EEF1GP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.17323373
2ribosomal small subunit assembly (GO:0000028)6.17146475
3translational termination (GO:0006415)5.91008578
4ribosomal small subunit biogenesis (GO:0042274)5.28418057
5maturation of SSU-rRNA (GO:0030490)5.17114297
6behavioral response to nicotine (GO:0035095)5.15303990
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.14082471
8translational elongation (GO:0006414)5.11847030
9cotranslational protein targeting to membrane (GO:0006613)5.02967998
10protein targeting to ER (GO:0045047)5.02626768
11chaperone-mediated protein transport (GO:0072321)4.87490020
12establishment of protein localization to endoplasmic reticulum (GO:0072599)4.79155723
13protein localization to endoplasmic reticulum (GO:0070972)4.76580170
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.75870692
15viral life cycle (GO:0019058)4.50097029
16energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38127075
17ATP synthesis coupled proton transport (GO:0015986)4.38127075
18cellular protein complex disassembly (GO:0043624)4.38080169
19protein neddylation (GO:0045116)4.32217950
20DNA deamination (GO:0045006)4.26903375
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.24378315
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.24194572
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.24194572
24protein complex biogenesis (GO:0070271)4.05652086
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.93705718
26NADH dehydrogenase complex assembly (GO:0010257)3.93705718
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.93705718
28translational initiation (GO:0006413)3.90802462
29ribosomal large subunit biogenesis (GO:0042273)3.81268884
30mitochondrial respiratory chain complex assembly (GO:0033108)3.76486658
31kynurenine metabolic process (GO:0070189)3.75915156
32protein complex disassembly (GO:0043241)3.68535168
33water-soluble vitamin biosynthetic process (GO:0042364)3.60077002
34respiratory chain complex IV assembly (GO:0008535)3.59970977
35translation (GO:0006412)3.56335979
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52906391
37cellular component biogenesis (GO:0044085)3.52358620
38macromolecular complex disassembly (GO:0032984)3.50581763
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41509386
40ribonucleoprotein complex biogenesis (GO:0022613)3.39560830
41protein targeting to membrane (GO:0006612)3.32374731
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.31223340
43substrate-independent telencephalic tangential migration (GO:0021826)3.31223340
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30877487
45response to pheromone (GO:0019236)3.30649745
46GTP biosynthetic process (GO:0006183)3.30063741
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.26525038
48cytochrome complex assembly (GO:0017004)3.25720825
49indole-containing compound catabolic process (GO:0042436)3.24968607
50indolalkylamine catabolic process (GO:0046218)3.24968607
51tryptophan catabolic process (GO:0006569)3.24968607
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23970436
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.22358726
54head development (GO:0060322)3.21089264
55nonmotile primary cilium assembly (GO:0035058)3.16334335
56negative regulation of telomere maintenance (GO:0032205)3.12425643
57negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.11155671
58base-excision repair, AP site formation (GO:0006285)3.08012403
59mRNA catabolic process (GO:0006402)3.04972601
60rRNA catabolic process (GO:0016075)3.03204142
61cell proliferation in forebrain (GO:0021846)3.00471488
62tryptophan metabolic process (GO:0006568)2.95986435
63CTP biosynthetic process (GO:0006241)2.94475729
64CTP metabolic process (GO:0046036)2.94475729
65UTP metabolic process (GO:0046051)2.93961349
66kidney morphogenesis (GO:0060993)2.93723725
67intracellular protein transmembrane import (GO:0044743)2.90815339
68respiratory electron transport chain (GO:0022904)2.86130736
69electron transport chain (GO:0022900)2.86069945
70somite development (GO:0061053)2.85905081
71endoderm formation (GO:0001706)2.85351027
