ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.12634471
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.96488226
3	cytidine metabolic process (GO:0046087)	5.80943657
4	cytidine catabolic process (GO:0006216)	5.80943657
5	cytidine deamination (GO:0009972)	5.80943657
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.92619025
7	Arp2/3 complex-mediated actin nucleation (GO:0034314)	4.91527327
8	actin nucleation (GO:0045010)	4.54434453
9	ncRNA 3-end processing (GO:0043628)	4.37582864
10	positive thymic T cell selection (GO:0045059)	4.30232705
11	ribosomal small subunit assembly (GO:0000028)	4.09172653
12	positive T cell selection (GO:0043368)	3.77471711
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.76898192
14	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.76165451
15	ribosomal small subunit biogenesis (GO:0042274)	3.65833479
16	regulation of gamma-delta T cell differentiation (GO:0045586)	3.58535957
17	regulation of regulatory T cell differentiation (GO:0045589)	3.54875047
18	positive regulation of gamma-delta T cell activation (GO:0046645)	3.40812844
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.39785375
20	ATP synthesis coupled proton transport (GO:0015986)	3.39785375
21	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.33897036
22	NADH metabolic process (GO:0006734)	3.32313407
23	response to interferon-beta (GO:0035456)	3.28083430
24	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.24133121
25	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	3.23920566
26	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.23287636
27	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.23124688
28	positive regulation of T cell mediated cytotoxicity (GO:0001916)	3.14479128
29	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.13631080
30	regulation of leukocyte mediated cytotoxicity (GO:0001910)	3.11302399
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.05534934
32	immunoglobulin mediated immune response (GO:0016064)	3.02574066
33	regulation of T cell mediated cytotoxicity (GO:0001914)	3.00020401
34	respiratory electron transport chain (GO:0022904)	2.99309340
35	regulation of natural killer cell mediated immunity (GO:0002715)	2.98879938
36	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.98879938
37	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.97557307
38	T cell migration (GO:0072678)	2.97104732
39	electron transport chain (GO:0022900)	2.97071770
40	negative T cell selection (GO:0043383)	2.96311676
41	mast cell activation involved in immune response (GO:0002279)	2.92973849
42	mast cell degranulation (GO:0043303)	2.92973849
43	regulation of gamma-delta T cell activation (GO:0046643)	2.92867589
44	fucose catabolic process (GO:0019317)	2.91955389
45	L-fucose metabolic process (GO:0042354)	2.91955389
46	L-fucose catabolic process (GO:0042355)	2.91955389
47	T cell receptor signaling pathway (GO:0050852)	2.91710138
48	T cell costimulation (GO:0031295)	2.91218414
49	regulation of cellular amino acid metabolic process (GO:0006521)	2.89199109
50	lymphocyte costimulation (GO:0031294)	2.88057765
51	negative regulation of T cell apoptotic process (GO:0070233)	2.87739386
52	tryptophan metabolic process (GO:0006568)	2.87653868
53	behavioral response to nicotine (GO:0035095)	2.87631124
54	negative regulation of phagocytosis (GO:0050765)	2.87031201
55	tryptophan catabolic process (GO:0006569)	2.86840166
56	indole-containing compound catabolic process (GO:0042436)	2.86840166
57	indolalkylamine catabolic process (GO:0046218)	2.86840166
58	thymic T cell selection (GO:0045061)	2.86826695
59	piRNA metabolic process (GO:0034587)	2.85408924
60	positive regulation of cell killing (GO:0031343)	2.84101235
61	sulfation (GO:0051923)	2.82382360
62	negative regulation of viral genome replication (GO:0045071)	2.80240522
63	regulation of cell killing (GO:0031341)	2.78074917
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.78023307
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.78023307
66	response to pheromone (GO:0019236)	2.76793648
67	positive regulation of defense response to virus by host (GO:0002230)	2.75541872
68	positive regulation of B cell differentiation (GO:0045579)	2.72946490
69	cellular response to interleukin-15 (GO:0071350)	2.72304679
70	mast cell activation (GO:0045576)	2.68631431
71	protein neddylation (GO:0045116)	2.66866989
