EEF1E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.26043324
2maturation of SSU-rRNA (GO:0030490)4.72325719
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.50011826
4negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.46795805
5ribosomal small subunit assembly (GO:0000028)4.41395801
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.38141759
7ribosomal small subunit biogenesis (GO:0042274)4.36099614
8purine nucleobase biosynthetic process (GO:0009113)4.33945962
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.32268207
10termination of RNA polymerase III transcription (GO:0006386)4.32268207
117-methylguanosine mRNA capping (GO:0006370)4.30734511
12positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.26811198
13nucleobase biosynthetic process (GO:0046112)4.26515291
14ribosomal large subunit biogenesis (GO:0042273)4.25629804
15RNA capping (GO:0036260)4.24281497
167-methylguanosine RNA capping (GO:0009452)4.24281497
17formation of translation preinitiation complex (GO:0001731)4.22172257
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.22148015
19respiratory electron transport chain (GO:0022904)4.20289013
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.19426223
21regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.19385969
22cullin deneddylation (GO:0010388)4.12920940
23ribonucleoprotein complex biogenesis (GO:0022613)4.12821033
24electron transport chain (GO:0022900)4.11272444
25negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.09517608
26negative regulation of ligase activity (GO:0051352)4.09517608
27DNA deamination (GO:0045006)4.09433034
28rRNA modification (GO:0000154)4.07185118
29ribosome biogenesis (GO:0042254)4.04123893
30protein deneddylation (GO:0000338)3.99453891
31viral transcription (GO:0019083)3.99048224
32ribosome assembly (GO:0042255)3.98232184
33translational termination (GO:0006415)3.97841265
34regulation of cellular amino acid metabolic process (GO:0006521)3.97159966
35chaperone-mediated protein transport (GO:0072321)3.95874544
36DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.89518028
37histone exchange (GO:0043486)3.89217553
38CENP-A containing nucleosome assembly (GO:0034080)3.87417226
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86755703
40ATP synthesis coupled proton transport (GO:0015986)3.86755703
41spliceosomal snRNP assembly (GO:0000387)3.86165088
42transcription elongation from RNA polymerase I promoter (GO:0006362)3.85401856
43rRNA processing (GO:0006364)3.85239014
44DNA strand elongation involved in DNA replication (GO:0006271)3.84978592
45DNA replication checkpoint (GO:0000076)3.84641928
46mitochondrial respiratory chain complex assembly (GO:0033108)3.83023724
47intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.83016118
48signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.83016118
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.81209851
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.81209851
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.81209851
52protein complex biogenesis (GO:0070271)3.80863616
53telomere maintenance via semi-conservative replication (GO:0032201)3.76498007
54signal transduction involved in DNA damage checkpoint (GO:0072422)3.75538241
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.75538241
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.73633398
57DNA replication initiation (GO:0006270)3.72726763
58chromatin remodeling at centromere (GO:0031055)3.72663449
59translational initiation (GO:0006413)3.71725806
60rRNA metabolic process (GO:0016072)3.71439550
61signal transduction involved in cell cycle checkpoint (GO:0072395)3.71217207
62termination of RNA polymerase I transcription (GO:0006363)3.69904918
63maturation of 5.8S rRNA (GO:0000460)3.67794035
64DNA strand elongation (GO:0022616)3.66178389
65pseudouridine synthesis (GO:0001522)3.65593848
66DNA double-strand break processing (GO:0000729)3.64903759
67NADH dehydrogenase complex assembly (GO:0010257)3.63933240
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63933240
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.63933240
70translational elongation (GO:0006414)3.62022096
71cellular component biogenesis (GO:0044085)3.59871386
72transcription-coupled nucleotide-excision repair (GO:0006283)3.58592764
73positive regulation of ligase activity (GO:0051351)3.57107349
74mitotic metaphase plate congression (GO:0007080)3.57048534
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54499381
76regulation of mitotic spindle checkpoint (GO:1903504)3.54499381
77transcription from RNA polymerase I promoter (GO:0006360)3.54195318
78respiratory chain complex IV assembly (GO:0008535)3.54136392
79protein neddylation (GO:0045116)3.53919516
80translation (GO:0006412)3.51633395
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50038724
82cotranslational protein targeting to membrane (GO:0006613)3.48258917
