EEPD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)6.48269760
2fatty acid transmembrane transport (GO:1902001)5.17612258
3valine metabolic process (GO:0006573)5.17413382
4regulation of sequestering of triglyceride (GO:0010889)5.15087076
5triglyceride catabolic process (GO:0019433)4.91953554
6alpha-linolenic acid metabolic process (GO:0036109)4.80963071
7neutrophil activation involved in immune response (GO:0002283)4.79550056
8response to peptidoglycan (GO:0032494)4.78380674
9carnitine shuttle (GO:0006853)4.66361123
10acylglycerol catabolic process (GO:0046464)4.62990473
11neutral lipid catabolic process (GO:0046461)4.62990473
12positive regulation of fatty acid beta-oxidation (GO:0032000)4.51082324
13plasma lipoprotein particle clearance (GO:0034381)4.41674500
14positive regulation of fatty acid oxidation (GO:0046321)4.31295429
15biotin metabolic process (GO:0006768)4.29520028
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.14237941
17glycosphingolipid catabolic process (GO:0046479)4.13796702
18regulation of mast cell degranulation (GO:0043304)4.13671119
19macrophage activation involved in immune response (GO:0002281)4.09369785
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.08697597
21negative regulation of interleukin-12 production (GO:0032695)4.08649038
22amino sugar catabolic process (GO:0046348)4.08529533
23complement activation, alternative pathway (GO:0006957)4.08511902
24regulation of cholesterol storage (GO:0010885)4.08390655
25brown fat cell differentiation (GO:0050873)4.07027674
26fatty acid homeostasis (GO:0055089)4.06855856
27fatty acid beta-oxidation (GO:0006635)4.04916339
28negative regulation of cell killing (GO:0031342)3.99025654
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99025654
30negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.98107868
31positive regulation of cellular amide metabolic process (GO:0034250)3.97620548
32oligosaccharide catabolic process (GO:0009313)3.96775949
33positive regulation of lipid catabolic process (GO:0050996)3.95832931
34cellular response to thyroid hormone stimulus (GO:0097067)3.91072973
35N-acetylneuraminate metabolic process (GO:0006054)3.90047452
36regulation of mast cell activation involved in immune response (GO:0033006)3.87326673
37detection of molecule of bacterial origin (GO:0032490)3.86193591
38positive regulation of mast cell degranulation (GO:0043306)3.78063837
39positive regulation of mast cell activation involved in immune response (GO:0033008)3.78063837
40carnitine transmembrane transport (GO:1902603)3.77402250
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74830192
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.74830192
43modulation by symbiont of host immune response (GO:0052553)3.74830192
44positive regulation by symbiont of host defense response (GO:0052509)3.74830192
45modulation by symbiont of host defense response (GO:0052031)3.74830192
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74830192
47regulation of leukocyte degranulation (GO:0043300)3.73845031
48fatty acid oxidation (GO:0019395)3.73471872
49lipid oxidation (GO:0034440)3.71416159
50positive regulation of mast cell activation (GO:0033005)3.70504828
51glycolipid catabolic process (GO:0019377)3.69899693
52fatty acid catabolic process (GO:0009062)3.69761581
53regulation of triglyceride catabolic process (GO:0010896)3.66875751
542-oxoglutarate metabolic process (GO:0006103)3.63859074
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.63150044
56acetyl-CoA metabolic process (GO:0006084)3.60985006
57barbed-end actin filament capping (GO:0051016)3.60888943
58branched-chain amino acid metabolic process (GO:0009081)3.59563285
59response to dietary excess (GO:0002021)3.57560191
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.57022459
61L-phenylalanine catabolic process (GO:0006559)3.57022459
62white fat cell differentiation (GO:0050872)3.56509040
63oxaloacetate metabolic process (GO:0006107)3.54984686
64positive regulation of leukocyte degranulation (GO:0043302)3.53787913
65response to muramyl dipeptide (GO:0032495)3.53762003
66sulfur amino acid catabolic process (GO:0000098)3.52928212
67regulation of fatty acid beta-oxidation (GO:0031998)3.52184191
68amino-acid betaine transport (GO:0015838)3.50606915
69carnitine transport (GO:0015879)3.50606915
70negative regulation of erythrocyte differentiation (GO:0045647)3.50466355
71branched-chain amino acid catabolic process (GO:0009083)3.50433775
72triglyceride biosynthetic process (GO:0019432)3.47697354
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.46218798
74L-phenylalanine metabolic process (GO:0006558)3.46218798
75phospholipid homeostasis (GO:0055091)3.44791906
76macrophage activation (GO:0042116)3.44056282
77positive regulation of fatty acid metabolic process (GO:0045923)3.43444478
78triglyceride metabolic process (GO:0006641)3.42779879
79regulation of fatty acid oxidation (GO:0046320)3.41865578
80glycerolipid catabolic process (GO:0046503)3.39656457
81triglyceride homeostasis (GO:0070328)3.38982748
82acylglycerol homeostasis (GO:0055090)3.38982748
83positive regulation of gamma-delta T cell activation (GO:0046645)3.38938230
84neutral lipid biosynthetic process (GO:0046460)3.36830757
85acylglycerol biosynthetic process (GO:0046463)3.36830757
86regulation of mast cell activation (GO:0033003)3.35534905
87detection of other organism (GO:0098543)3.34565285
88detection of external biotic stimulus (GO:0098581)3.31796441
89positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.31506690
90thioester biosynthetic process (GO:0035384)3.30441468
91acyl-CoA biosynthetic process (GO:0071616)3.30441468
92positive regulation of extracellular matrix organization (GO:1903055)3.26471329
93acylglycerol metabolic process (GO:0006639)3.25033906
94monocarboxylic acid catabolic process (GO:0072329)3.24519993
95fatty-acyl-CoA metabolic process (GO:0035337)3.22952397
96cellular extravasation (GO:0045123)3.22213174
97adenosine receptor signaling pathway (GO:0001973)3.20686209
98neutral lipid metabolic process (GO:0006638)3.20484191
99fatty-acyl-CoA biosynthetic process (GO:0046949)3.20031754
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.19431695
101ceramide catabolic process (GO:0046514)3.19231079
102lipid storage (GO:0019915)3.18112042
103positive regulation of sterol transport (GO:0032373)3.16361620