72	positive regulation of interleukin-8 secretion (GO:2000484)	2.65989328
73	adaptation of signaling pathway (GO:0023058)	2.65865598
74	positive regulation of calcium-mediated signaling (GO:0050850)	2.65713169
75	protein import into peroxisome matrix (GO:0016558)	2.64603358
76	regulation of activation of Janus kinase activity (GO:0010533)	2.64315936
77	pyrimidine nucleoside catabolic process (GO:0046135)	2.64297467
78	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.61855914
79	sequestering of actin monomers (GO:0042989)	2.59497039
80	indolalkylamine metabolic process (GO:0006586)	2.59491419
81	detection of light stimulus involved in visual perception (GO:0050908)	2.58948628
82	detection of light stimulus involved in sensory perception (GO:0050962)	2.58948628
83	organelle membrane fusion (GO:0090174)	2.58285068
84	negative thymic T cell selection (GO:0045060)	2.58051270
85	regulation of alpha-beta T cell proliferation (GO:0046640)	2.57149399
86	antigen receptor-mediated signaling pathway (GO:0050851)	2.56915669
87	cellular response to interferon-beta (GO:0035458)	2.54642089
88	regulation of interleukin-8 secretion (GO:2000482)	2.54338014
89	rRNA modification (GO:0000154)	2.53906697
90	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.53152485
91	antigen processing and presentation of endogenous antigen (GO:0019883)	2.52107339
92	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.52010034
93	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.51756112
94	adenosine metabolic process (GO:0046085)	2.48813211
95	positive regulation of chemokine secretion (GO:0090197)	2.47175307
96	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.46191090
97	cytolysis (GO:0019835)	2.46009881
98	purine-containing compound salvage (GO:0043101)	2.41089382
99	autophagic vacuole fusion (GO:0000046)	2.40955168
100	regulation of B cell receptor signaling pathway (GO:0050855)	2.40727654

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.95035001
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.76918634
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.67623149
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.20472015
5	VDR_22108803_ChIP-Seq_LS180_Human	3.02075189
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.82724882
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.82469842
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.76297264
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.68425877
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.66500638
11	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.53149728
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.39077052
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.23580472
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16993807
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.04554988
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02369935
17	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.99390147
18	MYB_26560356_Chip-Seq_TH2_Human	1.97739168
19	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.76916163
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.75551366
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72214602
22	RUNX_20019798_ChIP-Seq_JUKART_Human	1.65037938
23	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.58901073
24	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.58058038
25	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.56239350
26	GATA3_26560356_Chip-Seq_TH2_Human	1.55488344
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.54600465
28	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.54325479
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.54325479
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52084059
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.51105248
32	EZH2_22144423_ChIP-Seq_EOC_Human	1.45920914
33	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.45459057
34	AR_20517297_ChIP-Seq_VCAP_Human	1.44792816
35	BCL6_27268052_Chip-Seq_Bcells_Human	1.44761909
36	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.44757295
37	NCOR_22424771_ChIP-Seq_293T_Human	1.42784248
38	GATA3_27048872_Chip-Seq_THYMUS_Human	1.42485746
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.41318748
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.40907517
