ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.03514096
2	rRNA modification (GO:0000154)	4.36028418
3	ribosomal small subunit assembly (GO:0000028)	4.28945467
4	water-soluble vitamin biosynthetic process (GO:0042364)	3.93524624
5	rRNA methylation (GO:0031167)	3.72335840
6	ATP synthesis coupled proton transport (GO:0015986)	3.67720991
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.67720991
8	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.40839840
9	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.40839840
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.40708967
11	L-fucose catabolic process (GO:0042355)	3.40059329
12	fucose catabolic process (GO:0019317)	3.40059329
13	L-fucose metabolic process (GO:0042354)	3.40059329
14	proteasome assembly (GO:0043248)	3.39988394
15	piRNA metabolic process (GO:0034587)	3.38670575
16	platelet dense granule organization (GO:0060155)	3.38267554
17	positive regulation of prostaglandin secretion (GO:0032308)	3.37760835
18	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.27709858
19	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.24900994
20	aggressive behavior (GO:0002118)	3.21238041
21	tryptophan metabolic process (GO:0006568)	3.14970710
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.09989795
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.09989795
24	NADH dehydrogenase complex assembly (GO:0010257)	3.09989795
25	behavioral response to nicotine (GO:0035095)	3.09914137
26	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00181231
27	ubiquinone biosynthetic process (GO:0006744)	2.98272682
28	indolalkylamine metabolic process (GO:0006586)	2.97483354
29	chaperone-mediated protein transport (GO:0072321)	2.96514489
30	amino acid salvage (GO:0043102)	2.94730502
31	L-methionine salvage (GO:0071267)	2.94730502
32	L-methionine biosynthetic process (GO:0071265)	2.94730502
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.94278049
34	protein-cofactor linkage (GO:0018065)	2.91413135
35	protein deneddylation (GO:0000338)	2.90195123
36	cellular response to interferon-beta (GO:0035458)	2.89623210
37	cellular response to exogenous dsRNA (GO:0071360)	2.86153533
38	rRNA catabolic process (GO:0016075)	2.84407388
39	protein complex biogenesis (GO:0070271)	2.81804622
40	cullin deneddylation (GO:0010388)	2.80842795
41	S-adenosylmethionine metabolic process (GO:0046500)	2.80687021
42	indole-containing compound catabolic process (GO:0042436)	2.80337064
43	indolalkylamine catabolic process (GO:0046218)	2.80337064
44	tryptophan catabolic process (GO:0006569)	2.80337064
45	regulation of mitotic spindle checkpoint (GO:1903504)	2.80263054
46	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.80263054
47	peptidyl-histidine modification (GO:0018202)	2.80049787
48	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.79443422
49	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.79302859
50	pseudouridine synthesis (GO:0001522)	2.78447273
51	protein polyglutamylation (GO:0018095)	2.78128806
52	kynurenine metabolic process (GO:0070189)	2.77361012
53	cytidine metabolic process (GO:0046087)	2.76712582
54	cytidine catabolic process (GO:0006216)	2.76712582
55	cytidine deamination (GO:0009972)	2.76712582
56	preassembly of GPI anchor in ER membrane (GO:0016254)	2.72828691
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71986666
58	GTP biosynthetic process (GO:0006183)	2.71655435
59	tRNA processing (GO:0008033)	2.70945762
60	positive regulation of fatty acid transport (GO:2000193)	2.70894513
61	mannosylation (GO:0097502)	2.70610494
62	branched-chain amino acid catabolic process (GO:0009083)	2.69532409
63	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.68509386
64	termination of RNA polymerase III transcription (GO:0006386)	2.68509386
65	DNA methylation involved in gamete generation (GO:0043046)	2.64643261
66	negative regulation of telomere maintenance (GO:0032205)	2.63818758
67	purine deoxyribonucleotide catabolic process (GO:0009155)	2.63785208
68	electron transport chain (GO:0022900)	2.63316162
69	positive regulation of defense response to virus by host (GO:0002230)	2.62877709
70	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.61679039
71	respiratory electron transport chain (GO:0022904)	2.58353077
72	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.56674353
73	termination of RNA polymerase I transcription (GO:0006363)	2.55808801
