ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.70508929
2	ribosomal small subunit assembly (GO:0000028)	5.42792801
3	ribosomal small subunit biogenesis (GO:0042274)	5.19788735
4	viral transcription (GO:0019083)	5.13740017
5	translational termination (GO:0006415)	4.87852538
6	behavioral response to nicotine (GO:0035095)	4.68564518
7	maturation of SSU-rRNA (GO:0030490)	4.48957635
8	translational elongation (GO:0006414)	4.44495155
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.31876744
10	water-soluble vitamin biosynthetic process (GO:0042364)	4.23269478
11	cotranslational protein targeting to membrane (GO:0006613)	4.22609393
12	protein targeting to ER (GO:0045047)	4.21440645
13	ATP synthesis coupled proton transport (GO:0015986)	4.16728442
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.16728442
15	protein localization to endoplasmic reticulum (GO:0070972)	4.03977535
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.00178024
17	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.92008521
18	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.87702230
19	ribosomal large subunit biogenesis (GO:0042273)	3.83651615
20	preassembly of GPI anchor in ER membrane (GO:0016254)	3.77703295
21	viral life cycle (GO:0019058)	3.72389557
22	chaperone-mediated protein transport (GO:0072321)	3.70373805
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.65557568
24	cellular protein complex disassembly (GO:0043624)	3.54731706
25	protein complex biogenesis (GO:0070271)	3.53071026
26	L-fucose catabolic process (GO:0042355)	3.44498803
27	fucose catabolic process (GO:0019317)	3.44498803
28	L-fucose metabolic process (GO:0042354)	3.44498803
29	ncRNA 3-end processing (GO:0043628)	3.41268424
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.39819820
31	protein neddylation (GO:0045116)	3.36469094
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.31767027
33	NADH dehydrogenase complex assembly (GO:0010257)	3.31767027
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.31767027
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.31030050
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.31030050
37	translational initiation (GO:0006413)	3.30301778
38	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.29114585
39	response to pheromone (GO:0019236)	3.24149511
40	kynurenine metabolic process (GO:0070189)	3.18412209
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.17871541
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.17721589
43	cellular component biogenesis (GO:0044085)	3.15592763
44	piRNA metabolic process (GO:0034587)	3.14329706
45	electron transport chain (GO:0022900)	3.13928892
46	translation (GO:0006412)	3.13897193
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13212219
48	positive regulation of prostaglandin secretion (GO:0032308)	3.09842114
49	respiratory electron transport chain (GO:0022904)	3.08728119
50	indolalkylamine metabolic process (GO:0006586)	3.07640515
51	pseudouridine synthesis (GO:0001522)	3.06841935
52	cytidine deamination (GO:0009972)	3.06388279
53	cytidine metabolic process (GO:0046087)	3.06388279
54	cytidine catabolic process (GO:0006216)	3.06388279
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.02304725
56	positive regulation of defense response to virus by host (GO:0002230)	2.97301549
57	indole-containing compound catabolic process (GO:0042436)	2.96142249
58	indolalkylamine catabolic process (GO:0046218)	2.96142249
59	tryptophan catabolic process (GO:0006569)	2.96142249
60	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.95847360
61	GPI anchor metabolic process (GO:0006505)	2.94116429
62	GPI anchor biosynthetic process (GO:0006506)	2.90243597
63	protein complex disassembly (GO:0043241)	2.88428709
64	tryptophan metabolic process (GO:0006568)	2.82212485
65	respiratory chain complex IV assembly (GO:0008535)	2.82093877
66	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.82061074
67	inositol phosphate dephosphorylation (GO:0046855)	2.79662824
68	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.79662824
69	GTP biosynthetic process (GO:0006183)	2.78865634
70	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.77241840
71	cytochrome complex assembly (GO:0017004)	2.74692971
72	macromolecular complex disassembly (GO:0032984)	2.73444178
73	mannosylation (GO:0097502)	2.73111092
