EFCAB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)8.29740852
2cell wall macromolecule metabolic process (GO:0044036)8.29740852
3fusion of sperm to egg plasma membrane (GO:0007342)7.00736039
4cilium or flagellum-dependent cell motility (GO:0001539)6.60533372
5multicellular organism reproduction (GO:0032504)6.07628517
6sperm-egg recognition (GO:0035036)5.56742561
7protein localization to kinetochore (GO:0034501)5.51347948
8acrosome assembly (GO:0001675)5.42698098
9mitotic chromosome condensation (GO:0007076)5.05344255
10plasma membrane fusion (GO:0045026)5.04071354
11behavioral response to nicotine (GO:0035095)5.01589065
12protein localization to chromosome, centromeric region (GO:0071459)5.01255712
13cell-cell recognition (GO:0009988)4.99456367
14kinetochore organization (GO:0051383)4.77069845
15attachment of spindle microtubules to kinetochore (GO:0008608)4.62588989
16reproduction (GO:0000003)4.60561563
17binding of sperm to zona pellucida (GO:0007339)4.57260349
18axonemal dynein complex assembly (GO:0070286)4.51361824
19mitotic metaphase plate congression (GO:0007080)4.47821673
20microtubule depolymerization (GO:0007019)4.46283812
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.46134446
22motile cilium assembly (GO:0044458)4.40403428
23DNA strand elongation involved in DNA replication (GO:0006271)4.32754159
24CENP-A containing nucleosome assembly (GO:0034080)4.32557057
25telomere maintenance via semi-conservative replication (GO:0032201)4.29086363
26chromatin remodeling at centromere (GO:0031055)4.28804586
27kinetochore assembly (GO:0051382)4.23809547
28centriole replication (GO:0007099)4.15843315
29mitotic sister chromatid segregation (GO:0000070)4.12513760
30mitotic recombination (GO:0006312)4.10993467
31DNA strand elongation (GO:0022616)4.10898591
32telomere maintenance via recombination (GO:0000722)4.10329980
33DNA replication initiation (GO:0006270)4.10041037
34DNA unwinding involved in DNA replication (GO:0006268)4.06440912
35sister chromatid segregation (GO:0000819)4.05615311
36histone exchange (GO:0043486)4.03878641
37metaphase plate congression (GO:0051310)3.97282194
38nuclear pore complex assembly (GO:0051292)3.96329323
39DNA replication checkpoint (GO:0000076)3.91830406
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.91272543
41establishment of chromosome localization (GO:0051303)3.90780179
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.88288397
43nuclear pore organization (GO:0006999)3.86318379
44male meiosis (GO:0007140)3.86178131
45piRNA metabolic process (GO:0034587)3.84843156
46DNA replication-independent nucleosome assembly (GO:0006336)3.84592237
47DNA replication-independent nucleosome organization (GO:0034724)3.84592237
48water-soluble vitamin biosynthetic process (GO:0042364)3.84027769
49regulation of centriole replication (GO:0046599)3.83255578
50mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.80882549
51regulation of chromosome segregation (GO:0051983)3.79864836
52centriole assembly (GO:0098534)3.78450266
53mitotic nuclear envelope disassembly (GO:0007077)3.73050724
54meiotic chromosome segregation (GO:0045132)3.71290324
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68374998
56ATP synthesis coupled proton transport (GO:0015986)3.68374998
57L-fucose catabolic process (GO:0042355)3.66672725
58fucose catabolic process (GO:0019317)3.66672725
59L-fucose metabolic process (GO:0042354)3.66672725
60chromosome condensation (GO:0030261)3.66148376
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65607194
62DNA replication-dependent nucleosome assembly (GO:0006335)3.63809307
63DNA replication-dependent nucleosome organization (GO:0034723)3.63809307
64positive regulation of chromosome segregation (GO:0051984)3.61131109
65protein localization to chromosome (GO:0034502)3.60034159
66regulation of spindle organization (GO:0090224)3.59628990
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56971508
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.56971508
69NADH dehydrogenase complex assembly (GO:0010257)3.56971508
70protein complex biogenesis (GO:0070271)3.55661941
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53933420
72response to pheromone (GO:0019236)3.52575936
73positive regulation of mitotic sister chromatid separation (GO:1901970)3.48085714
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48085714
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48085714
76membrane disassembly (GO:0030397)3.46501913
77nuclear envelope disassembly (GO:0051081)3.46501913
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.45899064
79spermatid nucleus differentiation (GO:0007289)3.44917992
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.44573683
81epithelial cilium movement (GO:0003351)3.44517097
82tryptophan catabolic process (GO:0006569)3.44321565
83indole-containing compound catabolic process (GO:0042436)3.44321565
84indolalkylamine catabolic process (GO:0046218)3.44321565
85single fertilization (GO:0007338)3.42196639
86establishment of protein localization to mitochondrial membrane (GO:0090151)3.41730553
87regulation of centrosome cycle (GO:0046605)3.39229667
88deoxyribonucleotide biosynthetic process (GO:0009263)3.38987224
89negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.37438752
90negative regulation of chromosome segregation (GO:0051985)3.36470221
91negative regulation of mitotic sister chromatid separation (GO:2000816)3.35455368
92negative regulation of mitotic sister chromatid segregation (GO:0033048)3.35455368
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35455368
94negative regulation of sister chromatid segregation (GO:0033046)3.35455368
95spindle checkpoint (GO:0031577)3.33116821
96mitochondrial respiratory chain complex assembly (GO:0033108)3.33104148
97indolalkylamine metabolic process (GO:0006586)3.32743262
98chromosome segregation (GO:0007059)3.31928492
99telomere maintenance via telomere lengthening (GO:0010833)3.30788982
100regulation of sister chromatid cohesion (GO:0007063)3.30737971
101mitotic sister chromatid cohesion (GO:0007064)3.30191035
102regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30174296
103cilium movement (GO:0003341)3.27684386
104meiotic nuclear division (GO:0007126)3.25947820
105mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.24931123
106kynurenine metabolic process (GO:0070189)3.24532685
107regulation of sister chromatid segregation (GO:0033045)3.23998604
