ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	5.64644807
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.64644807
3	spinal cord association neuron differentiation (GO:0021527)	5.64605359
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.50397799
5	sequestering of actin monomers (GO:0042989)	5.16360677
6	pyrimidine nucleobase catabolic process (GO:0006208)	4.92393278
7	behavioral response to nicotine (GO:0035095)	4.45868386
8	protein neddylation (GO:0045116)	4.25718106
9	neuronal action potential propagation (GO:0019227)	4.19903447
10	respiratory electron transport chain (GO:0022904)	4.02532092
11	cellular response to ATP (GO:0071318)	4.01210527
12	electron transport chain (GO:0022900)	3.99094200
13	regulation of action potential (GO:0098900)	3.97707413
14	response to pheromone (GO:0019236)	3.86596980
15	nucleobase catabolic process (GO:0046113)	3.84946501
16	cell differentiation in spinal cord (GO:0021515)	3.73624595
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.73082226
18	neuron fate specification (GO:0048665)	3.71856755
19	C4-dicarboxylate transport (GO:0015740)	3.67047914
20	motor neuron axon guidance (GO:0008045)	3.36101766
21	platelet dense granule organization (GO:0060155)	3.34825832
22	DNA double-strand break processing (GO:0000729)	3.23831898
23	protein complex biogenesis (GO:0070271)	3.23235577
24	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23010218
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23010218
26	NADH dehydrogenase complex assembly (GO:0010257)	3.23010218
27	pituitary gland development (GO:0021983)	3.20853583
28	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.19629140
29	protein localization to synapse (GO:0035418)	3.17545385
30	negative regulation of calcium ion transport into cytosol (GO:0010523)	3.17033307
31	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.12683772
32	hydrogen ion transmembrane transport (GO:1902600)	3.09740968
33	transmission of nerve impulse (GO:0019226)	3.08846849
34	ribosomal small subunit assembly (GO:0000028)	3.00466775
35	regulation of synapse structural plasticity (GO:0051823)	3.00282654
36	nonmotile primary cilium assembly (GO:0035058)	3.00121338
37	retinal ganglion cell axon guidance (GO:0031290)	2.96301997
38	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91205026
39	hindbrain development (GO:0030902)	2.88246426
40	proton transport (GO:0015992)	2.86340492
41	synaptic transmission, cholinergic (GO:0007271)	2.84300209
42	ATP biosynthetic process (GO:0006754)	2.84135133
43	hydrogen transport (GO:0006818)	2.81994933
44	establishment of mitochondrion localization (GO:0051654)	2.81497914
45	protein localization to cilium (GO:0061512)	2.79329830
46	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.79029287
47	negative regulation of multicellular organism growth (GO:0040015)	2.78929247
48	neuron cell-cell adhesion (GO:0007158)	2.78419121
49	ubiquinone metabolic process (GO:0006743)	2.78316251
50	negative regulation of heart rate (GO:0010459)	2.77013213
51	base-excision repair, AP site formation (GO:0006285)	2.76591120
52	limb development (GO:0060173)	2.76097422
53	appendage development (GO:0048736)	2.76097422
54	central nervous system projection neuron axonogenesis (GO:0021952)	2.74382226
55	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.73859589
56	positive regulation of cAMP-mediated signaling (GO:0043950)	2.72858259
57	post-embryonic morphogenesis (GO:0009886)	2.71643576
58	protein-cofactor linkage (GO:0018065)	2.71244491
59	regulation of transmission of nerve impulse (GO:0051969)	2.70142396
60	detection of light stimulus involved in visual perception (GO:0050908)	2.67641765
61	detection of light stimulus involved in sensory perception (GO:0050962)	2.67641765
62	ubiquinone biosynthetic process (GO:0006744)	2.66119556
63	negative regulation of microtubule polymerization (GO:0031115)	2.64683731
64	multicellular organism reproduction (GO:0032504)	2.63957052
65	regulation of dopamine secretion (GO:0014059)	2.63676660
66	placenta development (GO:0001890)	2.63595876
67	spinal cord motor neuron differentiation (GO:0021522)	2.63509966
68	chaperone-mediated protein transport (GO:0072321)	2.62128981
69	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.61772372
70	regulation of respiratory system process (GO:0044065)	2.61360175
71	synaptic transmission, glutamatergic (GO:0035249)	2.58494480
