ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.26889335
2	DNA deamination (GO:0045006)	6.05963708
3	ribosomal small subunit assembly (GO:0000028)	5.80389583
4	viral transcription (GO:0019083)	5.37283277
5	translational termination (GO:0006415)	5.17286312
6	cytidine metabolic process (GO:0046087)	5.01580926
7	cytidine catabolic process (GO:0006216)	5.01580926
8	cytidine deamination (GO:0009972)	5.01580926
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.72743385
10	protein targeting to ER (GO:0045047)	4.67409579
11	cotranslational protein targeting to membrane (GO:0006613)	4.67374876
12	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.65536442
13	translational elongation (GO:0006414)	4.58630405
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.50785180
15	protein localization to endoplasmic reticulum (GO:0070972)	4.40183424
16	maturation of SSU-rRNA (GO:0030490)	4.27171982
17	negative regulation by host of viral transcription (GO:0043922)	4.11434938
18	ATP synthesis coupled proton transport (GO:0015986)	4.07708270
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.07708270
20	positive regulation of prostaglandin secretion (GO:0032308)	4.03232190
21	ribosomal small subunit biogenesis (GO:0042274)	3.96861359
22	cellular protein complex disassembly (GO:0043624)	3.91140486
23	viral life cycle (GO:0019058)	3.90158764
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.78707856
25	behavioral response to nicotine (GO:0035095)	3.77788215
26	protein neddylation (GO:0045116)	3.76737605
27	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.71037146
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.70828722
29	cellular response to interleukin-15 (GO:0071350)	3.62877413
30	mannosylation (GO:0097502)	3.62427911
31	activated T cell proliferation (GO:0050798)	3.56990622
32	regulation of chronic inflammatory response (GO:0002676)	3.49105307
33	translational initiation (GO:0006413)	3.43198562
34	regulation of isotype switching to IgG isotypes (GO:0048302)	3.41697344
35	negative regulation of telomere maintenance (GO:0032205)	3.39827656
36	negative regulation of execution phase of apoptosis (GO:1900118)	3.35101095
37	positive regulation of defense response to virus by host (GO:0002230)	3.32589307
38	respiratory electron transport chain (GO:0022904)	3.29822091
39	electron transport chain (GO:0022900)	3.28561887
40	T cell migration (GO:0072678)	3.27933522
41	negative regulation of T cell apoptotic process (GO:0070233)	3.20037022
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.20015842
43	positive regulation of calcium-mediated signaling (GO:0050850)	3.19327361
44	regulation of regulatory T cell differentiation (GO:0045589)	3.14863212
45	protein complex disassembly (GO:0043241)	3.14112583
46	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.12986680
47	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.12878467
48	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.11060306
49	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.10971176
50	sequestering of actin monomers (GO:0042989)	3.08055095
51	translation (GO:0006412)	3.07588351
52	macromolecular complex disassembly (GO:0032984)	3.06870615
53	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.06613214
54	regulation of immunoglobulin secretion (GO:0051023)	3.00431297
55	positive regulation of fatty acid transport (GO:2000193)	2.97514452
56	proteasome assembly (GO:0043248)	2.91677523
57	protein targeting to membrane (GO:0006612)	2.91592976
58	water-soluble vitamin biosynthetic process (GO:0042364)	2.91215922
59	regulation of prostaglandin secretion (GO:0032306)	2.90701209
60	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.88730449
61	metallo-sulfur cluster assembly (GO:0031163)	2.87318743
62	iron-sulfur cluster assembly (GO:0016226)	2.87318743
63	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.86464475
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.86229443
65	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.84761701
66	positive regulation of interleukin-8 secretion (GO:2000484)	2.83057515
67	positive regulation of cell killing (GO:0031343)	2.81173720
68	hydrogen ion transmembrane transport (GO:1902600)	2.80767179
69	mRNA catabolic process (GO:0006402)	2.79921366
70	positive regulation of icosanoid secretion (GO:0032305)	2.78555391
71	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78408654