41	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.40725399
42	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.40666275
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36506206
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34721042
45	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.34075820
46	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.32647694
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30415008
48	ERA_21632823_ChIP-Seq_H3396_Human	1.28941928
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.28177435
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.27654747
51	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27245025
52	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.27236627
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26229655
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.25559016
55	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.23388460
56	MYC_19829295_ChIP-Seq_ESCs_Human	1.21040496
57	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20852715
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.18823716
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18823716
60	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.18038072
61	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.15682838
62	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14723664
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.14189947
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13722874
65	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.12951617
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12676243
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12676243
68	FUS_26573619_Chip-Seq_HEK293_Human	1.10264986
69	P300_27268052_Chip-Seq_Bcells_Human	1.09745480
70	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09456429
71	EWS_26573619_Chip-Seq_HEK293_Human	1.08184167
72	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.06257809
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.06206106
74	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.05523879
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05073901
76	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.04423015
77	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04402156
78	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.03850723
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.02289591
80	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01607813
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01174226
82	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.00765896
83	MYB_26560356_Chip-Seq_TH1_Human	1.00409240
84	ER_23166858_ChIP-Seq_MCF-7_Human	0.99216186
85	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99059449
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.98656975
87	SPI1_23547873_ChIP-Seq_NB4_Human	0.97890014
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97784670
89	RAC3_21632823_ChIP-Seq_H3396_Human	0.97702576
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97601118
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97459783
92	STAT1_20625510_ChIP-Seq_HELA_Human	0.96157681
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.96000681
94	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95622566
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.95476685
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94936423
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.93597228
98	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93429716
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.92119551
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92087046

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.86610362
2	MP0001873_stomach_inflammation	2.90287437
3	MP0009785_altered_susceptibility_to	2.89174126
4	MP0006082_CNS_inflammation	2.72378349
5	MP0001835_abnormal_antigen_presentation	2.70673942
6	MP0005645_abnormal_hypothalamus_physiol	2.32916398
7	MP0003763_abnormal_thymus_physiology	2.25744143
8	MP0001800_abnormal_humoral_immune	2.24143759
9	MP0008875_abnormal_xenobiotic_pharmacok	2.16503905
10	MP0004510_myositis	2.08372041
11	MP0005410_abnormal_fertilization	2.03930063
12	MP0003646_muscle_fatigue	2.02516808
13	MP0005000_abnormal_immune_tolerance	1.99698262
14	MP0002166_altered_tumor_susceptibility	1.92147626
15	MP0002138_abnormal_hepatobiliary_system	1.89316214