72	spinal cord development (GO:0021510)	2.57804148
73	positive regulation of synapse assembly (GO:0051965)	2.57046215
74	epithelial cilium movement (GO:0003351)	2.55728866
75	regulation of respiratory gaseous exchange (GO:0043576)	2.55261085
76	neuron recognition (GO:0008038)	2.53674653
77	protein K11-linked deubiquitination (GO:0035871)	2.53343973
78	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.52918592
79	regulation of feeding behavior (GO:0060259)	2.52702179
80	negative regulation of mast cell activation (GO:0033004)	2.52551132
81	limb bud formation (GO:0060174)	2.50512143
82	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.50055910
83	presynaptic membrane assembly (GO:0097105)	2.49942263
84	sulfation (GO:0051923)	2.48509703
85	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47737114
86	oxidative phosphorylation (GO:0006119)	2.47476309
87	regulation of microtubule-based movement (GO:0060632)	2.46831759
88	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.44231513
89	anterograde synaptic vesicle transport (GO:0048490)	2.43660131
90	regulation of protein kinase A signaling (GO:0010738)	2.43350065
91	autophagic vacuole fusion (GO:0000046)	2.42423475
92	photoreceptor cell development (GO:0042461)	2.41379279
93	protein peptidyl-prolyl isomerization (GO:0000413)	2.40029794
94	motile cilium assembly (GO:0044458)	2.38811535
95	presynaptic membrane organization (GO:0097090)	2.37509727
96	response to redox state (GO:0051775)	2.36243500
97	negative regulation of telomere maintenance (GO:0032205)	2.35661308
98	isoprenoid biosynthetic process (GO:0008299)	2.35400593
99	neurotransmitter-gated ion channel clustering (GO:0072578)	2.35368105
100	cilium morphogenesis (GO:0060271)	2.34037716

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.99451615
2	VDR_22108803_ChIP-Seq_LS180_Human	4.09360403
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.45020692
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.28242463
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.98802005
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.87928286
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.84148782
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.74358981
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.51880986
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.38736968
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.36933278
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.34626714
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22707295
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.14848536
15	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.13663979
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08786060
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.99027333
18	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.95027127
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92593954
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.89059835
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.83413104
22	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.80011936
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.77008065
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72262386
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.66858315
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66841247
27	EWS_26573619_Chip-Seq_HEK293_Human	1.64497836
28	P300_19829295_ChIP-Seq_ESCs_Human	1.63182627
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62979997
30	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.60696740
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56153375
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.54953118
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.54815670
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.53904242
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.53440531
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50604085
37	FUS_26573619_Chip-Seq_HEK293_Human	1.49078444
38	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.45369158
39	HTT_18923047_ChIP-ChIP_STHdh_Human	1.44555582
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42736700
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.41265844
42	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.39149680
