ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.52541424
2	regulation of mitotic spindle checkpoint (GO:1903504)	4.07635320
3	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.07635320
4	protein deneddylation (GO:0000338)	3.96211658
5	cullin deneddylation (GO:0010388)	3.93464892
6	ATP synthesis coupled proton transport (GO:0015986)	3.86803994
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.86803994
8	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.73860260
9	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.70352451
10	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.70352451
11	isotype switching (GO:0045190)	3.70352451
12	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.64606841
13	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.62750244
14	protein neddylation (GO:0045116)	3.57299682
15	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.48344601
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.48344601
17	proteasome assembly (GO:0043248)	3.47813970
18	ribosomal small subunit assembly (GO:0000028)	3.40761785
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.36233943
20	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.32826810
21	termination of RNA polymerase III transcription (GO:0006386)	3.32826810
22	chaperone-mediated protein transport (GO:0072321)	3.31936531
23	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.30270727
24	cellular response to interleukin-15 (GO:0071350)	3.26672466
25	rRNA modification (GO:0000154)	3.26219305
26	L-fucose catabolic process (GO:0042355)	3.24660385
27	fucose catabolic process (GO:0019317)	3.24660385
28	L-fucose metabolic process (GO:0042354)	3.24660385
29	preassembly of GPI anchor in ER membrane (GO:0016254)	3.23410408
30	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.22041161
31	protein-cofactor linkage (GO:0018065)	3.15387802
32	respiratory chain complex IV assembly (GO:0008535)	3.13390071
33	ribosomal large subunit biogenesis (GO:0042273)	3.09029854
34	maturation of 5.8S rRNA (GO:0000460)	3.08484003
35	regulation of cellular amino acid metabolic process (GO:0006521)	3.02580831
36	DNA catabolic process, exonucleolytic (GO:0000738)	2.99017391
37	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.98157545
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.97121880
39	GPI anchor metabolic process (GO:0006505)	2.96996328
40	DNA double-strand break processing (GO:0000729)	2.96363767
41	DNA damage response, detection of DNA damage (GO:0042769)	2.96044674
42	ribosome assembly (GO:0042255)	2.95581705
43	tRNA processing (GO:0008033)	2.95471853
44	mannosylation (GO:0097502)	2.93636516
45	GPI anchor biosynthetic process (GO:0006506)	2.93393183
46	protein complex biogenesis (GO:0070271)	2.91864204
47	platelet dense granule organization (GO:0060155)	2.91777186
48	somatic diversification of immunoglobulins (GO:0016445)	2.87877595
49	pseudouridine synthesis (GO:0001522)	2.87597811
50	positive regulation of prostaglandin secretion (GO:0032308)	2.86157480
51	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85975904
52	chromatin remodeling at centromere (GO:0031055)	2.85713245
53	positive regulation of T-helper 1 type immune response (GO:0002827)	2.85694261
54	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.84658996
55	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.84658996
56	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.84658996
57	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.84279898
58	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.83688491
59	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.83688491
60	NADH dehydrogenase complex assembly (GO:0010257)	2.83688491
61	branched-chain amino acid catabolic process (GO:0009083)	2.82568530
62	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.79803401
63	GMP metabolic process (GO:0046037)	2.78612281
64	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.77925896
65	CENP-A containing nucleosome assembly (GO:0034080)	2.76486371
66	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.75259531
67	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.74398137
68	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.74398137
69	rRNA catabolic process (GO:0016075)	2.73808924
70	sleep (GO:0030431)	2.73384609
71	tRNA metabolic process (GO:0006399)	2.72191205
72	peptidyl-histidine modification (GO:0018202)	2.72126913