108regulation of mitotic sister chromatid separation (GO:0010965)3.23998604
109regulation of mitotic sister chromatid segregation (GO:0033047)3.23998604
110DNA packaging (GO:0006323)3.21671547
111translesion synthesis (GO:0019985)3.20099663
112regulation of double-strand break repair via homologous recombination (GO:0010569)3.19345093
113regulation of mitotic spindle checkpoint (GO:1903504)3.18502053
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18502053
115chromatin assembly or disassembly (GO:0006333)3.16492444
116pore complex assembly (GO:0046931)3.12874768
117platelet dense granule organization (GO:0060155)3.09965918
118DNA deamination (GO:0045006)3.09445450
119spindle assembly checkpoint (GO:0071173)3.09202970
120synaptonemal complex assembly (GO:0007130)3.08757392
121DNA topological change (GO:0006265)3.06918059
122protein K6-linked ubiquitination (GO:0085020)3.05679433
123mitotic spindle checkpoint (GO:0071174)3.04106414
124regulation of mitotic spindle organization (GO:0060236)3.03840250
125protein-cofactor linkage (GO:0018065)3.02184973
126negative regulation of telomere maintenance (GO:0032205)2.97815316
127sulfation (GO:0051923)2.96228566
128respiratory chain complex IV assembly (GO:0008535)2.95998696
129protein polyglutamylation (GO:0018095)2.94956704
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92345615
131tryptophan metabolic process (GO:0006568)2.89253600
132nonmotile primary cilium assembly (GO:0035058)2.85575924
133nephron tubule morphogenesis (GO:0072078)2.85209024
134nephron epithelium morphogenesis (GO:0072088)2.85209024
135tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85195631
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85195631
137indole-containing compound metabolic process (GO:0042430)2.84015155
138electron transport chain (GO:0022900)2.82956588
139neuronal action potential (GO:0019228)2.78564771
140cilium organization (GO:0044782)2.76018899
141negative regulation of mast cell activation (GO:0033004)2.75267908
142respiratory electron transport chain (GO:0022904)2.74583229
143detection of light stimulus involved in visual perception (GO:0050908)2.74366137
144detection of light stimulus involved in sensory perception (GO:0050962)2.74366137
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74001507
146cilium morphogenesis (GO:0060271)2.73972734
147axoneme assembly (GO:0035082)2.73505422
148somite development (GO:0061053)2.72740036
149replication fork processing (GO:0031297)2.68736200
150cellular ketone body metabolic process (GO:0046950)2.68691636
151regulation of mesoderm development (GO:2000380)2.67441149
152serotonin metabolic process (GO:0042428)2.66413175
153cilium assembly (GO:0042384)2.66191827
154kidney morphogenesis (GO:0060993)2.65487185
155primary amino compound metabolic process (GO:1901160)2.64702227
156regulation of cilium movement (GO:0003352)2.64321062
157exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.63737157
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.60899989
159cytochrome complex assembly (GO:0017004)2.60683834
160recombinational repair (GO:0000725)2.59823762
161mannosylation (GO:0097502)2.58225853
162preassembly of GPI anchor in ER membrane (GO:0016254)2.58216558
163gamma-aminobutyric acid transport (GO:0015812)2.58022982
164regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57913217
165double-strand break repair via homologous recombination (GO:0000724)2.57372653
166spinal cord motor neuron differentiation (GO:0021522)2.55655888
167protein neddylation (GO:0045116)2.52803972
168rhodopsin mediated signaling pathway (GO:0016056)2.52750420
169neuron fate determination (GO:0048664)2.51545170
170regulation of action potential (GO:0098900)2.51006389
171hindbrain development (GO:0030902)2.50040373
172DNA methylation involved in gamete generation (GO:0043046)2.48593686
173cell proliferation in forebrain (GO:0021846)2.47039586
174reflex (GO:0060004)2.46526617
175ubiquinone biosynthetic process (GO:0006744)2.45055113
176intraciliary transport (GO:0042073)2.44269097
177behavioral response to ethanol (GO:0048149)2.42249933
178cellular response to ATP (GO:0071318)2.41403447
179sperm motility (GO:0030317)2.41264467
180L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40958475
181synapsis (GO:0007129)2.40840538
182regulation of nuclear cell cycle DNA replication (GO:0033262)2.40329036
183cellular biogenic amine catabolic process (GO:0042402)2.39972443
184amine catabolic process (GO:0009310)2.39972443
185reciprocal meiotic recombination (GO:0007131)2.39931226
186reciprocal DNA recombination (GO:0035825)2.39931226
187termination of RNA polymerase III transcription (GO:0006386)2.39493699
188transcription elongation from RNA polymerase III promoter (GO:0006385)2.39493699
189cornea development in camera-type eye (GO:0061303)2.38874814
190retinal cone cell development (GO:0046549)2.38777494
191ketone body metabolic process (GO:1902224)2.37500015
192negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37201890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.55871112
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.75452209
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.95458359
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.34034276
5ZNF274_21170338_ChIP-Seq_K562_Hela3.94722212
6EZH2_22144423_ChIP-Seq_EOC_Human3.86814285
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.35620672
8VDR_22108803_ChIP-Seq_LS180_Human3.19194012
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77490848
10GBX2_23144817_ChIP-Seq_PC3_Human2.77258254
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.56959302
12AR_21909140_ChIP-Seq_LNCAP_Human2.56578948
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56118223
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52068949
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48193693
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43809488
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.43227879
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41560044
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35188659
20FUS_26573619_Chip-Seq_HEK293_Human2.29055548
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26791417
22EWS_26573619_Chip-Seq_HEK293_Human2.25493921
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.22596620
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19561837
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18328025
