ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of meiosis I (GO:0060631)	5.07258417
2	auditory receptor cell stereocilium organization (GO:0060088)	4.64530399
3	DNA deamination (GO:0045006)	4.55492873
4	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.18649634
5	pseudouridine synthesis (GO:0001522)	3.92408265
6	chaperone-mediated protein transport (GO:0072321)	3.90613656
7	peptidyl-histidine modification (GO:0018202)	3.86655322
8	termination of RNA polymerase III transcription (GO:0006386)	3.82771642
9	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.82771642
10	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.77518332
11	proteasome assembly (GO:0043248)	3.71684657
12	positive regulation of prostaglandin secretion (GO:0032308)	3.64352230
13	histone H2A ubiquitination (GO:0033522)	3.56785781
14	L-fucose catabolic process (GO:0042355)	3.56249493
15	fucose catabolic process (GO:0019317)	3.56249493
16	L-fucose metabolic process (GO:0042354)	3.56249493
17	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.53152738
18	protein neddylation (GO:0045116)	3.45997323
19	indolalkylamine catabolic process (GO:0046218)	3.41672906
20	tryptophan catabolic process (GO:0006569)	3.41672906
21	indole-containing compound catabolic process (GO:0042436)	3.41672906
22	tryptophan metabolic process (GO:0006568)	3.36825476
23	negative regulation of telomere maintenance (GO:0032205)	3.29809552
24	indolalkylamine metabolic process (GO:0006586)	3.24973375
25	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.24744412
26	kynurenine metabolic process (GO:0070189)	3.23875918
27	rRNA methylation (GO:0031167)	3.23638877
28	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.21057839
29	piRNA metabolic process (GO:0034587)	3.17370623
30	base-excision repair, AP site formation (GO:0006285)	3.17202807
31	regulation of helicase activity (GO:0051095)	3.16917737
32	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.15259367
33	rRNA modification (GO:0000154)	3.14330429
34	endoderm formation (GO:0001706)	3.13181873
35	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.12951078
36	ubiquinone biosynthetic process (GO:0006744)	3.09042075
37	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.08459502
38	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.05372266
39	branched-chain amino acid catabolic process (GO:0009083)	3.04050534
40	DNA double-strand break processing (GO:0000729)	3.03846751
41	positive regulation of defense response to virus by host (GO:0002230)	3.01113941
42	mitochondrial RNA metabolic process (GO:0000959)	2.96045445
43	regulation of prostaglandin secretion (GO:0032306)	2.95863332
44	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.93793600
45	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.93793600
46	protein prenylation (GO:0018342)	2.92409988
47	prenylation (GO:0097354)	2.92409988
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.90255427
49	rRNA catabolic process (GO:0016075)	2.89326263
50	photoreceptor cell maintenance (GO:0045494)	2.88086619
51	reciprocal DNA recombination (GO:0035825)	2.85876963
52	reciprocal meiotic recombination (GO:0007131)	2.85876963
53	histone H2A acetylation (GO:0043968)	2.84176708
54	inner ear receptor stereocilium organization (GO:0060122)	2.83881290
55	interferon-gamma production (GO:0032609)	2.83642427
56	muscle organ morphogenesis (GO:0048644)	2.83434305
57	positive regulation of T-helper 1 type immune response (GO:0002827)	2.81913153
58	reflex (GO:0060004)	2.80353204
59	response to pheromone (GO:0019236)	2.79062195
60	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.78277282
61	axoneme assembly (GO:0035082)	2.77426093
62	water-soluble vitamin biosynthetic process (GO:0042364)	2.77199994
63	DNA methylation involved in gamete generation (GO:0043046)	2.76576755
64	replication fork processing (GO:0031297)	2.75401090
65	organelle disassembly (GO:1903008)	2.75191939
66	regulation of histone phosphorylation (GO:0033127)	2.74809227
67	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.73483365
68	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.73483365
69	NADH dehydrogenase complex assembly (GO:0010257)	2.73483365
70	transcription from RNA polymerase III promoter (GO:0006383)	2.73303875
71	protein-cofactor linkage (GO:0018065)	2.71273333
72	ubiquinone metabolic process (GO:0006743)	2.69610833
73	aggressive behavior (GO:0002118)	2.69421964
