ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	potassium ion export (GO:0071435)	6.94859256
2	membrane repolarization during action potential (GO:0086011)	6.19122483
3	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	6.03229965
4	positive regulation of respiratory burst (GO:0060267)	4.72341211
5	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	4.49347764
6	positive regulation of chemokine biosynthetic process (GO:0045080)	4.11071792
7	negative regulation of growth of symbiont in host (GO:0044130)	4.00223032
8	negative regulation of growth of symbiont involved in interaction with host (GO:0044146)	4.00223032
9	modulation of growth of symbiont involved in interaction with host (GO:0044144)	4.00223032
10	regulation of growth of symbiont in host (GO:0044126)	4.00223032
11	membrane repolarization (GO:0086009)	3.99162842
12	phenylpropanoid metabolic process (GO:0009698)	3.97966027
13	mannosylation (GO:0097502)	3.85394077
14	respiratory chain complex IV assembly (GO:0008535)	3.84306880
15	cellular ketone body metabolic process (GO:0046950)	3.76284981
16	cardiovascular system development (GO:0072358)	3.64986949
17	positive regulation of potassium ion transmembrane transport (GO:1901381)	3.51273042
18	ribosomal small subunit assembly (GO:0000028)	3.32590157
19	kinetochore assembly (GO:0051382)	3.30111398
20	axoneme assembly (GO:0035082)	3.29988199
21	L-fucose catabolic process (GO:0042355)	3.28280007
22	fucose catabolic process (GO:0019317)	3.28280007
23	L-fucose metabolic process (GO:0042354)	3.28280007
24	ketone body metabolic process (GO:1902224)	3.28170573
25	positive regulation of steroid hormone secretion (GO:2000833)	3.26932184
26	regulation of chemokine biosynthetic process (GO:0045073)	3.25997556
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.25228479
28	negative regulation of B cell proliferation (GO:0030889)	3.25002564
29	behavioral response to nicotine (GO:0035095)	3.18789118
30	cytochrome complex assembly (GO:0017004)	3.14775954
31	GPI anchor biosynthetic process (GO:0006506)	3.12547606
32	regulation of membrane repolarization (GO:0060306)	3.11105463
33	preassembly of GPI anchor in ER membrane (GO:0016254)	3.10951186
34	auditory receptor cell stereocilium organization (GO:0060088)	3.07518359
35	regulation of action potential (GO:0098900)	3.06270445
36	regulation of mitotic spindle checkpoint (GO:1903504)	3.05171442
37	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.05171442
38	cellular response to exogenous dsRNA (GO:0071360)	3.02214150
39	positive regulation of toll-like receptor signaling pathway (GO:0034123)	3.00433273
40	endocrine hormone secretion (GO:0060986)	2.97380448
41	regulation of respiratory burst (GO:0060263)	2.97283653
42	GPI anchor metabolic process (GO:0006505)	2.96284452
43	estrogen biosynthetic process (GO:0006703)	2.94128961
44	photoreceptor cell development (GO:0042461)	2.94095893
45	negative regulation of cAMP-mediated signaling (GO:0043951)	2.91479424
46	cellular response to interferon-beta (GO:0035458)	2.89128939
47	pattern specification involved in kidney development (GO:0061004)	2.86031672
48	negative regulation of alpha-beta T cell activation (GO:0046636)	2.84802649
49	post-embryonic morphogenesis (GO:0009886)	2.84708938
50	flavonoid metabolic process (GO:0009812)	2.84405858
51	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.83668611
52	neuron fate determination (GO:0048664)	2.83189043
53	C-terminal protein lipidation (GO:0006501)	2.81412970
54	radial glial cell differentiation (GO:0060019)	2.79800328
55	acrosome assembly (GO:0001675)	2.76632872
56	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	2.76298327
57	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	2.76298327
58	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.76149576
59	regulation of alpha-beta T cell proliferation (GO:0046640)	2.75762412
60	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.74777847
61	nephron tubule morphogenesis (GO:0072078)	2.71911706
62	nephron epithelium morphogenesis (GO:0072088)	2.71911706
63	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.70720755
64	inositol phosphate dephosphorylation (GO:0046855)	2.70720755
65	hypothalamus development (GO:0021854)	2.70456783
66	translational termination (GO:0006415)	2.68270552
67	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68191773
68	regulation of heart rate by cardiac conduction (GO:0086091)	2.67362083