73	maturation of SSU-rRNA (GO:0030490)	2.70219330
74	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.67434312
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.67434312
76	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.67201734
77	positive regulation of defense response to virus by host (GO:0002230)	2.66989762
78	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.66335788
79	cytochrome complex assembly (GO:0017004)	2.65684913
80	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.65614245
81	base-excision repair, AP site formation (GO:0006285)	2.65320994
82	spliceosomal snRNP assembly (GO:0000387)	2.65152779
83	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.65122008
84	rRNA methylation (GO:0031167)	2.64288805
85	water-soluble vitamin biosynthetic process (GO:0042364)	2.63011401
86	somatic diversification of immune receptors (GO:0002200)	2.62281434
87	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.62177401
88	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.61079738
89	negative regulation of ligase activity (GO:0051352)	2.60150302
90	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.60150302
91	metallo-sulfur cluster assembly (GO:0031163)	2.59151469
92	iron-sulfur cluster assembly (GO:0016226)	2.59151469
93	translation (GO:0006412)	2.56483197
94	mitochondrial RNA metabolic process (GO:0000959)	2.54648581
95	inner mitochondrial membrane organization (GO:0007007)	2.54356376
96	somatic cell DNA recombination (GO:0016444)	2.54327042
97	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.54327042
98	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.54038916
99	rRNA metabolic process (GO:0016072)	2.53670797
100	termination of RNA polymerase I transcription (GO:0006363)	2.53400270

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.66590379
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.62001785
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.97697915
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.37618826
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.26107234
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.24557886
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.10937980
8	VDR_23849224_ChIP-Seq_CD4+_Human	3.09211254
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.97379762
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.82309430
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.77938691
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.70611471
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.65154914
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.64154228
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.58469161
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.52182311
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.49012170
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.30617356
19	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.26812461
20	MYC_18940864_ChIP-ChIP_HL60_Human	2.14860799
21	VDR_22108803_ChIP-Seq_LS180_Human	2.11398394
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.07329842
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06191258
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.05655244
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.03692884
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.89247715
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.89103673
28	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.85932723
29	EWS_26573619_Chip-Seq_HEK293_Human	1.78900368
30	IRF1_19129219_ChIP-ChIP_H3396_Human	1.77456413
31	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.73778832
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.70339340
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.69403755
34	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.67480059
35	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.67211944
36	GABP_19822575_ChIP-Seq_HepG2_Human	1.60120158
37	DCP1A_22483619_ChIP-Seq_HELA_Human	1.60027878
38	TTF2_22483619_ChIP-Seq_HELA_Human	1.59714420
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57796291
40	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.56311598
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.53496859
42	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.52101847
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.51315405
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.49360606
