EFCAB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.40962673
2Golgi transport vesicle coating (GO:0048200)8.94812164
3COPI coating of Golgi vesicle (GO:0048205)8.94812164
4regulation of cilium movement (GO:0003352)8.30905334
5left/right axis specification (GO:0070986)7.30282320
6ventricular system development (GO:0021591)7.29077347
7primary alcohol catabolic process (GO:0034310)7.10874109
8endocrine pancreas development (GO:0031018)6.93298057
9microtubule bundle formation (GO:0001578)6.51719068
10vitamin transmembrane transport (GO:0035461)6.44919123
11cilium organization (GO:0044782)6.30617295
12signal peptide processing (GO:0006465)6.21360744
13peptide hormone processing (GO:0016486)6.17998834
14cilium assembly (GO:0042384)6.10205094
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.95863673
16ethanol metabolic process (GO:0006067)5.93880133
17protein maturation by protein folding (GO:0022417)5.92497076
18diterpenoid biosynthetic process (GO:0016102)5.63955511
19COPII vesicle coating (GO:0048208)5.56201372
20glandular epithelial cell differentiation (GO:0002067)5.51723235
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.38144046
22protein retention in ER lumen (GO:0006621)5.18262159
23positive regulation of insulin secretion (GO:0032024)5.14087908
24centriole assembly (GO:0098534)5.13520237
25regulation of type B pancreatic cell apoptotic process (GO:2000674)5.10066206
26ER overload response (GO:0006983)5.07869289
27response to xenobiotic stimulus (GO:0009410)5.05910437
28protein localization to cilium (GO:0061512)5.04154384
29pyrimidine-containing compound transmembrane transport (GO:0072531)5.03943626
30sequestering of metal ion (GO:0051238)5.03859863
31microtubule-based movement (GO:0007018)4.99571534
32insulin secretion (GO:0030073)4.97152637
33lung epithelium development (GO:0060428)4.93547021
34cellular component assembly involved in morphogenesis (GO:0010927)4.83448318
35regulation of microtubule-based movement (GO:0060632)4.82368351
36tolerance induction (GO:0002507)4.78304010
37one-carbon compound transport (GO:0019755)4.66438666
38sperm capacitation (GO:0048240)4.58590624
39cilium morphogenesis (GO:0060271)4.55002297
40regulation of insulin secretion (GO:0050796)4.53897538
41negative regulation of T cell differentiation in thymus (GO:0033085)4.46567493
42ethanol oxidation (GO:0006069)4.45007976
43regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.44802457
44regulation of interleukin-5 production (GO:0032674)4.44442331
45intraciliary transport (GO:0042073)4.42976122
46establishment of apical/basal cell polarity (GO:0035089)4.41710065
47glomerular epithelial cell development (GO:0072310)4.40610583
48cell projection assembly (GO:0030031)4.40413112
49detection of calcium ion (GO:0005513)4.39528041
50negative regulation of B cell mediated immunity (GO:0002713)4.35535388
51negative regulation of immunoglobulin mediated immune response (GO:0002890)4.35535388
52type B pancreatic cell development (GO:0003323)4.35215681
53negative regulation of humoral immune response (GO:0002921)4.17301514
54positive regulation of peptide hormone secretion (GO:0090277)4.15809528
55nucleoside diphosphate phosphorylation (GO:0006165)4.15028084
56regulation of peptide hormone secretion (GO:0090276)4.13592309
57glandular epithelial cell development (GO:0002068)4.12496657
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.10380914
59intra-Golgi vesicle-mediated transport (GO:0006891)4.09291409
60regulation of peptide secretion (GO:0002791)4.06283244
61positive regulation of peptide secretion (GO:0002793)4.03095670
62regulation of interleukin-13 production (GO:0032656)3.97083966
63axoneme assembly (GO:0035082)3.96761384
64vesicle coating (GO:0006901)3.96522380
65terpenoid biosynthetic process (GO:0016114)3.95544835
66retinoic acid metabolic process (GO:0042573)3.94896921
67positive regulation of tolerance induction (GO:0002645)3.92802686
68regulation of germinal center formation (GO:0002634)3.92710458
69lateral ventricle development (GO:0021670)3.91224363
70establishment or maintenance of monopolar cell polarity (GO:0061339)3.87069247
71establishment of monopolar cell polarity (GO:0061162)3.87069247
72regulation of glucocorticoid secretion (GO:2000849)3.82497285
73activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.82188696
74protein localization to Golgi apparatus (GO:0034067)3.79918084
75exocrine pancreas development (GO:0031017)3.79374783
76peptide hormone secretion (GO:0030072)3.78798636
77microtubule depolymerization (GO:0007019)3.74176364
78cytoplasmic microtubule organization (GO:0031122)3.71314344
79regulation of hormone secretion (GO:0046883)3.68822629
80peptide secretion (GO:0002790)3.68503994
81toxin metabolic process (GO:0009404)3.65895531
82cilium movement (GO:0003341)3.62451129
83positive regulation of nuclease activity (GO:0032075)3.57969027
84negative regulation of inclusion body assembly (GO:0090084)3.57237455
85negative regulation of insulin secretion (GO:0046676)3.55164716
86ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.52827610
87axonemal dynein complex assembly (GO:0070286)3.47988289
88establishment of tissue polarity (GO:0007164)3.47865987
89establishment of planar polarity (GO:0001736)3.47865987
90microtubule polymerization or depolymerization (GO:0031109)3.46818264
91regulation of glucokinase activity (GO:0033131)3.46396054
92regulation of hexokinase activity (GO:1903299)3.46396054
93positive regulation of hormone secretion (GO:0046887)3.41187703
94columnar/cuboidal epithelial cell development (GO:0002066)3.37428622
95regulation of corticosteroid hormone secretion (GO:2000846)3.32617972
96exogenous drug catabolic process (GO:0042738)3.32559394
97regulation of peptide transport (GO:0090087)3.31716635
98determination of left/right symmetry (GO:0007368)3.30062248
99nitric oxide mediated signal transduction (GO:0007263)3.28415186
100cellular zinc ion homeostasis (GO:0006882)3.27060540
101positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.26308156
102ER to Golgi vesicle-mediated transport (GO:0006888)3.24359358
103regulation of nuclease activity (GO:0032069)3.23593712
104positive regulation of smoothened signaling pathway (GO:0045880)3.21978746
105positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19289538
106cellular response to unfolded protein (GO:0034620)3.18486423