104positive regulation of cholesterol transport (GO:0032376)3.16361620
105intracellular lipid transport (GO:0032365)3.13249656
106antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13205441
107regulation of superoxide anion generation (GO:0032928)3.12976738
108microglial cell activation (GO:0001774)3.12948642
109granulocyte activation (GO:0036230)3.12613923
110positive regulation of cholesterol efflux (GO:0010875)3.10110570
111tricarboxylic acid metabolic process (GO:0072350)3.09045224
112regulation of mononuclear cell migration (GO:0071675)3.06242740
113response to thyroid hormone (GO:0097066)3.05027437
114phospholipid efflux (GO:0033700)3.04854979
115immunoglobulin mediated immune response (GO:0016064)3.04438914
116succinate metabolic process (GO:0006105)3.04156906
117neutrophil activation (GO:0042119)3.03788237
118regulation of interferon-beta biosynthetic process (GO:0045357)3.01813105
119negative regulation of granulocyte differentiation (GO:0030853)3.01619795
120regulation of macrophage chemotaxis (GO:0010758)3.01332242
121epithelial cell differentiation involved in prostate gland development (GO:0060742)3.01291586
122glycogen catabolic process (GO:0005980)3.00163034
123lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99693331
124positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99419953
125detection of biotic stimulus (GO:0009595)2.98413119
126long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97677296
127negative regulation of protein autophosphorylation (GO:0031953)2.97426783
128amino-acid betaine metabolic process (GO:0006577)2.97304025
129positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.96323571
130lipid particle organization (GO:0034389)2.95553906
131detection of bacterium (GO:0016045)2.94116640
132carnitine metabolic process (GO:0009437)2.93925202
133long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.93695218
134urea metabolic process (GO:0019627)2.93384412
135urea cycle (GO:0000050)2.93384412
136negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92890159
137germinal center formation (GO:0002467)2.90984453
138regulation of sterol transport (GO:0032371)2.90171755
139regulation of cholesterol transport (GO:0032374)2.90171755
140reverse cholesterol transport (GO:0043691)2.88815611
141regulation of protein activation cascade (GO:2000257)2.88188370
142short-chain fatty acid metabolic process (GO:0046459)2.87903577
143glucan catabolic process (GO:0009251)2.87193075
144regulation of macrophage derived foam cell differentiation (GO:0010743)2.85941039
145G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.85751920
146regulation of complement activation (GO:0030449)2.84574642
147protein-lipid complex remodeling (GO:0034368)2.83583254
148macromolecular complex remodeling (GO:0034367)2.83583254
149plasma lipoprotein particle remodeling (GO:0034369)2.83583254
150regulation of triglyceride metabolic process (GO:0090207)2.83005488
151regulation of regulated secretory pathway (GO:1903305)2.80897278
152positive regulation of triglyceride metabolic process (GO:0090208)2.79183402
153high-density lipoprotein particle remodeling (GO:0034375)2.78707322
154positive regulation of lipid storage (GO:0010884)2.78244950
155myeloid cell activation involved in immune response (GO:0002275)2.76161831
156acyl-CoA metabolic process (GO:0006637)2.75812409
157thioester metabolic process (GO:0035383)2.75812409
158positive regulation of macrophage cytokine production (GO:0060907)2.75709279
159negative regulation of lipid storage (GO:0010888)2.75611783
160nitrogen cycle metabolic process (GO:0071941)2.75529550
161regulation of cholesterol esterification (GO:0010872)2.74890827
162lipoprotein transport (GO:0042953)2.74428974
163coenzyme A biosynthetic process (GO:0015937)2.74014049
164lysine catabolic process (GO:0006554)2.72864391
165lysine metabolic process (GO:0006553)2.72864391
166regulation of gamma-delta T cell activation (GO:0046643)2.68031644
167T-helper 1 type immune response (GO:0042088)2.65508330
168membrane lipid catabolic process (GO:0046466)2.64829419
169respiratory burst (GO:0045730)2.62564344
170macrophage differentiation (GO:0030225)2.61650529
171regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.59687813
172regulation of macrophage cytokine production (GO:0010935)2.59274975
173chondroitin sulfate catabolic process (GO:0030207)2.58048517
174sphingolipid catabolic process (GO:0030149)2.56758690
175cellular response to arsenic-containing substance (GO:0071243)2.55187625
176positive regulation of monocyte chemotaxis (GO:0090026)2.49803961
177negative regulation of cytokine production involved in immune response (GO:0002719)2.48617970
178neutrophil chemotaxis (GO:0030593)2.47510143
179regulation of beta-amyloid formation (GO:1902003)2.47134561
180negative regulation of toll-like receptor signaling pathway (GO:0034122)2.43842531
181negative regulation of leukocyte mediated immunity (GO:0002704)2.42301464
182regulation of B cell receptor signaling pathway (GO:0050855)2.41710537
183positive regulation of lipoprotein lipase activity (GO:0051006)2.41093122
184positive regulation of triglyceride lipase activity (GO:0061365)2.41093122
185hydrogen peroxide biosynthetic process (GO:0050665)2.40582293
186neutrophil migration (GO:1990266)2.39831609
187regulation of gamma-delta T cell differentiation (GO:0045586)2.38879546
188response to host immune response (GO:0052572)2.38748859
189response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38748859
190pinocytosis (GO:0006907)2.38415479
191positive regulation of toll-like receptor signaling pathway (GO:0034123)2.37996885

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.50524688
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.10604077
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.60861777
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.15981141
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92960810
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.88777878
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.41851463
8CLOCK_20551151_ChIP-Seq_293T_Human2.89100326
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71973926
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50040295
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.46165782
12VDR_21846776_ChIP-Seq_THP-1_Human2.35416159