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.46650722
46	FUS_26573619_Chip-Seq_HEK293_Human	1.40708871
47	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.39716653
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36348718
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.32327018
50	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.28725701
51	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.28071507
52	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.27454994
53	XRN2_22483619_ChIP-Seq_HELA_Human	1.25760162
54	TAF15_26573619_Chip-Seq_HEK293_Human	1.21942610
55	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.20769616
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20758181
57	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20758181
58	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19387658
59	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.17992733
60	AR_20517297_ChIP-Seq_VCAP_Human	1.17572032
61	GATA3_26560356_Chip-Seq_TH2_Human	1.15895417
62	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.15324748
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15269432
64	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.15046779
65	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.14359649
66	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12609107
67	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11623922
68	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.11000328
69	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.10046713
70	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.09700620
71	P300_19829295_ChIP-Seq_ESCs_Human	1.09252999
72	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.06821930
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06417865
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05928479
75	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.05039487
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04736051
77	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02772839
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02648210
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02648210
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02507291
81	ER_23166858_ChIP-Seq_MCF-7_Human	1.00078254
82	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.99598950
83	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.98351091
84	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.97986115
85	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.97725696
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97413049
87	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96576489
88	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95948900
89	CIITA_25753668_ChIP-Seq_RAJI_Human	0.93007029
90	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92810450
91	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.92068048
92	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91820264
93	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.91365329
94	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.89820042
95	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.88856159
96	MYB_26560356_Chip-Seq_TH2_Human	0.86345148
97	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.86257092
98	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.85813222
99	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.85185583
100	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.85075713

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005075_abnormal_melanosome_morpholog	3.43462849
2	MP0005671_abnormal_response_to	3.30121808
3	MP0002102_abnormal_ear_morphology	3.28076061
4	MP0006072_abnormal_retinal_apoptosis	3.27998994
5	MP0008877_abnormal_DNA_methylation	3.06746587
6	MP0004147_increased_porphyrin_level	3.04174098
7	MP0008058_abnormal_DNA_repair	2.59026802
8	MP0003011_delayed_dark_adaptation	2.31691006
9	MP0003786_premature_aging	2.23087584
10	MP0000372_irregular_coat_pigmentation	2.13282332
11	MP0003724_increased_susceptibility_to	2.04755173
12	MP0001835_abnormal_antigen_presentation	2.03822609
13	MP0002736_abnormal_nociception_after	2.02927525
14	MP0010094_abnormal_chromosome_stability	1.99952627
15	MP0008995_early_reproductive_senescence	1.95588228
16	MP0000685_abnormal_immune_system	1.86698363
17	MP0008872_abnormal_physiological_respon	1.86215459
18	MP0005253_abnormal_eye_physiology	1.83313205