74	positive regulation of fatty acid transport (GO:2000193)	2.72287982
75	protein-cofactor linkage (GO:0018065)	2.71542770
76	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.69551386
77	ubiquinone biosynthetic process (GO:0006744)	2.69427913
78	endoderm formation (GO:0001706)	2.68551584
79	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.65806418
80	termination of RNA polymerase III transcription (GO:0006386)	2.65416245
81	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.65416245
82	protein targeting to membrane (GO:0006612)	2.64374067
83	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.63771394
84	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.62801462
85	maturation of 5.8S rRNA (GO:0000460)	2.62131758
86	branched-chain amino acid catabolic process (GO:0009083)	2.59755735
87	base-excision repair, AP site formation (GO:0006285)	2.59729816
88	ATP biosynthetic process (GO:0006754)	2.59004792
89	rRNA processing (GO:0006364)	2.58580489
90	inositol phosphate catabolic process (GO:0071545)	2.57556154
91	tRNA processing (GO:0008033)	2.57279643
92	rRNA metabolic process (GO:0016072)	2.56514388
93	positive regulation of icosanoid secretion (GO:0032305)	2.53710757
94	male meiosis I (GO:0007141)	2.53146985
95	mRNA catabolic process (GO:0006402)	2.52462821
96	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.50320531
97	protein polyglutamylation (GO:0018095)	2.48942861
98	rRNA modification (GO:0000154)	2.47081479
99	synaptic transmission, cholinergic (GO:0007271)	2.46697197
100	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.46257930

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.31967382
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.78286176
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.54510178
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.40598579
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03813118
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.92197014
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.84148045
8	VDR_22108803_ChIP-Seq_LS180_Human	2.83777037
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82733941
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.71896868
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.51545866
12	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.30063272
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.26014644
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.14233410
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.10780513
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06469093
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.95270094
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.90008354
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86479736
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85292736
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.82260256
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.81306886
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.81181612
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.76110517
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.75879696
26	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.75502232
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.69159669
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66158258
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59350031
30	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.57556278
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53987111
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50925455
33	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.49435550
34	AR_20517297_ChIP-Seq_VCAP_Human	1.41563151
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.39662806
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.39485190
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38328840
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.37571571
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37330472
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37330472
41	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.33710829
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33580257
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32594480
44	TAF2_19829295_ChIP-Seq_ESCs_Human	1.31947615
