EEF1D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.91539631
2ribosomal small subunit assembly (GO:0000028)5.84202378
3translational termination (GO:0006415)5.75686370
4maturation of SSU-rRNA (GO:0030490)5.48706855
5ribosomal small subunit biogenesis (GO:0042274)5.39333864
6* translational elongation (GO:0006414)5.13180310
7ribosomal large subunit biogenesis (GO:0042273)5.08544867
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.90127686
9translational initiation (GO:0006413)4.85031537
10protein targeting to ER (GO:0045047)4.78912110
11cotranslational protein targeting to membrane (GO:0006613)4.78237258
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.71190233
13formation of translation preinitiation complex (GO:0001731)4.67260569
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55939972
15cellular protein complex disassembly (GO:0043624)4.52539979
16protein localization to endoplasmic reticulum (GO:0070972)4.47477700
17viral life cycle (GO:0019058)4.47119570
18DNA strand elongation involved in DNA replication (GO:0006271)4.29596391
19ribonucleoprotein complex biogenesis (GO:0022613)4.27278795
20telomere maintenance via semi-conservative replication (GO:0032201)4.08214251
21DNA strand elongation (GO:0022616)4.07375002
22protein complex disassembly (GO:0043241)4.07163370
23DNA replication initiation (GO:0006270)4.01794256
24DNA deamination (GO:0045006)3.99737673
25folic acid-containing compound biosynthetic process (GO:0009396)3.86468201
26DNA unwinding involved in DNA replication (GO:0006268)3.85867185
27macromolecular complex disassembly (GO:0032984)3.82829120
28DNA replication-dependent nucleosome assembly (GO:0006335)3.75346093
29DNA replication-dependent nucleosome organization (GO:0034723)3.75346093
30positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.75154828
31thymic T cell selection (GO:0045061)3.73582129
32nucleobase biosynthetic process (GO:0046112)3.73067616
33GDP-mannose metabolic process (GO:0019673)3.72000046
34protein localization to kinetochore (GO:0034501)3.70275919
35rRNA processing (GO:0006364)3.68453655
36* translation (GO:0006412)3.67423911
37ribosome biogenesis (GO:0042254)3.63716859
38ribosome assembly (GO:0042255)3.63364917
39IMP biosynthetic process (GO:0006188)3.60808696
40telomere maintenance via recombination (GO:0000722)3.60697847
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.59431367
42rRNA metabolic process (GO:0016072)3.57924323
43positive thymic T cell selection (GO:0045059)3.55881104
44mitotic nuclear envelope disassembly (GO:0007077)3.54508881
45mannose metabolic process (GO:0006013)3.50540400
46spliceosomal snRNP assembly (GO:0000387)3.47716274
47mitotic metaphase plate congression (GO:0007080)3.45314490
48DNA replication checkpoint (GO:0000076)3.44946346
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44748979
50mRNA catabolic process (GO:0006402)3.40651543
51purine nucleobase biosynthetic process (GO:0009113)3.39539644
52mitotic recombination (GO:0006312)3.39318574
53telomere maintenance via telomere lengthening (GO:0010833)3.37019040
54protein localization to chromosome, centromeric region (GO:0071459)3.34480288
55RNA catabolic process (GO:0006401)3.32790012
56membrane disassembly (GO:0030397)3.26796799
57nuclear envelope disassembly (GO:0051081)3.26796799
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26290408
59nuclear pore organization (GO:0006999)3.26270689
60antigen processing and presentation of endogenous antigen (GO:0019883)3.21903153
61IMP metabolic process (GO:0046040)3.21298648
62apoptotic process involved in morphogenesis (GO:0060561)3.20673539
63nucleotide-excision repair, DNA gap filling (GO:0006297)3.19712783
64negative regulation of erythrocyte differentiation (GO:0045647)3.19711797
65negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19216560
66chromatin remodeling at centromere (GO:0031055)3.17583778
67protein targeting to membrane (GO:0006612)3.13534494
68CENP-A containing nucleosome assembly (GO:0034080)3.12895242
69positive regulation of Cdc42 GTPase activity (GO:0043089)3.10820527
70positive regulation of gamma-delta T cell activation (GO:0046645)3.09314354
71proteasome assembly (GO:0043248)3.09131001
72cellular component biogenesis (GO:0044085)3.08454353
73spliceosomal complex assembly (GO:0000245)3.04289185
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.03969289
75pseudouridine synthesis (GO:0001522)3.03908346
76negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03702069
77NIK/NF-kappaB signaling (GO:0038061)3.03421650
78nuclear pore complex assembly (GO:0051292)3.01520473
793-UTR-mediated mRNA stabilization (GO:0070935)3.01100875
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00054815
81metaphase plate congression (GO:0051310)2.99617425
82positive regulation of keratinocyte differentiation (GO:0045618)2.99159746
83kinetochore organization (GO:0051383)2.97490710
84T cell selection (GO:0045058)2.95945895
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94591834
86spliceosomal tri-snRNP complex assembly (GO:0000244)2.93658837
87transcription-coupled nucleotide-excision repair (GO:0006283)2.92450810
88negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.91848562
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.90617433
90DNA replication-independent nucleosome organization (GO:0034724)2.89160845
91DNA replication-independent nucleosome assembly (GO:0006336)2.89160845
92pentose-phosphate shunt (GO:0006098)2.87446958
93negative regulation of cell size (GO:0045792)2.87217514
94negative thymic T cell selection (GO:0045060)2.87209558
95mitotic sister chromatid segregation (GO:0000070)2.86380831
96negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85955942
97negative regulation of ligase activity (GO:0051352)2.85955942
98negative T cell selection (GO:0043383)2.84066039
99modulation by virus of host process (GO:0019054)2.83502719
100rRNA modification (GO:0000154)2.82992574
101regulation of spindle organization (GO:0090224)2.82252712
102establishment of integrated proviral latency (GO:0075713)2.82081294
