EEF1GP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.88757687
2L-fucose catabolic process (GO:0042355)4.18108990
3fucose catabolic process (GO:0019317)4.18108990
4L-fucose metabolic process (GO:0042354)4.18108990
5positive regulation of prostaglandin secretion (GO:0032308)4.15876333
6regulation of germinal center formation (GO:0002634)4.14564772
7regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.85325702
8cullin deneddylation (GO:0010388)3.82785710
9protein deneddylation (GO:0000338)3.71176412
10negative regulation of telomere maintenance (GO:0032205)3.62075716
11negative regulation of B cell apoptotic process (GO:0002903)3.52358839
12positive regulation of antigen processing and presentation (GO:0002579)3.50625442
13response to gravity (GO:0009629)3.47385676
14piRNA metabolic process (GO:0034587)3.44662484
15antigen processing and presentation of endogenous antigen (GO:0019883)3.40797685
16immunoglobulin mediated immune response (GO:0016064)3.35711737
17positive regulation of defense response to virus by host (GO:0002230)3.33705175
18sleep (GO:0030431)3.25192288
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.20320795
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.20320795
21regulation of memory T cell differentiation (GO:0043380)3.17325401
22regulation of prostaglandin secretion (GO:0032306)3.15674440
23positive regulation of fatty acid transport (GO:2000193)3.14600316
24negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.13967634
25negative regulation of T-helper cell differentiation (GO:0045623)3.13967634
26RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10436978
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.09920945
28regulation of B cell apoptotic process (GO:0002902)3.09494265
29endoderm formation (GO:0001706)3.05592725
30regulation of antigen processing and presentation (GO:0002577)3.01292778
31positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99641752
32protein-cofactor linkage (GO:0018065)2.98031769
33preassembly of GPI anchor in ER membrane (GO:0016254)2.97030061
34pseudouridine synthesis (GO:0001522)2.96315456
35negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.96030299
36positive regulation of icosanoid secretion (GO:0032305)2.95256116
37platelet dense granule organization (GO:0060155)2.94752344
38ATP synthesis coupled proton transport (GO:0015986)2.94296019
39energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94296019
40adenosine metabolic process (GO:0046085)2.93522898
41negative regulation of mast cell activation (GO:0033004)2.93150927
42cytidine metabolic process (GO:0046087)2.90043177
43cytidine catabolic process (GO:0006216)2.90043177
44cytidine deamination (GO:0009972)2.90043177
45positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.88188855
46regulation of immunoglobulin secretion (GO:0051023)2.87793866
47positive regulation of T-helper 1 type immune response (GO:0002827)2.86518464
48water-soluble vitamin biosynthetic process (GO:0042364)2.86513605
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86234599
50mitochondrial respiratory chain complex I assembly (GO:0032981)2.86234599
51NADH dehydrogenase complex assembly (GO:0010257)2.86234599
52regulation of T cell receptor signaling pathway (GO:0050856)2.83380332
53response to pheromone (GO:0019236)2.83166634
54regulation of defense response to virus by host (GO:0050691)2.81625288
55regulation of T cell mediated cytotoxicity (GO:0001914)2.79926601
56kynurenine metabolic process (GO:0070189)2.75299654
57positive regulation of protein homodimerization activity (GO:0090073)2.74351247
58T cell differentiation involved in immune response (GO:0002292)2.73388714
59alpha-beta T cell differentiation involved in immune response (GO:0002293)2.73388714
60alpha-beta T cell activation involved in immune response (GO:0002287)2.73388714
61protein complex biogenesis (GO:0070271)2.72125309
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71924161
63ubiquinone biosynthetic process (GO:0006744)2.68312511
64tolerance induction (GO:0002507)2.68077702
65regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.67874198
66detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65632704
67exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65020772
68positive regulation of osteoclast differentiation (GO:0045672)2.63644404
69B cell mediated immunity (GO:0019724)2.62834852
70RNA destabilization (GO:0050779)2.62733602
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.61810090
72indole-containing compound catabolic process (GO:0042436)2.61777165
73indolalkylamine catabolic process (GO:0046218)2.61777165
74tryptophan catabolic process (GO:0006569)2.61777165
75branched-chain amino acid catabolic process (GO:0009083)2.61254684
76behavioral response to nicotine (GO:0035095)2.59707260
77regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.59071338
78cellular response to exogenous dsRNA (GO:0071360)2.59025093
79tryptophan metabolic process (GO:0006568)2.58455097
80indolalkylamine metabolic process (GO:0006586)2.58035814
81phosphatidylinositol acyl-chain remodeling (GO:0036149)2.54638868
82T-helper cell differentiation (GO:0042093)2.53569354
83CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.53569354
84mitochondrial respiratory chain complex assembly (GO:0033108)2.53087828
85DNA methylation involved in gamete generation (GO:0043046)2.52965720
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51194971
87S-adenosylmethionine metabolic process (GO:0046500)2.51165869
88regulation of mitotic spindle checkpoint (GO:1903504)2.50724495
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50724495
90regulation of isotype switching to IgG isotypes (GO:0048302)2.49687919
91positive thymic T cell selection (GO:0045059)2.48174590
92response to interferon-beta (GO:0035456)2.46843414
93chaperone-mediated protein transport (GO:0072321)2.46461947
94pyrimidine ribonucleoside catabolic process (GO:0046133)2.46343374
95antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45896433
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.45567784
97negative regulation of thymocyte apoptotic process (GO:0070244)2.44413665
98iron-sulfur cluster assembly (GO:0016226)2.44030518
99metallo-sulfur cluster assembly (GO:0031163)2.44030518
100negative regulation of T cell differentiation (GO:0045581)2.43995916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.74140191
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.40664511
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11525521
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94318272
5ZNF274_21170338_ChIP-Seq_K562_Hela2.84408413
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62821430
7VDR_22108803_ChIP-Seq_LS180_Human2.61201477
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.51928435
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.46748587
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44361728
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44121559
12VDR_23849224_ChIP-Seq_CD4+_Human2.39348037
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38653609
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37786878
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.32205480
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.24768444
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16695931
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.08415930
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04985538
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.93312684
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91700835
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91222219
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.87196827
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86119224
25GATA3_26560356_Chip-Seq_TH2_Human1.84290044
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83564171
27ELK1_19687146_ChIP-ChIP_HELA_Human1.73758188
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71707535
29FUS_26573619_Chip-Seq_HEK293_Human1.71262498
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70567403
31FOXP3_21729870_ChIP-Seq_TREG_Human1.70268294
32IRF1_19129219_ChIP-ChIP_H3396_Human1.65518809
33MYC_18940864_ChIP-ChIP_HL60_Human1.65487172
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62557957
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60050742
36AR_20517297_ChIP-Seq_VCAP_Human1.59798117