45	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.31296674
46	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.30866265
47	GATA3_26560356_Chip-Seq_TH2_Human	1.27347493
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26961587
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26888317
50	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.26361086
51	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.25247206
52	EWS_26573619_Chip-Seq_HEK293_Human	1.25218549
53	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.25158241
54	ERA_21632823_ChIP-Seq_H3396_Human	1.23673971
55	BCL6_27268052_Chip-Seq_Bcells_Human	1.23281103
56	FUS_26573619_Chip-Seq_HEK293_Human	1.23024811
57	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21336252
58	NCOR_22424771_ChIP-Seq_293T_Human	1.20915954
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.20538485
60	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.20375090
61	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.19365624
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.18613406
63	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16918148
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.14891052
65	STAT1_20625510_ChIP-Seq_HELA_Human	1.14383148
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12714318
67	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12714318
68	MYC_19829295_ChIP-Seq_ESCs_Human	1.11867286
69	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.10826332
70	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10593460
71	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.10237378
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08071968
73	TTF2_22483619_ChIP-Seq_HELA_Human	1.07592686
74	P300_27268052_Chip-Seq_Bcells_Human	1.06844159
75	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05359158
76	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04778711
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04729551
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04685100
79	ER_23166858_ChIP-Seq_MCF-7_Human	1.04603088
80	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.03884984
81	GABP_19822575_ChIP-Seq_HepG2_Human	1.03879337
82	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.03499572
83	P53_21459846_ChIP-Seq_SAOS-2_Human	1.02766956
84	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.01229310
85	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00560194
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99172336
87	E2F1_20622854_ChIP-Seq_HELA_Human	0.98863139
88	RAC3_21632823_ChIP-Seq_H3396_Human	0.98107940
89	ERG_20517297_ChIP-Seq_VCAP_Human	0.97812971
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97461296
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.97461296
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97243128
93	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95959804
94	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.95716830
95	OCT4_20526341_ChIP-Seq_ESCs_Human	0.95694356
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93361257
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93197854
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92598075
99	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.90142172
100	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.90030146

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.49546722
2	MP0009379_abnormal_foot_pigmentation	3.16362819
3	MP0005671_abnormal_response_to	2.83649206
4	MP0003646_muscle_fatigue	2.82845539
5	MP0008877_abnormal_DNA_methylation	2.69837906
6	MP0008875_abnormal_xenobiotic_pharmacok	2.60744997
7	MP0003011_delayed_dark_adaptation	2.45111860
8	MP0002837_dystrophic_cardiac_calcinosis	2.26353108
9	MP0006072_abnormal_retinal_apoptosis	2.23360953
10	MP0001986_abnormal_taste_sensitivity	2.15212718
11	MP0004145_abnormal_muscle_electrophysio	2.13633287
12	MP0002102_abnormal_ear_morphology	2.13580132
13	MP0008872_abnormal_physiological_respon	2.11748615
14	MP0002138_abnormal_hepatobiliary_system	2.11177608
15	MP0002876_abnormal_thyroid_physiology	1.96715904
16	MP0005646_abnormal_pituitary_gland	1.94683428
17	MP0001835_abnormal_antigen_presentation	1.91929778
18	MP0003195_calcinosis	1.88220876
19	MP0004147_increased_porphyrin_level	1.87394376
20	MP0005645_abnormal_hypothalamus_physiol	1.77511755