43	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.37625190
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.36897400
45	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.36644342
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35705456
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34527039
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.34527039
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.33786481
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32113700
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.29890804
52	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.27097625
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24961711
54	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.24416885
55	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.23376560
56	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.23138984
57	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.20164883
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18893090
59	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.16278262
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.16075285
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.15503100
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14702989
63	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13363386
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13077415
65	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08491496
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.08059001
67	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.07271266
68	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.07195425
69	SMAD4_21799915_ChIP-Seq_A2780_Human	1.07070064
70	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.06560170
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.04115125
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03187164
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03187164
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03157611
75	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.03119754
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.01558452
77	VDR_23849224_ChIP-Seq_CD4+_Human	1.01249356
78	NCOR_22424771_ChIP-Seq_293T_Human	1.01117792
79	ELK1_19687146_ChIP-ChIP_HELA_Human	1.00942519
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99962197
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99103383
82	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.99027524
83	MYC_18940864_ChIP-ChIP_HL60_Human	0.97405940
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97072223
85	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96088763
86	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.95047699
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94180313
88	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.93970653
89	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.93970653
90	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.92592126
91	AR_25329375_ChIP-Seq_VCAP_Human	0.92110524
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91876256
93	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.91714243
94	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.90324970
95	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88751137
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.87479199
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.87479199
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86932856
99	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.86791351
100	DROSHA_22980978_ChIP-Seq_HELA_Human	0.86623914

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.21700309
2	MP0001986_abnormal_taste_sensitivity	4.29583028
3	MP0003787_abnormal_imprinting	3.62867040
4	MP0003123_paternal_imprinting	3.62186683
5	MP0003122_maternal_imprinting	2.99029921
6	MP0001968_abnormal_touch/_nociception	2.59298610
7	MP0005423_abnormal_somatic_nervous	2.43065700
8	MP0003121_genomic_imprinting	2.24246011
9	MP0003880_abnormal_central_pattern	2.18399992
10	MP0002638_abnormal_pupillary_reflex	2.15161409
11	MP0003136_yellow_coat_color	2.11940538
12	MP0008872_abnormal_physiological_respon	2.11891607
13	MP0002938_white_spotting	2.05177157
14	MP0008877_abnormal_DNA_methylation	2.02018436
15	MP0002102_abnormal_ear_morphology	1.95799283
16	MP0002736_abnormal_nociception_after	1.91172464
