ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of inclusion body assembly (GO:0090084)	7.48301295
2	endothelial tube morphogenesis (GO:0061154)	7.37042426
3	morphogenesis of an endothelium (GO:0003159)	7.37042426
4	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	7.34897841
5	mRNA transcription from RNA polymerase II promoter (GO:0042789)	7.26962140
6	negative regulation of cell fate commitment (GO:0010454)	7.01864798
7	negative regulation of cell fate specification (GO:0009996)	6.62312567
8	mRNA transcription (GO:0009299)	6.28876250
9	regulation of transcription involved in cell fate commitment (GO:0060850)	6.25734952
10	protein refolding (GO:0042026)	6.24352708
11	glucosamine-containing compound catabolic process (GO:1901072)	6.22253696
12	embryonic heart tube development (GO:0035050)	6.16491712
13	synaptic transmission, cholinergic (GO:0007271)	5.27788102
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.19139990
15	endoderm formation (GO:0001706)	4.88876759
16	renal system development (GO:0072001)	4.67173549
17	regulation of mesoderm development (GO:2000380)	4.65446975
18	respiratory tube development (GO:0030323)	4.64184910
19	embryonic foregut morphogenesis (GO:0048617)	4.63903252
20	organ formation (GO:0048645)	4.55923701
21	lactate metabolic process (GO:0006089)	4.32981870
22	endothelium development (GO:0003158)	4.25917260
23	collecting duct development (GO:0072044)	4.25536925
24	cell migration involved in gastrulation (GO:0042074)	4.24972659
25	regulation of inclusion body assembly (GO:0090083)	4.18444769
26	positive regulation of skeletal muscle tissue development (GO:0048643)	4.14670365
27	rRNA methylation (GO:0031167)	3.91529006
28	metanephric tubule development (GO:0072170)	3.78330492
29	metanephric nephron tubule development (GO:0072234)	3.78330492
30	proteasome assembly (GO:0043248)	3.78060204
31	lung epithelium development (GO:0060428)	3.76527851
32	rRNA modification (GO:0000154)	3.72920032
33	kidney morphogenesis (GO:0060993)	3.51992313
34	mitochondrial RNA metabolic process (GO:0000959)	3.51081658
35	ubiquinone biosynthetic process (GO:0006744)	3.47749936
36	ubiquinone metabolic process (GO:0006743)	3.43288539
37	regulation of cell fate specification (GO:0042659)	3.33028275
38	metanephric nephron epithelium development (GO:0072243)	3.25251935
39	regulation of podosome assembly (GO:0071801)	3.24740132
40	regulation of cell fate commitment (GO:0010453)	3.24137539
41	GTP biosynthetic process (GO:0006183)	3.21269838
42	lens fiber cell development (GO:0070307)	3.18070215
43	negative regulation of embryonic development (GO:0045992)	3.16445200
44	lung morphogenesis (GO:0060425)	3.12460983
45	termination of RNA polymerase III transcription (GO:0006386)	3.06608811
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.06608811
47	central nervous system myelination (GO:0022010)	3.06269585
48	axon ensheathment in central nervous system (GO:0032291)	3.06269585
49	cellular ketone body metabolic process (GO:0046950)	3.04922239
50	cartilage morphogenesis (GO:0060536)	3.03390556
51	lung-associated mesenchyme development (GO:0060484)	3.01276854
52	heart process (GO:0003015)	3.01180987
53	heart contraction (GO:0060047)	3.01180987
54	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.00654325
55	type B pancreatic cell development (GO:0003323)	3.00571026
56	water-soluble vitamin biosynthetic process (GO:0042364)	2.98760204
57	righting reflex (GO:0060013)	2.97251531
58	cellular protein complex localization (GO:0034629)	2.96980294
59	metanephric epithelium development (GO:0072207)	2.96260275
60	DNA strand elongation involved in DNA replication (GO:0006271)	2.95635790
61	regulation of cell proliferation involved in kidney development (GO:1901722)	2.92890994
62	UTP biosynthetic process (GO:0006228)	2.91660949
63	intracellular protein transmembrane import (GO:0044743)	2.90259065
64	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.87035268
65	quinone biosynthetic process (GO:1901663)	2.85053927
66	regulation of immunoglobulin secretion (GO:0051023)	2.83282196
67	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.78502629
68	amino sugar catabolic process (GO:0046348)	2.77786890
69	inner mitochondrial membrane organization (GO:0007007)	2.77257302
70	apoptotic DNA fragmentation (GO:0006309)	2.76296097
71	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.73812373