21	MP0005551_abnormal_eye_electrophysiolog	1.71342658
22	MP0004885_abnormal_endolymph	1.69385878
23	MP0001968_abnormal_touch/_nociception	1.66290234
24	MP0001800_abnormal_humoral_immune	1.62305836
25	MP0002148_abnormal_hypersensitivity_rea	1.56684950
26	MP0005377_hearing/vestibular/ear_phenot	1.54183340
27	MP0003878_abnormal_ear_physiology	1.54183340
28	MP0002163_abnormal_gland_morphology	1.52670956
29	MP0005389_reproductive_system_phenotype	1.50975547
30	MP0003787_abnormal_imprinting	1.50329969
31	MP0005084_abnormal_gallbladder_morpholo	1.48384762
32	MP0000685_abnormal_immune_system	1.48122648
33	MP0002736_abnormal_nociception_after	1.46214061
34	MP0006276_abnormal_autonomic_nervous	1.43249778
35	MP0005075_abnormal_melanosome_morpholog	1.43213483
36	MP0004142_abnormal_muscle_tone	1.42504694
37	MP0003724_increased_susceptibility_to	1.40333479
38	MP0001873_stomach_inflammation	1.38400106
39	MP0001919_abnormal_reproductive_system	1.37923219
40	MP0008775_abnormal_heart_ventricle	1.35229357
41	MP0005000_abnormal_immune_tolerance	1.34044342
42	MP0008789_abnormal_olfactory_epithelium	1.33575572
43	MP0002095_abnormal_skin_pigmentation	1.33560527
44	MP0002723_abnormal_immune_serum	1.32985075
45	MP0009764_decreased_sensitivity_to	1.30148844
46	MP0009785_altered_susceptibility_to	1.29026368
47	MP0001905_abnormal_dopamine_level	1.27499258
48	MP0002160_abnormal_reproductive_system	1.26285771
49	MP0005253_abnormal_eye_physiology	1.25425148
50	MP0002277_abnormal_respiratory_mucosa	1.23795663
51	MP0003879_abnormal_hair_cell	1.23673524
52	MP0000372_irregular_coat_pigmentation	1.20070536
53	MP0005387_immune_system_phenotype	1.19972263
54	MP0001790_abnormal_immune_system	1.19972263
55	MP0002272_abnormal_nervous_system	1.19495101
56	MP0006082_CNS_inflammation	1.18850255
57	MP0001529_abnormal_vocalization	1.15470356
58	MP0001501_abnormal_sleep_pattern	1.10510926
59	MP0002452_abnormal_antigen_presenting	1.08052463
60	MP0002653_abnormal_ependyma_morphology	1.07893377
61	MP0001819_abnormal_immune_cell	1.07672277
62	MP0002420_abnormal_adaptive_immunity	1.06989940
63	MP0006036_abnormal_mitochondrial_physio	1.05766171
64	MP0008995_early_reproductive_senescence	1.03931892
65	MP0004133_heterotaxia	1.03354244
66	MP0003252_abnormal_bile_duct	1.03211454
67	MP0003866_abnormal_defecation	1.02665048
68	MP0005410_abnormal_fertilization	1.00862034
69	MP0009333_abnormal_splenocyte_physiolog	0.99275861
70	MP0005085_abnormal_gallbladder_physiolo	0.99118595
71	MP0000631_abnormal_neuroendocrine_gland	0.97478526
72	MP0002234_abnormal_pharynx_morphology	0.97212401
73	MP0003763_abnormal_thymus_physiology	0.94439355
74	MP0003693_abnormal_embryo_hatching	0.93570958
75	MP0001663_abnormal_digestive_system	0.93487216
76	MP0003121_genomic_imprinting	0.92765056
77	MP0003806_abnormal_nucleotide_metabolis	0.92277726
78	MP0002638_abnormal_pupillary_reflex	0.91641026
79	MP0003786_premature_aging	0.89755889
80	MP0003436_decreased_susceptibility_to	0.89657692
81	MP0003186_abnormal_redox_activity	0.89292785
82	MP0009745_abnormal_behavioral_response	0.88873816
83	MP0005379_endocrine/exocrine_gland_phen	0.88445346
84	MP0002933_joint_inflammation	0.87607748
85	MP0001764_abnormal_homeostasis	0.87603308
86	MP0008058_abnormal_DNA_repair	0.85580283
87	MP0001293_anophthalmia	0.85102993
88	MP0001984_abnormal_olfaction	0.82648557
89	MP0010155_abnormal_intestine_physiology	0.81912322
90	MP0005636_abnormal_mineral_homeostasis	0.81711849
91	MP0000689_abnormal_spleen_morphology	0.81643665
92	MP0002733_abnormal_thermal_nociception	0.81463010
93	MP0000716_abnormal_immune_system	0.79887246
94	MP0004043_abnormal_pH_regulation	0.77571622
95	MP0001845_abnormal_inflammatory_respons	0.76615329
96	MP0009046_muscle_twitch	0.76266213
97	MP0000230_abnormal_systemic_arterial	0.74380745
98	MP0005499_abnormal_olfactory_system	0.73273573
99	MP0005394_taste/olfaction_phenotype	0.73273573
100	MP0005025_abnormal_response_to	0.72638339

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.02001921
2	Mitochondrial inheritance (HP:0001427)	3.76176597
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.61975451
4	Acute encephalopathy (HP:0006846)	3.53739503
5	Increased CSF lactate (HP:0002490)	3.50716176
6	Congenital stationary night blindness (HP:0007642)	3.46984184
7	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.43813934