107epithelial cell fate commitment (GO:0072148)3.17958455
108regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.17730360
109determination of bilateral symmetry (GO:0009855)3.17248370
110negative regulation of glycoprotein biosynthetic process (GO:0010561)3.17215137
111glutathione derivative biosynthetic process (GO:1901687)3.16529826
112glutathione derivative metabolic process (GO:1901685)3.16529826
113primary alcohol metabolic process (GO:0034308)3.15864515
114endoplasmic reticulum unfolded protein response (GO:0030968)3.15057405
115negative regulation of catecholamine secretion (GO:0033604)3.14856889
116cellular response to topologically incorrect protein (GO:0035967)3.14446397
117positive regulation of vesicle fusion (GO:0031340)3.13810542
118inner ear receptor cell development (GO:0060119)3.11756972
119specification of symmetry (GO:0009799)3.11480625
120negative regulation of peptide hormone secretion (GO:0090278)3.11206942
121negative regulation of norepinephrine secretion (GO:0010700)3.08056048
122retinol metabolic process (GO:0042572)3.07096618
123regulation of oxidative phosphorylation (GO:0002082)3.06609511
124centriole replication (GO:0007099)3.05769483
125O-glycan processing (GO:0016266)3.05098703
126hormone secretion (GO:0046879)3.04329191
127sperm motility (GO:0030317)3.02786532
128protein N-linked glycosylation via asparagine (GO:0018279)3.02529668
129ER-nucleus signaling pathway (GO:0006984)3.00855496
130cellular response to vitamin D (GO:0071305)2.99792155
131negative regulation of peptide secretion (GO:0002792)2.98774534
132astrocyte differentiation (GO:0048708)2.98555338
133peptidyl-asparagine modification (GO:0018196)2.98551872
134smoothened signaling pathway (GO:0007224)2.97859692
135lateral sprouting from an epithelium (GO:0060601)2.97542994
136protein targeting to Golgi (GO:0000042)2.94669608
137peptide transport (GO:0015833)2.91604317
138hormone transport (GO:0009914)2.91284841
139regulation of tolerance induction (GO:0002643)2.90162226
140growth hormone secretion (GO:0030252)2.89832648
141negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.89453074
142microtubule-based process (GO:0007017)2.88902619
143hydrogen peroxide biosynthetic process (GO:0050665)2.88599841
144regulation of calcium ion-dependent exocytosis (GO:0017158)2.88593948
145apical protein localization (GO:0045176)2.87959162
146negative regulation of JUN kinase activity (GO:0043508)2.87940915
147aldehyde catabolic process (GO:0046185)2.86960268
148retinal rod cell development (GO:0046548)2.85092751
149regulation of microtubule depolymerization (GO:0031114)2.82287473
1503-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.82043568
151purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.82043568
152cellular response to glucagon stimulus (GO:0071377)2.80644461
153macroautophagy (GO:0016236)2.80204935
154protein N-linked glycosylation (GO:0006487)2.76193690
155neuron fate specification (GO:0048665)2.74874937
156regulation of autophagic vacuole assembly (GO:2000785)2.74749587
157pancreas development (GO:0031016)2.74217556
158Golgi organization (GO:0007030)2.73148471
159carnitine metabolic process (GO:0009437)2.72979381
160response to endoplasmic reticulum stress (GO:0034976)2.72738854
161interleukin-1-mediated signaling pathway (GO:0070498)2.70070104
162response to hexose (GO:0009746)2.69831918
163phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69397188
164organelle assembly (GO:0070925)2.68827731
165catechol-containing compound biosynthetic process (GO:0009713)2.68578682
166catecholamine biosynthetic process (GO:0042423)2.68578682
167dopamine biosynthetic process (GO:0042416)2.67930748
168negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.67476072
169Golgi vesicle transport (GO:0048193)2.66475213
170regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.66090911
171multicellular organismal water homeostasis (GO:0050891)2.65555982
172response to glucose (GO:0009749)2.65147705
173negative regulation of bone resorption (GO:0045779)2.64900349
174magnesium ion transport (GO:0015693)2.63927881
175heart looping (GO:0001947)2.59686676
176reactive oxygen species biosynthetic process (GO:1903409)2.59529332
177drug catabolic process (GO:0042737)2.56620101
178excretion (GO:0007588)2.51921585
179progesterone metabolic process (GO:0042448)2.48181657
180phosphatidylcholine biosynthetic process (GO:0006656)2.43792456
181hydrogen peroxide catabolic process (GO:0042744)2.43690207
182dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.40011715
183calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.35875227
184embryonic heart tube morphogenesis (GO:0003143)2.35548786
185hypotonic response (GO:0006971)2.33331311
186regulation of response to osmotic stress (GO:0047484)2.32829132
187photoreceptor cell maintenance (GO:0045494)2.32804237
188regulation of collateral sprouting (GO:0048670)2.31451952
189regulation of smoothened signaling pathway (GO:0008589)2.31098043
190regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.30752326
191nonmotile primary cilium assembly (GO:0035058)2.30623849
192cilium or flagellum-dependent cell motility (GO:0001539)19.1416081
193motile cilium assembly (GO:0044458)15.4778674
194epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.2701532
195epithelial cilium movement (GO:0003351)14.5384164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.43992887
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.14154131
3* DROSHA_22980978_ChIP-Seq_HELA_Human3.23932633
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.12022677
5DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.07649893
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.81052620
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.56224637
8EZH2_22144423_ChIP-Seq_EOC_Human2.49828181
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47876163
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20462591
11GBX2_23144817_ChIP-Seq_PC3_Human2.19733298
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18948103
13GATA1_22025678_ChIP-Seq_K562_Human2.17667769
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17343746
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.11114304
16IGF1R_20145208_ChIP-Seq_DFB_Human2.08580683
17REST_21632747_ChIP-Seq_MESCs_Mouse2.02051080