72	DNA strand elongation (GO:0022616)	2.72557931
73	telomere maintenance via semi-conservative replication (GO:0032201)	2.72436399
74	positive regulation of endothelial cell differentiation (GO:0045603)	2.70364806
75	regulation of glomerulus development (GO:0090192)	2.70092855
76	termination of RNA polymerase I transcription (GO:0006363)	2.70059665
77	organelle disassembly (GO:1903008)	2.67903520
78	DNA damage response, detection of DNA damage (GO:0042769)	2.67534650
79	digestive tract morphogenesis (GO:0048546)	2.67220350
80	chaperone-mediated protein transport (GO:0072321)	2.66443918
81	ketone body metabolic process (GO:1902224)	2.64306870
82	regulation of mitochondrial translation (GO:0070129)	2.63821874
83	respiratory chain complex IV assembly (GO:0008535)	2.63640932
84	negative regulation of telomere maintenance (GO:0032205)	2.62348303
85	negative regulation of ligase activity (GO:0051352)	2.61478262
86	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.61478262
87	nonmotile primary cilium assembly (GO:0035058)	2.59575347
88	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.59054782
89	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.58371773
90	multicellular organism reproduction (GO:0032504)	2.57940889
91	regulation of translational fidelity (GO:0006450)	2.57868023
92	regulation of translational elongation (GO:0006448)	2.57470597
93	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.56931910
94	isotype switching (GO:0045190)	2.56931910
95	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.56931910
96	transcription-coupled nucleotide-excision repair (GO:0006283)	2.55398627
97	protein complex localization (GO:0031503)	2.55171231
98	protein heterotetramerization (GO:0051290)	2.54553770
99	positive regulation of ligase activity (GO:0051351)	2.54145048
100	negative regulation of T cell differentiation in thymus (GO:0033085)	2.52720930

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	6.51911697
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.42607146
3	E2F7_22180533_ChIP-Seq_HELA_Human	4.15363838
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.03899541
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.76358240
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.61147106
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.90077876
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.79794413
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.79125509
10	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.77882026
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.70075932
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.68630026
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.55595393
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.53386911
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.48082215
16	DCP1A_22483619_ChIP-Seq_HELA_Human	2.33400838
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.22416020
18	EWS_26573619_Chip-Seq_HEK293_Human	2.18635013
19	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.09829056
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03155623
21	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.02809238
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.00567042
23	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.00561971
24	FUS_26573619_Chip-Seq_HEK293_Human	1.96403528
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.84243670
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79196353
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77228927
28	ZNF274_21170338_ChIP-Seq_K562_Hela	1.76976581
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.76873565
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76800630
31	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.73911560
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.71707202
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.67388232
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.65383836
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.61479528
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.60719385
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59007137
38	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.58273655
39	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.56631818
40	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.55338408
41	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.54522098