103regulation of gamma-delta T cell differentiation (GO:0045586)2.81687747
104negative regulation of cell killing (GO:0031342)2.80803191
105negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80803191
106histone exchange (GO:0043486)2.79330085
107pinocytosis (GO:0006907)2.77502476
108kinetochore assembly (GO:0051382)2.74473061
109transcription elongation from RNA polymerase III promoter (GO:0006385)2.74360454
110termination of RNA polymerase III transcription (GO:0006386)2.74360454
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74250307
112COPI coating of Golgi vesicle (GO:0048205)2.74198986
113Golgi transport vesicle coating (GO:0048200)2.74198986
114G1/S transition of mitotic cell cycle (GO:0000082)2.73886008
115cell cycle G1/S phase transition (GO:0044843)2.73886008
116regulation of gene silencing by RNA (GO:0060966)2.72806295
117regulation of posttranscriptional gene silencing (GO:0060147)2.72806295
118regulation of gene silencing by miRNA (GO:0060964)2.72806295
119modulation by symbiont of host cellular process (GO:0044068)2.72010928
120positive T cell selection (GO:0043368)2.70229462
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.70021258
122proline biosynthetic process (GO:0006561)2.69268009
123folic acid metabolic process (GO:0046655)2.68163061
124establishment of chromosome localization (GO:0051303)2.67705336
125RNA splicing, via transesterification reactions (GO:0000375)2.67323957
126RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66608340
127mRNA splicing, via spliceosome (GO:0000398)2.66608340
128ncRNA processing (GO:0034470)2.66303391
129DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.66005951
130attachment of spindle microtubules to kinetochore (GO:0008608)2.63888914
131chaperone-mediated protein complex assembly (GO:0051131)2.63455647
132signal transduction involved in DNA damage checkpoint (GO:0072422)2.62841610
133signal transduction involved in DNA integrity checkpoint (GO:0072401)2.62841610
134T cell apoptotic process (GO:0070231)2.62751867
135signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62033262
136intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62033262
137leukocyte aggregation (GO:0070486)2.61745229
138cellular response to interleukin-4 (GO:0071353)2.61693039
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60242546
140cellular response to virus (GO:0098586)2.59767890
141maternal placenta development (GO:0001893)2.59262543
142UV protection (GO:0009650)2.59209385
143cell-substrate adherens junction assembly (GO:0007045)2.58910032
144focal adhesion assembly (GO:0048041)2.58910032
145regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57825225
146activation of Rac GTPase activity (GO:0032863)2.57436699
147mature B cell differentiation involved in immune response (GO:0002313)2.53247664
148regulation of gamma-delta T cell activation (GO:0046643)2.47208619
149glucose catabolic process (GO:0006007)2.46468846
150embryonic process involved in female pregnancy (GO:0060136)2.40574548
151regulation of defense response to virus by virus (GO:0050690)2.40158090
152regulation of histone H3-K27 methylation (GO:0061085)2.40019028
153peptidyl-arginine omega-N-methylation (GO:0035247)2.39926796
154negative regulation of necroptotic process (GO:0060546)2.37769864
155response to interleukin-4 (GO:0070670)2.32781514
156adherens junction assembly (GO:0034333)2.32369869
157nucleobase-containing small molecule interconversion (GO:0015949)2.32141496
158protein retention in ER lumen (GO:0006621)2.29604387
159negative regulation of stress fiber assembly (GO:0051497)2.28327639
160NADPH regeneration (GO:0006740)2.26326230
161barbed-end actin filament capping (GO:0051016)2.24202744
162virion assembly (GO:0019068)2.23514997
163regulation of necroptotic process (GO:0060544)2.23168778
164pentose metabolic process (GO:0019321)2.22483540
165regulation of translational fidelity (GO:0006450)2.22406129
166response to muramyl dipeptide (GO:0032495)2.22259972
167regulation of glucose import in response to insulin stimulus (GO:2001273)2.21482716
168negative regulation of viral release from host cell (GO:1902187)2.18796665
169lymphocyte apoptotic process (GO:0070227)2.17818916
170regulation of necrotic cell death (GO:0010939)2.17176109
171modulation by symbiont of host defense response (GO:0052031)2.16787466
172modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.16787466
173positive regulation by organism of defense response of other organism involved in symbiotic interact2.16787466
174modulation by symbiont of host immune response (GO:0052553)2.16787466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93197464
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.58134453
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96916746
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.51905849
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30006344
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09827389
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93388015
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90978321
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.90727987
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88940713
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85511582
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.85145012
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.81803371
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74622151
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66470499
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51417235
17XRN2_22483619_ChIP-Seq_HELA_Human2.49054824
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29782980
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29647759
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.28159485
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27050199
22LXR_22292898_ChIP-Seq_THP-1_Human2.25966380
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.22012984
24VDR_23849224_ChIP-Seq_CD4+_Human2.07952620
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04182264