26XRN2_22483619_ChIP-Seq_HELA_Human2.18304472
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14600145
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.13862833
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04092075
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02814537
31E2F7_22180533_ChIP-Seq_HELA_Human10.2486877
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99833777
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99807886
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.97278149
35IGF1R_20145208_ChIP-Seq_DFB_Human1.96403579
36P300_19829295_ChIP-Seq_ESCs_Human1.95764468
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94471942
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94085246
39ETS1_20019798_ChIP-Seq_JURKAT_Human1.91708325
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.91422408
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85671458
42TAF15_26573619_Chip-Seq_HEK293_Human1.85180086
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84860168
44VDR_23849224_ChIP-Seq_CD4+_Human1.83248859
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82808568
46FOXP3_21729870_ChIP-Seq_TREG_Human1.81467277
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78453758
48TTF2_22483619_ChIP-Seq_HELA_Human1.78037409
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.77847113
50ER_23166858_ChIP-Seq_MCF-7_Human1.75887881
51IRF1_19129219_ChIP-ChIP_H3396_Human1.74722184
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72417902
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64439248
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61172210
55DCP1A_22483619_ChIP-Seq_HELA_Human1.59321336
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59056387
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.56770018
58GABP_19822575_ChIP-Seq_HepG2_Human1.51058569
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50630853
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50420965
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49834881
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49130364
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.47623099
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46757589
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45387700
66TP53_22573176_ChIP-Seq_HFKS_Human1.45207409
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43447958
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.42981671
69ELK1_19687146_ChIP-ChIP_HELA_Human1.42127116
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41943766
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40733279
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40733279
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39500147
74CBP_20019798_ChIP-Seq_JUKART_Human1.39500147
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37508884
76E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36333803
77AR_25329375_ChIP-Seq_VCAP_Human1.35592442
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34589161
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.34589161
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.34132851
81STAT3_23295773_ChIP-Seq_U87_Human1.34132151
82SOX2_19829295_ChIP-Seq_ESCs_Human1.33414742
83NANOG_19829295_ChIP-Seq_ESCs_Human1.33414742
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32399170
85BCAT_22108803_ChIP-Seq_LS180_Human1.32321654
86ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31751435
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30875769
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30873955
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30569116
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29718009
91SMAD4_21799915_ChIP-Seq_A2780_Human1.29617261
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27862157
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27372565
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.27229026
95TCF4_23295773_ChIP-Seq_U87_Human1.26619426
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25314238
97REST_21632747_ChIP-Seq_MESCs_Mouse1.24814808
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24742207
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24555446
100TCF4_22108803_ChIP-Seq_LS180_Human1.24128183
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.23640630
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22749742
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22617973
104KAP1_22055183_ChIP-Seq_ESCs_Mouse1.20744655
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20476499
106AR_21572438_ChIP-Seq_LNCaP_Human1.20431509
107RNF2_27304074_Chip-Seq_NSC_Mouse1.19753912
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18892698
109KDM5A_27292631_Chip-Seq_BREAST_Human1.15639355
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.15109889
111AR_20517297_ChIP-Seq_VCAP_Human1.14934296
112NCOR_22424771_ChIP-Seq_293T_Human1.12552854
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12426250
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12101596
115ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11158562
116RUNX2_22187159_ChIP-Seq_PCA_Human1.10995234
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.10888321
118HOXB7_26014856_ChIP-Seq_BT474_Human1.08018301
119PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07629681
120SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07627880
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07205723
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07092989
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07074177
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05223936
125NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04940839
126AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04898262
127EED_16625203_ChIP-ChIP_MESCs_Mouse1.04858680
128NFE2_27457419_Chip-Seq_LIVER_Mouse1.04711898
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03990192
130MYC_22102868_ChIP-Seq_BL_Human1.03880309
131FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03836769
132EZH2_27294783_Chip-Seq_NPCs_Mouse1.02172107
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02111388
134MYC_18940864_ChIP-ChIP_HL60_Human1.01196509
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.00132414
136SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99580338
137FLI1_21867929_ChIP-Seq_TH2_Mouse0.98697762
138ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97857938
139FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97068921
140EZH2_27304074_Chip-Seq_ESCs_Mouse0.96758103
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95808187
142RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94544487
143CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94044666
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93875651
145ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93703903
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93241786
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.92926025
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92852434
149CIITA_25753668_ChIP-Seq_RAJI_Human0.91936916
150JUN_21703547_ChIP-Seq_K562_Human0.90698043
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89409439
152GATA1_26923725_Chip-Seq_HPCs_Mouse0.89047449
153ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89031233
154POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87370613
155SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.86812171
156SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84021982
157YY1_21170310_ChIP-Seq_MESCs_Mouse0.83749139
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83322004
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82413747
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81839993
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81556824
162TP63_19390658_ChIP-ChIP_HaCaT_Human0.79571157
163NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78606468
164SRF_21415370_ChIP-Seq_HL-1_Mouse0.78543643
165DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76508577
166KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76226387
167SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76157340
168NOTCH1_21737748_ChIP-Seq_TLL_Human0.75282003
169CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73099862
170SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73077606
171TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72926226
172VDR_21846776_ChIP-Seq_THP-1_Human0.69733710
173SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66073824
174IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.65678652
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.64608451
176CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.64222655
177NANOG_21062744_ChIP-ChIP_HESCs_Human0.63925154
178CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.62523568
179CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.61235888
180SPI1_23547873_ChIP-Seq_NB4_Human0.60518505
181SCL_19346495_ChIP-Seq_HPC-7_Human0.58838053
182SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.56935816
183TFEB_21752829_ChIP-Seq_HELA_Human0.55660641
184BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.55235413
185GATA3_21867929_ChIP-Seq_CD8_Mouse0.55014367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.16893744
2MP0003693_abnormal_embryo_hatching4.23549520
3MP0003111_abnormal_nucleus_morphology4.10894850
4MP0008877_abnormal_DNA_methylation4.01095533
5MP0003077_abnormal_cell_cycle3.77775190
6MP0008057_abnormal_DNA_replication3.69535574
7MP0004957_abnormal_blastocyst_morpholog3.41140529
8MP0008058_abnormal_DNA_repair3.39480669
9MP0005410_abnormal_fertilization3.25783518
10MP0002653_abnormal_ependyma_morphology3.05275018
11MP0002102_abnormal_ear_morphology2.68498786
12MP0003195_calcinosis2.59826925
13MP0008007_abnormal_cellular_replicative2.54951226
14MP0008932_abnormal_embryonic_tissue2.54606573
15MP0001929_abnormal_gametogenesis2.47418710
16MP0000569_abnormal_digit_pigmentation2.35043667
17MP0005551_abnormal_eye_electrophysiolog2.30562964
18MP0002210_abnormal_sex_determination2.28956391
19MP0006072_abnormal_retinal_apoptosis2.16992904
20MP0003890_abnormal_embryonic-extraembry2.08873857
21MP0003698_abnormal_male_reproductive2.04006940
22MP0004142_abnormal_muscle_tone1.96330843
23MP0001968_abnormal_touch/_nociception1.93331760
24MP0001145_abnormal_male_reproductive1.92473056
25MP0001730_embryonic_growth_arrest1.91379011
26MP0008872_abnormal_physiological_respon1.90041939
27MP0002837_dystrophic_cardiac_calcinosis1.89299434
28MP0010307_abnormal_tumor_latency1.84416262
29MP0000350_abnormal_cell_proliferation1.83668634
30MP0005084_abnormal_gallbladder_morpholo1.83424899
31MP0003646_muscle_fatigue1.82895693
32MP0000653_abnormal_sex_gland1.79600238
33MP0008875_abnormal_xenobiotic_pharmacok1.78508464
34MP0009046_muscle_twitch1.78147393
35MP0000631_abnormal_neuroendocrine_gland1.77268249
36MP0005646_abnormal_pituitary_gland1.76615442
37MP0002736_abnormal_nociception_after1.73387514
38MP0003011_delayed_dark_adaptation1.68203179
39MP0009745_abnormal_behavioral_response1.66161229
40MP0009379_abnormal_foot_pigmentation1.65416875
41MP0010352_gastrointestinal_tract_polyps1.63839229
42MP0004808_abnormal_hematopoietic_stem1.63740245
43MP0002638_abnormal_pupillary_reflex1.62913379
44MP0002396_abnormal_hematopoietic_system1.62496050
45MP0001986_abnormal_taste_sensitivity1.59838708
46MP0003880_abnormal_central_pattern1.59830340
47MP0002876_abnormal_thyroid_physiology1.58429988
48MP0001485_abnormal_pinna_reflex1.58162110
49MP0005253_abnormal_eye_physiology1.57762073
50MP0010030_abnormal_orbit_morphology1.57669739
51MP0005380_embryogenesis_phenotype1.56117086
52MP0001672_abnormal_embryogenesis/_devel1.56117086
53MP0001529_abnormal_vocalization1.54206851
54MP0001697_abnormal_embryo_size1.53272150
55MP0003786_premature_aging1.52771638
56MP0004043_abnormal_pH_regulation1.52615410
57MP0002272_abnormal_nervous_system1.51106783
58MP0000372_irregular_coat_pigmentation1.50972339
59MP0003123_paternal_imprinting1.49948975
60MP0004885_abnormal_endolymph1.49215558
61MP0002085_abnormal_embryonic_tissue1.45273583
62MP0003984_embryonic_growth_retardation1.42742270
63MP0001293_anophthalmia1.39966586
64MP0002084_abnormal_developmental_patter1.39248740
65MP0002019_abnormal_tumor_incidence1.38304888
66MP0000490_abnormal_crypts_of1.38221465
67MP0000313_abnormal_cell_death1.37664622
68MP0002088_abnormal_embryonic_growth/wei1.36799611
69MP0002161_abnormal_fertility/fecundity1.34913574
70MP0000383_abnormal_hair_follicle1.34026942
71MP0005076_abnormal_cell_differentiation1.30100495
72MP0008789_abnormal_olfactory_epithelium1.29769348
73MP0003718_maternal_effect1.27559858
74MP0003705_abnormal_hypodermis_morpholog1.27556429
75MP0002080_prenatal_lethality1.26826687
76MP0002282_abnormal_trachea_morphology1.24607918
77MP0002234_abnormal_pharynx_morphology1.22535014