74	ncRNA 3-end processing (GO:0043628)	2.67023616
75	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.66020434
76	regulation of mitotic spindle checkpoint (GO:1903504)	2.66020434
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.65018002
78	resolution of meiotic recombination intermediates (GO:0000712)	2.64467471
79	inositol phosphate catabolic process (GO:0071545)	2.62092026
80	intra-S DNA damage checkpoint (GO:0031573)	2.61944559
81	tRNA processing (GO:0008033)	2.61790065
82	iron-sulfur cluster assembly (GO:0016226)	2.61711902
83	metallo-sulfur cluster assembly (GO:0031163)	2.61711902
84	protein targeting to mitochondrion (GO:0006626)	2.60235707
85	branched-chain amino acid metabolic process (GO:0009081)	2.59400272
86	cellular response to interferon-beta (GO:0035458)	2.58603192
87	nonmotile primary cilium assembly (GO:0035058)	2.57072949
88	behavioral response to nicotine (GO:0035095)	2.56293453
89	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.51881340
90	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.51316003
91	inositol phosphate dephosphorylation (GO:0046855)	2.51316003
92	termination of RNA polymerase I transcription (GO:0006363)	2.50527472
93	ribosomal small subunit assembly (GO:0000028)	2.49884970
94	S-adenosylmethionine metabolic process (GO:0046500)	2.48795362
95	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.48517549
96	protein complex biogenesis (GO:0070271)	2.47329002
97	positive regulation of fatty acid transport (GO:2000193)	2.46768026
98	quinone biosynthetic process (GO:1901663)	2.46172552
99	tRNA metabolic process (GO:0006399)	2.45787259
100	pyrimidine nucleotide catabolic process (GO:0006244)	2.45225182

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.36202368
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.77313126
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.68945086
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.63796627
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.61727691
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.41968072
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.12960277
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.10928122
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.95305535
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.82044669
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.69406205
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42455960
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.41317217
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39898473
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.37179662
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.30714424
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.27205788
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.22595074
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.20243622
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15130379
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.14514307
22	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.10230589
23	EWS_26573619_Chip-Seq_HEK293_Human	2.09049558
24	VDR_22108803_ChIP-Seq_LS180_Human	2.06650765
25	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.00211484
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.95099774
27	FUS_26573619_Chip-Seq_HEK293_Human	1.94861120
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87901142
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.76605224
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75225219
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73063492
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.70751931
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.69096082
34	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.65320533
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63101637
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60996813
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.59713371
38	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.59269540
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.58036306
40	CIITA_25753668_ChIP-Seq_RAJI_Human	1.56654667
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50048597
42	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.46062870
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46048392