18AHR_22903824_ChIP-Seq_MCF-7_Human2.00645772
19VDR_22108803_ChIP-Seq_LS180_Human1.90026189
20PIAS1_25552417_ChIP-Seq_VCAP_Human1.80563699
21FOXM1_26456572_ChIP-Seq_MCF-7_Human1.79560391
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.79043639
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78874335
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77463584
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76221400
26STAT1_20625510_ChIP-Seq_HELA_Human1.73135741
27NR3C1_23031785_ChIP-Seq_PC12_Mouse1.72569737
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70484247
29* RUNX1_27514584_Chip-Seq_MCF-7_Human1.69489793
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.69091512
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.68932265
32SMC4_20622854_ChIP-Seq_HELA_Human1.68895000
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68632588
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.68463238
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.66687327
36ZNF274_21170338_ChIP-Seq_K562_Hela1.66557081
37* TP63_23658742_ChIP-Seq_EP156T_Human1.63783961
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57986218
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55397005
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.54371637
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.54157693
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.53160335
43REST_19997604_ChIP-ChIP_NEURONS_Mouse1.52262327
44CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50621112
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.50249534
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48250057
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47903288
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47198652
49* STAT3_23295773_ChIP-Seq_U87_Human1.46760801
50* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.45774478
51ETV1_20927104_ChIP-Seq_GIST48_Human1.45087127
52TP53_18474530_ChIP-ChIP_U2OS_Human1.44015739
53P300_19829295_ChIP-Seq_ESCs_Human1.42842890
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.42236550
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.40665720
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40013967
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39643648
58* TP63_22573176_ChIP-Seq_HFKS_Human1.39432306
59* KLF5_25053715_ChIP-Seq_YYC3_Human1.39308153
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39106251
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39014347
62RAD21_21589869_ChIP-Seq_MESCs_Mouse1.38962908
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38729525
64PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.37212050
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37191515
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36505162
67SOX2_20726797_ChIP-Seq_SW620_Human1.34750129
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34535945
69PHF8_20622853_ChIP-Seq_HELA_Human1.34292237
70SMRT_27268052_Chip-Seq_Bcells_Human1.34015776
71EZH2_27294783_Chip-Seq_ESCs_Mouse1.33658960
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32947997
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.32537004
74HNFA_21074721_ChIP-Seq_CACO-2_Human1.32079619
75* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31776333
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.31717619
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.30248091
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30018398
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28713432
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28614921
81* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28460851
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27997227
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27873318
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27199813
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25751337
86RNF2_27304074_Chip-Seq_NSC_Mouse1.24694317
87* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23677169
88SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.22411686
89GATA1_19941826_ChIP-Seq_K562_Human1.21172205
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21017692
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.20423491
92P53_22387025_ChIP-Seq_ESCs_Mouse1.20382218
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.19295396
94RBPJ_21746931_ChIP-Seq_IB4_Human1.18188483
95* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17903197
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17370740
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15540080
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14733781
99NFYA_21822215_ChIP-Seq_K562_Human1.13616816
100CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13153451
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12975141
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12706862
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12613094
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12323277
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11763335
106GATA4_25053715_ChIP-Seq_YYC3_Human1.10723816
107* RUNX2_22187159_ChIP-Seq_PCA_Human1.10001426
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.09815081
109NMYC_18555785_Chip-Seq_ESCs_Mouse1.09437206
110GATA6_21074721_ChIP-Seq_CACO-2_Human1.09105997
111* SOX2_21211035_ChIP-Seq_LN229_Gbm1.08628554
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08495305
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.07989688
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.07841064
115TCF4_23295773_ChIP-Seq_U87_Human1.07638293
116GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06737456
117CTCF_27219007_Chip-Seq_Bcells_Human1.06612393
118* FLI1_21867929_ChIP-Seq_TH2_Mouse1.06461835
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06434312
120CTCF_20526341_ChIP-Seq_ESCs_Human1.06412203
121NFYB_21822215_ChIP-Seq_K562_Human1.06249232
122TBL1_22424771_ChIP-Seq_293T_Human1.05921226
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04869086
124TP53_22573176_ChIP-Seq_HFKS_Human1.04553048
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.04429896
126BCAT_22108803_ChIP-Seq_LS180_Human1.04390088
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04208551
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04015912
129MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03658883
130CEBPB_22108803_ChIP-Seq_LS180_Human1.02179955
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01186050
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.01165280
133* SMAD3_21741376_ChIP-Seq_ESCs_Human1.01082213
134* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00817569
135GATA3_24758297_ChIP-Seq_MCF-7_Human1.00330449
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.99840729
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.99361310
138GABP_17652178_ChIP-ChIP_JURKAT_Human0.99315740
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.99284945
140AR_21572438_ChIP-Seq_LNCaP_Human0.99240506
141SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98848897
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.96884748
143PHF8_20622854_ChIP-Seq_HELA_Human0.96325678
144* SMAD3_21741376_ChIP-Seq_EPCs_Human0.96241063
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96228634
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.96228634
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95848282
148P68_20966046_ChIP-Seq_HELA_Human0.95283243
149WDR5_24793694_ChIP-Seq_LNCAP_Human0.94888160
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94816090
151JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94461269
152TCF4_22108803_ChIP-Seq_LS180_Human0.93702051
153* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93640747
154E2F1_18555785_Chip-Seq_ESCs_Mouse0.93632985
155FUS_26573619_Chip-Seq_HEK293_Human0.92884871
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91380344
157KLF4_18555785_Chip-Seq_ESCs_Mouse0.91163908
158ZFX_18555785_Chip-Seq_ESCs_Mouse0.90404574
159ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90337534
160CREB1_26743006_Chip-Seq_LNCaP_Human0.90152748
161P300_18555785_Chip-Seq_ESCs_Mouse0.89846357
162TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89770669
163ELF1_17652178_ChIP-ChIP_JURKAT_Human0.89717728
164TP53_16413492_ChIP-PET_HCT116_Human0.89602606
165FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89333714
166TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88625349
167EZH2_27294783_Chip-Seq_NPCs_Mouse0.88541380
168ESRRB_18555785_Chip-Seq_ESCs_Mouse0.88412183
169BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88051748
170P300_27268052_Chip-Seq_Bcells_Human0.87423325
171GF1B_26923725_Chip-Seq_HPCs_Mouse0.87363022
172CBX2_27304074_Chip-Seq_ESCs_Mouse0.87360425
173SOX2_21211035_ChIP-Seq_LN229_Human0.87211841
174SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86415455
175EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83978332
176CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83681447
177FLI1_21867929_ChIP-Seq_CD8_Mouse0.83396518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.70558996
2MP0002132_abnormal_respiratory_system5.46211346
3MP0002877_abnormal_melanocyte_morpholog4.13969100
4MP0003183_abnormal_peptide_metabolism4.13904488
5MP0000013_abnormal_adipose_tissue4.13329330
6MP0010386_abnormal_urinary_bladder4.09667775
7MP0009780_abnormal_chondrocyte_physiolo4.07170123
8MP0002909_abnormal_adrenal_gland3.89098050
9MP0005379_endocrine/exocrine_gland_phen3.88879417
10MP0002693_abnormal_pancreas_physiology3.76572599
11MP0005623_abnormal_meninges_morphology3.75904762
12MP0004043_abnormal_pH_regulation3.68814096
13MP0002277_abnormal_respiratory_mucosa3.64371524
14MP0001944_abnormal_pancreas_morphology3.54868938
15MP0003283_abnormal_digestive_organ3.53035862
16MP0000566_synostosis3.41967417
17MP0008789_abnormal_olfactory_epithelium3.33872831
18MP0002837_dystrophic_cardiac_calcinosis2.84099034
19MP0006072_abnormal_retinal_apoptosis2.83603876
20MP0003195_calcinosis2.79530311
21MP0005646_abnormal_pituitary_gland2.64926994
22MP0005220_abnormal_exocrine_pancreas2.55465127
23MP0000383_abnormal_hair_follicle2.49180109
24MP0000678_abnormal_parathyroid_gland2.48755913
25MP0003122_maternal_imprinting2.45364234
26MP0005645_abnormal_hypothalamus_physiol2.40004130
27MP0002282_abnormal_trachea_morphology2.39386190
28MP0005394_taste/olfaction_phenotype2.25372541
29MP0005499_abnormal_olfactory_system2.25372541
30MP0005377_hearing/vestibular/ear_phenot2.13398754
31MP0003878_abnormal_ear_physiology2.13398754
32MP0002638_abnormal_pupillary_reflex2.09931951
33MP0004019_abnormal_vitamin_homeostasis2.08492828
34MP0010678_abnormal_skin_adnexa2.07212176
35MP0002078_abnormal_glucose_homeostasis2.05094381
36MP0002168_other_aberrant_phenotype1.89971846
37MP0004270_analgesia1.86487422
38MP0001346_abnormal_lacrimal_gland1.82034787
39MP0000003_abnormal_adipose_tissue1.81229526
40MP0002160_abnormal_reproductive_system1.80547019
41MP0003656_abnormal_erythrocyte_physiolo1.80528274
42MP0002163_abnormal_gland_morphology1.71624351
43MP0005083_abnormal_biliary_tract1.68325420
44MP0001986_abnormal_taste_sensitivity1.68078669
45MP0002234_abnormal_pharynx_morphology1.59845531
46MP0004264_abnormal_extraembryonic_tissu1.51374084
47MP0000631_abnormal_neuroendocrine_gland1.50634011
48MP0010030_abnormal_orbit_morphology1.49299640
49MP0001765_abnormal_ion_homeostasis1.46392480
50MP0002928_abnormal_bile_duct1.42343571
51MP0005248_abnormal_Harderian_gland1.40424557
52MP0002249_abnormal_larynx_morphology1.39715541
53MP0001502_abnormal_circadian_rhythm1.39094753
54MP0006276_abnormal_autonomic_nervous1.35755093
55MP0002876_abnormal_thyroid_physiology1.33529530
56MP0003953_abnormal_hormone_level1.33401602
57MP0002896_abnormal_bone_mineralization1.30697909
58MP0003172_abnormal_lysosome_physiology1.29088216
59MP0002734_abnormal_mechanical_nocicepti1.28990083
60MP0000462_abnormal_digestive_system1.27733217
61MP0000613_abnormal_salivary_gland1.24054691
62MP0002233_abnormal_nose_morphology1.23074053
63MP0000538_abnormal_urinary_bladder1.22022943
64MP0006292_abnormal_olfactory_placode1.20536318
65MP0005253_abnormal_eye_physiology1.19139603
66MP0005535_abnormal_body_temperature1.18033893
67MP0005395_other_phenotype1.16102760
68MP0003890_abnormal_embryonic-extraembry1.14876864
69MP0002938_white_spotting1.11909475
70MP0005165_increased_susceptibility_to1.09404233
71MP0008961_abnormal_basal_metabolism1.08302652
72MP0001756_abnormal_urination1.05412760
73MP0002751_abnormal_autonomic_nervous1.04390361
74MP0002138_abnormal_hepatobiliary_system1.04138646
75MP0003959_abnormal_lean_body1.04079986