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02296608
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01891229
28DCP1A_22483619_ChIP-Seq_HELA_Human2.01313042
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96536400
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94842804
31RACK7_27058665_Chip-Seq_MCF-7_Human1.94527001
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88583300
33* TTF2_22483619_ChIP-Seq_HELA_Human1.88457577
34AR_21909140_ChIP-Seq_LNCAP_Human1.86317532
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84209734
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80231579
37* FOXP3_21729870_ChIP-Seq_TREG_Human1.80211613
38TCF7_22412390_ChIP-Seq_EML_Mouse1.79251316
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78531651
40MAF_26560356_Chip-Seq_TH1_Human1.76802432
41GABP_19822575_ChIP-Seq_HepG2_Human1.76281032
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75969716
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72570273
44KDM2B_26808549_Chip-Seq_DND41_Human1.72247738
45ZNF263_19887448_ChIP-Seq_K562_Human1.72011248
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70160188
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67864716
48MAF_26560356_Chip-Seq_TH2_Human1.67649162
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67041745
50UTX_26944678_Chip-Seq_JUKART_Human1.65311807
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64907460
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.64363298
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64291326
54VDR_24763502_ChIP-Seq_THP-1_Human1.63993927
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61171107
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60965960
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59784783
58ELK1_19687146_ChIP-ChIP_HELA_Human1.55508501
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.54802307
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50075787
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48984949
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.47376406
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.46305611
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45555086
65* P68_20966046_ChIP-Seq_HELA_Human1.44955712
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42367358
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42219100
68MYC_22102868_ChIP-Seq_BL_Human1.40042512
69KDM5A_27292631_Chip-Seq_BREAST_Human1.39777171
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39289327
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38844304
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35688306
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.35322675
74RUNX1_22412390_ChIP-Seq_EML_Mouse1.34674556
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31812626
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.31636910
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.31179096
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30930146
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29456341
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.29411182
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28652097
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27375622
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27173637
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26832803
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26560595
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.26463891
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24496988
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.24410910
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24216445
90* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24004357
91CIITA_25753668_ChIP-Seq_RAJI_Human1.23864908
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22984946
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22570800
94HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21955660
95* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21684484
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20433358
97* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20027800
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19313554
99* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18859842
100ATF3_27146783_Chip-Seq_COLON_Human1.18731632
101BCOR_27268052_Chip-Seq_Bcells_Human1.18643031
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18279743
103NCOR1_26117541_ChIP-Seq_K562_Human1.17691421
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17052884
105* SMC4_20622854_ChIP-Seq_HELA_Human1.16458131
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14039435
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.13383802
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13261672
109FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13115466
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12955779
111BCL6_27268052_Chip-Seq_Bcells_Human1.12639514
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12546176
113CTCF_26484167_Chip-Seq_Bcells_Mouse1.12156253
114E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11941343
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11840002
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11617682
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11484313
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10899850
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10027338
120ELK1_22589737_ChIP-Seq_MCF10A_Human1.09553541
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09544198
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.08863259
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08602532
124SPI1_23547873_ChIP-Seq_NB4_Human1.07502199
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07120592
126TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05252556
127TFEB_21752829_ChIP-Seq_HELA_Human1.04415953
128MYB_26560356_Chip-Seq_TH1_Human1.04025668
129CREB1_26743006_Chip-Seq_LNCaP_Human1.02460140
130BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02026537
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01762984
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01314740
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00929262
134* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00000490
135* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99799028
136ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99513311
137VDR_21846776_ChIP-Seq_THP-1_Human0.99026023
138CTCF_21964334_Chip-Seq_Bcells_Human0.99014376
139KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98983829
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98983829
141KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98983829
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96119941
143SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93505769
144RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92890974
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92180985
146SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91802125
147* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91524813
148MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91382972
149MYC_18940864_ChIP-ChIP_HL60_Human0.91072757
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90764379
151PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89228314
152NOTCH1_21737748_ChIP-Seq_TLL_Human0.88145811
153NANOG_21062744_ChIP-ChIP_HESCs_Human0.86274237
154CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85404973
155TP63_19390658_ChIP-ChIP_HaCaT_Human0.84364137
156SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81652184
157* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.81382842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57962861
2MP0004957_abnormal_blastocyst_morpholog4.09161204
3MP0003111_abnormal_nucleus_morphology3.83103623
4MP0010094_abnormal_chromosome_stability3.73900392
5MP0003077_abnormal_cell_cycle3.39320797
6MP0005451_abnormal_body_composition3.20751339
7MP0008057_abnormal_DNA_replication2.90228632
8MP0008058_abnormal_DNA_repair2.57232632
9MP0008932_abnormal_embryonic_tissue2.56667783
10MP0008007_abnormal_cellular_replicative2.51750994
11MP0003436_decreased_susceptibility_to2.49394466
12MP0005058_abnormal_lysosome_morphology2.32408423
13MP0010352_gastrointestinal_tract_polyps2.24002456
14MP0001730_embryonic_growth_arrest2.22164604
15MP0001873_stomach_inflammation2.21791112
16MP0010030_abnormal_orbit_morphology2.15144867
17MP0008260_abnormal_autophagy2.13501336
18MP0000350_abnormal_cell_proliferation1.93182178
19MP0003806_abnormal_nucleotide_metabolis1.92042688
20MP0004381_abnormal_hair_follicle1.89067019
21MP0003786_premature_aging1.89038394
22MP0000685_abnormal_immune_system1.88970031
23MP0004185_abnormal_adipocyte_glucose1.88685339
24MP0004947_skin_inflammation1.86494225
25MP0009840_abnormal_foam_cell1.76395056
26MP0003123_paternal_imprinting1.75013868
27MP0002396_abnormal_hematopoietic_system1.68125419
28MP0001849_ear_inflammation1.67079406
29MP0002877_abnormal_melanocyte_morpholog1.66299785
30MP0001835_abnormal_antigen_presentation1.65758004
31MP0009379_abnormal_foot_pigmentation1.65640443
32MP0003191_abnormal_cellular_cholesterol1.61994946
33MP0001697_abnormal_embryo_size1.59674172
34MP0001800_abnormal_humoral_immune1.59204104
35MP0001672_abnormal_embryogenesis/_devel1.57360036
36MP0005380_embryogenesis_phenotype1.57360036
37MP0005025_abnormal_response_to1.56418676
38MP0005000_abnormal_immune_tolerance1.53746639
39MP0003941_abnormal_skin_development1.51961691
40MP0002080_prenatal_lethality1.49866265
41MP0002420_abnormal_adaptive_immunity1.49227350
42MP0001819_abnormal_immune_cell1.48188299
43MP0000490_abnormal_crypts_of1.45880641
44MP0002085_abnormal_embryonic_tissue1.44541605
45MP0002723_abnormal_immune_serum1.42556068
46MP0005671_abnormal_response_to1.41858925
47MP0003984_embryonic_growth_retardation1.41013845
48MP0003718_maternal_effect1.40185868
49MP0010155_abnormal_intestine_physiology1.39622774
50MP0002088_abnormal_embryonic_growth/wei1.38212188
51MP0003705_abnormal_hypodermis_morpholog1.37467324
52MP0003567_abnormal_fetal_cardiomyocyte1.36348397
53MP0002452_abnormal_antigen_presenting1.35978471
54MP0004197_abnormal_fetal_growth/weight/1.35017672
55MP0002084_abnormal_developmental_patter1.34617537
56MP0005387_immune_system_phenotype1.33918960
57MP0001790_abnormal_immune_system1.33918960
58MP0010307_abnormal_tumor_latency1.33367113
59MP0000716_abnormal_immune_system1.31028423
60MP0005410_abnormal_fertilization1.30661334
61MP0010234_abnormal_vibrissa_follicle1.29327761
62MP0002086_abnormal_extraembryonic_tissu1.27708919
63MP0008877_abnormal_DNA_methylation1.27584161
64MP0009053_abnormal_anal_canal1.27493228
65MP0002419_abnormal_innate_immunity1.26135603
66MP0005023_abnormal_wound_healing1.25186991
67MP0002429_abnormal_blood_cell1.24953829
68MP0009333_abnormal_splenocyte_physiolog1.24105326
69MP0000313_abnormal_cell_death1.23972625
70MP0002019_abnormal_tumor_incidence1.23828778
71MP0001348_abnormal_lacrimal_gland1.23661158
72MP0004858_abnormal_nervous_system1.23061164
73MP0001853_heart_inflammation1.22079473
74MP0003300_gastrointestinal_ulcer1.21752946
75MP0001293_anophthalmia1.19996817
76MP0002210_abnormal_sex_determination1.19691899
77MP0004264_abnormal_extraembryonic_tissu1.19386944
78MP0002166_altered_tumor_susceptibility1.19220821
79MP0005666_abnormal_adipose_tissue1.17160735
80MP0003303_peritoneal_inflammation1.16963651
81MP0003866_abnormal_defecation1.16589559
82MP0000537_abnormal_urethra_morphology1.15599896
83MP0008438_abnormal_cutaneous_collagen1.15048890
84MP0002148_abnormal_hypersensitivity_rea1.14200709
85MP0003566_abnormal_cell_adhesion1.13635177
86MP0002405_respiratory_system_inflammati1.12115868
87MP0000750_abnormal_muscle_regeneration1.09417043
88MP0001929_abnormal_gametogenesis1.09337703
89MP0001145_abnormal_male_reproductive1.07378123
90MP0003315_abnormal_perineum_morphology1.07093932
91MP0005464_abnormal_platelet_physiology1.06766675
92MP0003186_abnormal_redox_activity1.06539150
93MP0002132_abnormal_respiratory_system1.06056327