13VDR_24763502_ChIP-Seq_THP-1_Human2.34606417
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23287539
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.22830432
16GATA1_22025678_ChIP-Seq_K562_Human2.17779249
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08461289
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07923371
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00268046
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88514652
21SCL_19346495_ChIP-Seq_HPC-7_Human1.84966274
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.78721130
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78713525
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77627725
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74225267
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73342805
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73340339
28ZNF263_19887448_ChIP-Seq_K562_Human1.72881119
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70178681
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69895447
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.66638804
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61239783
33* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61017400
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.58398192
35BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56691343
36* SPI1_23547873_ChIP-Seq_NB4_Human1.56684552
37KDM2B_26808549_Chip-Seq_DND41_Human1.55168903
38TCF7_22412390_ChIP-Seq_EML_Mouse1.54293008
39PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.52260967
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51157686
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.50156152
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.48264414
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47972587
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46638689
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.45137578
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41075523
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40875075
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40730230
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.39088309
50MAF_26560356_Chip-Seq_TH1_Human1.38091730
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.35242224
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33746304
53TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.33645238
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32920826
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32526451
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31332134
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28662561
58MYC_22102868_ChIP-Seq_BL_Human1.28038773
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27297243
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.24296228
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23611681
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22969573
63* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21585509
64KDM2B_26808549_Chip-Seq_K562_Human1.21189380
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.20776392
66PU_27001747_Chip-Seq_BMDM_Mouse1.19612369
67PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.18707253
68* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16899402
69* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15858898
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.14125610
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.14125610
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13075232
73* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13009370
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12824154
75EZH2_22144423_ChIP-Seq_EOC_Human1.12052333
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12038911
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.11179867
78UTX_26944678_Chip-Seq_JUKART_Human1.11107738
79* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10640869
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10458083
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10404917
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09483937
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09420304
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09420304
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08687521
86* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08427481
87VDR_24787735_ChIP-Seq_THP-1_Human1.06014739
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05658757
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04777616
90MAF_26560356_Chip-Seq_TH2_Human1.04272413
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03171059
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02178761
93* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01415952
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00058308
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99652955
96* BCL6_27268052_Chip-Seq_Bcells_Human0.99586716
97NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98157408
98KDM2B_26808549_Chip-Seq_JURKAT_Human0.97024760
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96714986
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96701132
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96405612
102* CJUN_26792858_Chip-Seq_BT549_Human0.95082156
103* BCOR_27268052_Chip-Seq_Bcells_Human0.94617929
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94588978
105RACK7_27058665_Chip-Seq_MCF-7_Human0.94030083
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92857718
107MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92167938
108GATA2_19941826_ChIP-Seq_K562_Human0.89469122
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89041983
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88908435
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.88292849
112* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88132398
113SA1_27219007_Chip-Seq_ERYTHROID_Human0.87880520
114SOX2_20726797_ChIP-Seq_SW620_Human0.86598037
115IRF8_27001747_Chip-Seq_BMDM_Mouse0.84081924
116GATA1_19941826_ChIP-Seq_K562_Human0.82910815
117* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81977109
118BCAT_22108803_ChIP-Seq_LS180_Human0.81966976
119EGR1_19032775_ChIP-ChIP_M12_Human0.81186203