78MP0006276_abnormal_autonomic_nervous1.22109911
79MP0001501_abnormal_sleep_pattern1.22027501
80MP0001119_abnormal_female_reproductive1.21889432
81MP0004145_abnormal_muscle_electrophysio1.21070663
82MP0004147_increased_porphyrin_level1.20990209
83MP0003283_abnormal_digestive_organ1.20202919
84MP0003119_abnormal_digestive_system1.19866424
85MP0002160_abnormal_reproductive_system1.18011706
86MP0004742_abnormal_vestibular_system1.17188755
87MP0001486_abnormal_startle_reflex1.16139908
88MP0003937_abnormal_limbs/digits/tail_de1.15282135
89MP0002557_abnormal_social/conspecific_i1.14703605
90MP0002572_abnormal_emotion/affect_behav1.13854647
91MP0002277_abnormal_respiratory_mucosa1.13082920
92MP0002735_abnormal_chemical_nociception1.12769449
93MP0005195_abnormal_posterior_eye1.11365322
94MP0000703_abnormal_thymus_morphology1.10535630
95MP0000026_abnormal_inner_ear1.10360275
96MP0005623_abnormal_meninges_morphology1.09823446
97MP0006292_abnormal_olfactory_placode1.09412163
98MP0003787_abnormal_imprinting1.09319515
99MP0002064_seizures1.08012900
100MP0004197_abnormal_fetal_growth/weight/1.07849306
101MP0005645_abnormal_hypothalamus_physiol1.06826258
102MP0009053_abnormal_anal_canal1.05286321
103MP0002086_abnormal_extraembryonic_tissu1.01529731
104MP0004133_heterotaxia1.00172160
105MP0005171_absent_coat_pigmentation0.99938577
106MP0003121_genomic_imprinting0.99637790
107MP0002138_abnormal_hepatobiliary_system0.99159076
108MP0002067_abnormal_sensory_capabilities0.98781401
109MP0008995_early_reproductive_senescence0.98326118
110MP0005377_hearing/vestibular/ear_phenot0.98059138
111MP0003878_abnormal_ear_physiology0.98059138
112MP0004233_abnormal_muscle_weight0.97539717
113MP0001970_abnormal_pain_threshold0.96502725
114MP0001905_abnormal_dopamine_level0.95927564
115MP0001919_abnormal_reproductive_system0.95117140
116MP0000049_abnormal_middle_ear0.94988084
117MP0005394_taste/olfaction_phenotype0.94203620
118MP0005499_abnormal_olfactory_system0.94203620
119MP0002752_abnormal_somatic_nervous0.93767953
120MP0002163_abnormal_gland_morphology0.93585014
121MP0003763_abnormal_thymus_physiology0.93056647
122MP0002398_abnormal_bone_marrow0.92134182
123MP0002734_abnormal_mechanical_nocicepti0.91962301
124MP0005389_reproductive_system_phenotype0.91080174
125MP0005379_endocrine/exocrine_gland_phen0.91026783
126MP0000778_abnormal_nervous_system0.90835361
127MP0001324_abnormal_eye_pigmentation0.90416091
128MP0002733_abnormal_thermal_nociception0.90093882
129MP0000566_synostosis0.90091758
130MP0003567_abnormal_fetal_cardiomyocyte0.87937863
131MP0002751_abnormal_autonomic_nervous0.87904752
132MP0005174_abnormal_tail_pigmentation0.86883929
133MP0005085_abnormal_gallbladder_physiolo0.86581750
134MP0000647_abnormal_sebaceous_gland0.85417192
135MP0003315_abnormal_perineum_morphology0.85069506
136MP0000432_abnormal_head_morphology0.84910389
137MP0005386_behavior/neurological_phenoty0.84433803
138MP0004924_abnormal_behavior0.84433803
139MP0003635_abnormal_synaptic_transmissio0.82840406
140MP0002063_abnormal_learning/memory/cond0.82508836
141MP0001545_abnormal_hematopoietic_system0.80712313
142MP0005397_hematopoietic_system_phenotyp0.80712313
143MP0002722_abnormal_immune_system0.79711511
144MP0000689_abnormal_spleen_morphology0.77697831
145MP0006054_spinal_hemorrhage0.77495099
146MP0002184_abnormal_innervation0.77191533
147MP0003699_abnormal_female_reproductive0.74959497
148MP0002095_abnormal_skin_pigmentation0.72569083
149MP0003935_abnormal_craniofacial_develop0.72561710
150MP0001915_intracranial_hemorrhage0.71180856
151MP0003861_abnormal_nervous_system0.69571134
152MP0002092_abnormal_eye_morphology0.68951370
153MP0002429_abnormal_blood_cell0.68911903
154MP0002938_white_spotting0.68835101
155MP0000428_abnormal_craniofacial_morphol0.68142225
156MP0001984_abnormal_olfaction0.67480559
157MP0003136_yellow_coat_color0.67325953
158MP0003221_abnormal_cardiomyocyte_apopto0.66612170
159MP0000858_altered_metastatic_potential0.66041177
160MP0009697_abnormal_copulation0.65852953
161MP0002928_abnormal_bile_duct0.65810036
162MP0002132_abnormal_respiratory_system0.64818619
163MP0003115_abnormal_respiratory_system0.63758960
164MP0002932_abnormal_joint_morphology0.62206854
165MP0002233_abnormal_nose_morphology0.61651971
166MP0003755_abnormal_palate_morphology0.60345127
167MP0001286_abnormal_eye_development0.59920283
168MP0000427_abnormal_hair_cycle0.59650914
169MP0000716_abnormal_immune_system0.59561478
170MP0002249_abnormal_larynx_morphology0.57062439
171MP0009333_abnormal_splenocyte_physiolog0.56370487
172MP0009672_abnormal_birth_weight0.56164111

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.12844479
2Abnormal respiratory motile cilium physiology (HP:0012261)5.75679019
3Rhinitis (HP:0012384)5.29614806
4Abnormal ciliary motility (HP:0012262)5.15786226
5Absent/shortened dynein arms (HP:0200106)5.14016088
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.14016088
7Abnormal respiratory motile cilium morphology (HP:0005938)5.13101893
8Abnormal respiratory epithelium morphology (HP:0012253)5.13101893
9Chronic bronchitis (HP:0004469)3.97219391
10Nasal polyposis (HP:0100582)3.83342449
11Congenital stationary night blindness (HP:0007642)3.56132919
12Birth length less than 3rd percentile (HP:0003561)3.50336313
13Tongue fasciculations (HP:0001308)3.50077335
14Chromsome breakage (HP:0040012)3.35519051
15Bronchiectasis (HP:0002110)3.35263464
16Increased nuchal translucency (HP:0010880)3.33488060
17Congenital primary aphakia (HP:0007707)3.30154460
18Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22487437
19Chronic otitis media (HP:0000389)3.18587040
20Muscle fibrillation (HP:0010546)3.15999291
21Abnormality of the renal medulla (HP:0100957)3.13330304
22Supernumerary spleens (HP:0009799)3.12215985
23Medial flaring of the eyebrow (HP:0010747)3.10827885
24Gait imbalance (HP:0002141)3.06927771
25Type II lissencephaly (HP:0007260)2.99472624
26Abnormality of the renal cortex (HP:0011035)2.95637473
27Bronchitis (HP:0012387)2.95492474
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92599918
29Abnormality of alanine metabolism (HP:0010916)2.92599918
30Hyperalaninemia (HP:0003348)2.92599918
31Abnormality of the nasal mucosa (HP:0000433)2.90255735
32Impulsivity (HP:0100710)2.89636737
33Pendular nystagmus (HP:0012043)2.88620669
34Chronic sinusitis (HP:0011109)2.87166670
35Facial hemangioma (HP:0000329)2.84168926
36Abnormal lung lobation (HP:0002101)2.83231516