17	MP0005551_abnormal_eye_electrophysiolog	1.83323430
18	MP0005174_abnormal_tail_pigmentation	1.82179239
19	MP0006276_abnormal_autonomic_nervous	1.78035599
20	MP0000631_abnormal_neuroendocrine_gland	1.77671761
21	MP0009745_abnormal_behavioral_response	1.74485904
22	MP0002735_abnormal_chemical_nociception	1.73462832
23	MP0001984_abnormal_olfaction	1.72556389
24	MP0001905_abnormal_dopamine_level	1.71377305
25	MP0002272_abnormal_nervous_system	1.71260756
26	MP0002822_catalepsy	1.66495266
27	MP0009046_muscle_twitch	1.60868518
28	MP0001529_abnormal_vocalization	1.56042275
29	MP0002837_dystrophic_cardiac_calcinosis	1.50011285
30	MP0004742_abnormal_vestibular_system	1.49281272
31	MP0000778_abnormal_nervous_system	1.47454777
32	MP0002734_abnormal_mechanical_nocicepti	1.47028977
33	MP0003635_abnormal_synaptic_transmissio	1.45155109
34	MP0001970_abnormal_pain_threshold	1.43403627
35	MP0005084_abnormal_gallbladder_morpholo	1.42886251
36	MP0003011_delayed_dark_adaptation	1.42648649
37	MP0006292_abnormal_olfactory_placode	1.40128075
38	MP0002067_abnormal_sensory_capabilities	1.38067317
39	MP0002572_abnormal_emotion/affect_behav	1.33940284
40	MP0001188_hyperpigmentation	1.32058267
41	MP0001502_abnormal_circadian_rhythm	1.31699905
42	MP0003646_muscle_fatigue	1.31283110
43	MP0002064_seizures	1.30724715
44	MP0005253_abnormal_eye_physiology	1.28105852
45	MP0005075_abnormal_melanosome_morpholog	1.26942201
46	MP0002063_abnormal_learning/memory/cond	1.26282450
47	MP0002184_abnormal_innervation	1.25472262
48	MP0002733_abnormal_thermal_nociception	1.24464386
49	MP0005386_behavior/neurological_phenoty	1.22208081
50	MP0004924_abnormal_behavior	1.22208081
51	MP0000566_synostosis	1.21452602
52	MP0008875_abnormal_xenobiotic_pharmacok	1.20919131
53	MP0008789_abnormal_olfactory_epithelium	1.20276445
54	MP0002653_abnormal_ependyma_morphology	1.19574308
55	MP0001486_abnormal_startle_reflex	1.18805229
56	MP0005499_abnormal_olfactory_system	1.18004652
57	MP0005394_taste/olfaction_phenotype	1.18004652
58	MP0000427_abnormal_hair_cycle	1.17189605
59	MP0005646_abnormal_pituitary_gland	1.13244191
60	MP0006072_abnormal_retinal_apoptosis	1.11439691
61	MP0005645_abnormal_hypothalamus_physiol	1.10522212
62	MP0002095_abnormal_skin_pigmentation	1.07492794
63	MP0004885_abnormal_endolymph	1.04293360
64	MP0002557_abnormal_social/conspecific_i	1.03610181
65	MP0000639_abnormal_adrenal_gland	1.01607566
66	MP0002752_abnormal_somatic_nervous	1.01464386
67	MP0005083_abnormal_biliary_tract	0.99441823
68	MP0000049_abnormal_middle_ear	0.96779710
69	MP0008775_abnormal_heart_ventricle	0.96257669
70	MP0005670_abnormal_white_adipose	0.95979446
71	MP0000955_abnormal_spinal_cord	0.94222696
72	MP0005171_absent_coat_pigmentation	0.93095308
73	MP0003938_abnormal_ear_development	0.91711462
74	MP0002751_abnormal_autonomic_nervous	0.91323068
75	MP0004270_analgesia	0.90628645
76	MP0002882_abnormal_neuron_morphology	0.88430975
77	MP0001440_abnormal_grooming_behavior	0.88161814
78	MP0002234_abnormal_pharynx_morphology	0.87612339
79	MP0001293_anophthalmia	0.87282020
80	MP0000026_abnormal_inner_ear	0.86808674
81	MP0004859_abnormal_synaptic_plasticity	0.86401624
82	MP0003937_abnormal_limbs/digits/tail_de	0.86239959
83	MP0001485_abnormal_pinna_reflex	0.85549400
84	MP0009379_abnormal_foot_pigmentation	0.82962883
85	MP0003119_abnormal_digestive_system	0.81793546
86	MP0001324_abnormal_eye_pigmentation	0.78126027
87	MP0005391_vision/eye_phenotype	0.76062075
88	MP0005195_abnormal_posterior_eye	0.75654089
89	MP0002160_abnormal_reproductive_system	0.74775390
90	MP0004142_abnormal_muscle_tone	0.74030558
91	MP0002132_abnormal_respiratory_system	0.73426171
92	MP0005187_abnormal_penis_morphology	0.73328048
93	MP0010386_abnormal_urinary_bladder	0.70497299
94	MP0006036_abnormal_mitochondrial_physio	0.69359475
95	MP0002282_abnormal_trachea_morphology	0.69078969
96	MP0003567_abnormal_fetal_cardiomyocyte	0.68194768
97	MP0004130_abnormal_muscle_cell	0.68138315
98	MP0006035_abnormal_mitochondrial_morpho	0.67407490
99	MP0000372_irregular_coat_pigmentation	0.66799795
100	MP0003890_abnormal_embryonic-extraembry	0.66356297

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	7.97928225
2	Optic nerve hypoplasia (HP:0000609)	4.80702255
3	Congenital stationary night blindness (HP:0007642)	4.37965705
4	Absent septum pellucidum (HP:0001331)	4.13756448