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80791752
121LXR_22292898_ChIP-Seq_THP-1_Human0.80097155
122ESR1_21235772_ChIP-Seq_MCF-7_Human0.79034087
123MTF2_20144788_ChIP-Seq_MESCs_Mouse0.77342002
124IRF8_21731497_ChIP-ChIP_J774_Mouse0.76961566
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76482669
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75543058
127* HNF4A_19822575_ChIP-Seq_HepG2_Human0.75312329
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74048779
129RUNX_20019798_ChIP-Seq_JUKART_Human0.72239880
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.71323823
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.69300345
132KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69014059
133SPI1_23127762_ChIP-Seq_K562_Human0.68402664
134KLF4_19829295_ChIP-Seq_ESCs_Human0.68396331
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.66684048
136* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66224276
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.66211327
138HTT_18923047_ChIP-ChIP_STHdh_Human0.66071230
139EZH2_18974828_ChIP-Seq_MESCs_Mouse0.65895536
140RNF2_18974828_ChIP-Seq_MESCs_Mouse0.65895536
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65881116
142TRIM28_21343339_ChIP-Seq_HEK293_Human0.65050053
143SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.64469558
144SPI1_20517297_ChIP-Seq_HL60_Human0.63960452
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.63353962
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63200171
147SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63130043
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.62909919
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.62846345
150* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.61906519
151AR_25329375_ChIP-Seq_VCAP_Human0.61903627
152SOX2_27498859_Chip-Seq_STOMACH_Mouse0.61822741
153SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.60817703
154PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.59499703
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59466776
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.59448044
157ERG_21242973_ChIP-ChIP_JURKAT_Human0.59204606
158RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58895300

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.03944377
2MP0004130_abnormal_muscle_cell4.12135045
3MP0002139_abnormal_hepatobiliary_system3.89378878
4MP0002837_dystrophic_cardiac_calcinosis3.48445442
5MP0005360_urolithiasis3.38071442
6MP0005666_abnormal_adipose_tissue3.35580456
7MP0010329_abnormal_lipoprotein_level3.29786667
8MP0003303_peritoneal_inflammation3.15818480
9MP0005365_abnormal_bile_salt3.11108067
10MP0003191_abnormal_cellular_cholesterol2.92352548
11MP0003172_abnormal_lysosome_physiology2.80028993
12MP0004185_abnormal_adipocyte_glucose2.79646943
13MP0002419_abnormal_innate_immunity2.73250958
14MP0006082_CNS_inflammation2.61807427
15MP0003300_gastrointestinal_ulcer2.53784969
16MP0002876_abnormal_thyroid_physiology2.45644128
17MP0005375_adipose_tissue_phenotype2.39402273
18MP0005085_abnormal_gallbladder_physiolo2.35323503
19MP0002971_abnormal_brown_adipose2.25020315
20MP0003646_muscle_fatigue2.20557597
21MP0002118_abnormal_lipid_homeostasis2.18826888
22MP0002148_abnormal_hypersensitivity_rea2.17162638
23MP0009840_abnormal_foam_cell2.09851711
24MP0005334_abnormal_fat_pad2.08861768
25MP0000685_abnormal_immune_system2.08418477
26MP0000013_abnormal_adipose_tissue2.07336300
27MP0008875_abnormal_xenobiotic_pharmacok2.04874103
28MP0005025_abnormal_response_to2.03214891
29MP0000751_myopathy2.01440163
30MP0000749_muscle_degeneration1.95888963
31MP0009115_abnormal_fat_cell1.89704794
32MP0005000_abnormal_immune_tolerance1.88503541
33MP0001835_abnormal_antigen_presentation1.83401414
34MP0002998_abnormal_bone_remodeling1.83070065
35MP0001533_abnormal_skeleton_physiology1.82581080
36MP0009785_altered_susceptibility_to1.82211543
37MP0005387_immune_system_phenotype1.80096226
38MP0001790_abnormal_immune_system1.80096226
39MP0004510_myositis1.78839990
40MP0003690_abnormal_glial_cell1.76310480
41MP0002452_abnormal_antigen_presenting1.76283678
42MP0003183_abnormal_peptide_metabolism1.72658625
43MP0005451_abnormal_body_composition1.71462663
44MP0002723_abnormal_immune_serum1.71083730
45MP0000609_abnormal_liver_physiology1.66638344
46MP0005535_abnormal_body_temperature1.66139735
47MP0009278_abnormal_bone_marrow1.64470590
48MP0008438_abnormal_cutaneous_collagen1.62964470
49MP0003806_abnormal_nucleotide_metabolis1.62230554
50MP0005671_abnormal_response_to1.58818931
51MP0004036_abnormal_muscle_relaxation1.55471035
52MP0004145_abnormal_muscle_electrophysio1.53780735
53MP0001800_abnormal_humoral_immune1.53487032
54MP0008260_abnormal_autophagy1.52461615
55MP0003252_abnormal_bile_duct1.51945619
56MP0002420_abnormal_adaptive_immunity1.51822161
57MP0000003_abnormal_adipose_tissue1.49933914
58MP0001819_abnormal_immune_cell1.49376056
59MP0000920_abnormal_myelination1.48617714
60MP0005319_abnormal_enzyme/_coenzyme1.42000427
61MP0002405_respiratory_system_inflammati1.41971513
62MP0006036_abnormal_mitochondrial_physio1.41019957
63MP0003186_abnormal_redox_activity1.38915990
64MP0003705_abnormal_hypodermis_morpholog1.38456169
65MP0003724_increased_susceptibility_to1.38452382
66MP0005332_abnormal_amino_acid1.37967308
67MP0005166_decreased_susceptibility_to1.37451378
68MP0005083_abnormal_biliary_tract1.37039523
69MP0005584_abnormal_enzyme/coenzyme_acti1.36558068
70MP0001986_abnormal_taste_sensitivity1.34777367
71MP0005464_abnormal_platelet_physiology1.34493676
72MP0001845_abnormal_inflammatory_respons1.33064785
73MP0004087_abnormal_muscle_fiber1.31448910
74MP0005448_abnormal_energy_balance1.29636838
75MP0005620_abnormal_muscle_contractility1.29310260
76MP0002970_abnormal_white_adipose1.27680006
77MP0004147_increased_porphyrin_level1.26083338
78MP0000343_altered_response_to1.23753569
79MP0001661_extended_life_span1.21899939
80MP0000604_amyloidosis1.21585116
81MP0005058_abnormal_lysosome_morphology1.21404721
82MP0003828_pulmonary_edema1.20828743
83MP0001764_abnormal_homeostasis1.20818490
84MP0002078_abnormal_glucose_homeostasis1.20165626
85MP0000858_altered_metastatic_potential1.18522467
86MP0000759_abnormal_skeletal_muscle1.18228730
87MP0002735_abnormal_chemical_nociception1.16234279
88MP0004858_abnormal_nervous_system1.15449740
89MP0004947_skin_inflammation1.14039747