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.54271301
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.52736153
44	VDR_22108803_ChIP-Seq_LS180_Human	1.52382805
45	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.52212643
46	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.49008690
47	KDM5A_27292631_Chip-Seq_BREAST_Human	1.46758972
48	AR_21909140_ChIP-Seq_LNCAP_Human	1.46314118
49	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46147026
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.43436687
51	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.40684938
52	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.40056440
53	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37188258
54	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.35648677
55	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.34158716
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.31590723
57	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.27920320
58	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.26956325
59	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.26794607
60	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.25587884
61	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.24234523
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23256489
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22901349
64	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22890585
65	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.20301638
66	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.17207714
67	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.16472065
68	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.14608945
69	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.14586989
70	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.14481584
71	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.14481584
72	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.14481584
73	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.10681710
74	GABP_19822575_ChIP-Seq_HepG2_Human	1.07432616
75	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.07394739
76	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.06274131
77	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06014010
78	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.05896637
79	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.04287032
80	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00656728
81	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.00619646
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.99305116
83	ELF5_23300383_ChIP-Seq_T47D_Human	0.97149768
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.94068599
85	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.90623492
86	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.90360654
87	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89708636
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.87574258
89	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.87502230
90	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.86970248
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.85986001
92	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.84199522
93	TCF4_22108803_ChIP-Seq_LS180_Human	0.83859283
94	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.82020994
95	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.81470919
96	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.77853509
97	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.76907766
98	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.74322641
99	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.72290170
100	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.72239423

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004233_abnormal_muscle_weight	6.66739771
2	MP0005084_abnormal_gallbladder_morpholo	5.20109911
3	MP0008007_abnormal_cellular_replicative	5.01310509
4	MP0002928_abnormal_bile_duct	4.07134367
5	MP0008058_abnormal_DNA_repair	4.00439828
6	MP0003943_abnormal_hepatobiliary_system	3.83520463
7	MP0005646_abnormal_pituitary_gland	3.82397976
8	MP0010094_abnormal_chromosome_stability	3.63298270
9	MP0001346_abnormal_lacrimal_gland	3.27163144
10	MP0008875_abnormal_xenobiotic_pharmacok	2.81915538
11	MP0002102_abnormal_ear_morphology	2.71772560