37Acute necrotizing encephalopathy (HP:0006965)2.77153175
38Chronic hepatic failure (HP:0100626)2.76955227
39Cystic liver disease (HP:0006706)2.75710481
40Tubular atrophy (HP:0000092)2.75104808
41Nephrogenic diabetes insipidus (HP:0009806)2.72446802
42Patellar aplasia (HP:0006443)2.71722673
43Reticulocytopenia (HP:0001896)2.69412498
44Abnormality of chromosome stability (HP:0003220)2.68004549
45Colon cancer (HP:0003003)2.67484053
46Sloping forehead (HP:0000340)2.62924177
47Congenital, generalized hypertrichosis (HP:0004540)2.61808872
48Sclerocornea (HP:0000647)2.59165674
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.57317654
50Recurrent sinusitis (HP:0011108)2.55158081
51Abolished electroretinogram (ERG) (HP:0000550)2.49997831
52Aplasia/Hypoplasia of the patella (HP:0006498)2.48963149
53Small intestinal stenosis (HP:0012848)2.47931624
54Duodenal stenosis (HP:0100867)2.47931624
55Poor coordination (HP:0002370)2.47190854
56Attenuation of retinal blood vessels (HP:0007843)2.44775221
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.44447374
58Mitochondrial inheritance (HP:0001427)2.43558693
59Meckel diverticulum (HP:0002245)2.41747329
60Short 4th metacarpal (HP:0010044)2.41053258
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.41053258
62Acute encephalopathy (HP:0006846)2.40306102
63Abnormal number of erythroid precursors (HP:0012131)2.40002376
64Nephroblastoma (Wilms tumor) (HP:0002667)2.37513923
65Selective tooth agenesis (HP:0001592)2.37368657
66Abnormal spermatogenesis (HP:0008669)2.33795945
67Progressive macrocephaly (HP:0004481)2.33111032
68Bile duct proliferation (HP:0001408)2.32799246
69Abnormal biliary tract physiology (HP:0012439)2.32799246
70Abnormal mitochondria in muscle tissue (HP:0008316)2.32275393
71Toxemia of pregnancy (HP:0100603)2.31639509
72Abnormality of the ileum (HP:0001549)2.31423737
73Increased CSF lactate (HP:0002490)2.30488406
74Large for gestational age (HP:0001520)2.30445743
75Abnormality of the pons (HP:0007361)2.30011988
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.29655321
77Cerebellar dysplasia (HP:0007033)2.27956018
78Nephronophthisis (HP:0000090)2.27947532
7911 pairs of ribs (HP:0000878)2.27816592
80Recurrent bronchitis (HP:0002837)2.27674529
81Breast hypoplasia (HP:0003187)2.25940502
82Abnormal rod and cone electroretinograms (HP:0008323)2.24565312
83Concave nail (HP:0001598)2.24134848
84Hyperventilation (HP:0002883)2.23974177
85Hypoplasia of the pons (HP:0012110)2.23860804
86Ectopic kidney (HP:0000086)2.23397189
87Medulloblastoma (HP:0002885)2.22609337
88Pancreatic fibrosis (HP:0100732)2.19666765
89Embryonal renal neoplasm (HP:0011794)2.19513856
90Renal cortical cysts (HP:0000803)2.19356391
91Methylmalonic acidemia (HP:0002912)2.19250053
92Optic nerve hypoplasia (HP:0000609)2.17943306
93Renal duplication (HP:0000075)2.17320406
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17255651
95Abnormality of the preputium (HP:0100587)2.16689624
96Furrowed tongue (HP:0000221)2.15820795
97Abnormality of the carotid arteries (HP:0005344)2.15791202
98Increased corneal curvature (HP:0100692)2.14944091
99Keratoconus (HP:0000563)2.14944091
100Cleft eyelid (HP:0000625)2.12372237
101Genital tract atresia (HP:0001827)2.12151877
102Abnormality of cells of the erythroid lineage (HP:0012130)2.12062932
103Aplasia/Hypoplasia of the sternum (HP:0006714)2.11750385
104Male pseudohermaphroditism (HP:0000037)2.11527190
105Congenital hepatic fibrosis (HP:0002612)2.11212324
106Recurrent otitis media (HP:0000403)2.10562244
107Myelodysplasia (HP:0002863)2.07471733
108Abnormal drinking behavior (HP:0030082)2.07150260
109Polydipsia (HP:0001959)2.07150260
110Vaginal atresia (HP:0000148)2.07122932
111Pancreatic cysts (HP:0001737)2.07008074
112Renovascular hypertension (HP:0100817)2.04404006
113Inability to walk (HP:0002540)2.03827167
114Papillary thyroid carcinoma (HP:0002895)2.03503192
115Hyperacusis (HP:0010780)2.03481667
116Chorioretinal atrophy (HP:0000533)2.01718086
1173-Methylglutaconic aciduria (HP:0003535)2.01346487
118Short tibia (HP:0005736)2.00684801
119Absent radius (HP:0003974)1.99531816
120Hyperglycinemia (HP:0002154)1.98637536
121Septo-optic dysplasia (HP:0100842)1.98045572
122Microglossia (HP:0000171)1.97675978
123Molar tooth sign on MRI (HP:0002419)1.96903737
124Abnormality of midbrain morphology (HP:0002418)1.96903737
125Optic disc pallor (HP:0000543)1.96795909
126Aplasia/Hypoplasia of the tongue (HP:0010295)1.95036040
127Volvulus (HP:0002580)1.94274990
128Broad foot (HP:0001769)1.93567358
129Decreased central vision (HP:0007663)1.93536572
130Lipid accumulation in hepatocytes (HP:0006561)1.93153569
131Lissencephaly (HP:0001339)1.91080859
132Methylmalonic aciduria (HP:0012120)1.90285936
133Abnormality of the duodenum (HP:0002246)1.90095782
134Hepatocellular necrosis (HP:0001404)1.89836446
135Rhabdomyosarcoma (HP:0002859)1.89182998
136Occipital encephalocele (HP:0002085)1.88395272
137Abnormality of the labia minora (HP:0012880)1.87219117
138Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86579036
139Hepatic necrosis (HP:0002605)1.86352803
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86169957
141Absent epiphyses (HP:0010577)1.86169957
142Facial cleft (HP:0002006)1.85469288
143Azoospermia (HP:0000027)1.85407808
144Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85170726
145Gaze-evoked nystagmus (HP:0000640)1.84713662
146Deep philtrum (HP:0002002)1.84591970
147Absent forearm bone (HP:0003953)1.83992201
148Aplasia involving forearm bones (HP:0009822)1.83992201
149Increased hepatocellular lipid droplets (HP:0006565)1.83674485
150Bony spicule pigmentary retinopathy (HP:0007737)1.83290215
151True hermaphroditism (HP:0010459)1.82575102
152Overriding aorta (HP:0002623)1.81142986
153Progressive cerebellar ataxia (HP:0002073)1.79716097
154Absent thumb (HP:0009777)1.78514631
155Abnormality of the anterior horn cell (HP:0006802)1.78468706
156Degeneration of anterior horn cells (HP:0002398)1.78468706
157Bilateral microphthalmos (HP:0007633)1.77465176
158Preaxial hand polydactyly (HP:0001177)1.76850472
159Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76371632
160Abnormality of the diencephalon (HP:0010662)1.74946315
161High pitched voice (HP:0001620)1.74765577
162Atresia of the external auditory canal (HP:0000413)1.74575597
163Triphalangeal thumb (HP:0001199)1.74466469
164Postaxial foot polydactyly (HP:0001830)1.73714433