5	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	4.08652557
6	Acute necrotizing encephalopathy (HP:0006965)	3.48107070
7	Abnormality of midbrain morphology (HP:0002418)	3.29006618
8	Molar tooth sign on MRI (HP:0002419)	3.29006618
9	Abnormality of the septum pellucidum (HP:0007375)	3.27762453
10	Mitochondrial inheritance (HP:0001427)	3.21910304
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20951023
12	Growth hormone deficiency (HP:0000824)	3.18478817
13	Retinal dysplasia (HP:0007973)	3.04638881
14	Hepatocellular necrosis (HP:0001404)	3.03710315
15	Type II lissencephaly (HP:0007260)	2.95773297
16	Acute encephalopathy (HP:0006846)	2.90824224
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.89301923
18	Agitation (HP:0000713)	2.89078099
19	Progressive macrocephaly (HP:0004481)	2.86934632
20	Nephronophthisis (HP:0000090)	2.86739162
21	Pendular nystagmus (HP:0012043)	2.84959714
22	Increased CSF lactate (HP:0002490)	2.83366254
23	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.83225170
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.75500055
25	Hepatic necrosis (HP:0002605)	2.73942483
26	True hermaphroditism (HP:0010459)	2.69717958
27	Pancreatic cysts (HP:0001737)	2.60229845
28	Polyphagia (HP:0002591)	2.52819065
29	Abnormality of the labia minora (HP:0012880)	2.51149428
30	Methylmalonic aciduria (HP:0012120)	2.44468817
31	Decreased central vision (HP:0007663)	2.44389619
32	Limb dystonia (HP:0002451)	2.42612937
33	Hypoplasia of the pons (HP:0012110)	2.40692172
34	Oligodactyly (hands) (HP:0001180)	2.40278138
35	Absent speech (HP:0001344)	2.40068238
36	Partial duplication of thumb phalanx (HP:0009944)	2.38661422
37	Stomach cancer (HP:0012126)	2.37879372
38	Pancreatic fibrosis (HP:0100732)	2.37748224
39	Hyperthyroidism (HP:0000836)	2.34521026
40	Enlarged penis (HP:0000040)	2.33574065
41	Colon cancer (HP:0003003)	2.32638533
42	Optic disc pallor (HP:0000543)	2.29805009
43	Abnormality of the renal medulla (HP:0100957)	2.26522424
44	Abnormality of B cell number (HP:0010975)	2.26401191
45	Lissencephaly (HP:0001339)	2.17943368
46	Progressive cerebellar ataxia (HP:0002073)	2.16588776
47	Abnormal ciliary motility (HP:0012262)	2.16477573
48	Cerebral hypomyelination (HP:0006808)	2.15003718
49	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.13374234
50	Absent/shortened dynein arms (HP:0200106)	2.13374234
51	Type I transferrin isoform profile (HP:0003642)	2.12436013
52	Humeroradial synostosis (HP:0003041)	2.11577319
53	Synostosis involving the elbow (HP:0003938)	2.11577319
54	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.08789173
55	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.08789173
56	Anencephaly (HP:0002323)	2.07947770
57	Broad-based gait (HP:0002136)	2.06910561
58	Renal Fanconi syndrome (HP:0001994)	1.98966321
59	Cerebral edema (HP:0002181)	1.98903897
60	Rectal fistula (HP:0100590)	1.98662633
61	Rectovaginal fistula (HP:0000143)	1.98662633
62	Sclerocornea (HP:0000647)	1.97210048
63	Abnormality of the pons (HP:0007361)	1.97018125
64	Abolished electroretinogram (ERG) (HP:0000550)	1.97004074
65	Absent thumb (HP:0009777)	1.96155009
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95225403
67	Rib fusion (HP:0000902)	1.94648892
68	Chronic hepatic failure (HP:0100626)	1.93972931
69	Attenuation of retinal blood vessels (HP:0007843)	1.89797570
70	Ketosis (HP:0001946)	1.89555015
71	Reduced antithrombin III activity (HP:0001976)	1.86359343
72	Gaze-evoked nystagmus (HP:0000640)	1.85837415
73	Hyperglycinemia (HP:0002154)	1.84285691
74	Abnormality of cells of the erythroid lineage (HP:0012130)	1.83834244
75	Increased corneal curvature (HP:0100692)	1.83375504
76	Keratoconus (HP:0000563)	1.83375504
77	Partial duplication of the phalanx of hand (HP:0009999)	1.82647139
78	Restlessness (HP:0000711)	1.80614093
79	Lipid accumulation in hepatocytes (HP:0006561)	1.79380882
80	Severe visual impairment (HP:0001141)	1.78856118
81	Abnormal respiratory motile cilium physiology (HP:0012261)	1.78309814
82	Menstrual irregularities (HP:0000858)	1.78215120
83	Increased serum lactate (HP:0002151)	1.77898609
84	Cerebellar dysplasia (HP:0007033)	1.77870814
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77591347
86	Abnormal respiratory epithelium morphology (HP:0012253)	1.77591347
87	Poor suck (HP:0002033)	1.77094581
88	Focal seizures (HP:0007359)	1.75721057
89	Lactic acidosis (HP:0003128)	1.75150859