19	MP0006292_abnormal_olfactory_placode	1.82763460
20	MP0001986_abnormal_taste_sensitivity	1.68347168
21	MP0003787_abnormal_imprinting	1.63609101
22	MP0004885_abnormal_endolymph	1.62815792
23	MP0002254_reproductive_system_inflammat	1.62117770
24	MP0002148_abnormal_hypersensitivity_rea	1.56844626
25	MP0003195_calcinosis	1.54252647
26	MP0005551_abnormal_eye_electrophysiolog	1.51672866
27	MP0003693_abnormal_embryo_hatching	1.51189755
28	MP0002006_tumorigenesis	1.51157816
29	MP0005084_abnormal_gallbladder_morpholo	1.51003637
30	MP0000465_gastrointestinal_hemorrhage	1.49321899
31	MP0005000_abnormal_immune_tolerance	1.48563426
32	MP0005377_hearing/vestibular/ear_phenot	1.48092807
33	MP0003878_abnormal_ear_physiology	1.48092807
34	MP0002009_preneoplasia	1.46871387
35	MP0009785_altered_susceptibility_to	1.46787215
36	MP0001800_abnormal_humoral_immune	1.46198277
37	MP0001293_anophthalmia	1.44284572
38	MP0002876_abnormal_thyroid_physiology	1.42342331
39	MP0001968_abnormal_touch/_nociception	1.41694506
40	MP0003763_abnormal_thymus_physiology	1.40406225
41	MP0005646_abnormal_pituitary_gland	1.37784239
42	MP0002938_white_spotting	1.37583738
43	MP0002166_altered_tumor_susceptibility	1.34818346
44	MP0004957_abnormal_blastocyst_morpholog	1.29423119
45	MP0006035_abnormal_mitochondrial_morpho	1.25219595
46	MP0006036_abnormal_mitochondrial_physio	1.24438619
47	MP0001529_abnormal_vocalization	1.24062980
48	MP0002138_abnormal_hepatobiliary_system	1.23594751
49	MP0002723_abnormal_immune_serum	1.22722646
50	MP0001873_stomach_inflammation	1.22384649
51	MP0008875_abnormal_xenobiotic_pharmacok	1.21946526
52	MP0004142_abnormal_muscle_tone	1.21454736
53	MP0002751_abnormal_autonomic_nervous	1.18719490
54	MP0001790_abnormal_immune_system	1.16198816
55	MP0005387_immune_system_phenotype	1.16198816
56	MP0003718_maternal_effect	1.15919326
57	MP0003436_decreased_susceptibility_to	1.12630361
58	MP0005645_abnormal_hypothalamus_physiol	1.09587011
59	MP0003567_abnormal_fetal_cardiomyocyte	1.08106446
60	MP0001819_abnormal_immune_cell	1.07446072
61	MP0000689_abnormal_spleen_morphology	1.05177219
62	MP0002420_abnormal_adaptive_immunity	1.04432628
63	MP0002234_abnormal_pharynx_morphology	1.03015390
64	MP0002452_abnormal_antigen_presenting	1.02614484
65	MP0002163_abnormal_gland_morphology	1.00164000
66	MP0001919_abnormal_reproductive_system	0.99418997
67	MP0003186_abnormal_redox_activity	0.97822593
68	MP0001501_abnormal_sleep_pattern	0.97483190
69	MP0004145_abnormal_muscle_electrophysio	0.96250671
70	MP0003866_abnormal_defecation	0.95401683
71	MP0003111_abnormal_nucleus_morphology	0.94770504
72	MP0001188_hyperpigmentation	0.89106489
73	MP0010155_abnormal_intestine_physiology	0.88952372
74	MP0002837_dystrophic_cardiac_calcinosis	0.87819665
75	MP0000703_abnormal_thymus_morphology	0.87690277
76	MP0003119_abnormal_digestive_system	0.87098545
77	MP0002933_joint_inflammation	0.86572086
78	MP0008007_abnormal_cellular_replicative	0.85042887
79	MP0002398_abnormal_bone_marrow	0.84894492
80	MP0009764_decreased_sensitivity_to	0.83929213
81	MP0003806_abnormal_nucleotide_metabolis	0.83515382
82	MP0009333_abnormal_splenocyte_physiolog	0.82077852
83	MP0002722_abnormal_immune_system	0.81754214
84	MP0002277_abnormal_respiratory_mucosa	0.80820769
85	MP0002405_respiratory_system_inflammati	0.80818740
86	MP0001984_abnormal_olfaction	0.80161801
87	MP0004133_heterotaxia	0.80069967
88	MP0003121_genomic_imprinting	0.79545756
89	MP0000716_abnormal_immune_system	0.78257495
90	MP0000427_abnormal_hair_cycle	0.77834400
91	MP0001119_abnormal_female_reproductive	0.76770704
92	MP0005389_reproductive_system_phenotype	0.76185143
93	MP0005332_abnormal_amino_acid	0.75871607
94	MP0001764_abnormal_homeostasis	0.75025399
95	MP0005379_endocrine/exocrine_gland_phen	0.74134283
96	MP0003937_abnormal_limbs/digits/tail_de	0.73127904
97	MP0003646_muscle_fatigue	0.72717593
98	MP0001929_abnormal_gametogenesis	0.72409660
99	MP0000647_abnormal_sebaceous_gland	0.71561891
100	MP0001845_abnormal_inflammatory_respons	0.70206195

Predicted human phenotypes

Rank	Gene Set	Z-score
1	IgG deficiency (HP:0004315)	4.12404906
2	Acute necrotizing encephalopathy (HP:0006965)	3.37599653
3	Mitochondrial inheritance (HP:0001427)	3.32768280
4	Increased hepatocellular lipid droplets (HP:0006565)	3.29477850
5	Increased CSF lactate (HP:0002490)	3.27307645
6	Acute encephalopathy (HP:0006846)	3.19643813