16	MP0002420_abnormal_adaptive_immunity	1.88975346
17	MP0002723_abnormal_immune_serum	1.87015550
18	MP0001819_abnormal_immune_cell	1.84789814
19	MP0002148_abnormal_hypersensitivity_rea	1.83940443
20	MP0005025_abnormal_response_to	1.80541522
21	MP0003195_calcinosis	1.80379123
22	MP0010155_abnormal_intestine_physiology	1.79305299
23	MP0008872_abnormal_physiological_respon	1.78165513
24	MP0005075_abnormal_melanosome_morpholog	1.75933047
25	MP0009379_abnormal_foot_pigmentation	1.75584702
26	MP0009333_abnormal_splenocyte_physiolog	1.75047425
27	MP0002933_joint_inflammation	1.74204549
28	MP0002452_abnormal_antigen_presenting	1.73860189
29	MP0008877_abnormal_DNA_methylation	1.72614050
30	MP0003879_abnormal_hair_cell	1.66150385
31	MP0005377_hearing/vestibular/ear_phenot	1.61210375
32	MP0003878_abnormal_ear_physiology	1.61210375
33	MP0005646_abnormal_pituitary_gland	1.58649847
34	MP0005551_abnormal_eye_electrophysiolog	1.55134643
35	MP0000372_irregular_coat_pigmentation	1.53588562
36	MP0002006_tumorigenesis	1.47536008
37	MP0005360_urolithiasis	1.45998931
38	MP0003866_abnormal_defecation	1.45857611
39	MP0001845_abnormal_inflammatory_respons	1.44282964
40	MP0000716_abnormal_immune_system	1.44259437
41	MP0001905_abnormal_dopamine_level	1.43339781
42	MP0002419_abnormal_innate_immunity	1.40157925
43	MP0001986_abnormal_taste_sensitivity	1.39598221
44	MP0003724_increased_susceptibility_to	1.38962859
45	MP0006072_abnormal_retinal_apoptosis	1.38918771
46	MP0001968_abnormal_touch/_nociception	1.37774830
47	MP0005389_reproductive_system_phenotype	1.37134673
48	MP0001790_abnormal_immune_system	1.36322039
49	MP0005387_immune_system_phenotype	1.36322039
50	MP0009764_decreased_sensitivity_to	1.35076334
51	MP0002405_respiratory_system_inflammati	1.33284589
52	MP0002398_abnormal_bone_marrow	1.32289501
53	MP0004145_abnormal_muscle_electrophysio	1.31549325
54	MP0000689_abnormal_spleen_morphology	1.28548091
55	MP0001919_abnormal_reproductive_system	1.28331519
56	MP0003011_delayed_dark_adaptation	1.25185902
57	MP0008995_early_reproductive_senescence	1.21623614
58	MP0000685_abnormal_immune_system	1.19182795
59	MP0002722_abnormal_immune_system	1.17856870
60	MP0004147_increased_porphyrin_level	1.17838275
61	MP0002102_abnormal_ear_morphology	1.17815849
62	MP0002837_dystrophic_cardiac_calcinosis	1.17527998
63	MP0000703_abnormal_thymus_morphology	1.14447147
64	MP0001765_abnormal_ion_homeostasis	1.13115708
65	MP0002876_abnormal_thyroid_physiology	1.10157564
66	MP0002429_abnormal_blood_cell	1.09350011
67	MP0008469_abnormal_protein_level	1.06020716
68	MP0004947_skin_inflammation	1.04961057
69	MP0003436_decreased_susceptibility_to	1.01939455
70	MP0004885_abnormal_endolymph	0.99617160
71	MP0002160_abnormal_reproductive_system	0.98371021
72	MP0005084_abnormal_gallbladder_morpholo	0.98126192
73	MP0001663_abnormal_digestive_system	0.97824457
74	MP0005636_abnormal_mineral_homeostasis	0.96316160
75	MP0002736_abnormal_nociception_after	0.95201022
76	MP0003252_abnormal_bile_duct	0.93852164
77	MP0001984_abnormal_olfaction	0.93235088
78	MP0005253_abnormal_eye_physiology	0.91621539
79	MP0005174_abnormal_tail_pigmentation	0.87731766
80	MP0003806_abnormal_nucleotide_metabolis	0.86272671
81	MP0001533_abnormal_skeleton_physiology	0.85908100
82	MP0001485_abnormal_pinna_reflex	0.84887875
83	MP0000013_abnormal_adipose_tissue	0.84525725
84	MP0002638_abnormal_pupillary_reflex	0.83631326
85	MP0001727_abnormal_embryo_implantation	0.82899573
86	MP0005085_abnormal_gallbladder_physiolo	0.81898038
87	MP0009643_abnormal_urine_homeostasis	0.81414158
88	MP0006276_abnormal_autonomic_nervous	0.79532048
89	MP0002277_abnormal_respiratory_mucosa	0.77877162
90	MP0009763_increased_sensitivity_to	0.75880118
91	MP0002693_abnormal_pancreas_physiology	0.74466200
92	MP0000230_abnormal_systemic_arterial	0.73490936
93	MP0001929_abnormal_gametogenesis	0.72292939
94	MP0002272_abnormal_nervous_system	0.71695009
95	MP0002095_abnormal_skin_pigmentation	0.71664318
96	MP0003786_premature_aging	0.70669534
97	MP0003183_abnormal_peptide_metabolism	0.70079544
98	MP0005167_abnormal_blood-brain_barrier	0.69741725
99	MP0005166_decreased_susceptibility_to	0.69397015
100	MP0003718_maternal_effect	0.69343500

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Attenuation of retinal blood vessels (HP:0007843)	4.70463482