90	Abnormal eating behavior (HP:0100738)	1.73627614
91	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.72420501
92	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.72420501
93	Pachygyria (HP:0001302)	1.69604127
94	Bifid tongue (HP:0010297)	1.67310662
95	Increased hepatocellular lipid droplets (HP:0006565)	1.64303889
96	Hypoplastic pelvis (HP:0008839)	1.63773983
97	Hyperventilation (HP:0002883)	1.63517410
98	Postaxial foot polydactyly (HP:0001830)	1.62639983
99	Abnormal protein N-linked glycosylation (HP:0012347)	1.62059580
100	Abnormal glycosylation (HP:0012345)	1.62059580

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.28010954
2	PINK1	3.24852303
3	CASK	3.03416356
4	STK16	2.80925686
5	MAP2K7	2.77435625
6	WNK3	2.76935744
7	FRK	2.62410649
8	KDR	2.46709400
9	TESK2	2.44055382
10	BMPR1B	2.36689366
11	MAPK13	2.29437067
12	DYRK2	2.29370866
13	ZAK	2.09839956
14	WNK4	2.06392182
15	ADRBK2	2.01153082
16	CSNK1G2	1.98147830
17	CSNK1G3	1.85401101
18	CSNK1G1	1.77730084
19	NTRK2	1.74428857
20	PNCK	1.72960967
21	TNIK	1.72128121
22	CSNK1A1L	1.70638802
23	MAPK15	1.61540893
24	ERBB3	1.50569344
25	NTRK3	1.48775488
26	GRK1	1.38278922
27	MAP3K4	1.34860496
28	STK39	1.34659566
29	EPHA4	1.33138857
30	CAMKK2	1.31190133
31	MAP4K2	1.18847286
32	TAOK3	1.15721740
33	PDK2	1.14754036
34	MAP3K9	1.14491271
35	PKN1	1.12491122
36	PAK3	1.11910566
37	OXSR1	1.09636569
38	CLK1	1.04788535
39	TNK2	1.03077485
40	EPHB2	1.02592122
41	NUAK1	1.00936170
42	CDK8	0.96509777
43	PLK2	0.95360634
44	VRK2	0.92292150
45	VRK1	0.92054147
46	GRK7	0.88418230
47	PRKCE	0.88294253
48	STK38L	0.87176728
49	PHKG1	0.86988835
50	PHKG2	0.86988835
51	GRK5	0.86157483
52	PRKCG	0.85919908
53	RPS6KA5	0.79193561
54	MAP3K13	0.75426735
55	OBSCN	0.74464179
56	NME1	0.73754130
57	TRIM28	0.73519687
58	FGFR2	0.71395759
59	MAPKAPK5	0.67637215
60	LIMK1	0.66068203
61	KIT	0.65796065
62	INSRR	0.64978338
63	PLK4	0.63000877
64	BCR	0.60254297
65	BCKDK	0.60144722
66	MINK1	0.56059744
67	ARAF	0.55886538
68	ADRBK1	0.55128833
69	PRKCI	0.53893403
70	EIF2AK3	0.51233181
71	GRK6	0.50478066
72	TGFBR1	0.49544901
73	CAMK2A	0.48173205
74	CSNK1D	0.47622497
75	CAMKK1	0.47508071
76	TXK	0.46197564
77	CAMK1	0.46136245
78	AURKA	0.45620949
79	PRKACA	0.44197114
80	CAMK2B	0.44003273
81	SGK494	0.43521299
82	SGK223	0.43521299
83	CDK14	0.43500983
84	PRKCQ	0.43080701
85	ACVR1B	0.39814066
86	CDK5	0.36735591
87	CSNK1A1	0.36007362
88	TAF1	0.35544265
89	TIE1	0.33821972
90	PRKCA	0.32392578
91	SYK	0.31674708
92	TESK1	0.30988426
93	IRAK4	0.30793677
94	PLK1	0.29578235
95	AKT3	0.29193489
96	PAK1	0.28402421
97	MUSK	0.27409683
98	STK38	0.26997475
99	ROCK1	0.26888421
100	MAP4K1	0.26864498

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.11867661
2	Parkinsons disease_Homo sapiens_hsa05012	3.66614927
3	Proteasome_Homo sapiens_hsa03050	3.12492921
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.00265031
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.88112475
6	Alzheimers disease_Homo sapiens_hsa05010	2.71995540
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.61395000
8	Nicotine addiction_Homo sapiens_hsa05033	2.55626188
9	Huntingtons disease_Homo sapiens_hsa05016	2.50085609
10	Protein export_Homo sapiens_hsa03060	2.41137321
11	Cardiac muscle contraction_Homo sapiens_hsa04260	2.24625704
12	Ribosome_Homo sapiens_hsa03010	2.23385545
13	Butanoate metabolism_Homo sapiens_hsa00650	2.02854153
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.01546361
15	Phototransduction_Homo sapiens_hsa04744	2.01197483
16	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.99604670
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.81436199
18	Basal transcription factors_Homo sapiens_hsa03022	1.76874252
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70257409
20	RNA polymerase_Homo sapiens_hsa03020	1.63151434
21	Propanoate metabolism_Homo sapiens_hsa00640	1.52845410
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.52805276
23	Homologous recombination_Homo sapiens_hsa03440	1.39136630
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.33247848
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24928420
26	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.20906658
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.20500780
28	Morphine addiction_Homo sapiens_hsa05032	1.14731089
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.13241784