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55254008
38TP53_22573176_ChIP-Seq_HFKS_Human1.54563548
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54428777
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52938862
41IGF1R_20145208_ChIP-Seq_DFB_Human1.52315235
42EWS_26573619_Chip-Seq_HEK293_Human1.47218921
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41626865
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37164118
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36917827
46CIITA_25753668_ChIP-Seq_RAJI_Human1.36666771
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35719747
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34453085
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.34453085
50NANOG_20526341_ChIP-Seq_ESCs_Human1.29829746
51TAF2_19829295_ChIP-Seq_ESCs_Human1.29822083
52MYB_26560356_Chip-Seq_TH2_Human1.29181770
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.28979623
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27497061
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.25980200
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24068749
57GATA3_27048872_Chip-Seq_THYMUS_Human1.23780087
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22022451
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21893172
60MYC_19829295_ChIP-Seq_ESCs_Human1.20649156
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.18976787
62SOX2_19829295_ChIP-Seq_ESCs_Human1.18885281
63NANOG_19829295_ChIP-Seq_ESCs_Human1.18885281
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18723107
65CBP_20019798_ChIP-Seq_JUKART_Human1.18723107
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18270936
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15103390
68NCOR_22424771_ChIP-Seq_293T_Human1.14156937
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13783232
70TAF15_26573619_Chip-Seq_HEK293_Human1.13524971
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.13283488
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12186122
73ERA_21632823_ChIP-Seq_H3396_Human1.11670541
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11644049
75RUNX_20019798_ChIP-Seq_JUKART_Human1.11224039
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09960168
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09789989
78ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09103549
79STAT1_20625510_ChIP-Seq_HELA_Human1.07980875
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07897131
81FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07641097
82ER_23166858_ChIP-Seq_MCF-7_Human1.07491140
83GATA3_26560356_Chip-Seq_TH1_Human1.07006758
84P300_19829295_ChIP-Seq_ESCs_Human1.06282355
85BCL6_27268052_Chip-Seq_Bcells_Human1.05388510
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05218325
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03861396
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03688096
89FOXH1_21741376_ChIP-Seq_EPCs_Human1.03195925
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.03019200
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00744972
92AR_21572438_ChIP-Seq_LNCaP_Human0.98898398
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98249101
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97005927
95E2F1_20622854_ChIP-Seq_HELA_Human0.96383058
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95403938
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.94562497
98PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93163255
99CEBPB_22108803_ChIP-Seq_LS180_Human0.93151290
100P53_21459846_ChIP-Seq_SAOS-2_Human0.93110483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.22396063
2MP0001835_abnormal_antigen_presentation3.45306055
3MP0003724_increased_susceptibility_to3.11732958
4MP0005075_abnormal_melanosome_morpholog3.02501175
5MP0008875_abnormal_xenobiotic_pharmacok2.92307065
6MP0005671_abnormal_response_to2.86023581
7MP0000685_abnormal_immune_system2.46790972
8MP0002148_abnormal_hypersensitivity_rea2.39856437
9MP0004147_increased_porphyrin_level2.30311438
10MP0006072_abnormal_retinal_apoptosis2.28607135
11MP0002102_abnormal_ear_morphology2.24254450
12MP0005000_abnormal_immune_tolerance2.15170245
13MP0005646_abnormal_pituitary_gland2.09049540
