ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	7.27456771
2	cell wall macromolecule metabolic process (GO:0044036)	5.99475524
3	presynaptic membrane organization (GO:0097090)	5.80178525
4	presynaptic membrane assembly (GO:0097105)	5.11379602
5	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.97014210
6	axonal fasciculation (GO:0007413)	4.93306233
7	short-term memory (GO:0007614)	4.83862146
8	gamma-aminobutyric acid transport (GO:0015812)	4.60867680
9	regulation of cilium movement (GO:0003352)	4.47879083
10	neuron recognition (GO:0008038)	4.26353573
11	cerebral cortex radially oriented cell migration (GO:0021799)	4.24692898
12	glutamate receptor signaling pathway (GO:0007215)	4.23697789
13	postsynaptic membrane organization (GO:0001941)	4.22554040
14	fibroblast migration (GO:0010761)	4.14797325
15	pyrimidine nucleobase catabolic process (GO:0006208)	3.97516333
16	synaptic transmission, glutamatergic (GO:0035249)	3.91621688
17	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.86333593
18	neuron cell-cell adhesion (GO:0007158)	3.79815407
19	behavioral response to nicotine (GO:0035095)	3.70787829
20	vocalization behavior (GO:0071625)	3.67578605
21	neuronal action potential propagation (GO:0019227)	3.66520563
22	retinal rod cell development (GO:0046548)	3.65738899
23	myelin assembly (GO:0032288)	3.65550616
24	regulation of dendritic spine morphogenesis (GO:0061001)	3.63396251
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.57223978
26	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.56592263
27	neuromuscular synaptic transmission (GO:0007274)	3.49945602
28	nonmotile primary cilium assembly (GO:0035058)	3.44161879
29	phasic smooth muscle contraction (GO:0014821)	3.43341862
30	protein polyglutamylation (GO:0018095)	3.40647295
31	righting reflex (GO:0060013)	3.36559295
32	positive regulation of dendrite morphogenesis (GO:0050775)	3.35334913
33	negative regulation of systemic arterial blood pressure (GO:0003085)	3.30903729
34	protein localization to cilium (GO:0061512)	3.29793531
35	cyclic nucleotide catabolic process (GO:0009214)	3.28970221
36	glycosphingolipid biosynthetic process (GO:0006688)	3.27859179
37	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.27656908
38	nucleobase catabolic process (GO:0046113)	3.27156191
39	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.18371497
40	negative regulation of dendrite development (GO:2000171)	3.18303834
41	negative regulation of mast cell activation (GO:0033004)	3.17597077
42	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.16988369
43	synaptic vesicle endocytosis (GO:0048488)	3.16461650
44	cAMP catabolic process (GO:0006198)	3.11781099
45	protein-cofactor linkage (GO:0018065)	3.11221465
46	protein K11-linked deubiquitination (GO:0035871)	3.10291386
47	microtubule anchoring (GO:0034453)	3.09689035
48	dendrite morphogenesis (GO:0048813)	3.08214700
49	negative regulation of appetite (GO:0032099)	3.08016361
50	negative regulation of response to food (GO:0032096)	3.08016361
51	auditory receptor cell stereocilium organization (GO:0060088)	3.04774563
52	brain morphogenesis (GO:0048854)	3.04084243
53	neuron-neuron synaptic transmission (GO:0007270)	3.04011532
54	intraciliary transport (GO:0042073)	3.02644362
55	inner ear receptor stereocilium organization (GO:0060122)	3.00694936
56	resolution of meiotic recombination intermediates (GO:0000712)	2.99394843
57	regulation of dendritic spine development (GO:0060998)	2.99386410
58	C4-dicarboxylate transport (GO:0015740)	2.98835708
59	central nervous system projection neuron axonogenesis (GO:0021952)	2.96645130
60	regulation of MHC class II biosynthetic process (GO:0045346)	2.95073663
61	regulation of microtubule-based movement (GO:0060632)	2.92386943
62	transmission of nerve impulse (GO:0019226)	2.91705667
63	cellular response to leptin stimulus (GO:0044320)	2.91045806
64	positive regulation of meiosis (GO:0045836)	2.88842320
65	startle response (GO:0001964)	2.85519892
66	neurotransmitter-gated ion channel clustering (GO:0072578)	2.78667955
67	monoubiquitinated protein deubiquitination (GO:0035520)	2.78620832
68	reflex (GO:0060004)	2.77890775
69	peristalsis (GO:0030432)	2.77831651
70	metallo-sulfur cluster assembly (GO:0031163)	2.75240583
71	iron-sulfur cluster assembly (GO:0016226)	2.75240583
72	DNA double-strand break processing (GO:0000729)	2.74788063
