EEFSEC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.35281328
2ribosomal small subunit assembly (GO:0000028)4.55255706
3DNA strand elongation involved in DNA replication (GO:0006271)4.42294924
4DNA strand elongation (GO:0022616)4.27718366
5telomere maintenance via semi-conservative replication (GO:0032201)4.18649267
6folic acid-containing compound biosynthetic process (GO:0009396)4.07409357
7NADH metabolic process (GO:0006734)4.00415451
8proline biosynthetic process (GO:0006561)3.97685079
9DNA replication initiation (GO:0006270)3.91248598
10DNA unwinding involved in DNA replication (GO:0006268)3.85307062
11Golgi transport vesicle coating (GO:0048200)3.82932563
12COPI coating of Golgi vesicle (GO:0048205)3.82932563
13maturation of SSU-rRNA (GO:0030490)3.79623636
14glycine metabolic process (GO:0006544)3.77808370
15peptidyl-arginine omega-N-methylation (GO:0035247)3.76208574
16negative regulation of cell size (GO:0045792)3.72711230
17viral transcription (GO:0019083)3.67866645
18nucleobase biosynthetic process (GO:0046112)3.67068927
19pentose-phosphate shunt (GO:0006098)3.64330929
20translational termination (GO:0006415)3.61050423
21negative regulation of erythrocyte differentiation (GO:0045647)3.60025401
22telomere maintenance via recombination (GO:0000722)3.58692826
23serine family amino acid biosynthetic process (GO:0009070)3.51747633
243-UTR-mediated mRNA stabilization (GO:0070935)3.51602115
25pinocytosis (GO:0006907)3.49179750
26protein maturation by protein folding (GO:0022417)3.48310105
27purine nucleobase biosynthetic process (GO:0009113)3.47057633
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41747719
29regulation of mammary gland epithelial cell proliferation (GO:0033599)3.37215829
30* translational elongation (GO:0006414)3.37161123
31regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.34992055
32pteridine-containing compound biosynthetic process (GO:0042559)3.32276324
33mitotic recombination (GO:0006312)3.30389667
34formation of translation preinitiation complex (GO:0001731)3.29398514
35tetrahydrofolate metabolic process (GO:0046653)3.28995741
36folic acid metabolic process (GO:0046655)3.27651263
37L-serine metabolic process (GO:0006563)3.27341839
38GDP-mannose metabolic process (GO:0019673)3.27155234
39telomere maintenance via telomere lengthening (GO:0010833)3.24242243
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22028471
41histone arginine methylation (GO:0034969)3.20565958
42proteasome assembly (GO:0043248)3.20334698
43pentose metabolic process (GO:0019321)3.18541716
44NADPH regeneration (GO:0006740)3.16949737
45DNA replication checkpoint (GO:0000076)3.16139611
46glucose catabolic process (GO:0006007)3.14790690
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13262653
48ribosomal large subunit biogenesis (GO:0042273)3.12693705
49cotranslational protein targeting to membrane (GO:0006613)3.11346816
50IMP biosynthetic process (GO:0006188)3.11048479
51protein targeting to ER (GO:0045047)3.09636380
52L-phenylalanine metabolic process (GO:0006558)3.05848916
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.05848916
54tricarboxylic acid metabolic process (GO:0072350)3.04672745
55pseudouridine synthesis (GO:0001522)3.04462526
56ribosomal small subunit biogenesis (GO:0042274)3.03070885
57translational initiation (GO:0006413)3.02907832
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.01327851
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.99757840
60somatic hypermutation of immunoglobulin genes (GO:0016446)2.98139838
61somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98139838
62protein localization to endoplasmic reticulum (GO:0070972)2.96727091
63pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.94931906
64ribonucleoprotein complex biogenesis (GO:0022613)2.93535653
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.93338259
66oxaloacetate metabolic process (GO:0006107)2.91457959
67ribosome biogenesis (GO:0042254)2.91247562
68serine family amino acid metabolic process (GO:0009069)2.91185810
69CENP-A containing nucleosome assembly (GO:0034080)2.90825239
70establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90008992
71proline metabolic process (GO:0006560)2.89906870
72chromatin remodeling at centromere (GO:0031055)2.89835148
73cellular response to interleukin-4 (GO:0071353)2.89456859
74one-carbon metabolic process (GO:0006730)2.88170321
75DNA replication-dependent nucleosome assembly (GO:0006335)2.88042759
76DNA replication-dependent nucleosome organization (GO:0034723)2.88042759
77mitotic nuclear envelope disassembly (GO:0007077)2.87763972
78pyrimidine-containing compound salvage (GO:0008655)2.86967104
79pyrimidine nucleoside salvage (GO:0043097)2.86967104
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.86414268
81L-phenylalanine catabolic process (GO:0006559)2.86414268
82protein retention in ER lumen (GO:0006621)2.84827743
83peptidyl-arginine methylation (GO:0018216)2.84212815
84peptidyl-arginine N-methylation (GO:0035246)2.84212815
85folic acid-containing compound metabolic process (GO:0006760)2.83194912
86nucleotide salvage (GO:0043173)2.82461189
87pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.82213079
88viral life cycle (GO:0019058)2.81052466
89spliceosomal snRNP assembly (GO:0000387)2.80147233
90UV protection (GO:0009650)2.78653412
91negative regulation of B cell apoptotic process (GO:0002903)2.77873024
92cellular hyperosmotic response (GO:0071474)2.77122553
93cellular protein complex disassembly (GO:0043624)2.76947653
94IMP metabolic process (GO:0046040)2.76788869
95maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76470450
96spliceosomal tri-snRNP complex assembly (GO:0000244)2.75965967
97modulation by virus of host process (GO:0019054)2.75300173
98apoptotic process involved in morphogenesis (GO:0060561)2.73178670
99regulation of mitochondrial translation (GO:0070129)2.72215080
100protein localization to kinetochore (GO:0034501)2.71977532