94MP0004808_abnormal_hematopoietic_stem1.04474058
95MP0004133_heterotaxia1.04428247
96MP0009785_altered_susceptibility_to1.03702077
97MP0005501_abnormal_skin_physiology1.03544923
98MP0002111_abnormal_tail_morphology1.02761870
99MP0006054_spinal_hemorrhage1.00424017
100MP0005076_abnormal_cell_differentiation0.99808047
101MP0003091_abnormal_cell_migration0.97888787
102MP0001533_abnormal_skeleton_physiology0.97598074
103MP0002933_joint_inflammation0.97071420
104MP0000678_abnormal_parathyroid_gland0.95983836
105MP0005375_adipose_tissue_phenotype0.94435311
106MP0001845_abnormal_inflammatory_respons0.93226491
107MP0009931_abnormal_skin_appearance0.93023376
108MP0002160_abnormal_reproductive_system0.93009452
109MP0000759_abnormal_skeletal_muscle0.92864325
110MP0000358_abnormal_cell_content/0.91238665
111MP0001661_extended_life_span0.89240402
112MP0000653_abnormal_sex_gland0.87851779
113MP0000858_altered_metastatic_potential0.86608252
114MP0000703_abnormal_thymus_morphology0.86580013
115MP0000751_myopathy0.86269593
116MP0000747_muscle_weakness0.85276035
117MP0001545_abnormal_hematopoietic_system0.84662336
118MP0005397_hematopoietic_system_phenotyp0.84662336
119MP0002060_abnormal_skin_morphology0.84215606
120MP0003763_abnormal_thymus_physiology0.84149523
121MP0002998_abnormal_bone_remodeling0.83410037
122MP0003119_abnormal_digestive_system0.83121740
123MP0002796_impaired_skin_barrier0.81876157
124MP0005389_reproductive_system_phenotype0.81268465
125MP0005330_cardiomyopathy0.80665024
126MP0004510_myositis0.80451466
127MP0000003_abnormal_adipose_tissue0.80227008
128MP0005621_abnormal_cell_physiology0.79762695
129MP0004087_abnormal_muscle_fiber0.78103614
130MP0005083_abnormal_biliary_tract0.77838916
131MP0003937_abnormal_limbs/digits/tail_de0.77311824
132MP0002249_abnormal_larynx_morphology0.77119293
133MP0002722_abnormal_immune_system0.76257357
134MP0004233_abnormal_muscle_weight0.75536626
135MP0003890_abnormal_embryonic-extraembry0.75151805
136MP0003172_abnormal_lysosome_physiology0.75070526
137MP0000428_abnormal_craniofacial_morphol0.74573243
138MP0002282_abnormal_trachea_morphology0.71714998
139MP0005275_abnormal_skin_tensile0.70477995
140MP0001243_abnormal_dermal_layer0.70383096
141MP0000689_abnormal_spleen_morphology0.69023276
142MP0002398_abnormal_bone_marrow0.67478122
143MP0000049_abnormal_middle_ear0.67132101
144MP0006036_abnormal_mitochondrial_physio0.66833461
145MP0001919_abnormal_reproductive_system0.66557025
146MP0002092_abnormal_eye_morphology0.66177405
147MP0000733_abnormal_muscle_development0.66026051
148MP0003698_abnormal_male_reproductive0.65686497
149MP0009672_abnormal_birth_weight0.64323107
150MP0000762_abnormal_tongue_morphology0.64290363
151MP0001915_intracranial_hemorrhage0.63831387
152MP0002697_abnormal_eye_size0.63133933
153MP0009278_abnormal_bone_marrow0.62617545
154MP0000432_abnormal_head_morphology0.62051320
155MP0000477_abnormal_intestine_morphology0.61598127
156MP0001216_abnormal_epidermal_layer0.60789962
157MP0005384_cellular_phenotype0.60765193
158MP0003942_abnormal_urinary_system0.60633062
159MP0001286_abnormal_eye_development0.60507948
160MP0003453_abnormal_keratinocyte_physiol0.60478773
161MP0003221_abnormal_cardiomyocyte_apopto0.60439308
162MP0002932_abnormal_joint_morphology0.60349619

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.95185618
2Reticulocytopenia (HP:0001896)5.64900602
3Abnormal number of erythroid precursors (HP:0012131)5.32324317
4Macrocytic anemia (HP:0001972)4.29668130
5Pallor (HP:0000980)3.71751469
6Selective tooth agenesis (HP:0001592)3.63343337
7Birth length less than 3rd percentile (HP:0003561)3.62115582
8Breast hypoplasia (HP:0003187)3.43445811
9Oral leukoplakia (HP:0002745)3.37153751
10Trismus (HP:0000211)3.28459784
11Colitis (HP:0002583)3.21559302
12Colon cancer (HP:0003003)3.20785062
13Rough bone trabeculation (HP:0100670)3.13844255
14Distal lower limb muscle weakness (HP:0009053)3.11045951
15Centrally nucleated skeletal muscle fibers (HP:0003687)3.08507624
16Eczematoid dermatitis (HP:0000976)3.08289397
17Multiple enchondromatosis (HP:0005701)3.01223081
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01197179
19Absent thumb (HP:0009777)2.98620592
20Carpal bone hypoplasia (HP:0001498)2.87530042
2111 pairs of ribs (HP:0000878)2.75385705
22Abnormal hemoglobin (HP:0011902)2.72394834
23Vertebral compression fractures (HP:0002953)2.71710688
24Cerebral hypomyelination (HP:0006808)2.69931280
25Broad face (HP:0000283)2.69725073
26Increased connective tissue (HP:0009025)2.68446841
27Patellar aplasia (HP:0006443)2.66220125
28Hyperacusis (HP:0010780)2.65186656
29Aplastic anemia (HP:0001915)2.60221833
30Myopathic facies (HP:0002058)2.59598248
31Gastrointestinal inflammation (HP:0004386)2.59390610
32Degeneration of anterior horn cells (HP:0002398)2.58588394
33Abnormality of the anterior horn cell (HP:0006802)2.58588394
34Ragged-red muscle fibers (HP:0003200)2.55589243
35Aplasia/Hypoplasia of the patella (HP:0006498)2.52455002
36Cellulitis (HP:0100658)2.50311404
37Premature graying of hair (HP:0002216)2.50078816
38Absent radius (HP:0003974)2.43005348
39Distal lower limb amyotrophy (HP:0008944)2.42224403
40Achilles tendon contracture (HP:0001771)2.36606001
41Meckel diverticulum (HP:0002245)2.36147981
42Microretrognathia (HP:0000308)2.33660570
43Ulnar bowing (HP:0003031)2.33288837
44Neoplasm of the pancreas (HP:0002894)2.33099435
45Ependymoma (HP:0002888)2.32151555
46Abnormality of reticulocytes (HP:0004312)2.30738016
47Inflammation of the large intestine (HP:0002037)2.30292790
48Abnormality of the ileum (HP:0001549)2.29782038
49Abnormality of the preputium (HP:0100587)2.29081792
50Recurrent viral infections (HP:0004429)2.28860220
51Missing ribs (HP:0000921)2.27577167
52Increased IgE level (HP:0003212)2.25245821
53Abnormal trabecular bone morphology (HP:0100671)2.23961435
54Aplasia involving forearm bones (HP:0009822)2.22332782
55Absent forearm bone (HP:0003953)2.22332782
56Atresia of the external auditory canal (HP:0000413)2.20803175
57Elevated erythrocyte sedimentation rate (HP:0003565)2.20249641