69	negative regulation of mast cell activation (GO:0033004)	2.66807871
70	base-excision repair, AP site formation (GO:0006285)	2.66725490
71	spermatid nucleus differentiation (GO:0007289)	2.66368851
72	regulation of glucokinase activity (GO:0033131)	2.64453987
73	regulation of hexokinase activity (GO:1903299)	2.64453987
74	GTP biosynthetic process (GO:0006183)	2.61614273
75	viral transcription (GO:0019083)	2.60722080
76	negative regulation of heart rate (GO:0010459)	2.60598257
77	disruption of cells of other organism (GO:0044364)	2.60562654
78	killing of cells of other organism (GO:0031640)	2.60562654
79	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	2.59653672
80	GDP-mannose metabolic process (GO:0019673)	2.59357555
81	antigen processing and presentation via MHC class Ib (GO:0002475)	2.59288451
82	kinetochore organization (GO:0051383)	2.58674125
83	regulation of isotype switching to IgG isotypes (GO:0048302)	2.56671197
84	regulation of vacuole organization (GO:0044088)	2.56259206
85	fatty acid transmembrane transport (GO:1902001)	2.54771603
86	eye photoreceptor cell development (GO:0042462)	2.54709798
87	protein-cofactor linkage (GO:0018065)	2.54148680
88	positive regulation of B cell differentiation (GO:0045579)	2.50296915
89	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.49533504
90	inositol phosphate catabolic process (GO:0071545)	2.49190618
91	retinal cone cell development (GO:0046549)	2.48743471
92	xenobiotic catabolic process (GO:0042178)	2.48671363
93	inner ear receptor stereocilium organization (GO:0060122)	2.47936630
94	regulation of autophagic vacuole assembly (GO:2000785)	2.47106526
95	rRNA modification (GO:0000154)	2.46819525
96	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	2.44254235
97	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	2.44254235
98	cAMP catabolic process (GO:0006198)	2.44074205
99	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.43040337
100	protein complex biogenesis (GO:0070271)	2.42184445

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IRF8_22096565_ChIP-ChIP_GC-B_Human	4.64939180
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.57676849
3	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	4.44141803
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.09397371
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.03689044
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.97038774
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.92885026
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.81141423
9	VDR_22108803_ChIP-Seq_LS180_Human	2.50658432
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.43980014
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.43075270
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.42813611
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.20075466
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.08388153
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04617599
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02043438
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.90178215
18	EWS_26573619_Chip-Seq_HEK293_Human	1.87498244
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.79955910
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79691047
21	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.79296986
22	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.77780815
23	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.77780815
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.72420381
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.68771840
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.61833058
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60493189
28	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.57901112
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.57088070
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.55742534
31	AR_20517297_ChIP-Seq_VCAP_Human	1.55344611
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.53579659
33	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52570543
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.50544081
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49783298
36	BCAT_22108803_ChIP-Seq_LS180_Human	1.48605158
37	P300_19829295_ChIP-Seq_ESCs_Human	1.41786319
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41129433
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.40548850
40	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40092147
41	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.38795440
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.31554027
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.30190171
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.29486353
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29248726
46	GATA3_26560356_Chip-Seq_TH2_Human	1.28931767
47	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.27849874
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.24423908
49	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.23121787
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.21968334
51	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21414917
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21163786
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.20406262
54	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19418379
55	FUS_26573619_Chip-Seq_HEK293_Human	1.19200936
56	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19071467
57	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16861926
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15382313
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13820939
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.13603443
61	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.11679104
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08633266
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08633266
64	TP53_16413492_ChIP-PET_HCT116_Human	1.05989900
65	TCF4_22108803_ChIP-Seq_LS180_Human	1.04909501
66	NCOR_22424771_ChIP-Seq_293T_Human	1.04288517
67	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04024540
68	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.02495703
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00117648
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98414686
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97469530
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96442055
73	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.93705449
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92412055
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.92117475
76	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91662562
77	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.91322644
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.91162499
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.89354855
80	ERG_20517297_ChIP-Seq_VCAP_Human	0.89243982
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.88263575
82	AHR_22903824_ChIP-Seq_MCF-7_Human	0.87999648
83	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.87916802
84	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.86901703
85	AR_25329375_ChIP-Seq_VCAP_Human	0.86318178
86	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85048185
87	P300_27268052_Chip-Seq_Bcells_Human	0.84894557
88	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.84809010
89	CBP_20019798_ChIP-Seq_JUKART_Human	0.84809010
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.84570132
91	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.84238084
92	SMAD4_21799915_ChIP-Seq_A2780_Human	0.82843410
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.82817713
94	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.82804609
95	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.82296958
96	RUNX2_22187159_ChIP-Seq_PCA_Human	0.82200711
97	P53_22387025_ChIP-Seq_ESCs_Mouse	0.81524145
98	CDX2_22108803_ChIP-Seq_LS180_Human	0.81324470
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.81156775
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.80696291

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	7.09462411
2	MP0003878_abnormal_ear_physiology	7.09462411
3	MP0005671_abnormal_response_to	3.72452095
4	MP0001485_abnormal_pinna_reflex	3.27092371
5	MP0006292_abnormal_olfactory_placode	2.90740725
6	MP0003011_delayed_dark_adaptation	2.51429516
7	MP0000569_abnormal_digit_pigmentation	2.48439296
8	MP0001835_abnormal_antigen_presentation	2.20547270
9	MP0001661_extended_life_span	2.17412108
10	MP0003724_increased_susceptibility_to	2.16082587
11	MP0001873_stomach_inflammation	1.94101429
12	MP0008877_abnormal_DNA_methylation	1.90501727
13	MP0003787_abnormal_imprinting	1.86478059
14	MP0002138_abnormal_hepatobiliary_system	1.81002615
15	MP0009046_muscle_twitch	1.65330442
16	MP0002928_abnormal_bile_duct	1.64470017
17	MP0001919_abnormal_reproductive_system	1.60479322
18	MP0005000_abnormal_immune_tolerance	1.55373825
19	MP0005551_abnormal_eye_electrophysiolog	1.55159064
20	MP0005084_abnormal_gallbladder_morpholo	1.54993216
21	MP0003646_muscle_fatigue	1.54258681
22	MP0005174_abnormal_tail_pigmentation	1.53845701
23	MP0002148_abnormal_hypersensitivity_rea	1.53767345
24	MP0006072_abnormal_retinal_apoptosis	1.52491625
25	MP0001663_abnormal_digestive_system	1.51683325
26	MP0002254_reproductive_system_inflammat	1.51451801
27	MP0001881_abnormal_mammary_gland	1.45106001
28	MP0001800_abnormal_humoral_immune	1.44630093
29	MP0006276_abnormal_autonomic_nervous	1.41878571
30	MP0005075_abnormal_melanosome_morpholog	1.37216578
31	MP0008004_abnormal_stomach_pH	1.36782924
32	MP0004147_increased_porphyrin_level	1.36464656
33	MP0009333_abnormal_splenocyte_physiolog	1.35941382
34	MP0001486_abnormal_startle_reflex	1.32510605
35	MP0008775_abnormal_heart_ventricle	1.30474493
36	MP0001765_abnormal_ion_homeostasis	1.27531354
37	MP0001501_abnormal_sleep_pattern	1.27121483
38	MP0004215_abnormal_myocardial_fiber	1.26890206
39	MP0001790_abnormal_immune_system	1.26362590
40	MP0005387_immune_system_phenotype	1.26362590
41	MP0002163_abnormal_gland_morphology	1.24650281
42	MP0003806_abnormal_nucleotide_metabolis	1.21559288
43	MP0002723_abnormal_immune_serum	1.16409677
44	MP0003252_abnormal_bile_duct	1.15889377
45	MP0005365_abnormal_bile_salt	1.13740638
46	MP0009379_abnormal_foot_pigmentation	1.13428994
47	MP0004885_abnormal_endolymph	1.13277526
48	MP0001905_abnormal_dopamine_level	1.12104068
49	MP0005645_abnormal_hypothalamus_physiol	1.11776148
50	MP0002272_abnormal_nervous_system	1.08884811
51	MP0005389_reproductive_system_phenotype	1.05936535
52	MP0009785_altered_susceptibility_to	1.04354916
53	MP0003136_yellow_coat_color	1.03189442
54	MP0004742_abnormal_vestibular_system	1.01707473
55	MP0003137_abnormal_impulse_conducting	0.98983557
56	MP0005379_endocrine/exocrine_gland_phen	0.98132663
57	MP0003880_abnormal_central_pattern	0.98099255
58	MP0002837_dystrophic_cardiac_calcinosis	0.97900150
59	MP0002452_abnormal_antigen_presenting	0.96849630
60	MP0001968_abnormal_touch/_nociception	0.96646066
61	MP0004142_abnormal_muscle_tone	0.96553897
62	MP0005381_digestive/alimentary_phenotyp	0.95226569
63	MP0005253_abnormal_eye_physiology	0.94252175
64	MP0009764_decreased_sensitivity_to	0.93540127
65	MP0002420_abnormal_adaptive_immunity	0.91666896
66	MP0000026_abnormal_inner_ear	0.90431846
67	MP0000631_abnormal_neuroendocrine_gland	0.88900631
68	MP0001819_abnormal_immune_cell	0.88864525
69	MP0000372_irregular_coat_pigmentation	0.88769222
70	MP0003195_calcinosis	0.86624275
71	MP0002277_abnormal_respiratory_mucosa	0.86337380
72	MP0002736_abnormal_nociception_after	0.86105796
73	MP0005085_abnormal_gallbladder_physiolo	0.84746375
74	MP0000685_abnormal_immune_system	0.84479761
75	MP0000230_abnormal_systemic_arterial	0.83960372
76	MP0001958_emphysema	0.83913309
77	MP0009780_abnormal_chondrocyte_physiolo	0.83576872
78	MP0008469_abnormal_protein_level	0.82893841
79	MP0008875_abnormal_xenobiotic_pharmacok	0.82282715
80	MP0001963_abnormal_hearing_physiology	0.81167848
81	MP0008872_abnormal_physiological_respon	0.80666955
82	MP0003186_abnormal_redox_activity	0.79516569
83	MP0002405_respiratory_system_inflammati	0.78003473
84	MP0005646_abnormal_pituitary_gland	0.77244090
85	MP0005636_abnormal_mineral_homeostasis	0.76783013
86	MP0002653_abnormal_ependyma_morphology	0.76355397
87	MP0002693_abnormal_pancreas_physiology	0.76232150
88	MP0005448_abnormal_energy_balance	0.74904778
89	MP0002229_neurodegeneration	0.74014695
90	MP0002160_abnormal_reproductive_system	0.73254561
91	MP0004145_abnormal_muscle_electrophysio	0.71012019
92	MP0002139_abnormal_hepatobiliary_system	0.69022128
93	MP0005319_abnormal_enzyme/_coenzyme	0.68575288
94	MP0002876_abnormal_thyroid_physiology	0.67476244
95	MP0004782_abnormal_surfactant_physiolog	0.66330609
96	MP0001756_abnormal_urination	0.65929574
97	MP0005220_abnormal_exocrine_pancreas	0.64939364
98	MP0004043_abnormal_pH_regulation	0.63031807
99	MP0005195_abnormal_posterior_eye	0.62735510
100	MP0008058_abnormal_DNA_repair	0.60303839

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Ventricular fibrillation (HP:0001663)	5.54296865
2	Chronic sinusitis (HP:0011109)	4.39285676
3	Prolonged QT interval (HP:0001657)	3.45598545
4	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.40080632
5	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.40080632
6	Abolished electroretinogram (ERG) (HP:0000550)	3.31338808
7	Congenital stationary night blindness (HP:0007642)	3.21266331
8	Neonatal respiratory distress (HP:0002643)	3.07330465
9	Abnormality of midbrain morphology (HP:0002418)	3.06355866
10	Molar tooth sign on MRI (HP:0002419)	3.06355866
11	Median cleft lip (HP:0000161)	2.93795125
12	Stomatitis (HP:0010280)	2.78292545
13	Opisthotonus (HP:0002179)	2.76897670
14	Hypomagnesemia (HP:0002917)	2.74204774
15	Type II lissencephaly (HP:0007260)	2.69546044
16	Intestinal atresia (HP:0011100)	2.67396428
17	Large for gestational age (HP:0001520)	2.65328988
18	Broad alveolar ridges (HP:0000187)	2.59902479
19	Syncope (HP:0001279)	2.59520054
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.57781338
21	Increased circulating renin level (HP:0000848)	2.51105937
22	Focal motor seizures (HP:0011153)	2.47252049
23	Volvulus (HP:0002580)	2.46406158
24	Increased corneal curvature (HP:0100692)	2.46284416
25	Keratoconus (HP:0000563)	2.46284416
26	Nephronophthisis (HP:0000090)	2.45605144
27	Chorioretinal atrophy (HP:0000533)	2.41022756
28	Abnormal glycosylation (HP:0012345)	2.38684266
29	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.38684266
30	Abnormal protein N-linked glycosylation (HP:0012347)	2.38684266
31	Abnormal protein glycosylation (HP:0012346)	2.38684266
32	Abnormality of the corticospinal tract (HP:0002492)	2.38106392
33	Abnormal ciliary motility (HP:0012262)	2.37573000
34	Progressive microcephaly (HP:0000253)	2.35760952
35	Congenital sensorineural hearing impairment (HP:0008527)	2.34927739
36	Reduced antithrombin III activity (HP:0001976)	2.34404490
37	Pancreatic fibrosis (HP:0100732)	2.33050775
38	Abnormal respiratory motile cilium morphology (HP:0005938)	2.32098031
39	Abnormal respiratory epithelium morphology (HP:0012253)	2.32098031
40	Visual hallucinations (HP:0002367)	2.30761468
41	Abnormality of magnesium homeostasis (HP:0004921)	2.30348667
42	Vacuolated lymphocytes (HP:0001922)	2.22616567
43	Severe muscular hypotonia (HP:0006829)	2.22493763
44	Clumsiness (HP:0002312)	2.20605163
45	IgG deficiency (HP:0004315)	2.20341933
46	Recurrent bronchitis (HP:0002837)	2.18730725
47	Abnormal EKG (HP:0003115)	2.18505175
48	Type 2 muscle fiber atrophy (HP:0003554)	2.18008150
49	Attenuation of retinal blood vessels (HP:0007843)	2.17791026
50	Nonprogressive disorder (HP:0003680)	2.17637342
51	Inability to walk (HP:0002540)	2.13269438
52	Abnormality of the renal medulla (HP:0100957)	2.12629822
53	Sensory axonal neuropathy (HP:0003390)	2.10495207
54	Acute necrotizing encephalopathy (HP:0006965)	2.09950756
55	Polydipsia (HP:0001959)	2.07989302
56	Abnormal drinking behavior (HP:0030082)	2.07989302
57	Fair hair (HP:0002286)	2.06105951
58	Acute encephalopathy (HP:0006846)	2.05401243
59	Type I transferrin isoform profile (HP:0003642)	2.04956563
60	Metabolic alkalosis (HP:0200114)	2.04472804
61	Mitochondrial inheritance (HP:0001427)	2.02301314
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00969907
63	Increased CSF lactate (HP:0002490)	1.99834531
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.99356144
65	Gastrointestinal atresia (HP:0002589)	1.96768289
66	Elevated erythrocyte sedimentation rate (HP:0003565)	1.94423092
67	Gastrointestinal infarctions (HP:0005244)	1.94005357
68	Hypokalemic alkalosis (HP:0001949)	1.92920461
69	Hepatic necrosis (HP:0002605)	1.92912646
70	True hermaphroditism (HP:0010459)	1.90961258
71	Abnormality of the diencephalon (HP:0010662)	1.90624905
72	Absent/shortened dynein arms (HP:0200106)	1.89938735
73	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.89938735
74	Hypoplasia of the fovea (HP:0007750)	1.89596153
75	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.89596153
76	Widely spaced teeth (HP:0000687)	1.89510525
77	Congenital hepatic fibrosis (HP:0002612)	1.88899077
78	Severe visual impairment (HP:0001141)	1.88680860
79	Polyuria (HP:0000103)	1.87882135
80	Muscle fiber atrophy (HP:0100295)	1.87801885
81	Asplenia (HP:0001746)	1.87527288
82	Generalized hypopigmentation of hair (HP:0011358)	1.86601926
83	Disproportionate short-trunk short stature (HP:0003521)	1.86442582
84	Flat occiput (HP:0005469)	1.85928776
85	Abnormality of the renal cortex (HP:0011035)	1.84517104
86	Hyperinsulinemic hypoglycemia (HP:0000825)	1.83697465
87	Decreased circulating renin level (HP:0003351)	1.82523081