165Retinal dysplasia (HP:0007973)1.71795224
166Anencephaly (HP:0002323)1.68666992
167Tracheoesophageal fistula (HP:0002575)1.68609747
168Dental crowding (HP:0000678)1.68389512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.85813384
2FRK4.57005794
3WEE14.40642902
4BUB13.93239261
5PLK43.69177722
6BRSK23.45501192
7ADRBK23.20310385
8NEK23.08526422
9TTK3.00991259
10BMPR1B2.94875008
11PNCK2.50934517
12GRK12.44206333
13WNK32.41162919
14PLK12.32269720
15INSRR2.29202724
16WNK42.27783098
17BRSK12.25644868
18CHEK22.16561081
19AURKB2.10619827
20ACVR1B2.08871259
21CDK122.08719741
22MAP4K22.05603467
23PINK11.99035748
24NEK11.96778793
25PDK41.95662959
26PDK31.95662959
27VRK21.94637253
28CCNB11.93920821
29EIF2AK11.83541482
30ATR1.79817169
31TAOK31.71365129
32TESK21.71129442
33MAPK151.70439159
34CASK1.68408854
35PLK31.63315412
36STK101.62294513
37CDK71.60934979
38CDK41.57518566
39SRPK11.56338024
40VRK11.54667248
41AURKA1.48781563
42MAP3K101.47379009
43MAPK131.41190439
44MAP3K41.40276638
45TNIK1.37030776
46MKNK11.36261445
47RPS6KA41.32974737
48CDK61.31857467
49CHEK11.31268525
50MELK1.29786880
51STK38L1.24569574
52OXSR11.24188330
53STK41.22823797
54STK391.22805915
55TLK11.18939181
56CAMKK21.17908554
57NME11.17777759
58PASK1.17592404
59DYRK31.14406993
60TAF11.10245978
61MAP4K11.08842322
62ADRBK11.07584568
63NEK91.06536269
64STK161.05363307
65MAP3K81.04024906
66PBK1.00077436
67LATS10.99904700
68PRKCG0.98863081
69STK30.97756863
70ATM0.96843473
71EEF2K0.96472182
72BRAF0.96403632
73MARK10.92323455
74TESK10.91962154
75CLK10.91183112
76EIF2AK30.89668571
77MKNK20.89204321
78YES10.86409509
79PIK3CA0.83292958
80DAPK20.82263464
81MAP2K70.81687191
82PRKCE0.81629094
83TEC0.80573430
84BCKDK0.79871619
85TXK0.79576859
86MAPKAPK50.79222213
87CDK20.78490420
88PAK30.75759538
89TRIM280.74461200
90MST40.71888939
91NTRK30.71116493
92CDK10.70491427
93CAMK1G0.70331460
94FGFR20.68050570
95PDK20.68015922
96RPS6KB20.67738932
97CSNK1G20.67372237
98BRD40.66981363
99CSNK1G10.65757536
100CDK80.65736235
101CAMK1D0.65462250
102TIE10.64719367
103PAK10.63281043
104MAP3K60.62570239
105MUSK0.62011361
106ZAK0.61812016
107PAK40.61749489
108SCYL20.60655440
109EIF2AK20.59359836
110ERBB30.59212581
111CSNK1G30.59181485
112MARK30.57909319
113CSNK2A10.56893577
114BTK0.56649628
115NTRK20.56325119
116MAPKAPK30.55761430
117TSSK60.55141570
118CAMK2A0.53791482
119CAMK10.53276048
120ITK0.53224936
121PIM10.52174069
122PKN10.51735430
123PHKG10.51522200
124PHKG20.51522200
125LRRK20.50924971
126ERBB20.46964985
127CSNK2A20.46644593
128PRKACA0.46011351
129NME20.45242855
130CSNK1A1L0.44891746
131PTK2B0.44417771
132MAP2K20.44374855
133PRKCQ0.44293986
134MAPKAPK20.43470449
135GRK70.43232472
136TGFBR10.43152288
137FLT30.42508209
138EPHA40.41931816
139IKBKB0.41523641
140CSNK1A10.41402565
141EPHB20.41118333
142MOS0.38208964
143KIT0.37896581
144CDK90.37094448
145DYRK20.36678409
146MAP3K90.36651040
147PIM20.35483257
148OBSCN0.34162531
149CHUK0.33515701
150PRKCI0.33446257
151PRKDC0.32426399
152NUAK10.32344374
153STK240.31425557
154CDK180.30671931
155LATS20.30404300
156AKT20.30095341
157CDK150.30055185
158CDK11A0.29463868
159UHMK10.27702994
160DYRK1B0.26370109
161NLK0.25818383
162RPS6KA50.25334862
163PLK20.23928090
164MAPK110.20946976
165IRAK10.19428205
166MAPK140.17837506
167BMPR20.17570960

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.55996686
2Mismatch repair_Homo sapiens_hsa034304.45361336
3Homologous recombination_Homo sapiens_hsa034404.05141183
4Base excision repair_Homo sapiens_hsa034103.59183426
5Cell cycle_Homo sapiens_hsa041103.47693613
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.17247267
7Spliceosome_Homo sapiens_hsa030403.14855214
8Oxidative phosphorylation_Homo sapiens_hsa001903.11192686
9Fanconi anemia pathway_Homo sapiens_hsa034603.06564437
10RNA transport_Homo sapiens_hsa030132.95000929
11Nucleotide excision repair_Homo sapiens_hsa034202.88221134
12Basal transcription factors_Homo sapiens_hsa030222.59286427
13Phototransduction_Homo sapiens_hsa047442.57186725
14Ribosome_Homo sapiens_hsa030102.52742278
15Parkinsons disease_Homo sapiens_hsa050122.50519356
16Linoleic acid metabolism_Homo sapiens_hsa005912.43002133
17Nitrogen metabolism_Homo sapiens_hsa009102.30953534
18Pyrimidine metabolism_Homo sapiens_hsa002402.28171282
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26524424
20Proteasome_Homo sapiens_hsa030502.19974906
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15859374
22Non-homologous end-joining_Homo sapiens_hsa034502.08339443
23Maturity onset diabetes of the young_Homo sapiens_hsa049502.01502865
24Nicotine addiction_Homo sapiens_hsa050332.00147920
25Butanoate metabolism_Homo sapiens_hsa006501.93399305
26mRNA surveillance pathway_Homo sapiens_hsa030151.90942640
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84866151
28RNA degradation_Homo sapiens_hsa030181.82786393
29p53 signaling pathway_Homo sapiens_hsa041151.81905893
30One carbon pool by folate_Homo sapiens_hsa006701.80045473
31Systemic lupus erythematosus_Homo sapiens_hsa053221.75218738
32RNA polymerase_Homo sapiens_hsa030201.73464083
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73275848
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68645621
35Alzheimers disease_Homo sapiens_hsa050101.66498568
36Oocyte meiosis_Homo sapiens_hsa041141.66486984
37Caffeine metabolism_Homo sapiens_hsa002321.66319960
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61417077
39Tryptophan metabolism_Homo sapiens_hsa003801.59677855
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.58845673
41Ether lipid metabolism_Homo sapiens_hsa005651.57554732
42Pentose phosphate pathway_Homo sapiens_hsa000301.56646785
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52873298
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52330054
45Cardiac muscle contraction_Homo sapiens_hsa042601.49216142
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40988334
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36959293
48Purine metabolism_Homo sapiens_hsa002301.36310607
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25597960
50Chemical carcinogenesis_Homo sapiens_hsa052041.21025423
51Olfactory transduction_Homo sapiens_hsa047401.19398156
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18958691
53Viral carcinogenesis_Homo sapiens_hsa052031.18202614
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15666295
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.13598311