83establishment of integrated proviral latency (GO:0075713)3.45560169
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.45384634
85spliceosomal complex assembly (GO:0000245)3.45265306
86protein targeting to ER (GO:0045047)3.42046784
87kinetochore assembly (GO:0051382)3.40744123
88establishment of protein localization to mitochondrion (GO:0072655)3.39931046
89telomere maintenance via recombination (GO:0000722)3.38678624
90protein targeting to mitochondrion (GO:0006626)3.37260791
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37131674
92G1/S transition of mitotic cell cycle (GO:0000082)3.36964519
93cell cycle G1/S phase transition (GO:0044843)3.36964519
94DNA replication-independent nucleosome organization (GO:0034724)3.34779256
95DNA replication-independent nucleosome assembly (GO:0006336)3.34779256
96regulation of ubiquitin-protein transferase activity (GO:0051438)3.33639676
97cellular protein complex disassembly (GO:0043624)3.31133971
98rRNA methylation (GO:0031167)3.29796403
99IMP biosynthetic process (GO:0006188)3.29268725
100kinetochore organization (GO:0051383)3.29128408
101protein localization to endoplasmic reticulum (GO:0070972)3.28902814
102establishment of viral latency (GO:0019043)3.27542204
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27129726
104histone mRNA metabolic process (GO:0008334)3.26989798
105DNA catabolic process, exonucleolytic (GO:0000738)3.25652462
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24865792
107establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24726084
108cytochrome complex assembly (GO:0017004)3.23514464
109transcription elongation from RNA polymerase II promoter (GO:0006368)3.23219430
110deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23015153
111regulation of ligase activity (GO:0051340)3.21494622
112regulation of mitochondrial translation (GO:0070129)3.21031181
113transcription initiation from RNA polymerase I promoter (GO:0006361)3.20953005
114nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20462724
115DNA damage response, detection of DNA damage (GO:0042769)3.19771554
116antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.18846429
117viral life cycle (GO:0019058)3.17576324
118mitotic recombination (GO:0006312)3.16292164
119protein localization to kinetochore (GO:0034501)3.16244053
120protein localization to mitochondrion (GO:0070585)3.15728201
121negative regulation of DNA-dependent DNA replication (GO:2000104)3.13654499
122oxidative phosphorylation (GO:0006119)3.10024347
123tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09120460
124RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09120460
125inner mitochondrial membrane organization (GO:0007007)3.03827534
126metaphase plate congression (GO:0051310)3.03698552
127negative regulation of mitotic sister chromatid separation (GO:2000816)3.03531535
128negative regulation of sister chromatid segregation (GO:0033046)3.03531535
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03531535
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03531535
131negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03531535
132regulation of helicase activity (GO:0051095)3.02376577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.86052987
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.71331977
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55506835
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.08326560
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.03072344
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.91243742
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78852107
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.68400984
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.47336311
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38251509
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.28244232
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.21586876
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20647622
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18921950
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18814257
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.07526871
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.95127407
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84638519
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81560167
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.78213284
21VDR_23849224_ChIP-Seq_CD4+_Human2.70460781
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53484932
23XRN2_22483619_ChIP-Seq_HELA_Human2.45164142
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.42528584
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42337665
26DCP1A_22483619_ChIP-Seq_HELA_Human2.42312341
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29728123
28FOXP3_21729870_ChIP-Seq_TREG_Human2.26392400