74	ubiquinone metabolic process (GO:0006743)	2.55700122
75	regulation of prostaglandin secretion (GO:0032306)	2.53509277
76	male meiosis (GO:0007140)	2.51466498
77	cellular response to dsRNA (GO:0071359)	2.51301011
78	resolution of meiotic recombination intermediates (GO:0000712)	2.50837618
79	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.50481000
80	synapsis (GO:0007129)	2.50241482
81	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.50115180
82	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.49943696
83	quinone biosynthetic process (GO:1901663)	2.49882154
84	positive regulation of icosanoid secretion (GO:0032305)	2.49694826
85	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.49665805
86	replication fork processing (GO:0031297)	2.49509430
87	response to interferon-beta (GO:0035456)	2.49197288
88	ribosomal large subunit biogenesis (GO:0042273)	2.46192798
89	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.43691828
90	inositol phosphate dephosphorylation (GO:0046855)	2.42842713
91	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.42842713
92	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.41715138
93	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.41715138
94	isotype switching (GO:0045190)	2.41715138
95	tRNA modification (GO:0006400)	2.41594574
96	GPI anchor biosynthetic process (GO:0006506)	2.39788221
97	regulation of penile erection (GO:0060405)	2.38673989
98	regulation of cellular amino acid metabolic process (GO:0006521)	2.38604163
99	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.38360310
100	protein neddylation (GO:0045116)	2.38220759

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.91028303
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.90743462
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.60047082
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.02069560
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.01479627
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.90699384
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.87891948
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.87243904
9	VDR_22108803_ChIP-Seq_LS180_Human	2.85905409
10	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.73227328
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.59826330
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.48867616
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.47339537
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.42676142
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.30389652
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.23425820
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.19032083
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15130200
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.04407759
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.02654906
21	MYC_18940864_ChIP-ChIP_HL60_Human	2.01935006
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.92734688
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89982487
24	EWS_26573619_Chip-Seq_HEK293_Human	1.85176203
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84648211
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.82449140
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74696095
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70957232
29	FUS_26573619_Chip-Seq_HEK293_Human	1.68105449
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.67067602
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.61551266
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.59514430
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.58587045
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.58587045
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.58170783
36	AR_20517297_ChIP-Seq_VCAP_Human	1.58036502
37	EZH2_22144423_ChIP-Seq_EOC_Human	1.55906376
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.47388577
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.41368405
40	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38433462
41	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.36356414
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.34353248
43	GATA3_26560356_Chip-Seq_TH2_Human	1.32980265
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.32608370
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.31769806