7	Lipid accumulation in hepatocytes (HP:0006561)	3.19282222
8	3-Methylglutaconic aciduria (HP:0003535)	3.09290913
9	Pancreatic cysts (HP:0001737)	3.04839230
10	Hepatocellular necrosis (HP:0001404)	3.04767286
11	Abnormal mitochondria in muscle tissue (HP:0008316)	2.97691286
12	Methylmalonic acidemia (HP:0002912)	2.87829818
13	Severe combined immunodeficiency (HP:0004430)	2.85018016
14	Hepatic necrosis (HP:0002605)	2.83340679
15	Abolished electroretinogram (ERG) (HP:0000550)	2.80114950
16	Renal cortical cysts (HP:0000803)	2.79409354
17	Progressive macrocephaly (HP:0004481)	2.71633892
18	Congenital, generalized hypertrichosis (HP:0004540)	2.68307421
19	Molar tooth sign on MRI (HP:0002419)	2.66570525
20	Abnormality of midbrain morphology (HP:0002418)	2.66570525
21	Nephronophthisis (HP:0000090)	2.60715993
22	Abnormality of the labia minora (HP:0012880)	2.59217276
23	Increased serum lactate (HP:0002151)	2.53598182
24	Abnormality of the renal cortex (HP:0011035)	2.49680734
25	Type I transferrin isoform profile (HP:0003642)	2.49536067
26	Congenital stationary night blindness (HP:0007642)	2.43129295
27	Hyperglycinuria (HP:0003108)	2.39264242
28	Cerebral edema (HP:0002181)	2.38738781
29	Lactic acidosis (HP:0003128)	2.35952645
30	Pancreatic fibrosis (HP:0100732)	2.35896541
31	Methylmalonic aciduria (HP:0012120)	2.27327549
32	Abnormal number of erythroid precursors (HP:0012131)	2.26973104
33	Hyperglycinemia (HP:0002154)	2.26324867
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.26111960
35	Stomatitis (HP:0010280)	2.24920162
36	Abnormality of alanine metabolism (HP:0010916)	2.24017440
37	Hyperalaninemia (HP:0003348)	2.24017440
38	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24017440
39	Abnormality of the pons (HP:0007361)	2.23906893
40	Increased intramyocellular lipid droplets (HP:0012240)	2.22471631
41	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.21947569
42	Abnormal protein N-linked glycosylation (HP:0012347)	2.21947569
43	Abnormal protein glycosylation (HP:0012346)	2.21947569
44	Abnormal glycosylation (HP:0012345)	2.21947569
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.21929614
46	Combined immunodeficiency (HP:0005387)	2.21695738
47	Reticulocytopenia (HP:0001896)	2.21242018
48	Abnormality of glycine metabolism (HP:0010895)	2.19889718
49	Abnormality of serine family amino acid metabolism (HP:0010894)	2.19889718
50	Renal Fanconi syndrome (HP:0001994)	2.19199213
51	Optic disc pallor (HP:0000543)	2.18349452
52	True hermaphroditism (HP:0010459)	2.16126808
53	Abnormality of eosinophils (HP:0001879)	2.15621738
54	Attenuation of retinal blood vessels (HP:0007843)	2.15415627
55	Type II lissencephaly (HP:0007260)	2.14747786
56	Abnormality of serum amino acid levels (HP:0003112)	2.14389691
57	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.14045228
58	Bile duct proliferation (HP:0001408)	2.13147621
59	Abnormal biliary tract physiology (HP:0012439)	2.13147621
60	Stomach cancer (HP:0012126)	2.12565100
61	Retrobulbar optic neuritis (HP:0100654)	2.12088137
62	Optic neuritis (HP:0100653)	2.12088137
63	Thyroiditis (HP:0100646)	2.11296468
64	Colon cancer (HP:0003003)	2.11155160
65	Medial flaring of the eyebrow (HP:0010747)	2.09035109
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.06983637
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.06983637
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.06639255
69	Absent thumb (HP:0009777)	2.06225603
70	Abnormality of the renal medulla (HP:0100957)	2.06125829
71	Abnormality of T cell number (HP:0011839)	2.05130147
72	Pancytopenia (HP:0001876)	2.04876024
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.04731948
74	Short tibia (HP:0005736)	2.03737353
75	T lymphocytopenia (HP:0005403)	2.03124408
76	Abnormality of cells of the erythroid lineage (HP:0012130)	2.02613884
77	Hypoplasia of the pons (HP:0012110)	2.01447764
78	Lethargy (HP:0001254)	2.00302433
79	IgM deficiency (HP:0002850)	2.00110231
80	Brittle hair (HP:0002299)	1.97762220
81	Abnormality of the ileum (HP:0001549)	1.96896883
82	Duplicated collecting system (HP:0000081)	1.96019673
83	Asplenia (HP:0001746)	1.94425687
84	Meckel diverticulum (HP:0002245)	1.94006565
85	Exertional dyspnea (HP:0002875)	1.92747255
86	Abnormality of T cells (HP:0002843)	1.91805189
87	Abnormality of the prostate (HP:0008775)	1.90710637
88	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90474000