76MP0010155_abnormal_intestine_physiology1.03255801
77MP0009379_abnormal_foot_pigmentation1.03173301
78MP0003868_abnormal_feces_composition1.00959893
79MP0005636_abnormal_mineral_homeostasis0.99153703
80MP0002733_abnormal_thermal_nociception0.97983524
81MP0005257_abnormal_intraocular_pressure0.97555924
82MP0001984_abnormal_olfaction0.95106769
83MP0000465_gastrointestinal_hemorrhage0.93572694
84MP0002653_abnormal_ependyma_morphology0.92830130
85MP0001485_abnormal_pinna_reflex0.92572131
86MP0002735_abnormal_chemical_nociception0.91388097
87MP0002557_abnormal_social/conspecific_i0.90934790
88MP0009046_muscle_twitch0.89363711
89MP0005448_abnormal_energy_balance0.87325010
90MP0003787_abnormal_imprinting0.87228733
91MP0003303_peritoneal_inflammation0.87178319
92MP0001270_distended_abdomen0.86970290
93MP0001299_abnormal_eye_distance/0.86343203
94MP0010234_abnormal_vibrissa_follicle0.85579391
95MP0009643_abnormal_urine_homeostasis0.85088835
96MP0003879_abnormal_hair_cell0.84063295
97MP0001293_anophthalmia0.82494561
98MP0001849_ear_inflammation0.82244085
99MP0005164_abnormal_response_to0.81932049
100MP0002572_abnormal_emotion/affect_behav0.81768046
101MP0005058_abnormal_lysosome_morphology0.80644546
102MP0005389_reproductive_system_phenotype0.79531869
103MP0004883_abnormal_blood_vessel0.79414726
104MP0003136_yellow_coat_color0.79387895
105MP0001970_abnormal_pain_threshold0.79087664
106MP0005310_abnormal_salivary_gland0.78811463
107MP0003635_abnormal_synaptic_transmissio0.78354055
108MP0003698_abnormal_male_reproductive0.77680969
109MP0003119_abnormal_digestive_system0.77606168
110MP0005084_abnormal_gallbladder_morpholo0.77316533
111MP0001188_hyperpigmentation0.76030420
112MP0000230_abnormal_systemic_arterial0.75751146
113MP0000026_abnormal_inner_ear0.75668629
114MP0001929_abnormal_gametogenesis0.74648900
115MP0002069_abnormal_eating/drinking_beha0.71825205
116MP0002272_abnormal_nervous_system0.71271148
117MP0000681_abnormal_thyroid_gland0.70918751
118MP0003937_abnormal_limbs/digits/tail_de0.70913897
119MP0002098_abnormal_vibrissa_morphology0.69851527
120MP0002136_abnormal_kidney_physiology0.68865922
121MP0003938_abnormal_ear_development0.68702090
122MP0005375_adipose_tissue_phenotype0.68446796
123MP0002177_abnormal_outer_ear0.67778972
124MP0003121_genomic_imprinting0.67503927
125MP0001664_abnormal_digestion0.67460188
126MP0009765_abnormal_xenobiotic_induced0.66826334
127MP0004133_heterotaxia0.66715178
128MP0005503_abnormal_tendon_morphology0.66468231
129MP0001324_abnormal_eye_pigmentation0.65573850
130MP0000955_abnormal_spinal_cord0.65446575
131MP0002184_abnormal_innervation0.63881540
132MP0002405_respiratory_system_inflammati0.62885570
133MP0001501_abnormal_sleep_pattern0.62545806
134MP0004085_abnormal_heartbeat0.62306446
135MP0005085_abnormal_gallbladder_physiolo0.61675319
136MP0002063_abnormal_learning/memory/cond0.61638167
137MP0002116_abnormal_craniofacial_bone0.60786779
138MP0000467_abnormal_esophagus_morphology0.60434129
139MP0000639_abnormal_adrenal_gland0.58727323
140MP0003806_abnormal_nucleotide_metabolis0.57573142
141MP0003453_abnormal_keratinocyte_physiol0.56291667
142MP0000163_abnormal_cartilage_morphology0.56031646
143MP0009703_decreased_birth_body0.55988214
144MP0005452_abnormal_adipose_tissue0.55888524
145MP0002133_abnormal_respiratory_system0.55723599
146MP0005388_respiratory_system_phenotype0.55723599
147MP0004145_abnormal_muscle_electrophysio0.55405400
148MP0001186_pigmentation_phenotype0.54919831
149MP0005408_hypopigmentation0.54557341
150MP0001919_abnormal_reproductive_system0.54365045
151MP0005551_abnormal_eye_electrophysiolog0.53803462
152MP0005670_abnormal_white_adipose0.53648053
153MP0006082_CNS_inflammation0.53250350
154MP0000049_abnormal_middle_ear0.52834057
155MP0002139_abnormal_hepatobiliary_system0.52494742
156MP0006054_spinal_hemorrhage0.52178154
157MP0005365_abnormal_bile_salt0.50750338
158MP0005391_vision/eye_phenotype0.50512388
159MP0003633_abnormal_nervous_system0.50044896
160MP0001879_abnormal_lymphatic_vessel0.49601406
161MP0009763_increased_sensitivity_to0.49338867
162MP0001529_abnormal_vocalization0.49209638
163MP0002084_abnormal_developmental_patter0.49113355
164MP0003634_abnormal_glial_cell0.48748791
165MP0005195_abnormal_posterior_eye0.48142055
166MP0001963_abnormal_hearing_physiology0.47381952
167MP0003861_abnormal_nervous_system0.44269657
168MP0002229_neurodegeneration0.43610783
169MP0001663_abnormal_digestive_system0.42989372

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.22691024
2Nasal polyposis (HP:0100582)6.76465323
3Hypoglycemic seizures (HP:0002173)6.73993932
4Symptomatic seizures (HP:0011145)5.96730130
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.80392289
6Abnormality of the nasal mucosa (HP:0000433)5.62778414
7Hypoglycemic coma (HP:0001325)5.43192537
8Hyperglycemia (HP:0003074)4.69607243
9Recurrent sinusitis (HP:0011108)4.38994438
10Bronchitis (HP:0012387)4.36531781
11Chronic sinusitis (HP:0011109)4.19954048
12Abnormality of calcium-phosphate metabolism (HP:0100530)4.18902215
13Infertility (HP:0000789)4.17587462
14Insulin-resistant diabetes mellitus (HP:0000831)4.09624574
15Abnormality of endocrine pancreas physiology (HP:0012093)4.01995182
16Abnormality of the pancreatic islet cells (HP:0006476)4.01995182
17Ketoacidosis (HP:0001993)3.92227456
18Abnormal ciliary motility (HP:0012262)3.90102270
19Abnormal respiratory motile cilium physiology (HP:0012261)3.88981286
20Recurrent otitis media (HP:0000403)3.87755889
21Pancreatic islet-cell hyperplasia (HP:0004510)3.86087062
22Chronic bronchitis (HP:0004469)3.84787295
23Male infertility (HP:0003251)3.73885864
24Large for gestational age (HP:0001520)3.73375677
25Late onset (HP:0003584)3.61648586
26Abnormal pancreas size (HP:0012094)3.59637269
27Decreased circulating renin level (HP:0003351)3.43789994
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.43416345
29Hypothermia (HP:0002045)3.41652872
30Rhinitis (HP:0012384)3.34310820
31Abnormality of the fovea (HP:0000493)3.15667978
32Chronic otitis media (HP:0000389)3.10401188
33Atelectasis (HP:0100750)2.96349550
34Dysostosis multiplex (HP:0000943)2.95346213
35Agitation (HP:0000713)2.94364108
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.89757617
37Hypoplasia of the fovea (HP:0007750)2.89757617
38Osteomalacia (HP:0002749)2.88458631