12	MP0004808_abnormal_hematopoietic_stem	2.29907044
13	MP0002653_abnormal_ependyma_morphology	2.12179867
14	MP0005248_abnormal_Harderian_gland	2.00378265
15	MP0002138_abnormal_hepatobiliary_system	1.97659585
16	MP0010030_abnormal_orbit_morphology	1.91905325
17	MP0003786_premature_aging	1.86644069
18	MP0003718_maternal_effect	1.81737309
19	MP0003806_abnormal_nucleotide_metabolis	1.76635285
20	MP0002269_muscular_atrophy	1.60657679
21	MP0003119_abnormal_digestive_system	1.60545718
22	MP0004142_abnormal_muscle_tone	1.56635865
23	MP0003077_abnormal_cell_cycle	1.53274597
24	MP0003693_abnormal_embryo_hatching	1.47797527
25	MP0002295_abnormal_pulmonary_circulatio	1.45838712
26	MP0003186_abnormal_redox_activity	1.44837644
27	MP0008995_early_reproductive_senescence	1.43363574
28	MP0000516_abnormal_urinary_system	1.41761206
29	MP0005367_renal/urinary_system_phenotyp	1.41761206
30	MP0008057_abnormal_DNA_replication	1.40404513
31	MP0003122_maternal_imprinting	1.33970138
32	MP0000465_gastrointestinal_hemorrhage	1.28810407
33	MP0008872_abnormal_physiological_respon	1.25470078
34	MP0001849_ear_inflammation	1.24620367
35	MP0003136_yellow_coat_color	1.21219332
36	MP0006035_abnormal_mitochondrial_morpho	1.16531925
37	MP0003121_genomic_imprinting	1.13974197
38	MP0002233_abnormal_nose_morphology	1.12841922
39	MP0009672_abnormal_birth_weight	1.11612213
40	MP0003123_paternal_imprinting	1.08514289
41	MP0003111_abnormal_nucleus_morphology	1.07755140
42	MP0004147_increased_porphyrin_level	1.04827422
43	MP0001348_abnormal_lacrimal_gland	1.01109535
44	MP0009840_abnormal_foam_cell	1.00755139
45	MP0001286_abnormal_eye_development	1.00382677
46	MP0001944_abnormal_pancreas_morphology	0.99953958
47	MP0006072_abnormal_retinal_apoptosis	0.96811075
48	MP0002697_abnormal_eye_size	0.95506971
49	MP0002249_abnormal_larynx_morphology	0.93532598
50	MP0010368_abnormal_lymphatic_system	0.92892280
51	MP0003195_calcinosis	0.92833832
52	MP0001986_abnormal_taste_sensitivity	0.91800608
53	MP0008932_abnormal_embryonic_tissue	0.89505270
54	MP0004742_abnormal_vestibular_system	0.82700216
55	MP0002938_white_spotting	0.82211752
56	MP0008789_abnormal_olfactory_epithelium	0.80096814
57	MP0004957_abnormal_blastocyst_morpholog	0.78316393
58	MP0000343_altered_response_to	0.78236238
59	MP0009703_decreased_birth_body	0.77419321
60	MP0000685_abnormal_immune_system	0.74964215
61	MP0003632_abnormal_nervous_system	0.74764071
62	MP0005408_hypopigmentation	0.74155740
63	MP0005551_abnormal_eye_electrophysiolog	0.72538155
64	MP0001529_abnormal_vocalization	0.72483507
65	MP0000647_abnormal_sebaceous_gland	0.72180485
66	MP0008877_abnormal_DNA_methylation	0.71406291
67	MP0003329_amyloid_beta_deposits	0.70878399
68	MP0005448_abnormal_energy_balance	0.68726885
69	MP0003937_abnormal_limbs/digits/tail_de	0.68692957
70	MP0001968_abnormal_touch/_nociception	0.68242725
71	MP0001984_abnormal_olfaction	0.68120152
72	MP0002092_abnormal_eye_morphology	0.66559875
73	MP0002090_abnormal_vision	0.66389235
74	MP0005391_vision/eye_phenotype	0.66200543
75	MP0001929_abnormal_gametogenesis	0.65976878
76	MP0002160_abnormal_reproductive_system	0.64194563
77	MP0002752_abnormal_somatic_nervous	0.64104130
78	MP0001293_anophthalmia	0.63953363
79	MP0001119_abnormal_female_reproductive	0.63326713
80	MP0005394_taste/olfaction_phenotype	0.62888985
81	MP0005499_abnormal_olfactory_system	0.62888985
82	MP0001919_abnormal_reproductive_system	0.62676745
83	MP0002229_neurodegeneration	0.62368931
84	MP0001502_abnormal_circadian_rhythm	0.62327030
85	MP0000313_abnormal_cell_death	0.61421650
86	MP0010307_abnormal_tumor_latency	0.61362765
87	MP0004885_abnormal_endolymph	0.61084646
88	MP0003283_abnormal_digestive_organ	0.61080525
89	MP0000026_abnormal_inner_ear	0.60459357
90	MP0002210_abnormal_sex_determination	0.60370662
91	MP0001764_abnormal_homeostasis	0.60048367
92	MP0001340_abnormal_eyelid_morphology	0.59800864
93	MP0001905_abnormal_dopamine_level	0.59231131
94	MP0003172_abnormal_lysosome_physiology	0.57520518
95	MP0001697_abnormal_embryo_size	0.57346891
96	MP0003191_abnormal_cellular_cholesterol	0.57209761
97	MP0001963_abnormal_hearing_physiology	0.57139206
98	MP0000015_abnormal_ear_pigmentation	0.56957735
99	MP0000613_abnormal_salivary_gland	0.56121344
100	MP0003699_abnormal_female_reproductive	0.55790469

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 2 muscle fiber atrophy (HP:0003554)	9.95305637