90MP0001666_abnormal_nutrient_absorption1.13516077
91MP0000465_gastrointestinal_hemorrhage1.13213811
92MP0000747_muscle_weakness1.11440179
93MP0004233_abnormal_muscle_weight1.10875051
94MP0005310_abnormal_salivary_gland1.10443809
95MP0002332_abnormal_exercise_endurance1.10137280
96MP0003634_abnormal_glial_cell1.09384536
97MP0002653_abnormal_ependyma_morphology1.08246682
98MP0010155_abnormal_intestine_physiology1.07056620
99MP0003656_abnormal_erythrocyte_physiolo1.05455073
100MP0003959_abnormal_lean_body1.05412215
101MP0000750_abnormal_muscle_regeneration1.05057174
102MP0002269_muscular_atrophy1.04666051
103MP0003453_abnormal_keratinocyte_physiol1.02407366
104MP0003075_altered_response_to1.01295234
105MP0002106_abnormal_muscle_physiology0.99515952
106MP0005397_hematopoietic_system_phenotyp0.99183667
107MP0001545_abnormal_hematopoietic_system0.99183667
108MP0002254_reproductive_system_inflammat0.97300984
109MP0005275_abnormal_skin_tensile0.96536409
110MP0002277_abnormal_respiratory_mucosa0.96328131
111MP0000716_abnormal_immune_system0.95885223
112MP0002972_abnormal_cardiac_muscle0.94305448
113MP0006276_abnormal_autonomic_nervous0.92022096
114MP0003329_amyloid_beta_deposits0.90165496
115MP0003633_abnormal_nervous_system0.90022350
116MP0002909_abnormal_adrenal_gland0.89867271
117MP0000249_abnormal_blood_vessel0.89611089
118MP0008004_abnormal_stomach_pH0.89339978
119MP0003448_altered_tumor_morphology0.89056034
120MP0004215_abnormal_myocardial_fiber0.88931751
121MP0008775_abnormal_heart_ventricle0.87778840
122MP0005452_abnormal_adipose_tissue0.87557829
123MP0009780_abnormal_chondrocyte_physiolo0.87068211
124MP0005330_cardiomyopathy0.84932520
125MP0009333_abnormal_splenocyte_physiolog0.84628707
126MP0001851_eye_inflammation0.83983855
127MP0009764_decreased_sensitivity_to0.83971818
128MP0005385_cardiovascular_system_phenoty0.83770032
129MP0001544_abnormal_cardiovascular_syste0.83770032
130MP0004270_analgesia0.83461625
131MP0009643_abnormal_urine_homeostasis0.81631406
132MP0001501_abnormal_sleep_pattern0.80426884
133MP0003045_fibrosis0.79263428
134MP0003091_abnormal_cell_migration0.78799752
135MP0003436_decreased_susceptibility_to0.77681312
136MP0005390_skeleton_phenotype0.76096979
137MP0000230_abnormal_systemic_arterial0.76084275
138MP0000689_abnormal_spleen_morphology0.74769003
139MP0008961_abnormal_basal_metabolism0.74708339
140MP0003011_delayed_dark_adaptation0.74666527
141MP0006138_congestive_heart_failure0.74415850
142MP0002733_abnormal_thermal_nociception0.73422169
143MP0005369_muscle_phenotype0.73301552
144MP0005595_abnormal_vascular_smooth0.72336009
145MP0002736_abnormal_nociception_after0.71217797
146MP0003795_abnormal_bone_structure0.70696193
147MP0001756_abnormal_urination0.70536936
148MP0009763_increased_sensitivity_to0.70063603
149MP0005164_abnormal_response_to0.69794091
150MP0003632_abnormal_nervous_system0.69395411
151MP0005165_increased_susceptibility_to0.68753410
152MP0001968_abnormal_touch/_nociception0.68657151
153MP0001853_heart_inflammation0.68522628
154MP0000598_abnormal_liver_morphology0.68417504
155MP0003279_aneurysm0.68389041
156MP0004883_abnormal_blood_vessel0.67036250
157MP0008469_abnormal_protein_level0.66975905
158MP0002398_abnormal_bone_marrow0.66285865
159MP0002933_joint_inflammation0.65920292
160MP0005167_abnormal_blood-brain_barrier0.63773810

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)6.98751668
2Abnormality of glycosphingolipid metabolism (HP:0004343)6.98751668
3Abnormality of glycolipid metabolism (HP:0010969)6.98751668
4Oligomenorrhea (HP:0000876)5.29647401
5Increased cerebral lipofuscin (HP:0011813)5.12665052
6Vacuolated lymphocytes (HP:0001922)5.08462197
7Abnormality of macrophages (HP:0004311)4.55973007
8Complement deficiency (HP:0004431)4.47777062
9Eczematoid dermatitis (HP:0000976)4.46475371
10Dysostosis multiplex (HP:0000943)4.43579231
11Loss of speech (HP:0002371)4.17841422
12Recurrent abscess formation (HP:0002722)4.12643581
13Increased neuronal autofluorescent lipopigment (HP:0002074)4.02978763
14Disinhibition (HP:0000734)3.99549457
15Exercise-induced myalgia (HP:0003738)3.93882274
16Myoglobinuria (HP:0002913)3.86856155
17Xanthomatosis (HP:0000991)3.85973950
18Hyperglycinuria (HP:0003108)3.85644781
19Neurofibrillary tangles (HP:0002185)3.84514271
20Hypertriglyceridemia (HP:0002155)3.78111951
21Hypoalphalipoproteinemia (HP:0003233)3.73799611
22Recurrent bacterial skin infections (HP:0005406)3.71457395
23Mutism (HP:0002300)3.67348575
24Acanthosis nigricans (HP:0000956)3.60278758
25Ketosis (HP:0001946)3.44206590
26Abnormality of glycine metabolism (HP:0010895)3.43847667
27Abnormality of serine family amino acid metabolism (HP:0010894)3.43847667
28Abnormality of polysaccharide metabolism (HP:0011012)3.42706518
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.42706518
30Abnormality of mucopolysaccharide metabolism (HP:0011020)3.42706518
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.39739735
32Difficulty running (HP:0009046)3.39427221
33Deep venous thrombosis (HP:0002625)3.26581866
34Myotonia (HP:0002486)3.26351363
35Mediastinal lymphadenopathy (HP:0100721)3.25894773
36Urinary glycosaminoglycan excretion (HP:0003541)3.25596355
37Mucopolysacchariduria (HP:0008155)3.25596355
38Hyperlipoproteinemia (HP:0010980)3.24119176
39Exercise-induced muscle cramps (HP:0003710)3.22272071
40Abnormality of complement system (HP:0005339)3.18331280
41Distal arthrogryposis (HP:0005684)3.14564377
42Hyporeflexia of lower limbs (HP:0002600)3.14423787
43Hyperammonemia (HP:0001987)3.11198950
44Rhabdomyolysis (HP:0003201)3.10032658
45Ketoacidosis (HP:0001993)3.04727136
46Hypolipoproteinemia (HP:0010981)3.03528676
47Systemic lupus erythematosus (HP:0002725)3.01340237
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.01131806
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00840515
50Nuclear cataract (HP:0100018)3.00483328
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98460195
52Muscle stiffness (HP:0003552)2.97908555
53Abnormality of fatty-acid metabolism (HP:0004359)2.96961157
54Increased connective tissue (HP:0009025)2.94240339
55Hypercholesterolemia (HP:0003124)2.93620787
56Muscle fiber inclusion bodies (HP:0100299)2.93317814
57Hyperglycinemia (HP:0002154)2.93205218
58Spontaneous hematomas (HP:0007420)2.92033136
59Epidermoid cyst (HP:0200040)2.91700510