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.24437618
30GABP_19822575_ChIP-Seq_HepG2_Human2.18499474
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.13064872
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10181480
33TTF2_22483619_ChIP-Seq_HELA_Human2.09930746
34* YY1_21170310_ChIP-Seq_MESCs_Mouse2.04556509
35ELK1_19687146_ChIP-ChIP_HELA_Human2.04424752
36SRF_21415370_ChIP-Seq_HL-1_Mouse2.03529388
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98091717
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97668950
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95028329
40* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90609553
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88905738
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88798477
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86058944
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85522519
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74000048
46AR_21909140_ChIP-Seq_LNCAP_Human1.71743969
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66743114
48VDR_22108803_ChIP-Seq_LS180_Human1.62996818
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60654848
50EWS_26573619_Chip-Seq_HEK293_Human1.57653405
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56255131
52FUS_26573619_Chip-Seq_HEK293_Human1.50356819
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47793305
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47516432
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46179071
56ZNF274_21170338_ChIP-Seq_K562_Hela1.42518456
57* E2F1_21310950_ChIP-Seq_MCF-7_Human1.41635953
58* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40793894
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36439730
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.34747719
61KDM5A_27292631_Chip-Seq_BREAST_Human1.33678136
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32878690
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.30778157
64CIITA_25753668_ChIP-Seq_RAJI_Human1.30481890
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29840655
66MYC_18940864_ChIP-ChIP_HL60_Human1.25151574
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24517476
68* NANOG_16153702_ChIP-ChIP_HESCs_Human1.23901971
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21208182
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20966086
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19073446
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16996676
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.13263043
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.10854537
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09843430
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09771731
77IGF1R_20145208_ChIP-Seq_DFB_Human1.09248973
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08716685
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06624304
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05058791
81* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03182209
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00037231
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99661187
84TAF15_26573619_Chip-Seq_HEK293_Human0.99307209
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98310841
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98173351
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95998901
88PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94807387
89* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94520277
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93101239
91KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92879375
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88240685
93HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87945895
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.86939869
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86538662
96P300_19829295_ChIP-Seq_ESCs_Human0.86194363
97TP63_19390658_ChIP-ChIP_HaCaT_Human0.86061623
98SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85620102
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.85581126
100* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85031333
101SOX17_20123909_ChIP-Seq_XEN_Mouse0.84524796
102IRF1_19129219_ChIP-ChIP_H3396_Human0.84297865
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82279812
104TFEB_21752829_ChIP-Seq_HELA_Human0.82043801
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80805871
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80312975
107TP53_22573176_ChIP-Seq_HFKS_Human0.78898441
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78386502
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77816002
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77374594
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75963977