72	actin nucleation (GO:0045010)	2.78244106
73	protein-cofactor linkage (GO:0018065)	2.77814327
74	peptidyl-histidine modification (GO:0018202)	2.74209071
75	cytolysis (GO:0019835)	2.72654136
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.72393633
77	termination of RNA polymerase III transcription (GO:0006386)	2.72393633
78	proton transport (GO:0015992)	2.70008553
79	negative T cell selection (GO:0043383)	2.69258429
80	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.68774535
81	protein complex biogenesis (GO:0070271)	2.67355305
82	positive regulation of T cell cytokine production (GO:0002726)	2.67204139
83	sulfation (GO:0051923)	2.65823552
84	GPI anchor metabolic process (GO:0006505)	2.65638258
85	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.64296219
86	hydrogen transport (GO:0006818)	2.63469295
87	GPI anchor biosynthetic process (GO:0006506)	2.63373062
88	chaperone-mediated protein transport (GO:0072321)	2.62332140
89	regulation of leukocyte mediated cytotoxicity (GO:0001910)	2.61348023
90	ribosomal large subunit biogenesis (GO:0042273)	2.61267851
91	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.60841863
92	regulation of meiosis I (GO:0060631)	2.59249035
93	response to interleukin-15 (GO:0070672)	2.58433003
94	indolalkylamine metabolic process (GO:0006586)	2.58376063
95	negative thymic T cell selection (GO:0045060)	2.57367821
96	endoderm formation (GO:0001706)	2.55498815
97	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.54357561
98	regulation of alpha-beta T cell proliferation (GO:0046640)	2.54119643
99	positive regulation of tolerance induction (GO:0002645)	2.51770594
100	cellular ketone body metabolic process (GO:0046950)	2.49292868

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.63203042
2	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.69822027
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.59036928
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.54493167
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.29588994
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.27061055
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.81686765
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80139726
9	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.77080215
10	VDR_22108803_ChIP-Seq_LS180_Human	2.69574587
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.66569516
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.64789551
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.42403671
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.35309219
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30011427
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.19619333
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.17996664
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.14963534
19	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.02055735
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.00492662
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83724055
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.79735805
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.76619764
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.67234398
25	GATA3_26560356_Chip-Seq_TH2_Human	1.57032773
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56554887
27	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.55545565
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52673219
29	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.49438914
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.48773017
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.47272326
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.45155629
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.44990355
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.43586600
35	RUNX_20019798_ChIP-Seq_JUKART_Human	1.42857009
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.42437501
37	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.41770544
38	AR_20517297_ChIP-Seq_VCAP_Human	1.37371732
39	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.36858824
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35829488
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.33682149
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31148598