39Nephronophthisis (HP:0000090)2.83973186
40Hypokalemia (HP:0002900)2.82643622
41True hermaphroditism (HP:0010459)2.81662013
42Pancreatic fibrosis (HP:0100732)2.80249843
43Urinary glycosaminoglycan excretion (HP:0003541)2.68336050
44Mucopolysacchariduria (HP:0008155)2.68336050
45Conjugated hyperbilirubinemia (HP:0002908)2.66217493
46Abnormality of midbrain morphology (HP:0002418)2.65443762
47Molar tooth sign on MRI (HP:0002419)2.65443762
48Intestinal atresia (HP:0011100)2.65281942
49Retinal atrophy (HP:0001105)2.63465093
50Medial flaring of the eyebrow (HP:0010747)2.62129237
51Cystic liver disease (HP:0006706)2.57830823
52Chronic hepatic failure (HP:0100626)2.56486179
53Bifid tongue (HP:0010297)2.56365871
54Generalized aminoaciduria (HP:0002909)2.54554401
55Postaxial foot polydactyly (HP:0001830)2.51047055
56EEG with generalized epileptiform discharges (HP:0011198)2.49242935
57Hyperkalemia (HP:0002153)2.44277034
58Pancreatic cysts (HP:0001737)2.44050825
59Abnormality of polysaccharide metabolism (HP:0011012)2.41375012
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41375012
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41375012
62Epileptiform EEG discharges (HP:0011182)2.41213088
63Hypsarrhythmia (HP:0002521)2.39933915
64Abnormality of potassium homeostasis (HP:0011042)2.39339585
65Congenital primary aphakia (HP:0007707)2.38595490
66Gait imbalance (HP:0002141)2.34719237
67Prominent metopic ridge (HP:0005487)2.33576219
68Dysautonomia (HP:0002459)2.32896813
69Abnormality of renin-angiotensin system (HP:0000847)2.31438555
70Abnormal respiratory motile cilium morphology (HP:0005938)2.30901906
71Abnormal respiratory epithelium morphology (HP:0012253)2.30901906
72Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27163715
73Hyperparathyroidism (HP:0000843)2.27137135
74Insulin resistance (HP:0000855)2.26888683
75Abnormality of the intrinsic pathway (HP:0010989)2.25719209
76Tubulointerstitial nephritis (HP:0001970)2.25208987
77Thoracolumbar scoliosis (HP:0002944)2.20732654
78Bronchiectasis (HP:0002110)2.20282590
79Abnormality of the renal medulla (HP:0100957)2.19185924
80Pheochromocytoma (HP:0002666)2.18362899
81Irregular vertebral endplates (HP:0003301)2.17341357
82Nephrogenic diabetes insipidus (HP:0009806)2.15628578
83Congenital hepatic fibrosis (HP:0002612)2.13966915
84Occipital encephalocele (HP:0002085)2.11071316
85Hyperactive renin-angiotensin system (HP:0000841)2.06309730
86Anencephaly (HP:0002323)2.06022724
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.05686423
88Recurrent bronchitis (HP:0002837)2.03939096
89Abnormality of the metopic suture (HP:0005556)2.03489170
90Bell-shaped thorax (HP:0001591)2.00736575
91Dynein arm defect of respiratory motile cilia (HP:0012255)11.0435695
92Absent/shortened dynein arms (HP:0200106)11.0435695
93Abnormal protein glycosylation (HP:0012346)1.97625474
94Abnormal glycosylation (HP:0012345)1.97625474
95Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97625474
96Abnormal protein N-linked glycosylation (HP:0012347)1.97625474
97Male pseudohermaphroditism (HP:0000037)1.91634454
98Menstrual irregularities (HP:0000858)1.90492843
99Ketosis (HP:0001946)1.90143997
100Absent eyebrow (HP:0002223)1.90023429
101Papilledema (HP:0001085)1.88980757
102Neuroendocrine neoplasm (HP:0100634)1.87836829
103Genital tract atresia (HP:0001827)1.87631097
104Absent frontal sinuses (HP:0002688)1.86617870
105Vaginal atresia (HP:0000148)1.86272502
106Unilateral renal agenesis (HP:0000122)1.85981975
107Hyperphosphatemia (HP:0002905)1.85456139
108Progressive neurologic deterioration (HP:0002344)1.83734285
109Median cleft lip (HP:0000161)1.81631454
110Type I transferrin isoform profile (HP:0003642)1.79939829
111Limb hypertonia (HP:0002509)1.79066182
112Aplasia/Hypoplasia of the lens (HP:0008063)1.78115460
113Anteriorly placed anus (HP:0001545)1.77735984
114Congenital glaucoma (HP:0001087)1.77176272
115Tubular atrophy (HP:0000092)1.76410378
116Papillary thyroid carcinoma (HP:0002895)1.75726792
117Abnormality of the vertebral endplates (HP:0005106)1.75357029
118Sclerocornea (HP:0000647)1.74661408
119Hypotension (HP:0002615)1.74582460
120Renal salt wasting (HP:0000127)1.73547255
121Abdominal distention (HP:0003270)1.73261230
122Disproportionate short-trunk short stature (HP:0003521)1.72517189
123Furrowed tongue (HP:0000221)1.72256583
124Oculomotor apraxia (HP:0000657)1.71739854
125Missing ribs (HP:0000921)1.71614375
126Hyperphosphaturia (HP:0003109)1.71506246
127Flat capital femoral epiphysis (HP:0003370)1.71484541
128Aplasia/Hypoplasia of the macula (HP:0008059)1.70921894
129Tachypnea (HP:0002789)1.70241892
130Asplenia (HP:0001746)1.67353411
131Aplasia/Hypoplasia of the spleen (HP:0010451)1.66151429
132Postaxial hand polydactyly (HP:0001162)1.62579316
133Nephropathy (HP:0000112)1.62548495
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.46792992
135Hyperaldosteronism (HP:0000859)1.43299254
136Preaxial hand polydactyly (HP:0001177)1.40595823
137Tubulointerstitial abnormality (HP:0001969)1.38432271
138Short nail (HP:0001799)1.33276950
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.31934074
140Poor coordination (HP:0002370)1.29136961
141Abnormality of chloride homeostasis (HP:0011422)1.27653614
142Abnormality of the dental root (HP:0006486)1.25365988
143Taurodontia (HP:0000679)1.25365988
144Abnormality of permanent molar morphology (HP:0011071)1.25365988
145Short thorax (HP:0010306)1.23087639
146Cone-rod dystrophy (HP:0000548)1.21906618
147Hypokalemic alkalosis (HP:0001949)1.20640468
148Stage 5 chronic kidney disease (HP:0003774)1.20453770
149Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.17477117
150Abnormality of the frontal sinuses (HP:0002687)1.16789499
151Abnormality of molar morphology (HP:0011070)1.15234445
152Abnormality of molar (HP:0011077)1.15234445
153Decreased central vision (HP:0007663)1.14583504
154Bifid scrotum (HP:0000048)1.13806307
155Glucose intolerance (HP:0000833)1.12526726
156Abnormality of the dental pulp (HP:0006479)1.11761649
157Hyponatremia (HP:0002902)1.10390797
158Polydipsia (HP:0001959)1.09969431
159Abnormal drinking behavior (HP:0030082)1.09969431
160Abnormality of the distal phalanges of the toes (HP:0010182)1.09844259
161Tubulointerstitial fibrosis (HP:0005576)1.08005608
162Abnormality of dentin (HP:0010299)1.07219553