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75721701
113* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75364044
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74434469
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74214131
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73762405
117NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.72921743
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72152324
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71512541
120CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71418937
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71184205
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70234674
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70015277
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69302444
125CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.68927170
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67565209
127CTBP1_25329375_ChIP-Seq_LNCAP_Human0.67079985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.62574793
2MP0004957_abnormal_blastocyst_morpholog4.60622248
3MP0010094_abnormal_chromosome_stability4.15909142
4MP0003111_abnormal_nucleus_morphology4.08050696
5MP0008057_abnormal_DNA_replication3.86222882
6MP0008058_abnormal_DNA_repair3.69903301
7* MP0003077_abnormal_cell_cycle3.60471129
8MP0008932_abnormal_embryonic_tissue3.06829837
9MP0003718_maternal_effect3.01943316
10MP0001529_abnormal_vocalization2.93070778
11MP0003123_paternal_imprinting2.71638110
12MP0003941_abnormal_skin_development2.49858133
13MP0003786_premature_aging2.49332889
14MP0008877_abnormal_DNA_methylation2.45949429
15MP0008007_abnormal_cellular_replicative2.42157804
16MP0009379_abnormal_foot_pigmentation1.93266673
17MP0001730_embryonic_growth_arrest1.92248424
18MP0006292_abnormal_olfactory_placode1.81567358
19MP0006035_abnormal_mitochondrial_morpho1.79213315
20MP0002102_abnormal_ear_morphology1.76550998
21* MP0000350_abnormal_cell_proliferation1.75344581
22MP0001905_abnormal_dopamine_level1.71826770
23MP0008260_abnormal_autophagy1.70925036
24MP0002396_abnormal_hematopoietic_system1.66648654
25MP0006036_abnormal_mitochondrial_physio1.60072886
26MP0003315_abnormal_perineum_morphology1.58102707
27MP0003806_abnormal_nucleotide_metabolis1.45707203
28MP0008995_early_reproductive_senescence1.45548308
29MP0002736_abnormal_nociception_after1.40536460
30MP0003121_genomic_imprinting1.37830972
31MP0002210_abnormal_sex_determination1.36257499
32MP0004147_increased_porphyrin_level1.35532165
33MP0001697_abnormal_embryo_size1.31894055
34MP0006276_abnormal_autonomic_nervous1.31234420
35MP0003186_abnormal_redox_activity1.31204496
36MP0005084_abnormal_gallbladder_morpholo1.30240537
37MP0002837_dystrophic_cardiac_calcinosis1.29240830
38MP0000490_abnormal_crypts_of1.29159508
39MP0000358_abnormal_cell_content/1.25178680
40MP0001188_hyperpigmentation1.23568789
41* MP0002080_prenatal_lethality1.22095615
42MP0000313_abnormal_cell_death1.20498661
43MP0001145_abnormal_male_reproductive1.18952359
44MP0001986_abnormal_taste_sensitivity1.17393985
45MP0005380_embryogenesis_phenotype1.14204933
46MP0001672_abnormal_embryogenesis/_devel1.14204933
47MP0005253_abnormal_eye_physiology1.12775813
48MP0002638_abnormal_pupillary_reflex1.11643800
49MP0003656_abnormal_erythrocyte_physiolo1.10426072
50MP0001929_abnormal_gametogenesis1.10341450
51MP0000631_abnormal_neuroendocrine_gland1.09218104
52MP0003011_delayed_dark_adaptation1.08899524
53MP0005408_hypopigmentation1.06827931
54MP0000653_abnormal_sex_gland1.06648190
55MP0003880_abnormal_central_pattern1.06558170
56MP0002938_white_spotting1.05725525
57MP0003136_yellow_coat_color1.05501167
58MP0003221_abnormal_cardiomyocyte_apopto1.04787276
59MP0001984_abnormal_olfaction1.04468489
60MP0002234_abnormal_pharynx_morphology1.02519678
61MP0002085_abnormal_embryonic_tissue1.01653587
62MP0002751_abnormal_autonomic_nervous1.00674940
63MP0002160_abnormal_reproductive_system0.99998946
64MP0002132_abnormal_respiratory_system0.99149062
65MP0003646_muscle_fatigue0.97577543
66MP0004215_abnormal_myocardial_fiber0.97360849
67MP0001286_abnormal_eye_development0.97238825
68MP0002163_abnormal_gland_morphology0.96823542
69MP0005551_abnormal_eye_electrophysiolog0.95399607
70MP0003567_abnormal_fetal_cardiomyocyte0.95165788
71MP0003195_calcinosis0.94407797
72MP0003984_embryonic_growth_retardation0.93590307
73MP0000049_abnormal_middle_ear0.91778403
74MP0008789_abnormal_olfactory_epithelium0.91492889
75MP0002088_abnormal_embryonic_growth/wei0.91031406
76MP0009046_muscle_twitch0.89720601
77MP0001727_abnormal_embryo_implantation0.89609979
78MP0002277_abnormal_respiratory_mucosa0.89261800
79MP0002090_abnormal_vision0.88926480
80MP0004142_abnormal_muscle_tone0.87464840
81* MP0002019_abnormal_tumor_incidence0.87409356
82MP0002233_abnormal_nose_morphology0.86860877
83MP0000647_abnormal_sebaceous_gland0.86743805
84MP0010030_abnormal_orbit_morphology0.86109631