60Muscle hypertrophy of the lower extremities (HP:0008968)2.88369650
61Myositis (HP:0100614)2.84432737
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.78383839
63Asymmetric septal hypertrophy (HP:0001670)2.77813906
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.77593545
65Cerebral inclusion bodies (HP:0100314)2.77336790
66Hypoglycemic coma (HP:0001325)2.76646636
67Stomatitis (HP:0010280)2.75632196
68Orchitis (HP:0100796)2.74213598
69Facial diplegia (HP:0001349)2.71172300
70Calf muscle hypertrophy (HP:0008981)2.69705395
71Pigmentary retinal degeneration (HP:0001146)2.69310359
72Myocardial infarction (HP:0001658)2.67321669
73Muscle fiber splitting (HP:0003555)2.66919413
74Type 1 muscle fiber predominance (HP:0003803)2.64089371
75Nemaline bodies (HP:0003798)2.62011375
76Purpura (HP:0000979)2.59458683
77Insulin-resistant diabetes mellitus (HP:0000831)2.58911131
78Hepatosplenomegaly (HP:0001433)2.58356538
79Intrahepatic cholestasis (HP:0001406)2.57255042
80Hemorrhage of the eye (HP:0011885)2.55800631
81Neuronal loss in central nervous system (HP:0002529)2.54524751
82Upper motor neuron abnormality (HP:0002127)2.53034782
83Gingivitis (HP:0000230)2.51922724
84Obstructive lung disease (HP:0006536)2.50748031
85Chronic obstructive pulmonary disease (HP:0006510)2.50748031
86Increased CSF protein (HP:0002922)2.50404873
87Cholelithiasis (HP:0001081)2.48749725
88Autoimmune thrombocytopenia (HP:0001973)2.44004912
89Abnormal gallbladder physiology (HP:0012438)2.41812062
90Cholecystitis (HP:0001082)2.41812062
91Abnormal gallbladder morphology (HP:0012437)2.41070866
92Retinal atrophy (HP:0001105)2.37443330
93Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.37089403
94Frequent falls (HP:0002359)2.36393029
95Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35751224
96Palpitations (HP:0001962)2.33569287
97Nausea (HP:0002018)2.32572438
98Hypobetalipoproteinemia (HP:0003563)2.32092534
99Amyloidosis (HP:0011034)2.32017695
100Pathologic fracture (HP:0002756)2.30738795
101Retrobulbar optic neuritis (HP:0100654)2.30325302
102Optic neuritis (HP:0100653)2.30325302
103Skin nodule (HP:0200036)2.30268981
104Apathy (HP:0000741)2.29647454
105Abnormality of glutamine family amino acid metabolism (HP:0010902)2.29640348
106Axonal loss (HP:0003447)2.29388366
107Diminished motivation (HP:0000745)2.28650780
108Agnosia (HP:0010524)2.25805611
109Inappropriate behavior (HP:0000719)2.25009747
110Hydroxyprolinuria (HP:0003080)2.22140682
111Abnormality of proline metabolism (HP:0010907)2.22140682
112Dicarboxylic aciduria (HP:0003215)2.20983340
113Abnormality of dicarboxylic acid metabolism (HP:0010995)2.20983340
114Prolonged neonatal jaundice (HP:0006579)2.19387991
115Dementia (HP:0000726)2.17893397
116Recurrent gram-negative bacterial infections (HP:0005420)2.17714038
117Joint hemorrhage (HP:0005261)2.16915781
118Peripheral demyelination (HP:0011096)2.15386111
119Abnormality of the periventricular white matter (HP:0002518)2.14184209
120Progressive neurologic deterioration (HP:0002344)2.13791975
121EMG: myopathic abnormalities (HP:0003458)2.13702239
122Prolonged partial thromboplastin time (HP:0003645)2.11967822
123Vertebral compression fractures (HP:0002953)2.11613994
124Pancreatitis (HP:0001733)2.10166091
125Abnormality of purine metabolism (HP:0004352)2.09633664
126Lipoatrophy (HP:0100578)2.07938080
127Increased serum ferritin (HP:0003281)2.06677922
128Increased muscle lipid content (HP:0009058)2.04658164
129Insulin resistance (HP:0000855)2.04403033
130Bone cyst (HP:0012062)2.02253658
131Recurrent skin infections (HP:0001581)2.01875478
132Cellulitis (HP:0100658)2.00441290
133Metabolic acidosis (HP:0001942)1.97823970
134Polyneuropathy (HP:0001271)1.97429901
135Bulbar palsy (HP:0001283)1.96137987
136Pulmonary infiltrates (HP:0002113)1.95676017
137Increased variability in muscle fiber diameter (HP:0003557)1.95398389
138Right ventricular cardiomyopathy (HP:0011663)1.94870553
139Growth hormone excess (HP:0000845)1.94839926
140Pheochromocytoma (HP:0002666)1.93254975
141Petechiae (HP:0000967)1.92859949
142Absent phalangeal crease (HP:0006109)1.92374559
143Urticaria (HP:0001025)1.91414004
144Supranuclear gaze palsy (HP:0000605)1.90067407
145Myopathic facies (HP:0002058)1.89733821
146Hyperglycemia (HP:0003074)1.89262514
147Late onset (HP:0003584)1.89233219
148Tetraparesis (HP:0002273)1.89105205
149Hematochezia (HP:0002573)1.88701464
150Abnormality of skeletal muscle fiber size (HP:0012084)1.88228462
151Personality changes (HP:0000751)1.88221085
152Hyperbilirubinemia (HP:0002904)1.86603448
153Meningitis (HP:0001287)1.86145248
154Basal ganglia calcification (HP:0002135)1.85251635
155Neuroendocrine neoplasm (HP:0100634)1.85126320
156Recurrent fungal infections (HP:0002841)1.82203612
157Sudden death (HP:0001699)1.82160504
158Centrally nucleated skeletal muscle fibers (HP:0003687)1.82105193
159Elevated erythrocyte sedimentation rate (HP:0003565)1.79368851
160Abnormality of serum amino acid levels (HP:0003112)1.78675846
161Reduced subcutaneous adipose tissue (HP:0003758)1.78618832
162Bone pain (HP:0002653)1.77795858
163Lethargy (HP:0001254)1.77160186
164Rapidly progressive (HP:0003678)1.76803613
165Abnormality of the common coagulation pathway (HP:0010990)1.76574097
166Thoracic kyphosis (HP:0002942)1.75906261
167Cerebral edema (HP:0002181)1.75669264
168Nephritis (HP:0000123)1.75352509
169Cardiomegaly (HP:0001640)1.75232623
170Glomerulonephritis (HP:0000099)1.74040382
171Hepatic necrosis (HP:0002605)1.73685438
172Hemiplegia (HP:0002301)1.72152269
173Neck muscle weakness (HP:0000467)1.71763607
174Sensorimotor neuropathy (HP:0007141)1.70599406
175Distal lower limb muscle weakness (HP:0009053)1.70026966
176Abnormality of nucleobase metabolism (HP:0010932)1.69715245
177Restrictive lung disease (HP:0002091)1.68307724
178Progressive visual loss (HP:0000529)1.68119576
179Global brain atrophy (HP:0002283)1.65683177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.28401722
2TRIB33.85652512
3CAMK1D3.81326406
4BCKDK3.77566687
5SIK13.16578586
6PHKG22.90617664
7PHKG12.90617664
8CAMK1G2.63878208
9OBSCN2.63203995
10MAP3K112.25631936
11TTN2.20694165
12RIPK12.17814995
13MAP4K12.05892452
14CSK1.94873305
15FES1.87952500
16KSR21.81498181
17PRPF4B1.81459695
18MST1R1.79334853
19PINK11.71334521
20ERN11.70655944
21TNK21.69537720
22MAP3K31.65531201
23PIK3CA1.64962568