2	Muscle fiber atrophy (HP:0100295)	8.85825895
3	Fatigable weakness (HP:0003473)	6.65118717
4	Abnormality of the neuromuscular junction (HP:0003398)	6.65118717
5	Poor suck (HP:0002033)	6.14487351
6	Decreased muscle mass (HP:0003199)	5.47386634
7	Nonprogressive disorder (HP:0003680)	5.42428345
8	Weak cry (HP:0001612)	5.26324111
9	Easy fatigability (HP:0003388)	4.97662788
10	Hydroureter (HP:0000072)	4.15360892
11	High anterior hairline (HP:0009890)	4.01516056
12	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	3.52752452
13	True hermaphroditism (HP:0010459)	3.35046531
14	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	3.22683225
15	Bulbar palsy (HP:0001283)	3.16796531
16	Stomatitis (HP:0010280)	3.15505794
17	Abnormality of the columella (HP:0009929)	3.10865956
18	Fibular hypoplasia (HP:0003038)	3.02242519
19	Abnormality of the frontal sinuses (HP:0002687)	2.93637768
20	Short tibia (HP:0005736)	2.92270642
21	Median cleft lip (HP:0000161)	2.92091023
22	Menstrual irregularities (HP:0000858)	2.91658888
23	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.76148857
24	Dyschromatopsia (HP:0007641)	2.70096178
25	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.69610419
26	Increased IgM level (HP:0003496)	2.61217323
27	Type I transferrin isoform profile (HP:0003642)	2.61049999
28	Supernumerary spleens (HP:0009799)	2.57783603
29	Gonadotropin excess (HP:0000837)	2.56324595
30	Decreased central vision (HP:0007663)	2.55620139
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.53707928
32	Anophthalmia (HP:0000528)	2.51426115
33	Generalized muscle weakness (HP:0003324)	2.49224179
34	Abnormality of the incisor (HP:0000676)	2.47055550
35	Pancreatic cysts (HP:0001737)	2.45153471
36	Gowers sign (HP:0003391)	2.41417865
37	Abnormal respiratory motile cilium physiology (HP:0012261)	2.39257331
38	Pancreatic fibrosis (HP:0100732)	2.37027744
39	Oligodactyly (hands) (HP:0001180)	2.35486975
40	Abnormality of methionine metabolism (HP:0010901)	2.31818063
41	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.19300893
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.19300893
43	Abnormal protein glycosylation (HP:0012346)	2.19300893
44	Abnormal glycosylation (HP:0012345)	2.19300893
45	Hypoglycemic seizures (HP:0002173)	2.18643608
46	Esophageal atresia (HP:0002032)	2.11467636
47	Sclerocornea (HP:0000647)	2.09703735
48	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.03034110
49	Abnormal ciliary motility (HP:0012262)	2.02881040
50	Severe muscular hypotonia (HP:0006829)	2.01466752
51	Fibular aplasia (HP:0002990)	1.98701202
52	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.96463158
53	Abnormality of midbrain morphology (HP:0002418)	1.94982936
54	Molar tooth sign on MRI (HP:0002419)	1.94982936
55	Congenital, generalized hypertrichosis (HP:0004540)	1.94917980
56	Medial flaring of the eyebrow (HP:0010747)	1.89499412
57	Brushfield spots (HP:0001088)	1.87850545
58	Postaxial hand polydactyly (HP:0001162)	1.87311009
59	Poor coordination (HP:0002370)	1.85624017
60	Congenital primary aphakia (HP:0007707)	1.84447636
61	Scrotal hypoplasia (HP:0000046)	1.82272953
62	Nephronophthisis (HP:0000090)	1.78467229
63	Oligodactyly (HP:0012165)	1.76956468
64	Hyperinsulinemic hypoglycemia (HP:0000825)	1.74502169
65	Hepatic necrosis (HP:0002605)	1.74153923
66	Pendular nystagmus (HP:0012043)	1.73673038
67	Cystic liver disease (HP:0006706)	1.72699096
68	Multiple enchondromatosis (HP:0005701)	1.71965714
69	Adrenal hypoplasia (HP:0000835)	1.71516288
70	Hypobetalipoproteinemia (HP:0003563)	1.71180939
71	Postaxial foot polydactyly (HP:0001830)	1.71092520
72	Absent septum pellucidum (HP:0001331)	1.70677840
73	Microglossia (HP:0000171)	1.70583207
74	Abnormality of the septum pellucidum (HP:0007375)	1.68695150
75	Preauricular skin tag (HP:0000384)	1.66426859
76	Hypoglycemic coma (HP:0001325)	1.66077926
77	Gait imbalance (HP:0002141)	1.65568011
78	Anencephaly (HP:0002323)	1.65499121
79	Meckel diverticulum (HP:0002245)	1.65100734
80	Dyskinesia (HP:0100660)	1.64376056
81	Cutaneous melanoma (HP:0012056)	1.64150094
82	Benign neoplasm of the central nervous system (HP:0100835)	1.62591771
83	Delayed CNS myelination (HP:0002188)	1.62307646
84	Asplenia (HP:0001746)	1.61246686
85	Hepatocellular necrosis (HP:0001404)	1.60656892
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.59488682
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.59488682