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.57506527
3	Constricted visual fields (HP:0001133)	4.03859360
4	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.98743347
5	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.91232796
6	IgG deficiency (HP:0004315)	3.85318687
7	T lymphocytopenia (HP:0005403)	3.70532444
8	Decreased central vision (HP:0007663)	3.57450055
9	Severe combined immunodeficiency (HP:0004430)	3.52756705
10	Abnormality of T cell number (HP:0011839)	3.41839725
11	Abnormality of macular pigmentation (HP:0008002)	3.39452912
12	Striae distensae (HP:0001065)	3.24293905
13	Cone-rod dystrophy (HP:0000548)	3.18595764
14	Abnormality of B cell number (HP:0010975)	3.18089059
15	Thyroiditis (HP:0100646)	3.03266533
16	Abnormal rod and cone electroretinograms (HP:0008323)	3.01420977
17	Mitochondrial inheritance (HP:0001427)	2.97147555
18	Abolished electroretinogram (ERG) (HP:0000550)	2.93910964
19	B lymphocytopenia (HP:0010976)	2.85148108
20	Hepatocellular necrosis (HP:0001404)	2.82197757
21	Acute necrotizing encephalopathy (HP:0006965)	2.76939714
22	Abnormality of T cells (HP:0002843)	2.72163367
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.71004793
24	Optic disc pallor (HP:0000543)	2.70542048
25	Combined immunodeficiency (HP:0005387)	2.68621343
26	Congenital stationary night blindness (HP:0007642)	2.67883116
27	Abnormality of the prostate (HP:0008775)	2.66019739
28	Pendular nystagmus (HP:0012043)	2.65689315
29	Autoimmune hemolytic anemia (HP:0001890)	2.65631280
30	Hepatic necrosis (HP:0002605)	2.62490294
31	Round ear (HP:0100830)	2.62112001
32	Chronic diarrhea (HP:0002028)	2.61093760
33	IgM deficiency (HP:0002850)	2.59627435
34	Hypoproteinemia (HP:0003075)	2.58064942
35	Aplastic anemia (HP:0001915)	2.57390542
36	Increased CSF lactate (HP:0002490)	2.51874070
37	Progressive macrocephaly (HP:0004481)	2.44750453
38	Absent/shortened dynein arms (HP:0200106)	2.44245544
39	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.44245544
40	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.39812842
41	Increased intramyocellular lipid droplets (HP:0012240)	2.39141348
42	Abnormal albumin level (HP:0012116)	2.35189970
43	Hypoalbuminemia (HP:0003073)	2.35189970
44	Type 2 muscle fiber atrophy (HP:0003554)	2.33541341
45	Acute encephalopathy (HP:0006846)	2.33124040
46	Asplenia (HP:0001746)	2.31986470
47	Abnormality of eosinophils (HP:0001879)	2.30738401
48	Increased hepatocellular lipid droplets (HP:0006565)	2.30154022
49	Keratoconus (HP:0000563)	2.29708162
50	Increased corneal curvature (HP:0100692)	2.29708162
51	Renal Fanconi syndrome (HP:0001994)	2.27332435
52	Cerebral edema (HP:0002181)	2.21602584
53	Recurrent bronchitis (HP:0002837)	2.20194795
54	Pancreatic fibrosis (HP:0100732)	2.16922573
55	Toxemia of pregnancy (HP:0100603)	2.15799324
56	Encephalitis (HP:0002383)	2.13711013
57	Panhypogammaglobulinemia (HP:0003139)	2.12743006
58	Hypoplasia of the uterus (HP:0000013)	2.11795612
59	Myositis (HP:0100614)	2.09915822
60	Lipid accumulation in hepatocytes (HP:0006561)	2.08458196
61	Abnormality of fatty-acid metabolism (HP:0004359)	2.06100116
62	Cupped ribs (HP:0000887)	2.05508686
63	Stomatitis (HP:0010280)	2.03750054
64	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.03586159
65	Pancreatic cysts (HP:0001737)	2.01321543
66	Volvulus (HP:0002580)	1.99495602
67	Muscle fiber atrophy (HP:0100295)	1.98261610
68	Congenital, generalized hypertrichosis (HP:0004540)	1.97698864
69	Abnormal drinking behavior (HP:0030082)	1.97429162
70	Polydipsia (HP:0001959)	1.97429162
71	Recurrent sinusitis (HP:0011108)	1.97362359
72	Increased muscle lipid content (HP:0009058)	1.96996262
73	Abnormality of T cell physiology (HP:0011840)	1.95941752
74	Optic neuritis (HP:0100653)	1.95791481
75	Retrobulbar optic neuritis (HP:0100654)	1.95791481
76	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.93724637
77	Abnormality of urine glucose concentration (HP:0011016)	1.93381451
78	Glycosuria (HP:0003076)	1.93381451
79	Ketosis (HP:0001946)	1.93042127
80	Recurrent otitis media (HP:0000403)	1.89601252
81	Chronic mucocutaneous candidiasis (HP:0002728)	1.89510872
82	Recurrent cutaneous fungal infections (HP:0011370)	1.89510872
83	Vasculitis (HP:0002633)	1.89079432
84	Agammaglobulinemia (HP:0004432)	1.87184164
85	Cerebral palsy (HP:0100021)	1.86628476
86	Leukocytosis (HP:0001974)	1.86469349
87	Hypothermia (HP:0002045)	1.85468556
88	Alkalosis (HP:0001948)	1.84978732
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.84297688
90	Type I transferrin isoform profile (HP:0003642)	1.82382451
91	True hermaphroditism (HP:0010459)	1.81873672
92	Hyperglycinemia (HP:0002154)	1.81754353
93	Lethargy (HP:0001254)	1.80313896
94	Hemiplegia (HP:0002301)	1.80173083
95	Emotional lability (HP:0000712)	1.79484829
96	Lactic acidosis (HP:0003128)	1.78651112
97	Exertional dyspnea (HP:0002875)	1.78443892
98	Eosinophilia (HP:0001880)	1.78370078
99	Bronchitis (HP:0012387)	1.77097826
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.75983709

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	3.96362877
2	KIT	3.95939331
3	KDR	3.57928886
4	TXK	3.55886359
5	TLK1	3.52613240
6	BCKDK	3.34564272
7	TAOK3	2.85930434
8	ZAK	2.67969489
9	FES	2.55028768
10	FRK	2.53076189
11	TEC	2.48283372
12	MAP4K1	2.47188168
13	MAP4K2	2.30011556
14	SCYL2	2.12995261
15	TIE1	2.08891613
16	ADRBK2	2.05970134
17	SYK	1.78133492
18	ITK	1.73817522
19	GRK1	1.65100460
20	STK16	1.64946802
21	VRK2	1.61375004
22	GRK6	1.59268382
23	IKBKE	1.48942005
24	VRK1	1.41583886
25	INSRR	1.39359433
26	IKBKB	1.37257293
27	TESK1	1.35450019
28	PLK4	1.30961194
29	NUAK1	1.25972984
30	CSF1R	1.25117114
31	BTK	1.22237268
32	MST4	1.22151588
33	WNK4	1.20376460
34	EIF2AK3	1.17824938
35	CSK	1.16966006
36	BMPR1B	1.13379949
37	LIMK1	1.10330818
38	LCK	1.07775586
39	PRKCQ	1.07440449
40	TNK2	1.06993019
41	TBK1	0.99306928
42	LYN	0.92943419
43	ACVR1B	0.89629766
44	PLK2	0.83197610
45	PIK3CG	0.82602405
46	RPS6KA5	0.79534252
47	PHKG2	0.74207667
48	PHKG1	0.74207667
49	ZAP70	0.74006056
50	ADRBK1	0.73717302
51	STK39	0.72453803
52	PASK	0.69272611
53	WNK3	0.67621387
54	PINK1	0.63999970
55	TYRO3	0.60773312
56	NME2	0.57487263
57	JAK3	0.56280957
58	MAPKAPK5	0.56205595
59	OBSCN	0.53623918
60	OXSR1	0.53317401
61	GRK7	0.52710480
62	PRKCA	0.50081059
63	MYLK	0.46181233
64	DAPK1	0.45906409
65	CSNK1G3	0.44380663
66	INSR	0.44230735
67	PRKACA	0.42141220
68	PIM2	0.42091751
69	EGFR	0.41937653
70	IGF1R	0.40709191
71	FYN	0.39899945
72	CDK19	0.38356920
73	ERBB3	0.38235556
74	PRKCG	0.37346014
75	BMPR2	0.37261000
76	GRK5	0.36047538
77	PRKCI	0.35614264
78	RIPK4	0.34868225
79	ABL1	0.34593859
80	HCK	0.33845960
81	SRC	0.33384654
82	MAPK11	0.32913351
83	MUSK	0.32023907
84	ABL2	0.31849198
85	MATK	0.31777890
86	MAPKAPK3	0.31749710
87	ARAF	0.31417058
88	CSNK1G1	0.31046610
89	FLT3	0.30182234
90	PRKCB	0.28716215
91	PIM1	0.27515437
92	MAP2K6	0.27262732
93	FGFR2	0.26491925
94	MAPK13	0.26389793
95	MAP3K14	0.26008589
96	MAP3K12	0.25322030
97	MKNK1	0.25240992
98	CSNK1A1	0.24430881
99	PRKCD	0.23825380
100	CSNK2A1	0.23439741

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	4.25730229
2	Graft-versus-host disease_Homo sapiens_hsa05332	3.32702938
3	Proteasome_Homo sapiens_hsa03050	3.29986008
4	Allograft rejection_Homo sapiens_hsa05330	3.16806991
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.12675252
6	Oxidative phosphorylation_Homo sapiens_hsa00190	3.06087953
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.83871051
8	Antigen processing and presentation_Homo sapiens_hsa04612	2.67775440
9	Asthma_Homo sapiens_hsa05310	2.65080269
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.62913744
11	Ribosome_Homo sapiens_hsa03010	2.42462780
12	Parkinsons disease_Homo sapiens_hsa05012	2.33323396
13	Phototransduction_Homo sapiens_hsa04744	2.29727240
14	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.94854850
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.85166186
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78019639
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.74196541
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.66135855
19	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.56852528
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.49083496
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.46951147
22	Alzheimers disease_Homo sapiens_hsa05010	1.46448525
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45404152
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43560518
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.36829239
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34501454
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.34368593
28	Huntingtons disease_Homo sapiens_hsa05016	1.31699171
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.24246632