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.31769806
47	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31282461
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.28910047
49	IRF1_19129219_ChIP-ChIP_H3396_Human	1.27986531
50	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.27769000
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26174745
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26028569
53	ERG_20517297_ChIP-Seq_VCAP_Human	1.25464842
54	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.25178265
55	ER_23166858_ChIP-Seq_MCF-7_Human	1.23924008
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.21481821
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.20908597
58	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19978000
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.19771013
60	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.19628261
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19306174
62	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18607837
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18468957
64	CBP_20019798_ChIP-Seq_JUKART_Human	1.16508084
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.16508084
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15822574
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15630405
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14161870
69	NCOR_22424771_ChIP-Seq_293T_Human	1.12385034
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12296281
71	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11545097
72	CIITA_25753668_ChIP-Seq_RAJI_Human	1.10872383
73	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10618074
74	P300_19829295_ChIP-Seq_ESCs_Human	1.10073432
75	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08663676
76	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.08327375
77	ERA_21632823_ChIP-Seq_H3396_Human	1.07727676
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.07450284
79	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.06790678
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.06586632
81	TTF2_22483619_ChIP-Seq_HELA_Human	1.05796409
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05478436
83	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.05173551
84	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.03733704
85	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03566721
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01895009
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01788061
88	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99637017
89	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.98850091
90	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97889557
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.97638489
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.96559367
93	DCP1A_22483619_ChIP-Seq_HELA_Human	0.96432440
94	GABP_19822575_ChIP-Seq_HepG2_Human	0.95509891
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93635524
96	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.91944454
97	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91889509
98	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.90836104
99	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.90281001
100	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90221577

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002138_abnormal_hepatobiliary_system	3.40644042
2	MP0006292_abnormal_olfactory_placode	3.37212554
3	MP0004147_increased_porphyrin_level	3.37007678
4	MP0003011_delayed_dark_adaptation	3.01722515
5	MP0000569_abnormal_digit_pigmentation	2.93110450
6	MP0008875_abnormal_xenobiotic_pharmacok	2.91735232
7	MP0003718_maternal_effect	2.81065747
8	MP0005671_abnormal_response_to	2.50098196
9	MP0005084_abnormal_gallbladder_morpholo	2.32839596
10	MP0008872_abnormal_physiological_respon	2.32310582
11	MP0008877_abnormal_DNA_methylation	2.25292164
12	MP0005646_abnormal_pituitary_gland	2.21355578
13	MP0008058_abnormal_DNA_repair	2.09147136
14	MP0006072_abnormal_retinal_apoptosis	2.07273348
15	MP0005075_abnormal_melanosome_morpholog	2.07061077
16	MP0001986_abnormal_taste_sensitivity	2.05454357
17	MP0003646_muscle_fatigue	1.95091568
18	MP0005551_abnormal_eye_electrophysiolog	1.84226661
19	MP0002102_abnormal_ear_morphology	1.80950652