30	Circadian entrainment_Homo sapiens_hsa04713	1.10194946
31	Olfactory transduction_Homo sapiens_hsa04740	1.09251891
32	Primary immunodeficiency_Homo sapiens_hsa05340	1.07684785
33	Caffeine metabolism_Homo sapiens_hsa00232	1.07520300
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.06325225
35	Glutamatergic synapse_Homo sapiens_hsa04724	1.05319841
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02292279
37	GABAergic synapse_Homo sapiens_hsa04727	1.02025901
38	Asthma_Homo sapiens_hsa05310	0.99580054
39	Taste transduction_Homo sapiens_hsa04742	0.99190918
40	Amphetamine addiction_Homo sapiens_hsa05031	0.97275252
41	Peroxisome_Homo sapiens_hsa04146	0.93071149
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.92244571
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.90646414
44	Dopaminergic synapse_Homo sapiens_hsa04728	0.87067643
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.86299771
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85373788
47	Cocaine addiction_Homo sapiens_hsa05030	0.84909459
48	Insulin secretion_Homo sapiens_hsa04911	0.83599035
49	Type I diabetes mellitus_Homo sapiens_hsa04940	0.82830120
50	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77666549
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77028894
52	Regulation of autophagy_Homo sapiens_hsa04140	0.75253661
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72906377
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70064528
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69887539
56	RNA degradation_Homo sapiens_hsa03018	0.69406804
57	Salivary secretion_Homo sapiens_hsa04970	0.69253606
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68727725
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.66262799
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.65491020
61	Fatty acid degradation_Homo sapiens_hsa00071	0.65010830
62	Linoleic acid metabolism_Homo sapiens_hsa00591	0.61071373
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.60617840
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.60525565
65	Allograft rejection_Homo sapiens_hsa05330	0.60496223
66	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.58744900
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58473766
68	Retinol metabolism_Homo sapiens_hsa00830	0.57831444
69	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.57514740
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.57381318
71	Axon guidance_Homo sapiens_hsa04360	0.56738295
72	Metabolic pathways_Homo sapiens_hsa01100	0.54273318
73	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53056488
74	Antigen processing and presentation_Homo sapiens_hsa04612	0.52357953
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51764660
76	Renin secretion_Homo sapiens_hsa04924	0.50794780
77	Serotonergic synapse_Homo sapiens_hsa04726	0.50578992
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.48070382
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.47824276
80	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.47234128
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46890943
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.45627085
83	cAMP signaling pathway_Homo sapiens_hsa04024	0.42124387
84	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41252858
85	Gastric acid secretion_Homo sapiens_hsa04971	0.40176096
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39497888
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.39200227
88	Alcoholism_Homo sapiens_hsa05034	0.38158634
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37271593
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36508487
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.33950083
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.33253648
93	RNA transport_Homo sapiens_hsa03013	0.32754498
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32651769
95	Rheumatoid arthritis_Homo sapiens_hsa05323	0.32368802
96	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31337175
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.30460880
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.29729854
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.28555285
100	Purine metabolism_Homo sapiens_hsa00230	0.28381279

EEF1DP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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