30	Viral myocarditis_Homo sapiens_hsa05416	1.23005495
31	Caffeine metabolism_Homo sapiens_hsa00232	1.19420142
32	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.17995703
33	RNA polymerase_Homo sapiens_hsa03020	1.17907962
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12875592
35	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.12198795
36	Peroxisome_Homo sapiens_hsa04146	1.10911331
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.07097973
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.01877180
39	Olfactory transduction_Homo sapiens_hsa04740	0.99659796
40	Fat digestion and absorption_Homo sapiens_hsa04975	0.96886543
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.95647804
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.94998813
43	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93330731
44	Sulfur metabolism_Homo sapiens_hsa00920	0.92715868
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91929297
46	Butanoate metabolism_Homo sapiens_hsa00650	0.90390861
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.86334020
48	Retinol metabolism_Homo sapiens_hsa00830	0.83088702
49	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.81526551
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81405656
51	RNA degradation_Homo sapiens_hsa03018	0.79707160
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78708235
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78489830
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78188486
55	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.77762466
56	Purine metabolism_Homo sapiens_hsa00230	0.74750208
57	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72620819
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70837609
59	Propanoate metabolism_Homo sapiens_hsa00640	0.68023475
60	Protein export_Homo sapiens_hsa03060	0.67663041
61	Malaria_Homo sapiens_hsa05144	0.64699328
62	Leishmaniasis_Homo sapiens_hsa05140	0.63831755
63	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63213051
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.62553430
65	Measles_Homo sapiens_hsa05162	0.61691995
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.60189911
67	Histidine metabolism_Homo sapiens_hsa00340	0.59216824
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.58772471
69	Fatty acid degradation_Homo sapiens_hsa00071	0.57502509
70	Homologous recombination_Homo sapiens_hsa03440	0.57273526
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56704645
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.54219020
73	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.52600946
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50783707
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48030895
76	ABC transporters_Homo sapiens_hsa02010	0.47978877
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.47403485
78	One carbon pool by folate_Homo sapiens_hsa00670	0.47212917
79	Metabolic pathways_Homo sapiens_hsa01100	0.46295021
80	Taste transduction_Homo sapiens_hsa04742	0.46061045
81	Shigellosis_Homo sapiens_hsa05131	0.44779383
82	Herpes simplex infection_Homo sapiens_hsa05168	0.44582492
83	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41152730
84	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40569737
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39388981
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39115056
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.37260548
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36659356
89	Nicotine addiction_Homo sapiens_hsa05033	0.35468247
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34692627
91	Base excision repair_Homo sapiens_hsa03410	0.32151276
92	Salivary secretion_Homo sapiens_hsa04970	0.30774380
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28101599
94	Renin-angiotensin system_Homo sapiens_hsa04614	0.24902802
95	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.23044810
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.21882124
97	Sulfur relay system_Homo sapiens_hsa04122	0.20607711
98	Pertussis_Homo sapiens_hsa05133	0.19615605
99	Basal transcription factors_Homo sapiens_hsa03022	0.19219405
100	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.18387143

EEF1GP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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