73	synapse assembly (GO:0007416)	2.74683760
74	regulation of neuron projection regeneration (GO:0070570)	2.74317742
75	regulation of axon regeneration (GO:0048679)	2.74317742
76	positive regulation of dendritic spine development (GO:0060999)	2.73306652
77	photoreceptor cell maintenance (GO:0045494)	2.72343276
78	cell migration in hindbrain (GO:0021535)	2.71557422
79	positive regulation of meiotic cell cycle (GO:0051446)	2.70755126
80	axoneme assembly (GO:0035082)	2.70676776
81	regulation of penile erection (GO:0060405)	2.70482907
82	positive regulation of synapse assembly (GO:0051965)	2.69655608
83	positive regulation of amino acid transport (GO:0051957)	2.69156498
84	regulation of mitotic spindle checkpoint (GO:1903504)	2.66565329
85	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.66565329
86	regulation of action potential (GO:0098900)	2.65554808
87	regulation of dendrite morphogenesis (GO:0048814)	2.63912165
88	negative regulation of adenylate cyclase activity (GO:0007194)	2.60960406
89	serotonin metabolic process (GO:0042428)	2.60324755
90	positive regulation of membrane potential (GO:0045838)	2.58981013
91	regulation of timing of cell differentiation (GO:0048505)	2.58965280
92	negative regulation of telomere maintenance (GO:0032205)	2.58736956
93	hippocampus development (GO:0021766)	2.58209200
94	neurotransmitter catabolic process (GO:0042135)	2.57428823
95	response to leptin (GO:0044321)	2.57298686
96	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.56263092
97	positive regulation of dendrite development (GO:1900006)	2.55909974
98	retinal cone cell development (GO:0046549)	2.55572555
99	synaptic vesicle exocytosis (GO:0016079)	2.55495535
100	photoreceptor cell development (GO:0042461)	2.54538435

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.64115167
2	RBPJ_22232070_ChIP-Seq_NCS_Mouse	4.21572954
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.46662248
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.94152593
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.91200783
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65358475
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.48060769
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.46780425
9	VDR_22108803_ChIP-Seq_LS180_Human	2.45721761
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.40932214
11	REST_21632747_ChIP-Seq_MESCs_Mouse	2.40614631
12	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.22647104
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.21007465
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.17984259
15	AR_21572438_ChIP-Seq_LNCaP_Human	2.15047363
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08946764
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07341346
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.03681083
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00786165
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.86990477
21	P300_19829295_ChIP-Seq_ESCs_Human	1.83953021
22	FUS_26573619_Chip-Seq_HEK293_Human	1.83523601
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.76296369
24	DROSHA_22980978_ChIP-Seq_HELA_Human	1.75167282
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.74504682
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72147158
27	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.68540892
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63889699
29	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.63094869
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.56031202
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56031202
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53922720
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52582654
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.51750891
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49879961
36	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.49391199
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.48567422
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46705912
39	TCF4_23295773_ChIP-Seq_U87_Human	1.45133325
40	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44827835
41	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.43325627
42	EWS_26573619_Chip-Seq_HEK293_Human	1.42493009
43	AR_25329375_ChIP-Seq_VCAP_Human	1.41178641