72UTP biosynthetic process (GO:0006228)2.85204983
73negative regulation of T cell differentiation in thymus (GO:0033085)2.84543543
74rRNA modification (GO:0000154)2.82723695
75pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.81710584
76piRNA metabolic process (GO:0034587)2.81200556
77positive regulation of T cell apoptotic process (GO:0070234)2.80463529
78RNA catabolic process (GO:0006401)2.77044667
79rRNA metabolic process (GO:0016072)2.74124841
80cellular biogenic amine catabolic process (GO:0042402)2.73117399
81amine catabolic process (GO:0009310)2.73117399
82indolalkylamine metabolic process (GO:0006586)2.72869772
83pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.72767688
84rRNA processing (GO:0006364)2.71743854
85pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71620073
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70715818
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.68527985
88DNA methylation involved in gamete generation (GO:0043046)2.67948972
89purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67047640
90positive regulation of fatty acid transport (GO:2000193)2.65341482
91regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65181391
92positive regulation of prostaglandin secretion (GO:0032308)2.64808114
93pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.64054849
94ribosome biogenesis (GO:0042254)2.62996789
95protein-cofactor linkage (GO:0018065)2.62582420
96ubiquinone biosynthetic process (GO:0006744)2.57249130
97positive regulation of icosanoid secretion (GO:0032305)2.56193450
98synaptic transmission, cholinergic (GO:0007271)2.56118279
99ribonucleoside triphosphate biosynthetic process (GO:0009201)2.55857380
100hydrogen ion transmembrane transport (GO:1902600)2.54975942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.31912923
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.29421829
3EZH2_22144423_ChIP-Seq_EOC_Human3.83140326
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.72635740
5ZNF274_21170338_ChIP-Seq_K562_Hela3.17366890
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10754500
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.02961498
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.76493873
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64989939
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.64714738
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47381185
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20781335
13VDR_22108803_ChIP-Seq_LS180_Human2.19683875
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06227526
15VDR_23849224_ChIP-Seq_CD4+_Human1.84338419
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83524599
17MYC_18555785_ChIP-Seq_MESCs_Mouse1.82401499
18MYC_18940864_ChIP-ChIP_HL60_Human1.82042290
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81153564
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74323720
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68774569
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65580540
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61706618
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.59309420
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59217953
26FOXP3_21729870_ChIP-Seq_TREG_Human1.54732977
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48706255
28TTF2_22483619_ChIP-Seq_HELA_Human1.47674513
29GABP_19822575_ChIP-Seq_HepG2_Human1.45479397
30FUS_26573619_Chip-Seq_HEK293_Human1.44451607
31SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.34684201
32REST_18959480_ChIP-ChIP_MESCs_Mouse1.34681096
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34491356
34REST_21632747_ChIP-Seq_MESCs_Mouse1.33982537
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.32652836
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31692815
37EWS_26573619_Chip-Seq_HEK293_Human1.31177973
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.30955978
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30480579
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30440011
41ERA_21632823_ChIP-Seq_H3396_Human1.29849443
42ELK1_19687146_ChIP-ChIP_HELA_Human1.27157164