101regulation of superoxide anion generation (GO:0032928)2.70708570
102nucleoside salvage (GO:0043174)2.69002928
103negative regulation of DNA-templated transcription, elongation (GO:0032785)2.68369215
104DNA duplex unwinding (GO:0032508)2.68191076
105rRNA processing (GO:0006364)2.67806282
106urea cycle (GO:0000050)2.67448309
107pteridine-containing compound metabolic process (GO:0042558)2.67308079
108DNA geometric change (GO:0032392)2.66987547
109regulation of translational fidelity (GO:0006450)2.66619262
110glucose 6-phosphate metabolic process (GO:0051156)2.66435600
111telomere organization (GO:0032200)2.66319073
112telomere maintenance (GO:0000723)2.65736344
113monosaccharide biosynthetic process (GO:0046364)2.64644465
114neutrophil activation involved in immune response (GO:0002283)2.64479127
115mitochondrial fusion (GO:0008053)2.61189998
116rRNA metabolic process (GO:0016072)2.60313355
117nuclear envelope disassembly (GO:0051081)2.59980787
118membrane disassembly (GO:0030397)2.59980787
119antigen processing and presentation of endogenous antigen (GO:0019883)2.59727242
120translation (GO:0006412)2.59549845
121negative regulation of necroptotic process (GO:0060546)2.59322379
122chaperone mediated protein folding requiring cofactor (GO:0051085)2.58805333
123pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.58386774
124UMP metabolic process (GO:0046049)2.58386774
125pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.58386774
126UMP biosynthetic process (GO:0006222)2.58386774
127protein localization to chromosome, centromeric region (GO:0071459)2.58090308
128aromatic amino acid family catabolic process (GO:0009074)2.56779046
129positive thymic T cell selection (GO:0045059)2.56601901
130response to peptidoglycan (GO:0032494)2.56081245
131DNA replication-independent nucleosome assembly (GO:0006336)2.55054854
132DNA replication-independent nucleosome organization (GO:0034724)2.55054854
133negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.55041231
134glyoxylate metabolic process (GO:0046487)2.54423181
135protein complex disassembly (GO:0043241)2.54307447
136snRNA metabolic process (GO:0016073)2.54011783
137ribosome assembly (GO:0042255)2.53688819
138deoxyribose phosphate biosynthetic process (GO:0046385)2.52511518
1392-deoxyribonucleotide biosynthetic process (GO:0009265)2.52511518
140negative regulation of myeloid cell apoptotic process (GO:0033033)2.52216686
141iron-sulfur cluster assembly (GO:0016226)2.52041817
142metallo-sulfur cluster assembly (GO:0031163)2.52041817
143serine family amino acid catabolic process (GO:0009071)2.51336362
144metaphase plate congression (GO:0051310)2.50167090
145negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50150905
146mismatch repair (GO:0006298)2.49988417
147transcription-coupled nucleotide-excision repair (GO:0006283)2.49421608
1482-oxoglutarate metabolic process (GO:0006103)2.49361511
149urea metabolic process (GO:0019627)2.48426867
150regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48386212
151nitrogen cycle metabolic process (GO:0071941)2.47483854
152modulation by symbiont of host defense response (GO:0052031)2.47121123
153modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47121123
154modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47121123
155positive regulation by organism of defense response of other organism involved in symbiotic interact2.47121123
156modulation by symbiont of host immune response (GO:0052553)2.47121123
157positive regulation by symbiont of host defense response (GO:0052509)2.47121123
158gluconeogenesis (GO:0006094)2.45766931
159response to interleukin-4 (GO:0070670)2.45486175
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45379369
161amino acid salvage (GO:0043102)2.44767681
162L-methionine salvage (GO:0071267)2.44767681
163L-methionine biosynthetic process (GO:0071265)2.44767681
164nuclear-transcribed mRNA catabolic process (GO:0000956)2.44749047
165establishment of integrated proviral latency (GO:0075713)2.44263506
166NIK/NF-kappaB signaling (GO:0038061)2.44070688
167anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43974611
168regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.43375709
169modulation by symbiont of host cellular process (GO:0044068)2.42197290
170regulation of defense response to virus by virus (GO:0050690)2.42100570
171macromolecular complex disassembly (GO:0032984)2.41052976
172histone exchange (GO:0043486)2.40610632
173negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.40559386
174virion assembly (GO:0019068)2.39620616
175regulation of monocyte differentiation (GO:0045655)2.37670283
176response to muramyl dipeptide (GO:0032495)2.37281012
177hexose biosynthetic process (GO:0019319)2.36392308
178positive regulation of gamma-delta T cell activation (GO:0046645)2.36381528
179protein insertion into membrane (GO:0051205)2.35789992
180protein-DNA complex disassembly (GO:0032986)2.35534366
181nucleosome disassembly (GO:0006337)2.35534366
182thymic T cell selection (GO:0045061)2.33834018
183activation of MAPKKK activity (GO:0000185)2.33766955
184poly(A)+ mRNA export from nucleus (GO:0016973)2.32571555
185antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.30148199
186dosage compensation (GO:0007549)2.28730998
187tricarboxylic acid cycle (GO:0006099)2.28109311
188intracellular estrogen receptor signaling pathway (GO:0030520)2.27714043
189ncRNA 3-end processing (GO:0043628)2.25766489
190positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.24542384
191rRNA transcription (GO:0009303)2.24520113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.08799869
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89441236
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.83336485
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.82396687
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79373394
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73286920