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40035934
45	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38433079
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.37878769
47	STAT3_23295773_ChIP-Seq_U87_Human	1.34975079
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33997101
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33688623
50	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33590405
51	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.32621699
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32617659
53	TAF15_26573619_Chip-Seq_HEK293_Human	1.32452934
54	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31228168
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31228168
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26111092
57	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.25626209
58	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.24780604
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23531206
60	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23298439
61	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22782675
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21264462
63	BCAT_22108803_ChIP-Seq_LS180_Human	1.21214009
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.21129050
65	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.20531298
66	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19080634
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18474671
68	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18399705
69	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16517032
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15953245
71	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.15591190
72	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14926227
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14541771
74	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14541771
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14386106
76	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13109522
77	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12408222
78	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.11931471
79	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.11692719
80	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11673718
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11348256
82	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.10803769
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09559899
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05969733
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05392071
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.05371007
87	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.03175157
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02852886
89	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.02470413
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02143648
91	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00561590
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99563540
93	RARB_27405468_Chip-Seq_BRAIN_Mouse	0.98833524
94	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.98806754
95	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.97942198
96	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.97012556
97	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96132161
98	P300_18555785_Chip-Seq_ESCs_Mouse	0.96019860
99	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95507100
100	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.95421051

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	5.47386207
2	MP0002822_catalepsy	4.59368136
3	MP0005423_abnormal_somatic_nervous	3.45837826
4	MP0002735_abnormal_chemical_nociception	3.21749537
5	MP0002736_abnormal_nociception_after	3.21727695
6	MP0001968_abnormal_touch/_nociception	3.18179094
7	MP0001984_abnormal_olfaction	2.95497895
8	MP0004147_increased_porphyrin_level	2.65791865
9	MP0004859_abnormal_synaptic_plasticity	2.47000774
10	MP0003635_abnormal_synaptic_transmissio	2.43614136
11	MP0008789_abnormal_olfactory_epithelium	2.36918746
12	MP0009745_abnormal_behavioral_response	2.24118538
13	MP0002734_abnormal_mechanical_nocicepti	2.13582507
14	MP0002272_abnormal_nervous_system	2.12872326
15	MP0004742_abnormal_vestibular_system	2.11582706