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.27633641
44	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.27170376
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.26783300
46	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24732192
47	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.24658328
48	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23525428
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23525428
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22722618
51	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.20330200
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17828008
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.16936807
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.16571788
55	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.15580421
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15309802
57	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15297491
58	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14827339
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.13973431
60	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13536167
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.13001744
62	ERA_21632823_ChIP-Seq_H3396_Human	1.11849632
63	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.11615057
64	MYB_26560356_Chip-Seq_TH2_Human	1.09525320
65	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08760210
66	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05664571
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04072288
68	GBX2_23144817_ChIP-Seq_PC3_Human	1.03090857
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02629331
70	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01680423
71	EWS_26573619_Chip-Seq_HEK293_Human	1.01482406
72	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.00731312
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.98449367
74	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98348020
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97238041
76	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.95908819
77	P300_27268052_Chip-Seq_Bcells_Human	0.95857324
78	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95565421
79	CTCF_20526341_ChIP-Seq_ESCs_Human	0.95396399
80	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.93899280
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.93831537
82	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93074019
83	BCL6_27268052_Chip-Seq_Bcells_Human	0.93067388
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.93029768
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93003131
86	GATA3_27048872_Chip-Seq_THYMUS_Human	0.92755690
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.91653476
88	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.90037562
89	NCOR_22424771_ChIP-Seq_293T_Human	0.89717267
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.89121515
91	MYC_19829295_ChIP-Seq_ESCs_Human	0.88804232
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88201621
93	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.87767905
94	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.86686368
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.85884563
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.85715150
97	P300_19829295_ChIP-Seq_ESCs_Human	0.84294551
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.83205362
99	CBP_20019798_ChIP-Seq_JUKART_Human	0.83037006
100	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.83037006

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.79716748
2	MP0009379_abnormal_foot_pigmentation	3.50648412
3	MP0002277_abnormal_respiratory_mucosa	2.94478852
4	MP0000569_abnormal_digit_pigmentation	2.90962098
5	MP0003011_delayed_dark_adaptation	2.53151960
6	MP0005646_abnormal_pituitary_gland	2.32569259
7	MP0009785_altered_susceptibility_to	2.19974054
8	MP0005645_abnormal_hypothalamus_physiol	2.14426451
9	MP0002148_abnormal_hypersensitivity_rea	2.04737515
10	MP0002876_abnormal_thyroid_physiology	2.04387026
11	MP0003763_abnormal_thymus_physiology	2.00546703
12	MP0002138_abnormal_hepatobiliary_system	1.89877882
13	MP0006292_abnormal_olfactory_placode	1.86289984
14	MP0000685_abnormal_immune_system	1.81387151
15	MP0004742_abnormal_vestibular_system	1.80548375
16	MP0002736_abnormal_nociception_after	1.79333684
