	0.98616230
40	PRKG2	0.96867818
41	TTK	0.95684275
42	ITK	0.92107478
43	RPS6KB2	0.90507052
44	STK16	0.88207939
45	GRK5	0.86929385
46	CDC7	0.86812000
47	TRPM7	0.85807731
48	PLK1	0.84854874
49	PIK3CG	0.81964447
50	SMG1	0.80004509
51	RPS6KA6	0.75922536
52	PKN1	0.74042752
53	CAMK1D	0.72696969
54	INSRR	0.67929629
55	WNK4	0.67496811
56	TAOK3	0.66088489
57	RPS6KL1	0.65752999
58	RPS6KC1	0.65752999
59	RPS6KA5	0.63996804
60	BMPR1B	0.60549729
61	PINK1	0.57500590
62	RPS6KB1	0.57045112
63	ACVR1B	0.55871909
64	CSK	0.55506349
65	STK11	0.52621840
66	WNK3	0.49823216
67	ILK	0.49461360
68	PRKCE	0.49337817
69	PIM1	0.46207726
70	OBSCN	0.45152946
71	SYK	0.45081620
72	GRK7	0.44107625
73	MKNK1	0.42405412
74	PRKCI	0.42344527
75	RPS6KA1	0.42205280
76	CSNK2A2	0.40748917
77	PASK	0.39549823
78	LCK	0.39137506
79	PRKCZ	0.37947138
80	MUSK	0.37921325
81	PRKCD	0.36649740
82	PRKCA	0.36125227
83	MAPK13	0.35906838
84	CAMK1	0.35141954
85	ADRBK1	0.34182409
86	PRKACA	0.34040691
87	CSNK1A1L	0.33870840
88	CSNK1G3	0.33464443
89	MAP4K2	0.32846806
90	SRPK1	0.32762660
91	CHEK2	0.32650484
92	LYN	0.32303473
93	MAP2K6	0.31904768
94	PIK3CA	0.31671459
95	SGK2	0.30591967
96	LRRK2	0.29908684
97	KSR1	0.29701683
98	CSF1R	0.29168587
99	EIF2AK2	0.29114988
100	TBK1	0.27655068

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.82302529
2	Asthma_Homo sapiens_hsa05310	3.48312836
3	Linoleic acid metabolism_Homo sapiens_hsa00591	3.25272557
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.01360016
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.82366121
6	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.80151965
7	Ribosome_Homo sapiens_hsa03010	2.74263058
8	Allograft rejection_Homo sapiens_hsa05330	2.64302925
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.61979387
10	Fatty acid metabolism_Homo sapiens_hsa01212	2.44073384
11	Basal transcription factors_Homo sapiens_hsa03022	2.33963733
12	Fatty acid degradation_Homo sapiens_hsa00071	2.26315602
13	Graft-versus-host disease_Homo sapiens_hsa05332	2.25224928
14	Homologous recombination_Homo sapiens_hsa03440	2.19715923
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.13145896
16	Propanoate metabolism_Homo sapiens_hsa00640	2.08341211
17	Type I diabetes mellitus_Homo sapiens_hsa04940	2.03356469
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.90395562
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.85588960
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.70326824
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.68217009
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.66425011
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.58583524
24	Peroxisome_Homo sapiens_hsa04146	1.56080949
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.54666336
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.45678199
27	Olfactory transduction_Homo sapiens_hsa04740	1.36463098
28	Proteasome_Homo sapiens_hsa03050	1.35869284
29	Primary immunodeficiency_Homo sapiens_hsa05340	1.26986028
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.26667739
31	Fat digestion and absorption_Homo sapiens_hsa04975	1.24637736
32	Sulfur metabolism_Homo sapiens_hsa00920	1.22366158
33	Mismatch repair_Homo sapiens_hsa03430	1.21412096
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.19163237
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.14381792
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11998634
37	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.09035519
38	Parkinsons disease_Homo sapiens_hsa05012	1.01819608
39	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.01121989
40	Renin secretion_Homo sapiens_hsa04924	1.01109861
41	Oxidative phosphorylation_Homo sapiens_hsa00190	0.94139958
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.92836044
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.92024478
44	RNA degradation_Homo sapiens_hsa03018	0.91816752
45	p53 signaling pathway_Homo sapiens_hsa04115	0.88977124
46	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87020502
47	Phototransduction_Homo sapiens_hsa04744	0.86192020
48	RNA polymerase_Homo sapiens_hsa03020	0.84964628
49	Antigen processing and presentation_Homo sapiens_hsa04612	0.80731812
50	RNA transport_Homo sapiens_hsa03013	0.78582115
51	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.78359191
52	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.76302499
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.75654785
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.74792698
55	DNA replication_Homo sapiens_hsa03030	0.74541844
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71784190
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71754873
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66355463
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65063008
60	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.63931158
61	Salivary secretion_Homo sapiens_hsa04970	0.63877749
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63582475
63	One carbon pool by folate_Homo sapiens_hsa00670	0.63530377
64	Base excision repair_Homo sapiens_hsa03410	0.59351644
65	ABC transporters_Homo sapiens_hsa02010	0.58040401
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56139635
67	Purine metabolism_Homo sapiens_hsa00230	0.54343454
68	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53616365
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52394668
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52259213
71	Alzheimers disease_Homo sapiens_hsa05010	0.49367898
72	Fatty acid elongation_Homo sapiens_hsa00062	0.47452566
73	Long-term depression_Homo sapiens_hsa04730	0.45801211
74	Nicotine addiction_Homo sapiens_hsa05033	0.45711816
75	Caffeine metabolism_Homo sapiens_hsa00232	0.44721263
76	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.44602433
77	Metabolic pathways_Homo sapiens_hsa01100	0.44289308
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42714407
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42584853
80	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.42325055
81	Glutathione metabolism_Homo sapiens_hsa00480	0.42156082
82	Pentose phosphate pathway_Homo sapiens_hsa00030	0.41688782
83	Retinol metabolism_Homo sapiens_hsa00830	0.40391963
84	Protein export_Homo sapiens_hsa03060	0.37076883
85	Huntingtons disease_Homo sapiens_hsa05016	0.36750783
86	Circadian entrainment_Homo sapiens_hsa04713	0.35652763
87	Mineral absorption_Homo sapiens_hsa04978	0.33505669
88	Cardiac muscle contraction_Homo sapiens_hsa04260	0.31859736
89	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.30485333
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30453449
91	Gastric acid secretion_Homo sapiens_hsa04971	0.30408468
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30162293
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.26252238
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.25370206
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.25248797
96	Pancreatic secretion_Homo sapiens_hsa04972	0.24685498
97	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.22502824
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.22460922
99	Serotonergic synapse_Homo sapiens_hsa04726	0.21885807
100	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20967814

EEF1B2P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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