20	MP0001293_anophthalmia	1.77276357
21	MP0001835_abnormal_antigen_presentation	1.75512509
22	MP0005174_abnormal_tail_pigmentation	1.74501796
23	MP0004885_abnormal_endolymph	1.73678728
24	MP0002876_abnormal_thyroid_physiology	1.73641700
25	MP0005085_abnormal_gallbladder_physiolo	1.71195597
26	MP0002837_dystrophic_cardiac_calcinosis	1.61941026
27	MP0001968_abnormal_touch/_nociception	1.56105803
28	MP0000372_irregular_coat_pigmentation	1.55921583
29	MP0006036_abnormal_mitochondrial_physio	1.55150207
30	MP0006276_abnormal_autonomic_nervous	1.54363713
31	MP0002139_abnormal_hepatobiliary_system	1.54014012
32	MP0001800_abnormal_humoral_immune	1.52337246
33	MP0005253_abnormal_eye_physiology	1.48854183
34	MP0004145_abnormal_muscle_electrophysio	1.46077557
35	MP0002234_abnormal_pharynx_morphology	1.45244397
36	MP0002148_abnormal_hypersensitivity_rea	1.44779158
37	MP0003724_increased_susceptibility_to	1.42626778
38	MP0002095_abnormal_skin_pigmentation	1.42284291
39	MP0002277_abnormal_respiratory_mucosa	1.38972359
40	MP0005360_urolithiasis	1.37484649
41	MP0003252_abnormal_bile_duct	1.37332889
42	MP0003806_abnormal_nucleotide_metabolis	1.36073204
43	MP0002736_abnormal_nociception_after	1.33231977
44	MP0005410_abnormal_fertilization	1.30800822
45	MP0001764_abnormal_homeostasis	1.29103415
46	MP0000685_abnormal_immune_system	1.26489167
47	MP0005167_abnormal_blood-brain_barrier	1.21670492
48	MP0010094_abnormal_chromosome_stability	1.18980502
49	MP0005645_abnormal_hypothalamus_physiol	1.18700278
50	MP0002928_abnormal_bile_duct	1.17544936
51	MP0005387_immune_system_phenotype	1.16859025
52	MP0001790_abnormal_immune_system	1.16859025
53	MP0001905_abnormal_dopamine_level	1.16727766
54	MP0002938_white_spotting	1.14600581
55	MP0000013_abnormal_adipose_tissue	1.13575810
56	MP0003195_calcinosis	1.11667844
57	MP0000015_abnormal_ear_pigmentation	1.06861220
58	MP0002723_abnormal_immune_serum	1.05284692
59	MP0005000_abnormal_immune_tolerance	1.03653681
60	MP0003786_premature_aging	1.03451135
61	MP0005377_hearing/vestibular/ear_phenot	1.02761474
62	MP0003878_abnormal_ear_physiology	1.02761474
63	MP0002160_abnormal_reproductive_system	1.02592285
64	MP0005389_reproductive_system_phenotype	1.02489776
65	MP0001929_abnormal_gametogenesis	1.02333797
66	MP0002272_abnormal_nervous_system	1.02281210
67	MP0002452_abnormal_antigen_presenting	1.02088391
68	MP0000230_abnormal_systemic_arterial	0.98373748
69	MP0009697_abnormal_copulation	0.96856648
70	MP0003693_abnormal_embryo_hatching	0.96778180
71	MP0009764_decreased_sensitivity_to	0.96652182
72	MP0008789_abnormal_olfactory_epithelium	0.96612819
73	MP0005365_abnormal_bile_salt	0.95233551
74	MP0009379_abnormal_foot_pigmentation	0.93543306
75	MP0003787_abnormal_imprinting	0.93539020
76	MP0006035_abnormal_mitochondrial_morpho	0.92557203
77	MP0005636_abnormal_mineral_homeostasis	0.91725122
78	MP0008775_abnormal_heart_ventricle	0.86292384
79	MP0001501_abnormal_sleep_pattern	0.86045888
80	MP0002420_abnormal_adaptive_immunity	0.85068381
81	MP0001819_abnormal_immune_cell	0.84902524
82	MP0000427_abnormal_hair_cycle	0.82085867
83	MP0002006_tumorigenesis	0.81816266
84	MP0005332_abnormal_amino_acid	0.81199543
85	MP0009046_muscle_twitch	0.80397059
86	MP0001666_abnormal_nutrient_absorption	0.80045754
87	MP0001765_abnormal_ion_homeostasis	0.78500930
88	MP0003638_abnormal_response/metabolism_	0.76758894
89	MP0001663_abnormal_digestive_system	0.75976697
90	MP0004019_abnormal_vitamin_homeostasis	0.75714119
91	MP0003880_abnormal_central_pattern	0.75440310
92	MP0003567_abnormal_fetal_cardiomyocyte	0.74377387
93	MP0003186_abnormal_redox_activity	0.73633175
94	MP0001348_abnormal_lacrimal_gland	0.73185299
95	MP0005391_vision/eye_phenotype	0.71822227
96	MP0001664_abnormal_digestion	0.71050860
97	MP0000653_abnormal_sex_gland	0.70311796
98	MP0000631_abnormal_neuroendocrine_gland	0.69955146
99	MP0010329_abnormal_lipoprotein_level	0.69022335
100	MP0005395_other_phenotype	0.68940665

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.63269538
2	Abnormality of midbrain morphology (HP:0002418)	3.49037903
3	Molar tooth sign on MRI (HP:0002419)	3.49037903
4	Pancreatic fibrosis (HP:0100732)	3.35621363
5	Acute necrotizing encephalopathy (HP:0006965)	3.33569445
6	Congenital stationary night blindness (HP:0007642)	3.30244820
7	Type 2 muscle fiber atrophy (HP:0003554)	3.23886410