8	Progressive macrocephaly (HP:0004481)	3.36475283
9	Pancreatic cysts (HP:0001737)	3.35849102
10	Abnormality of cells of the erythroid lineage (HP:0012130)	3.35778518
11	Hepatocellular necrosis (HP:0001404)	3.35489836
12	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.30839677
13	Lipid accumulation in hepatocytes (HP:0006561)	3.26697402
14	Attenuation of retinal blood vessels (HP:0007843)	3.25855746
15	Abnormal number of erythroid precursors (HP:0012131)	3.23688057
16	Pancreatic fibrosis (HP:0100732)	3.18167491
17	IgG deficiency (HP:0004315)	3.14357077
18	Type 2 muscle fiber atrophy (HP:0003554)	3.07297786
19	Molar tooth sign on MRI (HP:0002419)	3.04680245
20	Abnormality of midbrain morphology (HP:0002418)	3.04680245
21	Increased hepatocellular lipid droplets (HP:0006565)	3.01064939
22	Decreased central vision (HP:0007663)	3.00451964
23	Hepatic necrosis (HP:0002605)	2.99175030
24	Optic disc pallor (HP:0000543)	2.86399320
25	Reticulocytopenia (HP:0001896)	2.80134376
26	True hermaphroditism (HP:0010459)	2.78512862
27	Chronic hepatic failure (HP:0100626)	2.78221277
28	Cerebral edema (HP:0002181)	2.76876586
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.75280723
30	3-Methylglutaconic aciduria (HP:0003535)	2.74704509
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.72769409
32	Abolished electroretinogram (ERG) (HP:0000550)	2.72626486
33	Pendular nystagmus (HP:0012043)	2.72061464
34	Methylmalonic acidemia (HP:0002912)	2.67949267
35	Increased serum lactate (HP:0002151)	2.61010940
36	Constricted visual fields (HP:0001133)	2.55224910
37	Muscle fiber atrophy (HP:0100295)	2.53411625
38	Hyperglycinemia (HP:0002154)	2.51658607
39	Nephronophthisis (HP:0000090)	2.49147753
40	Increased intramyocellular lipid droplets (HP:0012240)	2.48609906
41	Lactic acidosis (HP:0003128)	2.46442257
42	Methylmalonic aciduria (HP:0012120)	2.44093475
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.41570744
44	Type II lissencephaly (HP:0007260)	2.41127927
45	Increased muscle lipid content (HP:0009058)	2.39981252
46	Asplenia (HP:0001746)	2.37808980
47	Renal Fanconi syndrome (HP:0001994)	2.36853157
48	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.30020766
49	Keratoconus (HP:0000563)	2.27074005
50	Increased corneal curvature (HP:0100692)	2.27074005
51	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.24942128
52	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.24942128
53	Aplasia/hypoplasia of the uterus (HP:0008684)	2.21052817
54	Absent/shortened dynein arms (HP:0200106)	2.20241743
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20241743
56	Macrocytic anemia (HP:0001972)	2.19564236
57	Abnormality of the renal cortex (HP:0011035)	2.19206589
58	Lethargy (HP:0001254)	2.17641602
59	Stomatitis (HP:0010280)	2.16337309
60	Cystic liver disease (HP:0006706)	2.14797777
61	Abnormality of the renal medulla (HP:0100957)	2.11267128
62	Severe combined immunodeficiency (HP:0004430)	2.10394766
63	Colon cancer (HP:0003003)	2.08507666
64	Respiratory failure (HP:0002878)	2.05053654
65	Pallor (HP:0000980)	2.04480455
66	Hypoplasia of the uterus (HP:0000013)	2.02841360
67	Ketosis (HP:0001946)	2.01398209
68	Abnormality of macular pigmentation (HP:0008002)	2.01250465
69	Cerebral palsy (HP:0100021)	1.99826039
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98483263
71	Panhypogammaglobulinemia (HP:0003139)	1.98107187
72	Medial flaring of the eyebrow (HP:0010747)	1.97108092
73	Absent thumb (HP:0009777)	1.94266332
74	Abnormal drinking behavior (HP:0030082)	1.92513461
75	Polydipsia (HP:0001959)	1.92513461
76	Hypomagnesemia (HP:0002917)	1.91296194
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.88627410
78	Abnormality of alanine metabolism (HP:0010916)	1.88627410
79	Hyperalaninemia (HP:0003348)	1.88627410
80	Abnormality of the prostate (HP:0008775)	1.88255399
81	Exertional dyspnea (HP:0002875)	1.87023526
82	Agitation (HP:0000713)	1.86823551
83	Renal cortical cysts (HP:0000803)	1.83556767
84	Sclerocornea (HP:0000647)	1.82728680
85	Dicarboxylic aciduria (HP:0003215)	1.81902069
86	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.81902069
87	Abnormal biliary tract physiology (HP:0012439)	1.81776188
88	Bile duct proliferation (HP:0001408)	1.81776188
89	Abnormal respiratory epithelium morphology (HP:0012253)	1.81745806
90	Abnormal respiratory motile cilium morphology (HP:0005938)	1.81745806