85* MP0009333_abnormal_splenocyte_physiolog0.84564936
86MP0003890_abnormal_embryonic-extraembry0.83866528
87MP0005389_reproductive_system_phenotype0.83807822
88MP0003122_maternal_imprinting0.82795513
89MP0003119_abnormal_digestive_system0.82730379
90MP0002084_abnormal_developmental_patter0.80135818
91MP0001968_abnormal_touch/_nociception0.79128306
92MP0001485_abnormal_pinna_reflex0.78297516
93MP0009697_abnormal_copulation0.78127488
94MP0008875_abnormal_xenobiotic_pharmacok0.77372181
95MP0005266_abnormal_metabolism0.76260740
96MP0005379_endocrine/exocrine_gland_phen0.75861623
97MP0001119_abnormal_female_reproductive0.74569300
98MP0003938_abnormal_ear_development0.74514727
99MP0001293_anophthalmia0.71569242
100MP0005645_abnormal_hypothalamus_physiol0.71519044
101MP0003937_abnormal_limbs/digits/tail_de0.70942508
102MP0005499_abnormal_olfactory_system0.70850095
103MP0005394_taste/olfaction_phenotype0.70850095
104MP0003698_abnormal_male_reproductive0.70263098
105MP0005391_vision/eye_phenotype0.69884085
106MP0005395_other_phenotype0.69516889
107MP0008872_abnormal_physiological_respon0.69466845
108MP0001764_abnormal_homeostasis0.69266901
109MP0005423_abnormal_somatic_nervous0.69133616
110MP0009672_abnormal_birth_weight0.68844717
111MP0005384_cellular_phenotype0.67943105
112MP0005075_abnormal_melanosome_morpholog0.67726243
113MP0005332_abnormal_amino_acid0.67054435
114MP0003137_abnormal_impulse_conducting0.66658315
115MP0001542_abnormal_bone_strength0.66645337
116MP0002095_abnormal_skin_pigmentation0.66216987
117MP0002697_abnormal_eye_size0.66129769
118MP0000015_abnormal_ear_pigmentation0.66125959
119MP0010307_abnormal_tumor_latency0.65505171
120MP0000372_irregular_coat_pigmentation0.65435482
121MP0002086_abnormal_extraembryonic_tissu0.62155598
122MP0001545_abnormal_hematopoietic_system0.61509344
123MP0005397_hematopoietic_system_phenotyp0.61509344
124MP0002735_abnormal_chemical_nociception0.61431469
125MP0004197_abnormal_fetal_growth/weight/0.60924254
126MP0002161_abnormal_fertility/fecundity0.60287925
127MP0000689_abnormal_spleen_morphology0.60184029
128MP0004808_abnormal_hematopoietic_stem0.59807372
129MP0000703_abnormal_thymus_morphology0.59483610
130MP0004133_heterotaxia0.58528092
131MP0006072_abnormal_retinal_apoptosis0.58378733
132MP0002722_abnormal_immune_system0.57963632
133MP0003763_abnormal_thymus_physiology0.57419651

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.47339419
2Abnormality of cells of the erythroid lineage (HP:0012130)4.93038806
3Abnormal number of erythroid precursors (HP:0012131)4.63894071
4Acute necrotizing encephalopathy (HP:0006965)4.28301106
5Cerebral hypomyelination (HP:0006808)4.12536014
6Breast hypoplasia (HP:0003187)4.11566828
7Mitochondrial inheritance (HP:0001427)3.91727394
8Abnormal mitochondria in muscle tissue (HP:0008316)3.83134307
9Increased hepatocellular lipid droplets (HP:0006565)3.68769820
10Abnormality of glycolysis (HP:0004366)3.67218472
11Increased serum pyruvate (HP:0003542)3.67218472
12Increased CSF lactate (HP:0002490)3.67066044
13Reticulocytopenia (HP:0001896)3.58782891
14Progressive macrocephaly (HP:0004481)3.44749000
15Oral leukoplakia (HP:0002745)3.36263423
16Carpal bone hypoplasia (HP:0001498)3.35354242
173-Methylglutaconic aciduria (HP:0003535)3.35094113
18Hepatocellular necrosis (HP:0001404)3.33295961
19Rough bone trabeculation (HP:0100670)3.30089215
20Aplastic anemia (HP:0001915)3.28413836
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25319466
22Acute encephalopathy (HP:0006846)3.21343320
23Macrocytic anemia (HP:0001972)3.19547820
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13772828
25Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13772828
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.13348237
27Irregular epiphyses (HP:0010582)3.11808002
28Increased serum lactate (HP:0002151)3.09457418
29Abnormality of the labia minora (HP:0012880)3.04845663
30Patellar aplasia (HP:0006443)3.04183653
31Lipid accumulation in hepatocytes (HP:0006561)2.99946334
32Aplasia/Hypoplasia of the patella (HP:0006498)2.88689938
33Pallor (HP:0000980)2.81158234
34Methylmalonic acidemia (HP:0002912)2.75134602
35Abnormality of the anterior horn cell (HP:0006802)2.71284576
36Degeneration of anterior horn cells (HP:0002398)2.71284576
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.70222860
38Renal Fanconi syndrome (HP:0001994)2.68676358
39Exertional dyspnea (HP:0002875)2.65950466
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.65040639
41CNS hypomyelination (HP:0003429)2.62402757
42Abnormality of methionine metabolism (HP:0010901)2.62371202
43Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60898038
44Hepatic necrosis (HP:0002605)2.57177285
45Congenital, generalized hypertrichosis (HP:0004540)2.55863011
46Respiratory difficulties (HP:0002880)2.55197739
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.52729948