89	Type 2 muscle fiber atrophy (HP:0003554)	1.90466634
90	Increased muscle lipid content (HP:0009058)	1.83262995
91	Abnormality of the renal collecting system (HP:0004742)	1.83123941
92	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.82156334
93	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.81349718
94	Progressive inability to walk (HP:0002505)	1.79502849
95	Hypoproteinemia (HP:0003075)	1.78454794
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.77725579
97	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.76525415
98	Myositis (HP:0100614)	1.76234946
99	Pendular nystagmus (HP:0012043)	1.75532484
100	Prostate neoplasm (HP:0100787)	1.75153585

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.86885453
2	MAP4K2	3.25697087
3	ZAK	3.08557629
4	NUAK1	2.78006698
5	TLK1	2.68470674
6	VRK2	2.64573389
7	TRIM28	2.58170160
8	TAOK3	2.29124607
9	TSSK6	2.28880282
10	SRPK1	2.10954190
11	PASK	2.08438070
12	MST4	2.05036804
13	BCKDK	1.97945014
14	ACVR1B	1.97743307
15	WNK3	1.82045609
16	CDK19	1.75936372
17	GRK1	1.75522158
18	EIF2AK3	1.74626132
19	GRK6	1.71186942
20	MKNK1	1.65070692
21	ERBB3	1.58991512
22	BCR	1.57834199
23	MAP2K2	1.54524455
24	BUB1	1.53647741
25	ADRBK2	1.48168329
26	MKNK2	1.41761385
27	NEK1	1.40803479
28	OXSR1	1.36700875
29	PLK3	1.34971401
30	TIE1	1.30248957
31	VRK1	1.30199079
32	IKBKB	1.28414010
33	MAP3K14	1.26510688
34	EIF2AK2	1.23265968
35	FES	1.21669977
36	RPS6KA4	1.21302213
37	PLK4	1.20653476
38	MAP3K4	1.17110254
39	PINK1	1.12320322
40	STK16	1.12167859
41	MAPKAPK3	1.05816993
42	KIT	1.04497469
43	BMPR1B	1.04093575
44	TGFBR1	0.99970711
45	IKBKE	0.95958679
46	CSNK1G3	0.95660410
47	EIF2AK1	0.94133990
48	NME1	0.92521395
49	STK39	0.91148105
50	FLT3	0.89534199
51	WNK4	0.88827486
52	CSNK1G2	0.88718257
53	CSNK1G1	0.86867009
54	SIK3	0.81097842
55	CDC7	0.81040587
56	FRK	0.80789903
57	MATK	0.80449565
58	TEC	0.80069579
59	DAPK1	0.79183426
60	TAF1	0.78168331
61	TTK	0.77969083
62	MAP4K1	0.76366180
63	ATR	0.71886765
64	BMPR2	0.70065326
65	CSNK1A1L	0.69545907
66	MAP3K12	0.67114547
67	INSRR	0.62819520
68	JAK3	0.62604145
69	TBK1	0.60493964
70	KDR	0.59876621
71	ALK	0.58193575
72	TESK2	0.58094464
73	DYRK2	0.58032938
74	PHKG2	0.54604416
75	PHKG1	0.54604416
76	PLK1	0.52586762
77	CSF1R	0.52248030
78	NEK2	0.49644676
79	RPS6KA5	0.49186501
80	PLK2	0.47718410
81	AURKB	0.47542305
82	LCK	0.47050584
83	LYN	0.46260360
84	IGF1R	0.45853776
85	ITK	0.44229201
86	PBK	0.44040857
87	CSNK2A1	0.43829287
88	PIM1	0.43623584
89	ADRBK1	0.41327361
90	CHUK	0.38194301
91	MAPK13	0.35914272
92	PRKCQ	0.34686356
93	SYK	0.34459106
94	CSNK2A2	0.33772965
95	STK38L	0.32308601
96	MUSK	0.31444249
97	CHEK2	0.31444145
98	TNIK	0.31226524
99	JAK1	0.31005525
100	FER	0.30326565

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.96758019
2	Protein export_Homo sapiens_hsa03060	2.96197503
3	RNA polymerase_Homo sapiens_hsa03020	2.72367410
4	Ribosome_Homo sapiens_hsa03010	2.70982710
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.67598517
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.27429966
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.17292922
8	Parkinsons disease_Homo sapiens_hsa05012	2.12691414
9	RNA degradation_Homo sapiens_hsa03018	2.10820341
10	Homologous recombination_Homo sapiens_hsa03440	2.08336669
11	Basal transcription factors_Homo sapiens_hsa03022	2.00040431
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.96036195
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87636450
14	Asthma_Homo sapiens_hsa05310	1.86475620
15	One carbon pool by folate_Homo sapiens_hsa00670	1.84743252
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.84548447
17	Mismatch repair_Homo sapiens_hsa03430	1.83676476
18	Allograft rejection_Homo sapiens_hsa05330	1.73857046
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.72289726
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.71088844
21	Spliceosome_Homo sapiens_hsa03040	1.68809379
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68123845
23	Propanoate metabolism_Homo sapiens_hsa00640	1.66400476
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.60994573
25	RNA transport_Homo sapiens_hsa03013	1.60914819
26	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.57844073
27	Base excision repair_Homo sapiens_hsa03410	1.54425011
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.53778463
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.53615505
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53116654