58Abnormality of the umbilical cord (HP:0010881)2.20105734
59Secondary amenorrhea (HP:0000869)2.18570629
60Premature ovarian failure (HP:0008209)2.17791727
61Thrombocytosis (HP:0001894)2.16954371
62Hypoplasia of the radius (HP:0002984)2.12941637
63Triphalangeal thumb (HP:0001199)2.12822658
64Seborrheic dermatitis (HP:0001051)2.10741826
65Bulbar palsy (HP:0001283)2.10460914
66Progressive muscle weakness (HP:0003323)2.09166311
67Medulloblastoma (HP:0002885)2.08441096
68Chromsome breakage (HP:0040012)2.08420986
69Stenosis of the external auditory canal (HP:0000402)2.08224935
70Hypertensive crisis (HP:0100735)2.08137150
71Recurrent abscess formation (HP:0002722)2.08081774
72Agammaglobulinemia (HP:0004432)2.07835549
73Horseshoe kidney (HP:0000085)2.06319759
74Pustule (HP:0200039)2.06249750
75Glossoptosis (HP:0000162)2.05458780
76Abnormal number of incisors (HP:0011064)2.04592037
77Abnormality of the thoracic spine (HP:0100711)2.04521748
78Squamous cell carcinoma (HP:0002860)2.03815368
79Basal cell carcinoma (HP:0002671)2.03535441
80Impulsivity (HP:0100710)2.03351497
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02820465
82Chronic obstructive pulmonary disease (HP:0006510)2.01879934
83Obstructive lung disease (HP:0006536)2.01879934
84Abnormality of the Achilles tendon (HP:0005109)2.01715979
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99219344
86Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99219344
87Protrusio acetabuli (HP:0003179)1.98990273
88Sparse eyelashes (HP:0000653)1.98264897
89Myelodysplasia (HP:0002863)1.97523948
90Abnormality of the calcaneus (HP:0008364)1.97164557
91Abnormal lung lobation (HP:0002101)1.95695000
92Easy fatigability (HP:0003388)1.95680948
93Abnormality of chromosome stability (HP:0003220)1.95615204
94Cleft eyelid (HP:0000625)1.94878588
95Thoracic kyphosis (HP:0002942)1.94640839
96Broad distal phalanx of finger (HP:0009836)1.94483153
97Cerebral aneurysm (HP:0004944)1.94051309
98Gastrointestinal stroma tumor (HP:0100723)1.93797699
99Biconcave vertebral bodies (HP:0004586)1.93048377
100Exercise-induced myalgia (HP:0003738)1.92193232
101Interstitial pulmonary disease (HP:0006530)1.92064779
102Polygenic inheritance (HP:0010982)1.91903405
103Papilloma (HP:0012740)1.91769083
104Verrucae (HP:0200043)1.91769083
105Abnormality of the fingertips (HP:0001211)1.91565439
106Generalized amyotrophy (HP:0003700)1.91221465
107Recurrent bacterial skin infections (HP:0005406)1.91119748
108Recurrent fungal infections (HP:0002841)1.90740307
109Micronodular cirrhosis (HP:0001413)1.89408486
110Abnormality of skeletal muscle fiber size (HP:0012084)1.89026575
111Abnormality of the fetal cardiovascular system (HP:0010948)1.87881747
112Abnormal umbilical cord blood vessels (HP:0011403)1.87881747
113Single umbilical artery (HP:0001195)1.87881747
114Thin bony cortex (HP:0002753)1.87753334
115Aplasia/Hypoplasia of the uvula (HP:0010293)1.87189251
116Duodenal stenosis (HP:0100867)1.86904783
117Small intestinal stenosis (HP:0012848)1.86904783
118Aplasia/hypoplasia of the humerus (HP:0006507)1.86442113
119Syringomyelia (HP:0003396)1.85734077
120Spinal cord lesions (HP:0100561)1.85734077
121Mediastinal lymphadenopathy (HP:0100721)1.85598330
122Supernumerary spleens (HP:0009799)1.85580250
123Abnormality of macrophages (HP:0004311)1.85437202
124Increased serum ferritin (HP:0003281)1.84540757
125Rhabdomyosarcoma (HP:0002859)1.83707817
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83314253
127Ulnar deviation of the wrist (HP:0003049)1.83048026
128Cellular immunodeficiency (HP:0005374)1.82676730
129Tracheoesophageal fistula (HP:0002575)1.82151272
130Calcaneovalgus deformity (HP:0001848)1.81918198
131Flat acetabular roof (HP:0003180)1.81617865
132Bone marrow hypocellularity (HP:0005528)1.80603808
133Long palpebral fissure (HP:0000637)1.79631013
134Asplenia (HP:0001746)1.79249112
135Pancytopenia (HP:0001876)1.79137501
136Difficulty climbing stairs (HP:0003551)1.78953238
137Meningitis (HP:0001287)1.78741598
138Microvesicular hepatic steatosis (HP:0001414)1.78408968
139Premature rupture of membranes (HP:0001788)1.78172308
140Stridor (HP:0010307)1.77947954
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77066469
142Increased variability in muscle fiber diameter (HP:0003557)1.76777298
143Elbow flexion contracture (HP:0002987)1.75099196
144Dislocated radial head (HP:0003083)1.74514535
145Progressive external ophthalmoplegia (HP:0000590)1.73645763
146Depressed nasal ridge (HP:0000457)1.73038113
147Premature skin wrinkling (HP:0100678)1.73016184
148Asymmetry of the thorax (HP:0001555)1.72650158
149Proximal placement of thumb (HP:0009623)1.72522004
150IgM deficiency (HP:0002850)1.72125163
151Deviation of the thumb (HP:0009603)1.70872709
152Granulocytopenia (HP:0001913)1.70668291
153Panhypogammaglobulinemia (HP:0003139)1.70293072
154Abnormality of the columella (HP:0009929)1.69897625
155Disproportionate tall stature (HP:0001519)1.69766416
156Slender long bone (HP:0003100)1.69347784
157Cervical subluxation (HP:0003308)1.69096907
158Osteolytic defects of the hand bones (HP:0009699)1.67080037
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.67080037
160Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66781693
161Congenital, generalized hypertrichosis (HP:0004540)1.66738851
162Fragile skin (HP:0001030)1.66661746
163Abnormality of the radial head (HP:0003995)1.66421019
164Aplasia/Hypoplasia of the spleen (HP:0010451)1.65986161
165Facial cleft (HP:0002006)1.65645269
166Gastrointestinal dysmotility (HP:0002579)1.65613984
167Sloping forehead (HP:0000340)1.65073054
168Abnormality of oral frenula (HP:0000190)1.64919709
169Viral hepatitis (HP:0006562)1.64233035
170Hypertriglyceridemia (HP:0002155)1.63413162
171Emphysema (HP:0002097)1.63358096
172Entropion (HP:0000621)1.63311013
173Megaloblastic anemia (HP:0001889)1.62546882
174Aplasia/Hypoplasia of the thymus (HP:0010515)1.62425026
175Ureteral duplication (HP:0000073)1.62223394
176Duplicated collecting system (HP:0000081)1.61982163
177Deformed tarsal bones (HP:0008119)1.61626024
178Testicular atrophy (HP:0000029)1.61458513