88	Progressive neurologic deterioration (HP:0002344)	1.80142307
89	Abnormality of renin-angiotensin system (HP:0000847)	1.79934476
90	Abnormality of the vertebral endplates (HP:0005106)	1.79510326
91	Chronic hepatic failure (HP:0100626)	1.78967968
92	Alkalosis (HP:0001948)	1.78729437
93	Optic nerve hypoplasia (HP:0000609)	1.76918171
94	Albinism (HP:0001022)	1.76359071
95	Constricted visual fields (HP:0001133)	1.75957680
96	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74732773
97	Abnormal respiratory motile cilium physiology (HP:0012261)	1.74236859
98	Hypoproteinemia (HP:0003075)	1.74027968
99	Abnormality of B cell number (HP:0010975)	1.73950441
100	Pulmonary infiltrates (HP:0002113)	1.73518283

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	3.04994632
2	CAMK1D	3.02080044
3	BMPR1B	2.97049333
4	CDK19	2.85368554
5	FRK	2.83900708
6	GRK1	2.83016369
7	BMPR2	2.56204452
8	TXK	2.41888554
9	ADRBK2	2.38659047
10	TAOK1	2.36076986
11	TIE1	2.24227969
12	TRPM7	2.21741503
13	WNK4	2.18789641
14	MAP4K2	2.08470389
15	MAP3K3	2.00293737
16	CAMK1G	1.97355963
17	BCKDK	1.94751412
18	MAPK15	1.90457377
19	MAPKAPK3	1.86645203
20	TEC	1.82977416
21	ZAK	1.69850022
22	CAMKK2	1.62377000
23	BTK	1.56489779
24	MST4	1.52140826
25	SYK	1.47841218
26	PNCK	1.44614490
27	TAOK3	1.38429105
28	MAP2K6	1.30659706
29	MAPK13	1.10161596
30	MAP2K3	1.09245532
31	IRAK1	1.02466623
32	LRRK2	1.01891275
33	MAP3K12	1.01529959
34	PRKD3	1.01006610
35	TLK1	0.98376647
36	PASK	0.98117921
37	STK39	0.98016001
38	DYRK2	0.96519016
39	CDK3	0.94784850
40	ITK	0.94498391
41	TNK2	0.93570269
42	RPS6KA5	0.91104778
43	PRKD2	0.88444933
44	OXSR1	0.87008171
45	ADRBK1	0.86984772
46	ROCK1	0.82561782
47	CAMK1	0.81487503
48	IRAK2	0.80895481
49	PHKG2	0.79271174
50	PHKG1	0.79271174
51	WNK1	0.76307424
52	IKBKB	0.74776717
53	MAP4K1	0.73842400
54	RPS6KA4	0.73280089
55	LIMK1	0.72332840
56	WEE1	0.71471876
57	KIT	0.70299730
58	ERBB3	0.70022974
59	LYN	0.68837844
60	INSRR	0.68123177
61	PIK3CA	0.66964737
62	PRKCQ	0.66681272
63	MAP2K2	0.65740639
64	JAK3	0.65369271
65	NLK	0.64859085
66	CAMKK1	0.63188119
67	RIPK4	0.62725805
68	CSF1R	0.62578594
69	CCNB1	0.59919811
70	NME1	0.59370711
71	HCK	0.58172820
72	GRK6	0.57899034
73	WNK3	0.56418346
74	MYLK	0.52710705
75	MATK	0.52117155
76	CSK	0.52063393
77	PRKCE	0.50342340
78	PAK3	0.46425361
79	MAP3K2	0.44314269
80	ARAF	0.43674184
81	IGF1R	0.43567787
82	DAPK2	0.43201330
83	PIM2	0.42621156
84	TGFBR1	0.42555127
85	PRKACA	0.42350273
86	TAOK2	0.41485822
87	TYK2	0.39181347
88	NTRK2	0.38206242
89	MAP3K4	0.37848337
90	LCK	0.37058175
91	NME2	0.34931833
92	FES	0.34887643
93	CSNK1D	0.34643282
94	ABL1	0.33653513
95	OBSCN	0.32538650
96	MAP3K14	0.32045113
97	STK11	0.31102884
98	JAK1	0.30859442
99	PIM1	0.30313615
100	CSNK2A2	0.29801987

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.17951307
2	Allograft rejection_Homo sapiens_hsa05330	3.41092198
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.32809518
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.04133249
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.94413847
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.80975383
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.63003569
8	Ribosome_Homo sapiens_hsa03010	2.30344546
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.25891320
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.22119747
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.14691701
12	Homologous recombination_Homo sapiens_hsa03440	2.11098929
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.10984856
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.01261618
15	Butanoate metabolism_Homo sapiens_hsa00650	2.00473972
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.82698164
17	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.81444479
18	Phototransduction_Homo sapiens_hsa04744	1.77918380
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.77727336
20	Antigen processing and presentation_Homo sapiens_hsa04612	1.75212916
21	Retinol metabolism_Homo sapiens_hsa00830	1.42690649
22	RNA polymerase_Homo sapiens_hsa03020	1.42468116
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35400994
24	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.31595001
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31334575
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.28980050
27	Linoleic acid metabolism_Homo sapiens_hsa00591	1.27038012
28	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23992962
29	Proteasome_Homo sapiens_hsa03050	1.20306377
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14926184
31	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.14497164
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.12807455
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07571506
34	Protein export_Homo sapiens_hsa03060	1.05824557
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.04508699
36	Parkinsons disease_Homo sapiens_hsa05012	1.03845123
37	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.03438230
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98517090
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97791910
40	Olfactory transduction_Homo sapiens_hsa04740	0.96335792
41	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.94998380
42	Ether lipid metabolism_Homo sapiens_hsa00565	0.93461779
43	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90762972
44	Viral myocarditis_Homo sapiens_hsa05416	0.90129793
45	Propanoate metabolism_Homo sapiens_hsa00640	0.89821536
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86497215
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85263107
48	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85222845
49	Peroxisome_Homo sapiens_hsa04146	0.84932440
50	Nucleotide excision repair_Homo sapiens_hsa03420	0.84374666
51	Regulation of autophagy_Homo sapiens_hsa04140	0.83007149
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.82568841
53	Leishmaniasis_Homo sapiens_hsa05140	0.81284861
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81205914
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.81070193
56	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79720507
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75571349
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.74612465
59	Fatty acid elongation_Homo sapiens_hsa00062	0.73689608
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72228342
61	Purine metabolism_Homo sapiens_hsa00230	0.70928520
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69757185
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66932351
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61915615
65	One carbon pool by folate_Homo sapiens_hsa00670	0.60899980
66	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59420375
67	Huntingtons disease_Homo sapiens_hsa05016	0.57190212
68	Circadian rhythm_Homo sapiens_hsa04710	0.55439705
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55231053
70	Sulfur relay system_Homo sapiens_hsa04122	0.54690180
71	Mismatch repair_Homo sapiens_hsa03430	0.54686763
72	Alzheimers disease_Homo sapiens_hsa05010	0.54469370
73	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53397914
74	Basal transcription factors_Homo sapiens_hsa03022	0.52781880
75	RNA degradation_Homo sapiens_hsa03018	0.52514362
76	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.51927662
77	Renin-angiotensin system_Homo sapiens_hsa04614	0.50505765
78	Morphine addiction_Homo sapiens_hsa05032	0.48184219
79	Mineral absorption_Homo sapiens_hsa04978	0.47871598
80	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45426669
81	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.45097078
82	Salivary secretion_Homo sapiens_hsa04970	0.43315374
83	Malaria_Homo sapiens_hsa05144	0.42587380
84	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42533282
85	Caffeine metabolism_Homo sapiens_hsa00232	0.41035308
86	Fat digestion and absorption_Homo sapiens_hsa04975	0.40953480
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.40508189
88	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39699002
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.37579448
90	Tuberculosis_Homo sapiens_hsa05152	0.37454757
91	Metabolic pathways_Homo sapiens_hsa01100	0.36779883
92	Phagosome_Homo sapiens_hsa04145	0.35262319
93	African trypanosomiasis_Homo sapiens_hsa05143	0.35204235
94	Herpes simplex infection_Homo sapiens_hsa05168	0.32188585
95	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.31806104
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31357915
97	Serotonergic synapse_Homo sapiens_hsa04726	0.31069224
98	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.29309783
99	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29212792
100	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.28795124

EEF1DP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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