91	Progressive inability to walk (HP:0002505)	1.80915155
92	Abnormality of urine glucose concentration (HP:0011016)	1.80230669
93	Glycosuria (HP:0003076)	1.80230669
94	Polyuria (HP:0000103)	1.77926301
95	Abnormality of the pons (HP:0007361)	1.75408881
96	Thyroiditis (HP:0100646)	1.73708183
97	Abnormality of T cells (HP:0002843)	1.72810938
98	Leukodystrophy (HP:0002415)	1.69239705
99	Anencephaly (HP:0002323)	1.68991126
100	Abnormality of T cell physiology (HP:0011840)	1.68780908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.54371240
2	TLK1	3.51582423
3	TXK	3.39984711
4	ZAK	3.21001033
5	ADRBK2	2.80856429
6	TAOK3	2.64611401
7	GRK1	2.48752351
8	KIT	2.43711140
9	FRK	2.30475076
10	WNK4	2.18552055
11	TESK2	2.18438246
12	PASK	2.14308474
13	TIE1	2.07359373
14	NUAK1	2.02959395
15	MAP4K1	2.00689121
16	FES	1.94600540
17	MAP4K2	1.87296109
18	IKBKB	1.81228524
19	TEC	1.68398578
20	WNK3	1.40054225
21	IKBKE	1.38766307
22	MAP2K2	1.38737915
23	BMPR1B	1.37690268
24	VRK2	1.36522969
25	PINK1	1.35140335
26	MAPKAPK3	1.31005322
27	STK16	1.29377853
28	DYRK2	1.25429075
29	PHKG1	1.25021311
30	PHKG2	1.25021311
31	CDK19	1.24583503
32	KDR	1.21861908
33	CSNK1G3	1.20068631
34	SYK	1.19533390
35	GRK6	1.14724237
36	ITK	1.14536267
37	CAMKK1	1.09995943
38	INSRR	1.09829678
39	CAMKK2	1.06113697
40	MAP3K14	1.05167904
41	PRKCQ	1.04028566
42	ADRBK1	1.00844499
43	TBK1	0.98244548
44	OXSR1	0.95637398
45	RPS6KA5	0.94131842
46	CSNK1G2	0.93918094
47	PIK3CA	0.92669922
48	CSNK1G1	0.90262232
49	MUSK	0.89630311
50	CSNK1A1L	0.83454946
51	STK39	0.80148941
52	MAP3K13	0.80077993
53	BTK	0.79514307
54	LCK	0.79156207
55	CSF1R	0.77991608
56	MAP2K6	0.75701970
57	MST4	0.72442513
58	JAK3	0.72309980
59	NME2	0.71914788
60	VRK1	0.71106520
61	LYN	0.65371396
62	MAPK13	0.63628810
63	ACVR1B	0.61936742
64	PDK2	0.61844239
65	CHUK	0.61610162
66	DAPK2	0.59866464
67	NEK1	0.57369162
68	LRRK2	0.56823565
69	EIF2AK3	0.53652897
70	MKNK1	0.53421661
71	SIK2	0.53278890
72	PIM1	0.51750969
73	OBSCN	0.50085803
74	PRKACA	0.49424194
75	GRK7	0.48712153
76	PRKCG	0.48573713
77	PRKCI	0.48011252
78	EIF2AK2	0.47715170
79	SRPK1	0.46223618
80	TGFBR1	0.45902163
81	PRKCA	0.44875130
82	GRK5	0.44020071
83	DAPK1	0.43321104
84	CDC7	0.42907649
85	ABL2	0.40298564
86	CSNK2A2	0.39398799
87	MAPKAPK5	0.38686029
88	STK11	0.38577035
89	LIMK1	0.38565110
90	CSNK1D	0.38245098
91	MAP3K11	0.37993556
92	MAP3K4	0.37091124
93	CSNK2A1	0.36694265
94	CSNK1A1	0.36639768
95	IGF1R	0.35702953
96	ABL1	0.35469848
97	PIM2	0.34029157
98	PLK3	0.32462391
99	RPS6KA6	0.31618577
100	PLK1	0.30909414

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.14789158
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.07600660
3	Asthma_Homo sapiens_hsa05310	3.06464195
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.88633558
5	Allograft rejection_Homo sapiens_hsa05330	2.77385858
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.64849697
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.51341697
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44256730
9	Parkinsons disease_Homo sapiens_hsa05012	2.43283904
10	Proteasome_Homo sapiens_hsa03050	2.41440339
11	Caffeine metabolism_Homo sapiens_hsa00232	2.24727905
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.19694332
13	RNA polymerase_Homo sapiens_hsa03020	2.09860285
14	Phototransduction_Homo sapiens_hsa04744	2.04134245
15	Primary immunodeficiency_Homo sapiens_hsa05340	1.96899004
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88845105
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.73960290
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.68954941
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59518270
20	Alzheimers disease_Homo sapiens_hsa05010	1.53208139
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.50902112
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.50141682
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48964577
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.48603500
25	Huntingtons disease_Homo sapiens_hsa05016	1.47249276
26	Protein export_Homo sapiens_hsa03060	1.45309154
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.41002241
28	Homologous recombination_Homo sapiens_hsa03440	1.38386270
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.35179313
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.35052565
31	One carbon pool by folate_Homo sapiens_hsa00670	1.34058429
32	Rheumatoid arthritis_Homo sapiens_hsa05323	1.28965555
33	RNA degradation_Homo sapiens_hsa03018	1.28526966
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.21567980
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.18610211
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.18493947
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.17761113
38	Peroxisome_Homo sapiens_hsa04146	1.15383056
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06061884
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.05445482
41	Sulfur relay system_Homo sapiens_hsa04122	1.04821586
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.03892596
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.00209737
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99972821
45	Fanconi anemia pathway_Homo sapiens_hsa03460	0.97962966
46	Propanoate metabolism_Homo sapiens_hsa00640	0.96956427
47	Sulfur metabolism_Homo sapiens_hsa00920	0.95086431
48	Olfactory transduction_Homo sapiens_hsa04740	0.93786564
49	Purine metabolism_Homo sapiens_hsa00230	0.88850878
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86055612
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.83589876
52	Viral myocarditis_Homo sapiens_hsa05416	0.83448560
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83156503
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.82939887
55	Retinol metabolism_Homo sapiens_hsa00830	0.81549504
56	Mismatch repair_Homo sapiens_hsa03430	0.80927330
57	Butanoate metabolism_Homo sapiens_hsa00650	0.79151397
58	Fat digestion and absorption_Homo sapiens_hsa04975	0.78749161
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76670361
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74395867
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74034427
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.73541923
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72598768
64	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72596438
65	Base excision repair_Homo sapiens_hsa03410	0.68061245
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.65297758
67	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.65146561
68	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.65141228
69	Metabolic pathways_Homo sapiens_hsa01100	0.64836016
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64481351
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63914693
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.63556160
73	Nicotine addiction_Homo sapiens_hsa05033	0.63325581
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63053798
75	Basal transcription factors_Homo sapiens_hsa03022	0.62778369
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.59835752
77	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58153979
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56219580
79	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54737338
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54308075
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.51468168
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51351588
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49701423
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46431905
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46401922
86	Leishmaniasis_Homo sapiens_hsa05140	0.45302772
87	DNA replication_Homo sapiens_hsa03030	0.44273121
88	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.41618957
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40858041
90	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.38175273
91	Morphine addiction_Homo sapiens_hsa05032	0.38104272
92	Fatty acid elongation_Homo sapiens_hsa00062	0.38019167
93	Taste transduction_Homo sapiens_hsa04742	0.37853142
94	RNA transport_Homo sapiens_hsa03013	0.36228631
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.34957624
96	Spliceosome_Homo sapiens_hsa03040	0.34787433
97	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.33863087
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33301444
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.31120581
100	ABC transporters_Homo sapiens_hsa02010	0.26479196

EEF1GP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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