16	MP0000566_synostosis	2.11317434
17	MP0001970_abnormal_pain_threshold	2.07197559
18	MP0005394_taste/olfaction_phenotype	2.06623345
19	MP0005499_abnormal_olfactory_system	2.06623345
20	MP0005645_abnormal_hypothalamus_physiol	2.02337960
21	MP0004270_analgesia	2.02210511
22	MP0002064_seizures	2.01479001
23	MP0000778_abnormal_nervous_system	1.97255593
24	MP0001529_abnormal_vocalization	1.96390545
25	MP0004924_abnormal_behavior	1.94381120
26	MP0005386_behavior/neurological_phenoty	1.94381120
27	MP0002063_abnormal_learning/memory/cond	1.91557726
28	MP0009046_muscle_twitch	1.90784492
29	MP0004885_abnormal_endolymph	1.84915829
30	MP0005551_abnormal_eye_electrophysiolog	1.81061379
31	MP0008877_abnormal_DNA_methylation	1.79038264
32	MP0001986_abnormal_taste_sensitivity	1.78210007
33	MP0003787_abnormal_imprinting	1.77081422
34	MP0002572_abnormal_emotion/affect_behav	1.74674122
35	MP0001486_abnormal_startle_reflex	1.74608721
36	MP0002733_abnormal_thermal_nociception	1.67821591
37	MP0002557_abnormal_social/conspecific_i	1.54218852
38	MP0001188_hyperpigmentation	1.53614606
39	MP0010030_abnormal_orbit_morphology	1.50637149
40	MP0001502_abnormal_circadian_rhythm	1.49277779
41	MP0003718_maternal_effect	1.47137241
42	MP0002102_abnormal_ear_morphology	1.45239782
43	MP0002067_abnormal_sensory_capabilities	1.40977384
44	MP0002882_abnormal_neuron_morphology	1.27578964
45	MP0006292_abnormal_olfactory_placode	1.23633907
46	MP0000955_abnormal_spinal_cord	1.22828647
47	MP0002638_abnormal_pupillary_reflex	1.22027766
48	MP0000631_abnormal_neuroendocrine_gland	1.19061155
49	MP0003567_abnormal_fetal_cardiomyocyte	1.19005550
50	MP0008995_early_reproductive_senescence	1.17761779
51	MP0008569_lethality_at_weaning	1.15803400
52	MP0001440_abnormal_grooming_behavior	1.14917338
53	MP0000026_abnormal_inner_ear	1.13065878
54	MP0002837_dystrophic_cardiac_calcinosis	1.12355628
55	MP0002751_abnormal_autonomic_nervous	1.06176832
56	MP0002938_white_spotting	1.05519663
57	MP0002066_abnormal_motor_capabilities/c	1.05182019
58	MP0002752_abnormal_somatic_nervous	1.04537769
59	MP0004811_abnormal_neuron_physiology	1.03521798
60	MP0003121_genomic_imprinting	1.02843903
61	MP0002069_abnormal_eating/drinking_beha	1.00971063
62	MP0002249_abnormal_larynx_morphology	1.00733243
63	MP0001963_abnormal_hearing_physiology	1.00613457
64	MP0004142_abnormal_muscle_tone	0.98826868
65	MP0000613_abnormal_salivary_gland	0.98337273
66	MP0000049_abnormal_middle_ear	0.90915950
67	MP0002152_abnormal_brain_morphology	0.90816760
68	MP0008058_abnormal_DNA_repair	0.89018016
69	MP0006276_abnormal_autonomic_nervous	0.88614031
70	MP0003136_yellow_coat_color	0.87604233
71	MP0002184_abnormal_innervation	0.86700665
72	MP0001485_abnormal_pinna_reflex	0.84906818
73	MP0008872_abnormal_physiological_respon	0.82361195
74	MP0003122_maternal_imprinting	0.82044754
75	MP0002229_neurodegeneration	0.80410662
76	MP0003011_delayed_dark_adaptation	0.78177240
77	MP0005187_abnormal_penis_morphology	0.76662915
78	MP0008875_abnormal_xenobiotic_pharmacok	0.76415309
79	MP0003861_abnormal_nervous_system	0.75014573
80	MP0002876_abnormal_thyroid_physiology	0.73663677
81	MP0005646_abnormal_pituitary_gland	0.73501838
82	MP0005195_abnormal_posterior_eye	0.72391237
83	MP0002233_abnormal_nose_morphology	0.72154990
84	MP0000516_abnormal_urinary_system	0.70025653
85	MP0005367_renal/urinary_system_phenotyp	0.70025653
86	MP0000639_abnormal_adrenal_gland	0.68893181
87	MP0003938_abnormal_ear_development	0.66670318
88	MP0003755_abnormal_palate_morphology	0.66451764
89	MP0000920_abnormal_myelination	0.64801082
90	MP0005395_other_phenotype	0.62593450
91	MP0001929_abnormal_gametogenesis	0.61251848
92	MP0003698_abnormal_male_reproductive	0.61238565
93	MP0001501_abnormal_sleep_pattern	0.60722679
94	MP0005253_abnormal_eye_physiology	0.60648657
95	MP0000013_abnormal_adipose_tissue	0.59887261
96	MP0005084_abnormal_gallbladder_morpholo	0.57737674
97	MP0003935_abnormal_craniofacial_develop	0.57664422
98	MP0001764_abnormal_homeostasis	0.57305637
99	MP0001324_abnormal_eye_pigmentation	0.56072494
100	MP0010770_preweaning_lethality	0.55640648

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Broad-based gait (HP:0002136)	4.76747613
2	Hyperventilation (HP:0002883)	4.32668445
3	Septo-optic dysplasia (HP:0100842)	3.97183803
4	Type II lissencephaly (HP:0007260)	3.96499892