56Epstein-Barr virus infection_Homo sapiens_hsa051691.11182350
57N-Glycan biosynthesis_Homo sapiens_hsa005101.11139899
58Taste transduction_Homo sapiens_hsa047421.09555184
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05915853
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01277195
61HTLV-I infection_Homo sapiens_hsa051661.00465012
62Arachidonic acid metabolism_Homo sapiens_hsa005900.98918702
63Herpes simplex infection_Homo sapiens_hsa051680.98896258
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.94877125
65Peroxisome_Homo sapiens_hsa041460.93696671
66Morphine addiction_Homo sapiens_hsa050320.92772617
67Vitamin B6 metabolism_Homo sapiens_hsa007500.92101783
68Selenocompound metabolism_Homo sapiens_hsa004500.92078931
69Retinol metabolism_Homo sapiens_hsa008300.90829452
70Huntingtons disease_Homo sapiens_hsa050160.88367389
71beta-Alanine metabolism_Homo sapiens_hsa004100.87388537
72Sulfur relay system_Homo sapiens_hsa041220.85663903
73MicroRNAs in cancer_Homo sapiens_hsa052060.77124654
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77012989
75ABC transporters_Homo sapiens_hsa020100.75543105
76Fat digestion and absorption_Homo sapiens_hsa049750.74321726
77Serotonergic synapse_Homo sapiens_hsa047260.73704618
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.73647809
79Ovarian steroidogenesis_Homo sapiens_hsa049130.73286076
80Vitamin digestion and absorption_Homo sapiens_hsa049770.72834928
81Antigen processing and presentation_Homo sapiens_hsa046120.72118529
82Sulfur metabolism_Homo sapiens_hsa009200.71752566
83Steroid biosynthesis_Homo sapiens_hsa001000.71676183
84Biosynthesis of amino acids_Homo sapiens_hsa012300.70783820
85Histidine metabolism_Homo sapiens_hsa003400.70244825
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68750273
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66879929
88Primary immunodeficiency_Homo sapiens_hsa053400.65511356
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65322547
90Small cell lung cancer_Homo sapiens_hsa052220.64336041
91Alcoholism_Homo sapiens_hsa050340.64133822
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63876679
93Insulin secretion_Homo sapiens_hsa049110.63119807
94GABAergic synapse_Homo sapiens_hsa047270.62470526
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60745343
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60155251
97Protein export_Homo sapiens_hsa030600.59767399
98Chronic myeloid leukemia_Homo sapiens_hsa052200.59165292
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57856304
100Circadian entrainment_Homo sapiens_hsa047130.57226593
101Glutamatergic synapse_Homo sapiens_hsa047240.57060799
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.55004465
103Renin-angiotensin system_Homo sapiens_hsa046140.54464714
104Glycerolipid metabolism_Homo sapiens_hsa005610.54399176
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.53425691
106Regulation of autophagy_Homo sapiens_hsa041400.53005823
107Mineral absorption_Homo sapiens_hsa049780.52933280
108Basal cell carcinoma_Homo sapiens_hsa052170.51698966
109Colorectal cancer_Homo sapiens_hsa052100.51184599
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50107120
111Glutathione metabolism_Homo sapiens_hsa004800.49888336
112Calcium signaling pathway_Homo sapiens_hsa040200.49740729
113Carbon metabolism_Homo sapiens_hsa012000.49558501
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49543569
115Pancreatic cancer_Homo sapiens_hsa052120.49374272
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48292232
117Hepatitis B_Homo sapiens_hsa051610.47528169
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47405399
119Folate biosynthesis_Homo sapiens_hsa007900.46115308
120Hippo signaling pathway_Homo sapiens_hsa043900.44813433
121Salivary secretion_Homo sapiens_hsa049700.44048051
122Legionellosis_Homo sapiens_hsa051340.43598004
123Collecting duct acid secretion_Homo sapiens_hsa049660.43197527
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42229677
125Apoptosis_Homo sapiens_hsa042100.41085873
126Hedgehog signaling pathway_Homo sapiens_hsa043400.40448562
127TGF-beta signaling pathway_Homo sapiens_hsa043500.40218150
128Cocaine addiction_Homo sapiens_hsa050300.37624429
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37307380
130Pyruvate metabolism_Homo sapiens_hsa006200.37056817
131Viral myocarditis_Homo sapiens_hsa054160.36066142
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35820787
133Lysine degradation_Homo sapiens_hsa003100.35640122
134Shigellosis_Homo sapiens_hsa051310.35286953
135Fatty acid elongation_Homo sapiens_hsa000620.34963821
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31523296
137Adherens junction_Homo sapiens_hsa045200.29474483
138Measles_Homo sapiens_hsa051620.29053584
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.27885152
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27623686
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26643426
142Influenza A_Homo sapiens_hsa051640.25713201
143Pathways in cancer_Homo sapiens_hsa052000.24707721
144Notch signaling pathway_Homo sapiens_hsa043300.24562541
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24386458
146Bladder cancer_Homo sapiens_hsa052190.21183797
147B cell receptor signaling pathway_Homo sapiens_hsa046620.20376587
148Thyroid cancer_Homo sapiens_hsa052160.20024563
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15958558
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15302077
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15218251
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.15005065
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.14504442
154Asthma_Homo sapiens_hsa053100.13076260
155Metabolic pathways_Homo sapiens_hsa011000.13050101
156FoxO signaling pathway_Homo sapiens_hsa040680.12941638
157Wnt signaling pathway_Homo sapiens_hsa043100.12144954
158Non-small cell lung cancer_Homo sapiens_hsa052230.11487362
159Prostate cancer_Homo sapiens_hsa052150.10979733
160Hematopoietic cell lineage_Homo sapiens_hsa046400.07402622
161Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.07220417
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04394041
163Propanoate metabolism_Homo sapiens_hsa006400.02655271
164HIF-1 signaling pathway_Homo sapiens_hsa040660.02341678
165Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.00474998
166Glucagon signaling pathway_Homo sapiens_hsa04922-0.0089250

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