8	Nephronophthisis (HP:0000090)	3.20309937
9	Acute encephalopathy (HP:0006846)	3.13795526
10	IgG deficiency (HP:0004315)	3.10847604
11	Reduced antithrombin III activity (HP:0001976)	3.09679274
12	3-Methylglutaconic aciduria (HP:0003535)	3.01915592
13	Mitochondrial inheritance (HP:0001427)	3.01001530
14	Attenuation of retinal blood vessels (HP:0007843)	2.99265868
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.97612285
16	Increased CSF lactate (HP:0002490)	2.89346361
17	Hepatic necrosis (HP:0002605)	2.83284883
18	Abnormality of the renal medulla (HP:0100957)	2.79966766
19	Abolished electroretinogram (ERG) (HP:0000550)	2.78837149
20	Progressive macrocephaly (HP:0004481)	2.77820699
21	Abnormal biliary tract physiology (HP:0012439)	2.76976020
22	Bile duct proliferation (HP:0001408)	2.76976020
23	Stomatitis (HP:0010280)	2.76125311
24	Abnormality of the renal cortex (HP:0011035)	2.76049338
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.73665457
26	True hermaphroditism (HP:0010459)	2.71412424
27	Decreased central vision (HP:0007663)	2.69336666
28	Hepatocellular necrosis (HP:0001404)	2.69036862
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.67317009
30	Type I transferrin isoform profile (HP:0003642)	2.66785747
31	Hyperglycinemia (HP:0002154)	2.65379715
32	Muscle fiber atrophy (HP:0100295)	2.62420380
33	Methylmalonic acidemia (HP:0002912)	2.57100453
34	Abnormality of alanine metabolism (HP:0010916)	2.52866455
35	Hyperalaninemia (HP:0003348)	2.52866455
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.52866455
37	Supernumerary spleens (HP:0009799)	2.49973440
38	Increased serum lactate (HP:0002151)	2.45485053
39	Cerebral edema (HP:0002181)	2.43610583
40	Colon cancer (HP:0003003)	2.35862767
41	Panhypogammaglobulinemia (HP:0003139)	2.33089841
42	Abnormality of B cell number (HP:0010975)	2.31635338
43	Abnormality of the pons (HP:0007361)	2.30840996
44	Medial flaring of the eyebrow (HP:0010747)	2.26231709
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.25670866
46	Renal cortical cysts (HP:0000803)	2.24782492
47	Lactic acidosis (HP:0003128)	2.24124439
48	Optic disc pallor (HP:0000543)	2.23061278
49	Hypoplasia of the pons (HP:0012110)	2.20953434
50	Ketosis (HP:0001946)	2.20502284
51	Lethargy (HP:0001254)	2.19743823
52	Increased hepatocellular lipid droplets (HP:0006565)	2.19684948
53	Abnormal number of erythroid precursors (HP:0012131)	2.18332247
54	Methylmalonic aciduria (HP:0012120)	2.17953944
55	Type II lissencephaly (HP:0007260)	2.14056549
56	Lipid accumulation in hepatocytes (HP:0006561)	2.13964617
57	Agammaglobulinemia (HP:0004432)	2.12181141
58	Cystic liver disease (HP:0006706)	2.11054723
59	Abnormality of serum amino acid levels (HP:0003112)	2.10770681
60	Abnormal protein glycosylation (HP:0012346)	2.10105699
61	Abnormal glycosylation (HP:0012345)	2.10105699
62	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.10105699
63	Abnormal protein N-linked glycosylation (HP:0012347)	2.10105699
64	Posterior subcapsular cataract (HP:0007787)	2.08940345
65	Abnormality of serine family amino acid metabolism (HP:0010894)	2.08152980
66	Abnormality of glycine metabolism (HP:0010895)	2.08152980
67	Pendular nystagmus (HP:0012043)	2.07630093
68	Hypoproteinemia (HP:0003075)	2.05804766
69	Keratoconus (HP:0000563)	2.04591597
70	Increased corneal curvature (HP:0100692)	2.04591597
71	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.03348814
72	Chronic hepatic failure (HP:0100626)	2.02232707
73	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.01736531
74	Dicarboxylic aciduria (HP:0003215)	2.01736531
75	IgM deficiency (HP:0002850)	2.01635596
76	Thrombocytosis (HP:0001894)	2.01277323
77	Hyperglycinuria (HP:0003108)	1.99510982
78	B lymphocytopenia (HP:0010976)	1.99198747
79	Congenital hepatic fibrosis (HP:0002612)	1.99115582
80	Abnormality of cells of the erythroid lineage (HP:0012130)	1.98208569
81	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.97478455
82	Asplenia (HP:0001746)	1.96872078
83	Pancytopenia (HP:0001876)	1.96320776
84	Generalized aminoaciduria (HP:0002909)	1.94795806
85	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.94576433
86	Polydipsia (HP:0001959)	1.94500123
87	Abnormal drinking behavior (HP:0030082)	1.94500123
88	Abnormality of the prostate (HP:0008775)	1.93996608
89	Aplasia/hypoplasia of the uterus (HP:0008684)	1.93744486
90	Chronic sinusitis (HP:0011109)	1.91231546