179Short thumb (HP:0009778)1.60692493
180Sparse lateral eyebrow (HP:0005338)1.60658782
181Abdominal situs inversus (HP:0003363)1.60417040
182Abnormality of abdominal situs (HP:0011620)1.60417040
183Fatigue (HP:0012378)1.59828042
184Abnormality of T cells (HP:0002843)1.59729554
185Agnosia (HP:0010524)1.58745375
186Breech presentation (HP:0001623)1.57741684

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.63075893
2WEE13.78864669
3EIF2AK13.42557700
4SMG13.27833680
5NME23.20857972
6CDC73.09021888
7PRPF4B2.61178028
8TLK12.60024907
9SIK12.55032609
10ERN12.49587627
11TESK22.37878550
12IRAK32.30586899
13NEK22.16603224
14TESK12.16487868
15SRPK12.14132137
16RPS6KB22.06072648
17TTK1.95950367
18TSSK61.87557697
19EIF2AK31.70859546
20PLK41.69705397
21PASK1.68474604
22PLK11.68080070
23NEK11.65698028
24BRSK21.63522532
25EPHA21.61491496
26STK161.61365717
27CDK71.60699844
28AURKB1.58239414
29STK101.52993446
30VRK21.47929742
31EEF2K1.46674767
32MKNK11.46097118
33VRK11.43742628
34LRRK21.37848274
35RPS6KA41.37203773
36MAP3K81.36522716
37DYRK31.36048265
38TBK11.35512032
39PIM21.33799557
40GRK61.32847990
41FGFR41.27809488
42AURKA1.26654703
43PAK41.26434756
44ATR1.26023869
45MST1R1.23342374
46MAP3K131.22577261
47ARAF1.20610327
48ACVR1B1.19994921
49TGFBR11.19235551
50ZAK1.17183393
51IRAK41.13281253
52CHEK21.09208682
53MAP3K111.08191458
54PTK61.05545996
55BCKDK1.05501633
56TYK21.00836843
57CDK41.00569261
58CHEK10.99014456
59PLK30.98144139
60BRSK10.97633154
61SCYL20.97371515
62PDK40.94591370
63PDK30.94591370
64MAPK110.94224656
65BTK0.94208478
66MAP3K100.90741992
67PKN20.90518344
68MKNK20.89817165
69PAK10.89191472
70ILK0.88996546
71PBK0.88053528
72CDK120.87817187
73STK40.86868171
74RIPK10.86371560
75KDR0.85744057
76PIM10.83721239
77FLT30.83342933
78MAPKAPK30.83032070
79MAP3K10.82768149
80RIPK40.79111205
81LIMK10.78683930
82MST40.78469003
83IKBKE0.76662383
84PDPK10.75737434
85IRAK20.75235790
86MAP3K140.75150641
87CSNK2A20.73829480
88MARK30.73096627
89TTN0.71204246
90EPHB10.71138393
91JAK30.70914233
92ALK0.70287687
93SIK30.67136121
94CDK20.66912336
95CSK0.66630412
96ATM0.66023767
97MARK20.65916663
98IKBKB0.65742465
99MAP3K30.65622256
100MUSK0.65365168
101TNK20.64575926
102PAK20.64431009
103* CSNK2A10.63938077
104MAP2K30.63843988
105PRKD20.63678464
106FES0.62711077
107HIPK20.62547184
108CDC42BPA0.61759102
109CDK80.61515745
110MAP4K10.60602784
111ICK0.60111689
112RPS6KA50.59139641
113BRAF0.57566741
114PDK20.57258850
115NME10.57161840
116PRKCI0.56792013
117RPS6KA60.55630867
118EIF2AK20.55018552
119STK38L0.54995339
120CDK60.53832363
121MAPK120.53553471
122TRIB30.53242190
123CSF1R0.52426131
124LATS20.51571722
125RPS6KA20.51386044
126TAOK10.48772040
127HCK0.47230093
128MELK0.46405845
129MTOR0.45845446
130SIK20.45232568
131MAP3K60.45038622
132PDK10.44386339
133ITK0.43932945
134PDGFRA0.42354004
135STK30.40328439
136* CDK10.40236236
137LCK0.39662123
138MAP2K20.39521450
139BMX0.38558896
140RPS6KA10.36556580
141BLK0.35646883
142DYRK1B0.35372039
143TAOK20.34947105
144MET0.33696143
145MOS0.33522810
146NEK90.31621721
147MAPKAPK20.31540530
148AKT20.31270999
149ZAP700.31127327
150RPS6KC10.31038349
151RPS6KL10.31038349
152CSNK1E0.31028538
153PNCK0.29963741

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.96609162
2DNA replication_Homo sapiens_hsa030304.47401757
3Mismatch repair_Homo sapiens_hsa034303.81707557
4Proteasome_Homo sapiens_hsa030503.46219996
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.42277254
6RNA polymerase_Homo sapiens_hsa030203.21997396
7Spliceosome_Homo sapiens_hsa030403.16277812
8RNA transport_Homo sapiens_hsa030132.88577151
9One carbon pool by folate_Homo sapiens_hsa006702.73977943
10Base excision repair_Homo sapiens_hsa034102.72051678
11Homologous recombination_Homo sapiens_hsa034402.66617256
12Nucleotide excision repair_Homo sapiens_hsa034202.64979837
13Other glycan degradation_Homo sapiens_hsa005112.54880618
14Pyrimidine metabolism_Homo sapiens_hsa002402.39402927
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34868305
16Cell cycle_Homo sapiens_hsa041102.18983571
17B cell receptor signaling pathway_Homo sapiens_hsa046621.87902127
18Fanconi anemia pathway_Homo sapiens_hsa034601.84404429
19Chronic myeloid leukemia_Homo sapiens_hsa052201.76334469
20Non-small cell lung cancer_Homo sapiens_hsa052231.72453793
21Basal transcription factors_Homo sapiens_hsa030221.65659278
22RNA degradation_Homo sapiens_hsa030181.64134819
23Non-homologous end-joining_Homo sapiens_hsa034501.61300428
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54553046
25T cell receptor signaling pathway_Homo sapiens_hsa046601.54510784
26p53 signaling pathway_Homo sapiens_hsa041151.46463816
27VEGF signaling pathway_Homo sapiens_hsa043701.45294120
28mRNA surveillance pathway_Homo sapiens_hsa030151.41016295
29Pancreatic cancer_Homo sapiens_hsa052121.36804489
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27153417
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26084080
32Osteoclast differentiation_Homo sapiens_hsa043801.25360980
33Purine metabolism_Homo sapiens_hsa002301.22472172
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21253564
35Systemic lupus erythematosus_Homo sapiens_hsa053221.21075995
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.20809630
37Leishmaniasis_Homo sapiens_hsa051401.17164481
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17148337
39Influenza A_Homo sapiens_hsa051641.11820051
40Epstein-Barr virus infection_Homo sapiens_hsa051691.10212107
41Protein export_Homo sapiens_hsa030601.09968606
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05938485
43Endometrial cancer_Homo sapiens_hsa052131.05045671
44Allograft rejection_Homo sapiens_hsa053301.04490699
45Hepatitis C_Homo sapiens_hsa051601.04324066
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03915784
47Biosynthesis of amino acids_Homo sapiens_hsa012301.01648959
48Folate biosynthesis_Homo sapiens_hsa007901.01392234
49Toxoplasmosis_Homo sapiens_hsa051451.00416145
50Autoimmune thyroid disease_Homo sapiens_hsa053201.00119985
51Sulfur relay system_Homo sapiens_hsa041220.99551222