5	Absent speech (HP:0001344)	3.86445508
6	Retinal dysplasia (HP:0007973)	3.67930211
7	Pancreatic cysts (HP:0001737)	3.61713505
8	Focal motor seizures (HP:0011153)	3.50879360
9	Gait imbalance (HP:0002141)	3.45483594
10	Pendular nystagmus (HP:0012043)	3.23776411
11	Congenital primary aphakia (HP:0007707)	3.22867092
12	Medial flaring of the eyebrow (HP:0010747)	3.18963177
13	Conical tooth (HP:0000698)	3.18852069
14	Optic nerve hypoplasia (HP:0000609)	3.15382935
15	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.94289759
16	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.94289759
17	Cerebellar dysplasia (HP:0007033)	2.93738791
18	Pancreatic fibrosis (HP:0100732)	2.93701989
19	Nephrogenic diabetes insipidus (HP:0009806)	2.93613800
20	Focal seizures (HP:0007359)	2.89409837
21	Abnormality of the musculature of the pelvis (HP:0001469)	2.84130572
22	Abnormality of the hip-girdle musculature (HP:0001445)	2.84130572
23	Congenital stationary night blindness (HP:0007642)	2.82701736
24	Hepatocellular necrosis (HP:0001404)	2.74897640
25	Humeroradial synostosis (HP:0003041)	2.72254845
26	Synostosis involving the elbow (HP:0003938)	2.72254845
27	Acute necrotizing encephalopathy (HP:0006965)	2.65880609
28	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.64518298
29	True hermaphroditism (HP:0010459)	2.64038084
30	Shoulder girdle muscle weakness (HP:0003547)	2.63683859
31	Abnormality of midbrain morphology (HP:0002418)	2.60329452
32	Molar tooth sign on MRI (HP:0002419)	2.60329452
33	Poor coordination (HP:0002370)	2.53804723
34	Anosmia (HP:0000458)	2.52862323
35	Myokymia (HP:0002411)	2.44979915
36	Cystic liver disease (HP:0006706)	2.40069524
37	Progressive macrocephaly (HP:0004481)	2.39105972
38	Thickened helices (HP:0000391)	2.37739301
39	Acute encephalopathy (HP:0006846)	2.37595165
40	Mitochondrial inheritance (HP:0001427)	2.36652108
41	Exercise-induced muscle cramps (HP:0003710)	2.36136657
42	Genital tract atresia (HP:0001827)	2.34054771
43	Abnormality of the corticospinal tract (HP:0002492)	2.31241454
44	Nephronophthisis (HP:0000090)	2.29638790
45	Specific learning disability (HP:0001328)	2.29614575
46	Vaginal atresia (HP:0000148)	2.29328543
47	Preaxial foot polydactyly (HP:0001841)	2.29104486
48	Amblyopia (HP:0000646)	2.25237620
49	Cupped ear (HP:0000378)	2.23037469
50	Lissencephaly (HP:0001339)	2.23033292
51	Intestinal atresia (HP:0011100)	2.19876375
52	Increased corneal curvature (HP:0100692)	2.19101227
53	Keratoconus (HP:0000563)	2.19101227
54	Gaze-evoked nystagmus (HP:0000640)	2.14334432
55	Esotropia (HP:0000565)	2.14043045
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.12720750
57	Absent septum pellucidum (HP:0001331)	2.12513659
58	Pelvic girdle muscle weakness (HP:0003749)	2.11274518
59	Abnormal mitochondria in muscle tissue (HP:0008316)	2.09083698
60	Febrile seizures (HP:0002373)	2.08869157
61	Hepatic necrosis (HP:0002605)	2.08619544
62	Occipital encephalocele (HP:0002085)	2.07195399
63	Long nose (HP:0003189)	2.07153650
64	Stenosis of the external auditory canal (HP:0000402)	2.07111037
65	Maternal diabetes (HP:0009800)	2.06869706
66	Thyroid-stimulating hormone excess (HP:0002925)	2.05824216
67	Limb-girdle muscle atrophy (HP:0003797)	2.04103792
68	Short tibia (HP:0005736)	2.03863868
69	Hemiparesis (HP:0001269)	2.03537933
70	Abnormality of alanine metabolism (HP:0010916)	2.02161881
71	Hyperalaninemia (HP:0003348)	2.02161881
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02161881
73	Impaired vibration sensation in the lower limbs (HP:0002166)	2.01755292
74	Polyphagia (HP:0002591)	2.00468455
75	Gastrointestinal atresia (HP:0002589)	1.99237284
76	Abnormality of the labia minora (HP:0012880)	1.98895398
77	Narrow forehead (HP:0000341)	1.98770835
78	Unilateral renal agenesis (HP:0000122)	1.97601465
79	Progressive cerebellar ataxia (HP:0002073)	1.97283636
80	Widely spaced teeth (HP:0000687)	1.95205670
81	Postaxial hand polydactyly (HP:0001162)	1.95162267
82	Optic disc pallor (HP:0000543)	1.94360991
83	Megalencephaly (HP:0001355)	1.92265858
84	Renal cortical cysts (HP:0000803)	1.90600675
85	Abnormality of the renal cortex (HP:0011035)	1.90459008
86	Increased CSF lactate (HP:0002490)	1.88201860
87	Spastic gait (HP:0002064)	1.87365115
88	Stomach cancer (HP:0012126)	1.86708288
89	Atonic seizures (HP:0010819)	1.85072283
90	Broad foot (HP:0001769)	1.80776215