91	Abnormal rod and cone electroretinograms (HP:0008323)	1.88318950
92	Progressive microcephaly (HP:0000253)	1.84249753
93	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.83947326
94	Tubular atrophy (HP:0000092)	1.83476091
95	Opisthotonus (HP:0002179)	1.81738789
96	Congenital sensorineural hearing impairment (HP:0008527)	1.78567321
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78094498
98	Abnormality of T cell physiology (HP:0011840)	1.78015769
99	Abnormality of urine glucose concentration (HP:0011016)	1.77199257
100	Glycosuria (HP:0003076)	1.77199257

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.15117169
2	ZAK	3.70899361
3	TAOK3	3.49268328
4	TIE1	3.37556114
5	TESK2	3.36729148
6	GRK1	3.25706103
7	NUAK1	2.83303619
8	VRK2	2.76040299
9	TLK1	2.63725720
10	INSRR	2.58280267
11	BCKDK	2.36875785
12	TXK	2.36096256
13	ADRBK2	2.23594542
14	STK16	2.13150778
15	KIT	2.09122538
16	FRK	1.93462097
17	VRK1	1.76751333
18	CDK19	1.58353171
19	MAPKAPK3	1.51702884
20	MST4	1.49154475
21	MUSK	1.41930220
22	TEC	1.36387025
23	MKNK1	1.35230476
24	CCNB1	1.30329277
25	OXSR1	1.26891597
26	ITK	1.26490947
27	PINK1	1.23384631
28	WNK4	1.22783047
29	PASK	1.19657226
30	EIF2AK3	1.09768502
31	CSNK1G3	1.09198445
32	TSSK6	1.04314319
33	CSNK1G1	1.03799850
34	RPS6KA5	1.03258797
35	PIK3CG	1.02150734
36	IKBKB	1.01957760
37	MAPKAPK5	1.01949356
38	TAF1	1.01265604
39	MAP3K13	1.00194891
40	FES	0.98886997
41	MATK	0.97558550
42	SYK	0.96837388
43	BMPR1B	0.93384415
44	PBK	0.91980017
45	SRPK1	0.90600346
46	BUB1	0.90514896
47	PHKG2	0.89633142
48	PHKG1	0.89633142
49	STK39	0.86395089
50	JAK3	0.83286616
51	PLK3	0.82680117
52	CSNK1A1L	0.81321731
53	ACVR1B	0.80932902
54	WNK3	0.79797001
55	IKBKE	0.77100266
56	CSNK1G2	0.76833669
57	DAPK1	0.76012489
58	PRKCQ	0.73338860
59	DYRK2	0.70863447
60	TBK1	0.66593884
61	GRK6	0.65779253
62	MAPK13	0.63597753
63	KDR	0.62704811
64	BTK	0.62407849
65	EIF2AK1	0.61425718
66	TRIM28	0.60960354
67	RIPK4	0.59521182
68	MAP4K1	0.59055720
69	MAP2K7	0.59010693
70	PLK4	0.54642328
71	TNK2	0.54407121
72	ATR	0.51810520
73	LCK	0.51579957
74	TGFBR1	0.51116832
75	PLK2	0.50650402
76	EIF2AK2	0.48488679
77	LYN	0.47113972
78	AURKB	0.46960911
79	MAP2K2	0.46249734
80	ADRBK1	0.43814317
81	IRAK1	0.40348559
82	CAMKK2	0.39309594
83	MAP2K6	0.38127014
84	GRK5	0.38052616
85	NEK1	0.36634602
86	CDK8	0.36558207
87	IGF1R	0.35206098
88	NME1	0.35146884
89	DAPK2	0.33843522
90	CSNK2A1	0.33517376
91	PRKCE	0.33240318
92	MAPK11	0.32171116
93	MAPK7	0.28750818
94	PRKCA	0.27261175
95	ALK	0.27000162
96	ATM	0.26756235
97	CSNK2A2	0.26164708
98	PRKCI	0.26028293
99	PRKACA	0.24752520
100	PRKCG	0.23285066

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	3.35358156
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.04228660
3	Proteasome_Homo sapiens_hsa03050	2.75978721
4	Allograft rejection_Homo sapiens_hsa05330	2.71604025
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.56396319
6	Ribosome_Homo sapiens_hsa03010	2.43638065
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.23832392
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.05810749
9	RNA polymerase_Homo sapiens_hsa03020	2.04160289
10	Graft-versus-host disease_Homo sapiens_hsa05332	1.96447423
11	One carbon pool by folate_Homo sapiens_hsa00670	1.90121256
12	Linoleic acid metabolism_Homo sapiens_hsa00591	1.89319269
13	Parkinsons disease_Homo sapiens_hsa05012	1.89094485
14	Type I diabetes mellitus_Homo sapiens_hsa04940	1.87972709
15	Homologous recombination_Homo sapiens_hsa03440	1.85141394
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.80049375
17	Protein export_Homo sapiens_hsa03060	1.79520080
18	Propanoate metabolism_Homo sapiens_hsa00640	1.76353155
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73084211
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.66044542
21	Phototransduction_Homo sapiens_hsa04744	1.65674422
22	Mismatch repair_Homo sapiens_hsa03430	1.60038207
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52132529
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.42560806
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42374932
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.42192531
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41295837
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.40461196
29	RNA degradation_Homo sapiens_hsa03018	1.40107503
30	Basal transcription factors_Homo sapiens_hsa03022	1.38665687