88	Selective tooth agenesis (HP:0001592)	1.58911525
89	Acute necrotizing encephalopathy (HP:0006965)	1.58711830
90	Nephrogenic diabetes insipidus (HP:0009806)	1.57297279
91	Arthrogryposis multiplex congenita (HP:0002804)	1.55707375
92	Aplastic anemia (HP:0001915)	1.54710650
93	Increased CSF lactate (HP:0002490)	1.52895557
94	Broad nasal tip (HP:0000455)	1.52690689
95	Amniotic constriction ring (HP:0009775)	1.51768181
96	Abnormality of placental membranes (HP:0011409)	1.51768181
97	Broad foot (HP:0001769)	1.48291187
98	Bifid scrotum (HP:0000048)	1.47861547
99	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.47078019
100	Mitochondrial inheritance (HP:0001427)	1.46787003

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	4.13346012
2	PBK	2.48096661
3	MKNK2	2.33377085
4	TSSK6	12.0038808
5	TRIM28	1.99632494
6	MST4	1.95406107
7	VRK1	1.90783034
8	CASK	1.89898883
9	EIF2AK1	1.81537447
10	SRPK1	1.76639040
11	PRKD3	1.71033845
12	PDK2	1.66736277
13	ICK	1.63935914
14	ZAK	1.60957466
15	PNCK	1.54454411
16	BUB1	1.52359545
17	PLK3	1.48848479
18	TIE1	1.40039766
19	MAPKAPK3	1.34305216
20	MKNK1	1.33525491
21	PLK4	1.32487022
22	NUAK1	1.26668670
23	PAK4	1.21856007
24	EIF2AK3	1.20380835
25	BCR	1.12706366
26	NME1	1.12028637
27	VRK2	1.07711426
28	CDC7	1.02740908
29	WEE1	1.02543410
30	STK39	0.99045011
31	BRD4	0.97390029
32	BMPR1B	0.95721975
33	TAOK3	0.94271509
34	WNK4	0.89847303
35	PRKD2	0.87595248
36	NEK1	0.86477684
37	DMPK	0.83112153
38	TLK1	0.82368362
39	GRK1	0.78579589
40	MAPKAPK5	0.77658618
41	TTK	0.76976485
42	PINK1	0.71837823
43	RPS6KB2	0.71692088
44	PRKCH	0.71428013
45	STK38L	0.69982089
46	GRK7	0.68253594
47	CDK3	0.65755288
48	PLK1	0.58674835
49	ATR	0.57589364
50	SIK3	0.57093840
51	CAMK1D	0.53166115
52	CSNK1G1	0.51508382
53	OXSR1	0.50521592
54	STK16	0.49624330
55	MET	0.49044893
56	FRK	0.48956721
57	AURKB	0.46345101
58	ADRBK2	0.44149927
59	BCKDK	0.43836774
60	EIF2AK2	0.41665091
61	GSK3A	0.40312910
62	BMPR2	0.37190546
63	PLK2	0.36905064
64	ERBB3	0.36370017
65	CAMK1G	0.35296009
66	MAP2K2	0.35198891
67	CSNK1G3	0.34892026
68	MAPK13	0.33495517
69	CSNK2A1	0.32833294
70	ATM	0.31740935
71	MAP2K7	0.30325296
72	PRKCE	0.29996673
73	CAMKK2	0.28633583
74	TNIK	0.27642642
75	TGFBR1	0.27276082
76	CSNK1A1L	0.26759849
77	CSNK1G2	0.26447533
78	CSNK2A2	0.26136033
79	DAPK1	0.25901924
80	IRAK2	0.24614510
81	CDK7	0.24351199
82	TAF1	0.23559348
83	BRSK2	0.21938462
84	SCYL2	0.21344178
85	NTRK2	0.20275799
86	MST1R	0.20216629
87	ADRBK1	0.19568045
88	PIM2	0.19473515
89	NME2	0.19401450
90	FGFR1	0.19020034
91	PTK6	0.17827924
92	EPHA4	0.17533490
93	STK4	0.16635630
94	RPS6KA4	0.16543573
95	CSNK1E	0.16303873
96	RPS6KA5	0.15406299
97	PRKDC	0.14894391
98	MAP4K2	0.14883322
99	EPHA2	0.14752465
100	CHEK2	0.14577087

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.69691716
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.48916644
3	Proteasome_Homo sapiens_hsa03050	3.30481303
4	Mismatch repair_Homo sapiens_hsa03430	3.14410591
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.92960899
6	RNA polymerase_Homo sapiens_hsa03020	2.81659628
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.81440028
8	DNA replication_Homo sapiens_hsa03030	2.56171291
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.36502867
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.24251956
11	Legionellosis_Homo sapiens_hsa05134	2.22369614
12	Homologous recombination_Homo sapiens_hsa03440	2.20668252
13	Butanoate metabolism_Homo sapiens_hsa00650	2.17605860
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.08254051
15	Ribosome_Homo sapiens_hsa03010	2.06342690
16	One carbon pool by folate_Homo sapiens_hsa00670	1.96508729
17	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.95711253
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.94744927
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.86882378
20	Spliceosome_Homo sapiens_hsa03040	1.77341903
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.72258591
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.65626227
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61400600
24	Prion diseases_Homo sapiens_hsa05020	1.59343365
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.55122613
26	RNA transport_Homo sapiens_hsa03013	1.52676128
27	Peroxisome_Homo sapiens_hsa04146	1.48609509
28	RNA degradation_Homo sapiens_hsa03018	1.45157291
29	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.44183151