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26557453
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.26470472
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26438913
46TP53_22573176_ChIP-Seq_HFKS_Human1.24528009
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.23523074
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22154917
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.21025942
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20403141
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19829815
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17920488
53XRN2_22483619_ChIP-Seq_HELA_Human1.17556504
54IGF1R_20145208_ChIP-Seq_DFB_Human1.16622137
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16465134
56AR_20517297_ChIP-Seq_VCAP_Human1.16111828
57NANOG_20526341_ChIP-Seq_ESCs_Human1.16026317
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.14576016
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14576016
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14564334
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.13178179
62NCOR_22424771_ChIP-Seq_293T_Human1.09674952
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09240997
64MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08956464
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07349679
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.06142349
67TAF2_19829295_ChIP-Seq_ESCs_Human1.04419300
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04054792
69P53_21459846_ChIP-Seq_SAOS-2_Human1.03682401
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03370894
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02881284
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02784984
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01975879
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01843810
75HOXB7_26014856_ChIP-Seq_BT474_Human1.01799788
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01329043
77PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99371143
78THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99341546
79MYC_19829295_ChIP-Seq_ESCs_Human0.98424229
80IRF1_19129219_ChIP-ChIP_H3396_Human0.98163429
81FLI1_27457419_Chip-Seq_LIVER_Mouse0.96833722
82STAT1_20625510_ChIP-Seq_HELA_Human0.94906849
83EED_16625203_ChIP-ChIP_MESCs_Mouse0.94507397
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94260764
85BCL6_27268052_Chip-Seq_Bcells_Human0.93842112
86FOXH1_21741376_ChIP-Seq_ESCs_Human0.92547974
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.92055389
88P300_19829295_ChIP-Seq_ESCs_Human0.91991344
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89950072
90SOX2_19829295_ChIP-Seq_ESCs_Human0.89192511
91NANOG_19829295_ChIP-Seq_ESCs_Human0.89192511
92E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88664603
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87910724
94FOXP1_21924763_ChIP-Seq_HESCs_Human0.87572876
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.85684930
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.85254224
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85168220
98MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85005773
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83374766
100ER_23166858_ChIP-Seq_MCF-7_Human0.80303129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.89671708
2MP0009379_abnormal_foot_pigmentation3.84598338
3MP0003787_abnormal_imprinting3.48440210
4MP0002653_abnormal_ependyma_morphology3.24001415
5MP0002163_abnormal_gland_morphology3.03118946
6MP0003122_maternal_imprinting3.00781230
7MP0008877_abnormal_DNA_methylation2.88907873
8MP0003646_muscle_fatigue2.77303195
9MP0008875_abnormal_xenobiotic_pharmacok2.56996549
10MP0002837_dystrophic_cardiac_calcinosis2.56501862
11MP0003121_genomic_imprinting2.42189844
12MP0004142_abnormal_muscle_tone2.40637440
13MP0008789_abnormal_olfactory_epithelium2.24618162
14MP0002102_abnormal_ear_morphology2.22806973
15MP0005646_abnormal_pituitary_gland2.19333324
16MP0001485_abnormal_pinna_reflex2.18867612
17MP0003878_abnormal_ear_physiology2.12787040