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71512901
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70032764
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66534835
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60050046
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.52890879
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52478695
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.47256869
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45258800
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45034250
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.43829353
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38315327
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32651882
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29022637
20LXR_22292898_ChIP-Seq_THP-1_Human2.27514444
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.17353067
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16435140
23XRN2_22483619_ChIP-Seq_HELA_Human2.15533932
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13480451
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06026130
26VDR_23849224_ChIP-Seq_CD4+_Human2.04948060
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04342316
28FOXP3_21729870_ChIP-Seq_TREG_Human1.95504396
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94336511
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.91687541
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.91053534
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90586509
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90569112
34MYC_22102868_ChIP-Seq_BL_Human1.89396664
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89243765
36* GABP_19822575_ChIP-Seq_HepG2_Human1.83223008
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82382083
38DCP1A_22483619_ChIP-Seq_HELA_Human1.80536500
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76139561
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75223356
41* AR_21909140_ChIP-Seq_LNCAP_Human1.73486099
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69741534
43ZNF263_19887448_ChIP-Seq_K562_Human1.66201418
44* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.64459081
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.64450379
46* TET1_21451524_ChIP-Seq_MESCs_Mouse1.63629026
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63386850
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.61602312
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61276040
50TCF7_22412390_ChIP-Seq_EML_Mouse1.59273717
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56147746
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55036128
53KDM2B_26808549_Chip-Seq_DND41_Human1.54669372
54RACK7_27058665_Chip-Seq_MCF-7_Human1.54652745
55P68_20966046_ChIP-Seq_HELA_Human1.54565963
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54441697
57KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54027291
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.53992493
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.53540828
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52694255
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50011925
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48414485
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47640421
64TTF2_22483619_ChIP-Seq_HELA_Human1.46829368
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.46698158
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46620813
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46254323
68VDR_24763502_ChIP-Seq_THP-1_Human1.45867762
69MAF_26560356_Chip-Seq_TH2_Human1.45305289
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43007778
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41722094
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40474096
73CIITA_25753668_ChIP-Seq_RAJI_Human1.40278534
74* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39181314
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36520149
76KDM5A_27292631_Chip-Seq_BREAST_Human1.35370583
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34893033
78VDR_21846776_ChIP-Seq_THP-1_Human1.34848385
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33519719
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.33215329
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.30992381
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30128178
83BCL6_27268052_Chip-Seq_Bcells_Human1.29506027
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28877407
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27812279
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26417544
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26389301
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26288770
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26176242
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.25997182
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25803257
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.25149704
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24112749
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24072642
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23754867
96BCOR_27268052_Chip-Seq_Bcells_Human1.23601096
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22431207
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22265726
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21782453
100SCL_19346495_ChIP-Seq_HPC-7_Human1.20653102
101SMC4_20622854_ChIP-Seq_HELA_Human1.20255704
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18673119
103EGR1_19374776_ChIP-ChIP_THP-1_Human1.18217545
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16645195
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16041310
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15966911
107BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14820163
108NCOR1_26117541_ChIP-Seq_K562_Human1.14784130