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.42593541
45	DCP1A_22483619_ChIP-Seq_HELA_Human	1.39815417
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.38941502
47	P300_19829295_ChIP-Seq_ESCs_Human	1.38168483
48	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.33014911
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.30999369
50	AR_20517297_ChIP-Seq_VCAP_Human	1.29578467
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29145536
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.26571003
53	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.25841450
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.25620971
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.24160825
56	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.23059986
57	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.22480934
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20346432
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20272435
60	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.20050274
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.18160718
62	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.17724738
63	GATA3_26560356_Chip-Seq_TH2_Human	1.14787957
64	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.13095489
65	TTF2_22483619_ChIP-Seq_HELA_Human	1.10807187
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.09547659
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09547659
68	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.08163709
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04252748
70	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.02993874
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02457917
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02115002
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02115002
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00184884
75	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99432819
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99427265
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98265827
78	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98186820
79	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97654510
80	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97654510
81	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97637062
82	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.96633567
83	NCOR_22424771_ChIP-Seq_293T_Human	0.95669859
84	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95322493
85	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.94824826
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94644076
87	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.93473417
88	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93043776
89	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92277648
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92024342
91	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.91751970
92	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.90353820
93	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89223693
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.89162548
95	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.88951192
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.88357545
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.88296141
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88176536
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.87414284
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87374065

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.72237444
2	MP0001986_abnormal_taste_sensitivity	3.55813644
3	MP0005167_abnormal_blood-brain_barrier	3.23541578
4	MP0008877_abnormal_DNA_methylation	3.15475373
5	MP0008058_abnormal_DNA_repair	3.05188435
6	MP0002736_abnormal_nociception_after	2.96132940
7	MP0003941_abnormal_skin_development	2.94543055
8	MP0002138_abnormal_hepatobiliary_system	2.91137384
9	MP0005084_abnormal_gallbladder_morpholo	2.72283160
10	MP0003786_premature_aging	2.66779183
11	MP0004147_increased_porphyrin_level	2.64442863
12	MP0008995_early_reproductive_senescence	2.57347722
13	MP0001968_abnormal_touch/_nociception	2.39478560
14	MP0003724_increased_susceptibility_to	2.22507557
15	MP0008872_abnormal_physiological_respon	2.18591651
16	MP0006072_abnormal_retinal_apoptosis	2.16782432