18MP0005377_hearing/vestibular/ear_phenot2.12787040
19MP0003136_yellow_coat_color2.06918542
20MP0006276_abnormal_autonomic_nervous2.01280192
21MP0001293_anophthalmia1.91567955
22MP0005379_endocrine/exocrine_gland_phen1.89752614
23MP0005645_abnormal_hypothalamus_physiol1.82225771
24MP0004147_increased_porphyrin_level1.77659742
25MP0002138_abnormal_hepatobiliary_system1.75844318
26MP0005499_abnormal_olfactory_system1.68490344
27MP0005394_taste/olfaction_phenotype1.68490344
28MP0008775_abnormal_heart_ventricle1.65972830
29MP0006072_abnormal_retinal_apoptosis1.60036503
30MP0002938_white_spotting1.56195265
31MP0005551_abnormal_eye_electrophysiolog1.54349840
32MP0000049_abnormal_middle_ear1.49057947
33MP0004885_abnormal_endolymph1.45958710
34MP0000372_irregular_coat_pigmentation1.45952179
35MP0003123_paternal_imprinting1.45608063
36MP0004133_heterotaxia1.40761280
37MP0010030_abnormal_orbit_morphology1.40431589
38MP0008872_abnormal_physiological_respon1.40104268
39MP0000631_abnormal_neuroendocrine_gland1.37835205
40MP0002272_abnormal_nervous_system1.34346199
41MP0002234_abnormal_pharynx_morphology1.32853660
42MP0000778_abnormal_nervous_system1.29223914
43MP0001986_abnormal_taste_sensitivity1.24727588
44MP0001529_abnormal_vocalization1.23087407
45MP0005195_abnormal_posterior_eye1.22792649
46MP0001968_abnormal_touch/_nociception1.22640643
47MP0004742_abnormal_vestibular_system1.20252110
48MP0008058_abnormal_DNA_repair1.15936644
49MP0002876_abnormal_thyroid_physiology1.14684023
50MP0002733_abnormal_thermal_nociception1.12967462
51MP0003283_abnormal_digestive_organ1.11713879
52MP0009046_muscle_twitch1.10432927
53MP0002160_abnormal_reproductive_system1.07720802
54MP0005389_reproductive_system_phenotype1.04541168
55MP0005084_abnormal_gallbladder_morpholo1.04187848
56MP0001486_abnormal_startle_reflex1.02964177
57MP0009745_abnormal_behavioral_response1.02541623
58MP0005167_abnormal_blood-brain_barrier1.00012903
59MP0002557_abnormal_social/conspecific_i0.99722740
60MP0003693_abnormal_embryo_hatching0.99121822
61MP0001970_abnormal_pain_threshold0.98307166
62MP0003567_abnormal_fetal_cardiomyocyte0.96165410
63MP0000026_abnormal_inner_ear0.94200703
64MP0003011_delayed_dark_adaptation0.93453525
65MP0004145_abnormal_muscle_electrophysio0.93214472
66MP0002752_abnormal_somatic_nervous0.92948107
67MP0003786_premature_aging0.90226751
68MP0001984_abnormal_olfaction0.90137902
69MP0001963_abnormal_hearing_physiology0.88185968
70MP0000427_abnormal_hair_cycle0.87784495
71MP0000955_abnormal_spinal_cord0.86508724
72MP0001501_abnormal_sleep_pattern0.85502335
73MP0002572_abnormal_emotion/affect_behav0.84317825
74MP0002736_abnormal_nociception_after0.83984752
75MP0002063_abnormal_learning/memory/cond0.83579363
76MP0002067_abnormal_sensory_capabilities0.82947326
77MP0005253_abnormal_eye_physiology0.82349828
78MP0001286_abnormal_eye_development0.80869744
79MP0002210_abnormal_sex_determination0.78446466
80MP0003195_calcinosis0.77856982
81MP0002734_abnormal_mechanical_nocicepti0.77465021
82MP0003879_abnormal_hair_cell0.76010465
83MP0003635_abnormal_synaptic_transmissio0.74618879
84MP0002638_abnormal_pupillary_reflex0.74085079
85MP0002735_abnormal_chemical_nociception0.73941866
86MP0002233_abnormal_nose_morphology0.71531001
87MP0002184_abnormal_innervation0.71449543
88MP0003938_abnormal_ear_development0.71220704
89MP0001919_abnormal_reproductive_system0.71208080
90MP0001905_abnormal_dopamine_level0.68619302
91MP0002064_seizures0.68320128
92MP0001145_abnormal_male_reproductive0.67169451
93MP0003119_abnormal_digestive_system0.66684477
94MP0000653_abnormal_sex_gland0.65334542
95MP0005636_abnormal_mineral_homeostasis0.65230768
96MP0003186_abnormal_redox_activity0.64966328
97MP0002229_neurodegeneration0.64854348
98MP0002095_abnormal_skin_pigmentation0.64613044
99MP0006036_abnormal_mitochondrial_physio0.64549731
100MP0001502_abnormal_circadian_rhythm0.63620253

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.70965860
2Reticulocytopenia (HP:0001896)4.37609102
3Pancreatic cysts (HP:0001737)4.04879221
4True hermaphroditism (HP:0010459)3.71496033
5Abnormality of cells of the erythroid lineage (HP:0012130)3.64854948