163Hand muscle atrophy (HP:0009130)1.06246114
164Supernumerary spleens (HP:0009799)1.05353209
165Abnormal biliary tract physiology (HP:0012439)1.05303523
166Bile duct proliferation (HP:0001408)1.05303523
167Fetal akinesia sequence (HP:0001989)0.97073791
168Short femoral neck (HP:0100864)0.95533522
169Retinitis pigmentosa (HP:0000510)0.95503853
170Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)0.94577038
171Absent speech (HP:0001344)0.92918527
172Abnormality of the renal cortex (HP:0011035)0.92899064
173Narrow forehead (HP:0000341)0.92399976
174Broad distal phalanx of finger (HP:0009836)0.91253992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.81803440
2MAPK155.69374321
3MST45.63308607
4PRKD34.66631544
5PASK4.09988769
6WNK32.86247087
7MAP3K22.73861545
8NTRK32.69639730
9TAOK32.61817678
10HIPK22.51790117
11FRK2.46764750
12MAPKAPK32.38993261
13WNK42.37848755
14STK242.01716493
15PTK2B1.81401360
16UHMK11.80795525
17EEF2K1.79463451
18TTK1.77120855
19SMG11.76100471
20IRAK31.74920858
21PIK3CG1.73473254
22NTRK11.56460945
23CDC42BPA1.52759395
24IRAK11.50129191
25CSK1.45716271
26CAMKK21.42140063
27AKT31.40964401
28EIF2AK31.27668314
29PNCK1.17495511
30BRD41.16145294
31STK101.16103634
32LRRK21.16065015
33BMPR21.14519908
34FLT31.12724111
35ERBB31.11336338
36MAPK131.11252392
37STK38L1.10018509
38CASK1.08700050
39TRPM71.08283216
40PRKCH1.07552802
41BCR1.07512176
42PRKD21.05767761
43EPHB11.05274354
44MST1R1.02665855
45PAK31.02088756
46MAP3K71.01293746
47TESK10.97391807
48TLK10.97304809
49IRAK20.95640450
50DYRK1B0.94575997
51PRKCE0.90360173
52BMPR1B0.89639657
53PTK20.86449221
54EPHA30.84770343
55WNK10.83252380
56LATS10.80983511
57MARK20.80972522
58RIPK40.79841282
59SCYL20.78624532
60MAP3K10.78449517
61TBK10.77832215
62CAMKK10.76926252
63MARK10.71980498
64ERBB20.71810792
65STK380.70671918
66MAP3K120.67971579
67RPS6KA20.67822214
68NEK60.67476461
69BRAF0.65044122
70FER0.63387295
71PRKCI0.60872155
72CAMK2D0.60814124
73VRK10.59439043
74DYRK1A0.59364883
75BRSK20.58796544
76MAP2K20.57968854
77NME10.57726128
78ERN10.56206431
79SGK2230.53809696
80SGK4940.53809696
81SGK20.53149439
82MAP3K30.53137804
83PDGFRA0.52735883
84ICK0.51880368
85EPHA20.51856840
86AURKA0.50442519
87CAMK2B0.50204407
88TNIK0.49620171
89STK160.47259940
90NEK90.46914141
91SIK30.46877793
92PRKCQ0.46052205
93MET0.46010006
94CAMK2G0.45853744
95IRAK40.45494344
96PTK60.44928385
97DYRK30.44887387
98CDK50.44092590
99PRKACA0.43811284
100PRKCG0.43718747
101GRK70.43220014
102CSNK1A10.42804042
103RPS6KB10.41570667
104GRK50.41316081
105GSK3A0.40946129
106PRKCD0.40328300
107RIPK10.39914759
108DYRK20.39893710
109ZAK0.39666814
110TSSK60.39295221
111CDK30.38852215
112MAP2K70.38484913
113NLK0.37914950
114ADRBK10.37779802
115PRKACG0.36742017
116PRKAA20.36041398
117PRKAA10.35552604
118YES10.35285721
119RPS6KB20.33947996
120MAP2K40.33885438
121GRK60.33822538
122PRKDC0.33200648
123PBK0.32554121
124ROCK20.31905266
125TRIB30.31696485
126EPHA40.31121179
127ITK0.30504385
128MAPK100.29991313
129CAMK2A0.29645138
130MUSK0.29417496
131PRKG20.29384607
132MAPKAPK50.29216260
133GRK10.29083218
134ADRBK20.28943907
135PRKCA0.27398620
136NTRK20.26888040
137PRKG10.26408022
138MAP3K40.26261607
139TAOK10.25744427
140MINK10.24653107
141PDPK10.24505580
142IGF1R0.24457739
143CCNB10.24428217
144PAK40.22719422
145ROCK10.22676524
146SGK10.22455664
147ABL10.22296147
148RPS6KA30.20974915
149AKT20.20744369
150FYN0.20681994
151RPS6KA50.20629124
152FGFR30.20594352
153PLK10.18806091
154OXSR10.17789460
155SRC0.17655294
156CDK60.17650564
157LMTK20.16794565
158RET0.14579181
159MYLK0.13597261
160EGFR0.12847197
161PIM20.11949991
162PRKCZ0.11874425

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.55693015
2Protein export_Homo sapiens_hsa030606.03604059
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.73902019
4Chemical carcinogenesis_Homo sapiens_hsa052044.63011208
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.41828167
6Sulfur metabolism_Homo sapiens_hsa009203.64887060
7Insulin secretion_Homo sapiens_hsa049113.21716788
8beta-Alanine metabolism_Homo sapiens_hsa004103.09858056
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.83157092
10Glutathione metabolism_Homo sapiens_hsa004802.75219083
11Caffeine metabolism_Homo sapiens_hsa002322.29632264
12Retinol metabolism_Homo sapiens_hsa008302.28585035
13Vibrio cholerae infection_Homo sapiens_hsa051102.16661100
14Cocaine addiction_Homo sapiens_hsa050301.96748344
15Type I diabetes mellitus_Homo sapiens_hsa049401.90002307
16Type II diabetes mellitus_Homo sapiens_hsa049301.83824796
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.71206371
18Amphetamine addiction_Homo sapiens_hsa050311.62385857
19N-Glycan biosynthesis_Homo sapiens_hsa005101.56279425
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53936552
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52429938
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.51818933
23Circadian rhythm_Homo sapiens_hsa047101.50851212
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47598365
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.46429250
26Tight junction_Homo sapiens_hsa045301.44852996
27Taste transduction_Homo sapiens_hsa047421.34743921
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.28514758
29Regulation of autophagy_Homo sapiens_hsa041401.27002904
30Fatty acid degradation_Homo sapiens_hsa000711.22114998
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21635467
32Lysosome_Homo sapiens_hsa041421.19589696
33Selenocompound metabolism_Homo sapiens_hsa004501.17022872
34Collecting duct acid secretion_Homo sapiens_hsa049661.15761338
35Other glycan degradation_Homo sapiens_hsa005111.15111043
36Dopaminergic synapse_Homo sapiens_hsa047281.13289276
37Peroxisome_Homo sapiens_hsa041461.13017357
38Synaptic vesicle cycle_Homo sapiens_hsa047211.09686986
39Serotonergic synapse_Homo sapiens_hsa047261.04766607
40Glucagon signaling pathway_Homo sapiens_hsa049221.03349855
41GABAergic synapse_Homo sapiens_hsa047271.03116038
42Circadian entrainment_Homo sapiens_hsa047131.00322877
43Thyroid hormone synthesis_Homo sapiens_hsa049180.99421754
44Arachidonic acid metabolism_Homo sapiens_hsa005900.96620642
45Long-term potentiation_Homo sapiens_hsa047200.94285256
46Oxidative phosphorylation_Homo sapiens_hsa001900.93554995
47Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93142309