17	MP0003718_maternal_effect	2.15216775
18	MP0002102_abnormal_ear_morphology	2.01153974
19	MP0000372_irregular_coat_pigmentation	1.92883415
20	MP0009697_abnormal_copulation	1.90864758
21	MP0008875_abnormal_xenobiotic_pharmacok	1.83958648
22	MP0003195_calcinosis	1.68565815
23	MP0002277_abnormal_respiratory_mucosa	1.67446190
24	MP0005646_abnormal_pituitary_gland	1.60096309
25	MP0005075_abnormal_melanosome_morpholog	1.57334135
26	MP0005551_abnormal_eye_electrophysiolog	1.56023832
27	MP0002234_abnormal_pharynx_morphology	1.48201624
28	MP0008775_abnormal_heart_ventricle	1.48060090
29	MP0001486_abnormal_startle_reflex	1.43312783
30	MP0006276_abnormal_autonomic_nervous	1.42160032
31	MP0005253_abnormal_eye_physiology	1.41281623
32	MP0003787_abnormal_imprinting	1.35016553
33	MP0002938_white_spotting	1.32052538
34	MP0003693_abnormal_embryo_hatching	1.31861676
35	MP0005410_abnormal_fertilization	1.20672942
36	MP0006035_abnormal_mitochondrial_morpho	1.18586040
37	MP0002396_abnormal_hematopoietic_system	1.17465009
38	MP0006036_abnormal_mitochondrial_physio	1.16806746
39	MP0010094_abnormal_chromosome_stability	1.16115752
40	MP0001929_abnormal_gametogenesis	1.16091484
41	MP0002006_tumorigenesis	1.13358593
42	MP0008057_abnormal_DNA_replication	1.12499093
43	MP0002751_abnormal_autonomic_nervous	1.08911126
44	MP0008873_increased_physiological_sensi	1.08561409
45	MP0004215_abnormal_myocardial_fiber	1.07568979
46	MP0003111_abnormal_nucleus_morphology	1.02461201
47	MP0004742_abnormal_vestibular_system	1.01878913
48	MP0005085_abnormal_gallbladder_physiolo	1.01473957
49	MP0001905_abnormal_dopamine_level	1.00307281
50	MP0009278_abnormal_bone_marrow	0.97121416
51	MP0001188_hyperpigmentation	0.95595629
52	MP0005671_abnormal_response_to	0.94513654
53	MP0001293_anophthalmia	0.93527611
54	MP0000467_abnormal_esophagus_morphology	0.92890737
55	MP0003186_abnormal_redox_activity	0.92725626
56	MP0001919_abnormal_reproductive_system	0.92696912
57	MP0004885_abnormal_endolymph	0.92123383
58	MP0003698_abnormal_male_reproductive	0.91067824
59	MP0005395_other_phenotype	0.90713815
60	MP0003011_delayed_dark_adaptation	0.90109052
61	MP0001501_abnormal_sleep_pattern	0.90008092
62	MP0009764_decreased_sensitivity_to	0.89536963
63	MP0005174_abnormal_tail_pigmentation	0.88501457
64	MP0003880_abnormal_central_pattern	0.88101889
65	MP0000230_abnormal_systemic_arterial	0.87145707
66	MP0003136_yellow_coat_color	0.86628777
67	MP0004957_abnormal_blastocyst_morpholog	0.85874071
68	MP0003252_abnormal_bile_duct	0.84725483
69	MP0002210_abnormal_sex_determination	0.84695644
70	MP0000631_abnormal_neuroendocrine_gland	0.84566447
71	MP0001835_abnormal_antigen_presentation	0.83059707
72	MP0002837_dystrophic_cardiac_calcinosis	0.82352604
73	MP0003646_muscle_fatigue	0.82235564
74	MP0002876_abnormal_thyroid_physiology	0.82197013
75	MP0001145_abnormal_male_reproductive	0.79510140
76	MP0002638_abnormal_pupillary_reflex	0.77979570
77	MP0002733_abnormal_thermal_nociception	0.76143409
78	MP0002272_abnormal_nervous_system	0.75643347
79	MP0004142_abnormal_muscle_tone	0.74857045
80	MP0000653_abnormal_sex_gland	0.74655449
81	MP0003137_abnormal_impulse_conducting	0.74554851
82	MP0001485_abnormal_pinna_reflex	0.74416219
83	MP0002139_abnormal_hepatobiliary_system	0.74308252
84	MP0004145_abnormal_muscle_electrophysio	0.73336544
85	MP0000613_abnormal_salivary_gland	0.69559655
86	MP0001800_abnormal_humoral_immune	0.68500440
87	MP0005451_abnormal_body_composition	0.67853765
88	MP0002723_abnormal_immune_serum	0.67244487
89	MP0000013_abnormal_adipose_tissue	0.67013885
90	MP0003119_abnormal_digestive_system	0.66979274
91	MP0000465_gastrointestinal_hemorrhage	0.66840230
92	MP0003077_abnormal_cell_cycle	0.66515132
93	MP0002067_abnormal_sensory_capabilities	0.66392778
94	MP0002019_abnormal_tumor_incidence	0.65208022
95	MP0000689_abnormal_spleen_morphology	0.64754992
96	MP0005423_abnormal_somatic_nervous	0.63252082
97	MP0003567_abnormal_fetal_cardiomyocyte	0.62572135
98	MP0001963_abnormal_hearing_physiology	0.62440922
99	MP0005389_reproductive_system_phenotype	0.62130689
100	MP0001542_abnormal_bone_strength	0.62023101

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.81520766
2	Molar tooth sign on MRI (HP:0002419)	3.49733780
3	Abnormality of midbrain morphology (HP:0002418)	3.49733780
4	Pancreatic cysts (HP:0001737)	3.45692313
5	Abolished electroretinogram (ERG) (HP:0000550)	3.31810194