14MP0005645_abnormal_hypothalamus_physiol2.08815819
15MP0003195_calcinosis2.08128408
16MP0001800_abnormal_humoral_immune2.06725769
17MP0008872_abnormal_physiological_respon2.04477472
18MP0009785_altered_susceptibility_to1.93505240
19MP0002166_altered_tumor_susceptibility1.80552040
20MP0001968_abnormal_touch/_nociception1.78165902
21MP0002723_abnormal_immune_serum1.74916317
22MP0003646_muscle_fatigue1.74202261
23MP0001986_abnormal_taste_sensitivity1.74017671
24MP0008877_abnormal_DNA_methylation1.72628958
25MP0000372_irregular_coat_pigmentation1.71304463
26MP0004145_abnormal_muscle_electrophysio1.67994720
27MP0002452_abnormal_antigen_presenting1.66057965
28MP0001790_abnormal_immune_system1.60649560
29MP0005387_immune_system_phenotype1.60649560
30MP0005167_abnormal_blood-brain_barrier1.59628332
31MP0002006_tumorigenesis1.59045895
32MP0003436_decreased_susceptibility_to1.56970427
33MP0002420_abnormal_adaptive_immunity1.50509867
34MP0001819_abnormal_immune_cell1.50338283
35MP0005551_abnormal_eye_electrophysiolog1.46756373
36MP0002837_dystrophic_cardiac_calcinosis1.46284269
37MP0001873_stomach_inflammation1.44268578
38MP0001501_abnormal_sleep_pattern1.43774009
39MP0005084_abnormal_gallbladder_morpholo1.41738158
40MP0006036_abnormal_mitochondrial_physio1.41006311
41MP0009764_decreased_sensitivity_to1.35456576
42MP0001905_abnormal_dopamine_level1.34546669
43MP0004885_abnormal_endolymph1.33237886
44MP0002736_abnormal_nociception_after1.28469727
45MP0003011_delayed_dark_adaptation1.26202584
46MP0008775_abnormal_heart_ventricle1.24993528
47MP0000689_abnormal_spleen_morphology1.22052809
48MP0005253_abnormal_eye_physiology1.18108641
49MP0006292_abnormal_olfactory_placode1.17858293
50MP0008058_abnormal_DNA_repair1.16603791
51MP0002405_respiratory_system_inflammati1.14237373
52MP0000716_abnormal_immune_system1.12477116
53MP0004043_abnormal_pH_regulation1.11515827
54MP0002638_abnormal_pupillary_reflex1.11412869
55MP0003763_abnormal_thymus_physiology1.10093423
56MP0005025_abnormal_response_to1.07388453
57MP0003252_abnormal_bile_duct1.06426372
58MP0002398_abnormal_bone_marrow1.06054638
59MP0005085_abnormal_gallbladder_physiolo1.05351772
60MP0002933_joint_inflammation1.05011942
61MP0001853_heart_inflammation1.02934534
62MP0004782_abnormal_surfactant_physiolog1.00100182
63MP0001533_abnormal_skeleton_physiology0.99948437
64MP0006054_spinal_hemorrhage0.99945861
65MP0002419_abnormal_innate_immunity0.99794751
66MP0002722_abnormal_immune_system0.97831575
67MP0002272_abnormal_nervous_system0.97093962
68MP0010155_abnormal_intestine_physiology0.96049756
69MP0009046_muscle_twitch0.95886282
70MP0003718_maternal_effect0.95394728
71MP0002876_abnormal_thyroid_physiology0.94082755
72MP0003866_abnormal_defecation0.92566046
73MP0006035_abnormal_mitochondrial_morpho0.90429613
74MP0001845_abnormal_inflammatory_respons0.88940814
75MP0006276_abnormal_autonomic_nervous0.87985423
76MP0002429_abnormal_blood_cell0.83671758
77MP0002095_abnormal_skin_pigmentation0.83424771
78MP0000230_abnormal_systemic_arterial0.81389811
79MP0009643_abnormal_urine_homeostasis0.80863866
80MP0008469_abnormal_protein_level0.80327546
81MP0005410_abnormal_fertilization0.80289858
82MP0003786_premature_aging0.76959490
83MP0002234_abnormal_pharynx_morphology0.73713928
84MP0009333_abnormal_splenocyte_physiolog0.72456365
85MP0005636_abnormal_mineral_homeostasis0.71581089
86MP0003186_abnormal_redox_activity0.71431888
87MP0009745_abnormal_behavioral_response0.71103798
88MP0005174_abnormal_tail_pigmentation0.70370324
89MP0003806_abnormal_nucleotide_metabolis0.70031164
90MP0004484_altered_response_of0.69622661
91MP0002733_abnormal_thermal_nociception0.69121933
92MP0000703_abnormal_thymus_morphology0.68065281
93MP0008995_early_reproductive_senescence0.68064608
94MP0004142_abnormal_muscle_tone0.67598067
95MP0004381_abnormal_hair_follicle0.67411808
96MP0001765_abnormal_ion_homeostasis0.66623244
97MP0001764_abnormal_homeostasis0.65090864
98MP0000465_gastrointestinal_hemorrhage0.64880794
99MP0005389_reproductive_system_phenotype0.63701210
100MP0001970_abnormal_pain_threshold0.62798380

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.51618248
2Congenital stationary night blindness (HP:0007642)3.63697952