52Graft-versus-host disease_Homo sapiens_hsa053320.98813472
53Antigen processing and presentation_Homo sapiens_hsa046120.98173888
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94558374
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.89984030
56TNF signaling pathway_Homo sapiens_hsa046680.89893639
57Pentose phosphate pathway_Homo sapiens_hsa000300.89686642
58Glutathione metabolism_Homo sapiens_hsa004800.89672574
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.89629245
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.89627047
61Huntingtons disease_Homo sapiens_hsa050160.88164465
62Viral carcinogenesis_Homo sapiens_hsa052030.86319666
63mTOR signaling pathway_Homo sapiens_hsa041500.86258330
64Selenocompound metabolism_Homo sapiens_hsa004500.85752529
65Parkinsons disease_Homo sapiens_hsa050120.84701503
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.84071956
67Insulin signaling pathway_Homo sapiens_hsa049100.78925355
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76824587
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74857092
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73906724
71Prion diseases_Homo sapiens_hsa050200.73774420
72Renal cell carcinoma_Homo sapiens_hsa052110.73671210
73Colorectal cancer_Homo sapiens_hsa052100.72089389
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71998146
75Carbon metabolism_Homo sapiens_hsa012000.71826415
76Prostate cancer_Homo sapiens_hsa052150.70678712
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68950377
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68940134
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.67568749
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67216278
81HTLV-I infection_Homo sapiens_hsa051660.67209849
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66965915
83* Herpes simplex infection_Homo sapiens_hsa051680.66585959
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66303948
85Hematopoietic cell lineage_Homo sapiens_hsa046400.65945666
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64580912
87Tuberculosis_Homo sapiens_hsa051520.63281672
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.63191900
89Endocytosis_Homo sapiens_hsa041440.62780600
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.62299517
91Oxidative phosphorylation_Homo sapiens_hsa001900.61696076
92Insulin resistance_Homo sapiens_hsa049310.61434177
93Small cell lung cancer_Homo sapiens_hsa052220.59185887
94Salmonella infection_Homo sapiens_hsa051320.57885065
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57884073
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57072478
97Glioma_Homo sapiens_hsa052140.56271197
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55661101
99Oocyte meiosis_Homo sapiens_hsa041140.55442136
100Legionellosis_Homo sapiens_hsa051340.55042318
101ErbB signaling pathway_Homo sapiens_hsa040120.54688850
102Proteoglycans in cancer_Homo sapiens_hsa052050.54307764
103Vitamin B6 metabolism_Homo sapiens_hsa007500.53873781
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53710662
105Malaria_Homo sapiens_hsa051440.51800257
106Basal cell carcinoma_Homo sapiens_hsa052170.49208150
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.49047094
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48584312
109Prolactin signaling pathway_Homo sapiens_hsa049170.48316523
110MicroRNAs in cancer_Homo sapiens_hsa052060.47105894
111Focal adhesion_Homo sapiens_hsa045100.47099310
112Choline metabolism in cancer_Homo sapiens_hsa052310.46975532
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45757968
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45311566
115Fructose and mannose metabolism_Homo sapiens_hsa000510.45294534
116TGF-beta signaling pathway_Homo sapiens_hsa043500.44825061
117Lysosome_Homo sapiens_hsa041420.44715032
118Hippo signaling pathway_Homo sapiens_hsa043900.44448532
119Bladder cancer_Homo sapiens_hsa052190.43281677
120Thyroid cancer_Homo sapiens_hsa052160.42386932
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42268720
122Arachidonic acid metabolism_Homo sapiens_hsa005900.41956682
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40674970
124Apoptosis_Homo sapiens_hsa042100.39821176
125Primary immunodeficiency_Homo sapiens_hsa053400.38768531
126Linoleic acid metabolism_Homo sapiens_hsa005910.33919698
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33239268
128Hedgehog signaling pathway_Homo sapiens_hsa043400.32834991
129Arginine and proline metabolism_Homo sapiens_hsa003300.32759916
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32475984
131Metabolic pathways_Homo sapiens_hsa011000.32095453
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31168564
133HIF-1 signaling pathway_Homo sapiens_hsa040660.30147425
134Galactose metabolism_Homo sapiens_hsa000520.29967287
135Notch signaling pathway_Homo sapiens_hsa043300.29437668
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.26673503
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26400033
138N-Glycan biosynthesis_Homo sapiens_hsa005100.25361059
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.24726561
140Shigellosis_Homo sapiens_hsa051310.22845771
141Measles_Homo sapiens_hsa051620.21558713
142Alcoholism_Homo sapiens_hsa050340.21395400
143Alzheimers disease_Homo sapiens_hsa050100.21235180
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19650834
145Pyruvate metabolism_Homo sapiens_hsa006200.18910364
146Viral myocarditis_Homo sapiens_hsa054160.18843034
147Tight junction_Homo sapiens_hsa045300.18575051
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17771530
149Acute myeloid leukemia_Homo sapiens_hsa052210.17139252
150Adherens junction_Homo sapiens_hsa045200.17136148
151Pathways in cancer_Homo sapiens_hsa052000.16911900
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15896948
153NF-kappa B signaling pathway_Homo sapiens_hsa040640.14773765
154Hepatitis B_Homo sapiens_hsa051610.13334834
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12428841

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