6	Stomach cancer (HP:0012126)	3.18935633
7	Renal cortical cysts (HP:0000803)	3.11340236
8	IgG deficiency (HP:0004315)	3.06749970
9	Panhypogammaglobulinemia (HP:0003139)	3.03464475
10	Abnormality of the renal cortex (HP:0011035)	3.03395767
11	Nephronophthisis (HP:0000090)	2.99142633
12	Congenital sensorineural hearing impairment (HP:0008527)	2.94324269
13	Pancreatic fibrosis (HP:0100732)	2.94088105
14	Colon cancer (HP:0003003)	2.92787585
15	Elevated erythrocyte sedimentation rate (HP:0003565)	2.77231524
16	Methylmalonic acidemia (HP:0002912)	2.76006730
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.73591861
18	Increased CSF lactate (HP:0002490)	2.72391582
19	True hermaphroditism (HP:0010459)	2.72055886
20	Attenuation of retinal blood vessels (HP:0007843)	2.67902870
21	Abnormality of the renal medulla (HP:0100957)	2.63750475
22	Type II lissencephaly (HP:0007260)	2.62714250
23	3-Methylglutaconic aciduria (HP:0003535)	2.61896373
24	Constricted visual fields (HP:0001133)	2.61694751
25	Severe combined immunodeficiency (HP:0004430)	2.60631361
26	Acute necrotizing encephalopathy (HP:0006965)	2.53826950
27	Mitochondrial inheritance (HP:0001427)	2.50292481
28	Hepatocellular necrosis (HP:0001404)	2.48354763
29	Abnormality of alanine metabolism (HP:0010916)	2.43569531
30	Hyperalaninemia (HP:0003348)	2.43569531
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.43569531
32	Increased hepatocellular lipid droplets (HP:0006565)	2.40498572
33	Medial flaring of the eyebrow (HP:0010747)	2.33604672
34	Progressive microcephaly (HP:0000253)	2.33470277
35	Prostate neoplasm (HP:0100787)	2.33195731
36	Lipid accumulation in hepatocytes (HP:0006561)	2.30857568
37	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.28021256
38	Meckel diverticulum (HP:0002245)	2.26789911
39	Hepatic necrosis (HP:0002605)	2.26252345
40	Increased serum lactate (HP:0002151)	2.26136066
41	Abnormality of eosinophils (HP:0001879)	2.22776987
42	Retinal dysplasia (HP:0007973)	2.22482642
43	Pendular nystagmus (HP:0012043)	2.21945523
44	Abnormality of the ileum (HP:0001549)	2.20631562
45	Abnormal mitochondria in muscle tissue (HP:0008316)	2.20357202
46	Acute encephalopathy (HP:0006846)	2.20133080
47	Clubbing of toes (HP:0100760)	2.19965389
48	Abnormal biliary tract physiology (HP:0012439)	2.19907816
49	Bile duct proliferation (HP:0001408)	2.19907816
50	Eosinophilia (HP:0001880)	2.19623356
51	Methylmalonic aciduria (HP:0012120)	2.18716422
52	Abnormality of the anterior horn cell (HP:0006802)	2.16185153
53	Degeneration of anterior horn cells (HP:0002398)	2.16185153
54	Progressive macrocephaly (HP:0004481)	2.15847879
55	Abnormality of B cell number (HP:0010975)	2.14775305
56	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08384835
57	Abnormality of T cell physiology (HP:0011840)	2.04217243
58	Type 2 muscle fiber atrophy (HP:0003554)	2.02076024
59	Thyroiditis (HP:0100646)	2.01053619
60	Abnormality of T cell number (HP:0011839)	2.00530087
61	Congenital hepatic fibrosis (HP:0002612)	1.99764445
62	Neoplasm of the adrenal cortex (HP:0100641)	1.98827253
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98117303
64	Abnormal rod and cone electroretinograms (HP:0008323)	1.96785181
65	T lymphocytopenia (HP:0005403)	1.96398810
66	Lactic acidosis (HP:0003128)	1.95928148
67	Congenital stationary night blindness (HP:0007642)	1.95732308
68	Short tibia (HP:0005736)	1.93739657
69	Hypoplasia of the pons (HP:0012110)	1.93522785
70	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93295465
71	Abnormality of the preputium (HP:0100587)	1.92686500
72	Cerebral edema (HP:0002181)	1.92100034
73	Supernumerary spleens (HP:0009799)	1.89844100
74	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.89282439
75	Entropion (HP:0000621)	1.87599079
76	Abnormality of the pons (HP:0007361)	1.87279411
77	Hypochromic microcytic anemia (HP:0004840)	1.86959287
78	Optic disc pallor (HP:0000543)	1.86657891
79	Polydipsia (HP:0001959)	1.86400262
80	Abnormal drinking behavior (HP:0030082)	1.86400262
81	Combined immunodeficiency (HP:0005387)	1.86175292
82	Abnormality of T cells (HP:0002843)	1.85605522
83	Abnormality of chromosome stability (HP:0003220)	1.85212663
84	Conical tooth (HP:0000698)	1.84354521
85	Polyuria (HP:0000103)	1.83969478
86	Congenital, generalized hypertrichosis (HP:0004540)	1.83003240
87	Abnormal spermatogenesis (HP:0008669)	1.82733681