91	Type 2 muscle fiber atrophy (HP:0003554)	1.80270021
92	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.79377882
93	Abnormality of the renal medulla (HP:0100957)	1.78086906
94	Epileptic encephalopathy (HP:0200134)	1.77945825
95	Hypothermia (HP:0002045)	1.76395901
96	Epileptiform EEG discharges (HP:0011182)	1.75017179
97	Abnormal rod and cone electroretinograms (HP:0008323)	1.72996115
98	Hypogonadotrophic hypogonadism (HP:0000044)	1.72278551
99	Central scotoma (HP:0000603)	1.69498464
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68771902

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	6.59928822
2	EPHA4	4.78518956
3	MARK1	3.31728683
4	SIK2	3.04321933
5	CDK19	2.83819812
6	MAP3K4	2.40113439
7	MAP2K7	2.33033538
8	TIE1	2.12271498
9	WNK3	2.10149784
10	TRIM28	2.09001829
11	MAPK13	2.07236378
12	ARAF	1.95446708
13	MUSK	1.64226157
14	TNIK	1.58510619
15	MAP3K9	1.53292998
16	ADRBK2	1.46372612
17	MAP3K13	1.40005098
18	BCKDK	1.33672549
19	NTRK2	1.31992626
20	GRK1	1.28155950
21	DYRK2	1.24274297
22	PRKCG	1.24260138
23	CAMK1D	1.24004985
24	MAP4K2	1.14823045
25	PAK3	1.14039177
26	MINK1	1.10496696
27	UHMK1	1.08432160
28	EIF2AK3	1.06344429
29	OXSR1	1.04493272
30	PRKCE	1.03884738
31	CAMKK2	1.03790411
32	PHKG1	1.02500021
33	PHKG2	1.02500021
34	NTRK3	1.01955218
35	LIMK1	1.01560683
36	BCR	1.00553069
37	CSNK1G3	0.99545964
38	PRKD3	0.99199585
39	BRD4	0.98283731
40	ERBB3	0.97134805
41	CSNK1G2	0.97002032
42	CDK5	0.96563675
43	GRK5	0.93965934
44	INSRR	0.93208716
45	DAPK2	0.92972877
46	KDR	0.91431492
47	EPHB2	0.91153933
48	CSNK1A1L	0.90626765
49	CSNK1G1	0.89013782
50	GRK7	0.85329363
51	ADRBK1	0.85316630
52	CAMKK1	0.84826451
53	PRKCZ	0.83420778
54	BRAF	0.83420534
55	PLK2	0.82227211
56	FRK	0.81760752
57	CAMK2G	0.74071099
58	PINK1	0.73965780
59	FGFR1	0.73785465
60	DYRK1A	0.73454411
61	CAMK2B	0.71604910
62	TSSK6	0.69735879
63	MATK	0.67118015
64	PLK4	0.66700478
65	CAMK1G	0.66351965
66	CSNK1A1	0.62557946
67	KSR1	0.62237842
68	TYRO3	0.61443828
69	ILK	0.57846760
70	CDK3	0.57209797
71	AKT3	0.56366414
72	MAP2K4	0.53863611
73	CAMK2A	0.51991344
74	DMPK	0.51019934
75	LMTK2	0.50648894
76	CDK11A	0.49416838
77	ROCK1	0.49025906
78	PAK6	0.48360520
79	CDK18	0.45866433
80	PRKG1	0.45052905
81	PRKACA	0.44728637
82	PRKAA1	0.43598120
83	CDK15	0.43594960
84	NUAK1	0.43419087
85	CDK14	0.43072415
86	PRKCQ	0.43040568
87	FGR	0.42218332
88	CSNK1D	0.41837725
89	SGK1	0.41062616
90	BMPR1B	0.39896933
91	EPHA3	0.38775828
92	PASK	0.37749621
93	CAMK1	0.37643809
94	DAPK3	0.37284193
95	CAMK2D	0.37081520
96	SGK494	0.36772831
97	SGK223	0.36772831
98	PRKCA	0.35514628
99	PKN1	0.33760673
100	TESK1	0.32222536

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.95747474
2	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.66871762
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.46555886
4	Glutamatergic synapse_Homo sapiens_hsa04724	2.44444380
5	Phototransduction_Homo sapiens_hsa04744	2.44187700
6	Basal transcription factors_Homo sapiens_hsa03022	2.36759925
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.35851849
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.34312516
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31527230
10	Butanoate metabolism_Homo sapiens_hsa00650	2.28170748
11	Taste transduction_Homo sapiens_hsa04742	2.09050104
12	Circadian entrainment_Homo sapiens_hsa04713	2.03629957
13	Morphine addiction_Homo sapiens_hsa05032	2.02367086
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.91152926
15	GABAergic synapse_Homo sapiens_hsa04727	1.90177074
16	Homologous recombination_Homo sapiens_hsa03440	1.81759488
17	Parkinsons disease_Homo sapiens_hsa05012	1.77364751
18	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.71873259
19	Cocaine addiction_Homo sapiens_hsa05030	1.71566205
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71345236
21	Long-term depression_Homo sapiens_hsa04730	1.69647407
22	Amphetamine addiction_Homo sapiens_hsa05031	1.69523688
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.60042678
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.57960356
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.54490324
26	Propanoate metabolism_Homo sapiens_hsa00640	1.46254839
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.42666518
28	Huntingtons disease_Homo sapiens_hsa05016	1.32480711
29	Protein export_Homo sapiens_hsa03060	1.24749007