6Acute necrotizing encephalopathy (HP:0006965)3.56429331
7Abnormality of midbrain morphology (HP:0002418)3.55771432
8Molar tooth sign on MRI (HP:0002419)3.55771432
9Mitochondrial inheritance (HP:0001427)3.44906340
10Increased CSF lactate (HP:0002490)3.20756718
11Nephronophthisis (HP:0000090)3.16956144
12Type II lissencephaly (HP:0007260)3.09903506
13Abnormal mitochondria in muscle tissue (HP:0008316)3.09443549
14Abnormality of DNA repair (HP:0003254)3.00423087
15Hepatocellular necrosis (HP:0001404)2.99624139
16Acute encephalopathy (HP:0006846)2.99487340
17Progressive macrocephaly (HP:0004481)2.98356835
18Pendular nystagmus (HP:0012043)2.88648938
19Medial flaring of the eyebrow (HP:0010747)2.85895480
20Oligodactyly (hands) (HP:0001180)2.85644810
21Cystic liver disease (HP:0006706)2.80613190
22Sclerocornea (HP:0000647)2.80239821
23Abnormal number of erythroid precursors (HP:0012131)2.76998702
24Lipid accumulation in hepatocytes (HP:0006561)2.70701286
25Chronic hepatic failure (HP:0100626)2.61054083
26Hepatic necrosis (HP:0002605)2.60563165
27Increased hepatocellular lipid droplets (HP:0006565)2.59399645
28Abnormality of the renal medulla (HP:0100957)2.58792088
29Anencephaly (HP:0002323)2.58181721
30Macrocytic anemia (HP:0001972)2.54545540
31Absent thumb (HP:0009777)2.52987034
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51521647
33Congenital stationary night blindness (HP:0007642)2.46240531
34Abnormal rod and cone electroretinograms (HP:0008323)2.46076182
35Gait imbalance (HP:0002141)2.43208896
36Oligodactyly (HP:0012165)2.41240906
37Anophthalmia (HP:0000528)2.38051808
38Congenital primary aphakia (HP:0007707)2.35407738
39Postaxial foot polydactyly (HP:0001830)2.34581187
40Decreased central vision (HP:0007663)2.34146931
41Optic disc pallor (HP:0000543)2.33695761
42Abnormality of the labia minora (HP:0012880)2.33201044
43Congenital hepatic fibrosis (HP:0002612)2.30395657
44Nephrogenic diabetes insipidus (HP:0009806)2.27013169
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.26315768
46Increased serum lactate (HP:0002151)2.23711169
47Type 2 muscle fiber atrophy (HP:0003554)2.23173432
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.21676727
49Colon cancer (HP:0003003)2.21303071
50Abolished electroretinogram (ERG) (HP:0000550)2.20020202
51Abnormality of the renal cortex (HP:0011035)2.17114112
52Polyuria (HP:0000103)2.14663845
53Entropion (HP:0000621)2.13233288
54Pallor (HP:0000980)2.12065327
55Elevated erythrocyte sedimentation rate (HP:0003565)2.12061254
56Cerebral edema (HP:0002181)2.11367609
57Polydipsia (HP:0001959)2.10857963
58Abnormal drinking behavior (HP:0030082)2.10857963
59Cerebellar dysplasia (HP:0007033)2.08468786
60Myokymia (HP:0002411)2.07854547
61Stenosis of the external auditory canal (HP:0000402)2.07370084
62Hyperglycinemia (HP:0002154)2.04892112
63Asplenia (HP:0001746)2.00936481
64Optic nerve hypoplasia (HP:0000609)2.00596126
65Abnormality of magnesium homeostasis (HP:0004921)2.00501109
66Horseshoe kidney (HP:0000085)1.99971721
67Supernumerary spleens (HP:0009799)1.96099711
68Renal Fanconi syndrome (HP:0001994)1.94876215
69Occipital encephalocele (HP:0002085)1.94201322
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94048741
71Hypomagnesemia (HP:0002917)1.94008550
72Hyperglycinuria (HP:0003108)1.93018572
73Neoplasm of the adrenal cortex (HP:0100641)1.92296937
74Septo-optic dysplasia (HP:0100842)1.91501890
75Pachygyria (HP:0001302)1.90201692
76Male pseudohermaphroditism (HP:0000037)1.89898113
77Attenuation of retinal blood vessels (HP:0007843)1.89780904
78Muscle fiber atrophy (HP:0100295)1.89243204
79Postaxial hand polydactyly (HP:0001162)1.89164182
80Lactic acidosis (HP:0003128)1.84648575
81Respiratory failure (HP:0002878)1.83273324
82Adrenal hypoplasia (HP:0000835)1.82661844
83Preaxial hand polydactyly (HP:0001177)1.82476302
84Abnormality of the renal collecting system (HP:0004742)1.79867594
85Lissencephaly (HP:0001339)1.79623387
86Rib fusion (HP:0000902)1.79317326
87Agitation (HP:0000713)1.78921735
88Abnormal biliary tract physiology (HP:0012439)1.78718714
89Bile duct proliferation (HP:0001408)1.78718714
90Growth hormone deficiency (HP:0000824)1.76844171
91Increased intramyocellular lipid droplets (HP:0012240)1.76814469
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.76770791
93Absent/shortened dynein arms (HP:0200106)1.76770791
94Optic nerve coloboma (HP:0000588)1.76192853
95Respiratory difficulties (HP:0002880)1.75970930
96Hypoplasia of the ulna (HP:0003022)1.75793822
973-Methylglutaconic aciduria (HP:0003535)1.75610288
98Ectopic kidney (HP:0000086)1.75007784
99Severe visual impairment (HP:0001141)1.74236386
100Abnormality of abdominal situs (HP:0011620)1.74042858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.28326375
2STK163.41596955
3CDK193.30292551
4NUAK12.94652471
5WNK42.88012416
6FRK2.87076391
7BCKDK2.85927014
8GRK12.55790315
9TXK2.54340843
10DYRK22.49570208
11MAP4K22.06308782
12ADRBK22.06171727
13VRK21.85362871
14WNK31.82056678
15PIK3CA1.71774449
16TNIK1.71208769
17BMPR1B1.66142505
18ZAK1.65331825
19STK391.58277375
20INSRR1.55503974
21PINK11.41311761
22MST41.40858662
23OXSR11.32433919
24PHKG11.28353066
25PHKG21.28353066
26NEK11.20967187
27PDK21.16452879
28TLK11.14692552
29PASK1.10484073
30CASK1.07893441
31TGFBR11.05471424
32TRIM281.03000158
33EIF2AK30.97164612
34TAF10.96271874
35PRKCG0.95951079
36PAK30.95483889
37MAP3K90.95479973
38VRK10.94495362
39TEC0.93034045
40STK110.92484120
41TAOK30.89999852
42PRKCQ0.86893237
43AURKA0.84567509
44DAPK20.82216473
45CSNK1G20.82042699
46PRKD30.81547520
47NEK20.81180766
48LRRK20.80150368
49CSNK1G30.80143405
50MAP2K20.78067523
51RPS6KA60.75994955
52KIT0.75600215
53EPHB20.74971185
54CDC70.74830253
55PRKCH0.71936051
56SRPK10.70243677
57DAPK30.68966076
58MATK0.68415719
59EPHA40.67642358
60IKBKB0.67400653
61NTRK20.65899740
62EIF2AK10.65173997
63PLK30.63472750
64NME10.62711243
65MAPK130.61473993
66CSNK1G10.60281695
67MAP3K110.60176479
68ADRBK10.60035970
69PLK20.59818064
70CAMK10.59370943
71CSNK1A1L0.58646010
72GRK50.58544883
73CSNK2A20.58103450
74RPS6KC10.57763918
75RPS6KL10.57763918
76PRKACA0.57467277
77CSNK1A10.57243564
78ACVR1B0.56637591
79PLK40.56295397
80AURKB0.54375249
81PRKCD0.51442912
82CAMKK20.50696257
83DYRK30.50548368
84CSNK1E0.48758830
85TYRO30.48053482
86MINK10.46140956
87ATR0.45977607
88RPS6KA50.44626571
89PRKCA0.43674950
90SIK20.42297035
91CSNK2A10.41320805
92SGK10.39753601
93CHEK20.39484266
94ITK0.36749466
95PRKCE0.36077061
96PRKCI0.35542604
97DAPK10.34161800
98OBSCN0.33024395
99RPS6KB20.31611271
100CAMKK10.31549561

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.46928140
2Oxidative phosphorylation_Homo sapiens_hsa001903.42581444
3Caffeine metabolism_Homo sapiens_hsa002323.09965349
4Parkinsons disease_Homo sapiens_hsa050122.77014984
5RNA polymerase_Homo sapiens_hsa030202.41911984
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23953854
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17501956
8Linoleic acid metabolism_Homo sapiens_hsa005912.13795594
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.11155119
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06971709
11Huntingtons disease_Homo sapiens_hsa050162.04810950
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95437956
13Phototransduction_Homo sapiens_hsa047441.91323939
14Alzheimers disease_Homo sapiens_hsa050101.80834891
15Cardiac muscle contraction_Homo sapiens_hsa042601.76459179
16Homologous recombination_Homo sapiens_hsa034401.73009616
17RNA degradation_Homo sapiens_hsa030181.71008251
18Basal transcription factors_Homo sapiens_hsa030221.69855795
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.58492334
20Sulfur relay system_Homo sapiens_hsa041221.58384237
21Proteasome_Homo sapiens_hsa030501.56671498
22Nucleotide excision repair_Homo sapiens_hsa034201.55462179
23Tryptophan metabolism_Homo sapiens_hsa003801.54551642
24Protein export_Homo sapiens_hsa030601.49181316
25Pyrimidine metabolism_Homo sapiens_hsa002401.44925296
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44631760
27Butanoate metabolism_Homo sapiens_hsa006501.41560915
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38360545
29Fanconi anemia pathway_Homo sapiens_hsa034601.34462226
30Base excision repair_Homo sapiens_hsa034101.34001892
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32524337
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31066485
33One carbon pool by folate_Homo sapiens_hsa006701.28788370
34Peroxisome_Homo sapiens_hsa041461.27981935
35Propanoate metabolism_Homo sapiens_hsa006401.19061815
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18341544
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.14107687
38Fat digestion and absorption_Homo sapiens_hsa049751.08079734
39Chemical carcinogenesis_Homo sapiens_hsa052041.06752656
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03792218
41Mismatch repair_Homo sapiens_hsa034301.02674587
42Fatty acid degradation_Homo sapiens_hsa000711.01867036
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99466458
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99372543
45Purine metabolism_Homo sapiens_hsa002300.99311704
46Asthma_Homo sapiens_hsa053100.97613149
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.97160775
48Steroid biosynthesis_Homo sapiens_hsa001000.95480506
49Nitrogen metabolism_Homo sapiens_hsa009100.95028380
50Nicotine addiction_Homo sapiens_hsa050330.94396915
51Arachidonic acid metabolism_Homo sapiens_hsa005900.93841682
52Ether lipid metabolism_Homo sapiens_hsa005650.93184834
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91810405
54Selenocompound metabolism_Homo sapiens_hsa004500.90365449
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88398796
56Sulfur metabolism_Homo sapiens_hsa009200.87753142
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87195341
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.86032886
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84440080
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84206225
61DNA replication_Homo sapiens_hsa030300.84164540
62Metabolic pathways_Homo sapiens_hsa011000.83073165
63Retinol metabolism_Homo sapiens_hsa008300.80718043
64Arginine and proline metabolism_Homo sapiens_hsa003300.77164832
65Glycerolipid metabolism_Homo sapiens_hsa005610.75488083
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75430297
67Basal cell carcinoma_Homo sapiens_hsa052170.73357181
68Collecting duct acid secretion_Homo sapiens_hsa049660.73302401
69Hedgehog signaling pathway_Homo sapiens_hsa043400.71015337
70Starch and sucrose metabolism_Homo sapiens_hsa005000.70623242
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.69702052
72Spliceosome_Homo sapiens_hsa030400.64996980
73Vitamin B6 metabolism_Homo sapiens_hsa007500.64695745
74Pyruvate metabolism_Homo sapiens_hsa006200.64493549
75Folate biosynthesis_Homo sapiens_hsa007900.64254658
76RNA transport_Homo sapiens_hsa030130.64025169
77Non-homologous end-joining_Homo sapiens_hsa034500.61222574
78Taste transduction_Homo sapiens_hsa047420.60433692
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58821133
80Ovarian steroidogenesis_Homo sapiens_hsa049130.57818931
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.56701023
82beta-Alanine metabolism_Homo sapiens_hsa004100.55836000
83Fatty acid metabolism_Homo sapiens_hsa012120.53678427
84Morphine addiction_Homo sapiens_hsa050320.51643709
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51394789
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48710481
87Olfactory transduction_Homo sapiens_hsa047400.43937852
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41595646
89Primary immunodeficiency_Homo sapiens_hsa053400.38447818
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.38209534
91Glutathione metabolism_Homo sapiens_hsa004800.36025311
92Fatty acid elongation_Homo sapiens_hsa000620.32820970
93Insulin secretion_Homo sapiens_hsa049110.32791401
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.31718700
95Vitamin digestion and absorption_Homo sapiens_hsa049770.30354168
96Serotonergic synapse_Homo sapiens_hsa047260.29549086
97GABAergic synapse_Homo sapiens_hsa047270.27516223
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.27174134
99Regulation of autophagy_Homo sapiens_hsa041400.26139716
100Glutamatergic synapse_Homo sapiens_hsa047240.23623728

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