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92796358
49Sphingolipid metabolism_Homo sapiens_hsa006000.92594341
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91940267
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91849855
52Pancreatic secretion_Homo sapiens_hsa049720.90624201
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87624024
54Prion diseases_Homo sapiens_hsa050200.86718331
55Cholinergic synapse_Homo sapiens_hsa047250.82905744
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82752887
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81566675
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78830450
59Galactose metabolism_Homo sapiens_hsa000520.76441142
60Notch signaling pathway_Homo sapiens_hsa043300.76050697
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74152608
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.70744639
63Folate biosynthesis_Homo sapiens_hsa007900.70544984
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.70066064
65Alzheimers disease_Homo sapiens_hsa050100.69616450
66Morphine addiction_Homo sapiens_hsa050320.69483247
67Choline metabolism in cancer_Homo sapiens_hsa052310.68364751
68Basal cell carcinoma_Homo sapiens_hsa052170.66975311
69Estrogen signaling pathway_Homo sapiens_hsa049150.65698803
70Prolactin signaling pathway_Homo sapiens_hsa049170.65501445
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65343404
72Renin secretion_Homo sapiens_hsa049240.64784304
73Linoleic acid metabolism_Homo sapiens_hsa005910.64741891
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64599432
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64413760
76Alcoholism_Homo sapiens_hsa050340.63514730
77Adherens junction_Homo sapiens_hsa045200.63267957
78ABC transporters_Homo sapiens_hsa020100.61361940
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61250184
80Insulin resistance_Homo sapiens_hsa049310.60953806
81Hepatitis C_Homo sapiens_hsa051600.60494676
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58486652
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.55628294
84Butanoate metabolism_Homo sapiens_hsa006500.55452410
85Glutamatergic synapse_Homo sapiens_hsa047240.54443069
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53662020
87Parkinsons disease_Homo sapiens_hsa050120.52385055
88Tryptophan metabolism_Homo sapiens_hsa003800.51689985
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51406703
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50744811
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50148062
92Complement and coagulation cascades_Homo sapiens_hsa046100.50134157
93Huntingtons disease_Homo sapiens_hsa050160.50104107
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49854951
95Phenylalanine metabolism_Homo sapiens_hsa003600.48715756
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.48140113
97Hematopoietic cell lineage_Homo sapiens_hsa046400.48040132
98Starch and sucrose metabolism_Homo sapiens_hsa005000.47105694
99Dorso-ventral axis formation_Homo sapiens_hsa043200.46203340
100Insulin signaling pathway_Homo sapiens_hsa049100.44399613
101PPAR signaling pathway_Homo sapiens_hsa033200.44274824
102Phototransduction_Homo sapiens_hsa047440.44234789
103cAMP signaling pathway_Homo sapiens_hsa040240.42926518
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42905776
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41372304
106Nicotine addiction_Homo sapiens_hsa050330.40043441
107Olfactory transduction_Homo sapiens_hsa047400.39722713
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39592971
109Ether lipid metabolism_Homo sapiens_hsa005650.38069503
110Long-term depression_Homo sapiens_hsa047300.37983897
111Tyrosine metabolism_Homo sapiens_hsa003500.37488099
112Phagosome_Homo sapiens_hsa041450.36943148
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35937697
114Gastric acid secretion_Homo sapiens_hsa049710.35162621
115Hippo signaling pathway_Homo sapiens_hsa043900.32676634
116Melanogenesis_Homo sapiens_hsa049160.32666378
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31694317
118Metabolic pathways_Homo sapiens_hsa011000.31418198
119Amoebiasis_Homo sapiens_hsa051460.30401879
120Protein digestion and absorption_Homo sapiens_hsa049740.30111458
121Arginine and proline metabolism_Homo sapiens_hsa003300.29333561
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29264716
123Glycerolipid metabolism_Homo sapiens_hsa005610.27451825
124Inositol phosphate metabolism_Homo sapiens_hsa005620.26385859
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25807031
126AMPK signaling pathway_Homo sapiens_hsa041520.25786256
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25576619
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23746270
129Wnt signaling pathway_Homo sapiens_hsa043100.23126587
130Hedgehog signaling pathway_Homo sapiens_hsa043400.21280429
131Vitamin digestion and absorption_Homo sapiens_hsa049770.21089507
132Histidine metabolism_Homo sapiens_hsa003400.20622335
133Ovarian steroidogenesis_Homo sapiens_hsa049130.20607248
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.19569751
135Rheumatoid arthritis_Homo sapiens_hsa053230.19243239
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17912976
137Salivary secretion_Homo sapiens_hsa049700.17702136
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17623274
139Gap junction_Homo sapiens_hsa045400.17508529
140Bile secretion_Homo sapiens_hsa049760.17212163
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.17205291
142Axon guidance_Homo sapiens_hsa043600.16670341
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.16434980
144Prostate cancer_Homo sapiens_hsa052150.15924867
145Antigen processing and presentation_Homo sapiens_hsa046120.15757642
146Calcium signaling pathway_Homo sapiens_hsa040200.15109409
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.14846348
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11630309
149Dilated cardiomyopathy_Homo sapiens_hsa054140.08257120
150Graft-versus-host disease_Homo sapiens_hsa053320.07595543
151Fatty acid biosynthesis_Homo sapiens_hsa000610.07321592
152Endocytosis_Homo sapiens_hsa041440.07158380
153Autoimmune thyroid disease_Homo sapiens_hsa053200.06523480
154Allograft rejection_Homo sapiens_hsa053300.06056470

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