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14678675
110SPI1_23547873_ChIP-Seq_NB4_Human1.13850513
111SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12586735
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12404628
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11305641
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11236678
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.11050921
116ELK1_19687146_ChIP-ChIP_HELA_Human1.09033601
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08532114
118CTCF_21964334_Chip-Seq_Bcells_Human1.08456126
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08248101
120ETS1_21867929_ChIP-Seq_TH2_Mouse1.06283313
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06109906
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04705890
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04580413
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03689968
125HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02784734
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00492525
127RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00453538
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99374826
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98748030
130TFEB_21752829_ChIP-Seq_HELA_Human0.98691628
131MYC_18940864_ChIP-ChIP_HL60_Human0.97827765
132* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97397198
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96989944
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.95221150
135E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95199864
136UTX_26944678_Chip-Seq_JUKART_Human0.93389691
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91283447
138CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89005746
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87791060
140BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87217473
141CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86655018
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86229085
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85074892
144PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84609070
145MAF_26560356_Chip-Seq_TH1_Human0.84046480
146MYB_26560356_Chip-Seq_TH1_Human0.82391405

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.92169428
2MP0005451_abnormal_body_composition3.83619748
3MP0005360_urolithiasis3.79681402
4MP0003806_abnormal_nucleotide_metabolis3.75129022
5MP0003693_abnormal_embryo_hatching3.43247660
6MP0010094_abnormal_chromosome_stability3.29976977
7MP0005058_abnormal_lysosome_morphology3.25711212
8MP0008260_abnormal_autophagy3.07674264
9MP0004957_abnormal_blastocyst_morpholog3.04866850
10MP0005365_abnormal_bile_salt2.98973616
11MP0003111_abnormal_nucleus_morphology2.95624071
12MP0005085_abnormal_gallbladder_physiolo2.91681454
13MP0002396_abnormal_hematopoietic_system2.67252838
14MP0003077_abnormal_cell_cycle2.66129860
15MP0004233_abnormal_muscle_weight2.59376270
16MP0008058_abnormal_DNA_repair2.55956942
17MP0008875_abnormal_xenobiotic_pharmacok2.37565815
18MP0008007_abnormal_cellular_replicative2.11038279
19MP0003763_abnormal_thymus_physiology2.10921928
20MP0008057_abnormal_DNA_replication2.03738336
21MP0004858_abnormal_nervous_system1.99857139
22MP0009278_abnormal_bone_marrow1.91893696
23MP0000685_abnormal_immune_system1.88746128
24MP0009840_abnormal_foam_cell1.87102130
25MP0005075_abnormal_melanosome_morpholog1.84855822
26MP0000490_abnormal_crypts_of1.72617208
27MP0003303_peritoneal_inflammation1.70731153
28MP0003705_abnormal_hypodermis_morpholog1.67078897
29MP0003195_calcinosis1.66286687
30MP0003186_abnormal_redox_activity1.65451033
31MP0000858_altered_metastatic_potential1.63112705
32MP0001764_abnormal_homeostasis1.57650944
33MP0005670_abnormal_white_adipose1.56999335
34MP0000751_myopathy1.53948678
35MP0001730_embryonic_growth_arrest1.52759256
36MP0003252_abnormal_bile_duct1.52583105
37MP0005671_abnormal_response_to1.52377325
38MP0005076_abnormal_cell_differentiation1.49286638
39MP0006036_abnormal_mitochondrial_physio1.48087409
40MP0002419_abnormal_innate_immunity1.46526920
41MP0005000_abnormal_immune_tolerance1.44979629
42MP0010329_abnormal_lipoprotein_level1.44254810
43MP0004808_abnormal_hematopoietic_stem1.43721492
44MP0008932_abnormal_embryonic_tissue1.42729017
45MP0000689_abnormal_spleen_morphology1.41723530
46MP0002019_abnormal_tumor_incidence1.41470251
47MP0002722_abnormal_immune_system1.41172974
48MP0002398_abnormal_bone_marrow1.41125268
49MP0003786_premature_aging1.41054174
50MP0005464_abnormal_platelet_physiology1.38340001
51MP0002132_abnormal_respiratory_system1.37851135
52MP0003172_abnormal_lysosome_physiology1.37747685
53MP0001545_abnormal_hematopoietic_system1.37302273
54MP0005397_hematopoietic_system_phenotyp1.37302273
55MP0004185_abnormal_adipocyte_glucose1.37269195
56MP0003075_altered_response_to1.36282749
57MP0005332_abnormal_amino_acid1.35084467
58MP0000678_abnormal_parathyroid_gland1.34529214
59MP0010352_gastrointestinal_tract_polyps1.33362407
60MP0005666_abnormal_adipose_tissue1.32627009
61MP0000703_abnormal_thymus_morphology1.30022417
62MP0009333_abnormal_splenocyte_physiolog1.30013749
63MP0000609_abnormal_liver_physiology1.27690716
64MP0000747_muscle_weakness1.27175046
65MP0003656_abnormal_erythrocyte_physiolo1.25728500
66MP0003718_maternal_effect1.23813321
67MP0001835_abnormal_antigen_presentation1.23328613
68MP0005387_immune_system_phenotype1.22849271
69MP0001790_abnormal_immune_system1.22849271
70MP0000350_abnormal_cell_proliferation1.21964634
71MP0000598_abnormal_liver_morphology1.21707446
72MP0000313_abnormal_cell_death1.20838262
73MP0005083_abnormal_biliary_tract1.20689756
74MP0005330_cardiomyopathy1.20247421
75MP0003436_decreased_susceptibility_to1.19170679
76MP0001800_abnormal_humoral_immune1.18967565
77MP0002429_abnormal_blood_cell1.17706632
78MP0003191_abnormal_cellular_cholesterol1.17161651
79MP0005319_abnormal_enzyme/_coenzyme1.17129943