88	Lethargy (HP:0001254)	1.82291605
89	Submucous cleft hard palate (HP:0000176)	1.82085439
90	Cystic liver disease (HP:0006706)	1.81990622
91	Azoospermia (HP:0000027)	1.81743347
92	Hypoproteinemia (HP:0003075)	1.81473146
93	Hyperglycinuria (HP:0003108)	1.81299181
94	Duplicated collecting system (HP:0000081)	1.81026572
95	Sclerocornea (HP:0000647)	1.80936707
96	Delayed CNS myelination (HP:0002188)	1.79235217
97	Absent thumb (HP:0009777)	1.78913080
98	Nephrogenic diabetes insipidus (HP:0009806)	1.77241174
99	Abnormality of the renal collecting system (HP:0004742)	1.77093085
100	Abnormal glycosylation (HP:0012345)	1.75792863

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	5.13777848
2	STK16	3.47029738
3	ZAK	3.42040325
4	MAP4K2	3.07605583
5	TIE1	3.01099043
6	BCKDK	2.95215134
7	BMPR1B	2.81318754
8	TAOK3	2.54438958
9	VRK2	2.47857058
10	TLK1	2.28192322
11	EIF2AK3	2.27009474
12	TXK	2.26942982
13	SRPK1	2.24911074
14	ACVR1B	2.18321548
15	CDK19	1.77932440
16	GRK1	1.71783988
17	VRK1	1.65661829
18	BUB1	1.62881188
19	FRK	1.60847895
20	MAPK13	1.41644693
21	NEK1	1.40702836
22	CSNK1G3	1.38787419
23	ADRBK2	1.37188808
24	MKNK1	1.32530981
25	PINK1	1.29646420
26	TRIM28	1.28742875
27	TSSK6	1.25552864
28	CSNK1G1	1.25013094
29	TGFBR1	1.20098858
30	BCR	1.19750583
31	PLK3	1.18342583
32	CSNK1A1L	1.17678940
33	EPHA3	1.15325718
34	TEC	1.10274673
35	CSNK1G2	1.06565061
36	RPS6KB2	1.05745713
37	WNK3	1.03589837
38	WNK4	0.97530601
39	TAF1	0.96491145
40	KIT	0.93399659
41	AKT3	0.90393688
42	RPS6KA4	0.85874734
43	SIK3	0.84728823
44	FLT3	0.83300035
45	RAF1	0.80185277
46	DYRK3	0.79700780
47	MKNK2	0.78703337
48	IKBKB	0.78690496
49	TTK	0.77977306
50	OXSR1	0.77439699
51	PLK4	0.76097833
52	EIF2AK2	0.75944133
53	RPS6KA5	0.73540785
54	PRKD3	0.72120927
55	DYRK2	0.71856162
56	MAP2K7	0.71611163
57	PTK2B	0.66900654
58	PLK2	0.66168479
59	TNIK	0.63213738
60	STK39	0.63184920
61	EIF2AK1	0.61271297
62	MAP2K2	0.60470512
63	PAK3	0.60061150
64	ERBB3	0.59503119
65	DAPK1	0.59293880
66	MAP3K4	0.58088860
67	MAPKAPK5	0.56049286
68	MST4	0.55025587
69	TBK1	0.54338643
70	PDK2	0.53666182
71	ATR	0.50450604
72	GRK5	0.50069888
73	SCYL2	0.49259937
74	PRKCQ	0.48761546
75	CCNB1	0.48173780
76	DMPK	0.47241944
77	MATK	0.47143115
78	GRK6	0.46826295
79	INSRR	0.46678264
80	PASK	0.45540511
81	PIM2	0.44029007
82	FER	0.42736046
83	PHKG1	0.42267397
84	PHKG2	0.42267397
85	IKBKE	0.40819656
86	IRAK1	0.38585831
87	EPHA4	0.38409402
88	FES	0.37922440
89	PRKCE	0.34611393
90	MAP3K14	0.34075334
91	MAPKAPK3	0.33911899
92	CSNK1A1	0.32084635
93	SYK	0.31805454
94	ATM	0.31762024
95	CSNK1D	0.31578716
96	RPS6KB1	0.29973396
97	ERBB4	0.29895289
98	PIM1	0.29670869
99	BTK	0.27305013
100	MET	0.26864098

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.20088002
2	RNA polymerase_Homo sapiens_hsa03020	2.91809881
3	Selenocompound metabolism_Homo sapiens_hsa00450	2.39103943
4	Proteasome_Homo sapiens_hsa03050	2.22860923
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.19140347
6	Basal transcription factors_Homo sapiens_hsa03022	2.18696131
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.18687026
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.07705045
9	Homologous recombination_Homo sapiens_hsa03440	2.07517833
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02263815
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.02003646
12	Base excision repair_Homo sapiens_hsa03410	1.99791657
13	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.98105934
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94019537
15	Protein export_Homo sapiens_hsa03060	1.91230333
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.88417825
17	Butanoate metabolism_Homo sapiens_hsa00650	1.83033813
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.81235791
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.80050863
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.74687180
21	Propanoate metabolism_Homo sapiens_hsa00640	1.70948685
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.67153466
23	RNA degradation_Homo sapiens_hsa03018	1.64852554
24	One carbon pool by folate_Homo sapiens_hsa00670	1.63588837
25	Spliceosome_Homo sapiens_hsa03040	1.63571032
26	Ribosome_Homo sapiens_hsa03010	1.62816696
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.58168641
28	RNA transport_Homo sapiens_hsa03013	1.53198964
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.52660475