30	Alzheimers disease_Homo sapiens_hsa05010	1.24381463
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.21528334
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.19963193
33	Insulin secretion_Homo sapiens_hsa04911	1.19062914
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15451214
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.11629007
36	Cholinergic synapse_Homo sapiens_hsa04725	1.11508088
37	Gastric acid secretion_Homo sapiens_hsa04971	1.06860899
38	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.06729229
39	RNA degradation_Homo sapiens_hsa03018	1.03118507
40	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.02965138
41	Calcium signaling pathway_Homo sapiens_hsa04020	1.00060347
42	Serotonergic synapse_Homo sapiens_hsa04726	0.98534616
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.98306502
44	Olfactory transduction_Homo sapiens_hsa04740	0.98233498
45	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.95041085
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94711366
47	mRNA surveillance pathway_Homo sapiens_hsa03015	0.93879260
48	Sulfur metabolism_Homo sapiens_hsa00920	0.92750764
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.92320218
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.92046964
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91302080
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89036120
53	Base excision repair_Homo sapiens_hsa03410	0.87995422
54	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.86707944
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.82205310
56	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.82083001
57	Regulation of autophagy_Homo sapiens_hsa04140	0.80053371
58	Salivary secretion_Homo sapiens_hsa04970	0.79027254
59	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.78731819
60	Long-term potentiation_Homo sapiens_hsa04720	0.76107808
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.75992270
62	Axon guidance_Homo sapiens_hsa04360	0.74592808
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.72658623
64	Purine metabolism_Homo sapiens_hsa00230	0.72198209
65	Linoleic acid metabolism_Homo sapiens_hsa00591	0.70505168
66	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.70276535
67	Circadian rhythm_Homo sapiens_hsa04710	0.70100477
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.69843267
69	Renin secretion_Homo sapiens_hsa04924	0.69534229
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.68969734
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68061029
72	Caffeine metabolism_Homo sapiens_hsa00232	0.61843682
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60725842
74	Oocyte meiosis_Homo sapiens_hsa04114	0.59952883
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59360705
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59119019
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58974817
78	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58197607
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.57531628
80	Gap junction_Homo sapiens_hsa04540	0.57052207
81	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56637038
82	Melanogenesis_Homo sapiens_hsa04916	0.54808547
83	Retinol metabolism_Homo sapiens_hsa00830	0.53085516
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52731074
85	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51932962
86	Phagosome_Homo sapiens_hsa04145	0.51197116
87	Fanconi anemia pathway_Homo sapiens_hsa03460	0.50535256
88	Choline metabolism in cancer_Homo sapiens_hsa05231	0.50176981
89	Proteasome_Homo sapiens_hsa03050	0.48661366
90	RNA transport_Homo sapiens_hsa03013	0.48597742
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46680964
92	Sphingolipid metabolism_Homo sapiens_hsa00600	0.44217394
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.43846773
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42656006
95	Peroxisome_Homo sapiens_hsa04146	0.41461860
96	Tight junction_Homo sapiens_hsa04530	0.40358174
97	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.39436106
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.38329572
99	Metabolic pathways_Homo sapiens_hsa01100	0.37068169
100	Pancreatic secretion_Homo sapiens_hsa04972	0.36027952

EEF1DP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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