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.37055342
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.36340575
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35415848
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32900122
35	Caffeine metabolism_Homo sapiens_hsa00232	1.32702848
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29241574
37	Purine metabolism_Homo sapiens_hsa00230	1.23074021
38	Nucleotide excision repair_Homo sapiens_hsa03420	1.18093746
39	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.17423210
40	Butanoate metabolism_Homo sapiens_hsa00650	1.17045529
41	Peroxisome_Homo sapiens_hsa04146	1.12537240
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.12504958
43	Nitrogen metabolism_Homo sapiens_hsa00910	1.12174977
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10996625
45	Sulfur metabolism_Homo sapiens_hsa00920	1.07995065
46	DNA replication_Homo sapiens_hsa03030	1.06564216
47	Huntingtons disease_Homo sapiens_hsa05016	1.02608380
48	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02154120
49	Fat digestion and absorption_Homo sapiens_hsa04975	1.00440200
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00112747
51	Rheumatoid arthritis_Homo sapiens_hsa05323	0.98679508
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98298672
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96046976
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.93897219
55	Alzheimers disease_Homo sapiens_hsa05010	0.93479553
56	RNA transport_Homo sapiens_hsa03013	0.92636282
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.89421584
58	Retinol metabolism_Homo sapiens_hsa00830	0.87111603
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86830632
60	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86034425
61	Olfactory transduction_Homo sapiens_hsa04740	0.85955246
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.85651817
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.84868755
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84856539
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84569636
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83824769
67	Base excision repair_Homo sapiens_hsa03410	0.83359285
68	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82049579
69	Ether lipid metabolism_Homo sapiens_hsa00565	0.81647373
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80722918
71	Spliceosome_Homo sapiens_hsa03040	0.80427854
72	Selenocompound metabolism_Homo sapiens_hsa00450	0.78743430
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.76732653
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.74276440
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71812896
76	Metabolic pathways_Homo sapiens_hsa01100	0.67413447
77	Fatty acid elongation_Homo sapiens_hsa00062	0.67397500
78	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65877411
79	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65307017
80	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.64325858
81	Glutathione metabolism_Homo sapiens_hsa00480	0.62489982
82	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61539513
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57185418
84	ABC transporters_Homo sapiens_hsa02010	0.55554917
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.55205394
86	Fatty acid degradation_Homo sapiens_hsa00071	0.54748898
87	Regulation of autophagy_Homo sapiens_hsa04140	0.53190600
88	Viral myocarditis_Homo sapiens_hsa05416	0.49687996
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.47653174
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46983878
91	Taste transduction_Homo sapiens_hsa04742	0.46293183
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46080270
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44389079
94	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.43701365
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42782719
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41953557
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.40979597
98	Arginine biosynthesis_Homo sapiens_hsa00220	0.40448324
99	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.30846693
100	Salivary secretion_Homo sapiens_hsa04970	0.30552739

EEF1GP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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