48Exercise intolerance (HP:0003546)2.49725389
49Abnormal trabecular bone morphology (HP:0100671)2.48299933
50Methylmalonic aciduria (HP:0012120)2.43684245
51Absent epiphyses (HP:0010577)2.42505645
52Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.42505645
53Secondary amenorrhea (HP:0000869)2.41016526
54Lactic acidosis (HP:0003128)2.39388324
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38133056
56Abnormality of alanine metabolism (HP:0010916)2.38133056
57Hyperalaninemia (HP:0003348)2.38133056
58Microvesicular hepatic steatosis (HP:0001414)2.36940468
59Premature graying of hair (HP:0002216)2.36098196
60Abnormality of serum amino acid levels (HP:0003112)2.31699700
61Increased intramyocellular lipid droplets (HP:0012240)2.29863739
62Respiratory failure (HP:0002878)2.28099112
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27446302
64Postnatal microcephaly (HP:0005484)2.26999526
65Absent radius (HP:0003974)2.26026360
66Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.24750635
67Abnormality of renal resorption (HP:0011038)2.24485569
68Megaloblastic anemia (HP:0001889)2.22532775
69Abnormality of the preputium (HP:0100587)2.22316430
70Lethargy (HP:0001254)2.22278080
71Type 2 muscle fiber atrophy (HP:0003554)2.21730556
72Small intestinal stenosis (HP:0012848)2.21015109
73Duodenal stenosis (HP:0100867)2.21015109
74Horseshoe kidney (HP:0000085)2.17911771
75Muscle fiber atrophy (HP:0100295)2.16358484
76Cellular immunodeficiency (HP:0005374)2.16199437
77Chromsome breakage (HP:0040012)2.14659058
78Leukodystrophy (HP:0002415)2.14639273
79Glossoptosis (HP:0000162)2.11754517
80Multiple enchondromatosis (HP:0005701)2.11646423
81Emotional lability (HP:0000712)2.11563795
82Septo-optic dysplasia (HP:0100842)2.11263718
83Increased muscle lipid content (HP:0009058)2.10845992
84Aplasia involving forearm bones (HP:0009822)2.10818327
85Absent forearm bone (HP:0003953)2.10818327
86Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10180060
87Delusions (HP:0000746)2.10001362
88Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09657404
89Pancreatic fibrosis (HP:0100732)2.09237475
90CNS demyelination (HP:0007305)2.09123413
91Colon cancer (HP:0003003)2.07450442
92Hyperglycinemia (HP:0002154)2.07422037
93Meckel diverticulum (HP:0002245)2.07327774
94Premature ovarian failure (HP:0008209)2.06719793
95Amniotic constriction ring (HP:0009775)2.03998318
96Abnormality of placental membranes (HP:0011409)2.03998318
97Unsteady gait (HP:0002317)2.03279338
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.03042472
99Absent thumb (HP:0009777)1.99675597
100Abnormality of the duodenum (HP:0002246)1.98366360
101Microretrognathia (HP:0000308)1.97462476
102Reduced antithrombin III activity (HP:0001976)1.97322224
103Impulsivity (HP:0100710)1.96566323
104Abnormality of midbrain morphology (HP:0002418)1.95903587
105Molar tooth sign on MRI (HP:0002419)1.95903587
106Abnormality of the ileum (HP:0001549)1.95563744
107Cerebral edema (HP:0002181)1.95288503
108Bone marrow hypocellularity (HP:0005528)1.94999194
109Type I transferrin isoform profile (HP:0003642)1.94113077
110Cleft eyelid (HP:0000625)1.93200877
111Abnormal glycosylation (HP:0012345)1.93019068
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93019068
113Abnormal protein N-linked glycosylation (HP:0012347)1.93019068
114Abnormal protein glycosylation (HP:0012346)1.93019068
115Poor head control (HP:0002421)1.91880290
116Abnormality of urine glucose concentration (HP:0011016)1.90088465
117Glycosuria (HP:0003076)1.90088465
118Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87950177
119Optic disc pallor (HP:0000543)1.87786835
120True hermaphroditism (HP:0010459)1.87686138
12111 pairs of ribs (HP:0000878)1.86877705
122Abnormality of homocysteine metabolism (HP:0010919)1.85131193
123Homocystinuria (HP:0002156)1.85131193
124Trismus (HP:0000211)1.81840571
125X-linked dominant inheritance (HP:0001423)1.81764897
126Sloping forehead (HP:0000340)1.81468552
127Pancytopenia (HP:0001876)1.81029811
128Triphalangeal thumb (HP:0001199)1.77818978
129Pancreatic cysts (HP:0001737)1.76063422
130Stenosis of the external auditory canal (HP:0000402)1.75988563
131Absent septum pellucidum (HP:0001331)1.75926736
132Abnormality of chromosome stability (HP:0003220)1.75239971
133Poor suck (HP:0002033)1.73694027
134Abnormal lung lobation (HP:0002101)1.73370521
135Myelodysplasia (HP:0002863)1.69831170
136Sclerocornea (HP:0000647)1.69658942
137Hypoplasia of the pons (HP:0012110)1.69304317
138Hyperphosphaturia (HP:0003109)1.68637149
139Volvulus (HP:0002580)1.68596751

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.00595262
2WEE14.04720627
3EIF2AK13.70642243
4VRK23.56819502
5STK163.42612448
6TSSK63.14976632
7SRPK13.08159930
8NME22.86178541
9CDC72.57317436
10EIF2AK32.37362505
11PLK42.29186901
12NME12.23038132
13TRIM282.21680279
14VRK12.16502019
15ACVR1B2.06612265
16NUAK11.97727151
17PNCK1.96582759
18BRSK21.91277952
19CCNB11.89476396
20WNK31.86924527
21PLK31.74677609
22MKNK11.68416550
23TESK21.66089531
24NEK11.63599224
25PLK11.63431422
26MAP4K21.55644767
27PIM21.54080912
28TAF11.52187510
29DYRK21.46868450
30TNIK1.43502773
31DYRK31.43219688
32TTK1.41007562
33BRSK11.35651843
34MKNK21.34122146
35AURKA1.28406890
36CDK81.26873460
37PBK1.22216119
38MARK11.20891409
39MAP3K121.20048245
40AURKB1.17008416
41BRAF1.14031218
42MAP2K71.11127177
43NEK21.09134247
44MST41.07888066
45TLK11.03842018
46CHEK21.03420539
47ATR1.01722659
48LIMK11.00888688
49EIF2AK21.00149550
50ARAF0.96741676
51CDK70.94702794
52GRK10.91142628
53ERBB30.90649634
54EPHA20.89245287
55ZAK0.88714344
56BCKDK0.86761447
57CASK0.83725200
58CSNK1G30.82901057
59RPS6KB20.80190481
60CSNK2A20.78749456
61BMPR1B0.78017948
62CSNK2A10.77908696
63OXSR10.77277512
64CHEK10.76401595
65FRK0.74106620
66PASK0.71196892
67CSNK1A1L0.70885925
68TGFBR10.69539250
69CDK190.69396636
70PLK20.68039032
71ABL20.65082017
72STK40.62619387
73AKT30.62576460
74MAPK130.62396164
75TESK10.62103994
76RPS6KA40.59714701
77PAK10.59415296
78MAP3K40.58600451
79PRKCI0.57997525
80MAP3K80.57674895
81INSRR0.57399890
82DAPK10.56508703
83WNK40.53678431
84PINK10.53115814
85STK390.52361291
86MINK10.51465075
87ALK0.51158074
88RPS6KA50.50566088
89SCYL20.50487115
90STK30.49752585
91CDK20.49575176
92CSNK1G10.49040324
93BCR0.48929430
94CDK180.47732160
95ATM0.46399750
96CDK11A0.45482911
97CDK140.45289000
98CDK150.44812451
99CDK10.44758122
100PDK30.44425852
101PDK40.44425852
102GRK70.44118307
103STK38L0.43328762
104MUSK0.42439730
105PAK40.42359787
106KDR0.41008744
107ADRBK20.36872806
108CSNK1G20.35693181
109FGFR10.35064621
110PIM10.34862972
111GRK50.34588758
112CDK40.34303156
113MAPKAPK50.33577626
114ERBB40.32512720
115YES10.31798007
116CLK10.30628488
117CSNK1E0.30594503
118CDK30.30423625
119CSNK1A10.30247519
120MAP3K110.30076797
121PRKDC0.28572453
122TEC0.28117499
123ILK0.27662801
124MYLK0.27574104
125STK240.27364977
126TAOK20.27217163
127PRKCG0.27176791
128TIE10.26044562
129RAF10.25509047
130PDK20.25210266

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.10495472
2RNA polymerase_Homo sapiens_hsa030204.43261689
3Ribosome_Homo sapiens_hsa030104.27727100
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.84222915
5DNA replication_Homo sapiens_hsa030303.81397948
6Mismatch repair_Homo sapiens_hsa034303.32537212
7Spliceosome_Homo sapiens_hsa030403.07592714
8RNA transport_Homo sapiens_hsa030132.86995528
9Pyrimidine metabolism_Homo sapiens_hsa002402.76759827
10Nucleotide excision repair_Homo sapiens_hsa034202.71679691
11Oxidative phosphorylation_Homo sapiens_hsa001902.67747869
12Parkinsons disease_Homo sapiens_hsa050122.48625941
13Homologous recombination_Homo sapiens_hsa034402.46926900
14Base excision repair_Homo sapiens_hsa034102.29082955
15Basal transcription factors_Homo sapiens_hsa030222.26711667
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.03029368
17Huntingtons disease_Homo sapiens_hsa050162.02601561
18Cell cycle_Homo sapiens_hsa041101.95831937
19RNA degradation_Homo sapiens_hsa030181.78330008
20Protein export_Homo sapiens_hsa030601.71965444
21Non-homologous end-joining_Homo sapiens_hsa034501.69113076
22Vitamin B6 metabolism_Homo sapiens_hsa007501.66215750
23Purine metabolism_Homo sapiens_hsa002301.65945876
24Fanconi anemia pathway_Homo sapiens_hsa034601.64957522
25One carbon pool by folate_Homo sapiens_hsa006701.64398682
26Alzheimers disease_Homo sapiens_hsa050101.49000803
27Propanoate metabolism_Homo sapiens_hsa006401.48115622
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33240882
29mRNA surveillance pathway_Homo sapiens_hsa030151.32246919
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31022687
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22741520
32Epstein-Barr virus infection_Homo sapiens_hsa051691.19675651
33p53 signaling pathway_Homo sapiens_hsa041151.09327911
34Fatty acid elongation_Homo sapiens_hsa000621.09304770
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06192428
36Selenocompound metabolism_Homo sapiens_hsa004501.00530734
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.92672672
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90362231
39Oocyte meiosis_Homo sapiens_hsa041140.88314798
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88232319
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86726458
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75866616
43Regulation of autophagy_Homo sapiens_hsa041400.75704554
44Folate biosynthesis_Homo sapiens_hsa007900.72113609
45Butanoate metabolism_Homo sapiens_hsa006500.71517212
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67100245
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66691561
48Pentose phosphate pathway_Homo sapiens_hsa000300.63361975
49Systemic lupus erythematosus_Homo sapiens_hsa053220.63267893