3Pancreatic cysts (HP:0001737)3.58985897
4Abnormality of the prostate (HP:0008775)3.58603705
5IgG deficiency (HP:0004315)3.56781787
6Pancreatic fibrosis (HP:0100732)3.50871411
7Abolished electroretinogram (ERG) (HP:0000550)3.40620227
8Prostate neoplasm (HP:0100787)3.34580387
9Type 2 muscle fiber atrophy (HP:0003554)3.16777402
10Abnormality of midbrain morphology (HP:0002418)3.09409225
11Molar tooth sign on MRI (HP:0002419)3.09409225
12Type II lissencephaly (HP:0007260)3.08198415
133-Methylglutaconic aciduria (HP:0003535)3.07378854
14Decreased central vision (HP:0007663)2.92151327
15Nephronophthisis (HP:0000090)2.89532648
16Attenuation of retinal blood vessels (HP:0007843)2.89428485
17Agammaglobulinemia (HP:0004432)2.89350303
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88515001
19Abnormality of alanine metabolism (HP:0010916)2.88515001
20Hyperalaninemia (HP:0003348)2.88515001
21Abnormality of the renal cortex (HP:0011035)2.86368659
22Renal cortical cysts (HP:0000803)2.85786474
23True hermaphroditism (HP:0010459)2.79671575
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.78341236
25Increased corneal curvature (HP:0100692)2.73847737
26Keratoconus (HP:0000563)2.73847737
27Mitochondrial inheritance (HP:0001427)2.64620563
28Muscle fiber atrophy (HP:0100295)2.61875464
29Hepatocellular necrosis (HP:0001404)2.60899276
30Lipid accumulation in hepatocytes (HP:0006561)2.59386589
31Abnormal number of erythroid precursors (HP:0012131)2.55983521
32Abnormal biliary tract physiology (HP:0012439)2.53642521
33Bile duct proliferation (HP:0001408)2.53642521
34Increased CSF lactate (HP:0002490)2.52679869
35Abnormal rod and cone electroretinograms (HP:0008323)2.52058421
36Abnormality of the renal medulla (HP:0100957)2.48238342
37Increased hepatocellular lipid droplets (HP:0006565)2.46220943
38Adactyly (HP:0009776)2.46189961
39Myositis (HP:0100614)2.45906245
40Cerebellar dysplasia (HP:0007033)2.42833699
41Pendular nystagmus (HP:0012043)2.42570331
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.41314566
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.39041390
44Stomatitis (HP:0010280)2.36422601
45Hepatic necrosis (HP:0002605)2.35635965
46Acute necrotizing encephalopathy (HP:0006965)2.33547876
47Abnormality of T cell physiology (HP:0011840)2.31499965
48Methylmalonic acidemia (HP:0002912)2.31286065
49Asplenia (HP:0001746)2.25831791
50Increased serum lactate (HP:0002151)2.23551525
51Aplasia/hypoplasia of the uterus (HP:0008684)2.22917358
52Cystic liver disease (HP:0006706)2.19995981
53Panhypogammaglobulinemia (HP:0003139)2.18071807
54Abnormality of cells of the erythroid lineage (HP:0012130)2.14664175
55Abnormality of B cell number (HP:0010975)2.14480183
56Abnormal mitochondria in muscle tissue (HP:0008316)2.14405990
57Congenital, generalized hypertrichosis (HP:0004540)2.14342271
58Progressive microcephaly (HP:0000253)2.11680291
59Delayed CNS myelination (HP:0002188)2.11536849
60Retrobulbar optic neuritis (HP:0100654)2.09931532
61Optic neuritis (HP:0100653)2.09931532
62Chronic sinusitis (HP:0011109)2.08652403
63Lactic acidosis (HP:0003128)2.06922201
64Testicular atrophy (HP:0000029)2.04288462
65Pulmonary infiltrates (HP:0002113)2.04109727
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.02366981
67Pulmonary fibrosis (HP:0002206)2.01233402
68Methylmalonic aciduria (HP:0012120)1.99791132
69Progressive macrocephaly (HP:0004481)1.99018864
70Abnormality of T cells (HP:0002843)1.93927585
71Polyuria (HP:0000103)1.93894654
72Abnormality of male internal genitalia (HP:0000022)1.91170241
73Acute encephalopathy (HP:0006846)1.90982348
74Hypoplasia of the uterus (HP:0000013)1.89509620
75Chronic otitis media (HP:0000389)1.88288625
76Hypomagnesemia (HP:0002917)1.87733383
77Abnormal drinking behavior (HP:0030082)1.87076222
78Polydipsia (HP:0001959)1.87076222
79Stomach cancer (HP:0012126)1.85905181
80Abnormal delayed hypersensitivity skin test (HP:0002963)1.85882102
81Hypoplasia of the pons (HP:0012110)1.83683441
82Abnormality of the pons (HP:0007361)1.82155164
83Severe combined immunodeficiency (HP:0004430)1.78638528
84Optic disc pallor (HP:0000543)1.76486941
85Increased intramyocellular lipid droplets (HP:0012240)1.76217725
86Pustule (HP:0200039)1.73723884
87Mediastinal lymphadenopathy (HP:0100721)1.73289712
88Abnormality of dicarboxylic acid metabolism (HP:0010995)1.70356741
89Dicarboxylic aciduria (HP:0003215)1.70356741
90Opisthotonus (HP:0002179)1.69869355
91Short tibia (HP:0005736)1.69585321
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68561823
93Cerebral palsy (HP:0100021)1.68431036
94Increased neuronal autofluorescent lipopigment (HP:0002074)1.67408455
95Tubulointerstitial nephritis (HP:0001970)1.66617333
96Sclerocornea (HP:0000647)1.66426931
97Orchitis (HP:0100796)1.66197745
98Cerebral edema (HP:0002181)1.65884704
99Abnormality of the proximal phalanges of the hand (HP:0009834)1.65725664
100Absent phalangeal crease (HP:0006109)1.64291446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.79604669
2ZAK3.20256793
3TXK3.02660390
4BCKDK3.02125771
5ADRBK22.87157191
6MAP3K142.85359432
7GRK12.77849723
8MAP4K22.75966518
9FRK2.63181972
10TAOK32.60727892
11KIT2.27029119
12TIE12.14415145
13MAP3K131.98248213
14WNK41.97030911
15NUAK11.84645438
16IKBKB1.84570810
17VRK21.83584169
18MAP2K21.83300664
19MAPKAPK31.79519167
20TESK21.77777528
21PHKG21.71485672
22PHKG11.71485672
23GRK61.69495104
24IKBKE1.55792404
25MST41.51261102
26FES1.49161005
27EIF2AK31.48221495
28SYK1.48039788
29TBK11.39186348
30CSNK1G31.31938391
31PINK11.24867189
32VRK11.19933137
33TEC1.15325169
34JAK31.15046121
35ITK1.14720506
36OXSR11.14239258
37SCYL21.02401192
38KDR1.02085207
39CSNK1G11.01026502
40CSNK1A1L0.97701004
41MAP4K10.96332620
42STK160.93997916
43EIF2AK20.90877125
44CHUK0.89707312
45CSNK1G20.89024900
46CAMKK20.88877135
47CDK80.88869297
48BMPR1B0.86480463
49DAPK10.85658539
50RPS6KA50.81690213
51ADRBK10.78007200
52CCNB10.77697519
53MAPK130.75867797
54MAPKAPK50.74435460
55MATK0.74388910
56LYN0.73311145
57STK390.71095200
58DAPK20.71085940
59NME10.69724199
60PRKCQ0.68681153
61LCK0.68665798
62FLT30.68657037
63PRKCI0.66910327
64BTK0.66270408
65CDK190.64707144
66MKNK10.63944059
67OBSCN0.63895472
68PLK20.63467081
69WNK30.61690084
70INSRR0.57101582
71ACVR1B0.56186616
72PBK0.53908749
73GRK70.52664598
74CSF1R0.52017575
75ERBB30.48295090
76SRPK10.47498992
77IGF1R0.45332986
78PRKCE0.44213039
79PLK30.41648827
80LIMK10.41307821
81FER0.40678518
82DYRK20.39272661
83BMPR20.37487155
84HCK0.37143405
85ABL10.35840916
86PKN10.35349661
87MAP2K10.34633704
88ATR0.34041746
89PIM10.33611283
90MAPK110.32460189
91SIK20.32098177
92RPS6KA60.31191240
93MAP3K40.30693037
94PRKCA0.28833086
95MAPK70.27031839
96CSNK1A10.27028103
97RPS6KA10.26345640
98GRK50.26339757
99PTK2B0.26153121
100PIK3CA0.23118093

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.07992487
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.84203695
3Allograft rejection_Homo sapiens_hsa053303.79923459
4Autoimmune thyroid disease_Homo sapiens_hsa053203.37861937
5Graft-versus-host disease_Homo sapiens_hsa053323.19394197
6Type I diabetes mellitus_Homo sapiens_hsa049402.80497691
7Proteasome_Homo sapiens_hsa030502.72827406
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31784986
9Sulfur metabolism_Homo sapiens_hsa009202.21695430
10Primary immunodeficiency_Homo sapiens_hsa053402.16591873
11Antigen processing and presentation_Homo sapiens_hsa046122.02230737
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87710706
13Rheumatoid arthritis_Homo sapiens_hsa053231.86263502
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84698164
15Oxidative phosphorylation_Homo sapiens_hsa001901.72079139
16Phototransduction_Homo sapiens_hsa047441.69582966
17Systemic lupus erythematosus_Homo sapiens_hsa053221.63553938
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62555847
19RNA polymerase_Homo sapiens_hsa030201.62169698
20Leishmaniasis_Homo sapiens_hsa051401.59754551
21Linoleic acid metabolism_Homo sapiens_hsa005911.56505026
22Ribosome_Homo sapiens_hsa030101.56149051
23Viral myocarditis_Homo sapiens_hsa054161.46028124
24Parkinsons disease_Homo sapiens_hsa050121.45623063
25Staphylococcus aureus infection_Homo sapiens_hsa051501.36687616
26Caffeine metabolism_Homo sapiens_hsa002321.36328420
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31152835
28RNA degradation_Homo sapiens_hsa030181.28595633
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27355752
30One carbon pool by folate_Homo sapiens_hsa006701.18971613
31Fanconi anemia pathway_Homo sapiens_hsa034601.18247911
32Nitrogen metabolism_Homo sapiens_hsa009101.17735856
33Homologous recombination_Homo sapiens_hsa034401.11275021
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08867003
35Hematopoietic cell lineage_Homo sapiens_hsa046401.07390589
36Tryptophan metabolism_Homo sapiens_hsa003801.05442671
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05096825
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03642317
39Arachidonic acid metabolism_Homo sapiens_hsa005901.02178474
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00331284
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.97657274
42Sulfur relay system_Homo sapiens_hsa041220.97042788
43NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97021837
44Protein export_Homo sapiens_hsa030600.96747564
45Propanoate metabolism_Homo sapiens_hsa006400.96638078
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92160931
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89628910
48Herpes simplex infection_Homo sapiens_hsa051680.85296549
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85281515
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83169329
51Purine metabolism_Homo sapiens_hsa002300.81968549
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80817194
53Alzheimers disease_Homo sapiens_hsa050100.80467100
54Nucleotide excision repair_Homo sapiens_hsa034200.78758681
55Basal transcription factors_Homo sapiens_hsa030220.75962831
56Ether lipid metabolism_Homo sapiens_hsa005650.74191779
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73819211
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70919684
59Peroxisome_Homo sapiens_hsa041460.70333152
60Mismatch repair_Homo sapiens_hsa034300.70310534
61Olfactory transduction_Homo sapiens_hsa047400.66671037
62Selenocompound metabolism_Homo sapiens_hsa004500.66114965
63Huntingtons disease_Homo sapiens_hsa050160.64880511
64Regulation of autophagy_Homo sapiens_hsa041400.64242435
65Retinol metabolism_Homo sapiens_hsa008300.64045306
66Cardiac muscle contraction_Homo sapiens_hsa042600.61580798
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.60922900
68Chemical carcinogenesis_Homo sapiens_hsa052040.57466775
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56533206
70Taste transduction_Homo sapiens_hsa047420.55931813
71Pyrimidine metabolism_Homo sapiens_hsa002400.54738187
72Non-homologous end-joining_Homo sapiens_hsa034500.53449950
73Collecting duct acid secretion_Homo sapiens_hsa049660.53403908
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53313934
75RNA transport_Homo sapiens_hsa030130.53079436
76Base excision repair_Homo sapiens_hsa034100.51036007
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50993673
78Fatty acid elongation_Homo sapiens_hsa000620.50273579
79ABC transporters_Homo sapiens_hsa020100.50020086
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48823936
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.48335108
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.45910854
83DNA replication_Homo sapiens_hsa030300.45766820
84Tuberculosis_Homo sapiens_hsa051520.45039813
85Fat digestion and absorption_Homo sapiens_hsa049750.42004058
86Spliceosome_Homo sapiens_hsa030400.41979573
87Butanoate metabolism_Homo sapiens_hsa006500.41084476
88Epstein-Barr virus infection_Homo sapiens_hsa051690.40995100
89Morphine addiction_Homo sapiens_hsa050320.40323313
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.39556339
91Legionellosis_Homo sapiens_hsa051340.39216831
92Toxoplasmosis_Homo sapiens_hsa051450.38857180
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38176566
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37409510
95Salivary secretion_Homo sapiens_hsa049700.37096925
96T cell receptor signaling pathway_Homo sapiens_hsa046600.36510934
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32780858
98Serotonergic synapse_Homo sapiens_hsa047260.31599470
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.30603271
100Metabolic pathways_Homo sapiens_hsa011000.30382902

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