30	Parkinsons disease_Homo sapiens_hsa05012	1.42738135
31	Base excision repair_Homo sapiens_hsa03410	1.37454270
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.37380167
33	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.32567583
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25610422
35	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.23801032
36	Fatty acid elongation_Homo sapiens_hsa00062	1.20843290
37	Steroid biosynthesis_Homo sapiens_hsa00100	1.20808901
38	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.18051832
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.15853875
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12079264
41	Purine metabolism_Homo sapiens_hsa00230	1.07994654
42	Propanoate metabolism_Homo sapiens_hsa00640	1.05680079
43	Folate biosynthesis_Homo sapiens_hsa00790	1.05446666
44	Huntingtons disease_Homo sapiens_hsa05016	1.02547285
45	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.99929749
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.97596308
47	Basal transcription factors_Homo sapiens_hsa03022	0.92811768
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.92302939
49	Fatty acid degradation_Homo sapiens_hsa00071	0.92135691
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.88219782
51	Fatty acid metabolism_Homo sapiens_hsa01212	0.87770728
52	Caffeine metabolism_Homo sapiens_hsa00232	0.85706739
53	Glutathione metabolism_Homo sapiens_hsa00480	0.81877029
54	Pyruvate metabolism_Homo sapiens_hsa00620	0.80620663
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.79558423
56	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79364346
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77356549
58	Asthma_Homo sapiens_hsa05310	0.75530609
59	Wnt signaling pathway_Homo sapiens_hsa04310	0.70111223
60	Hippo signaling pathway_Homo sapiens_hsa04390	0.67701046
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66723110
62	Estrogen signaling pathway_Homo sapiens_hsa04915	0.64973994
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63401835
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.61433563
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61247737
66	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.60853166
67	p53 signaling pathway_Homo sapiens_hsa04115	0.59124328
68	Sulfur metabolism_Homo sapiens_hsa00920	0.57812502
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.54911411
70	Cell cycle_Homo sapiens_hsa04110	0.54392871
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.52847236
72	Arginine biosynthesis_Homo sapiens_hsa00220	0.52328729
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.50692804
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49257449
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.47249944
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.46984375
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46967759
78	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.46348458
79	Carbon metabolism_Homo sapiens_hsa01200	0.44156204
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.43930843
81	Metabolic pathways_Homo sapiens_hsa01100	0.43573131
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39715607
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.39150729
84	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.35762374
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.34757611
86	GABAergic synapse_Homo sapiens_hsa04727	0.33937098
87	Oocyte meiosis_Homo sapiens_hsa04114	0.33827184
88	Alzheimers disease_Homo sapiens_hsa05010	0.32530869
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.30801828
90	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.28241330
91	Olfactory transduction_Homo sapiens_hsa04740	0.27970651
92	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26860163
93	Collecting duct acid secretion_Homo sapiens_hsa04966	0.26548460
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26376458
95	Allograft rejection_Homo sapiens_hsa05330	0.24785174
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.23282947
97	Cocaine addiction_Homo sapiens_hsa05030	0.21732139
98	Phototransduction_Homo sapiens_hsa04744	0.21033982
99	Measles_Homo sapiens_hsa05162	0.19300235
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.17126134

EEF1E1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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