31	DNA replication_Homo sapiens_hsa03030	1.51606898
32	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.50929066
33	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50794483
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.38375786
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36369351
36	Phototransduction_Homo sapiens_hsa04744	1.34950989
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.33728312
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.32439926
39	Sulfur metabolism_Homo sapiens_hsa00920	1.26498554
40	Huntingtons disease_Homo sapiens_hsa05016	1.26372105
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.25119985
42	Selenocompound metabolism_Homo sapiens_hsa00450	1.20197374
43	Purine metabolism_Homo sapiens_hsa00230	1.19235205
44	Alzheimers disease_Homo sapiens_hsa05010	1.19127461
45	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18078817
46	Caffeine metabolism_Homo sapiens_hsa00232	1.13615850
47	Antigen processing and presentation_Homo sapiens_hsa04612	1.11499415
48	Nitrogen metabolism_Homo sapiens_hsa00910	1.05837875
49	Linoleic acid metabolism_Homo sapiens_hsa00591	1.03840990
50	Peroxisome_Homo sapiens_hsa04146	1.02643971
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.02321439
52	Tryptophan metabolism_Homo sapiens_hsa00380	1.01304956
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.97041246
54	Butanoate metabolism_Homo sapiens_hsa00650	0.93444342
55	Regulation of autophagy_Homo sapiens_hsa04140	0.91221006
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90705534
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.90364843
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82887902
59	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.81843437
60	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81027367
61	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77756311
62	Fatty acid elongation_Homo sapiens_hsa00062	0.73364449
63	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.66128384
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64464615
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64027891
66	Metabolic pathways_Homo sapiens_hsa01100	0.63928561
67	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61810075
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.61775878
69	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59683237
70	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59559224
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.57084356
72	Herpes simplex infection_Homo sapiens_hsa05168	0.56733670
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.55463041
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53846601
75	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.53127370
76	Glutathione metabolism_Homo sapiens_hsa00480	0.52160691
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.52151124
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51541667
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50923131
80	Retinol metabolism_Homo sapiens_hsa00830	0.50868442
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.49599652
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47142586
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45944272
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.45514087
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41820999
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38603857
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.37920078
88	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.35724689
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.35598004
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35411753
91	Carbon metabolism_Homo sapiens_hsa01200	0.34741813
92	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.34340001
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34000612
94	Viral myocarditis_Homo sapiens_hsa05416	0.32949008
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.32833006
96	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.32092805
97	Legionellosis_Homo sapiens_hsa05134	0.31409165
98	p53 signaling pathway_Homo sapiens_hsa04115	0.31293741
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.29850240
100	Olfactory transduction_Homo sapiens_hsa04740	0.27313288

EEF1GP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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