80MP0001666_abnormal_nutrient_absorption1.16451275
81MP0009697_abnormal_copulation1.15713837
82MP0005501_abnormal_skin_physiology1.15186674
83MP0002249_abnormal_larynx_morphology1.13826452
84MP0001873_stomach_inflammation1.13561869
85MP0003300_gastrointestinal_ulcer1.11404718
86MP0004947_skin_inflammation1.10172388
87MP0000716_abnormal_immune_system1.09794685
88MP0002148_abnormal_hypersensitivity_rea1.08830707
89MP0001853_heart_inflammation1.08586090
90MP0002877_abnormal_melanocyte_morpholog1.07541009
91MP0000681_abnormal_thyroid_gland1.06806136
92MP0006054_spinal_hemorrhage1.06327960
93MP0006035_abnormal_mitochondrial_morpho1.03585565
94MP0002080_prenatal_lethality1.03399648
95MP0000465_gastrointestinal_hemorrhage1.02796642
96MP0000759_abnormal_skeletal_muscle1.02473729
97MP0003566_abnormal_cell_adhesion1.02226676
98MP0010155_abnormal_intestine_physiology0.98747703
99MP0001849_ear_inflammation0.98409538
100MP0001697_abnormal_embryo_size0.97929359
101MP0005375_adipose_tissue_phenotype0.97536605
102MP0008877_abnormal_DNA_methylation0.95732304
103MP0002420_abnormal_adaptive_immunity0.95052073
104MP0009785_altered_susceptibility_to0.94171730
105MP0008469_abnormal_protein_level0.93393677
106MP0001819_abnormal_immune_cell0.93161338
107MP0009763_increased_sensitivity_to0.92975772
108MP0000358_abnormal_cell_content/0.92889202
109MP0005025_abnormal_response_to0.92543223
110MP0002723_abnormal_immune_serum0.91695314
111MP0002452_abnormal_antigen_presenting0.90328945
112MP0002405_respiratory_system_inflammati0.90268513
113MP0001929_abnormal_gametogenesis0.89510733
114MP0002796_impaired_skin_barrier0.89264158
115MP0002138_abnormal_hepatobiliary_system0.88507585
116MP0001533_abnormal_skeleton_physiology0.88276653
117MP0009643_abnormal_urine_homeostasis0.87392950
118MP0002166_altered_tumor_susceptibility0.86406089
119MP0002269_muscular_atrophy0.85788614
120MP0003868_abnormal_feces_composition0.85262533
121MP0010307_abnormal_tumor_latency0.85030444
122MP0003866_abnormal_defecation0.85008665
123MP0003646_muscle_fatigue0.84075461
124MP0003453_abnormal_keratinocyte_physiol0.81277716
125MP0000604_amyloidosis0.81077285
126MP0002970_abnormal_white_adipose0.80916917
127MP0000003_abnormal_adipose_tissue0.80786881
128MP0004147_increased_porphyrin_level0.80634287
129MP0002210_abnormal_sex_determination0.80188676
130MP0000372_irregular_coat_pigmentation0.80031308
131MP0005220_abnormal_exocrine_pancreas0.79160008
132MP0005380_embryogenesis_phenotype0.78050737
133MP0001672_abnormal_embryogenesis/_devel0.78050737
134MP0002009_preneoplasia0.77959801
135MP0005408_hypopigmentation0.77876564
136MP0005621_abnormal_cell_physiology0.77161160
137MP0005023_abnormal_wound_healing0.77110235
138MP0005584_abnormal_enzyme/coenzyme_acti0.77030767
139MP0002086_abnormal_extraembryonic_tissu0.76554116
140MP0001145_abnormal_male_reproductive0.76441752
141MP0001845_abnormal_inflammatory_respons0.76230943
142MP0000477_abnormal_intestine_morphology0.76057123
143MP0002095_abnormal_skin_pigmentation0.74940918
144MP0005174_abnormal_tail_pigmentation0.74136461
145MP0004019_abnormal_vitamin_homeostasis0.73641692

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.10469588
2Abnormal number of erythroid precursors (HP:0012131)4.10172027
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.06301348
4Hypobetalipoproteinemia (HP:0003563)4.00085918
5Oral leukoplakia (HP:0002745)3.84348779
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79146094
7Centrally nucleated skeletal muscle fibers (HP:0003687)3.64853603
8Aplastic anemia (HP:0001915)3.62662683
9Abnormality of pyrimidine metabolism (HP:0004353)3.59590457
10Ragged-red muscle fibers (HP:0003200)3.51454722
11Abnormal gallbladder physiology (HP:0012438)3.40337828
12Cholecystitis (HP:0001082)3.40337828
13Reticulocytopenia (HP:0001896)3.25895894
14Intrahepatic cholestasis (HP:0001406)3.23329495
15Colon cancer (HP:0003003)3.13181979
16Microvesicular hepatic steatosis (HP:0001414)3.04309658
17Hypoplasia of the thymus (HP:0000778)3.01060343
18Deep venous thrombosis (HP:0002625)2.98321802
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.95329639
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.95329639
21Fatigue (HP:0012378)2.90879610
22Birth length less than 3rd percentile (HP:0003561)2.81767027
23Exercise-induced myalgia (HP:0003738)2.79128879
24Thrombocytosis (HP:0001894)2.75343325
25IgM deficiency (HP:0002850)2.74543723
26Hypertensive crisis (HP:0100735)2.74178823
27Vertebral compression fractures (HP:0002953)2.71660666
28Agnosia (HP:0010524)2.65322490
29Macrocytic anemia (HP:0001972)2.64900722
30Rhabdomyolysis (HP:0003201)2.63375504
31Ependymoma (HP:0002888)2.63347787
32Hyperammonemia (HP:0001987)2.63206231
33Prolonged partial thromboplastin time (HP:0003645)2.63093494
34Petechiae (HP:0000967)2.60781585
35Distal lower limb muscle weakness (HP:0009053)2.59774342
36Long palpebral fissure (HP:0000637)2.58418375
37Rhabdomyosarcoma (HP:0002859)2.57349127
38Eczematoid dermatitis (HP:0000976)2.56104472
39Abnormality of the heme biosynthetic pathway (HP:0010472)2.53443887
40Achilles tendon contracture (HP:0001771)2.51558516
41Cellulitis (HP:0100658)2.50781812
42Abnormality of the Achilles tendon (HP:0005109)2.50259222
43Pallor (HP:0000980)2.49872698
44Cholelithiasis (HP:0001081)2.49508115
45Abnormality of methionine metabolism (HP:0010901)2.49046439
46Microretrognathia (HP:0000308)2.49032046
47Increased connective tissue (HP:0009025)2.47915452
48Myopathic facies (HP:0002058)2.45395424
49Progressive muscle weakness (HP:0003323)2.43929037
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.39790855
51Thoracic kyphosis (HP:0002942)2.39038478
523-Methylglutaconic aciduria (HP:0003535)2.38131262
53Xanthomatosis (HP:0000991)2.37589937
54Seborrheic dermatitis (HP:0001051)2.34437854
55Hypolipoproteinemia (HP:0010981)2.34248962
56Chronic obstructive pulmonary disease (HP:0006510)2.34210778
57Obstructive lung disease (HP:0006536)2.34210778
58Nausea (HP:0002018)2.33399192
59Distal lower limb amyotrophy (HP:0008944)2.32258812
60Gonadotropin excess (HP:0000837)2.32156802
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.31458950
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.28459149
63Reticulocytosis (HP:0001923)2.27553529
64Medulloblastoma (HP:0002885)2.27031597
65Dysostosis multiplex (HP:0000943)2.24977686
66Hyperbilirubinemia (HP:0002904)2.24017970
67Generalized aminoaciduria (HP:0002909)2.22906046
68Hemorrhage of the eye (HP:0011885)2.22769864
69Basal cell carcinoma (HP:0002671)2.21943270
70Abnormality of the thoracic spine (HP:0100711)2.20884345
71Pancytopenia (HP:0001876)2.20233191
72Abnormality of serum amino acid levels (HP:0003112)2.20174654
73Increased serum lactate (HP:0002151)2.19230644
74Premature graying of hair (HP:0002216)2.18584328
75Acute hepatic failure (HP:0006554)2.17927838
76Secondary amenorrhea (HP:0000869)2.17459185
77Colitis (HP:0002583)2.15462241
78Amaurosis fugax (HP:0100576)2.15227645
79Gastrointestinal inflammation (HP:0004386)2.14789492
80Trismus (HP:0000211)2.12891797
81Systemic lupus erythematosus (HP:0002725)2.11205567
82Spastic diplegia (HP:0001264)2.10666651
83Abnormality of skeletal muscle fiber size (HP:0012084)2.09653487
84Recurrent bronchitis (HP:0002837)2.09152911
85Abnormality of fatty-acid metabolism (HP:0004359)2.08789839
86Hyperacusis (HP:0010780)2.08060127
87Reduced antithrombin III activity (HP:0001976)2.05577126
88Rough bone trabeculation (HP:0100670)2.05048076
89Lymphoma (HP:0002665)2.04502565
90Hepatic necrosis (HP:0002605)2.04365971
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03713627
92Abnormality of alanine metabolism (HP:0010916)2.03713627
93Hyperalaninemia (HP:0003348)2.03713627
94Muscle fiber atrophy (HP:0100295)2.03136455
95Poikiloderma (HP:0001029)2.02540161
96Abnormality of reticulocytes (HP:0004312)2.02102212
97Abnormal gallbladder morphology (HP:0012437)2.01642895
98Cellular immunodeficiency (HP:0005374)2.01012096
99Increased cerebral lipofuscin (HP:0011813)2.00029616
100Increased muscle lipid content (HP:0009058)1.99450987
101Abnormality of macrophages (HP:0004311)1.98639577
102Recurrent abscess formation (HP:0002722)1.96968875
103Hyperlipoproteinemia (HP:0010980)1.96536970
104Dicarboxylic aciduria (HP:0003215)1.96180461
105Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96180461
106Ketosis (HP:0001946)1.95950925
107Agammaglobulinemia (HP:0004432)1.95222282
108Hyperglycinemia (HP:0002154)1.94866544
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94855257
110Epistaxis (HP:0000421)1.94796204
111Mediastinal lymphadenopathy (HP:0100721)1.94692424
112Combined immunodeficiency (HP:0005387)1.94515681
113Prolonged bleeding time (HP:0003010)1.93810226
114Elevated erythrocyte sedimentation rate (HP:0003565)1.93792995
115Hepatosplenomegaly (HP:0001433)1.93573636
116Neoplasm of the pancreas (HP:0002894)1.93458306
117Abnormality of nucleobase metabolism (HP:0010932)1.92913027
118Abnormality of the gallbladder (HP:0005264)1.92606948
119Degeneration of anterior horn cells (HP:0002398)1.92067542
120Abnormality of the anterior horn cell (HP:0006802)1.92067542
121Type 2 muscle fiber atrophy (HP:0003554)1.91653044
122Hypertriglyceridemia (HP:0002155)1.91557190
123Growth hormone excess (HP:0000845)1.91337032
124Myelodysplasia (HP:0002863)1.90563784
125Abnormality of the common coagulation pathway (HP:0010990)1.90057200
126Increased IgE level (HP:0003212)1.88876690
127Abnormal platelet volume (HP:0011876)1.88705981
128Myoglobinuria (HP:0002913)1.88538281
129Increased intramyocellular lipid droplets (HP:0012240)1.88243391
130Increased variability in muscle fiber diameter (HP:0003557)1.88095867
131Panhypogammaglobulinemia (HP:0003139)1.86999377
132Cerebral palsy (HP:0100021)1.86581064
13311 pairs of ribs (HP:0000878)1.86250835
134Asymmetric septal hypertrophy (HP:0001670)1.85965602
135Recurrent viral infections (HP:0004429)1.85907063
136Abnormality of B cell number (HP:0010975)1.84805862
137B lymphocytopenia (HP:0010976)1.84805862
138Breast hypoplasia (HP:0003187)1.84805030
139Increased serum ferritin (HP:0003281)1.84715393
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.84536458
141Megaloblastic anemia (HP:0001889)1.84034781
142Brushfield spots (HP:0001088)1.83949861
143Acanthocytosis (HP:0001927)1.83672170
144Abnormality of liposaccharide metabolism (HP:0010968)1.83585415
145Abnormality of glycosphingolipid metabolism (HP:0004343)1.83585415
146Abnormality of glycolipid metabolism (HP:0010969)1.83585415
147Diaphragmatic weakness (HP:0009113)1.83403903
148Easy fatigability (HP:0003388)1.83253306
149Premature ovarian failure (HP:0008209)1.82112777
150Abnormality of T cells (HP:0002843)1.81870807
151Purpura (HP:0000979)1.81855464
152Poikilocytosis (HP:0004447)1.80951568
153Impaired platelet aggregation (HP:0003540)1.80697805
154Abnormal platelet function (HP:0011869)1.80697805
155Joint hemorrhage (HP:0005261)1.80493767
156Microcytic anemia (HP:0001935)1.80448144
157Broad distal phalanx of finger (HP:0009836)1.80376524
158Abnormality of glycolysis (HP:0004366)1.79946167
159Polygenic inheritance (HP:0010982)1.79527065
160Polycythemia (HP:0001901)1.79467538
161Hypoglycemic coma (HP:0001325)1.78824433
162Abnormal spermatogenesis (HP:0008669)1.78436348
163Late onset (HP:0003584)1.77901275
164Hepatocellular necrosis (HP:0001404)1.77724880
165Gastrointestinal stroma tumor (HP:0100723)1.77074931
166Inflammation of the large intestine (HP:0002037)1.77005734
167Multiple enchondromatosis (HP:0005701)1.76632803
168Progressive external ophthalmoplegia (HP:0000590)1.75199718
169Testicular atrophy (HP:0000029)1.74568637
170Abnormality of the fingertips (HP:0001211)1.74143731
171Abnormality of iron homeostasis (HP:0011031)1.73709859
172Broad face (HP:0000283)1.73636891
173Prolonged neonatal jaundice (HP:0006579)1.72322074
174Nonimmune hydrops fetalis (HP:0001790)1.71980439
175Bulbar palsy (HP:0001283)1.70906023
176Athetosis (HP:0002305)1.70892214
177J-shaped sella turcica (HP:0002680)1.70026277
178Opisthotonus (HP:0002179)1.68255666
179Biconcave vertebral bodies (HP:0004586)1.68098095
180Progressive neurologic deterioration (HP:0002344)1.66405137
181Abnormality of the tricuspid valve (HP:0001702)1.65993382
182Meningitis (HP:0001287)1.65587517
183Recurrent bacterial skin infections (HP:0005406)1.64477126
184Increased IgM level (HP:0003496)1.63935612
185Stridor (HP:0010307)1.63690747
186Urticaria (HP:0001025)1.62178596
187Upper limb amyotrophy (HP:0009129)1.60174015
188Distal upper limb amyotrophy (HP:0007149)1.60174015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.68394476
2SMG13.26808466
3WEE13.22349610
4EIF2AK13.08751342
5NME22.97097161
6CDC72.90915855
7MAP4K12.81077904
8PRPF4B2.74322889
9TLK12.58227049
10BCKDK2.38539546
11ICK2.34330992
12NEK22.32158728
13STK162.31240801
14IRAK32.22774395
15KDR2.14159347
16VRK21.99424980
17EEF2K1.97421362
18EIF2AK31.97295241
19ACVR1B1.90581757
20SIK11.87116117
21TESK21.84945888
22MAP2K31.82516368
23MAPKAPK31.74006104
24ZAP701.67433386
25MAP3K101.66486452
26RPS6KB21.63863649
27FLT31.62866956
28PKN21.61377807
29ARAF1.59421371
30STK101.58239604
31TTK1.53553756
32ERN11.50525417
33TSSK61.46469772
34PASK1.45107667
35NEK11.41738837
36SCYL21.39016304
37PLK11.38514535
38VRK11.37791226
39AURKB1.37267521
40RPS6KA41.35641672
41MAP3K31.34516412
42ATR1.33417871
43TGFBR11.31198542
44TTN1.28806368
45MAP3K111.27502940
46BRSK21.25152937
47CDK71.23995117
48PRKD31.23626438
49TNK21.22939178
50CDK41.22506728
51BTK1.22359704
52BRSK11.17360170
53MAP3K81.15813563
54DYRK31.14715929
55KIT1.13801610
56GRK61.13620751
57MKNK11.13490809
58CCNB11.11745774
59PLK41.11613496
60TYK21.10107442
61SRPK11.09803503
62CDK81.06645064
63LRRK21.05065205
64TXK1.05017159
65RIPK41.04239188
66EPHB11.03409781
67AURKA1.00299246
68TEC0.97251744
69TAOK10.97147395
70MAPK110.94065106
71PIM20.92756750
72PIM10.91899673
73TRIB30.91709623
74DAPK10.91640658
75JAK30.90754991
76BLK0.90173137
77STK40.88143157
78MAP2K60.87393247
79TESK10.86588313
80FGFR40.85036759
81BRAF0.81788165
82FES0.81381534
83PAK40.81369160
84RPS6KC10.81326600
85RPS6KL10.81326600
86CHEK20.78829149
87MAP3K60.73498885
88IRAK40.73373712
89NEK90.73065136
90PRKD20.72895267
91MAPK120.72812273
92CDK90.72359798
93CSF1R0.70318120
94SYK0.68541739
95PDPK10.66647129
96CHEK10.64916775
97MAP3K10.64886491
98SIK30.64722949
99MAP2K20.64103494
100RPS6KA20.63448405
101KSR20.63265033
102TAOK20.61180859
103MTOR0.58803424
104EPHA20.58737761
105CSNK2A20.58517150
106CSNK2A10.56981768
107RPS6KA60.56500622
108ATM0.54718323
109MARK20.54292507
110CLK10.52632286
111MELK0.52121545
112HCK0.51499412
113IRAK20.51220697
114MAPK70.50855861
115RIPK10.50048217
116CDK20.49850143
117LYN0.49666793
118CDK190.48926546
119MARK30.48801058
120TAOK30.48379983
121RAF10.48089929
122TBK10.47866020
123HIPK20.47617745
124PAK10.44270835
125NLK0.43753251
126LMTK20.43300988
127MAPKAPK20.41778407
128MAP3K130.41710828
129PLK30.40865244
130PDK10.40768385
131ILK0.40574561
132BMX0.39765351
133RPS6KA10.38585040
134MKNK20.38505404
135PTK60.38445602
136LCK0.36955728
137IKBKB0.36896347
138MAP3K140.35773961
139MAPKAPK50.35625070
140RPS6KA50.34852865
141DYRK1B0.34783490
142CDK120.34278731
143MST1R0.33496169
144CDK60.33314840
145IKBKE0.32864132
146AKT20.31606793
147ITK0.29989730
148MAPK40.29705567

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24020965
2Mismatch repair_Homo sapiens_hsa034303.55698737
3Ribosome_Homo sapiens_hsa030102.90128167
4One carbon pool by folate_Homo sapiens_hsa006702.77734191
5Base excision repair_Homo sapiens_hsa034102.60710770
6Proteasome_Homo sapiens_hsa030502.36624843
7Homologous recombination_Homo sapiens_hsa034402.23309766
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21340074
9Nucleotide excision repair_Homo sapiens_hsa034202.19622325
10Pyrimidine metabolism_Homo sapiens_hsa002402.12982281
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.09171697
12Spliceosome_Homo sapiens_hsa030402.06916588
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.06655710
14RNA polymerase_Homo sapiens_hsa030201.96279644
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91465855
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.91194039
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.86361352
18RNA transport_Homo sapiens_hsa030131.83840286
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83550512
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76301512
21Acute myeloid leukemia_Homo sapiens_hsa052211.75294668
22Selenocompound metabolism_Homo sapiens_hsa004501.74028775
23Folate biosynthesis_Homo sapiens_hsa007901.69478941
24Sulfur relay system_Homo sapiens_hsa041221.66214186
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61693721
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.58919821
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56661330
28Fatty acid elongation_Homo sapiens_hsa000621.56051495
29Biosynthesis of amino acids_Homo sapiens_hsa012301.54843759
30Cell cycle_Homo sapiens_hsa041101.48454384
31Non-homologous end-joining_Homo sapiens_hsa034501.45495520
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42717094
33Pentose phosphate pathway_Homo sapiens_hsa000301.41871774
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.34726487
35Fanconi anemia pathway_Homo sapiens_hsa034601.34533723
36B cell receptor signaling pathway_Homo sapiens_hsa046621.31256195
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23612083
38Basal transcription factors_Homo sapiens_hsa030221.23583251
39Carbon metabolism_Homo sapiens_hsa012001.23504013
40Non-small cell lung cancer_Homo sapiens_hsa052231.20648474
41RNA degradation_Homo sapiens_hsa030181.20565340
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16655954
43Fatty acid degradation_Homo sapiens_hsa000711.15100393
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15082086
45Viral myocarditis_Homo sapiens_hsa054161.14784777
46Arginine biosynthesis_Homo sapiens_hsa002201.13901982
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13570993
48Tryptophan metabolism_Homo sapiens_hsa003801.13277391
49Peroxisome_Homo sapiens_hsa041461.13125048
50Chronic myeloid leukemia_Homo sapiens_hsa052201.11949142
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.08129832
52Leishmaniasis_Homo sapiens_hsa051401.07381877
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05912364
54Caffeine metabolism_Homo sapiens_hsa002321.05859894
55Prion diseases_Homo sapiens_hsa050201.04322781
56Bladder cancer_Homo sapiens_hsa052191.02140821
57Complement and coagulation cascades_Homo sapiens_hsa046101.00272672
58Pyruvate metabolism_Homo sapiens_hsa006201.00100166
59Pancreatic cancer_Homo sapiens_hsa052120.97500119
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96612504
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92935403
62Purine metabolism_Homo sapiens_hsa002300.91995880
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91666978
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90473826
65AMPK signaling pathway_Homo sapiens_hsa041520.90281078
66Osteoclast differentiation_Homo sapiens_hsa043800.90243532
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90164287
68Insulin signaling pathway_Homo sapiens_hsa049100.89738593
69Chemical carcinogenesis_Homo sapiens_hsa052040.88099282
70Protein export_Homo sapiens_hsa030600.86349408
71Propanoate metabolism_Homo sapiens_hsa006400.86339618
72Influenza A_Homo sapiens_hsa051640.85705334
73Primary immunodeficiency_Homo sapiens_hsa053400.85162658
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84313508
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84024426
76Hepatitis B_Homo sapiens_hsa051610.83872551
77Apoptosis_Homo sapiens_hsa042100.83629148
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83104557
79Galactose metabolism_Homo sapiens_hsa000520.81299098
80Systemic lupus erythematosus_Homo sapiens_hsa053220.79838151
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79105412
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77900667
83Nitrogen metabolism_Homo sapiens_hsa009100.77671248
84Notch signaling pathway_Homo sapiens_hsa043300.76736042
85beta-Alanine metabolism_Homo sapiens_hsa004100.76223536
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75385498
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75325448
88mRNA surveillance pathway_Homo sapiens_hsa030150.74273449
89Histidine metabolism_Homo sapiens_hsa003400.73595557
90Fructose and mannose metabolism_Homo sapiens_hsa000510.72695671
91Antigen processing and presentation_Homo sapiens_hsa046120.72682727
92Glutathione metabolism_Homo sapiens_hsa004800.72462771
93p53 signaling pathway_Homo sapiens_hsa041150.72100317
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72064236
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70997716
96Allograft rejection_Homo sapiens_hsa053300.70304289
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70084836
98Lysosome_Homo sapiens_hsa041420.69627273
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65452439
100Tuberculosis_Homo sapiens_hsa051520.65419675
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.63050674
102Vitamin B6 metabolism_Homo sapiens_hsa007500.62565565
103Retinol metabolism_Homo sapiens_hsa008300.62505370
104N-Glycan biosynthesis_Homo sapiens_hsa005100.62394986
105Autoimmune thyroid disease_Homo sapiens_hsa053200.61517975
106Tyrosine metabolism_Homo sapiens_hsa003500.61166391
107Toxoplasmosis_Homo sapiens_hsa051450.60437285
108Vibrio cholerae infection_Homo sapiens_hsa051100.59924636
109Herpes simplex infection_Homo sapiens_hsa051680.59103469
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57421958
111Hepatitis C_Homo sapiens_hsa051600.55024102
112Metabolic pathways_Homo sapiens_hsa011000.54002774
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54000259
114Phenylalanine metabolism_Homo sapiens_hsa003600.53811726
115VEGF signaling pathway_Homo sapiens_hsa043700.53783857
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.53702274
117Endocytosis_Homo sapiens_hsa041440.51163049
118Arginine and proline metabolism_Homo sapiens_hsa003300.51069046
119Epstein-Barr virus infection_Homo sapiens_hsa051690.49887144
120mTOR signaling pathway_Homo sapiens_hsa041500.49786568
121Graft-versus-host disease_Homo sapiens_hsa053320.49187103
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.49103819
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.47620062
124Insulin resistance_Homo sapiens_hsa049310.47404170
125Endometrial cancer_Homo sapiens_hsa052130.46720272
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45811605
127Fat digestion and absorption_Homo sapiens_hsa049750.45787371
128Fatty acid metabolism_Homo sapiens_hsa012120.45211474
129Lysine degradation_Homo sapiens_hsa003100.44324604
130Staphylococcus aureus infection_Homo sapiens_hsa051500.43950065
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.43228424
132PPAR signaling pathway_Homo sapiens_hsa033200.42883419
133Butanoate metabolism_Homo sapiens_hsa006500.41305418
134Starch and sucrose metabolism_Homo sapiens_hsa005000.40507141
135Sulfur metabolism_Homo sapiens_hsa009200.40041891
136Viral carcinogenesis_Homo sapiens_hsa052030.39020935
137Other glycan degradation_Homo sapiens_hsa005110.34197741
138ABC transporters_Homo sapiens_hsa020100.34010953
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.33063327
140Legionellosis_Homo sapiens_hsa051340.32680365
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32020916
142Thyroid cancer_Homo sapiens_hsa052160.29617869
143Shigellosis_Homo sapiens_hsa051310.28446714
144HTLV-I infection_Homo sapiens_hsa051660.27671875
145Measles_Homo sapiens_hsa051620.26263167
146Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24749720
147Vitamin digestion and absorption_Homo sapiens_hsa049770.22122710

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