50Peroxisome_Homo sapiens_hsa041460.63045267
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62951891
52Collecting duct acid secretion_Homo sapiens_hsa049660.62907906
53Cardiac muscle contraction_Homo sapiens_hsa042600.62888025
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62271648
55Sulfur metabolism_Homo sapiens_hsa009200.61662164
56Glutathione metabolism_Homo sapiens_hsa004800.54040201
57Metabolic pathways_Homo sapiens_hsa011000.53324671
58Biosynthesis of amino acids_Homo sapiens_hsa012300.51983553
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51793926
60Sulfur relay system_Homo sapiens_hsa041220.48049171
61Vitamin digestion and absorption_Homo sapiens_hsa049770.47342934
62Tryptophan metabolism_Homo sapiens_hsa003800.46966563
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.44120003
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44032860
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43536011
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40963252
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40452130
68Viral carcinogenesis_Homo sapiens_hsa052030.39287618
69Chemical carcinogenesis_Homo sapiens_hsa052040.38860891
70Antigen processing and presentation_Homo sapiens_hsa046120.38600421
71Fatty acid metabolism_Homo sapiens_hsa012120.37889123
72Vibrio cholerae infection_Homo sapiens_hsa051100.37166155
73beta-Alanine metabolism_Homo sapiens_hsa004100.36935348
74Herpes simplex infection_Homo sapiens_hsa051680.36806262
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36532742
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36510770
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.36443936
78Allograft rejection_Homo sapiens_hsa053300.35023123
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.34968556
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34870805
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34137881
82Fatty acid degradation_Homo sapiens_hsa000710.33738788
83Carbon metabolism_Homo sapiens_hsa012000.32927032
84Retinol metabolism_Homo sapiens_hsa008300.32408424
85Alcoholism_Homo sapiens_hsa050340.32374615
86Nitrogen metabolism_Homo sapiens_hsa009100.32107695
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31735073
88Legionellosis_Homo sapiens_hsa051340.31389593
89Arachidonic acid metabolism_Homo sapiens_hsa005900.29027301
90Type I diabetes mellitus_Homo sapiens_hsa049400.28432231
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.27733085
92Caffeine metabolism_Homo sapiens_hsa002320.26952300
93Fructose and mannose metabolism_Homo sapiens_hsa000510.25599684
94Asthma_Homo sapiens_hsa053100.25349683
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24282644
96Tyrosine metabolism_Homo sapiens_hsa003500.23371630
97N-Glycan biosynthesis_Homo sapiens_hsa005100.22995362
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20238968
99Nicotine addiction_Homo sapiens_hsa050330.19421613
100Phagosome_Homo sapiens_hsa041450.18125913
101Olfactory transduction_Homo sapiens_hsa047400.17215585
102Graft-versus-host disease_Homo sapiens_hsa053320.17058459
103Rheumatoid arthritis_Homo sapiens_hsa053230.16307752
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.16216898
105Phototransduction_Homo sapiens_hsa047440.15641180
106Autoimmune thyroid disease_Homo sapiens_hsa053200.15514583
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15424534
108Fat digestion and absorption_Homo sapiens_hsa049750.13952667
109Synaptic vesicle cycle_Homo sapiens_hsa047210.13813333
110Taste transduction_Homo sapiens_hsa047420.13581556
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.13541153
112HTLV-I infection_Homo sapiens_hsa051660.13074265
113TGF-beta signaling pathway_Homo sapiens_hsa043500.12774459
114Steroid biosynthesis_Homo sapiens_hsa001000.12143628
115Pyruvate metabolism_Homo sapiens_hsa006200.11914791
116Ether lipid metabolism_Homo sapiens_hsa005650.10711024
117Linoleic acid metabolism_Homo sapiens_hsa005910.09927765
118Renin-angiotensin system_Homo sapiens_hsa046140.09009046
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.08311173
120Arginine and proline metabolism_Homo sapiens_hsa003300.07852789
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06823596
122Shigellosis_Homo sapiens_hsa051310.06215055
123Colorectal cancer_Homo sapiens_hsa052100.06107013
124Thyroid cancer_Homo sapiens_hsa052160.04708330
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04265910
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.02953237
127Hematopoietic cell lineage_Homo sapiens_hsa046400.02211743
128Primary immunodeficiency_Homo sapiens_hsa053400.02180944
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01782781
130Apoptosis_Homo sapiens_hsa042100.01727253
131HIF-1 signaling pathway_Homo sapiens_hsa040660.00798180
132Galactose metabolism_Homo sapiens_hsa000520.00462230

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