24PDK41.62388262
25PDK31.62388262
26FGR1.59924587
27CSF1R1.55249491
28ZAP701.52841186
29MAP2K41.50313247
30MAP3K131.46144971
31TYK21.45701832
32INSRR1.44384221
33TAOK11.43273550
34MAPK151.39350780
35FGFR41.37732332
36GRK71.37014871
37DDR21.33669593
38MAP2K11.33288163
39FGFR31.32788720
40PRKAA21.30610605
41NEK91.29067986
42TESK21.28235544
43MAP2K31.25678480
44MAP3K21.25454126
45GRK51.22287529
46TAOK21.18268683
47FRK1.13676712
48MARK21.11728353
49RET1.11316323
50NTRK11.10278136
51RIPK41.09742773
52DAPK21.09465492
53PKN21.07539573
54JAK11.07020062
55MYLK1.04338968
56IKBKE1.03146023
57PDK21.00144038
58ICK0.99318448
59HCK0.99198342
60SYK0.99077334
61MOS0.98983166
62PIK3CG0.96821953
63JAK20.95853623
64ARAF0.93613755
65TIE10.92809405
66LYN0.92499700
67PTK2B0.92125875
68MAPK120.90024165
69IKBKB0.88289322
70MAPK70.87779832
71CAMKK20.86643521
72CDC42BPA0.83761819
73EPHB10.82951941
74FER0.82716920
75PDPK10.78411447
76PRKD30.77532773
77TBK10.76282909
78PRKAA10.75454205
79TGFBR20.75242983
80PRKD20.75089460
81MAP3K140.73399701
82BTK0.72995211
83SGK30.70547453
84PRKG20.68938457
85EPHA30.68712975
86MAP3K70.68600309
87JAK30.67103139
88GRK60.66892782
89MAPK110.65530971
90PDK10.65362938
91MARK30.64991509
92SGK20.64974056
93PAK40.64518138
94CAMK40.63771295
95PRKCH0.63051183
96SIK30.62084492
97IRAK30.61209252
98CDK60.60820122
99MAP3K10.60069478
100PDGFRA0.58271213
101BLK0.57014383
102MAPKAPK30.56961044
103PRKACG0.56109182
104LCK0.55873889
105TESK10.55866363
106RPS6KC10.55084740
107RPS6KL10.55084740
108SGK4940.55045670
109SGK2230.55045670
110LRRK20.55018776
111MATK0.54550159
112IRAK10.54426676
113PTK60.53754665
114CDK90.53335066
115MINK10.52249917
116PKN10.51818588
117MAP3K50.50691241
118RPS6KA20.50279081
119KSR10.49800133
120FGFR20.48630512
121PRKD10.48153273
122ACVR1B0.47696020
123IRAK20.47571618
124NME20.47412576
125FLT30.47315830
126LIMK10.47094130
127STK100.46843215
128ABL20.45745941
129IGF1R0.45180900
130ROCK20.44626008
131MET0.44457570
132TXK0.43143866
133MAP2K60.42451519
134MAP3K60.39779925
135MAP2K20.39425127
136STK240.39177058
137IRAK40.37574484
138MAPK40.36570550
139CAMKK10.35950413
140NEK10.35668898
141GSK3A0.35214818
142MAP3K90.34570964
143LATS20.34071281
144CAMK10.33717804
145KIT0.33212222
146ERBB40.31596792
147MAP3K120.30943244
148TRPM70.30370321
149EPHB20.30305683

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.51402343
2PPAR signaling pathway_Homo sapiens_hsa033203.20582131
3Propanoate metabolism_Homo sapiens_hsa006403.20010686
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.01802530
5Osteoclast differentiation_Homo sapiens_hsa043802.92787120
6Fatty acid degradation_Homo sapiens_hsa000712.74262444
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.58708359
8Fatty acid metabolism_Homo sapiens_hsa012122.58643796
9Nitrogen metabolism_Homo sapiens_hsa009102.44640237
10Fatty acid biosynthesis_Homo sapiens_hsa000612.43473735
11Leishmaniasis_Homo sapiens_hsa051402.41300757
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.38752063
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33013317
14Caffeine metabolism_Homo sapiens_hsa002322.29873125
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10721255
16Glycerolipid metabolism_Homo sapiens_hsa005612.08155175
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.05274886
18Tuberculosis_Homo sapiens_hsa051522.02963403
19Pyruvate metabolism_Homo sapiens_hsa006202.02385499
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01511577
21Arginine biosynthesis_Homo sapiens_hsa002201.94545680
22beta-Alanine metabolism_Homo sapiens_hsa004101.88299021
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.87506201
24Peroxisome_Homo sapiens_hsa041461.87044041
25Complement and coagulation cascades_Homo sapiens_hsa046101.86259278
26Staphylococcus aureus infection_Homo sapiens_hsa051501.83208353
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82376440
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77707250
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75143440
30Butanoate metabolism_Homo sapiens_hsa006501.71380830
31Malaria_Homo sapiens_hsa051441.67561728
32Starch and sucrose metabolism_Homo sapiens_hsa005001.64230440
33Fat digestion and absorption_Homo sapiens_hsa049751.63651814
34Rheumatoid arthritis_Homo sapiens_hsa053231.62360458
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61503326
36Tryptophan metabolism_Homo sapiens_hsa003801.60779845
37Carbon metabolism_Homo sapiens_hsa012001.60586688
38B cell receptor signaling pathway_Homo sapiens_hsa046621.55284551
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.51169299
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45511714
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41876818
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41032744
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40691386
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31143672
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29078977
46Antigen processing and presentation_Homo sapiens_hsa046121.28021303
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26587498
48Legionellosis_Homo sapiens_hsa051341.26094617
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24145985
50Phenylalanine metabolism_Homo sapiens_hsa003601.23734897
51Toxoplasmosis_Homo sapiens_hsa051451.23604737
52Salmonella infection_Homo sapiens_hsa051321.23565655
53TNF signaling pathway_Homo sapiens_hsa046681.21779268
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19701382
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.17909063
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15189709
57ABC transporters_Homo sapiens_hsa020101.14128455
58Allograft rejection_Homo sapiens_hsa053301.13259531
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12869124
60Insulin resistance_Homo sapiens_hsa049311.12373900
61Fatty acid elongation_Homo sapiens_hsa000621.12062332
62AMPK signaling pathway_Homo sapiens_hsa041521.11953958
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11217795
64Acute myeloid leukemia_Homo sapiens_hsa052211.11191475
65Graft-versus-host disease_Homo sapiens_hsa053321.11126574
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07137073
67Tyrosine metabolism_Homo sapiens_hsa003501.06653894
68Notch signaling pathway_Homo sapiens_hsa043301.03046757
69Insulin signaling pathway_Homo sapiens_hsa049101.02462978