17	MP0001968_abnormal_touch/_nociception	1.78495559
18	MP0009333_abnormal_splenocyte_physiolog	1.72903174
19	MP0002653_abnormal_ependyma_morphology	1.66556855
20	MP0002095_abnormal_skin_pigmentation	1.65622367
21	MP0008877_abnormal_DNA_methylation	1.64399491
22	MP0001800_abnormal_humoral_immune	1.64115062
23	MP0003436_decreased_susceptibility_to	1.63151050
24	MP0000566_synostosis	1.62660482
25	MP0005000_abnormal_immune_tolerance	1.62089570
26	MP0006072_abnormal_retinal_apoptosis	1.55245412
27	MP0000372_irregular_coat_pigmentation	1.54435901
28	MP0003724_increased_susceptibility_to	1.53122381
29	MP0003878_abnormal_ear_physiology	1.44002892
30	MP0005377_hearing/vestibular/ear_phenot	1.44002892
31	MP0005551_abnormal_eye_electrophysiolog	1.43760612
32	MP0001790_abnormal_immune_system	1.42758522
33	MP0005387_immune_system_phenotype	1.42758522
34	MP0002420_abnormal_adaptive_immunity	1.40826713
35	MP0002723_abnormal_immune_serum	1.40028977
36	MP0001819_abnormal_immune_cell	1.38015904
37	MP0003866_abnormal_defecation	1.37507156
38	MP0008789_abnormal_olfactory_epithelium	1.36046426
39	MP0008875_abnormal_xenobiotic_pharmacok	1.35393143
40	MP0000613_abnormal_salivary_gland	1.32293064
41	MP0005075_abnormal_melanosome_morpholog	1.31478135
42	MP0004885_abnormal_endolymph	1.29682589
43	MP0001835_abnormal_antigen_presentation	1.27358430
44	MP0002938_white_spotting	1.26918822
45	MP0001986_abnormal_taste_sensitivity	1.25707134
46	MP0008872_abnormal_physiological_respon	1.20553316
47	MP0003880_abnormal_central_pattern	1.19701322
48	MP0005174_abnormal_tail_pigmentation	1.18597649
49	MP0003195_calcinosis	1.18448552
50	MP0005025_abnormal_response_to	1.16761842
51	MP0001501_abnormal_sleep_pattern	1.16469057
52	MP0001905_abnormal_dopamine_level	1.15858416
53	MP0002452_abnormal_antigen_presenting	1.13612605
54	MP0001984_abnormal_olfaction	1.13499785
55	MP0002282_abnormal_trachea_morphology	1.13179973
56	MP0003183_abnormal_peptide_metabolism	1.12178338
57	MP0001873_stomach_inflammation	1.10729408
58	MP0008995_early_reproductive_senescence	1.10617779
59	MP0004145_abnormal_muscle_electrophysio	1.10552366
60	MP0000631_abnormal_neuroendocrine_gland	1.09668461
61	MP0002405_respiratory_system_inflammati	1.09022480
62	MP0005253_abnormal_eye_physiology	1.00076106
63	MP0003136_yellow_coat_color	0.99650224
64	MP0003045_fibrosis	0.98462220
65	MP0004147_increased_porphyrin_level	0.98340755
66	MP0000716_abnormal_immune_system	0.98226322
67	MP0001881_abnormal_mammary_gland	0.96368237
68	MP0001485_abnormal_pinna_reflex	0.95927453
69	MP0009745_abnormal_behavioral_response	0.94158618
70	MP0001346_abnormal_lacrimal_gland	0.91215500
71	MP0001188_hyperpigmentation	0.90068627
72	MP0002102_abnormal_ear_morphology	0.89412989
73	MP0000703_abnormal_thymus_morphology	0.87394033
74	MP0003787_abnormal_imprinting	0.87181451
75	MP0002638_abnormal_pupillary_reflex	0.85057337
76	MP0002163_abnormal_gland_morphology	0.84143842
77	MP0002398_abnormal_bone_marrow	0.84093396
78	MP0009764_decreased_sensitivity_to	0.83761497
79	MP0000647_abnormal_sebaceous_gland	0.83748502
80	MP0001764_abnormal_homeostasis	0.83541791
81	MP0005084_abnormal_gallbladder_morpholo	0.82789739
82	MP0002272_abnormal_nervous_system	0.80799384
83	MP0001529_abnormal_vocalization	0.79698406
84	MP0005636_abnormal_mineral_homeostasis	0.79525105
85	MP0008058_abnormal_DNA_repair	0.79267706
86	MP0000639_abnormal_adrenal_gland	0.79246155
87	MP0010155_abnormal_intestine_physiology	0.79157016
88	MP0000049_abnormal_middle_ear	0.78531459
89	MP0003786_premature_aging	0.77763298
90	MP0003938_abnormal_ear_development	0.76816523
91	MP0001845_abnormal_inflammatory_respons	0.76013967
92	MP0004381_abnormal_hair_follicle	0.75640482
93	MP0001533_abnormal_skeleton_physiology	0.75021937
94	MP0001765_abnormal_ion_homeostasis	0.74595873
95	MP0005410_abnormal_fertilization	0.74218410
96	MP0001919_abnormal_reproductive_system	0.73586667
97	MP0005389_reproductive_system_phenotype	0.69802039
98	MP0002928_abnormal_bile_duct	0.69791716
99	MP0000689_abnormal_spleen_morphology	0.68966743
100	MP0003936_abnormal_reproductive_system	0.68955927

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.19867206
2	Aplastic anemia (HP:0001915)	3.87885808
3	Acute necrotizing encephalopathy (HP:0006965)	3.86285594
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.63006661
5	Mitochondrial inheritance (HP:0001427)	3.47526259
6	Elevated erythrocyte sedimentation rate (HP:0003565)	3.43386584
7	IgG deficiency (HP:0004315)	3.37265148
8	Reticulocytopenia (HP:0001896)	3.16022909
9	T lymphocytopenia (HP:0005403)	3.15188148
10	Autoimmune hemolytic anemia (HP:0001890)	3.11395019
11	Severe combined immunodeficiency (HP:0004430)	3.05935933
12	Progressive macrocephaly (HP:0004481)	3.04890947
13	Congenital stationary night blindness (HP:0007642)	3.01789721
14	Septo-optic dysplasia (HP:0100842)	3.01641243
15	Concave nail (HP:0001598)	2.99314191
16	Abnormality of cells of the erythroid lineage (HP:0012130)	2.97140678
17	Acute encephalopathy (HP:0006846)	2.93214528
18	Cerebellar dysplasia (HP:0007033)	2.91909725
19	3-Methylglutaconic aciduria (HP:0003535)	2.89952896
20	Increased CSF lactate (HP:0002490)	2.89855234
21	Abnormality of T cell number (HP:0011839)	2.83499014
22	Retinal dysplasia (HP:0007973)	2.81472949
23	Abnormal number of erythroid precursors (HP:0012131)	2.75601809
24	Congenital, generalized hypertrichosis (HP:0004540)	2.75310996
25	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.74357705
26	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.66127433
27	Macrocytic anemia (HP:0001972)	2.60840398
28	Abolished electroretinogram (ERG) (HP:0000550)	2.56512766
29	Pancreatic fibrosis (HP:0100732)	2.54490081
30	Pancreatic cysts (HP:0001737)	2.54018184
31	Abnormality of T cells (HP:0002843)	2.53914734
32	Pancytopenia (HP:0001876)	2.53536342
33	Colon cancer (HP:0003003)	2.51011454
34	Renal Fanconi syndrome (HP:0001994)	2.48396289
35	Increased hepatocellular lipid droplets (HP:0006565)	2.47917327
36	Abnormality of midbrain morphology (HP:0002418)	2.44670575
37	Molar tooth sign on MRI (HP:0002419)	2.44670575
38	Hepatocellular necrosis (HP:0001404)	2.44283472
39	Hypoproteinemia (HP:0003075)	2.43950401
40	Cerebral edema (HP:0002181)	2.43535869
41	Thyroiditis (HP:0100646)	2.39415885
42	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.37755206
43	Nephronophthisis (HP:0000090)	2.37526275
44	Abnormality of the renal cortex (HP:0011035)	2.37133382
45	Increased intramyocellular lipid droplets (HP:0012240)	2.36510803
46	Renal cortical cysts (HP:0000803)	2.34831929
47	Optic disc pallor (HP:0000543)	2.33552447
48	Recurrent bronchitis (HP:0002837)	2.30113693
49	Testicular atrophy (HP:0000029)	2.27548155
50	Hypoplasia of the pons (HP:0012110)	2.27445872
51	Recurrent cutaneous fungal infections (HP:0011370)	2.23988133
52	Chronic mucocutaneous candidiasis (HP:0002728)	2.23988133
53	Humeroradial synostosis (HP:0003041)	2.23603682
54	Synostosis involving the elbow (HP:0003938)	2.23603682
55	Combined immunodeficiency (HP:0005387)	2.23143390
56	Lissencephaly (HP:0001339)	2.22050708
57	Hepatic necrosis (HP:0002605)	2.21777655
58	True hermaphroditism (HP:0010459)	2.19573041
59	Stomatitis (HP:0010280)	2.18705481
60	Autoimmune thrombocytopenia (HP:0001973)	2.16294816
61	Abnormality of the pons (HP:0007361)	2.16134628
62	Visual hallucinations (HP:0002367)	2.14673700
63	Methylmalonic acidemia (HP:0002912)	2.14343344
64	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08397845
65	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08397845
66	Rib fusion (HP:0000902)	2.07475664
67	Prostate neoplasm (HP:0100787)	2.02475185
68	Lipid accumulation in hepatocytes (HP:0006561)	1.98674448
69	Abnormality of the renal medulla (HP:0100957)	1.97840428
70	Abnormality of eosinophils (HP:0001879)	1.97376484
71	Pallor (HP:0000980)	1.94466043
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92973432
73	Aplasia/hypoplasia of the uterus (HP:0008684)	1.92076920
74	Increased serum lactate (HP:0002151)	1.91615214
75	Infantile muscular hypotonia (HP:0008947)	1.91597220
76	Flat capital femoral epiphysis (HP:0003370)	1.91408696
77	Abnormality of alanine metabolism (HP:0010916)	1.90750446
78	Hyperalaninemia (HP:0003348)	1.90750446
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.90750446
80	Lactic acidosis (HP:0003128)	1.89857248
81	Maternal diabetes (HP:0009800)	1.89199778
82	Increased cerebral lipofuscin (HP:0011813)	1.88784112
83	Lethargy (HP:0001254)	1.88339322
84	Chronic hepatic failure (HP:0100626)	1.88129779
85	Lymphopenia (HP:0001888)	1.87679485
86	Bronchitis (HP:0012387)	1.87085835
87	Tubular atrophy (HP:0000092)	1.84925399
88	Parakeratosis (HP:0001036)	1.83126395
89	Dyschromatopsia (HP:0007641)	1.81801870
90	Optic nerve hypoplasia (HP:0000609)	1.78334361
91	B lymphocytopenia (HP:0010976)	1.77420902
92	Methylmalonic aciduria (HP:0012120)	1.77188423
93	Conical tooth (HP:0000698)	1.76643987
94	Absent septum pellucidum (HP:0001331)	1.76492897
95	Opisthotonus (HP:0002179)	1.76220347
96	Absent thumb (HP:0009777)	1.76158616
97	Increased muscle lipid content (HP:0009058)	1.76106284
98	Severe muscular hypotonia (HP:0006829)	1.76005051
99	Bile duct proliferation (HP:0001408)	1.75739635
100	Abnormal biliary tract physiology (HP:0012439)	1.75739635

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.98516361
2	TESK2	4.68778868
3	MAP4K2	3.96958798
4	BCKDK	2.84373623
5	MAP4K1	2.79350431
6	ZAK	2.78559433
7	TLK1	2.74953584
8	KDR	2.74513667
9	VRK2	2.73995915
10	MUSK	2.59980895
11	ADRBK2	2.42211300
12	TESK1	2.00969297
13	VRK1	1.96372770
14	PNCK	1.91963498
15	GRK1	1.82030634
16	ITK	1.68176175
17	IKBKE	1.64213607
18	WNK3	1.46325446
19	CAMKK2	1.44397626
20	WNK4	1.43974275
21	LRRK2	1.39793097
22	NUAK1	1.37283925
23	TNK2	1.34159010
24	GRK6	1.28983816
25	IKBKB	1.21531903
26	LIMK1	1.18912875
27	PIK3CA	1.14682903
28	PRKCQ	1.14670119
29	IRAK4	1.14040744
30	PINK1	1.13684766
31	FES	1.11187888
32	TBK1	1.03570615
33	AKT3	1.01861068
34	MAP3K4	1.01671635
35	DYRK2	0.99851586
36	MAP2K6	0.99575715
37	PASK	0.99347977
38	BTK	0.97791484
39	TIE1	0.96841734
40	TEC	0.93608389
41	STK39	0.91802338
42	ADRBK1	0.91347741
43	PAK3	0.90217121
44	CDK8	0.86777849
45	MAPKAPK3	0.85747565
46	NME1	0.84892729
47	PIK3CG	0.84347503
48	MST4	0.83884873
49	IRAK2	0.83537424
50	WEE1	0.80431364
51	SYK	0.79945251
52	MAP2K7	0.78725648
53	MAP3K11	0.77562121
54	LCK	0.76416939
55	CSK	0.76229522
56	SIK2	0.74154449
57	BUB1	0.73348068
58	INSRR	0.67960891
59	MAP2K2	0.66288785
60	MAPK13	0.65260915
61	CDK19	0.64270862
62	EPHB2	0.64063986
63	LYN	0.60309155
64	PDK2	0.59834325
65	NME2	0.59387737
66	GRK7	0.57488597
67	FRK	0.57165665
68	CAMK1	0.54818623
69	BMPR2	0.50288552
70	IGF1R	0.50196832
71	AURKA	0.48136857
72	CSNK2A2	0.45741400
73	BRSK2	0.43483697
74	NTRK2	0.42443494
75	KIT	0.42079759
76	PRKACA	0.41543550
77	PRKCG	0.41364503
78	MAPK15	0.39620850
79	STK16	0.37539295
80	PLK4	0.36601338
81	TAOK3	0.35675735
82	OBSCN	0.35099114
83	BRSK1	0.34946254
84	PIM1	0.34892350
85	MAP3K12	0.34534295
86	CHUK	0.33052196
87	CSNK2A1	0.32579144
88	CSNK1A1	0.32568577
89	CAMK2A	0.32478072
90	RPS6KA5	0.32038220
91	PRKCA	0.30481118
92	TRIM28	0.30206623
93	CAMKK1	0.28470535
94	OXSR1	0.28016495
95	MAP3K14	0.26603337
96	ATR	0.25054735
97	AURKB	0.23402036
98	CSNK1E	0.22526862
99	SRPK1	0.22414641
100	EIF2AK2	0.21978505

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.64021294
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.01296486
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.85753728
4	Proteasome_Homo sapiens_hsa03050	3.19691266
5	Parkinsons disease_Homo sapiens_hsa05012	3.03298914
6	RNA polymerase_Homo sapiens_hsa03020	2.58532636
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.18025104
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.14485560
9	Protein export_Homo sapiens_hsa03060	2.13685211
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.11795580
11	Alzheimers disease_Homo sapiens_hsa05010	2.10791048
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.08628308
13	Huntingtons disease_Homo sapiens_hsa05016	1.92156343
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.87418172
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.86768795
16	Phototransduction_Homo sapiens_hsa04744	1.82227286
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.75082170
18	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.72827202
19	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.68966928
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.64379104
21	Homologous recombination_Homo sapiens_hsa03440	1.60682351
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.39680429
23	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.39416746
24	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.39189418
25	Allograft rejection_Homo sapiens_hsa05330	1.39131531
26	RNA degradation_Homo sapiens_hsa03018	1.35370153
27	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32588525
28	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.31718132
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.31227925
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30321293
31	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.28111038
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.27212473
33	Caffeine metabolism_Homo sapiens_hsa00232	1.26974157
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.25446397
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.24510240
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24234380
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.22573983
38	Sulfur metabolism_Homo sapiens_hsa00920	1.20903889
39	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18562628
40	Sulfur relay system_Homo sapiens_hsa04122	1.16603436
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14818687
42	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13603955
43	Basal transcription factors_Homo sapiens_hsa03022	1.12663815
44	Rheumatoid arthritis_Homo sapiens_hsa05323	1.09799641
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09416609
46	Mismatch repair_Homo sapiens_hsa03430	1.05469938
47	Peroxisome_Homo sapiens_hsa04146	1.04558051
48	Nucleotide excision repair_Homo sapiens_hsa03420	1.02873992
49	Butanoate metabolism_Homo sapiens_hsa00650	0.99245657
50	Steroid biosynthesis_Homo sapiens_hsa00100	0.94720148
51	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.94180248
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93722051
53	One carbon pool by folate_Homo sapiens_hsa00670	0.91814206
54	Purine metabolism_Homo sapiens_hsa00230	0.89286285
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.87918753
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84723132
57	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83387809
58	Measles_Homo sapiens_hsa05162	0.74538504
59	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72845312
60	Propanoate metabolism_Homo sapiens_hsa00640	0.68256870
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.67190892
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63809582
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.60252202
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.59095701
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58579368
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.56547494
67	Metabolic pathways_Homo sapiens_hsa01100	0.56329496
68	Retinol metabolism_Homo sapiens_hsa00830	0.56131894
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55930837
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53462948
71	Asthma_Homo sapiens_hsa05310	0.52112768
72	Nicotine addiction_Homo sapiens_hsa05033	0.51193056
73	Spliceosome_Homo sapiens_hsa03040	0.50542826
74	Olfactory transduction_Homo sapiens_hsa04740	0.47938491
75	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46950299
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.46217640
77	Taste transduction_Homo sapiens_hsa04742	0.45188890
78	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.44641869
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.44034443
80	Phenylalanine metabolism_Homo sapiens_hsa00360	0.43886026
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.42756040
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42423931
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41683168
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.41480483
85	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.38661101
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34909157
87	DNA replication_Homo sapiens_hsa03030	0.33640157
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.30367378
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29784517
90	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29751760
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.29316243
92	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.29135513
93	ABC transporters_Homo sapiens_hsa02010	0.28675386
94	RNA transport_Homo sapiens_hsa03013	0.28248638
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.26147005
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.24921424
97	beta-Alanine metabolism_Homo sapiens_hsa00410	0.24753332
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.23118035
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.20921495
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.17893044

EEF1DP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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