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.49887210
31	Parkinsons disease_Homo sapiens_hsa05012	1.49275941
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.47014550
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45353750
34	Asthma_Homo sapiens_hsa05310	1.45037447
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42045073
36	Allograft rejection_Homo sapiens_hsa05330	1.40348754
37	Purine metabolism_Homo sapiens_hsa00230	1.30596664
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.29516944
39	Fatty acid elongation_Homo sapiens_hsa00062	1.26843151
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25659637
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.25045302
42	Peroxisome_Homo sapiens_hsa04146	1.23614900
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.19669940
44	Caffeine metabolism_Homo sapiens_hsa00232	1.18574122
45	Nucleotide excision repair_Homo sapiens_hsa03420	1.17687869
46	Mismatch repair_Homo sapiens_hsa03430	1.16314858
47	DNA replication_Homo sapiens_hsa03030	1.15881985
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.14259517
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12862862
50	Antigen processing and presentation_Homo sapiens_hsa04612	1.11678884
51	Phototransduction_Homo sapiens_hsa04744	1.09643442
52	Nitrogen metabolism_Homo sapiens_hsa00910	1.08529728
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06227918
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.00266994
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.98847888
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.93948123
57	Type I diabetes mellitus_Homo sapiens_hsa04940	0.93184010
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.90673208
59	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.86728573
60	Fatty acid metabolism_Homo sapiens_hsa01212	0.86516519
61	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.83801617
62	Huntingtons disease_Homo sapiens_hsa05016	0.83734173
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82986270
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80966424
65	Regulation of autophagy_Homo sapiens_hsa04140	0.80255417
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.78237350
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77897338
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73356956
69	ABC transporters_Homo sapiens_hsa02010	0.73046391
70	Fatty acid degradation_Homo sapiens_hsa00071	0.69449765
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.65897238
72	Metabolic pathways_Homo sapiens_hsa01100	0.63424536
73	Olfactory transduction_Homo sapiens_hsa04740	0.62765831
74	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.61706177
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61281179
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58873375
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58561260
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55333881
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54178713
80	Retinol metabolism_Homo sapiens_hsa00830	0.53464894
81	Herpes simplex infection_Homo sapiens_hsa05168	0.52823631
82	Sulfur metabolism_Homo sapiens_hsa00920	0.52738754
83	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51678999
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.51443629
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46845378
86	Ether lipid metabolism_Homo sapiens_hsa00565	0.46401605
87	Alzheimers disease_Homo sapiens_hsa05010	0.46166154
88	Taste transduction_Homo sapiens_hsa04742	0.44534619
89	p53 signaling pathway_Homo sapiens_hsa04115	0.43657464
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.41265710
91	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39018185
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38376118
93	Circadian rhythm_Homo sapiens_hsa04710	0.38355831
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36715907
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33004487
96	Glutathione metabolism_Homo sapiens_hsa00480	0.31701993
97	Nicotine addiction_Homo sapiens_hsa05033	0.30686594
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28614339
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.27831313
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.25789913

EEF1GP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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