70Bile secretion_Homo sapiens_hsa049760.99230014
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98988202
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.98392347
73Collecting duct acid secretion_Homo sapiens_hsa049660.97730537
74Autoimmune thyroid disease_Homo sapiens_hsa053200.93106494
75Chemokine signaling pathway_Homo sapiens_hsa040620.93073463
76Chemical carcinogenesis_Homo sapiens_hsa052040.92586653
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91676860
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91354369
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91042395
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89360108
81Influenza A_Homo sapiens_hsa051640.88250297
82Sulfur metabolism_Homo sapiens_hsa009200.85428602
83Asthma_Homo sapiens_hsa053100.83755901
84Viral myocarditis_Homo sapiens_hsa054160.83345107
85Histidine metabolism_Homo sapiens_hsa003400.83268718
86Biosynthesis of amino acids_Homo sapiens_hsa012300.82527333
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.81493024
88Hematopoietic cell lineage_Homo sapiens_hsa046400.81357133
89T cell receptor signaling pathway_Homo sapiens_hsa046600.81162229
90Fructose and mannose metabolism_Homo sapiens_hsa000510.81114169
91Pentose phosphate pathway_Homo sapiens_hsa000300.79244852
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78955371
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.78297497
94Glucagon signaling pathway_Homo sapiens_hsa049220.77984791
95Hepatitis C_Homo sapiens_hsa051600.77142022
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76925274
97Renal cell carcinoma_Homo sapiens_hsa052110.76675016
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76378456
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75803620
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.70341641
101Shigellosis_Homo sapiens_hsa051310.69295979
102GnRH signaling pathway_Homo sapiens_hsa049120.65864323
103Vitamin B6 metabolism_Homo sapiens_hsa007500.64700856
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.64290694
105Measles_Homo sapiens_hsa051620.63976739
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.63607649
107Retinol metabolism_Homo sapiens_hsa008300.63553830
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63420182
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63327479
110Type II diabetes mellitus_Homo sapiens_hsa049300.62118358
111Amoebiasis_Homo sapiens_hsa051460.61173740
112VEGF signaling pathway_Homo sapiens_hsa043700.60551849
113Type I diabetes mellitus_Homo sapiens_hsa049400.60060089
114Estrogen signaling pathway_Homo sapiens_hsa049150.60032288
115Endocytosis_Homo sapiens_hsa041440.58981710
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.58783080
117Hepatitis B_Homo sapiens_hsa051610.57128246
118Non-small cell lung cancer_Homo sapiens_hsa052230.56953361
119Vibrio cholerae infection_Homo sapiens_hsa051100.55943947
120Sphingolipid metabolism_Homo sapiens_hsa006000.55813871
121Galactose metabolism_Homo sapiens_hsa000520.55728036
122Dorso-ventral axis formation_Homo sapiens_hsa043200.55133354
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53856777
124Apoptosis_Homo sapiens_hsa042100.53770573
125Pancreatic cancer_Homo sapiens_hsa052120.53160426
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.52071844
127Platelet activation_Homo sapiens_hsa046110.51768046
128Bladder cancer_Homo sapiens_hsa052190.51389799
129Mineral absorption_Homo sapiens_hsa049780.50898361
130Chronic myeloid leukemia_Homo sapiens_hsa052200.50775152
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47446599
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.47116368
133African trypanosomiasis_Homo sapiens_hsa051430.46808874
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45593127
135Prolactin signaling pathway_Homo sapiens_hsa049170.44995095
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.44471004
137Renin secretion_Homo sapiens_hsa049240.44314949
138Herpes simplex infection_Homo sapiens_hsa051680.44219935
139Endometrial cancer_Homo sapiens_hsa052130.43873097
140Sulfur relay system_Homo sapiens_hsa041220.40211601
141FoxO signaling pathway_Homo sapiens_hsa040680.39005714
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38827404
143Choline metabolism in cancer_Homo sapiens_hsa052310.38433629
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38284332
145Lysosome_Homo sapiens_hsa041420.36157175
146mTOR signaling pathway_Homo sapiens_hsa041500.35023070
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33578876
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32967935
149Cardiac muscle contraction_Homo sapiens_hsa042600.32353796
150Steroid biosynthesis_Homo sapiens_hsa001000.30848432
151Folate biosynthesis_Homo sapiens_hsa007900.30323580
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.30001456
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.29659157
154Prion diseases_Homo sapiens_hsa050200.28792679
155Pertussis_Homo sapiens_hsa051330.27466327
156Metabolic pathways_Homo sapiens_hsa011000.27160976
157Arginine and proline metabolism_Homo sapiens_hsa003300.26271572
158Lysine degradation_Homo sapiens_hsa003100.25546346
159Selenocompound metabolism_Homo sapiens_hsa004500.24896331
160Vitamin digestion and absorption_Homo sapiens_hsa049770.22424081
161Renin-angiotensin system_Homo sapiens_hsa046140.22055951
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21762196
163Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20176944
164Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20100111
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19822500
166Alzheimers disease_Homo sapiens_hsa050100.16675592
167cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15863013
168Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15671752
169Oxidative phosphorylation_Homo sapiens_hsa001900.15544120
170Parkinsons disease_Homo sapiens_hsa050120.13787330
171Dilated cardiomyopathy_Homo sapiens_hsa054140.13591483
172HIF-1 signaling pathway_Homo sapiens_hsa040660.12185908
173Glycosaminoglycan degradation_Homo sapiens_hsa005310.11038888
174Glutathione metabolism_Homo sapiens_hsa004800.10708591
175Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09328848
176Phagosome_Homo sapiens_hsa041450.08769389

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »