EFCAB12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.86530793
2epithelial cilium movement (GO:0003351)8.75845746
3motile cilium assembly (GO:0044458)8.17652805
4cell wall macromolecule metabolic process (GO:0044036)7.41490949
5cell wall macromolecule catabolic process (GO:0016998)7.41490949
6fusion of sperm to egg plasma membrane (GO:0007342)7.23326248
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.20992981
8multicellular organism reproduction (GO:0032504)6.81172967
9axoneme assembly (GO:0035082)6.79904174
10regulation of cilium movement (GO:0003352)6.22190345
11ventricular system development (GO:0021591)6.09972390
12intraciliary transport (GO:0042073)6.05390465
13plasma membrane fusion (GO:0045026)5.69016637
14sperm-egg recognition (GO:0035036)5.67266948
15acrosome assembly (GO:0001675)5.64834750
16acrosome reaction (GO:0007340)5.60174111
17sperm motility (GO:0030317)5.58751996
18protein localization to cilium (GO:0061512)5.44113885
19cilium organization (GO:0044782)5.19296368
20reproduction (GO:0000003)5.15625835
21cilium assembly (GO:0042384)5.09931901
22piRNA metabolic process (GO:0034587)5.04377063
23cell-cell recognition (GO:0009988)4.92240131
24binding of sperm to zona pellucida (GO:0007339)4.85219142
25single fertilization (GO:0007338)4.75713597
26cilium morphogenesis (GO:0060271)4.67781447
27spermatid development (GO:0007286)4.66699196
28detection of calcium ion (GO:0005513)4.63918936
29male meiosis (GO:0007140)4.57318822
30microtubule depolymerization (GO:0007019)4.53267066
31centriole assembly (GO:0098534)4.50907847
32nucleoside diphosphate phosphorylation (GO:0006165)4.40484862
33indolalkylamine metabolic process (GO:0006586)4.38629967
34tryptophan catabolic process (GO:0006569)4.37711098
35indole-containing compound catabolic process (GO:0042436)4.37711098
36indolalkylamine catabolic process (GO:0046218)4.37711098
37protein polyglutamylation (GO:0018095)4.27031263
38nonmotile primary cilium assembly (GO:0035058)4.26534648
39GTP biosynthetic process (GO:0006183)4.25100247
40response to pheromone (GO:0019236)4.24966987
41left/right axis specification (GO:0070986)4.21111991
42phosphorelay signal transduction system (GO:0000160)4.17357356
43cellular component assembly involved in morphogenesis (GO:0010927)4.11661987
44tryptophan metabolic process (GO:0006568)3.97706247
45kynurenine metabolic process (GO:0070189)3.94532755
46behavioral response to nicotine (GO:0035095)3.92971805
47L-fucose catabolic process (GO:0042355)3.89867145
48fucose catabolic process (GO:0019317)3.89867145
49L-fucose metabolic process (GO:0042354)3.89867145
50microtubule bundle formation (GO:0001578)3.88328443
51fertilization (GO:0009566)3.82835826
52cellular ketone body metabolic process (GO:0046950)3.80959707
53detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.77625400
54calcium ion-dependent exocytosis (GO:0017156)3.71874709
55male meiosis I (GO:0007141)3.56959496
56DNA methylation involved in gamete generation (GO:0043046)3.55834729
57regulation of microtubule-based movement (GO:0060632)3.53055536
58UTP biosynthetic process (GO:0006228)3.48695418
59detection of light stimulus involved in sensory perception (GO:0050962)3.46583379
60detection of light stimulus involved in visual perception (GO:0050908)3.46583379
61centriole replication (GO:0007099)3.42083747
62neural tube formation (GO:0001841)3.40456888
63ketone body metabolic process (GO:1902224)3.39165825
64spermatogenesis (GO:0007283)3.39040440
65male gamete generation (GO:0048232)3.38012107
66spermatid nucleus differentiation (GO:0007289)3.37885772
67indole-containing compound metabolic process (GO:0042430)3.32915166
68microtubule-based movement (GO:0007018)3.32415513
69gamete generation (GO:0007276)3.25717797
70synaptonemal complex organization (GO:0070193)3.24580895
71retinal cone cell development (GO:0046549)3.14187725
72left/right pattern formation (GO:0060972)3.10031456
73cell projection assembly (GO:0030031)3.08574675
74modulation by virus of host process (GO:0019054)3.05768751
75guanosine-containing compound biosynthetic process (GO:1901070)3.05128622
76benzene-containing compound metabolic process (GO:0042537)3.03804111
77negative regulation of execution phase of apoptosis (GO:1900118)3.03056248
78cellular biogenic amine catabolic process (GO:0042402)3.02008779
79amine catabolic process (GO:0009310)3.02008779
80cell recognition (GO:0008037)3.01797191
81sensory perception of smell (GO:0007608)3.01043324
82microtubule severing (GO:0051013)2.98884932
83startle response (GO:0001964)2.98696985
84negative regulation of inclusion body assembly (GO:0090084)2.98432068
85deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.97349673
86smoothened signaling pathway (GO:0007224)2.97060676
87positive regulation of meiosis (GO:0045836)2.95388065
88primary amino compound metabolic process (GO:1901160)2.95365356
89regulation of hippo signaling (GO:0035330)2.94878173
90serotonin metabolic process (GO:0042428)2.93991727
91CTP biosynthetic process (GO:0006241)2.93607191
92CTP metabolic process (GO:0046036)2.93607191
93spinal cord motor neuron differentiation (GO:0021522)2.91189886
94meiotic cell cycle (GO:0051321)2.89181759
95UTP metabolic process (GO:0046051)2.88595067
96pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.87244334
97G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85838820
98reflex (GO:0060004)2.84693454
99regulation of meiosis I (GO:0060631)2.83012938
100germ cell development (GO:0007281)2.82850212
101synaptonemal complex assembly (GO:0007130)2.81773990
102positive regulation of meiotic cell cycle (GO:0051446)2.77357921
103sperm capacitation (GO:0048240)2.76781784
104regulation of timing of cell differentiation (GO:0048505)2.76490086
105drug catabolic process (GO:0042737)2.75641739
106one-carbon compound transport (GO:0019755)2.75369788
107exogenous drug catabolic process (GO:0042738)2.73226613
108cellular process involved in reproduction in multicellular organism (GO:0022412)2.71171347
109cornea development in camera-type eye (GO:0061303)2.70689165
110establishment of protein localization to Golgi (GO:0072600)2.70407339
111NAD biosynthetic process (GO:0009435)2.70292456
112nephron tubule morphogenesis (GO:0072078)2.69738336
113nephron epithelium morphogenesis (GO:0072088)2.69738336
114rRNA catabolic process (GO:0016075)2.66655641
115neuron cell-cell adhesion (GO:0007158)2.65943441
116negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65689097
117negative regulation of T cell differentiation in thymus (GO:0033085)2.65326440
118auditory receptor cell stereocilium organization (GO:0060088)2.63891483
119thyroid hormone metabolic process (GO:0042403)2.63661772
120meiotic nuclear division (GO:0007126)2.63121075
121neuronal action potential (GO:0019228)2.61336070
122nucleoside diphosphate metabolic process (GO:0009132)2.60879515
123meiosis I (GO:0007127)2.58415024
124behavioral response to ethanol (GO:0048149)2.57780342
125photoreceptor cell maintenance (GO:0045494)2.56885296
126signal peptide processing (GO:0006465)2.56668387
127cellular response to gamma radiation (GO:0071480)2.55765228
128microtubule polymerization or depolymerization (GO:0031109)2.55192808
129organelle assembly (GO:0070925)2.53762653
130regulation of development, heterochronic (GO:0040034)2.53697444
131sulfation (GO:0051923)2.53379302
132multicellular organismal reproductive process (GO:0048609)2.53249470
133regulation of collateral sprouting (GO:0048670)2.52245819
134photoreceptor cell development (GO:0042461)2.52031252
135nucleotide phosphorylation (GO:0046939)2.51440122
136regulation of acrosome reaction (GO:0060046)2.47509775
137pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.46343186
138aromatic amino acid family catabolic process (GO:0009074)2.46320929
139organic cation transport (GO:0015695)2.45316159
140negative regulation of mast cell activation (GO:0033004)2.42567959
141regulation of action potential (GO:0098900)2.41374707
142appendage development (GO:0048736)2.41114243
143limb development (GO:0060173)2.41114243
144vocalization behavior (GO:0071625)2.41105711
145gamma-aminobutyric acid transport (GO:0015812)2.40208075
146sensory perception of chemical stimulus (GO:0007606)2.38990664
147DNA deamination (GO:0045006)2.36768098
148transmission of nerve impulse (GO:0019226)2.36285249
149regulation of translation, ncRNA-mediated (GO:0045974)2.34828028
150negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.34828028
151negative regulation of translation, ncRNA-mediated (GO:0040033)2.34828028
152determination of left/right symmetry (GO:0007368)2.34629468
153determination of bilateral symmetry (GO:0009855)2.34122397
154inner ear receptor stereocilium organization (GO:0060122)2.33729329
155positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32044045
156embryonic epithelial tube formation (GO:0001838)2.31869600
157pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.31076334
158regulation of inclusion body assembly (GO:0090083)2.30990685
159regulation of rhodopsin mediated signaling pathway (GO:0022400)2.30602248
160membrane depolarization during action potential (GO:0086010)2.29415276
161neurotransmitter metabolic process (GO:0042133)2.29221189
162pyrimidine-containing compound transmembrane transport (GO:0072531)2.28987809
163axonemal dynein complex assembly (GO:0070286)10.4314504
164cilium or flagellum-dependent cell motility (GO:0001539)10.3834152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.24920333
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.05119871
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94700284
4GBX2_23144817_ChIP-Seq_PC3_Human3.08966424
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65780174
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.63081727
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44355147
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38826372
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.22736886
10IGF1R_20145208_ChIP-Seq_DFB_Human2.21806820
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20435684
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.19082323
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07261186
14RNF2_27304074_Chip-Seq_NSC_Mouse2.06830069
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98769021
16TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.88987199
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84768042
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84611736
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84349296
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82889466
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81088190
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81030468
23EWS_26573619_Chip-Seq_HEK293_Human1.80257022
24VDR_22108803_ChIP-Seq_LS180_Human1.78415905
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.76139257
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.74689520
27TAF15_26573619_Chip-Seq_HEK293_Human1.74388495
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72492860
29SMAD4_21799915_ChIP-Seq_A2780_Human1.70245622
30REST_21632747_ChIP-Seq_MESCs_Mouse1.66608255
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66500103
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65618294
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65200914
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64467990
35FUS_26573619_Chip-Seq_HEK293_Human1.64081832
36BCAT_22108803_ChIP-Seq_LS180_Human1.63251165
37SUZ12_18555785_Chip-Seq_ESCs_Mouse1.62852305
38P300_19829295_ChIP-Seq_ESCs_Human1.62145381
39TAL1_26923725_Chip-Seq_HPCs_Mouse1.60065250
40STAT3_18555785_Chip-Seq_ESCs_Mouse1.59432092
41E2F1_18555785_Chip-Seq_ESCs_Mouse1.59058859
42P53_22387025_ChIP-Seq_ESCs_Mouse1.58826635
43AR_21572438_ChIP-Seq_LNCaP_Human1.57777435
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57046602
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56375999
46CBP_20019798_ChIP-Seq_JUKART_Human1.56283325
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56283325
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.54038861
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.53890309
50EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.53412393
51P300_18555785_Chip-Seq_ESCs_Mouse1.53125816
52AR_25329375_ChIP-Seq_VCAP_Human1.52586692
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52252690
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51967624
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50718905
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48773988
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.46704385
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.45109384
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44434877
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44434877
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.42130916
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.41821671
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.41382782
64TCF4_22108803_ChIP-Seq_LS180_Human1.39835715
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.39296972
66NMYC_18555785_Chip-Seq_ESCs_Mouse1.38933251
67ESRRB_18555785_Chip-Seq_ESCs_Mouse1.38840905
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38698757
69EZH2_27304074_Chip-Seq_ESCs_Mouse1.38639707
70ER_23166858_ChIP-Seq_MCF-7_Human1.38517845
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.38337159
72GATA1_26923725_Chip-Seq_HPCs_Mouse1.37339739
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.36977669
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36971884
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.34628988
76KDM2B_26808549_Chip-Seq_REH_Human1.32986106
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32648299
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32434934
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.31481488
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.31286251
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31040474
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30943897
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30642746
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.28089260
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28089260
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.27942616
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27942548
88KAP1_22055183_ChIP-Seq_ESCs_Mouse1.26106655
89PU1_27457419_Chip-Seq_LIVER_Mouse1.25787522
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.25046214
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24994998
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24740321
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24635635
94NANOG_19829295_ChIP-Seq_ESCs_Human1.24570775
95SOX2_19829295_ChIP-Seq_ESCs_Human1.24570775
96JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23654047
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23560643
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.23190891
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22743445
100SMAD1_18555785_Chip-Seq_ESCs_Mouse1.22646220
101SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21519899
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.21196466
103IRF1_19129219_ChIP-ChIP_H3396_Human1.21172297
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20402705
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.20353234
106TP53_22573176_ChIP-Seq_HFKS_Human1.20212079
107STAT3_23295773_ChIP-Seq_U87_Human1.19984056
108RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16700883
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16604357
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16275604
111TP53_16413492_ChIP-PET_HCT116_Human1.15856745
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.15653440
113DROSHA_22980978_ChIP-Seq_HELA_Human1.15223968
114TCF4_23295773_ChIP-Seq_U87_Human1.14874628
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14680397
116EED_16625203_ChIP-ChIP_MESCs_Mouse1.14081147
117AHR_22903824_ChIP-Seq_MCF-7_Human1.13782669
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.13642536
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12827437
120ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12346235
121CDX2_22108803_ChIP-Seq_LS180_Human1.11404451
122JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09662237
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09043900
124PIAS1_25552417_ChIP-Seq_VCAP_Human1.08733467
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08655777
126NCOR_22424771_ChIP-Seq_293T_Human1.08364301
127AR_20517297_ChIP-Seq_VCAP_Human1.08235696
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08105422
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08051253
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07726207
131STAT1_17558387_ChIP-Seq_HELA_Human1.06112759
132SOX9_26525672_Chip-Seq_HEART_Mouse1.05694571
133HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04830313
134BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04734975
135SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04589794
136ZNF274_21170338_ChIP-Seq_K562_Hela1.04487748
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04348273
138RUNX2_22187159_ChIP-Seq_PCA_Human1.04244615
139ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03453577
140HOXB7_26014856_ChIP-Seq_BT474_Human1.03096670
141TBL1_22424771_ChIP-Seq_293T_Human1.02608434
142FLI1_21867929_ChIP-Seq_TH2_Mouse1.02444355
143EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02442567
144FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01443394
145SOX2_21211035_ChIP-Seq_LN229_Gbm1.00562809
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00150629
147ETV1_20927104_ChIP-Seq_GIST48_Human0.99355752

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.98795382
2MP0001984_abnormal_olfaction3.99240390
3MP0002653_abnormal_ependyma_morphology3.59766920
4MP0006292_abnormal_olfactory_placode3.24676579
5MP0003880_abnormal_central_pattern3.00807162
6MP0003195_calcinosis3.00635057
7MP0005646_abnormal_pituitary_gland2.97503631
8MP0003136_yellow_coat_color2.68222861
9MP0008877_abnormal_DNA_methylation2.66683391
10MP0008875_abnormal_xenobiotic_pharmacok2.59622584
11MP0004043_abnormal_pH_regulation2.53821803
12MP0009046_muscle_twitch2.52634883
13MP0003698_abnormal_male_reproductive2.48694433
14MP0001188_hyperpigmentation2.21663017
15MP0001929_abnormal_gametogenesis2.21613801
16MP0002638_abnormal_pupillary_reflex2.06279546
17MP0002102_abnormal_ear_morphology1.96592044
18MP0000015_abnormal_ear_pigmentation1.93476061
19MP0002160_abnormal_reproductive_system1.93126689
20MP0005499_abnormal_olfactory_system1.89554135
21MP0005394_taste/olfaction_phenotype1.89554135
22MP0008789_abnormal_olfactory_epithelium1.89053977
23MP0005645_abnormal_hypothalamus_physiol1.88193937
24MP0008872_abnormal_physiological_respon1.84660427
25MP0001968_abnormal_touch/_nociception1.84227133
26MP0009745_abnormal_behavioral_response1.82141831
27MP0006276_abnormal_autonomic_nervous1.81996802
28MP0002572_abnormal_emotion/affect_behav1.81566555
29MP0002210_abnormal_sex_determination1.81063732
30MP0003878_abnormal_ear_physiology1.79940253
31MP0005377_hearing/vestibular/ear_phenot1.79940253
32MP0000383_abnormal_hair_follicle1.77366244
33MP0000427_abnormal_hair_cycle1.71334031
34MP0003635_abnormal_synaptic_transmissio1.70316521
35MP0004133_heterotaxia1.66275998
36MP0002736_abnormal_nociception_after1.65854211
37MP0000569_abnormal_digit_pigmentation1.64420862
38MP0001486_abnormal_startle_reflex1.63622132
39MP0003787_abnormal_imprinting1.63168043
40MP0002557_abnormal_social/conspecific_i1.59496134
41MP0005551_abnormal_eye_electrophysiolog1.57914037
42MP0004859_abnormal_synaptic_plasticity1.57268473
43MP0002837_dystrophic_cardiac_calcinosis1.56438495
44MP0002272_abnormal_nervous_system1.55883600
45MP0001485_abnormal_pinna_reflex1.54289637
46MP0002063_abnormal_learning/memory/cond1.52371065
47MP0002734_abnormal_mechanical_nocicepti1.51474518
48MP0004270_analgesia1.50827396
49MP0000631_abnormal_neuroendocrine_gland1.50321262
50MP0000026_abnormal_inner_ear1.50284386
51MP0005389_reproductive_system_phenotype1.49689995
52MP0008057_abnormal_DNA_replication1.49475386
53MP0004885_abnormal_endolymph1.48814063
54MP0002064_seizures1.47507802
55MP0005409_darkened_coat_color1.44090243
56MP0001501_abnormal_sleep_pattern1.43851021
57MP0003011_delayed_dark_adaptation1.39626899
58MP0002161_abnormal_fertility/fecundity1.39249356
59MP0005623_abnormal_meninges_morphology1.37226677
60MP0010386_abnormal_urinary_bladder1.36757305
61MP0008058_abnormal_DNA_repair1.35306658
62MP0005423_abnormal_somatic_nervous1.34584400
63MP0001145_abnormal_male_reproductive1.31826231
64MP0000778_abnormal_nervous_system1.31507367
65MP0000653_abnormal_sex_gland1.31196878
66MP0002277_abnormal_respiratory_mucosa1.28412775
67MP0001905_abnormal_dopamine_level1.27813505
68MP0001963_abnormal_hearing_physiology1.27135045
69MP0004145_abnormal_muscle_electrophysio1.27121543
70MP0004147_increased_porphyrin_level1.26559820
71MP0002928_abnormal_bile_duct1.25815566
72MP0002733_abnormal_thermal_nociception1.24465754
73MP0005171_absent_coat_pigmentation1.20765796
74MP0002938_white_spotting1.20383260
75MP0001986_abnormal_taste_sensitivity1.17843362
76MP0000566_synostosis1.14766696
77MP0002067_abnormal_sensory_capabilities1.12778993
78MP0002234_abnormal_pharynx_morphology1.12517435
79MP0001529_abnormal_vocalization1.12431965
80MP0005085_abnormal_gallbladder_physiolo1.11675384
81MP0005379_endocrine/exocrine_gland_phen1.09483379
82MP0002752_abnormal_somatic_nervous1.07780459
83MP0008995_early_reproductive_senescence1.07608199
84MP0005167_abnormal_blood-brain_barrier1.07586278
85MP0002282_abnormal_trachea_morphology1.07397290
86MP0002184_abnormal_innervation1.05707718
87MP0001502_abnormal_circadian_rhythm1.04834579
88MP0001765_abnormal_ion_homeostasis1.04352181
89MP0009780_abnormal_chondrocyte_physiolo1.03972022
90MP0002876_abnormal_thyroid_physiology1.03886855
91MP0005195_abnormal_posterior_eye1.03789536
92MP0005253_abnormal_eye_physiology1.03601497
93MP0003879_abnormal_hair_cell1.03334707
94MP0004742_abnormal_vestibular_system1.01596165
95MP0002735_abnormal_chemical_nociception0.99261455
96MP0001324_abnormal_eye_pigmentation0.99093468
97MP0005174_abnormal_tail_pigmentation0.98479494
98MP0006072_abnormal_retinal_apoptosis0.96658489
99MP0002909_abnormal_adrenal_gland0.96245120
100MP0001919_abnormal_reproductive_system0.95741766
101MP0002132_abnormal_respiratory_system0.95155535
102MP0001440_abnormal_grooming_behavior0.94249432
103MP0002882_abnormal_neuron_morphology0.93045861
104MP0002138_abnormal_hepatobiliary_system0.93023292
105MP0004381_abnormal_hair_follicle0.92893391
106MP0003950_abnormal_plasma_membrane0.92773432
107MP0004924_abnormal_behavior0.92685751
108MP0005386_behavior/neurological_phenoty0.92685751
109MP0002152_abnormal_brain_morphology0.92491299
110MP0003718_maternal_effect0.92036432
111MP0003252_abnormal_bile_duct0.91359115
112MP0002249_abnormal_larynx_morphology0.91277436
113MP0000230_abnormal_systemic_arterial0.90650373
114MP0002229_neurodegeneration0.89696932
115MP0008004_abnormal_stomach_pH0.89496019
116MP0005636_abnormal_mineral_homeostasis0.89310822
117MP0003137_abnormal_impulse_conducting0.88824885
118MP0005084_abnormal_gallbladder_morpholo0.88437448
119MP0003890_abnormal_embryonic-extraembry0.86583080
120MP0001664_abnormal_digestion0.85081146
121MP0001970_abnormal_pain_threshold0.84534940
122MP0005083_abnormal_biliary_tract0.82958807
123MP0002095_abnormal_skin_pigmentation0.82950183
124MP0004215_abnormal_myocardial_fiber0.82898048
125MP0003938_abnormal_ear_development0.82797762
126MP0003121_genomic_imprinting0.82504063
127MP0004085_abnormal_heartbeat0.82273295
128MP0003122_maternal_imprinting0.82214702
129MP0010678_abnormal_skin_adnexa0.81752079
130MP0002168_other_aberrant_phenotype0.80172549
131MP0002693_abnormal_pancreas_physiology0.78495497
132MP0005395_other_phenotype0.78147504
133MP0004019_abnormal_vitamin_homeostasis0.78021237
134MP0000049_abnormal_middle_ear0.78009404
135MP0000955_abnormal_spinal_cord0.72723049
136MP0003646_muscle_fatigue0.71673954
137MP0005075_abnormal_melanosome_morpholog0.71673676
138MP0000372_irregular_coat_pigmentation0.70907175
139MP0001177_atelectasis0.69633659
140MP0003941_abnormal_skin_development0.69148760
141MP0004142_abnormal_muscle_tone0.68577189
142MP0002127_abnormal_cardiovascular_syste0.67819781

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.31966415
2Abnormal ciliary motility (HP:0012262)8.90859391
3Absent/shortened dynein arms (HP:0200106)8.04129946
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.04129946
5Abnormal respiratory motile cilium morphology (HP:0005938)7.65300957
6Abnormal respiratory epithelium morphology (HP:0012253)7.65300957
7Rhinitis (HP:0012384)7.36919035
8Chronic bronchitis (HP:0004469)5.20790189
9Medial flaring of the eyebrow (HP:0010747)4.52828433
10Gait imbalance (HP:0002141)4.21316043
11Congenital primary aphakia (HP:0007707)4.20302940
12Pancreatic fibrosis (HP:0100732)4.17756107
13True hermaphroditism (HP:0010459)4.13674517
14Bronchiectasis (HP:0002110)4.10399137
15Nephrogenic diabetes insipidus (HP:0009806)3.87942038
16Nephronophthisis (HP:0000090)3.74536567
17Abnormality of midbrain morphology (HP:0002418)3.59006768
18Molar tooth sign on MRI (HP:0002419)3.59006768
19Infertility (HP:0000789)3.35727422
20Poor coordination (HP:0002370)3.33832040
21Pancreatic cysts (HP:0001737)3.28533012
22Congenital stationary night blindness (HP:0007642)3.22093876
23Tubulointerstitial nephritis (HP:0001970)3.20154973
24Genital tract atresia (HP:0001827)3.13619212
25Vaginal atresia (HP:0000148)3.05559617
26Type II lissencephaly (HP:0007260)2.97183876
27Decreased circulating renin level (HP:0003351)2.96853613
28Abnormality of the renal medulla (HP:0100957)2.92650301
29Occipital encephalocele (HP:0002085)2.89129882
30Postaxial foot polydactyly (HP:0001830)2.84098034
31Cystic liver disease (HP:0006706)2.82681401
32Nasal polyposis (HP:0100582)2.81365027
33Aplasia/Hypoplasia of the lens (HP:0008063)2.77657353
34Hyperventilation (HP:0002883)2.70238648
35Attenuation of retinal blood vessels (HP:0007843)2.63984490
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.60620682
37Gaze-evoked nystagmus (HP:0000640)2.57314234
38Congenital hepatic fibrosis (HP:0002612)2.54960285
39Genetic anticipation (HP:0003743)2.53559831
40Median cleft lip (HP:0000161)2.51929174
41Furrowed tongue (HP:0000221)2.50768727
42Recurrent sinusitis (HP:0011108)2.49686264
43Supernumerary spleens (HP:0009799)2.45368629
44Abolished electroretinogram (ERG) (HP:0000550)2.42124553
45Cerebellar dysplasia (HP:0007033)2.41572370
46Bronchitis (HP:0012387)2.40084541
47Bile duct proliferation (HP:0001408)2.40082867
48Abnormal biliary tract physiology (HP:0012439)2.40082867
49Abnormal rod and cone electroretinograms (HP:0008323)2.39544072
50Postaxial hand polydactyly (HP:0001162)2.39076251
51Chronic sinusitis (HP:0011109)2.34486137
52Preaxial hand polydactyly (HP:0001177)2.32421093
53Anencephaly (HP:0002323)2.28145759
54Chronic hepatic failure (HP:0100626)2.27166127
55Sclerocornea (HP:0000647)2.22506506
56Bony spicule pigmentary retinopathy (HP:0007737)2.22259284
57Male pseudohermaphroditism (HP:0000037)2.21952173
58Polyuria (HP:0000103)2.13271207
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09575077
60Hyperkalemia (HP:0002153)2.04978702
61Hyperactive renin-angiotensin system (HP:0000841)2.04352468
62Recurrent otitis media (HP:0000403)2.04309105
63Facial cleft (HP:0002006)2.04302183
64Febrile seizures (HP:0002373)2.04132218
65Abnormal hair whorl (HP:0010721)2.02355747
66Absent speech (HP:0001344)2.01784071
67Bifid tongue (HP:0010297)2.00300098
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00034624
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.0108143
70Increased corneal curvature (HP:0100692)1.99244751
71Keratoconus (HP:0000563)1.99244751
72Abnormality of the nasal mucosa (HP:0000433)1.98318568
73Specific learning disability (HP:0001328)1.97969461
74Atelectasis (HP:0100750)1.97784593
75Large for gestational age (HP:0001520)1.94774116
76Male infertility (HP:0003251)1.94559860
77Focal motor seizures (HP:0011153)1.93702072
78Abnormality of renin-angiotensin system (HP:0000847)1.92376180
79Broad foot (HP:0001769)1.91389743
80Abnormality of macular pigmentation (HP:0008002)1.90990562
81Decreased central vision (HP:0007663)1.87274466
82Hypothermia (HP:0002045)1.86532619
83Aganglionic megacolon (HP:0002251)1.85858026
84Broad-based gait (HP:0002136)1.85663349
85Abnormality of dentin (HP:0010299)1.85078202
86Optic nerve hypoplasia (HP:0000609)1.79454780
87Pendular nystagmus (HP:0012043)1.77950102
88Aplasia/Hypoplasia of the spleen (HP:0010451)1.76810139
89Chromsome breakage (HP:0040012)1.76510200
90Chronic otitis media (HP:0000389)1.75289475
91Hyperaldosteronism (HP:0000859)1.75280751
92Renal cortical cysts (HP:0000803)1.74966922
93Astigmatism (HP:0000483)1.73577239
94Stage 5 chronic kidney disease (HP:0003774)1.72505021
95Abnormal urine output (HP:0012590)1.71372803
96Lissencephaly (HP:0001339)1.70243200
97Inability to walk (HP:0002540)1.70110082
98Amelogenesis imperfecta (HP:0000705)1.69447807
99Abnormality of molar morphology (HP:0011070)1.69421780
100Abnormality of molar (HP:0011077)1.69421780
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69216356
102Abnormality of alanine metabolism (HP:0010916)1.69216356
103Hyperalaninemia (HP:0003348)1.69216356
104Epileptic encephalopathy (HP:0200134)1.68218332
105Asplenia (HP:0001746)1.67105630
106Fibular hypoplasia (HP:0003038)1.65211097
107Tubulointerstitial abnormality (HP:0001969)1.65021883
108Protruding tongue (HP:0010808)1.64502850
109Tubular atrophy (HP:0000092)1.63380678
110Oculomotor apraxia (HP:0000657)1.62537229
111Congenital sensorineural hearing impairment (HP:0008527)1.62147027
112Abnormality of renal excretion (HP:0011036)1.61694502
113Hypodontia (HP:0000668)1.60908800
114Concave nail (HP:0001598)1.60584845
115Abnormality of permanent molar morphology (HP:0011071)1.60498796
116Abnormality of the dental root (HP:0006486)1.60498796
117Taurodontia (HP:0000679)1.60498796
118Severe visual impairment (HP:0001141)1.59672723
119Renal dysplasia (HP:0000110)1.59471571
120Intestinal atresia (HP:0011100)1.58083772
121Short foot (HP:0001773)1.57238075
122Left ventricular hypertrophy (HP:0001712)1.56763799
123Dental crowding (HP:0000678)1.56122144
124Clumsiness (HP:0002312)1.55812220
125Retinal dysplasia (HP:0007973)1.54815766
126Abnormal drinking behavior (HP:0030082)1.53753458
127Polydipsia (HP:0001959)1.53753458
128Retinitis pigmentosa (HP:0000510)1.53287687
129Abnormality of the dental pulp (HP:0006479)1.52821548
130Abnormality of the renal collecting system (HP:0004742)1.51966920
131Abnormality of the renal cortex (HP:0011035)1.48605060
132Narrow forehead (HP:0000341)1.47287012
133Decreased testicular size (HP:0008734)1.44846826
134Progressive cerebellar ataxia (HP:0002073)1.44515027
135Multicystic kidney dysplasia (HP:0000003)1.44451658
136Oligohydramnios (HP:0001562)1.43937737
137Duplicated collecting system (HP:0000081)1.43763103
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.43487590
139Asthma (HP:0002099)1.42645037
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.40829793
141Nephroblastoma (Wilms tumor) (HP:0002667)1.40466192
142Septo-optic dysplasia (HP:0100842)1.39470757
143Atonic seizures (HP:0010819)1.39361537
144Adrenal hypoplasia (HP:0000835)1.39172466

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.20324075
2CASK3.71807879
3MAPK153.38288296
4ARAF3.16162288
5PNCK3.10273329
6ACVR1B2.78683812
7PDK32.78342987
8PDK42.78342987
9MAP4K22.49956398
10PDK22.44825247
11NTRK32.32270293
12BRAF2.16088616
13BMPR22.11082846
14TNIK1.97118623
15STK161.95604351
16EPHA41.94073919
17TAOK31.86592434
18MAP2K71.79362292
19NEK61.78851572
20STK38L1.76894158
21TLK11.76759033
22PLK41.72768031
23PRPF4B1.69287536
24GRK11.67498650
25NUAK11.63920931
26GRK71.53397571
27VRK11.50339042
28ADRBK21.48895010
29AKT31.43051471
30PLK21.42457441
31IRAK31.37366530
32PLK31.37088425
33GRK51.35249129
34PIM21.33833201
35MAPK131.32721848
36MST41.27542500
37PRKD31.25814933
38RIPK11.25572220
39BMPR1B1.23139723
40WNK41.21220826
41MAP3K121.19420671
42IRAK11.17238328
43MAP3K41.14932480
44CDK31.14788475
45NTRK21.11663476
46SGK21.08293270
47ZAK1.06694371
48STK241.06691185
49PTK2B1.00519608
50MAPKAPK31.00198094
51STK380.96279805
52TGFBR10.95842224
53IRAK20.92995848
54OXSR10.92603290
55MAP2K60.92547222
56WNK30.92255872
57SRPK10.90547191
58IRAK40.89984034
59BRSK20.88026198
60PAK30.87343177
61MARK10.87186383
62PRKCG0.86093324
63PIK3CG0.84378362
64SGK4940.81096620
65SGK2230.81096620
66YES10.78689539
67CAMK2A0.78512929
68CHEK20.76339880
69MUSK0.75014088
70PRKCE0.74787695
71PRKAA20.72857296
72MKNK20.72165353
73MAP3K70.70400276
74NLK0.69829371
75TIE10.68862550
76BCR0.68209383
77INSRR0.67980047
78TNK20.67686788
79TRIM280.67234657
80TESK10.66994339
81MINK10.66086224
82NME10.64194220
83CCNB10.61392375
84MAP3K60.61115150
85TTK0.59553163
86RPS6KA50.59547512
87PRKG10.59382099
88MAPKAPK50.59118637
89STK390.58946343
90KIT0.57992849
91STK110.57969926
92CDK80.57169006
93TEC0.56763872
94WEE10.56108528
95PRKCQ0.55720997
96PRKCI0.55698803
97TRPM70.55561919
98MAP3K20.55465124
99CAMK10.55262391
100WNK10.54057193
101DYRK1A0.53477436
102PINK10.53224268
103ADRBK10.52669708
104PRKAA10.52328142
105RIPK40.52233097
106PLK10.52041248
107STK30.50935372
108EIF2AK20.50547938
109EPHA30.50472606
110FER0.48986300
111CDC42BPA0.48185818
112CAMK1D0.47050311
113ERBB20.46700837
114CAMK1G0.44814565
115PRKACA0.44182118
116CAMK2B0.43422430
117LATS10.39867395
118FGFR20.39371764
119RPS6KA20.38932021
120PIK3CA0.37954436
121CHUK0.36950531
122ATM0.36149988
123IKBKB0.35915581
124TAOK20.35879169
125PKN10.35155972
126CDK50.34987117
127AURKA0.34754904
128PRKCZ0.34703213
129OBSCN0.34665765
130CAMK2G0.33864510
131MKNK10.33860523
132PRKCA0.33179561
133TXK0.31534535
134CSNK1G20.31419619
135CDK120.31111896
136CAMKK20.30807059
137CSNK1D0.30128705
138SGK30.30018971
139ERBB30.29728014
140MAPK100.29712313
141MELK0.29412534
142NEK20.29265018
143DAPK20.29082734
144PHKG10.28816591
145PHKG20.28816591
146RAF10.28577852
147MAP2K40.28200996
148DYRK20.26663149

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.61034309
2Olfactory transduction_Homo sapiens_hsa047403.25480352
3Phototransduction_Homo sapiens_hsa047442.71844784
4Butanoate metabolism_Homo sapiens_hsa006502.64582038
5Collecting duct acid secretion_Homo sapiens_hsa049662.62778743
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.60524195
7Nitrogen metabolism_Homo sapiens_hsa009102.46448777
8Fanconi anemia pathway_Homo sapiens_hsa034602.37400495
9Basal transcription factors_Homo sapiens_hsa030222.37346657
10Taste transduction_Homo sapiens_hsa047422.35335228
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33840198
12Amphetamine addiction_Homo sapiens_hsa050312.29754626
13Huntingtons disease_Homo sapiens_hsa050162.27618630
14Synaptic vesicle cycle_Homo sapiens_hsa047212.25155404
15Morphine addiction_Homo sapiens_hsa050322.24827964
16Circadian entrainment_Homo sapiens_hsa047132.22336354
17Tryptophan metabolism_Homo sapiens_hsa003802.20814108
18Glutamatergic synapse_Homo sapiens_hsa047242.20442764
19Insulin secretion_Homo sapiens_hsa049112.16553669
20Serotonergic synapse_Homo sapiens_hsa047262.01111518
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99336751
22ABC transporters_Homo sapiens_hsa020101.94871537
23Chemical carcinogenesis_Homo sapiens_hsa052041.91477130
24GABAergic synapse_Homo sapiens_hsa047271.90476843
25Histidine metabolism_Homo sapiens_hsa003401.69032949
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.68020805
27Dopaminergic synapse_Homo sapiens_hsa047281.65751345
28Oxidative phosphorylation_Homo sapiens_hsa001901.64643055
29beta-Alanine metabolism_Homo sapiens_hsa004101.53002967
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51212536
31Vitamin B6 metabolism_Homo sapiens_hsa007501.50900963
32Retinol metabolism_Homo sapiens_hsa008301.50755382
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.49114251
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.47552930
35Calcium signaling pathway_Homo sapiens_hsa040201.46147362
36Selenocompound metabolism_Homo sapiens_hsa004501.44392773
37Caffeine metabolism_Homo sapiens_hsa002321.41981064
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37690786
39Long-term potentiation_Homo sapiens_hsa047201.37681659
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37101333
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36755991
42Renin secretion_Homo sapiens_hsa049241.35637154
43Purine metabolism_Homo sapiens_hsa002301.34532017
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31993079
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29860833
46Peroxisome_Homo sapiens_hsa041461.27681668
47Arachidonic acid metabolism_Homo sapiens_hsa005901.27133695
48Cocaine addiction_Homo sapiens_hsa050301.23491422
49Homologous recombination_Homo sapiens_hsa034401.21716662
50Linoleic acid metabolism_Homo sapiens_hsa005911.18701259
51Alzheimers disease_Homo sapiens_hsa050101.16546724
52Non-homologous end-joining_Homo sapiens_hsa034501.16523996
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15234128
54Salivary secretion_Homo sapiens_hsa049701.13477047
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12825503
56Cholinergic synapse_Homo sapiens_hsa047251.12602778
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11321052
58Propanoate metabolism_Homo sapiens_hsa006401.10851501
59RNA polymerase_Homo sapiens_hsa030201.03390698
60Cardiac muscle contraction_Homo sapiens_hsa042601.02593743
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99254764
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99093283
63Pyruvate metabolism_Homo sapiens_hsa006200.98994932
64Circadian rhythm_Homo sapiens_hsa047100.97740467
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95638800
66Parkinsons disease_Homo sapiens_hsa050120.95437559
67Intestinal immune network for IgA production_Homo sapiens_hsa046720.95394059
68Ether lipid metabolism_Homo sapiens_hsa005650.94519182
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94019867
70Glycerolipid metabolism_Homo sapiens_hsa005610.91745172
71Ovarian steroidogenesis_Homo sapiens_hsa049130.91671058
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90140435
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88528076
74Oocyte meiosis_Homo sapiens_hsa041140.86038197
75Sphingolipid metabolism_Homo sapiens_hsa006000.84994593
76cAMP signaling pathway_Homo sapiens_hsa040240.84833282
77Fatty acid degradation_Homo sapiens_hsa000710.84699558
78RNA degradation_Homo sapiens_hsa030180.84411325
79Hedgehog signaling pathway_Homo sapiens_hsa043400.80881248
80Rheumatoid arthritis_Homo sapiens_hsa053230.80856712
81Gastric acid secretion_Homo sapiens_hsa049710.80631485
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79490877
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.78181060
84Long-term depression_Homo sapiens_hsa047300.77416740
85Pyrimidine metabolism_Homo sapiens_hsa002400.76926704
86One carbon pool by folate_Homo sapiens_hsa006700.75886303
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75726766
88Regulation of autophagy_Homo sapiens_hsa041400.75066828
89Tyrosine metabolism_Homo sapiens_hsa003500.74310762
90Glucagon signaling pathway_Homo sapiens_hsa049220.73747958
91Vibrio cholerae infection_Homo sapiens_hsa051100.70082245
92Dorso-ventral axis formation_Homo sapiens_hsa043200.69216222
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67324187
94Mineral absorption_Homo sapiens_hsa049780.66217422
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66154039
96Basal cell carcinoma_Homo sapiens_hsa052170.65812042
97Nucleotide excision repair_Homo sapiens_hsa034200.64816576
98Wnt signaling pathway_Homo sapiens_hsa043100.63741415
99Alcoholism_Homo sapiens_hsa050340.62912522
100Melanogenesis_Homo sapiens_hsa049160.61044715
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59867977
102Inositol phosphate metabolism_Homo sapiens_hsa005620.59535529
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58397499
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57575416
105Estrogen signaling pathway_Homo sapiens_hsa049150.57339800
106Protein export_Homo sapiens_hsa030600.57328930
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56206227
108Oxytocin signaling pathway_Homo sapiens_hsa049210.55532346
109Ras signaling pathway_Homo sapiens_hsa040140.55150024
110Phenylalanine metabolism_Homo sapiens_hsa003600.53914659
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53909916
112mRNA surveillance pathway_Homo sapiens_hsa030150.53483417
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.52205004
114Fatty acid biosynthesis_Homo sapiens_hsa000610.50671050
115Fat digestion and absorption_Homo sapiens_hsa049750.50375245
116GnRH signaling pathway_Homo sapiens_hsa049120.49417955
117Vitamin digestion and absorption_Homo sapiens_hsa049770.49175240
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47930954
119Glutathione metabolism_Homo sapiens_hsa004800.42716944
120Type I diabetes mellitus_Homo sapiens_hsa049400.41834871
121Pancreatic secretion_Homo sapiens_hsa049720.41074464
122Maturity onset diabetes of the young_Homo sapiens_hsa049500.38173748
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38029261
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37449985
125African trypanosomiasis_Homo sapiens_hsa051430.37147919
126Fatty acid metabolism_Homo sapiens_hsa012120.36823159
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35260625
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35140026
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35131588
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34263710
131Bile secretion_Homo sapiens_hsa049760.33070443
132Systemic lupus erythematosus_Homo sapiens_hsa053220.33010594
133Axon guidance_Homo sapiens_hsa043600.32964341
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32867769
135Thyroid hormone synthesis_Homo sapiens_hsa049180.31568105
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31504238
137Sulfur relay system_Homo sapiens_hsa041220.31354293
138Metabolic pathways_Homo sapiens_hsa011000.31082342
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.24650427
140Base excision repair_Homo sapiens_hsa034100.23677708
141MAPK signaling pathway_Homo sapiens_hsa040100.21654673

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